KR101797727B1 - Mild Cleansing Composition For Ladies - Google Patents

Abstract

The present invention relates to a female detergent composition having excellent antibacterial and deodorant effect. The novel female detergent composition of the present invention is a plant extract containing an acyl lactylate anionic surfactant and saponin and a surfactant as a detergent, comprising a sulfosuccinate type anionic surfactant, an alkyl polyglucoside type nonionic surfactant, an amphoacetate type amphoteric surfactant An activator, and an acyl lactylate-based anionic surfactant.

Description

{Mild Cleansing Composition For Ladies}

The present invention relates to a mild female cleansing composition comprising a natural extract.

There is an ecosystem of lactic acid bacteria species represented by Lactobacillus in the quality of healthy women. Since vagina is a good condition for growth of various microorganisms due to physical position, lactic acid bacteria in vagina produce lactic acid by fermenting glycogen secreted from epithelial cells and produce antimicrobial substances such as hydrogen peroxide and bacteriocin to maintain healthy condition do. Steady-state Lactobacillus present in the vagina acts as a protector to suppress the growth of Gardnerella vaginalis and Escherichia spp., But they are known to exhibit sensitive properties to bactericidal components such as spermicide.

The vaginal microflora are a dynamic system, and even in the quality of healthy women, a small number of pathogenic bacteria are frequently found, and they can multiply more than the Lactobacillus genus. Most of these Lactobacillus spp. Can be replaced by pathogenic Gardnerella vaginalis and aerobic bacteria, which may result in bacterial vaginosis.

The quality of women exposed to diseases such as vaginal bacterias is characterized by the fact that they are not maintained at pH 4.5 by lactic acid secreted by lactic acid bacterium, but are changed to high pH conditions. As a result, microorganisms And it is also a cause of health threat. As a result, efforts are being made to develop alternative therapies instead of existing treatments for vaginal bacteriuria.

These alternative agents are expected to inhibit pathogenic bacteria associated with vaginal bacteria without killing healthy Lactobacillus species, including selective antimicrobial agents, probiotics, and the like. These materials have been studied to be able to reduce the risk of reinfection by other pathogens as they grow healthy Lactobacillus spp.

Among the natural ingredients, lactic acid produced by Lactobacillus sp. Is an easily available antimicrobial ingredient. It maintains a weak acidity of pH 3.8-4.5, which is the condition of pathogenic bacteria. In most cases, it does not cause stimulation of the vaginal mucosa.

Studies on products for the alleviation of vaginal bacteria using lactic acid showed that the products using lactic acid did not show the improvement of perfect vaginal bacteria, but there are some studies that show some degree of alleviation effect in some cases.

In addition, some studies on the natural antibacterial effect of saponin as a component other than the above-mentioned antibacterial component have shown that steroids produced by some plants or marine-derived microorganisms or glycosides of triterpenoids are natural surfactants , It is known that some saponins have antimicrobial activity against gram-positive and gram-negative bacteria and yeast. Saponins from Sapindus mukorossi have also been shown to have no antimicrobial activity against healthy Lactobacillus species.

Saponins are found in many plants and their names are derived from Soapwort plant or Saponaria officinalis and traditionally used the roots as natural soap. Saponins are widely distributed in plants, and plants that can produce large numbers of saponins are named "soap" or "Saponaria" in some parts. Soapwort - Saponaria officinalis, Soaproot - Chloragalum pomeridianum, Soapbark - Saponaria officinalis, Soapnut - Sapindus mukorossi and Jaboncillo - Sapindus saponaria.

Commercially produced saponins are obtained from the continuous extraction step of water and alcohol with quillaja bark or soaproot. The resulting saponin powder is a mixture, not a pure compound, mostly saponin in the form of a trutterpenoid and a glyceride of a trutherpenoid known as saponin. This type of saponin has been used as a surfactant in foam bath products and shampoos. Dermatologically, it is known that saponin extracted from plants is a surfactant that can be used in cleaning products, and there is no evidence that it causes sensitization without inducing primary skin irritation under normal conditions. In addition, some studies have examined the fungicidal effect of vaginal secretions obtained from females suffering from Candida vaginitis with extracts from skin and fat of fruit of Sapindus saponaria L. As a result, water-alcohol solvent extract It has been reported that it exhibits a strong inhibitory effect against C. parasilosis.

