CN105597036A - Traditional Chinese medicine composition for treating chronic rhinitis, preparation and preparation method of preparation - Google Patents
Traditional Chinese medicine composition for treating chronic rhinitis, preparation and preparation method of preparation Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating chronic rhinitis, a preparation and a preparation method of the preparation. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 7-12 parts of flos magnolia, 6-11 parts of curcuma zedoary, 5-8 parts of radix angelicae and 5-8 parts of elsholtzia cypriani. Essential oil is extracted from the traditional Chinese medicine composition; pharmaceutically acceptable auxiliary materials or auxiliary ingredients are added to prepare the pharmaceutically common external preparation. The traditional Chinese medicine composition disclosed by the invention has the efficacies of being fragrant, opening orifices, promoting qi circulation, dredging collaterals, removing blood stasis and dispersing phlegm, is significant in treatment when applied to treatment and prevention of chronic rhinitis, especially prethrombotic state of the chronic rhinitis. Compared with western medicine treatment, damage to the physiological mechanism of a nasal cavity can be avoided; the limitation of a single western medicine target is overcome; and compared with the traditional Chinese medicine, the prescription is simple, good in curative effect on chronic rhinitis, and high in recovery rate.
Description
Technical field
The invention belongs to drug world, be specifically related to a kind of Chinese medicine composition and formulation preparation method thereof for the treatment of rhinitis chronic.
Background technology
Rhinitis chronic is ear-nose-throat department common disease and frequently-occurring disease, comprises chronic simple rhinitis and chronic hypertrophic rhinitis, many because ofAcute rhinitis is repeatedly shown effect and is not obtained thorough healing and due to delaying, and can be one-sided morbidity or bilateral morbidity. This disease is often sent out repeatedlyDo, protracted course of disease, shows effect more than continuing the several months or repeatedly. Pathological manifestations is mainly the chronic expansion of blood vessel in mucous membrane, permeabilityChange, especially the most obvious with the variation of concha cavernous body, submucosa has slurries storage to stay, and roundlet around occurs for blood vessel and body of glandCellular infiltration, therefore turbinate mucosa swelling, epithelial cell thickening, attenuation or part disappear, the intermittent phase also can not recover normally,All the time companion's dysfunction in various degree, normal without clear and definite pathogenic microorganism infection.
This disease of western medical treatment adopts the medicine treatments such as glucocorticoid, decongestant, mucus eccritic, and operative treatment,Laser therapy, electricity are pressed the methods such as method, micro-wave therapeutic, liquid nitrogen cryotherapy, RF therapy, and the curative effect past has significantly to be carriedHeight, but mainly to destroy physiological structure as cost, and late result is satisfied not, conventionally can only of short duration onset, unsatisfactory curative effectOr lasting curative effect is not good enough, and the postoperative possibility that has generation atrophic rhinitis.
In traditional chinese medicine, rhinitis belongs to nasosinusitis category. " nasosinusitis " word derives from "Nei Jing" the earliest, before more than 2,000 year" Plain Questions lose consciousness opinion " in record: nasosinusitis person, rhinorrhea with turbid discharge also, passes as maggot Pallas pit viper eyes, therefore lose consciousness also. The traditional Chinese medical scienceMedicine, in the disease for the treatment of rhinitis and rhinitis chronic, has obvious advantage, controls by dialectical opinion, has formed multiple treatment sideMethod: " doctor's mirror at all times " subtracts with pungent temperature sensible with sensible Tonga, expelling wind and cold pathogens. " warm disease bar is distinguished " adds and subtracts with pungent cool with Yinqiao SanSensible, expelling wind and cold pathogens. Golden Mirror of Medicine is drunk with powder for clearing lung-heat heresy with flower bud of lily magnolia clearing lung-heat, and promoting the circulation of qi is sensible. " soup medical university is complete " uses warm lungFluid stopping pellet adds taste with help lung spleen, is applicable to Lung Qi deficiency person.
Acute rhinitis is shown effect repeatedly, and prolonged illness negative and positive of qi and blood is all damaged, the not smooth stasis of blood that forms of blood operation, therefore have " the many stasis of bloods of prolonged illness " itSay. " treatise on blood trouble " said: " all incurable diseases, always by being not good at the event of the Eradicates stasis of blood ". The diseased region of rhinitis chronic is at concha, nothingOpinion chill or wind-heat, breath or the stagnation of the circulation of vital energy are all because evil poison is stranded in concha, cause that concha is congested for a long time, with the passing of time causeBlood stasis, thus clinical summary think rhinitis chronic mostly be qi depression to blood stasis, gather due to.
