CN110100839A - A kind of bacteriostatic agent combination and preparation method thereof and the application in antibacterial tableware washing detergent liquid - Google Patents
A kind of bacteriostatic agent combination and preparation method thereof and the application in antibacterial tableware washing detergent liquid Download PDFInfo
- Publication number
- CN110100839A CN110100839A CN201910437693.3A CN201910437693A CN110100839A CN 110100839 A CN110100839 A CN 110100839A CN 201910437693 A CN201910437693 A CN 201910437693A CN 110100839 A CN110100839 A CN 110100839A
- Authority
- CN
- China
- Prior art keywords
- quantum dot
- graphene quantum
- chain alkyl
- long
- antibacterial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/10—Apiaceae or Umbelliferae [Carrot family], e.g. parsley, caraway, dill, lovage, fennel or snakebed
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/34—Rosaceae [Rose family], e.g. strawberry, hawthorn, plum, cherry, peach, apricot or almond
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/88—Ampholytes; Electroneutral compounds
- C11D1/94—Mixtures with anionic, cationic or non-ionic compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/02—Inorganic compounds ; Elemental compounds
- C11D3/12—Water-insoluble compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2075—Carboxylic acids-salts thereof
- C11D3/2086—Hydroxy carboxylic acids-salts thereof
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/22—Carbohydrates or derivatives thereof
- C11D3/222—Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid or cyclodextrin
- C11D3/225—Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid or cyclodextrin etherified, e.g. CMC
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/26—Organic compounds containing nitrogen
- C11D3/33—Amino carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/37—Polymers
- C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C11D3/3707—Polyethers, e.g. polyalkyleneoxides
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/382—Vegetable products, e.g. soya meal, wood flour, sawdust
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/02—Anionic compounds
- C11D1/04—Carboxylic acids or salts thereof
- C11D1/10—Amino carboxylic acids; Imino carboxylic acids; Fatty acid condensates thereof
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/662—Carbohydrates or derivatives
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/88—Ampholytes; Electroneutral compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/88—Ampholytes; Electroneutral compounds
- C11D1/90—Betaines
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/88—Ampholytes; Electroneutral compounds
- C11D1/92—Sulfobetaines ; Sulfitobetaines
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dentistry (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Agronomy & Crop Science (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Emergency Medicine (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Pest Control & Pesticides (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Detergent Compositions (AREA)
Abstract
The invention belongs to daily use chemicals articles for washing technical fields, and in particular to a kind of bacteriostatic agent combination and preparation method thereof and the application in antibacterial tableware washing detergent liquid.The bacteriostatic agent group is combined into long-chain alkyl lycine graphene quantum dot and natural plant extracts, mass ratio 1:8 ~ 1:1 of the long-chain alkyl lycine graphene quantum dot and natural plant extracts；Wherein, the natural plant extracts are one of A meter Qin, cistus incanus and Herba speranskiae tuberculatae extract or a variety of mixtures.This method compounds natural plant antibacterial agent with nano anti-biotic material graphene quantum dot (GQDs), it not only can use the efficient quick-acting of GQDs antimicrobial nano material, it using the feature of environmental protection of natural plants antimicrobial component, complexity, broad spectrum antibacterial and can also be not easy to make the advantages that bacterial resistance occurred, to reach collaboration bacteriostasis, the Compound Resisting microbial inoculum of novel high-efficiency environment friendly is developed.
Description
Technical field
The invention belongs to daily use chemicals articles for washing technical fields, and in particular to a kind of bacteriostatic agent combination and preparation method thereof and
Application in antibacterial tableware washing detergent liquid.
Background technique
With the development of society, the gradually enhancing of people's ecological, environmental protective consciousness, people are more next to the quality requirement of antibacterial agent
It is higher.Chemical synthesis antibacterial agent makes microorganism develop drug resistance etc. not met and work as due to difficult to degrade, high residue in the environment, easily
The preceding market demand.Therefore, it under the precondition for ensuring effectively to sterilize, reduces the application of chemical synthesis antibacterial agent and seeks
Novel green antibacterial agent has become current research hotspot.
Carbon nanomaterial based on graphene, environmentally friendly, cytotoxicity is low, good biocompatibility, is widely used
In medicine and life science.Graphene quantum dot (GQDs) is the newcomer of graphene family, is a kind of with graphene-structured
Quanta point material, size is in 10 nm or so.Due to its minimum size, high specific surface area, good water-soluble, adjustable
Humorous performance, the research and application of GQDs have been to be concerned by more and more people.Different molecules and functional group pair can be passed through
GQDs is functionalized to be modified with surface, to meet the application demands such as bio-imaging, drug conveying, sensing and antibacterial.However,
GQDs is since the presoma diversity in synthetic method is high, and the surface charge and functional character of the GODs of distinct methods preparation is not
Together, so that but also synthesized GQDs shows different dispersion performance and anti-microbial property.Therefore, developing one kind has
The graphene quantum dot nano material of superior dispersibility and anti-microbial property has the very big market demand.