In the prescription of conventional human body cleaning products, synthetic surfactants have been mixed to suit the respective characteristics such as foaming property, expansiveness and low unit cost for the purpose of the cleaning effect itself and easy handling. However, recently, there has been a problem of safety to the human body rather than the functionality of these components, so that a new alternative raw material having safety similar to that of the existing raw materials has been actively developed, and efforts have been made to implement it in the prescription .

New raw materials that have priority in the safety of the human body are raw materials obtained from synthesis of natural derived oils and components rather than synthetic components obtained from conventional petroleum. In addition to surfactants used in cleaning streams, there has been a movement in the industry to replace parabens preservatives, which have been controversial in recent years, due to the trends of the past, Triclosan, which is used in the present invention, is also controversial in terms of safety, and new substitutable components have been actively developed.

Korean Patent Registration No. 1087734 discloses a cosmetic composition for hair using a crude saponin extract obtained by using various organic solvents from a mushroom tree, as an example of applying plant saponin to a cosmetic product by refining it.

Korean Patent Laid-Open Publication No. 2010-0104625 discloses a method for producing a herbal composition for local cleansing of women including gosam, acne, peony, and red ginseng as an example of application of a plant extract showing antibacterial effect to a female cleaner.

Accordingly, the inventors of the present invention have solved the problem that the sterilization and antimicrobial components used in the conventional female cleanser compositions have a sterilizing effect against harmful bacteria related to diseases, but they also kill the normal skin bacteria that protect the body like lactic acid bacteria Thus completing the present invention. The present invention relates to a novel antibacterial raw material which has antibacterial and deodorizing effect or can be applied in place of conventional synthetic surfactant, and as a result, it is possible to obtain a novel antibacterial raw material which exhibits excellent antibacterial effect, A female cleaner composition was developed.

The object of the present invention is achieved by a female detergent cleaning composition having an antibacterial and deodorizing effect comprising a plant extract containing an acyl lactylate anionic surfactant and saponin.

Preferably, the acyl lactylate anionic surfactant is sodium isostearoyl lactylate, sodium caproyl lactylate, sodium lauroyl lactylate or a mixture thereof.

Preferably, the plant extract comprising saponin is a phyt foam, a soap nut powder or a mixture thereof.

In addition, the female cleaner composition having an antibacterial and deodorizing effect according to the present invention further comprises a sulfosuccinate type anionic surfactant, an alkyl polyglucoside type nonionic surfactant and a amphoacetate type amphoteric surfactant as cleaning components.

Preferably, the sulfosuccinate type anionic surfactant is disodium laureth sulfosuccinate.

Preferably, the alkyl polyglucoside-based nonionic surfactant is decyl glucoside or coco glucoside.

Preferably, the amphoacetate ampholytic surfactant is disodium cocoamphoacetate.

Preferably, the composition comprises 0.01 to 5% by weight of an acyl lactate-based anionic surfactant based on the total weight of the composition, and 0.01 to 30% by weight of a plant extract containing saponin. 5 to 90% by weight of a sulfosuccinate type anionic surfactant, 4 to 30% by weight of an alkyl polyglucoside type nonionic surfactant and 4 to 30% by weight of a amphoacetate type amphoteric surfactant.

The mild female cleanser composition according to the present invention exhibits a selective antibacterial effect while exhibiting good cleaning ability and less skin irritation. Especially, the sterilizing and antibacterial components exhibit a sterilizing effect against harmful bacteria related to diseases, and they do not have antimicrobial activity against normal skin bacteria that protect the body like lactic acid bacteria.

The present invention relates to a female detergent composition having antibacterial and deodorant effect, which comprises an acyl lactylate anionic surfactant and a plant extract containing saponin.

Plant extracts containing the saponin component applied to the present invention can be obtained by extracting Acacia Concinna Fruit Extract, Balanites It uses the Aegyptiaca (Desert Date) Fruit Extract, Gypsophila Paniculata Root Extract form the pitot (PHYTOFOAM ™, CRODA) or INCI name Sapindus Mukorossi the sopneot powder (Soapnut powder, VIVIMED). These may be used alone or in combination.

