CN113952397B - Fermented traditional Chinese medicine preparation for treating mixed infection of livestock and poultry and preparation method thereof - Google Patents

Abstract

The invention relates to the technical field of traditional Chinese medicines for livestock and poultry, in particular to a fermented traditional Chinese medicine preparation for preventing and treating mixed infection of livestock and poultry and a preparation method thereof. The fermented traditional Chinese medicine preparation comprises the following components in percentage by weight: 55-65% of a traditional Chinese medicine mixture and 35-45% of a yeast culture, wherein the traditional Chinese medicine mixture comprises cacumen biotae, callicarpa nudiflora, ligusticum wallichii, folium artemisiae argyi and cortex phellodendri. The invention has the advantages of good curative effect, quick effect, convenient use, simple production process and no toxic or side effect.

Description

Fermented traditional Chinese medicine preparation for treating mixed infection of livestock and poultry and preparation method thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines for livestock and poultry, in particular to a fermented traditional Chinese medicine preparation for preventing and treating mixed infection of livestock and poultry and a preparation method thereof.

Background

In recent years, the scale of livestock breeding has been expanding, and the degree of intensification and industrialization has been increasing, but there are some problems. For example, (1) the density is too high, (2) the poultry and the livestock are mixedly cultured, and (3) the sanitary condition is poor, so that various mixed infection diseases of bacteria and viruses are mutually transmitted and quickly infected among the poultry and the livestock. When mixed infection diseases occur in the process of breeding livestock and poultry, people generally simply use a large amount of western medicines such as antiviral or antibiotics, antibiotics and the like: florfenicol, polymyxin, gentamicin or pefloxacin, etc. Although the drugs have certain curative effect, the excessive application and the repeated use of a plurality of drugs can cause the burden of liver, gallbladder and kidney of animals to be increased, the drug resistance of bacteria and viruses is generated, and undesirable pathological changes are possibly brought, so that abnormal phenomena such as food preference, food preference or no fat growth occur in the breeding process. If the prevention and treatment are not carried out as early as possible, the death of livestock and poultry and aquaculture animals can be caused in severe cases.

The mixed infection of livestock and poultry is a symptom group with the characteristic of mixed infection of viruses, bacteria and parasites, is caused by mixed infection of more than two viruses or viruses and bacteria, is often accompanied by high fever and respiratory symptoms, is common all the year round, and influences the development of animal husbandry.

The mixed infection of livestock and poultry is caused by various pathogenic factors, but the ultimate cause of death is caused by organism allergy, anoxia, heart failure or endotoxin; various pulmonary abscess and intestinal abscess of livestock and poultry are caused; various hemorrhages such as hemoptysis, epistaxis, hematochezia, and gastrointestinal hemorrhage; various arthritis and rheumatoid arthritis; pulmonary abscess in poultry caused by mycoplasma pneumoniae and mycoplasmas; joint pain, foot turning and ataxia caused by Haemophilus, erysipelas, septicemia streptococcus, pasteurella multocida, salmonella, escherichia coli, etc.

At present, most of the medicines for preventing and treating mixed infection of livestock and poultry are Chinese herbal medicine powder or powder and western medicine preparations, mainly used for treating diseases, although the medicines have certain effect, the caused side effect is very large, especially, the medicines are easy to cause secondary or tertiary infection such as allergy, poisoning and the like of the livestock and poultry, and the prevention effect is very little.

Chinese patent application CN201010273395.4 discloses a pharmaceutical composition for treating mixed infection of livestock and poultry and a preparation method thereof, belonging to the technical field of veterinary preparations. The pharmaceutical composition contains sulfamethoxydiazine sodium, enrofloxacin and a non-steroidal antipyretic analgesic. The pharmaceutical composition of the invention is a liquid preparation for injection. The pharmaceutical composition can effectively relieve clinical symptoms such as fever and the like while treating mixed infection of livestock and poultry, and achieves the effect of treating both principal and secondary aspect of disease. Compared with single-prescription medicines, the compound medicine composition provided by the invention has the advantages that the clinical curative effect is remarkably improved, the stress response of sick livestock is reduced, and the body rehabilitation is facilitated, so that a medicine for efficiently treating mixed infection of livestock and poultry is provided for veterinary clinic. However, the western medicine composition is easy to generate certain drug resistance, has certain toxic and side effects, and the treatment effect needs to be further improved.

