CN113967251B

CN113967251B - Bacteriostatic agent, hand sanitizer containing bacteriostatic agent and preparation method of hand sanitizer

Info

Publication number: CN113967251B
Application number: CN202111176185.8A
Authority: CN
Inventors: 田佩东; 李全红; 屈忠安
Original assignee: Shandong Kaipurun Disinfecting Technology Co ltd
Current assignee: Shandong Kaipurun Disinfecting Technology Co ltd
Priority date: 2021-10-09
Filing date: 2021-10-09
Publication date: 2022-12-02
Anticipated expiration: 2041-10-09
Also published as: CN113967251A

Abstract

The application relates to the technical field of hand sanitizer, and particularly discloses a bacteriostatic agent, a hand sanitizer containing the bacteriostatic agent and a preparation method of the hand sanitizer. A bacteriostatic agent consists of the following raw materials: plant extract, lysozyme, pine oil, benzalkonium bromide, a penetration aid and water. A hand sanitizer containing a bacteriostatic agent comprises the following raw materials: bacteriostatic agent, nicandra physaloides seed colloidal polysaccharide, nano activated carbon, nano silver colloid, thickening agent, skin care agent, detergent, essence, pH regulator and water. The raw materials in the application are mostly natural products and are less toxic, so that the product has the characteristic of environmental protection; meanwhile, the hand sanitizer has a lasting bacteriostatic effect.

Description

Bacteriostatic agent, hand sanitizer containing bacteriostatic agent and preparation method of hand sanitizer

Technical Field

The application relates to the technical field of hand sanitizer, in particular to a bacteriostatic agent, a hand sanitizer containing the bacteriostatic agent and a preparation method of the hand sanitizer.

Background

With the threat of various diseases to human health, people pay more and more attention to personal hygiene conditions. In daily life, hands are in the closest contact with the outside, and the hands are in more contact with eyes, oral cavities and the like, so that the hand disinfection is very important. The hand sanitizer is a skin care cleansing liquid mainly for cleaning hands, and specific components contained in the hand sanitizer can play a role in disinfection and sterilization.

However, the residual quantity of bacteriostatic components in the hand sanitizer after flushing is small, so that the bacteriostatic duration of the hand sanitizer is poor.

Disclosure of Invention

In order to achieve the effect of lasting bacteriostasis, the application provides a bacteriostat, a hand sanitizer containing the bacteriostat and a preparation method thereof.

In a first aspect, the application provides a bacteriostatic agent, which adopts the following technical scheme:

the bacteriostatic agent is composed of the following raw materials in percentage by mass, based on 100% by mass: 6.9 to 8.6 percent of plant extract, 2 to 4.7 percent of lysozyme, 7.5 to 9.3 percent of pine oil, 2.8 to 5 percent of benzalkonium bromide, 5 to 8 percent of penetration assistant and the balance of water.

By adopting the technical scheme, the pine oil is an organic oily substance slightly soluble in water, and meanwhile, the pine oil has good emulsification, wettability and permeability. Therefore, the bacteriostatic agent added with the pine oil can form a film on the surface of the skin, so that the plant extract, the lysozyme and the benzalkonium bromide in the system are attached to the film, thereby prolonging the retention time of each bacteriostatic active substance on the skin and achieving the effect of lasting bacteriostasis. And the pine oil has the functions of antibiosis and antiphlogosis, so that the bacteriostasis effect of the system can be further improved.

Meanwhile, the plant extract contains various antibacterial active substances, such as volatile oil, alkaloid, flavonoid, phenol alcohol, quinones, saponin, glucoside and the like, has a good inhibition effect on bacteria, and has a broad-spectrum antibacterial effect. The plant extract is a natural raw material, is green and environment-friendly, and has small influence on the environment; meanwhile, the product is mild in property and less harmful to human bodies.

Lysozyme is an enzyme capable of hydrolyzing mucopolysaccharide in pathogenic bacteria, and lysozyme can decompose bacterial cell walls into soluble glycopeptide to cause the bacterial cell walls to break, thereby achieving the bacteriostatic effect. The lysozyme has good stability and excellent bacteriostatic effect in various environments; meanwhile, the lysozyme is an inherent substance in the human body, so that the lysozyme basically has no harm to the human body.

