CN113509414A - Antibacterial and anti-inflammatory shower gel and preparation method thereof - Google Patents

Antibacterial and anti-inflammatory shower gel and preparation method thereof Download PDF

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Publication number
CN113509414A
CN113509414A CN202110674314.XA CN202110674314A CN113509414A CN 113509414 A CN113509414 A CN 113509414A CN 202110674314 A CN202110674314 A CN 202110674314A CN 113509414 A CN113509414 A CN 113509414A
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antibacterial
surfactant
phase
inflammatory
shower gel
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王颖
付青
黄亿之
毛勇进
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Guangdong Jingcui Biotechnology Co ltd
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Guangdong Jingcui Biotechnology Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005Antimicrobial preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/10Washing or bathing preparations

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  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Cosmetics (AREA)

Abstract

The invention relates to the technical field of cosmetics, in particular to an antibacterial and anti-inflammatory shower gel and a preparation method thereof. The raw materials comprise the following components in percentage by weight: phase A: 20-50% of larch extract, 2-20% of surfactant, 0.1-2% of hydantoin derivative, 0.01-2% of organic acid, 0.01-0.1% of synergist and 0.1-5% of excipient; phase B: 0.01-1% of alkali, 0.02-2% of glycerol derivative, 0.1-1% of antioxidant and the balance of water. The shower gel disclosed by the invention can efficiently clean skin, and the skin is fresh and comfortable after use and does not have uncomfortable feeling of dryness and tightness; has antibacterial and anti-inflammatory effects, and can improve skin pruritus and scale; meanwhile, the skin care lotion is mild and non-irritant to the skin, and can condition and moisten the skin; the shower gel has strong stability and can be stably stored at the temperature of-4-50 ℃; the shower gel has the advantages of environment-friendly and safe raw materials, simple and convenient process, strong practicability and wide application prospect.

Description

Antibacterial and anti-inflammatory shower gel and preparation method thereof
Technical Field
The invention relates to the technical field of cosmetics, in particular to an antibacterial and anti-inflammatory shower gel and a preparation method thereof.
Background
With the improvement of national economy and living standard, consumers put higher demands on the quality and performance of daily chemical products. The soap is used as a traditional washing article, can effectively remove grease dirt on the surface of human skin, and is a daily necessity for every family. However, the toilet soap inevitably combines with skin stratum corneum substances while playing a role in cleaning effectively, interferes with the water retention mechanism of keratinized skin, leads stratum corneum cells to be easy to denature, and the skin is easy to have the defects of dryness, desquamation, scale and the like, and is rougher after long-term use. The shower gel is used as a novel liquid cleanser, the skin is cleaned by the combined action of the components such as the surfactant, the foam booster, the pH regulator and the like, the pH value is usually in a neutral range, the shower gel has the advantages of excellent cleaning power and mild low stimulation, the skin inner layer can be cared while the skin is washed, the skin feeling of a consumer after bathing is comfortable and smooth, and the shower gel is gradually favored by the market.
Chinese patent CN201811001219.8 discloses a moisturizing bath lotion, which is prepared by biologically extracting aloe, tea and ilex pubescens bark through microbial fermentation, and is beneficial to astringing skin pores, and the moisturizing effect of the bath lotion is improved. However, the invention needs to be put into fermentation tank equipment for extracting plant components, and also needs specific magnetized water treatment, has extremely high requirements on the stability of raw materials and processes, and is not suitable for large-scale batch production. Based on the above, the problem to be solved in the field is to explore the shower gel which has the advantages of easily available raw materials, simple and convenient process and cleaning, bacteriostasis and skin care effects.
Disclosure of Invention
The invention provides the antibacterial and anti-inflammatory bath lotion, solves the problems of single function, complex raw material process and poor practicability of the bath lotion in the prior art, and realizes the bath lotion which has the advantages of easily available raw materials, simple and convenient process and cleaning, antibacterial and skin-care effects.
The invention provides an antibacterial and anti-inflammatory bath lotion, which comprises the following raw materials in percentage by weight:
phase A: 20-50% of larch extract, 2-20% of surfactant, 0.1-2% of hydantoin derivative, 0.01-2% of organic acid, 0.01-0.1% of synergist and 0.1-5% of excipient;
phase B: 0.01-1% of alkali, 0.02-2% of glycerol derivative, 0.1-1% of antioxidant and the balance of water;
the sum of the weight ratios of the phase A and the phase B is 100 percent.
In a preferred embodiment, the deciduous tree comprises at least one of soapberry, magnolia, ligustrum lucidum, elm, linden, birch, liriodendron, chongyang wood, jacaranda, guava.
