JP6034118B2 - Deodorant, antibacterial agent, and skin external preparation composition containing them - Google Patents

Description

  The present invention relates to a deodorant and an antibacterial agent containing an extract from the fruit of Rita (Sapindus trifoliatus) as an active ingredient. More specifically, in order to suppress or reduce sweat odor, aging odor, which can suppress ammonia, acetic acid, iso-valeric acid, 2-nonenal, which is recognized with aging, in particular, sweat odor. The present invention provides a deodorant to be used, an antibacterial agent against Legionella pneumophila, and a body odor deodorant and anti-Legionella skin external preparation composition comprising these.

  In recent years, attention has been focused on various points around us with diversification of life, improvement of lifestyle, change and improvement of consciousness, and so on. One of them is a change in consciousness about bad odors. Garbage odor due to, for example, vegetables, eggs, livestock meat, and seafood treated as malodors is a mixed odor of hydrogen sulfide, methyl mercaptan, trimethylamine, ammonia, lower fatty acids, etc. Toilet odor is mixed odor of ammonia, methyl mercaptan, hydrogen sulfide, indole, etc., tobacco odor is mixed odor of ammonia, acetic acid, acetaldehyde, pyridine, hydrogen sulfide, etc., human body odor is ammonia, acetic acid, iso- It is known to have a mixed odor such as valeric acid and 2-nonenal.

  Particularly in recent years, under the deodorant boom, odorlessness is preferred, and the tendency to dislike odors has become stronger. For example, the so-called aging odor seen after middle-aged and older can be said to be one of the particularly disliked odors. It has been clarified that the body odor specifically generated with aging is due to 2-nonenal, which is a kind of unsaturated aldehyde.

  2-Nonenal has a tendency to increase specifically after the age of 40, which is considered the age at which an aging odor is generated (Non-patent Document 1), and the generation mechanism of unsaturated fatty acids ( 9-hexadecenoic acid) is said to be due to oxidation or degradation by skin resident bacteria.

  As a technique for suppressing the aging odor, a method of masking the generated unsaturated aldehyde with a fragrance component (Patent Document 1) and a method of capturing with ethanolamine (Patent Document 2) are known. In addition, by using an antioxidant to suppress oxidation (Patent Document 3), a lipoxygenase inhibitor to suppress formation of lipid peroxide (Patent Document 4), a method for suppressing the growth of causative skin resident bacteria (Patent Document 5), etc. A method of suppressing the generation of saturated aldehyde has been proposed.

  However, in particular, an inexpensive and highly safe deodorant that specifically and remarkably deodorizes odors caused by ammonia, acetic acid, iso-valeric acid, 2-nonenal, etc., which cause body odor, has yet to be developed. There is no actual situation.

  On the other hand, keeping the skin clean in daily life is very important not only for the prevention of body odors such as aging odors but also for the prevention of diseases, that is, from the viewpoint of hygiene. In recent years, it has become common to circulate hot water in hot springs and bath facilities, etc., so in the water circulation facilities used by multiple people such as public baths and medicinal baths, Legionella, E. coli Biohazard due to such issues is a serious problem. Similarly, cooling tower biohazard phenomena have also been reported in cooling towers used in heat exchangers for air conditioning and production processes, and aerosols contaminated by Legionella due to the widespread use of humidifiers in general households. It has been reported that inhalation of the human body can infect human bodies.

  Legionella pneumonia and Pontiac fever are examples of infections caused by Legionella spp. Legionella pneumonia is difficult to distinguish from other pneumonia only by symptoms, and because the progression of the disease is fast, diagnosis at medical institutions is difficult. Delays and inadequate treatment can result in death or serious consequences. Therefore, it is a disease that requires special attention for the elderly, newborns, and those suffering from diseases that cause a decline in immune function.

  Conventional antibacterial agents effective for Legionella include isothiazoline compounds (Patent Document 6), bronopol compounds, etc. These drugs are toxic, pH, temperature sensitive, chemical stability, biodegradable. There are limitations in terms of performance, suitability, etc., and not all can be handled. For example, in the case of the said compound, there exists a problem which causes an odor and metal corrosion. In addition, since there is a possibility of affecting not only microorganisms but also the human body, the optimum amount of use cannot be added, and as a result, there is a disadvantage that generation of microorganisms and algae cannot be sufficiently suppressed. .

JP-A-11-286428 JP 2001-97838 A JP-A-11-286423 JP-A-11-286424 JP-A-11-286425 JP-A-10-218710

The Journal of Investment Dermatology, 116, p520 (2001)

  The object of the present invention is to provide a low-cost and highly safe odor that specifically and remarkably eliminates odors caused by ammonia, acetic acid, iso-valeric acid, 2-nonenal, etc., which cause body odor, particularly sweat odor and aging odor. Odorant and safe, good brown-to-yellow color tone, stable without starch and discoloration with excellent antibacterial properties against skin hygiene, especially Legionella spp., Without adversely affecting the environment, human body and other animals The purpose is to provide antibacterial agents with good properties.

  Another object of the present invention is to remove body odor, particularly sweat odor, odor causing aging odor specifically and remarkably, and to have safe antibacterial properties against Legionella spp. It is an object of the present invention to provide a skin external preparation composition for body odor deodorization and anti-Legionella, which is extremely useful for the purpose.

  In the present invention, a plant extract is used from the viewpoint of low irritation to the skin. That is, the present inventors have examined a number of plant extracts and natural ingredients from the viewpoint of skin hygiene, and ammonia, acetic acid, iso-valeric acid, 2-nonenal causing body odor, especially sweat odor and aging odor. As a result of intensive research on the antibacterial properties against Legionella spp. With specific and remarkably deodorizing odors due to the odor, etc., the extract from the fruit of Rita (Sapindus trifoliatus) has a remarkable effect As a result, the present invention was completed.

  The present invention relates to a deodorant for odor caused by ammonia, acetic acid, iso-valeric acid, 2-nonenal and the like, an antibacterial agent against Legionella pneumophila, comprising an extract from the fruit of Rita (Sapindus trifoliatus) as an active ingredient The problems are solved by a composition for external deodorizing body and anti-Legionella skin containing the same.

  The deodorizer according to the present invention specifically and remarkably deodorizes odors caused by ammonia, acetic acid, iso-valeric acid, 2-nonenal and the like which cause body odor, particularly sweat odor and aging odor. The antibacterial agent is excellent in antibacterial activity against Legionella pneumophila. The extract from the fruit of Rita (Sapindus trifoliatus), which is an active ingredient in the present invention, has excellent effects and is safe. Therefore, the composition for external use of skin hygiene, especially for deodorizing body odor and anti-Legionella skin The same effect can be obtained by using it.