From the above mentioned, clinical common rhinitis chronic is carried out to differential diagnosis in tcm analysis, this disease generally can be divided into rhinitis chronic syndrome of qi deficiencyType and rhinitis chronic syndrome of blood stasis type. Rhinitis chronic syndrome of qi deficiency belongs to chronic simple rhinitis more, shows as schneiderian membrance deep arteryBe chronic expansion with the cavernous sinusoids of vein, particularly concha nasalis inferior, permeability increases, and blood vessel and body of gland around have with lymphCell and thick liquid cell are main inflammatory cell infiltration, and mucous gland function is active, and secretion increases; Rhinitis chronic syndrome of blood stasis type is manyBelong to chronic hypertrophic rhinitis, Early manifestation is the expansion of schneiderian membrance lamina propria artery and vein, and vein and lymphatic vessel peripheral lymphoid are thinBorn of the same parents and plasmocyte infiltrating, vein and lymphatic vessel backflow obstacle, vein permeability increases, mucosa lamina propria oedema. Development in late periodFor even limitation or the diffusivity proliferation of fibrous tissue plumpness of periosteum and bone of mucous membrane, submucosa. Clinical in rhinitis chronic bloodStasis syndrome type is the most common, and rhinitis chronic syndrome of qi deficiency type also usually can change into syndrome of blood stasis type simultaneously.
Therefore, rhinitis chronic syndrome of blood stasis type is comparatively common, on to its treatment, except awakening consciousness treatment, also should regulate the flow of vital energy logicalNetwork, blood stasis-eliminating and stagnation-dissipating.
And find by the existing Chinese patent drug of retrieval, treat at present the Chinese medicine of rhinitis chronic mainly to control from the sensible opinion of dispelling wind, as grey pungentAerosol, fragrant chrysanthemum granules, fragrant chrysanthemum sheet etc.; Or control from heat-clearing, removing toxic substances, the sensible aspect of dampness removing opinion, as magnolia flower rhinitis-treating pill, twoPungent rhinitis particle, rhinitis tablet, BIYUANSHU KOUFUYE, bidouyan mixture, bidouyan koufuye, sharp rhinarium, rhinitis syrup, bidouyan mixture, bidouyan koufuye,DITONG BIYAN SHUI, TONGXIAO BIYAN PIAN, medicine for treating rhinitis ball, health and happiness rhinitis tablet, XINFANG BIYAN JIAONANG etc., but do not have the fragrance of employing logicalKey, regulating qi and dredging collateral, blood stasis-eliminating and stagnation-dissipating opinion are controlled the medicine of composition.
And by patent retrieval, find that Chinese patent 201010551582.4 discloses one and had sensible stagnation resolvation, softening and resolving hard massThe Chinese medicine preparation of effect, is made up of the root of Chinese wild ginger, Chinese honey locust, only contains the armaticity Chinese medicine root of Chinese wild ginger simply, and prescription derives from test prescription,On prescription theory, be partial to sensiblely, and exist in actual applications the excitant of Chinese honey locust large, root of Chinese wild ginger Poisoning composition aristolochic acidEasily cause the situation of bad reaction. Chinese patent 201510183447.1 disclose one have a surname clearing the nasal passage, clearing heat and detoxicating,The Chinese medicine preparation of the Sweeling-eliminating medicine powder stasis of blood, eliminating stasis and resolving masses effect, exists again prescription flavour of a drug larger, the oral medication lesions position that can not go directly.Chinese patent 201410394350.0 discloses a kind of preparation for the treatment of atrophic rhinitis, by dark plum, the dried rhizome of rehmannia, radix scrophulariae,Vitamin E composition, Integrative Chinese-Western, and do not adopt the rules for the treatment of of awakening consciousness, therefore, from patent, there is not the virtue of employingFragrant sensible, regulating qi and dredging collateral, blood stasis-eliminating and stagnation-dissipating opinion are controlled the medicine of composition.
And know grid database literature search by China, though find on clinical prescription to have the square medicine of controlling from stasis of blood opinion, exist and lackThe medicine of weary awakening consciousness, treatment theory is only based oneself upon from blood stasis opinion and is controlled, and most prescription flavour of a drug are numerous, prescription amount large, useMedicine is not smart, how oral specific aim is not strong,, lack the situation of awakening consciousness medicine, the direct employing Blood-Activating-and-Stasis-Removing very havingMedicine, as Fufang Danshen Pian, Taohong Siwu Tang prescription therapeutic, adopts oral mode to treat, and can not directly arrive agents area.
By above disease, pathological characteristic, Clinical Application Analysis to rhinitis chronic, at present the medicine of rhinitis chronic orAll there are some drawbacks many or less, therefore, be necessary to find a kind of medicine that can effectively treat rhinitis chronic, solve Western medicineTarget spot is single, operative treatment destroys again physiology of the nose structure, treatment by Chinese herbs is dialectical not comprehensively, not strong, the most medicine of specific aimOral administration reaches the problem of lesions position because of the special physiological structure difficulty of schneiderian membrance.