In a preferred embodiment, the surfactant is selected from at least 2 of cationic surfactants, anionic surfactants, zwitterionic surfactants, and nonionic surfactants.
In a preferred embodiment, the surfactants are anionic, zwitterionic and nonionic surfactants.
In a preferred embodiment, the weight ratio of the anionic surfactant, zwitterionic surfactant and nonionic surfactant is (1-5): (3-8): (0.1-3).
In a preferred embodiment, the hydantoin derivative comprises at least one of 5-p-hydroxyphenylhydantoin, 5-methyl-5-ethylhydantoin, 5, 5-dimethylhydantoin, 5-ureidohydantoin.
In a preferred embodiment, the organic acid has a melting point of 150-163 ℃ and a surface tension of 60-70 dyne/cm.
In a preferred embodiment, the synergist comprises at least one of a polyphosphate, an aminocarboxylic acid and its salt, a 1, 3-diketone, a hydroxycarboxylic acid, and a polyamine.
The invention provides a preparation method of antibacterial and anti-inflammatory shower gel, which comprises the following specific preparation steps:
s1, weighing and mixing the phase A raw materials according to the formula ratio, heating to 70-85 ℃, and uniformly stirring to obtain a mixture I;
s2, cooling the mixture I to 35-48 ℃, adding the phase B raw material, uniformly stirring, and cooling to obtain a finished product.
In a preferred embodiment, in the step S2, the operation of adding the phase B raw material specifically comprises: adding alkali, stirring, keeping stirring, and adding glycerol derivative, antioxidant and water.
Has the advantages that:
the shower gel obtained by the invention has the following advantages:
(1) the shower gel can efficiently clean skin, and the skin is fresh and comfortable after use without uncomfortable feeling of dryness and tightness;
(2) the bath lotion has antibacterial and anti-inflammatory effects, and can improve skin pruritus and scale; meanwhile, the skin care lotion is mild and non-irritant to the skin, and can condition and moisten the skin;
(3) the shower gel has strong stability, can be stably stored at the temperature of between 4 ℃ below zero and 50 ℃, is not easy to generate the phenomena of layering, turbidity, color change and peculiar smell, and has wide temperature resistance and stable property;
(4) the shower gel has the advantages of environment-friendly and safe raw materials, simple and convenient process, strong practicability and wide application prospect, and can meet the product standard requirements of the shower gel industry.
Detailed Description
The disclosure may be understood more readily by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, including definitions, will control.
The term "prepared from …" as used herein is synonymous with "comprising". The terms "comprises," "comprising," "includes," "including," "has," "having," "contains," "containing," or any other variation thereof, as used herein, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.
The conjunction "consisting of …" excludes any unspecified elements, steps or components. If used in a claim, the phrase is intended to claim as closed, meaning that it does not contain materials other than those described, except for the conventional impurities associated therewith. When the phrase "consisting of …" appears in a clause of the subject matter of the claims rather than immediately after the subject matter, it defines only the elements described in the clause; other elements are not excluded from the claims as a whole.
When an amount, concentration, or other value or parameter is expressed as a range, preferred range, or as a range of upper preferable values and lower preferable values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value and any lower range limit or preferred value, regardless of whether ranges are separately disclosed. For example, when a range of "1 to 5" is disclosed, the described range should be interpreted to include the ranges "1 to 4", "1 to 3", "1 to 2 and 4 to 5", "1 to 3 and 5", and the like. When a range of values is described herein, unless otherwise stated, the range is intended to include the endpoints thereof and all integers and fractions within the range.
The singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise. "optional" or "any" means that the subsequently described event or events may or may not occur, and that the description includes instances where the event occurs and instances where it does not.
Approximating language, as used herein throughout the specification and claims, is intended to modify a quantity, such that the invention is not limited to the specific quantity, but includes portions that are literally received for modification without substantial change in the basic function to which the invention is related. Accordingly, the use of "about" to modify a numerical value means that the invention is not limited to the precise value. In some instances, the approximating language may correspond to the precision of an instrument for measuring the value. In the present description and claims, range limitations may be combined and/or interchanged, including all sub-ranges contained therein if not otherwise stated.
In addition, the indefinite articles "a" and "an" preceding an element or component of the invention are not intended to limit the number requirement (i.e., the number of occurrences) of the element or component. Thus, "a" or "an" should be read to include one or at least one, and the singular form of an element or component also includes the plural unless the stated number clearly indicates that the singular form is intended.