  It supplements about the plant used as an active ingredient in this invention. Rita (SAPINDUS TRIFOLIATUS) is a plant belonging to the order of Muclididae, which is distributed in South India and Pakistan, and its fruit is rich in saponins.

  An extract having a deodorizing action or an antibacterial action can be obtained by drying the fruit of Rita (SAPINDUS TRIFOLIATUS), which is a raw material for extraction, and then pulverizing it using a pulverizer and subjecting it to extraction with an extraction solvent. Drying may be performed in the sun or using a commonly used dryer.

  As the extraction solvent, a hydrophilic organic solvent or a hydrated hydrophilic organic solvent can be used, but ethanol and hydrated ethanol are particularly preferable, and extraction at room temperature is preferable at that time.

  Examples of water that can be used as the extraction solvent include pure water, tap water, well water, mineral spring water, mineral water, hot spring water, spring water, fresh water, and the like, and those subjected to various treatments. Examples of the treatment applied to water include purification, heating, sterilization, filtration, ion exchange, osmotic pressure adjustment, buffering, and the like. Accordingly, the water that can be used as the extraction solvent in the present invention includes purified water, hot water, and ion-exchanged water.

  Examples of hydrophilic organic solvents that can be used as extraction solvents include lower aliphatic alcohols having 1 to 5 carbon atoms such as methanol, ethanol, propyl alcohol, and isopropyl alcohol; lower aliphatic ketones such as acetone and methyl ethyl ketone; 1,3-butylene. Examples thereof include polyhydric alcohols having 2 to 5 carbon atoms such as glycol, propylene glycol and glycerin.

  When a water-containing hydrophilic organic solvent is used as a preferred extraction solvent, the mixing ratio can be adjusted as appropriate. For example, in the case of using a mixed solution of water and alcohol, when the amount of water is less than 60 parts by volume with respect to 40 parts by volume of water, poor stability such as starch and color appears. Therefore, it is preferable to mix 60 to 90 parts by volume of a lower aliphatic alcohol with 40 to 10 parts by volume of water.

  The extraction treatment is not particularly limited as long as the soluble component contained in the extraction raw material can be eluted in the extraction solvent, and can be performed according to a conventional method. For example, the extraction raw material can be obtained by immersing the extraction raw material in an extraction solvent in an amount 5 to 10 times (mass ratio) of the extraction raw material, extracting a soluble component at room temperature, and then removing the extraction residue by filtration. it can. The obtained extract is diluted, concentrated, dried, purified, etc. according to a conventional method in order to obtain a diluted or concentrated solution of the extract, a dried product of the extract, or a crude purified product or a purified product thereof. Processing may be performed.

  Purification can be performed by, for example, activated carbon treatment, adsorption resin treatment, ion exchange resin treatment, or the like. The obtained extract can be used as it is as an active ingredient of a deodorant, but a concentrated solution or a dried product is easier to use.

  In the extraction method, the solvent 1 to 20 is usually used for the plant 1, and the immersion extraction is performed for 1 hour to 1 week at room temperature to the boiling point of the solvent under normal pressure. Further, not only normal pressure but also high pressure or supercritical fluid can be used. After extraction, the solution is recovered by filtration, and purification such as deodorization and decolorization is performed as necessary. The extract obtained in this manner may be processed as it is or as needed, such as dilution and concentration.

  The fruit extract of Rita (SAPINDUS TRIFOLIATUS) obtained as described above has a deodorizing action, and in particular, has a deodorizing action against odors caused by ammonia, acetic acid, iso-valeric acid and nonenal. Therefore, it can be used as an active ingredient of a deodorant utilizing its action.

  At the same time, in particular, since it has an antibacterial action against Legionella pneumophila, it can be used as an active ingredient of an antibacterial agent by utilizing its action.

  The deodorant and antibacterial agent according to the present invention are: 1) topical or systemic external pharmaceutical preparations, skin cleansing agents, skin cosmetics, 2) medicinal or cosmetic preparations applied to the scalp / hair, 3) baths Medicinal or cosmetic bathing agent used in hot water 4) For deodorization in the form of impregnating liquids such as sheets for skin application, cosmetic sheets, cosmetic cotton, hygiene products, sanitary cotton, wet tissue, etc. It can be used by being appropriately blended with an external skin composition used for antibacterial purposes.

  Specifically, body odor deodorizers such as creams, gels, ointments, liquid medicinal skin external preparation compositions, lotions, emulsions, creams, ointments, gels, lotions, oils, packs, mists, facial cosmetic sheets, etc. Cosmetic composition, anti-legionella cosmetic composition, shaving agent, facial cleanser, skin cleanser (including soaps), shampoo, rinse, hair treatment, hair styling, hair nick, hair growth and hair restoration And makeup hair cosmetics such as medicinal or cosmetic hair preparations, foundations, lipsticks, blushers, eye shadows, eye liners, mascara, and the like.

  When producing the deodorant and antibacterial agent according to the present invention, and also when using these to produce a skin external preparation composition, it is generally used for external preparations such as cosmetics, quasi drugs and pharmaceuticals. The following components can be blended as appropriate or used as a solubilizer.

(Various oils and fats)
Avocado oil, almond oil, fennel oil, egoma oil, olive oil, orange oil, orange rafa oil, sesame oil, cacao butter, chamomile oil, carrot oil, cucumber oil, beef tallow fatty acid, cucumber nut oil, safflower oil, shea fat, large Bean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, cocoa butter, palm oil, palm kernel oil, owl, palm oil, beef tallow Or hydrogenated products of these oils and fats (hardened oil, etc.).

(Wax)
Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax.

(mineral oil)
Liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, micro-cristan wax, squalene, squalane, pristane, etc.

(Fatty acids)
Natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid , Synthetic fatty acids such as 2-methylpentanoic acid, 2-ethylhexanoic acid and isopentanoic acid.

(Alcohol)
Natural alcohols such as ethanol, isopyropanol, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol and phytosterol, and synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol and 2-octyldodecanol.

(Polyhydric alcohols)
Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol, polypropylene glycol, 1,3-butylene glycol , Glycerin, pentaerythritol, sorbitol, mannitol, etc.

(Esters)
Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, diethyl phthalate, phthalate Dibutyl acid, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, etc.

(Metal soap)
Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate, etc.

(Gum, sugars and water-soluble polymer compounds)
Gum arabic, benzoin gum, danmar gum, guaiac gum, Irish moss, Karaya gum, tragacanth gum, carob gum, quinseed, agar, casein, lactose, fructose, sucrose and its esters, trehalose and its derivatives, dextrin, gelatin, pectin, starch, Carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2 to C4) chitin or chitosan to which alkylene (C2 to C4) oxide such as ethylene oxide is added, low molecular chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorus Oxidized chitin or chitosan, alginic acid and its salt, hyaluronic acid and its salt, chondroitin sulfate and its salt, heparin, ethylcellulose, methylcellulose, carboxymethylcellulose, carboxy Polyalkylene oxide such as chill cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyethylene oxide and polypropylene oxide or Its cross-linked polymer, carboxyvinyl polymer, polyethyleneimine, etc.