Summary of the invention
For the deficiency of existing treatment rhinitis chronic, the object of the invention is to solve prior art and have that flavour of a drug are numerous, prescription amountGreatly, strong, the difficult problem that reaches lesions position of active ingredient of not smart, the specific aim of medication, and provide, a kind of prescription is simple, medicationThe Chinese medicine composition of essence road, through lesions position, said composition is the flower bud of lily magnolia, curcuma zedoary, the root of Dahurain angelica, tomentosecalyx elsholtzia leaf four taste Chinese medicine compositions,Have the effect of awakening consciousness, regulating qi and dredging collateral, blood stasis-eliminating and stagnation-dissipating, treatment rhinitis chronic effect is remarkable, and has toxic and side effectFeature low, easy to operate, evident in efficacy.
Another object of the present invention is to provide a kind of preparation method of Chinese medicinal composition preparation for the treatment of rhinitis chronic, and the method isSumming up on clinical practice said composition fumigation treatment rhinitis chronic basis evident in efficacy each flavour of a drug in binding compositionsChemical composition, is prepared into nasal cavity gel preparation, and the lesions position that can go directly further embodies the characteristic advantage of traditional Chinese medicine.
The present invention adopts following technical scheme: a kind of Chinese medicine composition for the treatment of rhinitis chronic, this Chinese medicine composition is by weighing belowThe Chinese medicine composition of amount proportioning: 5～8 parts of 7～12 parts of the flower buds of lily magnolia, 6～11 parts of curcuma zedoarys, 5～8 parts of the roots of Dahurain angelica and tomentosecalyx elsholtzia leafs.
The formulation preparation method of this Chinese medicine composition, is characterized in that, comprises the steps:
1) flower bud of lily magnolia, curcuma zedoary, the root of Dahurain angelica and tomentosecalyx elsholtzia leaf are taken by formula, distillation or extracting process extract and obtain volatile oil;
2) by the above-mentioned volatile oil of collecting, add pharmaceutically acceptable auxiliary material or complementary composition, be prepared into nasal cavity and useAromatic waters, spray, gel or aerosol.
Further, described distillating method is: the flower bud of lily magnolia, curcuma zedoary, the root of Dahurain angelica and tomentosecalyx elsholtzia leaf are taken by formula, add medicinal material weight4～10 times of water gagings, soak 0～2 hour, adopt straight-through Steam Heating or distillation mode that directly heating decocts distill 4～7 hours, collect and obtain volatile oil.
Further, described extracting process is: the flower bud of lily magnolia, curcuma zedoary, the root of Dahurain angelica and tomentosecalyx elsholtzia leaf are taken and are ground into coarse granule by formula;Carbon dioxide supercritical extraction 2～6 hours, obtains the volatile oil of said preparation; Wherein extraction conditions is: extracting pressure 20～35MPa, 30～40 DEG C of extraction temperature, carbon dioxide flow: 300～600L/h.
By the above-mentioned volatile oil of collecting, add pharmaceutically acceptable auxiliary material or complementary composition, be prepared into conventional external applicationPreparation. Wherein, described external preparation comprises aromatic waters for nasal cavity, spray, aerosol or gel.
Further, the preparation method of described gel is: 1 part of volatile oil, add 0.5～4 part, surfactant, and antibacterial0.005～0.1 part of ground and mixed of agent is even; Add containing 0.1～1 part of zinc gluconate, 0.1～0.5 part, sodium chloride, glycerineThe aqueous solution of 0.2～2 part, stirs, and makes each composition emulsification, dissolves, is uniformly dispersed; Add again the gel after swelling treatment2～10 parts of matrix, and mend add water to configuration total amount, be uniformly mixed and form.
Wherein, the described gel-type vehicle after swelling treatment is that sodium carboxymethylcellulose or carbomer add 15～25 times of amountsThe gel-type vehicle of swelling treatment gained after water. Described bacteriostatic agent is methyl hydroxybenzoate or ethylparaben. Live in described surfaceProperty agent is Tween-80, Tween-60, rilanit special APEO or sodium sulfate of polyethenoxy ether of fatty alcohol.