Effective antibacterial and sterilization component in plant-source antibacterial agent is extracted out of natural plants body, is had inexpensive, low
The advantages that poison, easily decomposition and environmental sound.Since the antibacterial activity of single restraining and sterilizing bacteria ingredient is poor, antimicrobial spectrum is relatively narrow and
Long-time service is also easy to produce the defects of drug resistance, therefore compounds to a variety of antibacterial plant ingredients, enhances its antibacterial efficacy, expands it
Broad spectrum antibacterial is very important.
Summary of the invention
In view of the deficiencies of the prior art, the present invention provides a kind of bacteriostatic agent combination and preparation method thereof and in antibacterial tableware washing detergent liquid
In application, natural plant antibacterial agent compounds with nano anti-biotic material graphene quantum dot (GQDs), not only may be used by this method
With using the efficient quick-acting of GQDs antimicrobial nano material, can also using the feature of environmental protection of natural plants antimicrobial component, complexity,
It broad spectrum antibacterial and is not easy to make the advantages that bacterial resistance occurred, to reach collaboration bacteriostasis, develop new and effective
The Compound Resisting microbial inoculum of environmental protection.
In order to achieve the above object, the present invention is achieved by the following technical programs:
The first purpose of the invention is to provide a kind of combination of bacteriostatic agent, the bacteriostatic agent group is combined into long-chain alkyl lycine stone
Black alkene quantum dot and natural plant extracts, the long-chain alkyl lycine@graphene quantum dot and natural plant extracts
Mass ratio 1:8 ~ 1:1；Wherein, the natural plant extracts are one in A meter Qin, cistus incanus and Herba speranskiae tuberculatae extract
Kind or a variety of mixtures.
As a preferred solution of the present invention, the long-chain alkyl lycine@graphene quantum dot the preparation method is as follows: with
Citric acid is that carbon source pyrolysismethod in ammonium hydroxide prepares amino functional graphene quantum dot；It is reacted again by carboxyl amine, by long-chain
Alkyl betaine is supported on amino functional graphene quantum dot surface, and long-chain alkyl lycine@graphene quantum dot is made.
As a preferred solution of the present invention, the partial size of the long-chain alkyl lycine@graphene quantum dot is 5 ~ 15 nm.
A second object of the present invention is to provide a kind of preparation methods of bacteriostatic agent combination, comprising the following steps:
(1) preparation of amino functional graphene quantum dot:
Citric acid is dissolved in secondary distilled water and is added ammonium hydroxide, after mixing, mixture is transferred in polytetrafluoroethylene (PTFE)
In the autoclave of lining, 4 ~ 8 h of insulation reaction and it is cooled to room temperature at 100 ~ 200 DEG C；It is filtered to remove insoluble fragment；It will obtain
Clarified solution dialysis, freeze-drying obtain solid powder, as amino functional graphene quantum dot；
(2) preparation of long-chain alkyl lycine@graphene quantum dot nano antibacterial agent:
Long-chain alkyl lycine is sub- in 1- (3- dimethylamino-propyl) -3- ethyl-carbodiimide hydrochloride and N- hydroxysuccinimidyl acyl
It is activated in 2- (N- morpholine) ethanesulfonic acid buffer of amine, wherein the concentration of 2- (N- morpholine) ethanesulfonic acid buffer is 0.1
mol·L-1, pH value 6.0, after activation, the phosphate buffer solution of addition amino functional graphene quantum dot in mixed liquor
Reaction, dialysis, freeze-drying obtain long-chain alkyl lycine@graphene quantum dot, wherein the long-chain alkyl lycine is N-
Chain alkyl carboxylic acid type glycine betaine, molecular formula are as follows: CH3(CH2)nN+(CH3)2CH2COO-, n=11 ~ 17 in formula；
(3) preparation of bacteriostatic agent combination:
By long-chain alkyl lycine@graphene quantum dot obtained by step (2) and natural plant extracts according to mass ratio 1:8 ~ 1:1
It prepares, obtains compound；As bacteriostatic agent combines.
Wherein, the natural plant extracts are one of A meter Qin, cistus incanus and Herba speranskiae tuberculatae extract or more
Kind mixture.
Specifically, the preparation step of the amino functional graphene quantum dot is as follows:
Citric acid is dissolved in secondary distilled water, is added ammonium hydroxide (28wt% aqueous solution), after mixing, mixture is transferred to
In the autoclave of polytetrafluoroethyllining lining, 4 ~ 8 h of insulation reaction at 100 ~ 200 DEG C.After being cooled to room temperature, with 0.22 μm
Water system miillpore filter filtering, removes insoluble fragment.By obtained clarified solution through bag filter that molecular cut off is 1 KDa in going
Dialyse 48 h in ionized water, then freeze-dried to obtain solid powder, as amino functional graphene quantum dot.
The preparation of the long-chain alkyl lycine@graphene quantum dot nano antibacterial agent:
By long-chain alkyl lycine (BS) in 1- (3- dimethylamino-propyl) -3- ethyl-carbodiimide hydrochloride (EDCHCl) and
2- (N- morpholine) ethanesulfonic acid buffer (0.1 molL of n-hydroxysuccinimide (NHS)-1, pH=6.0) and 0.5 h of middle activation.