Benzalkonium bromide is a cationic surfactant, has the functions of decontamination and broad-spectrum bacteriostasis, and is added into a system to complement the bacteriostasis effect of the system, namely natural bacteriostasis substances are combined with inorganic bacteriostasis substances to improve the bacteriostasis effect of the bacteriostat system.

Meanwhile, the penetration auxiliary agent is added into the system, so that the penetration effect of the bacteriostatic active substance on bacteria can be improved, and the bacteriostatic effect of the system is improved.

Preferably, the plant extract comprises one or more of purslane extract, tea extract, dryopteris fragrans extract, bamboo leaf extract, emblic leafflower fruit extract and artemisia argyi extract.

By adopting the technical scheme, the purslane, the tea, the dryopteris fragrans, the bamboo leaves, the phyllanthus emblica and the artemisia argyi belong to natural plants, and extracts of the natural plants contain more antibacterial active substances such as volatile oil, alkaloid, flavonoid, phenolic alcohol, quinones, saponin, glucoside and the like, so that the bacterial activity can be effectively inhibited. Meanwhile, the nature of each natural plant extract is mild, the damage to human bodies is small, and the green environmental protection is realized.

Preferably, the penetration auxiliary agent is one or two of soybean lecithin and fatty alcohol-polyoxyethylene ether.

By adopting the technical scheme, the soybean lecithin is the phospholipid forming the biological membrane, so that the penetration of antibacterial active substances into bacteria can be promoted, and the antibacterial effect is improved. The fatty alcohol-polyoxyethylene ether is a nonionic surfactant and can promote bacteriostatic active substances to permeate into bacteria, so that the bacteriostatic effect is improved.

In a second aspect, the application provides a hand sanitizer containing a bacteriostatic agent, which adopts the following technical scheme:

the hand sanitizer containing the bacteriostatic agent is 100% in mass and comprises the following raw materials in percentage by mass: 0.8 to 2 percent of bacteriostatic agent, 1.3 to 2.6 percent of nicandra physaloides seed colloidal polysaccharide, 0.3 to 0.7 percent of nano activated carbon, 0.05 to 0.08 percent of nano silver colloid, 0.6 to 1.3 percent of thickening agent, 0.4 to 0.9 percent of skin care agent, 1.5 to 2.5 percent of detergent, 0.02 to 0.05 percent of essence and the balance of other auxiliary agents.

By adopting the technical scheme, the nicandra physaloides seed colloidal polysaccharide is sol formed after nicandra physaloides seeds are soaked in water, and after the nicandra physaloides seed colloidal polysaccharide is mixed with the nano activated carbon, a smooth colloidal film can be formed on the pores and the surface of the nano activated carbon. The nano activated carbon has better adsorption effect and larger specific surface area, the colloidal film is matched with the nano activated carbon to form a carrier of the antibacterial active substance, and the antibacterial active substance is adsorbed and attached to the carrier; meanwhile, the adhesive effect of a colloidal film formed by the nicandra physaloides seed colloidal polysaccharide on the skin is good, so that the retention time of a carrier formed by the colloidal film and the nano activated carbon on the skin is prolonged, the retention time of the antibacterial active substance on the skin is longer, and the lasting antibacterial effect is achieved. Meanwhile, the nicandra physaloides seed colloid polysaccharide is a natural product, is green and environment-friendly, can weaken the granular sensation of the nano activated carbon in the hand sanitizer, and improves the comfort of hand washing.

The nano silver colloid is attached to the surface of a carrier formed by the colloid film and the nano activated carbon to form a nano silver film; when bacteria contact skin, silver ions in the nano silver film act with the bacteria, so that the nano silver film is broken, and antibacterial active substances on the carrier are released for bacteriostasis. The silver ions are matched with the antibacterial active substance, so that the antibacterial effect is improved, and meanwhile, the natural loss of the antibacterial active substance before contacting bacteria is reduced, and the lasting antibacterial effect is achieved.

Preferably, the other auxiliary agents comprise a pH regulator and water, wherein the pH regulator comprises one or more of tartaric acid, citric acid and malic acid.

By adopting the technical scheme, the pH value of the system is adjusted by the pH regulator, so that the pH value of the system is in a range suitable for the bacteriostatic active substance and the human skin.

