CN114007604A - 含有紫杉叶素的肝纤维化抑制剂和褐色脂肪细胞活化剂 - Google Patents
含有紫杉叶素的肝纤维化抑制剂和褐色脂肪细胞活化剂 Download PDFInfo
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- CN114007604A CN114007604A CN202080046429.8A CN202080046429A CN114007604A CN 114007604 A CN114007604 A CN 114007604A CN 202080046429 A CN202080046429 A CN 202080046429A CN 114007604 A CN114007604 A CN 114007604A
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Abstract
Description
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20130267477A1 (en) * | 2012-04-10 | 2013-10-10 | Flavitpure, Inc. | Method of using nutritional compounds dihydroquercetin (taxifolin) and arabinogalactan in combination with dihydroquercetin (taxifolin) to reduce and control cardiometabolic risk factors associated with metabolic syndrome and hypercholesterolemia |
US20180117003A1 (en) * | 2015-11-19 | 2018-05-03 | Sinew Pharma Inc. | Methods and compositions for preventing or treating fatty liver, protecting liver function or ameliorating liver diseases caused by fatty liver or other associated disorders |
JP2018131429A (ja) * | 2017-02-14 | 2018-08-23 | 拓己 佐藤 | Nrf2活性化剤の効果を増強する方法としての有機酸の使用 |
IL261670A (en) * | 2018-09-06 | 2018-10-31 | Tudu Holdings Ltd | A preparation that includes magnesium and its uses |
CN108721272A (zh) * | 2018-05-28 | 2018-11-02 | 湖北民族学院 | 一种新型抗纤维化药物及动物模型的构建方法 |
CN109771411A (zh) * | 2018-11-19 | 2019-05-21 | 延边大学 | 二氢槲皮素用于制备治疗脂肪肝的药物中的用途 |
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CN102477453A (zh) * | 2010-11-22 | 2012-05-30 | 天津药物研究院 | 一种从黄杞叶中制备花旗松素单体的方法及用途 |
KR102181657B1 (ko) | 2016-05-19 | 2020-11-23 | 고쿠리츠켄큐카이하츠호진 고쿠리츠쥰칸키뵤 겐큐센터 | 치매의 예방 및/또는 치료를 위한 약물 |
JP2019117229A (ja) | 2017-12-26 | 2019-07-18 | 東京応化工業株式会社 | レジスト組成物及びレジストパターン形成方法 |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20130267477A1 (en) * | 2012-04-10 | 2013-10-10 | Flavitpure, Inc. | Method of using nutritional compounds dihydroquercetin (taxifolin) and arabinogalactan in combination with dihydroquercetin (taxifolin) to reduce and control cardiometabolic risk factors associated with metabolic syndrome and hypercholesterolemia |
US20180117003A1 (en) * | 2015-11-19 | 2018-05-03 | Sinew Pharma Inc. | Methods and compositions for preventing or treating fatty liver, protecting liver function or ameliorating liver diseases caused by fatty liver or other associated disorders |
JP2018131429A (ja) * | 2017-02-14 | 2018-08-23 | 拓己 佐藤 | Nrf2活性化剤の効果を増強する方法としての有機酸の使用 |
CN108721272A (zh) * | 2018-05-28 | 2018-11-02 | 湖北民族学院 | 一种新型抗纤维化药物及动物模型的构建方法 |
IL261670A (en) * | 2018-09-06 | 2018-10-31 | Tudu Holdings Ltd | A preparation that includes magnesium and its uses |
CN109771411A (zh) * | 2018-11-19 | 2019-05-21 | 延边大学 | 二氢槲皮素用于制备治疗脂肪肝的药物中的用途 |
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JP7058031B2 (ja) | 2022-04-21 |
EP3991728A1 (en) | 2022-05-04 |
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