(Surfactant)
Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate ester salt, alkyl phosphate ester salt), cationic surfactant (alkylamine salt, alkyl quaternary ammonium salt), amphoteric surfactant: carboxylic acid Type amphoteric surfactant (amino type, betaine type), sulfate type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant (ether type nonionic surfactant) Agents, ether ester type nonionic surfactants, ester type nonionic surfactants, block polymer type nonionic surfactants, nitrogen-containing type nonionic surfactants), other surfactants (natural surfactants, proteins) Hydrolyzed derivatives, polymer surfactants, surfactants containing titanium and silicon, fluorocarbon surfactants Such as.

(Various vitamins)
Vitamin A group: retinol, retinal (vitamin A1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), Pyridoxine (vitamin B
6), cyanocobalamin (vitamin B12), folic acid, nicotinic acid, pantothenic acid, biotins, choline, inositol, vitamin C group: ascorbic acid and its derivatives, vitamin D group: ergocalciferol (vitamin D2), cholecalci Ferrol (vitamin D3), dihydrotaxosterol, vitamin E group: tocopherol and its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K2), menadione (vitamin K3), menadiol (vitamin K4), In addition, essential fatty acids (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamin U and the like.

(Various amino acids)
Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine And amino acid derivatives such as sulfates, phosphates, nitrates, citrates, or pyrrolidone carboxylic acids.

(Various additives derived from plant or animal materials)
These are processed in a conventional manner according to the type and form of the product to be added (eg grinding, milling, washing, hydrolysis, fermentation, purification, pressing, extraction, fractionation, filtration, drying, pulverization , Granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc., may be arbitrarily selected and combined), and may be arbitrarily selected from various materials.

  The solvent used for the extraction may be selected in consideration of the intended purpose and type of the product to be provided, or the processing performed later. Usually, water, a water-soluble organic solvent (for example, ethanol, propylene glycol) , 1,3-butylene glycol, etc.) is preferably used. However, when it is not preferable to contain an organic solvent depending on the use, it is sufficient to use only water or ethanol that is easy to remove after extraction, and it may be used alone or in any mixture with water. The thing extracted and extracted may be sufficient.

  In addition, when various additives derived from plant or animal materials are applied to systemic or topical skin external preparations, it not only protects skin and hair, but also moisturizes, improves touch and texture, and imparts flexibility. , Relaxation of stimulation, relaxation of stress due to fragrance, cell activation (prevention of cell aging), suppression of inflammation, improvement of skin quality / hair quality, prevention of rough skin and its improvement, hair growth, hair growth, prevention of hair loss, imparting luster, cleanliness In addition to cosmetic effects such as effects, fatigue relief, blood flow promotion, and warm bath effects, effects such as flavoring, deodorizing, thickening, preserving, and buffering can also be expected.

