CN110680870A - Pain-relieving itching-relieving swelling-diminishing detoxifying liquid and preparation method thereof - Google Patents
Pain-relieving itching-relieving swelling-diminishing detoxifying liquid and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/648—Myriapods, e.g. centipedes or millipedes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/04—Antipruritics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention relates to the field of traditional Chinese medicines, in particular to an analgesic, antipruritic, detumescence and detoxification liquid and a preparation method thereof, wherein the analgesic, antipruritic, detumescence and detoxification liquid comprises the following raw materials in parts by weight: centipede: 3-10 parts of rhizoma paridis, 10-70 parts of rhizoma paridis, 5-50 parts of radix angelicae, 3-7 parts of menthol and 650 parts of alcohol 350-. The invention selectively matches medicinal materials with mild, cold and warm properties, has easily obtained raw materials and low price, and uses alcohol as an extraction solvent to obtain the pain-relieving, itching-relieving, swelling-eliminating and detoxifying liquid. Meanwhile, clinical application data show that the liquid for relieving pain, relieving itching, eliminating swelling and detoxifying is suitable for a wide range of people, can effectively relieve pain, relieve itching, diminish inflammation, sterilize, remove blood stasis and dissipate toxin, has practical curative effects on various poisonous insect bites such as poisonous snake bite, scorpion bite, hidden winged insect bite, caterpillar sting, ocean pepper bite, mosquito and fly bite, poisonous bee sting and the like, and can quickly achieve the curative effects of relieving itching, relieving pain and quickly eliminating swelling.
Description
Technical Field
The invention relates to the field of traditional Chinese medicines, in particular to an analgesic, antipruritic, detumescence and detoxification liquid and a preparation method thereof.
Background
Mosquitoes stab the skin through the mouth organ of the mosquitoes, saliva or venom injected into the skin generates allergic reaction after entering the skin of a human body to cause inflammation, and symptoms such as rash, pruritus and the like appear, if treatment is not carried out in time, local inflammation diffusion can be caused, and serious people can infect various diseases. For a long time, people cannot find special medicines for effectively treating the diseases, only ordinary liniments such as iodine tincture, cooling oil, floral water and the like can be used for smearing the bitten parts, although the ordinary liniments can relieve local pain, the effects are not ideal, particularly, the aims of quickly relieving itching, relieving pain and diminishing swelling are difficult to achieve, and the special medicines hardly play roles in biting of some poisonous insects which are more serious than mosquitoes, such as venomous snake bite, scorpion sting, winged insect bite, caterpillar sting, peppery seed sting and the like.
Disclosure of Invention
The invention aims to solve the technical problem of providing the analgesic, antipruritic, detumescence and detoxification liquid which has special effect on the bite of poisonous insects.
The technical scheme for solving the technical problems is as follows: the pain-relieving itching-relieving swelling-diminishing detoxifying liquid comprises the following raw materials in parts by weight: 3-10 parts of centipede, 10-70 parts of rhizoma paridis, 5-50 parts of angelica dahurica, 3-7 parts of menthol and 650 parts of alcohol 350-.
Further, the feed additive comprises the following raw materials in parts by weight: 5-8 parts of centipede, 20-60 parts of rhizoma paridis, 10-40 parts of radix angelicae, 4-6 parts of menthol and 550 parts of alcohol 450-.
Furthermore, the centipede is preferably the golden-head centipede.
Compared with common centipedes, the centipede has more excellent pharmacological action, and particularly when the centipede is mixed with the paris polyphylla, the angelica dahurica and the menthol crystal for use, the centipede has the best curative effects of toxin-vanquishing and cancer resistance, wind-extinguishing and spasmolysis, inflammation diminishing and sore treatment.
Further, the concentration of the alcohol is 65-85%.
A preparation method of detumescence antidote liquid comprises the following steps: soaking Scolopendra, rhizoma paridis and radix Angelicae Dahuricae in ethanol, extracting, filtering to remove residue, and adding Mentholum.