Chinese patent application CN201910624992.8 discloses a Chinese medicinal oral liquid for livestock and poultry mixed infection and high fever, which comprises flos Lonicerae, herba Hedyotidis Diffusae, tween, benzyl alcohol, ethanol, ethylparaben, sucrose as main ingredient, and optionally one or more of herba Taraxaci, radix astragali, fructus forsythiae, and lalang grass rhizome. The invention provides a traditional Chinese medicine oral liquid for livestock and poultry mixed infection and high fever, which replaces chemical drugs of antivirus and partial antibiotics and reduces abuse and misuse of the chemical drugs of the antivirus and the antibiotics in domestic markets. However, the oral liquid is mainly used for treating cold and high fever symptoms, has poor prevention effect on various mixed infection symptoms, more auxiliary materials, more complex preparation process and slower drug effect.

Chinese patent application CN200710028068.0 discloses a method for preparing bacterial virus toxin for preventing and treating bacterial virus mixed infection diseases of livestock, poultry and aquatic animals, which comprises the following steps: mixing radix bupleuri, radix Et rhizoma Rhei, rhizoma Coptidis, radix Scutellariae, radix Angelicae sinensis, folium Isatidis, and herba Houttuyniae; leaching with 80-90% ethanol solution, and adding one or more antiviral or antibiotic agents. The bacterial disease toxin can improve the immunity and disease resistance of livestock, poultry and aquatic animals before and after the livestock, the poultry and the aquatic animals are infected with bacterial viruses by the principle of combining traditional Chinese medicine conditioning and western medicine treatment, and has good curative effects, convenient drinking and administration and high absorption rate. However, the preparation method needs various traditional Chinese medicine raw materials, the raw materials are complex, and the traditional Chinese medicine preparation is also combined with western medicines, so that the traditional Chinese medicine preparation is easy to generate drug resistance, the curative effect is unstable, and certain side effects are also caused.

Therefore, it is very necessary to develop a fermented traditional Chinese medicine preparation for preventing and treating mixed infection of livestock and poultry and a preparation method thereof, which can solve the technical problems.

Disclosure of Invention

The invention aims to overcome the defects of the prior art and provides a fermented traditional Chinese medicine preparation for preventing and treating mixed infection of livestock and poultry and a preparation method thereof, wherein the fermented traditional Chinese medicine preparation has the advantages of good curative effect, quick response, convenient use, simple production process and no toxic or side effect.

The invention is realized by the following technical scheme:

a fermented traditional Chinese medicine composition comprises the following components in percentage by weight: 55-65% of a traditional Chinese medicine mixture and 35-45% of a yeast culture, wherein the traditional Chinese medicine mixture comprises cacumen biotae, callicarpa nudiflora, ligusticum wallichii, folium artemisiae argyi and cortex phellodendri.

Callicarpa nudiflora: bitter and cold entering lung and stomach channels, dispelling blood stasis and relieving swelling, astringing and stopping bleeding;

cacumen biotae: bitter, astringent and slightly cold enters the large intestine channels of the lung, liver and intestine, and has the effects of clearing heat, cooling blood, relieving swelling and pain;

ligusticum wallichii: pungent and warm herbs enter pericardium meridian of liver and gallbladder to dispel wind and alleviate pain;

folium artemisiae argyi: bitter and pungent herbs enter liver, spleen and kidney meridians, and are cold in nature at low temperature to stop bleeding and alleviate pain;

phellodendron bark: bitter and cold entering kidney, large intestine and bladder meridians, clearing intestine and checking diarrhea, and clearing damp-heat.

Preferably, the traditional Chinese medicine mixture comprises the following components in parts by weight: 9 to 12 parts of cacumen biotae, 9 to 16 parts of callicarpa nudiflora, 12 to 18 parts of ligusticum wallichii, 6 to 12 parts of folium artemisiae argyi and 9 to 16 parts of phellodendron.

Preferably, the yeast culture comprises saccharomycete and a basic nutrient.

More preferably, the yeast culture further comprises at least one of lactobacillus, bacillus subtilis, and bacillus butyricum.

More preferably, the primary nutrients include biological glycolytic enzymes, vitamins, amino acids, and peptones.

More preferably, the biological glycolytic enzyme comprises at least one of cellulase, protease, lipase and phytase.

More preferably, the yeast culture is a yeast culture of idetide de, purchased from ludwi bio environmental protection technology (suria) ltd.

The invention also relates to a fermented traditional Chinese medicine preparation which comprises the fermented traditional Chinese medicine composition.

The invention also relates to a preparation process of the fermented traditional Chinese medicine preparation, which comprises the following steps:

(1) Pulverizing folium Platycladi, folium Callicarpae Formosanae, rhizoma Ligustici Chuanxiong, folium Artemisiae Argyi and cortex Phellodendri into 80-120 mesh coarse powder, respectively, and mixing to obtain Chinese medicinal mixture;

(2) Mixing the Chinese medicinal mixture and yeast culture for 15-20min, and fermenting together for 10-15 days to obtain fermented Chinese medicinal preparation.