"Polymer" means a polymeric compound prepared by polymerizing monomers of the same or different types. The generic term "polymer" embraces the terms "homopolymer", "copolymer", "terpolymer" and "interpolymer". "interpolymer" means a polymer prepared by polymerizing at least two different monomers. The generic term "interpolymer" includes the term "copolymer" (which is generally used to refer to polymers prepared from two different monomers) and the term "terpolymer" (which is generally used to refer to polymers prepared from three different monomers). It also includes polymers made by polymerizing more monomers. "blend" means a polymer formed by two or more polymers being mixed together by physical or chemical means.
In order to solve the problems, the invention provides an antibacterial and anti-inflammatory bath lotion in a first aspect, which comprises the following raw materials in percentage by weight:
phase A: 20-50% of larch extract, 2-20% of surfactant, 0.1-2% of hydantoin derivative, 0.01-2% of organic acid, 0.01-0.1% of synergist and 0.1-5% of excipient;
phase B: 0.01-1% of alkali, 0.02-2% of glycerol derivative, 0.1-1% of antioxidant and the balance of water;
the sum of the weight ratios of the phase A and the phase B is 100 percent.
Further preferably, the raw materials comprise, by weight:
phase A: 25-45% of larch extract, 4-16% of surfactant, 0.2-1% of hydantoin derivative, 0.03-1% of organic acid, 0.04-0.1% of synergist and 0.3-3% of excipient;
phase B: 0.1-1% of alkali, 0.05-1% of glycerol derivative, 0.1-0.5% of antioxidant and the balance of water;
the sum of the weight ratios of the phase A and the phase B is 100 percent.
In some preferred embodiments, the deciduous tree comprises at least one of soapberry, magnolia, ligustrum lucidum, elm, linden, birch, tulip, chow, albizzia, jacaranda, guava.
Further preferably, the deciduous arbor extract is a soapberry pericarp extract.
In some preferred embodiments, the surfactant is selected from at least 2 of cationic surfactants, anionic surfactants, zwitterionic surfactants, and nonionic surfactants.
Further preferably, the surfactant is an anionic surfactant, a zwitterionic surfactant and a nonionic surfactant.
Still more preferably, the weight ratio of the anionic surfactant, the zwitterionic surfactant and the nonionic surfactant is (1-5): (3-8): (0.1-3).
In some preferred embodiments, the zwitterionic surfactant is at least one of lecithin, a betaine derivative, an imidazoline compound, an alkylamine oxide, and a carboxylate.
In some preferred embodiments, the zwitterionic surfactant is a betaine derivative and an imidazoline compound.
In some preferred embodiments, the betaine derivative is at least one of an alkyldimethyl betaine, a dodecylethoxysulphobetaine, a dodecylhydroxypropylsulphobetaine, a dodecylsulfopropyl betaine, a tetradecamidopropylhydroxypropylsulphobetaine, a decylhydroxypropylsulphobetaine, a cocamidopropylbetaine, a phospholipidbetaine.
As examples of betaine derivatives, there are included, but not limited to, cocamidopropyl betaine.
As an example of an imidazoline compound, there is included, but not limited to, disodium cocoamphodiacetate.
In some preferred embodiments, the anionic surfactant is at least one of an N-acyl amino acid salt, a fatty alcohol sulfate, a sulfoarylsulfonate, an anionic polyacrylamide, a fatty acid sulfoalkyl ester.
In some preferred embodiments, the N-acyl amino acid salt is at least one of cocoyl sarcosinate, cocoyl sarcosinate TEA, lauroyl sarcosinate and salts thereof, myristoyl sarcosinate, palmitoyl sarcosinate, oleoyl sarcosinate, lauroyl methylaminopropionate.
Further preferably, the N-acyl amino acid salt is sodium lauroyl sarcosinate.
In some preferred embodiments, the nonionic surfactant is at least one of polyoxyethylene alkylolamides, polyoxyethylene alkylamines, polyoxyethylene fatty acid esters, alkylphenol ethoxylates, long-chain fatty alcohol ethers, polyoxypropylene-polyoxyethylene copolymers, alkanolamides.
Further preferably, the nonionic surfactant is an alkanolamide.
As an example of an alkanolamide, there is included, but not limited to, cocoyl monoethanolamine.
In some preferred embodiments, the hydantoin derivative comprises at least one of 5-p-hydroxyphenylhydantoin, 5-methyl-5-ethylhydantoin, 5, 5-dimethylhydantoin, and 5-ureidohydantoin.
Further preferably, the hydantoin derivative is 5-ureidohydantoin.
In some preferred embodiments, the organic acid has a melting point of 150-163 ℃ and a surface tension of 60-70 dyne/cm.