Chinese medicine composition of the present invention is worked in coordination with by formula and is formed by the flower bud of lily magnolia, curcuma zedoary, the root of Dahurain angelica, tomentosecalyx elsholtzia leaf four taste Chinese medicines, and the flower bud of lily magnolia isMonarch, curcuma zedoary is minister, two medicine gas fragrance and clearing the nasal passage refetch again ministerial drug curcuma zedoary and enter the merit of blood system blood stasis-eliminating and stagnation-dissipating, eliminate the concha stasis of bloodTie and dredging collateral; Be aided with again the root of Dahurain angelica, tomentosecalyx elsholtzia leaf two medicines, strengthen the flower bud of lily magnolia and the sensible dissipating bind of curcuma zedoary, the merit of detumescence and apocenosis, four tastesMedicine share the merit of playing altogether awakening consciousness, regulating qi and dredging collateral, blood stasis-eliminating and stagnation-dissipating, the various discomforts that treatment relieve chronic rhinitis cause.In each medicine, the very strong pharmacologically active of contained armaticity volatile oil material tool, can effectively shrink nasal mucosa vessels, improves noseMucous membrane microcirculation, alleviates allergic reaction; Meanwhile, we except having awakening consciousness effect, also have multiple anti-inflammatory, antibacterial,Antiviral, antiallergy, antipyretic, analgesic activity, have good external application basis, and rhinitis chronic is had to good curative effect.Analyze from chemical composition, all containing the stronger volatile ingredient of higher pharmacologically active, except having very strong awakening consciousness effect,Also have regulating qi and dredging collateral, blood stasis-eliminating and stagnation-dissipating effect, pass through clinically fumigation treatment, treatment rhinitis chronic, especially rhinitis chronicSyndrome of blood stasis type is evident in efficacy.
The flower bud of lily magnolia, pungent, temperature, attaches to the lung and stomach meridians. For treatment rhinopathy key medicine, can expelling wind and clearing away cold, up in women's head-ornaments and kind clearing the nasal passage.In Compendium of Material Medica, record: " nasosinusitis, allergic rhinitis, chronic rhinitis, nose sore after nose sore and acne. The pungent temperature of the flower bud of lily magnolia, flat and enter lung,Can help in stomach clear sun up, so in can temperature, control the disease of women's head-ornaments order nose. " magnolia flower volatile oil content is higher, has contraction schneiderian membraneThe effect of blood vessel, can protect the absorption of schneiderian membrane, promotion mucous membrane secretion, reduces inflammation.
Curcuma zedoary, pungent, bitter, temperature, returns liver, the spleen channel, effect that tool promoting the circulation of qi is broken blood, removed obstruction in channels to relieve pain, its effect of well invigorating blood circulation,Can improve blood vessel microcirculation, eliminate concha swelling. Meanwhile, modern pharmacological research proves, Curcuma Aromatic Oil has anti-inflammatory townThe effect such as platelet aggregation-against, antibacterial, antiviral, anti-leukocythemia bitterly.
The root of Dahurain angelica, pungent, temperature, attaches to the lung and stomach meridians, and has expelling wind and clearing away cold, understand things pain-stopping, and the merit of detumescence and apocenosis, also for controlling rhinopathyKey medicine, records in Compendium of Material Medica: " control nasosinusitis, nosebleed epistaxis, pain in the supra-orbital bone. " record the root of Dahurain angelica and the flower bud of lily magnolia in recipes for Saving LivesDispel the wind and dredge table, a surname's clearing the nasal passage, wherein pungent Wen Xiang alters, expelling wind and promoting the restoration of consciousness, the kind yangming headache (forehead headache) of controlling again, root of Dahurain angelica treatmentThe main component of rhinitis is volatile oil component. Essential Oil of Radix Angelicae Dahuricae has the effect of analgesia, calmness; " collection of prescriptions with notes " " root of Dahurain angelica ...Up women's head-ornaments, logical strange diaphoresis, the loose wind of dehumidifying; The flower bud of lily magnolia leads to nine orifices ... "
Tomentosecalyx elsholtzia leaf, pungent, cool, return lung channel, there is heat-clearing, removing toxic substances, the merit of inducing sweat, for controlling nasosinusitis common medicine. Tomentosecalyx elsholtzia leaf volatilizationOil have significantly antibacterial, eliminate the phlegm, the effect such as antiallergy, inhibition aflatoxin, and have good relieving superficies by cooling,Clearing the nasal passage effect.
To sum up, compared to existing technology, the present invention has following beneficial effect:
1, Chinese medicine composition prescription of the present invention is simple, medication is simplified, with strong points, have awakening consciousness, regulating qi and dredging collateral,The effect of blood stasis-eliminating and stagnation-dissipating, treatment rhinitis chronic effect is remarkable, especially with strong points in treatment rhinitis chronic syndrome of blood stasis type, energyEffectively making up existing treatment prescription adopts simple opinion promoting blood circulation and removing blood stasis to control or adopts merely awakening consciousness opinion to control method treatment rhinitisDeficiency, has unique advantage.