Wherein, the ratio between amount of substance of each raw material is BS:EDCHCl:NHS=1:4:4.After activation, amino function is added in mixed liquor
Can graphite alkene quantum dot phosphate buffer solution, react 12 h, through molecular cut off be 1 KDa bag filter in deionization
Dialyse 24 h in water, then freeze-dried to obtain long-chain alkyl lycine@graphene quantum dot nano antibacterial agent, wherein long-chain
Alkyl betaine is N- chain alkyl carboxylic acid type glycine betaine, molecular formula are as follows: CH3(CH2)nN+(CH3)2CH2COO-, n=11 in formula ~
17。
The A meter Qin extract the preparation method comprises the following steps: the seed of A meter Qin (Ammi Visnaga) and aerial part are used
After pulverizer crushes, 30-50 mesh powder is collected, powder and 4%NaCl aqueous solution mass ratio 1:6-12 is taken, uses Clevenger type
Laser heating flows back 6 hours to there is no until oil droplet drippage to volatile oil determination apparatus under normal pressure, collects upper layer essential oil, nothing is added
It is filtered after aqueous sodium persulfate is dry, obtains A meter Qin extract.
The cistus incanus extracts the preparation method comprises the following steps: by the cauline leaf of cistus incanus (Cistus Incanus)
After being crushed with pulverizer, 30-50 mesh powder is collected.Take powder and water quality ratio 1:4-6,100 DEG C immersion 5-10 minutes, filtering
Filtrate, the active carbon decoloring of filtrate are obtained, the filtrate after decoloration removes solvent and obtains cistus incanus extracts.
The Herba speranskiae tuberculatae extract the preparation method comprises the following steps: lopseed (Phryma leptostachya L.) is used pulverizer
After crushing, 30-50 mesh powder is collected.Take powder and 60wt% ethyl alcohol mass ratio 1:8-12,75 DEG C extraction 2-4 hours, filter
To filtrate, the active carbon decoloring of filtrate, the filtrate after decoloration removes solvent and obtains Herba speranskiae tuberculatae extract.
Third object of the present invention is to provide a kind of antibacterial tableware washing detergent liquids of bacteriostatic agent combination, and the antibacterial tableware washing detergent liquid is under
The group for stating mass fraction is grouped as:
| Alkyl polyglycoside | 0~30% |
| Amino acid type surfactant | 0~20% |
| Amphoteric surfactant | 0~10% |
| Thickener | 0~3% |
| Citric acid | 0-2% |
| Chelating agent | 0.05~0.1% |
| Bacteriostatic agent combination | 1.5~5.0% |
| Water | Surplus. |
As a preferred solution of the present invention, the alkyl polyglycoside is octyl-Plantacare 818, cocoyl glucoside or lauryl
Glucoside.
As a preferred solution of the present invention, the amino acid type surfactant is lauroyl glutamate, cocounut oil acyl
It is glutamate, Hamposyl L salt, one or more in cocoyl sarcosine salt.
As a preferred solution of the present invention, the thickener be cellulose thickener, guar gum and its derivative species,
It is one or more in the double stearates of PEG-120 methyl dioleate, Macrogol 6000.
As a preferred solution of the present invention, the chelating agent is EDTA-2Na.
Fourth object of the present invention is that antibacterial tableware washing detergent liquid of the invention can be applied to meal wash field.Due to chain alkyl sweet tea
The collaboration bacteriostasis of dish alkali@graphene quantum dot and natural plant extracts, bacteriostatic activity greatly improve, effectively antibacterial
While, dirt can be removed, and play the role of removing odors, realize a step and complete decontamination, antibacterial and taste removal purpose.
The present invention is coated on GQDs nanoparticle surface using long-chain alkyl lycine, constructs long-chain alkyl lycine@stone
Black alkene quantum dot nano antibacterial agent, shows the antibacterial activity of enhancing, and minimal inhibitory concentration value is substantially less than free chain alkyl
Glycine betaine；Alkyl betaine molecule covalent is bonded to the surface GQDs, makes the surface GQDs that there is apparent local positive charge density
With hydrophobic chain number, to greatly improve its anti-microbial property.
Contain non-terpene ester, terpene and oxygen-containing terpenoid in A meter Qin (Ammi Visnaga), has stronger anti-
Bacterial activity, moreover it is possible to enhance vascular dynamics.Contain labdane type diterpene chemical combination in cistus incanus (Cistus Incanus)
Object can be used as anti-inflammatory agent treatment local skin inflammation.Effect ingredient wood in lopseed (Phryma leptostachya L.)
Rouge element substance has anti-inflammatory, antibacterial, anti-oxidant, antiallergy and antitumor and other effects.
Compared with prior art, the invention has the following advantages:
(1) the method for the present invention raw material is easy to get, simple process: the present invention is using citric acid cheap and easy to get as carbon source, preferably " under
On and " one-step synthesis method amino functional graphene quantum dot.It is reacted by simple carboxyl amine, by alkyl betaine and ammonia
The graphene quantum dot of base functionalization is coupled, and obtains long-chain alkyl lycine@graphene quantum dot antibacterial agent, and average grain diameter is
5~15 nm.Preparation method is simple and efficient, is at low cost, it can be achieved that industrialized production.
(2) antibacterial agent combination product excellent antibacterial performance obtained by the method for the present invention:
(3) the antibacterial tableware washing detergent liquid of green of the method for the present invention preparation it is antibacterial it is high-efficient, nontoxic, non-stimulated, environmental-friendly, can biology
Degradation and with rear noresidue, can be used for the cleaning of tableware.