More preferably, the organic acid is salicylic acid, the melting point of the salicylic acid is 159 ℃, and the surface tension of the salicylic acid is 64.4 dyne/cm.
In some preferred embodiments, the synergist comprises at least one of polyphosphates, aminocarboxylic acids and their salts, 1, 3-diketones, hydroxycarboxylic acids, polyamines.
More preferably, the synergist is an aminocarboxylic acid or a salt thereof.
Examples of aminocarboxylic acids and their salts include, but are not limited to, disodium edetate.
In some preferred embodiments, the excipient comprises at least one of an acrylate polymer, petrolatum, gum, polysaccharide.
In some preferred embodiments, the glycerol derivative comprises at least one of a glycerol fatty acid ester, a glycerol trinitrate, a glycerol ether, an alkoxyglycerol.
Further preferably, the glycerol derivative is an alkoxyglycerol.
As an example of alkoxyglycerol, but not limited to, ethylhexyl glycerol is included.
In some preferred embodiments, the antioxidant comprises at least one of sodium benzoate, potassium sorbate, sodium dehydroacetate, sodium diacetate, calcium propionate, phenol etherate.
More preferably, the antioxidant is a phenol etherate.
Examples of phenol etherates include, but are not limited to, ethylene glycol phenyl ether.
In some preferred embodiments, the base comprises sodium hydroxide and/or potassium hydroxide.
According to the shower gel, the deciduous tree extract is added into the shower gel, and the foaming capacity of the shower gel in the using process can be improved under the synergistic effect of the surfactant. Especially, when the deciduous tree extract is the soapberry pericarp extract, the shower gel can generate a large amount of dense foam and can effectively resist bacteria and diminish inflammation. The reasons may be that the soapberry peel extract contains rich glycoside substances, wherein the triterpenoid saponin and sesquiterpene glycoside compounds contain small molecular polar groups, can block the protein expression of microorganisms and inhibit the normal physiological activities of the microorganisms, and can greatly relieve the skin itching after bathing by using the shower gel containing the soapberry peel extract so as to keep the skin fresh and comfortable.
The inventor further finds that the anionic surfactant, the zwitterionic surfactant and the nonionic surfactant act together, and particularly the weight ratio of the anionic surfactant, the zwitterionic surfactant and the nonionic surfactant is (1-5): (3-8): (0.1-3), the foaming effect of the shower gel can be further improved; the saponin compound in the soapberry peel extract and the hydrophilic group in the surfactant act together, the hydrophilic group and the hydrophilic oil group are combined with the water phase and the oil phase respectively to form an oriented and ordered interface layer, the surface tension of an air-water interface is reduced remarkably, fine bubbles are formed after air is contacted with shower gel, the bubbles float and gather to form a foam layer, and the foam layer acts on the skin to effectively remove the dirt on the surface of the skin.
The traditional shower gel is sensitive to environmental change due to complex components, and the specific selection of the components of the shower gel is found in the invention, so that the stability of the shower gel can be further improved. The inventor unexpectedly finds that when the organic acid with the melting point of 150-163 ℃ and the surface tension of 60-70dyne/cm is adopted, on one hand, the organic acid can promote the shower gel to permeate into pores to clean the skin, dissolve structural substances of skin superficial cutin, promote thicker cutin to fall off to form new tissues, and achieve the skin moistening effects of skin rejuvenation, fine line fading and the like; on the other hand, the compatibility of the raw materials such as a surfactant, a deciduous tree extract, a hydantoin derivative and the like can be improved, so that the shower gel is stored in a stable state at the temperature of between 4 ℃ below zero and 50 ℃, and the phenomena of layering and precipitation are not easy to occur. The inventor also unexpectedly finds that when the phase A and the phase B are mixed, the alkali is added firstly, and then the glycerin derivative, the antioxidant and the water are added into the system and uniformly mixed, so that the foaming amount of the shower gel can reach more than 180mm, the obtained shower gel has excellent skin-friendly performance, the dryness and tightness of the skin after use are obviously improved, the hydration capability of the skin cuticle is improved, and the skin is in a smooth, elastic and moist state after use.
The invention provides a preparation method of antibacterial and anti-inflammatory shower gel, which comprises the following specific preparation steps:
s1, weighing and mixing the phase A raw materials according to the formula ratio, heating to 70-85 ℃, and uniformly stirring to obtain a mixture I;
s2, cooling the mixture I to 35-48 ℃, adding the phase B raw material, uniformly stirring, and cooling to obtain a finished product.