Preferably, the thickening agent comprises one or two of hydroxypropyl methylcellulose and pectin.

By adopting the technical scheme, the hydroxypropyl methyl cellulose has good thickening property, water retention property and excellent film forming property; pectin is extracted from plant cells, and the pectin and the plant cells can improve the viscosity of a system when added into the system, so that the experience feeling in the hand washing process is improved.

Preferably, the skin care agent comprises one or both of glycerin and lanolin.

By adopting the technical scheme, the glycerin is a polyalcohol and has the effects of moisturizing and moistening the skin, and the lanolin is a sticky and greasy substance and can supplement skin grease, so that the dry and rough skin caused by using the hand sanitizer is reduced.

Preferably, the detergent comprises one or more of cocamidopropyl betaine, alkyl glycoside, lauramidopropyl betaine.

By adopting the technical scheme, the cocoamidopropyl betaine is a zwitterionic surfactant and has good decontamination effect, hard water resistance and antibacterial property; the alkyl glycoside has the characteristics of strong detergency, small irritation, strong hard water resistance and the like; the lauramidopropyl betaine is an amphoteric surfactant with extremely low irritation, and has good antibacterial property, detergency and stability. The three can improve the decontamination effect of the hand sanitizer and reduce the stimulation of the hand sanitizer to human skin, and meanwhile, the three have good biodegradability, small influence on the environment and environmental protection.

In a third aspect, the application provides a preparation method of a hand sanitizer containing a bacteriostatic agent, which adopts the following technical scheme:

a preparation method of a hand sanitizer containing a bacteriostatic agent comprises the following steps:

preparing a bacteriostatic agent: adding plant extract, lysozyme, benzalkonium bromide and pine oil into water, mixing, stirring, adding penetration assistant, and stirring to obtain antibacterial agent;

pretreating a bacteriostatic agent: mixing and stirring nano activated carbon and the prepared nicandra physaloides seed colloidal polysaccharide, then adding the prepared bacteriostatic agent, continuing stirring, standing, adding the nano silver colloid, mixing and stirring to prepare a mixture for later use;

preparing a hand sanitizer: adding thickener, skin care agent, detergent and water into the mixture, mixing, stirring, adding pH regulator to regulate pH value of the system, and making into hand sanitizer.

By adopting the technical scheme, the nicandra physaloides seed colloidal polysaccharide and the nano activated carbon are mixed and stirred in advance, so that the nicandra physaloides seed colloidal polysaccharide is adhered to pores and the surface of the nano activated carbon to form a smooth colloidal membrane; then adding bacteriostatic agent, mixing and stirring to make bacteriostatic active substance be attached to the carrier formed by matching colloidal membrane with nano active carbon; and adding nano silver colloid to form a layer of nano silver film on the surface of the carrier, and coating the carrier. Thereby improving the stability of the bacteriostatic active substance on the carrier and simultaneously improving the bacteriostatic durability of the prepared hand sanitizer.

Preferably, the pH of the system is adjusted to 6.5-6.8 in the hand sanitizer preparation step.

By adopting the technical scheme, the pH value of the system is adjusted to 6.5-6.8, the stability of the system is improved, and meanwhile, an adaptive acid-base environment is provided for each bacteriostatic active substance, so that the bacteriostatic effect is improved; and the pH value of the hand sanitizer with the pH value of 6.5-6.8 is similar to the pH value of a human body, so that the damage of the hand sanitizer to the skin of the human body is reduced.

In summary, the present application has the following beneficial effects:

1. plant extract, lysozyme, pine oil and benzalkonium bromide are adopted as the bacteriostatic active substances of the bacteriostatic agent, and the plant extract, the lysozyme and the benzalkonium bromide are attached to the pine oil, so that the pine oil forms a film on the skin of a human body, the attaching effect of each bacteriostatic active substance on the skin of the human body is better, and the lasting bacteriostatic effect is achieved.