Specific plants (herbal medicines) used as raw materials include, for example, almond (amynna), ai (indigo leaves), aokazura (Keifu Fuji), aotsuki-rafuji (wood moth), aonorus agave, fuchlin agave, acacia, acassuri fruit, Red grapes, redwood (logwood), red-crowned wrinkles, red radish (radish grass roots), red radish (dianthus), agi (Aki), echini (crustacean), akebi (kitsu), asa (asako) , Maruba morning glory or morning glory (seasoned cow), Hydrangea (hydrangea), Achacha (Amacha), Ashitaba (Asuka leaves), Amana (Ako), Acerola, Anise, Abemaki fruit, Avocado, Ama, Achacharu, Amadokoro (Tamatake), Amigasayuri (shellfish mother), Aloe Vera, Angelica, Anzu Honganzu (Anjin), Ansokkou (benzoic incense), Igakouzorina (Gallhead) Rush (shinshin grass), Japanese knotweed (tiger cane), strawberry, fig (no flower fruit) or its leaf, Ichihatsu (first), Ichibibi (winter lion), Ichiyakusou (one medicinal herb), Ichihahagi (distant), locust bean, rice seeds or Seed coat, Inondo seed, Ikisakuso, Nettle, Ylang-Ylang, Fennel (Yellow perfume), Spiraea (Sanryo), Astragalus fruit, Amaranthus japonica, Turmeric (Urbanus), Usubasaicin, Keirinsaicin (Spicy), Usbeniah, Usbeni Hollyhock, deer (summer hay), Japanese apricot (plum) or its flesh, radish, oolong tea, walrus (redberry), Eunsumikan (skin peel), estragon, Ekokogi (蝦 夷 goka), echinashi (Hosobamurakibarengikue), Echinacea榎 茸), Elderberry fruit, Elemi, Elingy (Prerotor) Erinji), Enju (槐花, 槐花 米), Ogi, Kibana-ogi (Yellow), Oulen (Yelen), Pteropus lily (Karonin), Otsu Rafuji (prevention), Psyllium (pre-car, pre-cursor), Toucan ( Eggplant), Ovanaokera, Okera (white birch), Obayayashabushi fruit, Sea hawthorn hawthorn (Yamakoko), Ousei (Naruyori, Kagura-mabanaruyori), Sasayukiyuki, Sasanoyuki, Barley, Grained Grass (Turnover), Okra fruit, Panax ginseng, Tochibaninjin (carrot), Onamomi (Cotton ear), Onigurumi, Onino Yagara (Tempa), Onyuri Sasayuri Hakatayuri (Yuri), Onionis, Halibut (Flyer), Ominaeshi (defeat) Soy), Dutch mustard (watercress), Dutch jellies, Dutch honey bees, olives (fruit, seeds, leaves), oregano, me Di-fruit or pericarp, Silkworm (mature ground yellow), cacao seeds, oysters or their leaves (bamboo shoots), scallops (fish potatoes), cassia, casino berries (fruits), gadgets (bamboo shoots), oak (Leaf), cascarilla, cynomolgus (gold sato), valerian (valerian), birch or fern birch (white birch), pumpkin, kapok seed, kahoku salamander (sweet potato), gama (claw yellow), chamomile, roman chamomile, chamomile ( Tsutsumo), Kamukamu / Duck, Duck (Camellia), Crowd Bisaku (Semi-Summer), Oats, Garana Seeds, Calahoo (Park), Karaya, Karin (Kiso), Garcinia, Kawaratake, Ishikawa Rana (Isotake) , Buckwheat), Chinese mugwort (boiled chin), kansui (kansai), cantalara, candelilla, kanto, kanna, raspberry (Ezo strawberry, Dutch strawberry) Shrimp Strawberry, Narrow White Strawberry, Momiji Strawberry, European Red Strawberry), Kiwi Fruit, Kikarasuuri (Gurone), Chrysanthemum (Chrysanthemum Flower, Striped Ginkgo, Chrysanthemum), Kisage (Kashimi), Shigegishi (Yotei), Kizuta, Kizuta, Kidachi aloe, Kidachi pepper, Kinanoki (Cinchona, Red linden), Gymnema sylvesta, cabbage, cabbage immature fruit, cucumber, Kiraja saponaria, Kiraya, Kiranso (Kinza licorice), kumquat fruit, betel, Kimizuki (Sentsukusa), guava fruit, Guayule, cucumber nuts, wolfberry (bamboo shoots, coconut palm, cocoon leaves, crustal skin), cedar casserole (Tenmon winter), camphor tree, gooseberry fruit, gardenia (mountain lion), kunugi (bamboo grass), kumazasa, pine moth (hortiform grass), Clara (bitter), cranberry fruit, chestnut or its astringent skin, kurukuri・ Ratifolia fruit, grapefruit, buckthorn, black beetle (necessary), clove (clove, clove), kei-gai (cage, cocoon), celosia (chicken flower, chicken clover), bay cabbage (laurel tree), Kenashi Sartorii rose (crust, Mountain return), Gentiana, Kouji / Tachibana / Obenimikan / Ponkan / Santara (Tachibana skin), Koshinbara (moon flower), Kousei mint, Kozo fruit, Kocha (tea), Kohone (river bone), Kohon (Kanhon, Karamoto) , Kouliang, Cilantro fruit, Cowberry (Etsutachibana), Coconut fruit, Goshuyu (Gyuyu), Goshostrawberry (Pepper), Pepper (Pepper), Copaiba balsam, Coffee beans, Kobushi magnolia (Cotton), Burdock (Beef bowl, Gyudon) Child), kobane eel, sesame (sesame), sesame seedling (genus ginseng), trash (gomiko), sanekazura, binankazura, matsubusa, Wheat (wheat), rice, rice bran (red cocoon, white birch), rice oil, cola acminata seeds, cola vera seeds, fenugreek fruit, colombo, condurango, konjac, sisal, sisal asa, saxima button leopard (wei Sensen), cherry ( Leaf, flower, fruit, bark (cherry bark), cherry, pomegranate, sasa, sasanka, cherry tree, cherry tree, cherry tree, cherry tree, cherry tree, cherry tree, cherry tree, cherry tree, cherry tree, cherry tree, cherry tree, cherry tree, cherry tree, cherry tree (Bamboo shoots), sweet potatoes, sugar cane, sugar beet, sunflower jujube (acid vine), saffron (banju blossom, west red blossom), pomelo fruit, savonso, salmon berry, salamander, salvia (sage), ragweed (mountain) Chinese cabbage), Sawagurumi (wild walnuts), Carrot (Ginseng), Sanshuyu (Yamamuro), Sansho (Yamamuro), Sandskon (Yamazune), Shia (Kalite), Cyano fruit, Shiitake mushroom (Shitake), Zion (purple lees), Jikitaris, Sikunshi (Amiko) , Shiso Aojiso Chirimenji Katamenjiso (Shiyo leaf, Shiso child), Rosewood, Shinanoki, Sinahoonoki, Shirarenyou (ream), Shimeji (Hinshimeji, Shakashimeji, Hatake-Shimeji, Oshiro-Shimeji, Buna-Shimeji, Shirotamotake-mochi) (Glaze), shajin (shasan), jade beard (barley winter), juzudama, palm fruit, ginger (ginger), ginger (salmon, root), shozuk fruit, shirakashi seeds, white butterfly seeds, white squirrels , Shirobanatsuta flowers, Shirominanten (Minami Tenmami), Cinchona Sacylbra, Jincho Gue (Mizuka, Mizuka, Shencho), Cinnamon, Watermelon (Sairan), Sorrel (Acami), Swimberry fruit, Stevia, Strawberry fruit, Suzu-Psycho (Xucho), Suginah (question), Surihiyu (horse tooth tendon, Horse tooth (Kenshi), Plum fruit, Japanese red pine cone, Japanese larch, Japanese kizuta, Japanese walnut, Japanese hawthorn, Japanese dandelion, Japanese horse chestnut (Mallonier), Japanese pear fruit, Japanese yellow cherry, Japanese elderberry (Elder), Japanese juniper (Juniper)・ Etsumatsu), rose, pearl butterfly, mistletoe, yellow mint, yellow mint, horseradish, peony (Ishizone), mallow, hirosanega, senega, seri, celery, sendan, senburi (this drug), senna fruit Or leaves, sennin Cormorant (Daisatsu), Soka (grass), buckwheat seeds, Somerna potato, Daio (Dahi), Daikon radishes, Daidai (orange peel, walnuts), Takatodai (Daigai), Takakawarabi (Cirrus), dark sweet cherry fruit, hollyhock , Tachikakuso (Thyme, Perilla), Tachiyanagi, Tamarind Seed, Onion, Tamshiba (Pepper), Taranoki or its root bark, Tanjin, Dandelion (Sankou) or Shirobana Dandelion, Mokodanpopo, Danmaru, Cherry fruit, Chigaya or Its root (Sone), Chixetsu carrot (Bamboo ginseng), Chicory, Ginseng (Dahi), Korean ginger (Ginseng), Ginseng (Ginseng), Ginseng (Ginseng leaves), Choreimaitake (Tsumami) , Tsukuritake (mushroom), camellia, camellia, clover (lacquered grass), camellia (duck grass), azuki bean (red bean), tsuruna ( Apricot), Tsuru carrot (Yoba ginseng), Azabuki, Deco, Teuchigurumi, Duberry fruit, Tengusa, Tencha (boiled tea), Tendai Yaku (glaze), Toga (winter coconut), Pepper (banyu), Tokinsenka (marigold), Maize or corn hair (Southern cocoon hair), Japanese horned potato (Sadako), Torindo (dragon gall), Tokusa (wood band), Tokon (gump root), Toshishi-Mamedaoshi Neashikazura, Tochu (Tochu, Tochu), Toneriko ), Tomato, tragacanth, triacanthus seeds, tormentilla, dronoki, taro aoi, nigerian berry fruit, yam yam (wild boar), nagii kada (butcher bloom), naginata koju, nazuna, rapeseed, jujube, jujube (Sakurako), Nameko, Naruko Yuri (yellow spirit), peanut (peanut), niga Fruits, flowers or stems, (garlic), garlic (large persimmon), Nurde, (bitter tree), Japanese mugwort (bitter melon), nutmeg, Kay, Nikkei (cinnamon bark), Keishi (Katsura branch), leeks (lion) (Penta), leek, white thistle (large coral), yarrow, nodake (former cucumber), wild rose, peach, palm, pineapple fruit, hibiscus (bushouge, furinbusouge, roselle), hakamabo labushi (bone crush), hakusen (white crust) ), Hakuru Berry Fruit, Jacobe (Fresh), Hazel (Chicken), Hashiridokoro (Roth Root), Basil, Lotus (Lotus, Lotus Meat, Lotus), Parsley (Netherlands Jelly), Hakamagi, Batata, Hachiku Madake (Bamboo Mushroom) , Patchouli, mint (light load, light load), flower moth (wisdom mother), banana, hana mint, hanabashi (shitsuri, shitsutsuri), vanilla bins, papaya, scallops (hub grass), hub grass, paprika, hamago Umi Mitsuba Clam (Vulgaris), Hamasuge (Katsukiko), Habibishi (Shitsuko), Hermanus (Maika Flower), Rose (Rose), Agaric (Agaric, White-faced Agaric, Uskimorinokasa), Parietalia, Harunile (Crustacea) , White skin, green leaves), breadfruit, lizard carrot (participant), pecan nuts, longan beetle (stone wall, vine pearl flower), hishi (rhizomi), pistachio, beet, honey tree, stone wall fern, Hinata Kozuchi (cow knee), cypress, hiba, castor, sunflower, bell pepper, himegama (incense bud), himematsutake (prickly agaric mushroom, hiromatsutake), pimenta fruit, juniper, sandalwood, yellow-bellied fruit, broad-tailed oyster, white-headed cypress (枇杷, 枇杷葉), betel wax (large clothes, coconut), Japanese quail (southern rattan), Japanese pheasant, Japanese dandelion (Japanese winter flowers, Japanese winter leaf), Fujibaka Maize (Orchid), wisteria bean (peel), grape fruit or pericarp / seed / leaves, beech, Fuyumushinatsutake (Cycium edulis), Brazilian licorice, Brazilian carrot, black currant fruit, blackberry, plum fruit, fluceraria, blueberry ( (Prunus), prune, blond psyllium, bundo (mung bean), loofah, henken, belladonna, berry fruit, pervian burger, boysenberry fruit, spinach, physalis (Torone), honoki (Japanese rustic, pak), bokeh ( Kiso), Hosobanaokera (蒼朮), Hosobabarengiku, Hops, Jojoba, White berry fruit, Honshimeji, Mizurutennansho (Tennansei), Maitake (Maiko), Macadamia nuts, Macri (Seaman grass), Magnolia sprengeri, Matabi ( Wood tengu), Matsukasa, Matsuba, Mayoram Malvanojadine (bitter ginseng), mulberry fruit, quince, mango, mangosteen, mango gurumi, mandarin fruit, mandarin fruit (ganoderma), citrus fruit (fruit), mandarin orange (shiba), mizokakushi (half-sided lotus), misohagi Chikuma), Mitsuwashi, Mitsuba, Green mint, Mimosa, Mioga, Miracle fruit fruit, Myrrh, Milobaran, Mugge (Mushroom), Mukunoki, Mukuroji, Murasakikikibu, Omurasakikib (purple pearl), (Murasaki maize, Mehajiki (benuse) Meowugi, Melaleuca, Merirot, Melon fruit, Moukomomogi, Mosouchiku, Mokko (wooden incense), Japanese maple peach, Peach leaf (peach leaf) / fruit / seed (peach seed), Moyashi, Morello cherry fruit, Morohaya (burlap), Yakawa Purple potato, yakchi (masutachi), cornflower (cornflower), ya Rumahakka, Yachiyanagi, Millipede (octagonal gold plate), Mistletoe (willow parasitism), Willow tree leaf, Yabgarashi, Yabukouji (purple gold beef), Japanese burdock (shoku land), Yamahanoki (yamabe), Japanese yam (Japanese apricot), Japanese mugwort, Yucca・ Flevifolia, yuzu fruit, lily, yorogusa, lime fruit, rye, rakanka fruit, raspberry leaf / fruit, lavender, longan (longan), ryokcha (green tea), apple fruit, gentian, lubus suabisimus (cool), lettuce, Red currant fruits, lemon fruits, lemongrass, forsythia, forsythia, wax palm, locon (reeds: roots), loganberry fruits, rose hips (no roses), wasabi, and warm mocows (ground).