The female cleaner composition of the present invention contains an acyl lactylate anionic surfactant as an essential component.

Among the nonionic surfactants used in the female cleaners, the cationic alkylamides and dialkamamides, which are INCI names added to enhance the stability of the foam, are Cocamide DEA, which are excellent in water solubility and inexpensiveness and have a sulfate anionic surfactant Has an advantage of exhibiting an excellent accumulating ability when used, but it is a component having a safety-related problem such as being recently designated as a prohibited ingredient in some countries due to the secondary amine content of carcinogen.

Accordingly, the present inventors have investigated an acyl lactylate anionic surfactant as a component capable of enhancing the porosity, bubble stability, and moisturizing properties of mildew on the skin and mucous membrane in place of Cocamide DEA, and applied the composition of the present invention. An acyl lactylate anionic surfactant is a component which is combined with an alpha hydroxy acid and a fatty acid, and is a component which does not stimulate the eye unlike the alpha hydroxy acid. In addition, both alpha hydroxy acids and fatty acids correspond to components of the NMF (Natural Moisturizing Factor), a component of the skin surface. This ingredient is divided into various kinds according to the number of carbon atoms (C6 to C22) of the fatty acid of the acyl group and is mainly used as a foam strengthening agent and solubilizing agent.

The present invention is based on the application of sodium isostearoyl lactylate (INCI) among the acyl lactylate anionic surfactants. This ingredient is a raw material known to have excellent porosity and foam stability when used together with amphoteric surfactant, cocamidopropyl betaine or alkyl polyglucoside as the main surfactant. In the present invention, Pationic ISL (RITA) was preferably used.

Among the acyl lactylate salts, surfactants whose INCI name is sodium caproyl lactylate or sodium lauroyl lactylate are known to exhibit antibacterial effects against various bacteria or fungi. In the present invention, Dermosoft ™ decalact liquid, which is sodium caproyl / lauroyl lactyl lactate and triethyl citrate, was used as a raw material for INCI.

Surfactants are classified as (1) cation (2) anion (3) nonionic (4) amphoteric surfactant depending on their physical properties, and they have various interfacial characteristics depending on their chemical composition and structure. Among them, the main surfactant (detergent) used in the cleaning product is used in an appropriate ratio in accordance with the characteristics thereof. Among these, anionic surfactants are used as main surfactants and have excellent bubble and cleaning ability. Amphoteric surfactants are stabilized and stimulated by mixing with mild foaming power and anionic surfactant as auxiliary surfactants. And the nonionic surfactant is characterized by the role of foam boosting and maximizing the incremental effect.

However, since the cleaned product is not stiff after use, it is necessary to mix various kinds of raw materials in order to obtain a good feeling of use. Considering the market position of the cleaned product, the product should be washed at a low cost. It is common to use sulfate anionic synthetic surfactant as a main surfactant, which causes irritation to the eyes and mucous membranes but has excellent foaming power.

In addition to the plant extract containing the acyl lactylate anion surfactant and saponin as described above, the present invention provides a composition comprising a sulfosuccinate type anionic surfactant, an alkyl polyglucoside type nonionic surfactant, and an amphoacetate type amphoteric surfactant Further comprising an activator.

In this case, the composition preferably comprises 5 to 90% by weight of a sulfosuccinate type anionic surfactant, 4 to 30% by weight of an alkyl polyglucoside type nonionic surfactant, 4 to 30% by weight of a amphoacetate type amphoteric surfactant, 0.01 to 5% by weight of an acyl lactylate anionic surfactant, and 0.01 to 30% by weight of a plant extract containing saponin.

The sulfosuccinate type anionic surfactant may be preferably disodium laureth sulfosuccinate.

Among the products developed as anionic surfactants, the component known as DISODIUM LAURETH SULFOSUCCINATE by INCI name is a slightly higher unit price than an amino acid surfactant but a sulfate anionic surfactant, but the amino acid succinic acid As a result, the inventors found that the alkyl ester synthesized by the present invention exhibited a relatively low foaming power with little irritation and was applied to the female cleaner of the present invention.

In addition, a prescription was made using Alkylpolyglucosides (APG), an alkylpolyglucoside type surfactant, INCI name DECYL GLUCOSIDE, instead of a sulfate anionic surfactant as a mild synthetic surfactant on the skin.