The invention also relates to the application of the fermented traditional Chinese medicine composition or the fermented traditional Chinese medicine preparation prepared by the preparation process in preparing the medicine for preventing and treating mixed infection of livestock and poultry.

Preferably, the expression of the mixed infection of the livestock and the poultry comprises the following steps: pulmonary abscess and intestinal abscess; hemoptysis, epistaxis, hematochezia, and gastrointestinal hemorrhage; arthritis and rheumatoid arthritis; joint pain, walking or ataxia caused by haemophilus, erysipelas, septicemia streptococci, pasteurella multocida, salmonella or escherichia coli.

The invention has the beneficial effects that:

the fermented traditional Chinese medicine composition disclosed by the invention is reasonable in formula. The fermented traditional Chinese medicine composition is prepared by taking one or more probiotics in traditional Chinese medicines and intestinal probiotic flora as strains, simulating the intestinal environment of an animal body and the digestive decomposition process of traditional Chinese medicine components in the animal body in vitro by using a microecology and bionics method and a biological grafting mode, biologically converting the effective components of the traditional Chinese medicines, converting macromolecular substances of the traditional Chinese medicines into small molecular components which can be directly absorbed by the intestinal tract of the animal body through microorganisms, and enabling the traditional Chinese medicines to become novel medicines with quick absorption and quantitative curative effects.

The compatibility principle of the formula of the invention is 'free blood and qi circulation promoting, arthralgia relieving and pain relieving', the monarch drug in the formula is ligusticum wallichii, which is pungent and warm in taste and can free blood and qi circulation promoting, arthralgia relieving and pain relieving; the ministerial drug is golden cypress, which is bitter in taste and cold in nature and can clear intestines, stop diarrhea and remove damp-heat; callicarpa nudiflora, which is bitter and cold in taste, can dissipate blood stasis, relieve swelling, astringe and stop bleeding; the adjuvant drug is cacumen biotae, which is bitter and cold in taste and can clear heat and cool blood, and relieve swelling and pain; the guiding drug is folium artemisiae argyi, which is bitter, pungent and cold in flavor and can warm up and stop bleeding, and pain and bleeding are relieved; the compatibility of the medicines achieves the aims of promoting blood circulation and qi circulation, and relieving arthralgia and pain.

The traditional Chinese medicine has wide sources, is green and environment-friendly, has low cost, and the prepared fermented traditional Chinese medicine composition has quick curative effect, high cure rate, no medicine residue and no toxic or side effect.

The fermented traditional Chinese medicine preparation is superior to western medicines and Chinese herbal medicine powder or pulvis, is convenient to use, has a simple preparation process, and is beneficial to industrial production.

Detailed Description

The invention will be further described with reference to specific embodiments, and the advantages and features of the invention will become apparent as the description proceeds. These examples are illustrative only and do not limit the scope of the present invention in any way. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention, and that such changes and modifications may be made without departing from the spirit and scope of the invention.

The yeast cultures in the following examples are yeast cultures derived from Reid bioscience environmental protection technology (Iris lactea) Inc.

Example 1

The formula proportion is as follows: 20g of cacumen biotae, 30g of beautyberry, 40g of ligusticum wallichii, 20g of folium artemisiae argyi and 30g of phellodendron.

Inspecting the above components in a conventional manner, pulverizing into 100 mesh, and mixing for 15 min to obtain a Chinese medicinal mixture. Adding 65g of the Chinese medicinal mixture into 35g of yeast culture, uniformly mixing for 15 minutes, fermenting for 10 days together, finally preparing into a fermented Chinese medicinal preparation, and subpackaging for later use after the inspection is qualified.

Example 2

The formula proportion is as follows: 25g of cacumen biotae, 35g of beautyberry, 45g of ligusticum wallichii, 25g of folium artemisiae argyi and 35g of phellodendron.

Inspecting the above components in a conventional manner, pulverizing into 120 mesh, and mixing for 20min to obtain a Chinese medicinal mixture. Adding yeast culture 38g into the mixture 62g, mixing uniformly for 20 minutes, fermenting for 10 days, and finally preparing into fermented Chinese medicinal preparation, and subpackaging for use after passing inspection.

Example 3

The formula proportion is as follows: 30g of cacumen biotae, 40g of beautyberry, 50g of ligusticum wallichii, 30g of folium artemisiae argyi and 40g of phellodendron.

Inspecting the above components in a conventional manner, pulverizing into 80 mesh, and mixing for 15 min to obtain a Chinese medicinal mixture. Adding 38g yeast culture into 62g Chinese medicinal mixture, mixing, fermenting for 12 days, and making into fermented Chinese medicinal preparation.