  In addition, the raw materials derived from animal materials include chicken crown extract, pig / cow stomach, duodenum or intestinal extract or degradation product thereof, pig / cow spleen extract or degradation product, pig / cow brain Extracts of tissues, collagen derivatives such as water-soluble collagen and acylated collagen, collagen hydrolysates, elastin, elastin hydrolysates, water-soluble elastin derivatives, keratin and its degradation products or their derivatives, silk proteins and their degradation products Or their derivatives, porcine / bovine blood cell protein degradation products (globin peptides), porcine / cow hemoglobin degradation products (hemin, hematin, heme, protoheme, heme iron, etc.), milk, casein and its degradation products or derivatives thereof, Non-fat dry milk and its decomposition products or derivatives thereof, lactoferrin or its decomposition products, chicken egg components, fish decomposition products, etc.

(Microbial culture metabolites)
Yeast metabolites, yeast extract, rice fermented extract, rice bran fermented extract, Euglena extract, trehalose or its derivatives.

(Inorganic pigment)
Silica, magnesium silicate, talc, kaolin, bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide , Gunjo, chromium oxide, chromium hydroxide, carbon black, calamine, etc.

(UV absorption / screening agent)
p-aminobenzoic acid derivatives, salicylic acid derivatives, anthranilic acid derivatives, coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, Allantoin derivatives, nicotinic acid derivatives, vitamin B6 derivatives, benzophenones, oxybenzone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, urocanic acid derivatives, escalol, zinc oxide, talc, kaolin and the like.

(Astringent)
Succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannic acid (including catechin compounds).

(Active oxygen scavenger)
SOD, catalase, glutathione peroxidase, etc.

(Antioxidant)
Ascorbic acid and salts thereof, stearic acid ester, tocopherol and ester derivatives thereof, nordihydrogua ceretenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, propyl gallate, sesamol , Sesamorin, gossypol, etc.

(Humectant)
Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid and its salt, polyethylene glycol, chondroitin sulfate and its salt, water-soluble chitin or chitosan derivative, pyrrolidone carboxylic acid and its salt, sodium lactate, mini sasanishiki extract, etc.

(Peripheral blood flow promoter)
Vitamin E and its derivatives, assembly extract, garlic extract, carrot extract, gentian extract, toki extract, cephalanthin, carpronium chloride, minoxidil and the like.

(Local stimulant)
Pepper tincture, nonyl acid vanillamide, cantalis tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(Metabolic active agent)
Photosensitive element 301, hinokitiol, pantothenic acid and its derivatives, allantoin, biotin, pentadecanoic acid glyceride and the like.

(Anti-seborrheic agent)
Pyridoxine and its derivatives, sulfur, vitamin B6 and the like.