In the above, amphoacetate ampholytic surfactant may preferably be disodium cocoamphoacetate.

Disodium cocoamphoacetate is a representative amphoteric surfactant. Amphoteric surfactants contain both acidic and basic groups in one molecule. Depending on the nature of the aqueous solution, they can lose or add both to maintain their anionic, cationic or nonionic form . Because of this property, it can be mixed with all kinds of surfactants, and it has a great effect because it contains a high concentration of electrolyte or dissolves in an acidic or basic solution. Amphoteric surfactants are primarily used as cosurfactants because of their low irritancy when used with foam stabilization, thickening, alkyl sulfates or alkyl ethoxy sulfates. Amphoteric surfactants are also commonly used as primary surfactants in bay bean shampoos due to their very low skin and mucosal irritation properties compared to other types of surfactants.

In the present invention, it has been found that the above-mentioned ingredients can perform similar or superior functions by replacing the components of the existing prescription, and a new prescription is formed and its performance is confirmed.

Other objects and advantages of the present invention will become more apparent from the following detailed description and claims. Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood by those skilled in the art that these embodiments are only for describing the present invention in more detail and that the scope of the present invention is not limited by these embodiments in accordance with the gist of the present invention .

Example

1. Selection of antibacterial plant extracts and new antibacterial raw materials

In order to prepare a female detergent composition comprising the plant-derived saponin component according to the present invention, PHYTOFOAM (TM), a raw material containing saponin known to have antimicrobial effect mentioned in the data or papers obtained from each raw material manufacturer The antimicrobial activity of Soapnut powder (VIVIMED), Pationic ISL (RITA) and Dermosoftdecalact liquid was measured by the paper disk method. The INCI names of the above materials are shown in Table 1 below.

The antimicrobial activity of the antimicrobial agent was measured by measuring the size of the clear zone around the disk after placing the microplate on a paper disk impregnated with the sample solution containing the antimicrobial substance.

The strains used in the test are Gardnerella vaginalis ( KCTC5096), Prevotella bivia (KCTC 5322), anaerobic gram-negative bacteria which are known to cause vaginitis in women's vagina, Peptostreptococcus anaerobius (KCTC 5973) and yeast Candida albicans (KCTC 7965), which are positive strains , were used. Lactobacillus acidophilus ( Lactobacillus acidophilus KCTC 3151) was also used as a beneficial strain to create a weakly acidic environment in female vaginal epithelium. The anaerobic bacteria were cultivated in thioglycollate broth medium (Hanil Chemad, Korea) at 37 ° C for 1 to 2 days, Candida albicans were cultivated in Sabouraud dextrose broth (Difco, USA) at 30 ° C for 1-2 days, Were prepared.

50 μl of a sample to be tested for antibacterial activity is soaked in a paper disk (diameter: 8 mm, thickness: 1.5 mm) and allowed to stand at room temperature for one day. The prepared bacteria were measured to be 1 × 10 ⁶ CFU after measuring the absorbance, and then anaerobes were analyzed for Brucella agar, Lactobacillus acidophilus for MRS Agar (Difco, USA), Candida albicans for the microorganisms on a Potato dextrose agar medium . After the paper disc is pre-moistened with the sample on the medium, the bacteria are anaerobically cultured in an anaerobic jar at 37 ° C for 3 to 4 days using a gas pack system (Merck, anaerocult gaspack system, Germany). Candida albicans should be cultivated at 30 ° C for 2-3 days. After culturing, the antibacterial activity was confirmed by measuring the diameter of the transparent ring which did not grow bacteria around the paper disk. The measured antimicrobial activities are shown in Table 2 below.

(PHYTOFOAM ™, CRODA), soap powder (Soapnut powder, VIVIMED), which is a raw material containing saponin, and an acyl lactylate-based raw material Pationic® ISL ™, and RITA), dermosoftdecalact liquid, and the antimicrobial effect of the four raw materials of the dermosoftdecalact liquid was confirmed by the single and mixed conditions. Respectively.

Especially, it was confirmed that when four kinds were mixed, they exhibited excellent antimicrobial effect against various harmful bacteria and did not show antibacterial effect against lactic acid bacteria which are useful bacteria.