2, Chinese medicine composition of the present invention flavour of a drug used are aromatics Chinese medicine, contain volatilization higher and the stronger pharmacologically active of toolOils composition, awakening consciousness action effect is good, and pharmacologically active report has multiple anti-inflammatory, antibacterial, antiviral, anti-mistake simultaneouslyQuick, antipyretic, analgesic activity, therefore, overcome the single drawback of Western medicine target spot, has good clinical practice basis.
3, this Chinese medicine composition is according to early stage clinical practice basis and each flavour of a drug chemical composition, in Chinese medicine preparation preparation technology,Adopt modern Chinese herbal medicine extraction process, only extract the strongest volatile oil component of pharmacologically active in each flavour of a drug, discard the dross and select the essential, and preparationBecome modern preparation, make Chinese medicine application modernization on the one hand, embodied again on the other hand the distinctive application advantage of traditional Chinese medicine.
4, according to the physiological structure feature of the pathogenic factors of rhinitis chronic and nose position, the clinical practice form of this Chinese medicine preparationFor external preparation carries out topical therapeutic, the lesions position that can go directly, than other methods for the treatment of, can not destroy physiological structure,More can embody the advantage of Chinese medicine rhinitis chronic.
5, the present invention is than other western medicine therapy (as antibiotic, hormone etc.), toxic and side effect is little, it is safer to use for a long time,Patient is easier to accept, and compliance is better.
6, this composition contains a large amount of volatile oil, while being generally prepared into liquid preparation, all needs first volatile oil to be carried out to parcel placeManage into after water-soluble and could use, and the present invention is by adopting mixed surfactant, macromolecular material etc. to make volatile oil evenBe dispersed in gel, the technology such as adjusting, moisturizing processing of oozing such as add, gel preparation and the mucous membrane etc. of preparation ooze, affineStrong, the homogeneous exquisiteness of property, stretchability and adherence are good.
7, this prescription is parts of generic medicinal plants, safe, and raw material is easy to get, with low cost.
Detailed description of the invention
For showing effect of the present invention, further illustrate the present invention below by specific embodiment. But, should be understood to,These embodiment are only used for the use specifically describing more in detail, and should not be construed as for limiting in any form thisInvention.
One, a kind of Chinese medicine composition volatile oil preparation method who treats rhinitis chronic:
Embodiment 1: volatile oil steam distillation preparation method
5 parts of 5 parts of tomentosecalyx elsholtzia leafs of 11 parts of roots of Dahurain angelica of 7 parts of curcuma zedoarys of the flower bud of lily magnolia
Get according to the above ratio the flower bud of lily magnolia, curcuma zedoary, the root of Dahurain angelica, tomentosecalyx elsholtzia leaf four taste Chinese medicines, 5.04kg medicinal material drops into 50L Multifunction hand altogetherGet in tank, add 5 times of water gagings, open multi-function extractor and add hot reflux 6 hours, and collect and volatilize with volatile oil collectorThe about 42ml of oil.
Embodiment 2: volatile oil steam distillation preparation method
8 parts of 8 parts of tomentosecalyx elsholtzia leafs of 6 parts of roots of Dahurain angelica of 12 parts of curcuma zedoarys of the flower bud of lily magnolia
Get according to the above ratio the flower bud of lily magnolia, curcuma zedoary, the root of Dahurain angelica, tomentosecalyx elsholtzia leaf four taste Chinese medicines, 5.1kg medicinal material drops into 50L Multifunction hand altogetherGet in tank, add 6 times of water gagings, soak 1 hour, open multi-function extractor and add hot reflux 5 hours, and receive with volatile oilStorage is collected the about 37ml of volatile oil.
Embodiment 3: volatile oil steam distillation preparation method
7 parts of 7 parts of tomentosecalyx elsholtzia leafs of 7 parts of roots of Dahurain angelica of 9 parts of curcuma zedoarys of the flower bud of lily magnolia
Get according to the above ratio the flower bud of lily magnolia, curcuma zedoary, the root of Dahurain angelica, tomentosecalyx elsholtzia leaf four taste Chinese medicines, 4.8kg medicinal material drops into 50L Multifunction hand altogetherGet in tank, add 9 times of water gagings, soak 1 hour, open multi-function extractor and add hot reflux 7 hours, and receive with volatile oilStorage is collected the about 40ml of volatile oil.
Embodiment 4: volatile oil supercritical extract preparation method
6 parts of 6 parts of tomentosecalyx elsholtzia leafs of 9 parts of roots of Dahurain angelica of 10 parts of curcuma zedoarys of the flower bud of lily magnolia
Get according to the above ratio the flower bud of lily magnolia, curcuma zedoary, the root of Dahurain angelica, tomentosecalyx elsholtzia leaf four taste Chinese medicines, 21.7kg pulverizing medicinal materials becomes coarse granule altogether,Through carbon dioxide supercritical extraction 4 hours, extracting pressure 30MPa, 35 DEG C of extraction temperature, carbon dioxide flow:400L/h; Obtain the about 235ml of volatile oil.