2. According to the application, the nicandra physaloides seed colloidal polysaccharide and the nano activated carbon are mixed to form a carrier of the antibacterial active substance, so that the antibacterial active substance is stably attached to the carrier, and a nano silver film is formed on the carrier through the nano silver colloid. As the nicandra physaloides seed colloid polysaccharide forms a smooth colloid film on the skin of a human body, when the skin contacts bacteria, silver ions in the nano silver film firstly act with the bacteria to inhibit the activity of the bacteria, and the nano silver film contacting the bacteria breaks to release bacteriostatic active substances on a carrier for bacteriostasis, thereby achieving the effect of lasting bacteriostasis and simultaneously improving the bacteriostasis effect.

3. According to the method for preparing the hand sanitizer, the pH of a system is adjusted to 6.5-6.8 through the pH regulator, so that the stability of antibacterial active substances in the system is improved, and the damage of the prepared hand sanitizer to human skin is reduced.

Detailed Description

The present application will be described in further detail below by way of examples and comparative examples.

The starting materials for this example, with the exception of the nicandra physaloides seed gum polysaccharide, were commercially available, with the purslane extract being obtained from the Western Wanfang Biotech Co., ltd under the designation 03;

the bamboo leaf extract is obtained from Sienna Wood fruit Biotech limited, and has a product number of MG-21080308;

the folium Artemisiae Argyi extract is produced by Shanxi Bangcheng Biotechnology GmbH, with a product number of SXBC0443;

soybean lecithin is produced by Siam Siji Biotech, inc. under the product number sj;

the fatty alcohol-polyoxyethylene ether is produced by Shandong Fujia chemical Co., ltd, and has a product number of 6695;

hydroxypropyl methylcellulose is produced by chemical ltd, hua liter, dennan, under the product number 6;

lanolin is produced from Guangzhou Guangdong Cheng chemical Co., ltd, with a product number of 001;

the alkyl glycoside is available from Jie-Chu chemical Co., ltd, guangzhou under the product number 0810.

Preparation example of bacteriostatic agent

Preparation example 1

A bacteriostatic agent, 5kg of bacteriostatic agent finished product is composed of the following raw materials by mass: 0.345kg of plant extract, 0.1kg of lysozyme, 0.375kg of pine oil, 0.14kg of benzalkonium bromide, 0.25kg of permeation assistant and the balance of water.

The plant extract is a mixture consisting of a purslane extract, a bamboo leaf extract and an artemisia argyi extract according to the mass ratio of 2;

the penetration auxiliary agent is a mixture of soybean lecithin and fatty alcohol-polyoxyethylene ether according to the mass ratio of 1.

A preparation method of a bacteriostatic agent comprises the following steps:

mixing plant extract, lysozyme and oleum Pini under stirring at 600rpm for 15min at 25 deg.C; then keeping the stirring speed and the stirring temperature unchanged, adding benzalkonium bromide, and continuing stirring for 10min; adding penetration assistant and water, and stirring for 20min to obtain the antibacterial agent.

Preparation example 2

The difference between the preparation example and the preparation example 1 is that 5kg of bacteriostatic agent finished product consists of the following raw materials by mass: 0.43kg of plant extract, 0.235kg of lysozyme, 0.465kg of pine oil, 0.25kg of benzalkonium bromide, 0.4kg of penetration aid and the balance of water.

Preparation example 3

The difference between the preparation example and the preparation example 1 is that 5kg of bacteriostatic agent finished product consists of the following raw materials by mass: 0.38kg of plant extract, 0.15kg of lysozyme, 0.4kg of pine oil, 0.18kg of benzalkonium bromide, 0.3kg of permeation assistant and the balance of water.

Preparation example 4

The present preparation example differs from preparation example 3 in that the plant extract is portulaca oleracea extract.

Preparation example 5

The difference between the present preparation example and preparation example 3 is that the plant extract is a bamboo leaf extract.

Preparation example 6

This preparation example differs from preparation example 3 in that the permeation aid was soybean lecithin.

Preparation example 7

The difference between the preparation example and the preparation example 3 is that the penetration aid is fatty alcohol-polyoxyethylene ether.

Preparation example 8

The difference between the preparation example and the preparation example 3 is that no plant extract is added in the raw materials of the bacteriostatic agent, and the balance is water.

Preparation example 9

The difference between the preparation example and the preparation example 3 is that lysozyme is not added in the raw materials of the bacteriostatic agent, and the balance is water.

Preparation example 10

The difference between the preparation example and the preparation example 3 is that the raw materials of the bacteriostatic agent are not added with pine oil, and the balance is water.