(Oxidant)
Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, sodium pyrophosphate, sodium orthophosphate Sodium silicate hydrogen peroxide adduct, sodium sulfate sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract and the like.

(Fragrance)
Natural animal flavors such as musk, civet, castrium, ambergris, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, guayakwood essential oil, cumin essential oil, black letter Essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriander essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, western peppermint essential oil, dairy perfume essential oil, Tuberose Essential Oil, Clove Essential Oil, Orange Flower Essential Oil, Winter Green Essential Oil, Truval Sam Essential Oil, Batule Essential Oil, Rose Essential Oil, Palmarosa Essential Oil, Agate Essential Oil, Hiba Essential Oil, Sandalwood Essential Oil, Petit Glen Essential Oil, Bay Essential Oil, Vetiver Essential Oil, Bergamot Essential Oil, Pe -Plant flavors such as balsam essential oil, boad rose essential oil, melamine essential oil, mandarin essential oil, eucalyptus essential oil, lime essential oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary essential oil, Japanese mint essential oil, and other synthetic flavors .

(Dye and colorant)
Red cabbage dye, red rice dye, red dye, anato dye, squid dye, turmeric dye, enju dye, krill dye, amber dye, caramel, gold, silver, gardenia dye, corn dye, onion dye, tamarind dye, spirulina dye, Whole buckwheat pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.

(Other)
Moisturizers, hormones, sequestering agents, pH adjusters, chelating agents, antiseptic and antibacterial agents, cooling agents, stabilizers, emulsifiers, animal and vegetable proteins and their degradation products, animal and vegetable polysaccharides and Its degradation products, animal and plant glycoproteins and their degradation products, blood flow promoters, anti-inflammatory agents, anti-allergic agents, cell activators, keratolytic agents, wound treatment agents, foam enhancers, thickeners, deodorizers A deodorizing agent, an enzyme, etc. are raised, By using together with these, various additive and synergistic effects can be expected.

Manufacture of Rita fruit extract liquid Rita (SAPINDUS TRIFOLIATUS) fruit hydrous organic solvent (EtOH: ethanol, PG: propylene glycol, BG: 1,3-butylene glycol) (10 parts by weight) After extraction at room temperature for about 2 weeks, the extract is filtered and stored in a freezer at −30 ° C. for 1 week. Then, it filtered again and manufactured.

Evaluation of properties and stability of Rita fruit extract The results of the following table (Tables 1 to 3) were obtained when the stability of the extract produced in the Examples was evaluated, such as the occurrence of starch and color tone. It was. With regard to stability, when a solvent having a hydrophilic organic solvent content of 85.7% by weight (= 90.0% by volume) or more is used, a good brown to faint yellow color tone and stable extraction without starch / discoloration The liquid was evaluated as being obtained.

Deodorization test for 2-nonenal (test method)
Each specimen was put in a scented bag and heat sealed, and then air was enclosed and 2-nonenal gas was added to a set gas concentration to 4 L. This was left to stand, and 300 mL of gas in the bag was collected in a DNPH cartridge every elapsed time. The DNPH derivative was eluted through 5 mL of acetonitrile on a DNPH cartridge collecting the gas, and this eluate was measured by high performance liquid chromatography to calculate the gas concentration in the bag. The operating conditions of the high performance liquid chromatograph are shown below. In addition, a blank test was performed by performing the same operation without inserting a specimen.

(Sample) Product No. 1, No. 1 4, no. 7 is spray-dried

(High-performance liquid chromatograph operating conditions)
Equipment used: LC-2010AHT (manufactured by Shimadzu Corporation)
Detector: UV absorption detector column: RP-Amide, φ4.6 mm × 25 cm (manufactured by Sigma Aldrich Japan Co., Ltd.)
Column concentration: 40 ° C
Mobile phase: A mixture of acetonitrile and water (80:20)
Mobile phase flow rate: 1.5 mL / min
Measurement wavelength: 360 nm

(Measurement of 2-nonenal reduction rate)
Based on the measured values measured as described above, the decrease rate (%) of Nonenal was calculated by the following (formula).
(Formula) 2-nonenal decrease rate (%) = {(S0−Sn) / S0} × 100
In the formula, S0 represents the nonenal concentration before the start of the test, and Sn represents the nonenal concentration n minutes after the start of the test.

(Test results)
Table 4 shows the reduction rate of 2-nonenal with time. The extract of Rita fruit extracted with an organic solvent having a high water content showed a slightly higher 2-nonenal reduction rate.

Other deodorant test (test method)
After setting the room temperature to 20-25 ° C and stabilizing the room temperature, inject a specified amount of malodorous substance into 3L of odor bags (Omi Odo Air Service Co., Ltd.) and immediately after that, the odor bags are full. After being filled with air until it became, the odor bag was sealed and left for 10 minutes (referred to as odor bag A). Separately, a new same odor bag was prepared, and a specified amount of specimen was injected (referred to as odor bag B). Next, the smell bags A and B were connected with a tube tube, and all the air in the smell bag A was transferred to the smell bag B, immediately sealed and allowed to stand for 10 minutes, and then the residual malodorous substance concentration was measured using a dedicated gas detector tube. . In each test, n = 3 for each sample, and the average value was calculated by obtaining the deodorization rate (%) by the following formula. The blank was operated without sample injection, and the residual odorous substance concentration was measured.
Odor substance reduction rate (%) = {(blank value) − (specimen value)} / (blank value) × 100

(Odorous substances and prescribed amounts)
a. Acetic acid (use 10 μL after 100-fold dilution)
b. n-butyric acid (use 10 μL after 10-fold dilution)
c. n-Valeric acid (stock solution, 20 μL used)
d. Isovaleric acid (use 10 μL after 10-fold dilution)
e. 28% aqueous ammonia (5 μL used after 10-fold dilution)
f. 30% trimethylamine (10 μL dilution, then use 20 μL)
g. 1 μg / μL methyl mercaptan (stock solution used 40 μL)

(Specimen and specified amount)
Product No. 4, no. 7, no. 8 spray-dried ... 0.5g each
1% by weight purified water suspension of each product dry product ... 0.5 mL each
Purified water ... 0.5 mL

(Gas detector tube)
Gas detector tube no. 81L made by GASTEC (used for acetic acid, butyric acid, valeric acid)
Gas detector tube no. 3L made by GASTEC (used for ammonia and trimethylamine)
Gas detector tube no. 70L made by GASTEC (used for methyl mercaptan)

(Test results)
Each malodorous substance reduction rate (%) was as shown in Table 5.