In some preferred embodiments, in the step S2, the operation of adding the phase B raw material specifically comprises: adding alkali, stirring, keeping stirring, and adding glycerol derivative, antioxidant and water.
Examples
In order to better understand the above technical solutions, the following detailed descriptions will be provided with reference to specific embodiments. It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention. In addition, the raw materials are commercially available and the extraction methods of the extract are all conventional extraction methods, if not otherwise specified.
Example 1.
The embodiment provides an antibacterial and anti-inflammatory bath lotion which comprises the following raw materials in percentage by weight:
phase A: 35% of deciduous tree extract, 13% of surfactant, 0.5% of hydantoin derivative, 0.5% of organic acid, 0.08% of synergist and 1% of excipient;
phase B: 0.3% of alkali, 0.5% of glycerol derivative, 0.3% of antioxidant and the balance of water;
the sum of the weight ratios of the phase A and the phase B is 100 percent.
The deciduous arbor extract is a soapberry pericarp extract and is purchased from Guangdong cyanine extraction Biotech limited; the INSI of the Sapindus MUKOROSSI PEEL EXTRACT is Sapindus MUKOROSSI PEEL EXTRACT.
The surfactant is an anionic surfactant, a zwitterionic surfactant and a nonionic surfactant; the weight ratio of the anionic surfactant, the zwitterionic surfactant and the nonionic surfactant is 3: 6: 1.5.
the anionic surfactant is sodium lauroyl sarcosinate (CAS number 137-16-6); the zwitterionic surfactant is cocoamidopropyl betaine (CAS number is 83138-08-3) and disodium cocoyl amphodiacetate (CAS number is 68650-39-5), and the weight ratio of the cocoamidopropyl betaine to the disodium cocoyl amphodiacetate is 1: 1; the nonionic surfactant is cocoyl monoethanolamine (CAS number 68140-00-1).
The hydantoin derivative is 5-ureidohydantoin with a CAS number of 97-59-6.
The organic acid is salicylic acid (CAS number is 69-72-7), the melting point of the salicylic acid is 159 ℃, and the surface tension of the salicylic acid is 64.4 dyne/cm.
The synergist is aminocarboxylic acid and salt thereof, specifically disodium ethylene diamine tetraacetate with CAS number of 139-33-3.
The excipient is an acrylate polymer, and Wuhan Zeshan Daihn Biopharmaceutical technology GmbH.
The alkali is sodium hydroxide; the glycerol derivative is ethylhexyl glycerol with CAS number 70445-33-9, the antioxidant is ethylene glycol phenyl ether with CAS number 122-99-6.
The antibacterial and anti-inflammatory shower gel comprises the following specific preparation steps:
s1, weighing and mixing the phase A raw materials according to the formula ratio, heating to 80 ℃, and uniformly stirring to obtain a mixture I;
s2, cooling the mixture I to 45 ℃, adding alkali, uniformly stirring, keeping stirring, adding the glycerol derivative, the antioxidant and the water, uniformly stirring, and cooling to obtain a finished product.
Example 2.
The embodiment provides an antibacterial and anti-inflammatory bath lotion which comprises the following raw materials in percentage by weight:
phase A: 25% of deciduous tree extract, 6% of surfactant, 0.3% of hydantoin derivative, 0.2% of organic acid, 0.04% of synergist and 0.5% of excipient;
phase B: 0.1% of alkali, 0.3% of glycerol derivative, 0.3% of antioxidant and the balance of water;
the sum of the weight ratios of the phase A and the phase B is 100 percent.
The deciduous arbor extract is a soapberry pericarp extract and is purchased from Guangdong cyanine extraction Biotech limited; the INSI of the Sapindus MUKOROSSI PEEL EXTRACT is Sapindus MUKOROSSI PEEL EXTRACT.
The surfactant is an anionic surfactant, a zwitterionic surfactant and a nonionic surfactant; the weight ratio of the anionic surfactant, the zwitterionic surfactant and the nonionic surfactant is 3: 6: 1.5.
the anionic surfactant is sodium lauroyl sarcosinate (CAS number 137-16-6); the zwitterionic surfactant is cocoamidopropyl betaine (CAS number is 83138-08-3) and disodium cocoyl amphodiacetate (CAS number is 68650-39-5), and the weight ratio of the cocoamidopropyl betaine to the disodium cocoyl amphodiacetate is 1: 1; the nonionic surfactant is cocoyl monoethanolamine (CAS number 68140-00-1).
The hydantoin derivative is 5-ureidohydantoin with a CAS number of 97-59-6.
