CN114105923A - 一种s-构型玻色因晶型化合物及其制备方法 - Google Patents
一种s-构型玻色因晶型化合物及其制备方法 Download PDFInfo
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- CN114105923A CN114105923A CN202111556250.XA CN202111556250A CN114105923A CN 114105923 A CN114105923 A CN 114105923A CN 202111556250 A CN202111556250 A CN 202111556250A CN 114105923 A CN114105923 A CN 114105923A
- Authority
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- China
- Prior art keywords
- configuration
- crystal
- compound
- boscalid
- vitronectin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000013078 crystal Substances 0.000 title claims abstract description 84
- 150000001875 compounds Chemical class 0.000 title claims abstract description 53
- 108010031318 Vitronectin Proteins 0.000 title claims abstract description 31
- 102100035140 Vitronectin Human genes 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title claims description 14
- 239000005740 Boscalid Substances 0.000 claims abstract description 27
- 229940118790 boscalid Drugs 0.000 claims abstract description 27
- WYEMLYFITZORAB-UHFFFAOYSA-N boscalid Chemical compound C1=CC(Cl)=CC=C1C1=CC=CC=C1NC(=O)C1=CC=CN=C1Cl WYEMLYFITZORAB-UHFFFAOYSA-N 0.000 claims abstract description 26
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 28
- 238000000034 method Methods 0.000 claims description 14
- 239000002904 solvent Substances 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 238000010438 heat treatment Methods 0.000 claims description 12
- 238000001914 filtration Methods 0.000 claims description 11
- 238000000634 powder X-ray diffraction Methods 0.000 claims description 10
- 210000004027 cell Anatomy 0.000 claims description 9
- 238000002156 mixing Methods 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 7
- 239000002537 cosmetic Substances 0.000 claims description 4
- 210000002858 crystal cell Anatomy 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 16
- 239000007787 solid Substances 0.000 description 15
- 235000019441 ethanol Nutrition 0.000 description 14
- 238000003756 stirring Methods 0.000 description 10
- 238000005406 washing Methods 0.000 description 9
- 238000010521 absorption reaction Methods 0.000 description 8
- 238000001291 vacuum drying Methods 0.000 description 7
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical group ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
- 229920002683 Glycosaminoglycan Polymers 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 6
- 238000003786 synthesis reaction Methods 0.000 description 6
- -1 boscalid compound Chemical class 0.000 description 5
- 238000001816 cooling Methods 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 4
- 238000002447 crystallographic data Methods 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 230000003287 optical effect Effects 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 238000002441 X-ray diffraction Methods 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 125000003158 alcohol group Chemical group 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 238000012937 correction Methods 0.000 description 2
- 239000008406 cosmetic ingredient Substances 0.000 description 2
- 210000004207 dermis Anatomy 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 229910002804 graphite Inorganic materials 0.000 description 2
- 239000010439 graphite Substances 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 238000005984 hydrogenation reaction Methods 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000012454 non-polar solvent Substances 0.000 description 2
- 239000003208 petroleum Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 210000003491 skin Anatomy 0.000 description 2
- KOGFZZYPPGQZFZ-QVAPDBTGSA-N (2s,3r,4s,5r)-2-(2-hydroxypropyl)oxane-3,4,5-triol Chemical compound CC(O)C[C@@H]1OC[C@@H](O)[C@H](O)[C@H]1O KOGFZZYPPGQZFZ-QVAPDBTGSA-N 0.000 description 1
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 239000003365 glass fiber Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Birds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
Abstract
Description
原子-原子-原子 | 键角(°) | 原子-原子-原子 | 键角(°) |
C(1)-O(1)-C(5) | 112.6(3) | C(3)-C(4)-C(5) | 111.9(4) |
O(1)-C(1)-C(2) | 110.1(4) | O(1)-C(5)-C(6) | 108.1(4) |
O(2)-C(2)-C(3) | 111.1(4) | O(1)-C(5)-C(4) | 108.3(4) |
O(2)-C(2)-C(1) | 110.9(4) | C(6)-C(5)-C(4) | 113.5(4) |
C(3)-C(2)-C(1) | 111.0(4) | C(7)-C(6)-C(5) | 115.2(4) |
C(2)-C(3)-C(4) | 110.9(4) | O(4)-C(7)-C(8) | 107.8(4) |
O(3)-C(4)-C(3) | 107.4(4) | O(4)-C(7)-C(6) | 111.0(4) |
O(3)-C(4)-C(5) | 110.5(4) | C(8)-C(7)-C(6) | 113.0(5) |
O(003)-C(3)-C(2) | 107.1(4) | O(003)-C(3)-C(4) | 111.0(4) |
Claims (10)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202111556250.XA CN114105923A (zh) | 2021-12-17 | 2021-12-17 | 一种s-构型玻色因晶型化合物及其制备方法 |
PCT/CN2022/099659 WO2023109057A1 (zh) | 2021-12-17 | 2022-06-20 | 一种s-构型玻色因晶型化合物及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202111556250.XA CN114105923A (zh) | 2021-12-17 | 2021-12-17 | 一种s-构型玻色因晶型化合物及其制备方法 |
Publications (1)
Publication Number | Publication Date |
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CN114105923A true CN114105923A (zh) | 2022-03-01 |
Family
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Family Applications (1)
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CN202111556250.XA Pending CN114105923A (zh) | 2021-12-17 | 2021-12-17 | 一种s-构型玻色因晶型化合物及其制备方法 |
Country Status (2)
Country | Link |
---|---|
CN (1) | CN114105923A (zh) |
WO (1) | WO2023109057A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023109057A1 (zh) * | 2021-12-17 | 2023-06-22 | 深圳瑞德林生物技术有限公司 | 一种s-构型玻色因晶型化合物及其制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IN202041033352A (zh) * | 2020-08-04 | 2020-10-02 | ||
CN113735811B (zh) * | 2021-11-03 | 2022-02-08 | 深圳瑞德林生物技术有限公司 | 一种通过酰化保护再还原合成玻色因的方法 |
CN114105923A (zh) * | 2021-12-17 | 2022-03-01 | 深圳瑞德林生物技术有限公司 | 一种s-构型玻色因晶型化合物及其制备方法 |
-
2021
- 2021-12-17 CN CN202111556250.XA patent/CN114105923A/zh active Pending
-
2022
- 2022-06-20 WO PCT/CN2022/099659 patent/WO2023109057A1/zh unknown
Non-Patent Citations (1)
Title |
---|
狄磊勤等: "破译欧莱雅"玻色因"的"黑匣子"", 《乐山师范学院》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023109057A1 (zh) * | 2021-12-17 | 2023-06-22 | 深圳瑞德林生物技术有限公司 | 一种s-构型玻色因晶型化合物及其制备方法 |
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Publication number | Publication date |
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WO2023109057A1 (zh) | 2023-06-22 |
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Address after: 518000 floor 3, building 2, Shenzhen biological incubation base, No. 10, Gaoxin Zhongyi Road, Maling community, Yuehai street, Nanshan District, Shenzhen, Guangdong Applicant after: SHENZHEN READLINE BIOTECHNOLOGY Co.,Ltd. Address before: 518000 Room 101, 1st floor, building 2, Shenzhen biological incubation base, No.10, Gaoxin middle 1st Road, Maling community, Yuehai street, Nanshan District, Shenzhen City, Guangdong Province Applicant before: SHENZHEN READLINE BIOTECHNOLOGY Co.,Ltd. |
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Application publication date: 20220301 |