Specific embodiment
Below by specific embodiment, invention is further described in detail.But those skilled in the art will manage
Solution, the following example is merely to illustrate the present invention, and should not be taken as limiting the scope of the invention.Specific skill is not specified in embodiment
Art or condition person, described technology or conditions carry out to specifications according to the literature in the art.Agents useful for same or instrument
Production firm person is not specified, being can be with conventional products that are commercially available.
In specific embodiment 4-10, long-chain alkyl lycine graphene quantum dot is indicated with A, A meter Qin, graywacke rose
Common vetch and Herba speranskiae tuberculatae extract group share B expression.Then complex antimicrobials 1 represent A:B=1:8 in following embodiment;Complex antimicrobials 2
Represent A:B=1:4；Complex antimicrobials 3 represent A:B=1:2；Complex antimicrobials 3 represent A:B=1:1.
Embodiment 1
A kind of preparation method of bacteriostatic agent combination, comprising the following steps:
(1) preparation of amino functional graphene quantum dot:
Citric acid is dissolved in secondary distilled water, is added ammonium hydroxide (28wt% aqueous solution), after mixing, mixture is transferred to
In the autoclave of polytetrafluoroethyllining lining, 4 ~ 8 h of insulation reaction at 100 ~ 200 DEG C.After being cooled to room temperature, with 0.22 μm
Water system miillpore filter filtering, removes insoluble fragment.By obtained clarified solution through bag filter that molecular cut off is 1 KDa in going
Dialyse 48 h in ionized water, then freeze-dried to obtain solid powder, as amino functional graphene quantum dot；
(2) preparation of long-chain alkyl lycine@graphene quantum dot nano antibacterial agent:
By long-chain alkyl lycine (BS) in 1- (3- dimethylamino-propyl) -3- ethyl-carbodiimide hydrochloride (EDCHCl) and
2- (N- morpholine) ethanesulfonic acid buffer (0.1 molL of n-hydroxysuccinimide (NHS)-1, pH=6.0) and 0.5 h of middle activation.
Wherein, the ratio between amount of substance of each raw material is BS:EDCHCl:NHS=1:4:4.After activation, amino function is added in mixed liquor
Can graphite alkene quantum dot phosphate buffer solution, react 12 h, through molecular cut off be 1 KDa bag filter in deionization
Dialyse 24 h in water, then freeze-dried to obtain long-chain alkyl lycine@graphene quantum dot nano antibacterial agent, wherein long-chain
Alkyl betaine is N- chain alkyl carboxylic acid type glycine betaine, molecular formula are as follows: CH3(CH2)nN+(CH3)2CH2COO-, n=11 in formula ~
17。
(3) preparation of bacteriostatic agent combination:
Long-chain alkyl lycine@graphene quantum dot obtained by step (2) and natural plant extracts are matched according to mass ratio 1:8
System, obtains compound；As bacteriostatic agent combines.
Wherein, the natural plant extracts be A meter Qin, the A meter Qin extract the preparation method comprises the following steps: by A meter Qin
After the seed and aerial part of (Ammi Visnaga) are crushed with pulverizer, 30-50 mesh powder is collected, powder and 4%NaCl water are taken
Solution quality ratio 1:6-12, using Clevenger type volatile oil determination apparatus under normal pressure laser heating flow back 6 hours to there is no
Until oil droplet drips, upper layer essential oil is collected, is filtered after anhydrous sodium sulfate drying is added, obtains A meter Qin extract.
Embodiment 2
A kind of preparation method of bacteriostatic agent combination, comprising the following steps:
(1) preparation of amino functional graphene quantum dot:
Citric acid is dissolved in secondary distilled water, is added ammonium hydroxide (28wt% aqueous solution), after mixing, mixture is transferred to
In the autoclave of polytetrafluoroethyllining lining, 4 ~ 8 h of insulation reaction at 100 ~ 200 DEG C.After being cooled to room temperature, with 0.22 μm
Water system miillpore filter filtering, removes insoluble fragment.By obtained clarified solution through bag filter that molecular cut off is 1 KDa in going
Dialyse 48 h in ionized water, then freeze-dried to obtain solid powder, as amino functional graphene quantum dot；
(2) preparation of long-chain alkyl lycine@graphene quantum dot nano antibacterial agent:
By long-chain alkyl lycine (BS) in 1- (3- dimethylamino-propyl) -3- ethyl-carbodiimide hydrochloride (EDCHCl) and
2- (N- morpholine) ethanesulfonic acid buffer (0.1 molL of n-hydroxysuccinimide (NHS)-1, pH=6.0) and 0.5 h of middle activation.
Wherein, the ratio between amount of substance of each raw material is BS:EDCHCl:NHS=1:4:4.After activation, amino function is added in mixed liquor
Can graphite alkene quantum dot phosphate buffer solution, react 12 h, through molecular cut off be 1 KDa bag filter in deionization
Dialyse 24 h in water, then freeze-dried to obtain long-chain alkyl lycine@graphene quantum dot nano antibacterial agent, wherein long-chain
Alkyl betaine is N- chain alkyl carboxylic acid type glycine betaine, molecular formula are as follows: CH3(CH2)nN+(CH3)2CH2COO-, n=11 in formula ~
17。
(3) preparation of bacteriostatic agent combination:
Long-chain alkyl lycine@graphene quantum dot obtained by step (2) and natural plant extracts are matched according to mass ratio 1:2
System, obtains compound；As bacteriostatic agent combines.