The organic acid is salicylic acid (CAS number is 69-72-7), the melting point of the salicylic acid is 159 ℃, and the surface tension of the salicylic acid is 64.4 dyne/cm.
The synergist is aminocarboxylic acid and salt thereof, specifically disodium ethylene diamine tetraacetate with CAS number of 139-33-3.
The excipient is an acrylate polymer, and Wuhan Zeshan Daihn Biopharmaceutical technology GmbH.
The alkali is sodium hydroxide; the glycerol derivative is ethylhexyl glycerol with CAS number 70445-33-9, the antioxidant is ethylene glycol phenyl ether with CAS number 122-99-6.
The antibacterial and anti-inflammatory shower gel comprises the following specific preparation steps:
s1, weighing and mixing the phase A raw materials according to the formula ratio, heating to 80 ℃, and uniformly stirring to obtain a mixture I;
s2, cooling the mixture I to 45 ℃, adding alkali, uniformly stirring, keeping stirring, adding the glycerol derivative, the antioxidant and the water, uniformly stirring, and cooling to obtain a finished product.
Example 3.
The embodiment provides an antibacterial and anti-inflammatory bath lotion which comprises the following raw materials in percentage by weight:
phase A: 45% of deciduous tree extract, 16% of surfactant, 1% of hydantoin derivative, 0.8% of organic acid, 0.1% of synergist and 2% of excipient;
phase B: 0.8% of alkali, 0.8% of glycerol derivative, 0.5% of antioxidant and the balance of water;
the sum of the weight ratios of the phase A and the phase B is 100 percent.
The deciduous arbor extract is a soapberry pericarp extract and is purchased from Guangdong cyanine extraction Biotech limited; the INSI of the Sapindus MUKOROSSI PEEL EXTRACT is Sapindus MUKOROSSI PEEL EXTRACT.
The surfactant is an anionic surfactant, a zwitterionic surfactant and a nonionic surfactant; the weight ratio of the anionic surfactant, the zwitterionic surfactant and the nonionic surfactant is 3: 6: 1.5.
the anionic surfactant is sodium lauroyl sarcosinate (CAS number 137-16-6); the zwitterionic surfactant is cocoamidopropyl betaine (CAS number is 83138-08-3) and disodium cocoyl amphodiacetate (CAS number is 68650-39-5), and the weight ratio of the cocoamidopropyl betaine to the disodium cocoyl amphodiacetate is 1: 1; the nonionic surfactant is cocoyl monoethanolamine (CAS number 68140-00-1).
The hydantoin derivative is 5-ureidohydantoin with a CAS number of 97-59-6.
The organic acid is salicylic acid (CAS number is 69-72-7), the melting point of the salicylic acid is 159 ℃, and the surface tension of the salicylic acid is 64.4 dyne/cm.
The synergist is aminocarboxylic acid and salt thereof, specifically disodium ethylene diamine tetraacetate with CAS number of 139-33-3.
The excipient is an acrylate polymer, and Wuhan Zeshan Daihn Biopharmaceutical technology GmbH.
The alkali is sodium hydroxide; the glycerol derivative is ethylhexyl glycerol with CAS number 70445-33-9, the antioxidant is ethylene glycol phenyl ether with CAS number 122-99-6.
The antibacterial and anti-inflammatory shower gel comprises the following specific preparation steps:
s1, weighing and mixing the phase A raw materials according to the formula ratio, heating to 80 ℃, and uniformly stirring to obtain a mixture I;
s2, cooling the mixture I to 45 ℃, adding alkali, uniformly stirring, keeping stirring, adding the glycerol derivative, the antioxidant and the water, uniformly stirring, and cooling to obtain a finished product.
Example 4.
The embodiment provides an antibacterial and anti-inflammatory bath lotion which comprises the following raw materials in percentage by weight:
phase A: 35% of deciduous tree extract, 13% of surfactant, 0.5% of hydantoin derivative, 0.5% of organic acid, 0.08% of synergist and 1% of excipient;
phase B: 0.3% of alkali, 0.5% of glycerol derivative, 0.3% of antioxidant and the balance of water;
the sum of the weight ratios of the phase A and the phase B is 100 percent.
The deciduous arbor extract is a soapberry pericarp extract and is purchased from Guangdong cyanine extraction Biotech limited; the INSI of the Sapindus MUKOROSSI PEEL EXTRACT is Sapindus MUKOROSSI PEEL EXTRACT.