Further, the soaking and extracting conditions are that the sealed leaching is carried out for 10-20 days at normal temperature, and the stirring is carried out once every 1-3 days during the soaking period.
Further, the soaking extraction condition is reflux extraction at 70-90 ℃ for 3-5h, and cooling to room temperature after extraction is completed.
Pharmacological analysis of the analgesic, antipruritic, detumescence and detoxification liquid:
centipede: salty, pungent, warm and toxic, enter liver, spleen and lung meridians.
Rhizoma paridis: slightly cold in nature, bitter in taste and slightly toxic, entering liver meridian.
Radix angelicae: warm in nature, pungent and slightly sweet in flavor, with little toxicity, entering lung, spleen and stomach meridians.
Menthol: has antiviral, analgesic, antipruritic, anti-irritant, antitussive, and antibacterial effects
The invention relates to an analgesic, antipruritic, detumescence and detoxification liquid prepared by carefully selecting a medicine formula under the guidance of traditional Chinese medicine physiotherapy and clinical experience. Wherein, centipede: the main chemical components of the centipede are two toxic components similar to bee venom, namely histamine-like substances and hemolytic protein, and the modern traditional Chinese medicine pharmacological research proves that the centipede has the pharmacological effects of toxin-vanquishing and cancer resistance, wind-extinguishing and spasmolysis, inflammation diminishing and sore treatment; rhizoma paridis: has effects of clearing away heat and toxic materials, relieving swelling and pain, cooling liver, and arresting convulsion; radix angelicae: has effects in promoting pus discharge, promoting granulation, promoting blood circulation, and relieving pain; the Mentholum has effects of relieving inflammation, relieving pain, relieving itching, promoting blood circulation, and relieving edema. The medicinal components of the invention are compatible by differentiation of symptoms and signs, supplement each other in action, and jointly achieve the effects of detumescence, pain relief, blood circulation promotion, pus discharge, sterilization and disinfection.
Compared with the prior art, the invention has the beneficial effects that:
the invention selectively matches medicinal materials with mild, cold and warm properties, has easily obtained raw materials and low price, and uses alcohol as an extraction solvent to obtain the pain-relieving, itching-relieving, swelling-eliminating and detoxifying liquid. Meanwhile, clinical application data show that the liquid for relieving pain, relieving itching, diminishing swelling and detoxifying is suitable for a wide range of people, can effectively relieve pain, relieve itching, diminish inflammation, sterilize, remove blood stasis and dissipate toxin, has practical curative effects on various poisonous insect bites such as poisonous snake bites, scorpion bites, hidden winged insect bites, caterpillar bites, peppery seed bites and the like, and can quickly achieve the curative effects of relieving itching, relieving pain and quickly diminishing swelling.
Detailed Description
It should be noted that the following detailed description is exemplary and is intended to provide further explanation of the disclosure. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.
It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments according to the present application. As used herein, the singular forms also include the plural forms unless the context clearly dictates otherwise, and further, it is understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of the stated features, steps, operations, devices, components, and/or combinations thereof.
Hereinafter, embodiments of the present invention will be described in detail. The following examples are only for illustrating the technical solutions of the present invention more clearly, and therefore are only examples, and the protection scope of the present invention is not limited thereby.
The parts of the examples which are not specified in specific conditions were carried out according to conventional conditions or conditions recommended by the manufacturer, and the reagents or equipment used therefor which are not specified by the manufacturer are conventional products which are commercially available, and 1 part in the examples means 1 g.
Example 1
Soaking 3 parts of centipede, 10 parts of rhizoma paridis and 5 parts of angelica dahurica in 350mL of 85% alcohol for 10 days at normal temperature in a sealed manner, stirring the soaking solution once every 1 day, filtering out filter residues after the soaking is finished, and then adding 3 parts of menthol into the filtrate to obtain the pain-relieving, itching-relieving, swelling-diminishing and detoxifying solution.