Odor control test by washing (test method)
Cut the pork skin into 1 x 2 cm size, apply a specified amount of malodorous substance on the surface, leave it at room temperature for 15 minutes, and then spray a foamed sample (manufactured product No. 7 extract of Rita fruit) A 1% aqueous solution was prepared using the dried one, placed in a foam-forming container, 2 push 2 g amount) was applied, and the foam was washed 20 times so as not to touch the surface. Next, the pig skin was washed with running water for 5 seconds (test product). As a blank, a pig skin not coated with a malodorous substance was prepared and washed with running water in the same manner. As a control, after the malodorous substance was applied, the foamed sample was not used, and was similarly washed with running water. The surface of the pig skin was sniffed by a monitor (12 to 14 persons), and the odor suppression effect by sample washing with respect to the control was performed by a sensory test.

(Evaluation method)
Judgment method was based on Visual analogue scale (VAS) for quantifying subjective evaluation and 6-step odor intensity display method. Each odor of the control and the test product was scored based on the following criteria, and the difference between the control and the test product was evaluated by a point system.
0: Odorless 1: A smell that can be finally detected 2: A weak odor that tells what the smell is 3: A smell that can be easily detected 4: A strong smell 5: A strong smell 6: I do not know (standard by point system)
0 points ... 1 point not changing ... I feel a slight decrease in odor.
2 points ... I feel a decrease in smell.
3 points: I can feel the reduction of smell clearly.
4 points or more ... The odor almost disappeared.

(Odorous substances and prescribed amounts)
a. Acetic acid (Add 0.5 mL to 100 mL with distilled water, use 30 μL)
b. Isovaleric acid (Add 1 mL of distilled water to 100 mL, add 0.5 mL of distilled water to 100 mL to make 100 mL, and use 10 μL)
c. Ammonia (by adding 1,3-butylene glycol to 7.2 mL of 28% aqueous ammonia to make 100 mL, use 100 μL)
d. 2-nonenal (add 1,3-butylene glycol to 0.7 mL to make 100 mL, use 30 μL)

(Test results)
The evaluation results of the odor suppression test by washing are shown in Table 6.

Legionella growth inhibition test (test method)
Legionella-Combi-Pack was inoculated into Legionella-Combi-Pack, cultured at 37 ° C. for 24 hours, and then prepared using physiological saline so that the number of bacteria was 10 ⁸ / mL. A test sample was prepared by adding sterilized water to the spray-dried sample to adjust the solids concentration to 1% and 0.1%. Each test sample solution was inoculated into 10 mL of a test sample in an amount of 0.1 mL and cultured at culture temperatures of 25 ° C., 35 ° C., and 37 ° C. Immediately after culturing, the number of viable bacteria in each test sample was measured using a dilution culture method after 1 hour, 12 hours, and 24 hours. As a control, a test using only sterilized water was also conducted.

(Sample)
Product No. 7

(Test results)
The evaluation results of the Legionella growth inhibition test were as shown in Table 7.

Safety test (skin irritation test)
What was prepared in the purified water so that it might become 0.1 weight% and 1.0 weight% by spray-drying the extract (product No.7, No.15, No.23) of the Rita fruit manufactured in the Example. A 24-hour closed patch test was performed on 20 male and female monitors as samples. Using a patch tester “Torii”, the sample was subjected to occlusion on the left and right upper arm flexors for 24 hours for determination. The sample was removed 24 hours after application, and after 24 hours, 48 hours, and 1 week later, the skin condition was observed and judged. As a result, no abnormality was observed in any of the samples. I couldn't.

Manufacture of skin external preparation composition Various skin external preparation compositions were manufactured using the deodorant and antibacterial agent of this invention. The formulation example is as follows, and the blending amount indicates% by weight.

(Soap)
・ Soap base 85
・ Product No. 7 spray-dried products
・ Purified water 10

(Soap)
-Monosodium N-lauroyl-L-glutamate 64
N-oleoyl-L-monosodium glutamate 10
・ Myristyl alcohol 5
・ Lauric acid diethanolamide 2
・ Edetic acid disodium 0.2
・ Titanium oxide 0.1
・ Product No. 23 10
・ Remaining amount of 100 purified water

(Soap)
・ Cetanol 10
・ Dibutylhydroxytoluene 0.02
・ Product No. 7 spray-dried products 1
・ Coloring agent Trace amount ・ Natural oil soap base (40% beef tallow, palm oil 20%, NaOH 30%, moisture 10%)

(Deodorant spray)
・ Methylphenylpolysiloxane 1.31
-Isononyl isononanoate 2.25
・ Triclosan 0.02
・ Trichlorocarbanilide 0.02
・ Menthol 0.1
・ Chlorhydroxyaluminum 1.5
・ Silica 3.0
・ Talc 1.7
・ Perfume 0.1
・ Product No. 7 spray-dried product 1.0
・ Liquefied petroleum gas remaining

(Deodorant spray)
・ Methylphenyl polysiloxane 0.51
・ Isopropyl myristate 2.86
・ Isopropylmethylphenol 0.01
・ Trichlorocarbanilide 0.02
・ Menthol 0.05
・ Zinc oxide 0.5
・ Silica 4.3
・ Talc 1.6
・ Perfume 0.1
・ Product No. 5 spray dried product 1.0
・ Liquefied petroleum gas remaining

(Deodorant spray)
・ Ethanol 37.96
・ Menthol 0.3
・ Methylphenyl polysiloxane 1.0
・ Triclosan 0.1
・ Benzalkonium chloride 0.04
・ Zinc paraphenolsulfonate 0.2
・ Fragrance 0.4
・ Product No. 15 10
・ Liquefied petroleum gas 100

(Deodorant spray)
・ Ethanol 38.36
-Isononyl isononanoate 1.0
・ Isopropylmethylphenol 0.05
・ Benzalkonium chloride 0.04
・ Zinc paraphenolsulfonate 0.15
・ Fragrance 0.4
・ Product No. 23 10
・ Liquefied petroleum gas 100

(Deodorant roll-on)
・ Ethanol 60.0
-Isononyl isononanoate 1.0
・ Triclosan 0.2
・ Zinc pyrithione 1.0
・ Chlorhydroxyaluminum 10.0
・ Menthol 0.3
・ Fragrance 0.4
・ Product No. 7 10
・ Remaining amount of 100 purified water

(Deodorant roll-on)
・ Ethanol 60.0
-Isononyl isononanoate 1.0
・ Isopropylmethylphenol 0.1
・ Zinc pyrithione 1.0
・ Chlorhydroxyaluminum 10.0
・ Menthol 0.1
・ Fragrance 0.2
・ Product No. 6 10.0
・ Remaining amount of 100 purified water

(Deodorant lotion)
・ Ethanol 20.0
・ Polyoxyethylene hydrogenated castor oil 1.0
・ Dipropylene glycol 2.0
・ Isopropylmethylphenol 0.1
・ Piroctone Olamine 0.2
・ Zinc paraphenolsulfonate 0.3
・ Fragrance 0.3
・ Product No. 15 5
・ Remaining amount of 100 purified water