The surfactant is an anionic surfactant, a zwitterionic surfactant and a nonionic surfactant; the weight ratio of the anionic surfactant, the zwitterionic surfactant and the nonionic surfactant is 4: 4: 1.5.
the anionic surfactant is sodium lauroyl sarcosinate (CAS number 137-16-6); the zwitterionic surfactant is cocoamidopropyl betaine (CAS number is 83138-08-3) and disodium cocoyl amphodiacetate (CAS number is 68650-39-5), and the weight ratio of the cocoamidopropyl betaine to the disodium cocoyl amphodiacetate is 1: 1; the nonionic surfactant is cocoyl monoethanolamine (CAS number 68140-00-1).
The hydantoin derivative is 5-ureidohydantoin with a CAS number of 97-59-6.
The organic acid is salicylic acid (CAS number is 69-72-7), the melting point of the salicylic acid is 159 ℃, and the surface tension of the salicylic acid is 64.4 dyne/cm.
The synergist is aminocarboxylic acid and salt thereof, specifically disodium ethylene diamine tetraacetate with CAS number of 139-33-3.
The excipient is an acrylate polymer, and Wuhan Zeshan Daihn Biopharmaceutical technology GmbH.
The alkali is sodium hydroxide; the glycerol derivative is ethylhexyl glycerol with CAS number 70445-33-9, the antioxidant is ethylene glycol phenyl ether with CAS number 122-99-6.
The antibacterial and anti-inflammatory shower gel comprises the following specific preparation steps:
s1, weighing and mixing the phase A raw materials according to the formula ratio, heating to 80 ℃, and uniformly stirring to obtain a mixture I;
s2, cooling the mixture I to 45 ℃, adding alkali, uniformly stirring, keeping stirring, adding the glycerol derivative, the antioxidant and the water, uniformly stirring, and cooling to obtain a finished product.
Example 5.
The embodiment provides an antibacterial and anti-inflammatory bath lotion, and the specific implementation mode is the same as that of the embodiment 1. Except that the amount of the extract of the larch is 5%.
Example 6.
The embodiment provides an antibacterial and anti-inflammatory bath lotion, and the specific implementation mode is the same as that of the embodiment 1. The difference is that the extract of deciduous trees is guava leaf extract, purchased from west agrelin biotechnology limited; guava has the Latin chemical name Psidiumguajava Linn.
Example 7.
The embodiment provides an antibacterial and anti-inflammatory bath lotion, and the specific implementation mode is the same as that of the embodiment 1. The difference is that the zwitterionic surfactant is a betaine derivative, specifically cocamidopropyl betaine.
Example 8.
The embodiment provides an antibacterial and anti-inflammatory bath lotion, and the specific implementation mode is the same as that of the embodiment 1. The difference is that sodium lauroyl sarcosine is replaced by sodium palmitoyl sarcosine, CAS number 4028-10-8.
Example 9.
The embodiment provides an antibacterial and anti-inflammatory bath lotion, and the specific implementation mode is the same as that of the embodiment 1. The difference is that salicylic acid is replaced by malic acid (CAS number 6915-15-7), the melting point of the malic acid is 131 ℃, and the surface tension is 86.2 dyne/cm.
Example 10.
The embodiment provides an antibacterial and anti-inflammatory bath lotion, and the specific implementation mode is the same as that of the embodiment 1. The difference is that the excipient is carrageenan.
Performance test method
Antibacterial ability:
storing the shower gel prepared in the embodiments 1-10 at room temperature for 3 months, and then testing the antibacterial ability of the shower gel according to GB19877.2-2005, wherein the test strain is staphylococcus aureus; the antibacterial rate of the shower gel is defined to be more than or equal to 90 percent, the antibacterial capacity is strong, the antibacterial rate of the shower gel is 80 to 90 percent, the antibacterial capacity is good, and the antibacterial rate of the shower gel is less than or equal to 80 percent, the antibacterial capacity is poor.
Stability:
the shower gels prepared in examples 1 to 10 were taken, and 10 parallel samples were set for each sample. The samples are sequentially placed at 50 ℃, 40 ℃, 26 ℃ and-4 ℃ for one week respectively, and then are taken out to observe whether the shower gel has the phenomena of layering, turbidity, discoloration and peculiar smell. And recording the number of parallel samples with the phenomena of layering, turbidity, color change and peculiar smell. Foaming force:
the shower gels prepared in examples 1 to 10 were tested for foam height using a Roche foam tester, see GB/T7462-.
Performance test data
TABLE 1 Performance test results
Figure BDA0003120445030000121
Figure BDA0003120445030000131
Finally, it is pointed out that the foregoing examples are illustrative only, serving to explain some of the characteristics of the process according to the invention. The appended claims are intended to claim as broad a scope as is contemplated, and the examples presented herein are merely illustrative of selected implementations in accordance with all possible combinations of examples. Accordingly, it is applicants' intention that the appended claims are not to be limited by the choice of examples illustrating features of the invention. Also, where numerical ranges are used in the claims, subranges therein are included, and variations in these ranges are also to be construed as possible being covered by the appended claims.