Wherein, the natural plant extracts are cistus incanus extracts；The preparation of the cistus incanus extracts
Method are as follows: after crushing the cauline leaf of cistus incanus (Cistus Incanus) with pulverizer, collect 30-50 mesh powder.Take powder
End and water quality ratio 1:4-6,100 DEG C immersions 5-10 minute, be obtained by filtration filtrate, filtrate use activity carbon decoloring, after decoloration
Filtrate removes solvent and obtains cistus incanus extracts.
Embodiment 3
A kind of preparation method of bacteriostatic agent combination, comprising the following steps:
(1) preparation of amino functional graphene quantum dot:
Citric acid is dissolved in secondary distilled water, is added ammonium hydroxide (28wt% aqueous solution), after mixing, mixture is transferred to
In the autoclave of polytetrafluoroethyllining lining, 4 ~ 8 h of insulation reaction at 100 ~ 200 DEG C.After being cooled to room temperature, with 0.22 μm
Water system miillpore filter filtering, removes insoluble fragment.By obtained clarified solution through bag filter that molecular cut off is 1 KDa in going
Dialyse 48 h in ionized water, then freeze-dried to obtain solid powder, as amino functional graphene quantum dot；
(2) preparation of long-chain alkyl lycine@graphene quantum dot nano antibacterial agent:
By long-chain alkyl lycine (BS) in 1- (3- dimethylamino-propyl) -3- ethyl-carbodiimide hydrochloride (EDCHCl) and
2- (N- morpholine) ethanesulfonic acid buffer (0.1 molL of n-hydroxysuccinimide (NHS)-1, pH=6.0) and 0.5 h of middle activation.
Wherein, the ratio between amount of substance of each raw material is BS:EDCHCl:NHS=1:4:4.After activation, amino function is added in mixed liquor
Can graphite alkene quantum dot phosphate buffer solution, react 12 h, through molecular cut off be 1 KDa bag filter in deionization
Dialyse 24 h in water, then freeze-dried to obtain long-chain alkyl lycine@graphene quantum dot nano antibacterial agent, wherein long-chain
Alkyl betaine is N- chain alkyl carboxylic acid type glycine betaine, molecular formula are as follows: CH3(CH2)nN+(CH3)2CH2COO-, n=11 in formula ~
17。
(3) preparation of bacteriostatic agent combination:
Long-chain alkyl lycine@graphene quantum dot obtained by step (2) and natural plant extracts are matched according to mass ratio 1:4
System, obtains compound；As bacteriostatic agent combines.
Wherein, the natural plant extracts are Herba speranskiae tuberculatae extract；The Herba speranskiae tuberculatae extract the preparation method comprises the following steps: will
After lopseed (Phryma leptostachya L.) is crushed with pulverizer, 30-50 mesh powder is collected.Take powder and 60wt% second
Alcohol mass ratio 1:8-12,75 DEG C extraction 2-4 hours, be obtained by filtration filtrate, filtrate with active carbon decoloring, remove by the filtrate after decoloration
Solvent is gone to obtain Herba speranskiae tuberculatae extract.
Embodiment 4
A kind of antibacterial tableware washing detergent liquid of bacteriostatic agent combination, the antibacterial tableware washing detergent liquid consist of the following components in percentage by mass:
| Serial number | Material name | Percentage composition |
| 1 | Water | Surplus |
| 2 | Lauryl glucoside | 18% |
| 3 | Cocoamidopropyl betaine | 5% |
| 4 | Lauroyl glutamate potassium | 20% |
| 5 | The double stearates of Macrogol 6000 | 2% |
| 6 | EDTA-2Na | 0.05% |
| 7 | Citric acid | Appropriate PH5.5-6.5 |
| 8 | Complex antimicrobials 2 | 3% |
The above-mentioned antibacterial tableware washing detergent liquid of green the preparation method is as follows:
1,1,2,3,4 raw material is successively weighed and stirring and dissolving is uniform, temperature is maintained at 70-80 DEG C；
2,5 are added, stirring dissolves it sufficiently completely, and stirring starts to cool down after ten minutes；
3,6,7 are added, adjusts pH value between 5.5-6.5
4,8 are added when temperature drops to 45 DEG C or less, discharged after stirring.