(Deodorant lotion)
・ Ethanol 30.0
・ Polyoxyethylene polyoxypropylene decyl tetradecyl ether 0.5
・ Triclosan 0.2
・ Piroctone Olamine 0.2
・ Zinc paraphenolsulfonate 0.3
・ Menthol 0.2
・ Fragrance 0.2
・ Product No. 6 10.0
・ Remaining amount of 100 purified water

(Deodorant Mist)
・ Ethanol 70.0
・ Benzalkonium chloride 0.1
・ Trichlorocarbanilide 0.1
・ Allanto chlorohydroxyaluminum 0.5
・ Menthol 0.1
・ Perfume 0.5
・ Product No. 23 8.0
・ Remaining amount of 100 purified water

(Deodorant Mist)
・ Ethanol 30.0
・ Polyoxyethylene hydrogenated castor oil 0.5
・ Benzalkonium chloride 0.1
・ Piroctone Olamine 0.2
・ Aluminum potassium sulfate 5.0
・ Menthol 0.4
・ Perfume 0.5
・ Product No. 4 spray-dried products 1
・ Remaining amount of 100 purified water

(Deodorant stick)
・ Cetanol 5.0
・ Sodium stearate 10.0
・ Isopropyl myristate 10.0
・ Trichlorocarbanilide 0.1
・ Zinc pyrithione 0.1
・ Chlorhydroxyaluminum 15.0
・ Menthol 0.4
・ Fragrance 0.3
・ Product No. 20 10.0
・ Remaining amount of ethanol 100

(Deodorant stick)
Stearyl alcohol 25.0
・ Polyethylene glycol 10.0
・ Triclocarban 0.1
・ Piroctone Olamine 0.2
・ Chlorhydroxyaluminum 20.0
・ Fragrance 0.3
・ Product No. 7 spray-dried products 1
・ Decamethylcyclopentasiloxane 100

(Deodorant gel)
・ Ethanol 60.0
・ Carboxyvinyl polymer 0.4
-Cyclic silicone 1.0
・ Polyether-modified silicone 0.5
・ Triclosan 0.1
・ Isopropylmethylphenol 0.1
・ Benzalkonium chloride 0.1
・ Triethanolamine 0.4
・ Silicone powder 1.0
・ Perfume appropriate amount ・ Product No. 7 10.0
・ Remaining amount of 100 purified water

(Powder spray)
・ Chlorhydroxyaluminum 3.0
・ Silic anhydride 1.5
・ Silicone-treated talc 1.5
・ Zinc oxide 0.5
・ Triclosan 0.05
・ Isopropylmethylphenol 0.1
・ Zinc pyrithione 0.05
・ Isopropyl myristate 2.0
・ Dimethylpolysiloxane 1.0
・ Sorbitan fatty acid ester 0.3
・ Product No. 7 spray-dried products 1
・ Liquefied petroleum gas 100

(Liquid deodorant)
・ Zinc paraphenolsulfonate 2.0
・ Ethanol 30.0
1,3-butylene glycol 3.0
・ Resorcin 0.1
・ Isopropylmethylphenol 0.1
・ Polyoxyethylene (50) hydrogenated castor oil 0.5
・ Perfume appropriate amount ・ Product No. 23 1
・ Remaining amount of 100 purified water

(Deodorant spray)
・ Purified water 30.0
・ Ethanol 20.0
・ Salicylic acid 0.2
・ Isopropylmethylphenol 0.1
・ Product No. 15 1
・ Remaining amount of dimethyl ether 100

(Shampoo composition)
・ Polyquaternium-10 0.8
・ Betaine 0.5
・ Sodium citrate 0.4
・ Lauroylmethylalanine sodium salt 27
・ Cocoyl Methyl Taurine Sodium 8
・ Cocamidopropyl betaine 9
・ Cocamidomethyl MEA 4
・ Lauramide DEA 2
・ Phenoxyethanol 0.8
・ Pentylene glycol 1.5
・ Product No. 24 8
・ Citric acid 0.6
・ Remaining amount of 100 purified water

(Shampoo composition)
-Sodium polyoxyethylene lauryl ether sulfate 8.0
・ Aminopropyl betaine laurate 2.5
・ Polyoxyethylene lauryl ether sodium acetate 1.0
・ Polyoxyethylene sulfosuccinate disodium lauryl 0.5
Palm oil fatty acid diathanolamide 5.0
-O- [2-hydroxy-3- (trimethylammonio) propyl] chloride
Hydroxyethyl cellulose 0.2
・ Leucine 0.02
・ Isoleucine 0.02
・ Dipotassium glycyrrhizinate 0.2
・ Menthol 1.0
・ Product No. 8 10
・ Remaining amount of 100 purified water

(Shampoo composition)
・ Polyoxyethylene lauryl ether sodium sulfate 6.0
・ Lauryldimethylaminoacetic acid betaine 2.0
・ Polyoxyethylene lauryl ether sodium acetate 3.0
-Disodium lauryl sulfosuccinate 1.0
Palm oil fatty acid diathanolamide 5.0
-O- [2-hydroxy-3- (trimethylammonio) propyl] chloride
Guar gum 0.1
・ Arginine 0.01
・ Leucine 0.01
・ Isoleucine 0.01
・ Dipotassium glycyrrhizinate 0.2
・ Menthol 1.0
・ Product No. 24 10
・ Remaining amount of 100 purified water

(Body soap)
・ Product No. 7 spray-dried products
・ Potassium laurate 15
・ Potassium myristate 5
・ Propylene glycol 5
・ Hydrolyzed collagen solution 3
・ Sodium lactate 0.1
・ Residual amount of pH adjustor ・ Pure water 100

(Granule bath preparation)
・ Sodium bicarbonate 60
・ Anhydrous sodium sulfate 30
・ Borax 3
・ Citric acid 2
・ Product No. 7 spray-dried products

  The deodorant and antibacterial agent according to the present invention hardly exhibit skin irritation and exhibit extremely remarkable effects. Therefore, it can be safely used for sensitive skin such as weak skin quality and allergies, and the odor caused by ammonia, acetic acid, iso-valeric acid, 2-nonenal, etc., which causes body odor, is specific and prominent. In addition to deodorizing, it has excellent antibacterial properties against Legionella spp. Therefore, it is extremely excellent in utility as a skin external preparation composition that prevents sweat odor and aging odor while keeping the skin hygienic without adversely affecting the human body or other animals.

Claims (3)

A deodorant for 2-nonenal containing, as an active ingredient, a 60-90% aqueous ethanol extract from the fruit of Rita (Sapindus trifoliatus). The deodorizer according to claim 1, which is used to reduce an aging odor. Odor deodorizing skin external composition containing the deodorant according to any one of claims 1-2.