Two, a kind of gel preparation preparation method who treats rhinitis chronic:
Embodiment 5: a kind of gel preparation preparation method who treats rhinitis chronic:
(1) get above-described embodiment 4 gained volatile oil 40ml.
(2) get recipe quantity zinc gluconate 15g, sodium chloride 6g, glycerine 18ml, add 300ml distilled water, stirMix make molten.
(3) sodium carboxymethylcellulose is added in 300ml distilled water, swelling, heating if desired.
(4) according to prescription, methyl hydroxybenzoate 3g is added in volatile oil and dissolved completely, add rilanit special polyoxyVinethene 20ml, stirs and makes to mix, then add AES～Na20ml, mixes.
(5) step (2) aqueous solution is added in step (4), continues to stir 30 minutes, make each composition abundantEmulsification, dissolving, dispersion homogeneous.
(6) the sodium carboxymethylcellulose matrix after swelling and (5) liquid is always mixed, supplementing water is to cumulative volume 1000ml,Stir, make to mix being uniformly dispersed, to obtain final product.
Three, implementation result
1, due to we early stage clinical by fumigation treatment rhinitis chronic, determined curative effect, for proving its clinical efficacyCertainty, has made part statistics, and result is as follows:
Case 48 examples, the wherein male sex's 27 examples, female's surname 21 examples: the oldest 69 years old, minimum 7 years old, the course of disease was the longest12 years, the shortest half a year. All there is the typical clinical performance of rhinitis chronic in all patients, as there is for a long time or repeatedly noseThe uncomfortable reactions such as plug, nose endocrine increase, giddy, headache, adopt fumigation treatment, and stifling 30～50 minutes at every turn,Sooner or later each 1 time, by using the course for the treatment of after Chinese medicine composition of the present invention, recovery from illness 46 examples, most of transference cure (effectively)2 examples, cure rate 95.8%, efficient 100%.
Model case:
Case 1: week so-and-so, man, 40 years old. Readme is rhinitis chronic patient, continuous nasal obstruction, oral multi-treatment diseaseFeelings repeatedly. It is how yellow thick that clinical manifestation is mainly tears, baryo,dmia, tinnitus companioned with headache. Red tongue body is with petechia, arteries and veinsString is thin, is diagnosed as rhinitis chronic syndrome of blood stasis type. Use this traditional Chinese medicine composition water of embodiment 1 to decoct fumigation treatment, eachConsumption is: flower bud of lily magnolia 7g, curcuma zedoary 11g, root of Dahurain angelica 5g and tomentosecalyx elsholtzia leaf 5g, and stifling 30～50 minutes at every turn, each 1 time sooner or later,Treat 5 days afterwards headache obviously alleviate, nasal obstruction is alleviated, and continues to use after 2 weeks, nasal secretion obviously reduces, readmeSense of discomfort obviously alleviates, adheres to using after 2 courses for the treatment of (4 weeks being a course for the treatment of), and transference cure, patient is rear goodGood.
Case 2: Lee so-and-so, female, 51 years old. Within 5 years, cause flu is suffered from acute rhinitis, and with the passing of time treatment in time, do not delay,Be converted into rhinitis chronic, often occur that nose flows dense tears. Within nearly 1 year, because locating climacteric, mood is fidgety, causes aggravation,Except nose endocrine showed increased, also, with serious dizzy headache, tinnitus is not clever, red tongue body, and small and wiry pulse, belongs to chronicRhinitis syndrome of blood stasis type. Patient, when routine is taken alleviation menopause symptom medicine, uses in the formula of embodiment 4Drug composition decocting boils fumigation treatment, and each consumption flower bud of lily magnolia 10g, curcuma zedoary 9g, root of Dahurain angelica 6g and tomentosecalyx elsholtzia leaf 6g are at every turn smokedSteam 30～50 minutes, each 1 time sooner or later, to treat after 7 days, nasal cavity pussy discharge obviously reduces, and headache is alleviated, and suffers fromPerson's readme is fumigated also has the effect of good alleviation mood. Continue after stifling 1 course for the treatment of (4 weeks being a course for the treatment of),Have a stuffy nose unobstructed, no longer flow turbid tears, it is normal that schneiderian membrane recovers, recovery from illness. After 1 year, follow up a case by regular visits to, not recurrence.