Example 2
Soaking 10 parts of centipede, 70 parts of rhizoma paridis and 50 parts of angelica dahurica in 650mL of 85% alcohol under the condition of sealing and leaching for 20 days at the temperature of 30 ℃, stirring the soaking solution once every 3 days, filtering out filter residues after leaching, and then adding 7 parts of menthol into the filtrate to obtain the pain-relieving, itching-relieving, swelling-diminishing and detoxifying solution.
Example 3
Soaking 8 parts of centipede, 40 parts of rhizoma paridis and 30 parts of angelica dahurica in 500mL of 75% alcohol, hermetically leaching for 5 hours at 80 ℃, cooling to room temperature after leaching is finished, filtering filter residues, and then adding 5 parts of menthol into filtrate to obtain the pain-relieving, itching-relieving, swelling-reducing and detoxifying liquid.
Example 4
Soaking 5 parts of centipede, 20 parts of rhizoma paridis and 10 parts of radix angelicae in 450mL of 75% alcohol, hermetically leaching for 3 hours at 90 ℃, cooling to room temperature after leaching is finished, filtering filter residues, and then adding 4 parts of menthol into filtrate to obtain the pain-relieving, itching-relieving, swelling-reducing and detoxifying liquid.
Example 5
Soaking 8 parts of centipede, 60 parts of rhizoma paridis and 40 parts of angelica dahurica in 550mL of 75% alcohol, hermetically leaching for 4 hours at 70 ℃, cooling to room temperature after leaching is finished, filtering filter residues, and then adding 6 parts of menthol into filtrate to obtain the pain-relieving, itching-relieving, swelling-reducing and detoxifying liquid.
Comparative example
Soaking 8 parts of centipede and 30 parts of angelica dahurica in 400mL of 75% alcohol, hermetically leaching for 4 hours at 80 ℃, cooling to room temperature after leaching is finished, filtering out filter residues, and then adding 5 parts of menthol into the filtrate to obtain the pain-relieving, itching-relieving, swelling-diminishing and detoxifying liquid.
The treatment effects of example 3, the control example and the Liushen toilet water on 20 patients suffering from mosquito bites, caterpillar stabs and cryptopteris bites are as follows. Wherein, the inunction method is used for patients suffering from mosquito bites and hair bite; a method for treating cryptopterus insect bite by soaking medicinal liquid with cotton bud or gauze and applying to wound is provided. In addition, the effective criteria for the therapeutic effect are: the effects of relieving itching and pain can be achieved after the medicine is used, and the swelling can be basically and completely reduced after the medicine is used for 2 to 4 times; the criteria for determining the ineffectiveness of the therapeutic effect are: the itching and pain are not obviously reduced after the medicine is used, and the swelling and pain feeling still exists after the medicine is used for 5 times.
Table 1 comparison of the therapeutic effects of example 3 and the control
As can be seen from table 1, the Liushen toilet water of example 3 has an excellent treatment effect compared with the Liushen toilet water of the comparative example, wherein the effective rate of the treatment of mosquito bites of example 3 is 100%, and the effective rates of the treatment of both the carpenterworm stab and the cryptopteris bites can reach 95%; the effective rate of the control example for treating mosquito bites is 95 percent, the effective rate of the control example for treating the caterpillar stabs is only 35 percent, and the effective rate of the control example for treating the hidden wing insect bites is 25 percent; the effective rate of Liushen toilet water for treating mosquito bites is only 75%, the effective rate for treating caterpillar stabs is only 15%, and the effective rate for treating hidden-wing insect bites is 0%. Therefore, the effective rate of the liquid for treating mosquito bites, caterpillar stabs and winged insect bites in the embodiment 3 is far higher than that of the control example and Liushen toilet water, so that the itching-relieving, pain-relieving, swelling-reducing and detoxifying liquid has excellent curative effects of relieving pain and stopping itching and rapidly reducing swelling.