Preparation example 11

The difference between the preparation example and the preparation example 3 is that benzalkonium bromide is not added in the raw materials of the bacteriostatic agent, and the balance is water.

Examples

Examples 1 to 5 are described below as examples.

Example 1

A liquid soap containing bacteriostatic agents, wherein 50kg of finished liquid soap comprises the following raw materials by mass: 0.4kg of bacteriostatic agent, 0.65kg of nicandra physaloides seed colloidal polysaccharide, 0.15kg of nano activated carbon, 0.025kg of nano silver colloid, 0.3kg of thickening agent, 0.2kg of skin care agent, 0.75kg of detergent, 0.01kg of essence and 47.515kg of other auxiliary agents.

Wherein the bacteriostatic agent is the bacteriostatic agent prepared in the preparation example 3;

the nicandra physaloides seed colloidal polysaccharide is sol obtained by soaking nicandra physaloides seeds in water and then pressurizing and extruding;

the thickening agent is hydroxypropyl methyl cellulose;

the skin care agent is glycerin;

the detergent is a mixture of alkyl glycoside and lauramidopropyl betaine according to the mass ratio of 1;

the pH regulator in other adjuvants is citric acid.

s1, bacteriostatic agent pretreatment: mixing nanometer active carbon and the prepared nicandra physaloides seed colloidal polysaccharide under stirring at 800rpm and 25 deg.C for 20min; keeping the stirring temperature unchanged, then adding the bacteriostatic agent, continuously stirring, adjusting the stirring speed to 600rpm, and stirring for 30min; standing for 1h, adding nano silver colloid, mixing and stirring at 35 ℃ for 30min to obtain a mixture for later use;

s2, preparing a hand sanitizer: and (3) adding the thickening agent, the skin care agent, the detergent and water into the mixture prepared in the step (S1), mixing and stirring at the stirring temperature of 30 ℃ and the stirring speed of 600rpm, adding the pH regulator after stirring for 20min, regulating the pH value of the system to be pH =6.5, and then continuously stirring for 30min to prepare the hand sanitizer.

Examples 1 to 5 in Table 1 differ in the quality of the respective raw materials.

TABLE 1 hand cleanser raw material composition Table

Example 6

This example is different from example 3 in that the bacteriostatic agent is the bacteriostatic agent prepared in preparation example 1.

Example 7

This example is different from example 3 in that the bacteriostatic agent is the bacteriostatic agent prepared in preparation example 2.

Example 8

The difference between this example and example 3 is that the bacteriostatic agent is the bacteriostatic agent prepared in preparation example 4.

Example 9

This example is different from example 3 in that the bacteriostatic agent is the bacteriostatic agent prepared in preparation example 5.

Example 10

This example is different from example 3 in that the bacteriostatic agent is the bacteriostatic agent prepared in preparation example 6.

Example 11

The difference between this example and example 3 is that the bacteriostatic agent is the bacteriostatic agent prepared in preparation example 7.

Example 12

This example differs from example 3 in that the thickener is pectin.

Example 13

This example differs from example 3 in that the skin care agent is lanolin.

Example 14

This example differs from example 3 in that the detergent is an alkyl glycoside.

Example 15

This example differs from example 3 in that the detergent is lauramidopropyl betaine.

Example 16

This example differs from example 3 in that the pH adjuster is malic acid.

Example 17

The difference between the embodiment and the embodiment 3 is that the addition amount of the nicandra physaloides seed colloidal polysaccharide is 1kg, the addition amount of the nano activated carbon is 0.3kg, and the balance is water.

Example 18

The difference between the example and the example 3 is that the addition amount of the nicandra physaloides seed colloidal polysaccharide is 0.65kg, the addition amount of the nano silver colloid is 0.04kg, and the balance is water.

Example 19

The difference between this example and example 3 is that the amount of nano silver colloid added is 0.025kg, the amount of nano activated carbon added is 0.35kg, and the balance is water.

Comparative example

Comparative example 1

This comparative example differs from example 3 in that no nicandra physaloides seed gum polysaccharide is added.

Comparative example 2

This comparative example differs from example 3 in that the nicandra seed mucilaginous polysaccharide is replaced with an equal amount of aloe vera gel.