Embodiment 5
A kind of antibacterial tableware washing detergent liquid of bacteriostatic agent combination, the antibacterial tableware washing detergent liquid consist of the following components in percentage by mass:
| Serial number | Material name | Percentage composition |
| 1 | Water | Surplus |
| 2 | Lauryl glucoside | 18% |
| 3 | Cocoamidopropyl betaine | 5% |
| 4 | Lauroyl glutamate potassium | 20% |
| 5 | The double stearates of Macrogol 6000 | 2 |
| 6 | EDTA-2Na | 0.05% |
| 7 | Citric acid | Appropriate PH5.5-6.5 |
| 8 | Complex antimicrobials 2 | 1.5% |
Embodiment 6
A kind of antibacterial tableware washing detergent liquid of bacteriostatic agent combination, the antibacterial tableware washing detergent liquid consist of the following components in percentage by mass:
| Serial number | Material name | Percentage composition |
| 1 | Water | Surplus |
| 2 | Lauryl glucoside | 18% |
| 3 | Cocoamidopropyl betaine | 5% |
| 4 | Lauroyl glutamate potassium | 20% |
| 5 | The double stearates of Macrogol 6000 | 2 |
| 6 | EDTA-2Na | 0.05% |
| 7 | Citric acid | Appropriate PH5.5-6.5 |
| 8 | Complex antimicrobials 2 | 4.5% |
Embodiment 7
A kind of antibacterial tableware washing detergent liquid of bacteriostatic agent combination, the antibacterial tableware washing detergent liquid consist of the following components in percentage by mass:
| Serial number | Material name | Percentage composition |
| 1 | Water | Surplus |
| 2 | Sodium lauroyl glutamate | 12% |
| 3 | Cocoyl glucoside | 20% |
| 4 | Cocamidopropyl propyl amide hydroxy sulfo lycine | 10% |
| 5 | PEG-120 methyl dioleate | 1% |
| 6 | EDTA-2Na | 0.1% |
| 7 | Citric acid | Appropriate PH5.5-6.5 |
| 8 | Complex antimicrobials 1 | 3% |
Embodiment 8
A kind of antibacterial tableware washing detergent liquid of bacteriostatic agent combination, the antibacterial tableware washing detergent liquid consist of the following components in percentage by mass:
| Serial number | Material name | Percentage composition |
| 1 | Water | Surplus |
| 2 | Lauroyl glutamate potassium | 30% |
| 3 | Lauroyl both sexes base sodium acetate | 15% |
| 4 | Hydroxypropyl methyl cellulose | 1% |
| 5 | EDTA-2Na | 0.1% |
| 6 | Citric acid | Appropriate PH5.5-6.5 |
| 7 | Complex antimicrobials 3 | 2% |
Embodiment 9
A kind of antibacterial tableware washing detergent liquid of bacteriostatic agent combination, the antibacterial tableware washing detergent liquid consist of the following components in percentage by mass:
| Serial number | Material name | Percentage composition |
| 1 | Water | Surplus |
| 2 | Lauryl glucoside | 20% |
| 3 | Cocamidopropyl propyl amide hydroxy sulfo lycine | 15% |
| 4 | PEG-120 methyl dioleate | 1% |
| 5 | EDTA-2Na | 0.05% |
| 6 | Citric acid | Appropriate PH5.5-6.5 |
| 7 | Complex antimicrobials 4 | 1.5% |
Comparative example 1
A kind of antibacterial tableware washing detergent liquid of bacteriostatic agent combination, the antibacterial tableware washing detergent liquid consist of the following components in percentage by mass:
| Serial number | Material name | Percentage composition |
| 1 | Water | Surplus |
| 2 | Lauroyl glutamate potassium | 20% |
| 3 | Lauryl glucoside | 18% |
| 4 | Cocoamidopropyl betaine | 5% |
| 5 | The double stearates of Macrogol 6000 | 0.6% |
| 6 | EDTA-2Na | 0.05% |
| 7 | Citric acid | Appropriate PH5.5-6.5 |
| 8 | Shredding | 0.06% |
Comparative example 2
A kind of antibacterial tableware washing detergent liquid of bacteriostatic agent combination, the antibacterial tableware washing detergent liquid consist of the following components in percentage by mass:
| Serial number | Material name | Percentage composition |
| 1 | Water | Surplus |
| 2 | Lauroyl glutamate potassium | 20% |
| 3 | Lauryl glucoside | 18% |
| 4 | Cocoamidopropyl betaine | 5% |
| 5 | The double stearates of Macrogol 6000 | 0.6% |
| 6 | EDTA-2Na | 0.05% |
| 7 | Citric acid | Appropriate PH5.5-6.5 |
| 8 | A | 0.4% |
Comparative example 3
A kind of antibacterial tableware washing detergent liquid of bacteriostatic agent combination, the antibacterial tableware washing detergent liquid consist of the following components in percentage by mass:
| Serial number | Material name | Percentage composition |
| 1 | Water | Surplus |
| 2 | Lauroyl glutamate potassium | 20% |
| 3 | Lauryl glucoside | 18% |
| 4 | Cocoamidopropyl betaine | 5% |
| 5 | The double stearates of Macrogol 6000 | 0.6% |
| 6 | EDTA-2Na | 0.05% |
| 7 | Citric acid | Appropriate PH5.5-6.5 |
| 8 | B | 1.6% |
Comparative example 4
A kind of antibacterial tableware washing detergent liquid of bacteriostatic agent combination, the antibacterial tableware washing detergent liquid consist of the following components in percentage by mass:
| Serial number | Material name | Percentage composition |
| 1 | Water | Surplus |
| 2 | Lauroyl glutamate potassium | 20% |
| 3 | Lauryl glucoside | 18% |
| 4 | Cocoamidopropyl betaine | 5% |
| 5 | The double stearates of Macrogol 6000 | 0.6% |
| 6 | EDTA-2Na | 0.05% |
| 7 | Citric acid | Appropriate PH5.5-6.5 |
| 8 | Nano silver ion antibiotic agent | 0.4% |
The measurement of dishwashing number:
Artificial dishwashing number test: by made embodiment 4,7,8,9 according to manual dishwashing with detergent national standard GB9985-2000's
Artificial dishwashing number test method carries out dishwashing test.The results are shown in Table 1.