2. Manufacture of female cleaners

From the results of the antimicrobial effect measurement for each bacterium obtained in Table 2, the female cleaners of Examples 1 to 4 having the compositions shown in Table 3 below were prepared.

As a comparative example, one kind or two kinds of the raw materials each having the antibacterial activity confirmed were prepared as shown in Table 4 below, and the antibacterial activity was compared.

Experimental Example

1. Antimicrobial activity test (paper disk method)

The antibacterial activity of the female cleaners of Examples and Comparative Examples was evaluated by measuring the size of the growth inhibition rings by the paper disk method in the same manner as in the antibacterial activity test method of the above Examples, and the results are shown in Table 5 below.

The cosmetic compositions of Examples 1 to 4 of the present invention were found to have excellent antimicrobial activity against pathogenic noxious bacteria and odor-causing strains. In particular, the antimicrobial effect against Corynebacterium, which is an odor-inducing strain, I think. In addition, it does not show antibacterial activity against lactic acid bacterium, which is a beneficial organism of human body, and has an advantage of not hindering the homeostasis of the human body due to long-term use of the antibacterial ingredient.

2. Bubble strength and bubble stability test

The bubble strength and the stability of the bubbles were measured at a temperature of 40 ° C. for 1 wt% aqueous solution using the Ross-Miles method using the apparatus specified by ASTM D 1173-63. The measurement method was a vertical And the temperature was kept constant by circulating water at 40 ° C to the outer surface. Then, 50 ml of the test solution was carefully flowed down along the inner wall of the measuring apparatus, and 200 ml of the same test liquid was filled into a foam pipet. The height (cm) of the bubbles caused by falling into the position was measured as the initial height and the latter height (height after 5 minutes). The bubble strength and bubble stability measurement results are shown in Table 6 below.

The cosmetic compositions of Examples 1 to 3 of the present invention were comparable to those of Comparative Examples 4 to 6, which were increased using conventional sodium laureth sulfate and cocamide dielite and superior in bubble power and bubble retention Similar results showed excellent foam strength and bubble retention.

3. Skin patch test (skin irritation confirmation test)

In order to compare the skin irritation of the cosmetic compositions of Examples 1 to 3, the evaluation of the closure pellet against skin irritation was carried out using the cosmetic compositions of Comparative Examples 1 to 6.

(1% concentration) of the examples and the comparative examples were adhered to the lower limbs of both arms for 24 hours and removed to check skin irritation. The results of this experiment are shown in Table 7 below

From the results of the experiment shown in Table 7, it can be seen that the female cleaner composition according to the embodiment of the present invention is relatively less irritating than the conventional female cleaner.

Claims (8)

As a female cleansing composition having an antibacterial and deodorizing effect,
An acyl lactylate anionic surfactant and a saponin-containing plant extract,
Wherein the acyl lactylate anionic surfactant is sodium isostearoyl lactylate, sodium caproyl lactylate, sodium lauroyl lactylate, or a mixture thereof. The female detergent composition according to claim 1, wherein the saponin-containing plant extract is a phyt foam, a soap powder, or a mixture thereof. The composition according to claim 1 or 2, wherein the composition further comprises a sulfosuccinate type anionic surfactant, an alkyl polyglucoside type nonionic surfactant, and a amphoacetate type amphoteric surfactant as a cleaning component And a deodorant effect. The female detergent composition according to claim 3, wherein the sulfosuccinate-based anionic surfactant is disodium laureth sulfosuccinate. 4. The composition according to claim 3, wherein the alkyl polyglucoside-based nonionic surfactant is decyl glucoside or coco glucoside. 4. The composition according to claim 3, wherein the amphoacetate ampholytic surfactant is disodium cocoamphoacetate. 4. The method of claim 3, wherein the female detergent composition comprises 0.01 to 5% by weight of an acyl lactate anionic surfactant, 0.01 to 30% by weight of a plant extract containing saponin, a sulfosuccinate anionic surfactant, By weight of an alkylpolyglucoside-based nonionic surfactant, 4 to 30% by weight of an alkyl polyglucoside-based nonionic surfactant and 4 to 30% by weight of a amphoacetate-based amphoteric surfactant. delete