Comparative example 3

This comparative example differs from example 3 in that no nano-activated carbon was added.

Comparative example 4

This comparative example differs from example 3 in that the nano activated carbon was replaced with an equal amount of montmorillonite powder.

Comparative example 5

This comparative example differs from example 3 in that no nano-silver colloid was added.

Comparative example 6

This comparative example differs from example 3 in that the nano silver colloid was replaced with an equal amount of nano aluminum colloid.

Comparative example 7

The comparative example is different from example 3 in that the addition amount of the bacteriostatic agent is 0.2kg, and the balance is water.

Comparative example 8

The difference between this comparative example and example 3 is that the addition amount of the bacteriostatic agent was 0.8kg, and the balance was water.

Comparative example 9

The comparative example differs from example 3 in that 0.4kg of nicandra physaloides seed glian polysaccharide was added, the balance being water.

Comparative example 10

The comparative example differs from example 3 in that the amount of nicandra physaloides seed glia polysaccharide added is 1.8kg, the balance being water.

Comparative example 11

The difference between the comparative example and the example 3 is that the addition amount of the nano activated carbon is 0.08kg, and the balance is water.

Comparative example 12

The comparative example is different from example 3 in that the amount of nano activated carbon added is 0.5kg, and the balance is water.

Comparative example 13

The comparative example is different from example 3 in that the nano silver colloid is added in an amount of 0.01kg, and the balance is water.

Comparative example 14

The comparative example is different from example 3 in that the nano silver colloid is added in an amount of 0.07kg, and the balance is water.

Comparative example 15

The comparative example differs from example 3 in that the bacteriostatic agent was the bacteriostatic agent prepared in preparation example 8.

Comparative example 16

This comparative example differs from example 3 in that the bacteriostatic agent was the bacteriostatic agent prepared in preparation example 9.

Comparative example 17

The comparative example is different from example 3 in that the bacteriostatic agent is the bacteriostatic agent prepared in preparation example 10.

Comparative example 18

This comparative example differs from example 3 in that the bacteriostatic agent was the bacteriostatic agent prepared in preparation example 11.

Comparative example 19

The difference between the comparative example and the example 3 is that in the hand sanitizer preparation step, a pH regulator is added to adjust the pH value of the system to be pH =5.8.

Comparative example 20

In the antibacterial hand sanitizer in the related art, 50kg of finished hand sanitizer is prepared from the following raw materials in parts by mass: 1kg of amphoteric surfactant, 0.5kg of polyglucoside, 0.8kg of grease ethoxylate, 0.95kg of counter-ion quaternary ammonium salt, 0.2kg of humectant, 0.5kg of thickening agent, 0.03kg of essence, 0.01kg of pH regulator and the balance of water.

Wherein the grease ethoxylate is coconut oil ethoxylate;

the humectant is glycerol;

the thickening agent is carbomer;

the pH regulator is citric acid.

A preparation method of an antibacterial hand sanitizer comprises the following steps:

a1: adding water accounting for 50% of the total mass of the raw materials into a container, heating the water to 60 ℃, adding a thickening agent into the container, and stirring the mixture until the thickening agent is dissolved;

a2: sequentially adding amphoteric surfactant, polyglucoside and lipid ethoxylate into a container, and stirring for 30min; and adding the counter ion quaternary ammonium salt, the humectant and the essence, adjusting the pH to be 6.8 by using a pH regulator, adding the balance of water, and continuously stirring for 30min to obtain the antibacterial hand sanitizer.

Performance test

1. The hand sanitizer prepared in examples 1-19 and comparative examples 1-20 is subjected to bacteriostatic performance test according to the requirements of light industry standard QB/T2738-2012 evaluation method for antibacterial and bacteriostatic effects of daily chemical products.

2. And (3) detecting the lasting antibacterial performance: 390 persons with similar hand shapes are selected, hands of the volunteers are disinfected firstly, and then the same volume of bacterial culture solution is dripped into the same position of the hands of the volunteers, and the bacterial density in each bacterial culture solution is consistent. 390 persons were divided into 39 groups, each group consisting of 10 persons, and 39 groups of volunteers were tested in one-to-one correspondence with the 39 hand cleanser samples of examples 1-19 and comparative examples 1-20.