The corresponding dishwashing number of each embodiment of table 1
| Embodiment | 4 | 7 | 8 | 9 |
| Dishwashing number/ | 3.5 | 3.5 | 3 | 2.5 |
From test result as can be seen that each embodiment dishwashing number is all larger than 2.5 plates of national standard.
Biocidal property test:
The above is only preferred embodiments of the present invention, is not intended to limit the scope of the present invention, therefore all
It is any trickle amendment, equivalent variations and modification made to the above embodiment according to the technical essence of the invention, belongs to this
In the range of inventive technique scheme.
Claims (10)
1. a kind of combination of bacteriostatic agent, which is characterized in that the bacteriostatic agent group be combined into long-chain alkyl lycine graphene quantum dot and
Natural plant extracts, mass ratio 1:8~1 of the long-chain alkyl lycine@graphene quantum dot and natural plant extracts:
1；Wherein, the natural plant extracts are one of A meter Qin, cistus incanus and Herba speranskiae tuberculatae extract or a variety of mixed
Close object.
2. a kind of bacteriostatic agent combination according to claim 1, which is characterized in that the long-chain alkyl lycine@graphene
Quantum dot the preparation method is as follows: the pyrolysismethod in ammonium hydroxide prepares amino functional graphene quantum dot using citric acid as carbon source；
Again by carboxyl-amine reaction, long-chain alkyl lycine is supported on amino functional graphene quantum dot surface, long alkane is made
Base glycine betaine@graphene quantum dot.
3. a kind of bacteriostatic agent combination according to claim 2, which is characterized in that the long-chain alkyl lycine@graphene
The partial size of quantum dot is 5~15nm.
4. a kind of preparation method of bacteriostatic agent combination as claimed in claim 3, which comprises the following steps:
(1) preparation of amino functional graphene quantum dot:
Citric acid is dissolved in secondary distilled water and is added ammonium hydroxide, after mixing, mixture is transferred in polytetrafluoroethylene (PTFE)
In the autoclave of lining, 4~8h of insulation reaction and it is cooled to room temperature at 100~200 DEG C；It is filtered to remove insoluble fragment；Will
To clarified solution dialysis, freeze-drying obtain solid powder, as amino functional graphene quantum dot；
(2) preparation of long-chain alkyl lycine@graphene quantum dot nano antibacterial agent:
Long-chain alkyl lycine is sub- in 1- (3- dimethylamino-propyl) -3- ethyl-carbodiimide hydrochloride and N- hydroxysuccinimidyl acyl
It is activated in 2- (N- morpholine) ethanesulfonic acid buffer of amine, wherein the concentration of 2- (N- morpholine) ethanesulfonic acid buffer is
0.1mol·L-1, pH value 6.0, after activation, the phosphate-buffered of addition amino functional graphene quantum dot in mixed liquor
Solution reaction, dialysis, freeze-drying obtain long-chain alkyl lycine@graphene quantum dot, wherein the long-chain alkyl lycine
For N- chain alkyl carboxylic acid type glycine betaine, molecular formula are as follows: CH3(CH2)nN+(CH3)2CH2COO-, n=11~17 in formula；
(3) preparation of bacteriostatic agent combination:
By long-chain alkyl lycine@graphene quantum dot obtained by step (2) and natural plant extracts according to mass ratio 1:8~1:
1 prepares, and obtains compound；As bacteriostatic agent combines, wherein the natural plant extracts are A meter Qin, cistus incanus
With one of Herba speranskiae tuberculatae extract or a variety of mixtures.
5. the antibacterial tableware washing detergent liquid based on a kind of combination of bacteriostatic agent described in claim 1-3 any claim, which is characterized in that
The antibacterial tableware washing detergent liquid consists of the following components in percentage by mass:
6. antibacterial tableware washing detergent liquid according to claim 5, which is characterized in that the alkyl polyglycoside is octyl-decyl glucose
Glycosides, cocoyl glucoside or lauryl glucoside.
7. antibacterial tableware washing detergent liquid according to claim 5, which is characterized in that the amino acid type surfactant is laurel
It is acyl glutamate, cocounut oil acyl glutamate, Hamposyl L salt, one or more in cocoyl sarcosine salt.
8. antibacterial tableware washing detergent liquid according to claim 5, which is characterized in that the thickener is cellulose thickener, melon
It is one or more in that glue and its double stearates of derivative species, PEG-120 methyl dioleate, Macrogol 6000.
9. antibacterial tableware washing detergent liquid according to claim 5, which is characterized in that the chelating agent is EDTA-2Na.