Case 3: king so-and-so, female, 40 years old. From being set forth in the nearly 1 year normal alternately property nasal obstruction that occurs, sense of smell is poor, Shi QingshiHeavy, follow in the recent period and occur obviously headache. Diagnosis finds that schneiderian membrance is red red, dimly red tongue, stringy and hesitant pulse. Be defined as chronicRhinitis syndrome of blood stasis type. Use the formula traditional Chinese medicine composition water of embodiment 2 to decoct fumigation treatment, each consumption is: flower bud of lily magnolia 12g,Curcuma zedoary 6g, root of Dahurain angelica 8g and tomentosecalyx elsholtzia leaf 8g, stifling 30～50 minutes at every turn, each 1 time sooner or later, treat after 5 days, suffer fromPerson's disappearance of having a headache, nasal secretion obviously reduces, and adheres to using after 2 courses for the treatment of (4 weeks being a course for the treatment of) symptomDisappear, recovery from illness, favourable prognosis.
Case 4: shut out so-and-so, man, 16 years old. Within nearly 1 year, occur continuous nasal obstruction, tears are how yellow thick, more sticky, companion's languageNot smooth, dimly red tongue, stringy and hesitant pulse. Be diagnosed as rhinitis chronic syndrome of blood stasis type. Use the formula Chinese traditional medicine composition of embodiment 3Thing decocting boils fumigation treatment, and each consumption is flower bud of lily magnolia 9g, curcuma zedoary 7g, root of Dahurain angelica 7g and tomentosecalyx elsholtzia leaf 7g, at every turn stifling 30～50 minutes, each 1 time sooner or later, to treat after 1 week, patient's nasal secretion obviously reduces, and adheres to using 3 courses for the treatment of (4Zhou Weiyi the course for the treatment of) after, transference cure, recovery from illness, favourable prognosis.
2, this Chinese medicine composition gelata In Vitro Bacteriostasis experiment
Object: the antibacterial action of evaluating medicine of the present invention by the bacteriostatic test of medicine.
Method: adopt twice serial dilution to evaluate the In Vitro Bacteriostasis of gel in the embodiment of the present invention 5.
Table 1 medicine of the present invention is the bacteriostatic test result with reference culture to test
| Drug concentration* | Escherichia coli | Staphylococcus aureus | Pneumococcus | Candida albicans |
| 4％ | - | - | - | - |
| 2％ | - | - | (-) | - |
| 1％ | - | - | + | (-) |
| 0.5％ | - | - | + | + |
| 0.25％ | (-) | (-) | + | + |
| 0.125％ | + | + | + | + |
+ expression test pipe range bacterium; The long bacterium of-expression developmental tube; (-) is minimum inhibitory concentration;
*Drug concentration calculates with the concentration of volume percent of contained volatile oil.
Result: patent gel preparation of the present invention to the minimum inhibitory concentration of Escherichia coli, staphylococcus aureus with contained volatilizationOil counts 0.25%, and pneumococcal minimum inhibitory concentration is counted to 2% with contained volatile oil, and the minimum of Candida albicans pressed downBacteria concentration counts 1% with contained volatile oil. Show that this preparation is to Escherichia coli, staphylococcus aureus, pneumococcus, whiteCandida albicans is inhibited.
3, the prepared volatile oil of this Chinese medicine composition and the experiment of gel anti-inflammatory
Object: for the effect of checking this product to rhinitis chronic, select the granulation tissue hyperplasia similar to the pathological change of inflammation later stage,Observe its antiinflammatory action.
Method: get 60 of SD rats, be divided at random blank group, dexamethasone positive controls, 1% volatile oil, 3%Volatile oil, 5% volatile oil and gel group, totally 6 groups, volatile oil solution preparation method prepares for getting this Chinese medicine compositionVolatile oil, be diluted to volatile oil with the rilanit special APEO of 1:1 and sodium sulfate of polyethenoxy ether of fatty alcohol and containAmount is respectively 5%, 3%, 1% concentration liquid. By rat right part oxter unhairing, 75% ethanol disinfection, does an otch, subcutaneousInsert a high-temperature sterilization cotton balls, sew up subsequently, start coating after 24h, every day 3 times, successive administration, will be large after 7 daysMouse is put to death, and takes out granuloma induced by implantation of cotton pellets tissue, and adipose tissue is peeled off in carefulness, puts 60 DEG C of dry 4h, calculates granulation tissue weightWith granulation inhibiting rate.
Table 2 medicine of the present invention is on the granulomatous impact of mouse
With model control group comparison (t inspection): * * p < 0.05, * * * p < 0.01.
Result shows: high, normal, basic 3 the dosage volatile oil of the present invention and gel have obvious inhibition to do to mouse granuloma induced by implantation of cotton pelletsIncrease with dosage and increase with, inhibiting rate.
Preparation of the present invention has effect of awakening consciousness, promoting qi circulation and removing obstruction in the collateral, blood stasis-eliminating and stagnation-dissipating, for preventing and treating rhinitis chronic, especially slowProperty rhinitis syndrome of blood stasis type effect remarkable, overcome the limitation that Western medicine target spot is single, treatment rhinitis chronic good effect, cure rate are high.