Typical cases are:
case 1: wangzhi, male, 60 years old and ankle of which are bitten by venomous snake, the itching-relieving, pain-relieving, swelling-diminishing and detoxifying liquid prepared in example 1 is used, after 1 time of external application, itching and pain are obviously eliminated, after 4 times of external application, swelling is basically and completely reduced, and the wound starts to heal.
Case 2: when the itching-relieving, pain-relieving, swelling-eliminating and detoxifying liquid prepared in example 2 is used for treating the stabbing injury of the young legs of a male in the age of 62 years, the itching and pain feeling is obviously eliminated after the first inunction, and the swelling and pain feeling is basically and completely eliminated after the second inunction for 2 times.
Case 3: zhangzhi, male, 57 years old, right foot stinged by scorpion, using the itching-relieving, pain-relieving, swelling-subsiding and detoxifying liquid prepared in example 4, the swelling and pain sensation was obviously eliminated after the first external application, and the swelling and pain sensation was completely eliminated after the external application for 2 times.
Case 4: zhangzhi, female, 60 years old, arm stabbed by caterpillars, using the itching-relieving, pain-relieving, swelling-subsiding and detoxifying liquid prepared in example 5, the swelling and pain sensation was obviously eliminated after inunction.
Case 5: after 1 time of external application, itching and pain feeling are obviously eliminated, and after 3 times of external application, swelling is basically completely relieved.
Case 6: if plum, male and 13 years old, and arms are stabbed by caterpillars, the itching-relieving, pain-relieving, swelling-reducing and detoxifying liquid prepared in example 4 is used, and the swelling and pain feeling is obviously eliminated after inunction.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (7)
1. The pain-relieving itching-relieving swelling-diminishing detoxifying liquid is characterized by comprising the following raw materials in parts by weight: 3-10 parts of centipede, 10-70 parts of rhizoma paridis, 5-50 parts of angelica dahurica, 3-7 parts of menthol and 650 parts of alcohol 350-.
2. The detumescence antidote liquid according to claim 1, characterized by comprising the following raw materials in parts by weight: 5-8 parts of centipede, 20-60 parts of rhizoma paridis, 10-40 parts of radix angelicae, 4-6 parts of menthol and 550 parts of alcohol 450-.
3. The detumescence antidote liquid according to claim 2, wherein the centipedes are preferably centipedes.
4. The detumescent antidote according to any one of claims 1-3, wherein the alcohol is present in a concentration of 65-85%.
5. The method for preparing the detumescence antidote according to any one of claims 1 to 4, comprising the steps of: soaking Scolopendra, rhizoma paridis and radix Angelicae Dahuricae in ethanol, extracting, filtering to remove residue, and adding Mentholum.
6. The method for preparing the detumescence antidote according to claim 5, wherein the soaking extraction is performed under the condition of normal temperature sealing extraction for 10-20 days, and the soaking period is performed with stirring once every 1-3 days.
7. The method for preparing the detumescence antidote according to claim 5, wherein the soaking extraction is performed under reflux extraction at 70-90 ℃ for 3-5h, and the solution is cooled to room temperature after the extraction is completed.
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| CN201910973490.6A CN110680870A (en) | 2019-10-14 | 2019-10-14 | Pain-relieving itching-relieving swelling-diminishing detoxifying liquid and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112472757A (en) * | 2020-12-21 | 2021-03-12 | 韩兵 | Bee venom spray disinfectant and preparation method thereof |
| CN113398162A (en) * | 2021-06-13 | 2021-09-17 | 深圳市金达地科技有限公司 | Multipurpose spraying agent |
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2019
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112472757A (en) * | 2020-12-21 | 2021-03-12 | 韩兵 | Bee venom spray disinfectant and preparation method thereof |
| CN113398162A (en) * | 2021-06-13 | 2021-09-17 | 深圳市金达地科技有限公司 | Multipurpose spraying agent |
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