10. antibacterial tableware washing detergent liquid described in claim 5 is applied to meal wash field.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910437693.3A CN110100839A (en) | 2019-05-24 | 2019-05-24 | A kind of bacteriostatic agent combination and preparation method thereof and the application in antibacterial tableware washing detergent liquid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910437693.3A CN110100839A (en) | 2019-05-24 | 2019-05-24 | A kind of bacteriostatic agent combination and preparation method thereof and the application in antibacterial tableware washing detergent liquid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110100839A true CN110100839A (en) | 2019-08-09 |
Family
ID=67492066
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910437693.3A Pending CN110100839A (en) | 2019-05-24 | 2019-05-24 | A kind of bacteriostatic agent combination and preparation method thereof and the application in antibacterial tableware washing detergent liquid |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110100839A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112315826A (en) * | 2020-11-17 | 2021-02-05 | 江南大学 | Functionalized graphene quantum dot antibacterial hand sanitizer and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103602531A (en) * | 2013-11-26 | 2014-02-26 | 史东海 | Detergent |
| CN105709241A (en) * | 2016-03-23 | 2016-06-29 | 东南大学 | Preparation method of quaternary ammonium salinized fluorescent carbon dot and application of quaternary ammonium salinized fluorescent carbon dot in bacterium resisting and gram positive bacterium and gram negative bacterium differentiating |
-
2019
- 2019-05-24 CN CN201910437693.3A patent/CN110100839A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103602531A (en) * | 2013-11-26 | 2014-02-26 | 史东海 | Detergent |
| CN105709241A (en) * | 2016-03-23 | 2016-06-29 | 东南大学 | Preparation method of quaternary ammonium salinized fluorescent carbon dot and application of quaternary ammonium salinized fluorescent carbon dot in bacterium resisting and gram positive bacterium and gram negative bacterium differentiating |
Non-Patent Citations (5)
| Title |
|---|
| A. KHALFALLAH，: ""Antibacterial activity and chemical composition of the essential oil of Ammi visnaga L. (Apiaceae) from Constantine, Algeria"", 《INT. J. MED. AROM. PLANTS》 * |
| 大理白族自治州卫生局，: "《白族民间单方验方精粹》", 31 December 2015, 云南科技出版社， * |
| 张卫明，: "《一带一路经济植物》", 30 November 2017, 东南大学出版社 * |
| 张纪梅，: ""氮掺杂石墨烯量子点对Cr（Ⅵ）的选择性检测"", 《天津工业大学学报》 * |
| 张茜柳，: ""石墨烯量子点的抗菌性能及其在口腔医学中的应用前景"", 《口腔疾病防治》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112315826A (en) * | 2020-11-17 | 2021-02-05 | 江南大学 | Functionalized graphene quantum dot antibacterial hand sanitizer and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101955683B1 (en) | Eco-friendly hand-disinfectant composition containing extracts of natural material | |
| CN110150277A (en) | A kind of bacteriostatic agent combination and preparation method thereof and the application in Antibacterial laundry detergent | |
| CN109536296B (en) | Antibacterial biological detergent for infants and preparation method thereof | |
| JP6034118B2 (en) | Deodorant, antibacterial agent, and skin external preparation composition containing them | |
| CN110184135A (en) | A kind of antibacterial dish washing liquid of propolis and preparation method thereof | |
| WO2017199921A1 (en) | Antibacterial composition, and cosmetic composition and sheet-type product for skin comprising same | |
| CN108498372A (en) | A kind of disposable hand cleanser and preparation method thereof | |
| CN106366207B (en) | A kind of faenum graecum water-soluble polysaccharide hand cleanser and preparation method thereof | |
| CN110100839A (en) | A kind of bacteriostatic agent combination and preparation method thereof and the application in antibacterial tableware washing detergent liquid | |
| CN102206561A (en) | Pure plant bactericidal washing powder | |
| KR20060133122A (en) | Alginate microcapsule encapsulated extract of horseradish and preparation method thereof | |
| JP2004155901A (en) | Detergent using structured concentrated deep layer water | |
| CN105695157B (en) | A kind of environment-friendly liquid cleansing composition | |
| JP2005002008A (en) | Composition having function to prevent contact dermatitis | |
| CN108938486B (en) | Anticorrosive composite and its preparation method and application | |
| CN110585093A (en) | Hand-washing-free disinfection gel containing natural green tea extract and preparation method thereof | |
| US20240138419A1 (en) | Formulations, methods and uses thereof | |
| CN111904907A (en) | Efficient decontamination and bacteriostasis hand sanitizer and preparation method thereof | |
| CN105126149B (en) | A kind of medical recombination chitosan application | |
| AU2014270306A1 (en) | Use of a bacterium isolated from the genus pseudoalteromonas, cyclolipopeptides and uses thereof | |
| CN109679092B (en) | Preparation method of cosmetic-grade sodium polyaspartate | |
| CN108685802B (en) | Anticorrosive composite and its preparation method and application | |
| CN112043648A (en) | Camellia hand washing powder capable of moistening skin and cleaning and preparation method of camellia hand washing powder | |
| CN105435723A (en) | Toilet soap containing pomegranate polyphenol microcapsule and preparation method of pomegranate polyphenol microcapsule | |
| CN115279860A (en) | Ultrafine bubble generating agent and ultrafine bubble generating method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190809 |
|
| RJ01 | Rejection of invention patent application after publication |