The above embodiment of the present invention is to be only explanation example of the present invention, and not to embodiments of the present inventionLimit. For those of ordinary skill in the field, can also make on the basis of the above description that other are multi-formChange and variation. Everyly belong to apparent variation or the variation that technical scheme of the present invention is amplified out, still belong to the present inventionThe row of protection domain.
Claims (10)
1. a Chinese medicine composition for the treatment of rhinitis chronic, is characterized in that, the each flavour of a drug of Chinese medicine composition are made up of the ratio of following weight proportion: 5～8 parts of 7～12 parts of the flower buds of lily magnolia, 6～11 parts of curcuma zedoarys, 5～8 parts of the roots of Dahurain angelica and tomentosecalyx elsholtzia leafs.
2. treat according to claim 1 the Chinese medicine composition of rhinitis chronic, in preferred said composition, the weight proportion ratio of each flavour of a drug is as follows respectively:
6 parts of 10 parts of the flower buds of lily magnolia, 9 parts of curcuma zedoarys, 6 parts of the roots of Dahurain angelica and tomentosecalyx elsholtzia leafs.
3. a treatment rhinitis chronic Chinese medicine preparation, is characterized in that, is prepared into conventional nasal cavity external preparation by Chinese medicine composition described in claim 1 or 2 after extracting volatile oil.
4. a preparation method who treats rhinitis chronic Chinese medicine preparation, is characterized in that, comprises the steps:
1) take the flower bud of lily magnolia, curcuma zedoary, the root of Dahurain angelica and tomentosecalyx elsholtzia leaf by proportioning described in claim 1 or 2, adopt steam distillation or supercritical extraction method to extract and obtain volatile oil;
2) by the above-mentioned volatile oil of collecting, add pharmaceutically acceptable auxiliary material or complementary composition, be prepared into aromatic waters for nasal cavity, spray, gel or aerosol.
5. the preparation method of Chinese medicine preparation according to claim 4, is characterized in that, the extracting mode of volatile oil is following 1) or 2) either method:
1) described steam distillation method is: the flower bud of lily magnolia, curcuma zedoary, the root of Dahurain angelica and tomentosecalyx elsholtzia leaf are taken by formula, add 4～10 times of water gagings of medicinal material weight, soak 0～2 hour, the distillation mode cohobation of straight-through Steam Heating or directly heating decoction 4～7 hours, collects and obtains volatile oil;
2) described supercritical extraction method is: the flower bud of lily magnolia, curcuma zedoary, the root of Dahurain angelica and tomentosecalyx elsholtzia leaf are taken and are ground into coarse granule by formula, carbon dioxide supercritical extraction 2～6 hours, obtains the volatile oil of said preparation; Wherein extraction conditions is: extracting pressure 20～35MPa, 30～40 DEG C of extraction temperature, carbon dioxide flow: 300～600L/h.
6. treat a preparation method for rhinitis chronic gel, it is that the volatile oil obtaining by claim 5 is raw material, further prepare and gel.
7. the preparation method who treats according to claim 6 rhinitis chronic gel, is characterized in that, comprises the following steps: get 1 part of volatile oil, add 0.5～4 part, surfactant, 0.005～0.1 part of ground and mixed of bacteriostatic agent is even; Add the aqueous solution containing 0.1～1 part of zinc gluconate, 0.1～0.5 part, sodium chloride, 0.2～2 part of glycerine, stir, make each composition emulsification, dissolve, be uniformly dispersed; Add again 2～10 parts of gel-type vehicles after swelling treatment, and mend and add water to configuration total amount, be uniformly mixed and form.
8. the preparation method who treats according to claim 7 rhinitis chronic gel, is characterized in that: the described gel-type vehicle after swelling treatment is the gel-type vehicle that sodium carboxymethylcellulose or carbomer add swelling treatment gained after 15～25 times of water gagings.
9. the preparation method who treats according to claim 7 rhinitis chronic gel, is characterized in that: described bacteriostatic agent is methyl hydroxybenzoate or ethylparaben.
10. the preparation method who treats according to claim 7 rhinitis chronic gel, is characterized in that: described surfactant is Tween-80, Tween-60, rilanit special APEO or sodium sulfate of polyethenoxy ether of fatty alcohol.
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| CN115326647A (en) * | 2022-04-28 | 2022-11-11 | 西安石油大学 | surfactant-CO 2 Method for researching behavior of crude oil miscible interface |
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| CN1408358A (en) * | 2002-09-20 | 2003-04-09 | 高艺歌 | Recipe component of zinc gluconate colloid nose spray |
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