The detection method comprises the following steps: and (3) the volunteers wash hands by using the corresponding hand sanitizer of the group, the dosage of the hand sanitizer is kept consistent, the hand washing time and the kneading force are kept consistent, the bacterial content of the hands of each volunteer after being washed for 1 time by clear water, 3 times by clear water and 7 times by clear water is respectively detected, the interval of each clear water washing is 10min, the bacterial culture solution with the same volume is dripped at the same position after each clear water washing, and the average bacteriostatic rate of each group of 1 time, 3 times and 7 times by clear water washing is calculated and recorded.

Table 2 performance testing data

As can be seen from table 2, by combining the test results of examples 1 to 5 and comparative example 20, the hand sanitizer prepared by the application has excellent bacteriostatic property and is excellent in bacteriostatic durability, wherein example 3 is a preferred example, and the bacteriostatic property and bacteriostatic durability are better.

The test results of the examples 3, 17-19 and the comparative examples 1-6 show that the nicandra physaloides seed colloidal polysaccharide, the nano activated carbon and the nano silver colloid all have good effects of improving the antibacterial persistence of the hand sanitizer, and have synergistic effects, so that the prepared hand sanitizer has better antibacterial persistence by matching the three components.

By combining the test results of example 3 and comparative examples 15-18, the plant extract, lysozyme, pine oil and benzalkonium bromide can improve the bacteriostatic effect of the hand sanitizer, and the prepared hand sanitizer has the best bacteriostatic performance by combining the four components. Meanwhile, the pine oil has a positive effect on improving the antibacterial persistence of the hand sanitizer.

The present embodiment is only for explaining the present application, and it is not limited to the present application, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present application.

Claims

1. A liquid soap containing bacteriostatic agent is characterized in that: the hand sanitizer comprises the following raw materials in percentage by mass as 100 percent: 0.8-2% of bacteriostatic agent, 1.3-2.6% of nicandra physaloides seed colloidal polysaccharide, 0.3-0.7% of nano activated carbon, 0.05-0.08% of nano silver colloid, 0.6-1.3% of thickening agent, 0.4-0.9% of skin care agent, 1.5-2.5% of detergent, 0.02-0.05% of essence and the balance of other auxiliary agents; the bacteriostatic agent consists of the following raw materials in percentage by mass of 100 percent: 6.9 to 8.6 percent of plant extract, 2 to 4.7 percent of lysozyme, 7.5 to 9.3 percent of pine oil, 2.8 to 5 percent of benzalkonium bromide, 5 to 8 percent of penetration assistant and the balance of water; the plant extract is a portulaca oleracea extract, a bamboo leaf extract or a mixture consisting of the portulaca oleracea extract, the bamboo leaf extract and the artemisia argyi extract according to a mass ratio of 2; the penetration auxiliary agent is one or two of soybean lecithin and fatty alcohol-polyoxyethylene ether; the other auxiliary agents comprise a pH regulator and water, wherein the pH regulator comprises one or more of tartaric acid, citric acid and malic acid.

2. The hand sanitizer containing the bacteriostatic agent as claimed in claim 1, wherein: the thickening agent comprises one or two of hydroxypropyl methyl cellulose and pectin.

3. The hand sanitizer containing bacteriostatic agent of claim 1, wherein: the skin care agent comprises one or two of glycerin and lanolin.

4. The hand sanitizer containing bacteriostatic agent of claim 1, wherein: the detergent comprises one or more of cocamidopropyl betaine, alkyl glycoside, lauramidopropyl betaine.

5. The method for preparing a hand sanitizer containing a bacteriostatic agent as defined in claim 1, which is characterized in that: the preparation method of the hand sanitizer comprises the following steps:

pretreating a bacteriostatic agent: mixing and stirring nano activated carbon and the prepared nicandra physaloides seed colloidal polysaccharide, then adding the prepared bacteriostatic agent, continuing stirring, standing, adding the nano silver colloid, and mixing and stirring to prepare a mixture for later use;

6. The method of preparing a liquid soap containing a bacteriostatic agent according to claim 5, wherein the bacteriostatic agent comprises the following components: in the step of preparing the hand sanitizer, the pH value of the system is adjusted to 6.5-6.8.