CN114007621A - 用于治疗慢性肺同种异体移植物功能障碍的jak1途径抑制剂 - Google Patents
用于治疗慢性肺同种异体移植物功能障碍的jak1途径抑制剂 Download PDFInfo
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- CN114007621A CN114007621A CN202080024215.0A CN202080024215A CN114007621A CN 114007621 A CN114007621 A CN 114007621A CN 202080024215 A CN202080024215 A CN 202080024215A CN 114007621 A CN114007621 A CN 114007621A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
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|---|---|---|---|
| US201962814085P | 2019-03-05 | 2019-03-05 | |
| US62/814,085 | 2019-03-05 | ||
| PCT/US2020/021088 WO2020181034A1 (en) | 2019-03-05 | 2020-03-05 | Jak1 pathway inhibitors for the treatment of chronic lung allograft dysfunction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114007621A true CN114007621A (zh) | 2022-02-01 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN202080024215.0A Pending CN114007621A (zh) | 2019-03-05 | 2020-03-05 | 用于治疗慢性肺同种异体移植物功能障碍的jak1途径抑制剂 |
Country Status (15)
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|---|---|
| US (2) | US11406640B2 (https=) |
| EP (2) | EP3934651A1 (https=) |
| JP (2) | JP2022524997A (https=) |
| KR (1) | KR20210137087A (https=) |
| CN (1) | CN114007621A (https=) |
| AU (1) | AU2020232757B2 (https=) |
| CA (1) | CA3132371A1 (https=) |
| EA (1) | EA202192426A1 (https=) |
| IL (1) | IL285999B2 (https=) |
| MA (1) | MA55201A (https=) |
| MX (2) | MX2021010545A (https=) |
| PH (1) | PH12021552130A1 (https=) |
| SG (1) | SG11202109563WA (https=) |
| UA (1) | UA130579C2 (https=) |
| WO (1) | WO2020181034A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3837258T (pt) | 2018-09-04 | 2024-06-20 | Theravance Biopharma R&D Ip Llc | Amidas de dimetil amino azetidina como inibidores de jak |
| WO2020051139A1 (en) | 2018-09-04 | 2020-03-12 | Theravance Biopharma R&D Ip, Llc | 5 to 7 membered heterocyclic amides as jak inhibitors |
| MX2021004582A (es) | 2018-10-29 | 2021-06-15 | Theravance Biopharma R&D Ip Llc | Compuesto 2-azabiciclo hexano inhibidor de jak. |
| CA3117969A1 (en) | 2018-10-31 | 2020-05-07 | Incyte Corporation | Combination therapy for treatment of hematological diseases |
| MA55201A (fr) * | 2019-03-05 | 2022-01-12 | Incyte Corp | Inhibiteurs de la voie jak1 pour le traitement d'un dysfonctionnement chronique de l'allogreffe pulmonaire |
| US11992490B2 (en) | 2019-10-16 | 2024-05-28 | Incyte Corporation | Use of JAK1 inhibitors for the treatment of cutaneous lupus erythematosus and Lichen planus (LP) |
| TW202144343A (zh) | 2020-03-02 | 2021-12-01 | 美商施萬生物製藥研發 Ip有限責任公司 | Jak抑制劑化合物之結晶水合物 |
| EP4274578A1 (en) * | 2021-01-11 | 2023-11-15 | Incyte Corporation | Combination therapy comprising jak pathway inhibitor and rock inhibitor |
| TW202317550A (zh) | 2021-06-25 | 2023-05-01 | 美商施萬生物製藥研發 Ip有限責任公司 | 作為jak抑制劑之咪唑吲唑化合物 |
| KR102952944B1 (ko) | 2021-10-15 | 2026-04-14 | 주식회사 엘지에너지솔루션 | 용접봉 체결 방법 및 이에 의해 용접봉이 수직으로 체결된 용접 장치 |
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| US20150118229A1 (en) * | 2013-10-24 | 2015-04-30 | Abbvie Inc. | Jak1 selective inhibitor and uses thereof |
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| CN105579032A (zh) * | 2013-08-07 | 2016-05-11 | 因赛特公司 | Jak1抑制剂的持续释放剂型 |
| CN106456773A (zh) * | 2014-02-28 | 2017-02-22 | 因赛特公司 | 用于治疗骨髓增生异常综合征的jak1抑制剂 |
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-
2020
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- 2020-03-05 UA UAA202105585A patent/UA130579C2/uk unknown
- 2020-03-05 AU AU2020232757A patent/AU2020232757B2/en active Active
- 2020-03-05 EA EA202192426A patent/EA202192426A1/ru unknown
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- 2020-03-05 CN CN202080024215.0A patent/CN114007621A/zh active Pending
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- 2020-03-05 EP EP25213638.7A patent/EP4691567A3/en active Pending
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2021
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2022
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2025
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Also Published As
| Publication number | Publication date |
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| AU2020232757A1 (en) | 2021-10-07 |
| EP4691567A3 (en) | 2026-04-29 |
| WO2020181034A1 (en) | 2020-09-10 |
| JP2022524997A (ja) | 2022-05-11 |
| MX2024007081A (es) | 2024-06-21 |
| MA55201A (fr) | 2022-01-12 |
| SG11202109563WA (en) | 2021-09-29 |
| EP3934651A1 (en) | 2022-01-12 |
| IL285999B1 (en) | 2025-09-01 |
| CA3132371A1 (en) | 2020-09-10 |
| PH12021552130A1 (en) | 2022-08-31 |
| KR20210137087A (ko) | 2021-11-17 |
| EP4691567A2 (en) | 2026-02-11 |
| UA130579C2 (uk) | 2026-03-25 |
| IL285999B2 (en) | 2026-01-01 |
| US20220331325A1 (en) | 2022-10-20 |
| MX2021010545A (es) | 2021-11-17 |
| IL285999A (en) | 2021-10-31 |
| US11406640B2 (en) | 2022-08-09 |
| JP2025087734A (ja) | 2025-06-10 |
| US20200281931A1 (en) | 2020-09-10 |
| EA202192426A1 (ru) | 2021-11-15 |
| US11896595B2 (en) | 2024-02-13 |
| AU2020232757B2 (en) | 2025-09-11 |
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