Claims (10)

1. The antibacterial and anti-inflammatory shower gel is characterized by comprising the following raw materials in percentage by weight:
phase A: 20-50% of larch extract, 2-20% of surfactant, 0.1-2% of hydantoin derivative, 0.01-2% of organic acid, 0.01-0.1% of synergist and 0.1-5% of excipient;
phase B: 0.01-1% of alkali, 0.02-2% of glycerol derivative, 0.1-1% of antioxidant and the balance of water;
the sum of the weight ratios of the phase A and the phase B is 100 percent.
2. The antibacterial and anti-inflammatory body wash of claim 1, wherein the deciduous tree comprises at least one of soapberry, magnolia, ligustrum lucidum ait, elm, linden, birch, liriodendron, chongyang wood, albizia chinensis, and guava.
3. The antibacterial and anti-inflammatory body wash of claim 1, wherein the surfactant is at least 2 selected from the group consisting of cationic surfactants, anionic surfactants, zwitterionic surfactants, and nonionic surfactants.
4. The antibacterial and anti-inflammatory body wash of claim 3, wherein the surfactant is an anionic surfactant, a zwitterionic surfactant and a nonionic surfactant.
5. The antibacterial and anti-inflammatory bath cream as claimed in claim 4, wherein the weight ratio of the anionic surfactant to the zwitterionic surfactant to the nonionic surfactant is (1-5): (3-8): (0.1-3).
6. The antibacterial and anti-inflammatory body wash of claim 1, wherein the hydantoin derivative comprises at least one of 5-p-hydroxyphenylhydantoin, 5-methyl-5-ethylhydantoin, 5, 5-dimethylhydantoin, and 5-ureidohydantoin.
7. The antibacterial and anti-inflammatory body wash of claim 1, wherein the synergist comprises at least one of polyphosphate, aminocarboxylic acid and its salt, 1, 3-dione, hydroxycarboxylic acid, and polyamine.
8. The antibacterial and anti-inflammatory body wash as claimed in claim 1, wherein the melting point of the organic acid is 150-163 ℃ and the surface tension is 60-70 dyne/cm.
9. The preparation method of the antibacterial and anti-inflammatory shower gel as claimed in any one of claims 1 to 8, which is characterized by comprising the following specific preparation steps:
s1, weighing and mixing the phase A raw materials according to the formula ratio, heating to 70-85 ℃, and uniformly stirring to obtain a mixture I;
s2, cooling the mixture I to 35-48 ℃, adding the phase B raw material, uniformly stirring, and cooling to obtain a finished product.
10. The preparation method of the antibacterial and anti-inflammatory bath cream according to claim 9, wherein in the step S2, the operation of adding the phase B raw materials specifically comprises the following steps: adding alkali, stirring, keeping stirring, and adding glycerol derivative, antioxidant and water.
CN202110674314.XA 2021-06-17 2021-06-17 Antibacterial and anti-inflammatory shower gel and preparation method thereof Pending CN113509414A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113768829A (en) * 2021-10-29 2021-12-10 扬州市永春旅游用品厂 High-foaming shower gel and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103961275A (en) * 2013-02-03 2014-08-06 广州无患子生物科技有限公司 Daily necessities containing all-natural source surfactant and preparation method thereof
CN105816379A (en) * 2016-04-19 2016-08-03 陶红 Relaxing shower gel
CN108078809A (en) * 2018-01-09 2018-05-29 广州市加茜亚化妆品有限公司 A kind of hyperconcetration shower cream and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103961275A (en) * 2013-02-03 2014-08-06 广州无患子生物科技有限公司 Daily necessities containing all-natural source surfactant and preparation method thereof
CN105816379A (en) * 2016-04-19 2016-08-03 陶红 Relaxing shower gel
CN108078809A (en) * 2018-01-09 2018-05-29 广州市加茜亚化妆品有限公司 A kind of hyperconcetration shower cream and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
国产普通化妆品备案信息: "无患子嫩滑柔肤沐浴露", 《HTTPS://HZPBA.NMPA.GOV.CN/GCCX/CHAKAN.HTML?PRODID=926506197522055168&GB=G》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113768829A (en) * 2021-10-29 2021-12-10 扬州市永春旅游用品厂 High-foaming shower gel and preparation method thereof

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