Example 4

The formula proportion is as follows: 35g of cacumen biotae, 45g of beautyberry, 55g of ligusticum wallichii, 35g of folium artemisiae argyi and 45g of phellodendron.

Inspecting the above components in a conventional manner, pulverizing into 100 mesh, and mixing for 15 min to obtain a Chinese medicinal mixture. Adding yeast culture 38g into the mixture 62g, mixing uniformly for 15 minutes, fermenting for 15 days, and finally preparing into fermented Chinese medicinal preparation, and subpackaging for use after passing inspection.

Example 5

The formula proportion is as follows: 40g of cacumen biotae, 50g of beautyberry, 60g of ligusticum wallichii, 40g of folium artemisiae argyi and 50g of phellodendron.

Inspecting the above components in a conventional manner, pulverizing into 100 mesh, and mixing for 15 min to obtain a Chinese medicinal mixture. Adding yeast culture 40g into the Chinese medicinal mixture 60g, mixing uniformly for 15 min, fermenting for 10 days, and preparing into fermented Chinese medicinal preparation, and packaging.

Example 6

The formula proportion is as follows: 45g of cacumen biotae, 55g of callicarpa nudiflora, 65g of ligusticum wallichii, 45g of folium artemisiae argyi and 55g of cortex phellodendri.

Inspecting the above components in a conventional manner, pulverizing into 100 mesh, and mixing for 15 min to obtain a Chinese medicinal mixture. Adding yeast culture 40g into the Chinese medicinal mixture 60g, mixing uniformly for 15 min, fermenting for 10 days, and preparing into fermented Chinese medicinal preparation, and packaging.

Example 7

The formula proportion is as follows: 50g of cacumen biotae, 60g of beautyberry, 70g of ligusticum wallichii, 45g of folium artemisiae argyi and 60g of phellodendron.

Inspecting the above components in a conventional manner, pulverizing into 100 mesh, and mixing for 15 min to obtain a Chinese medicinal mixture. Adding yeast culture 40g into the Chinese medicinal mixture 60g, mixing uniformly for 15 min, fermenting for 15 days, and preparing into fermented Chinese medicinal preparation, and packaging.

Example 8

The formula proportion is as follows: 55g of cacumen biotae, 65g of beautyberry, 75g of ligusticum wallichii, 50g of folium artemisiae argyi and 65g of phellodendron.

Inspecting the above components in a conventional manner, pulverizing into 100 mesh, and mixing for 15 min to obtain a Chinese medicinal mixture. Adding yeast culture 40g into the Chinese medicinal mixture 60g, mixing uniformly for 15 min, fermenting for 10 days, and preparing into fermented Chinese medicinal preparation, and packaging.

Example 9

The formula proportion is as follows: 60g of cacumen biotae, 70g of beautyberry, 80g of ligusticum wallichii, 55g of folium artemisiae argyi and 70g of phellodendron.

Inspecting the above components in a conventional manner, pulverizing into 100 mesh, and mixing for 15 min to obtain a Chinese medicinal mixture. Adding 55g of the Chinese medicinal mixture into 45g of the yeast culture, uniformly mixing for 15 minutes, fermenting for 10 days together, finally preparing into a fermented Chinese medicinal preparation, and subpackaging for later use after the inspection is qualified.

Example 10

The formula proportion is as follows: 65g of cacumen biotae, 75g of beautyberry, 85g of ligusticum wallichii, 60g of folium artemisiae argyi and 75g of phellodendron.

Inspecting the above components in a conventional manner, pulverizing into 100 mesh, and mixing for 15 min to obtain a Chinese medicinal mixture. Adding 55g of the Chinese medicinal mixture into 45g of the yeast culture, uniformly mixing for 15 minutes, fermenting for 10 days together, finally preparing into a fermented Chinese medicinal preparation, and subpackaging for later use after the inspection is qualified.

Comparative example 1

The difference from the example 1 is only that the dosage and the proportion of each component are different, and the rest conditions are the same, and the concrete conditions are as follows:

the formula proportion is as follows: 23g of cacumen biotae, 47g of beautyberry, 12g of ligusticum wallichii, 46g of folium artemisiae argyi and 12g of phellodendron.

Comparative example 2

The differences from the example 1 are that the total mass of the callicarpa nudiflora, the ligusticum wallichii and the golden cypress is unchanged, the callicarpa nudiflora is not contained, and the mass ratio of the ligusticum wallichii to the golden cypress is unchanged, and the specific steps are as follows:

the formula proportion is as follows: 20g of cacumen biotae, 57g of ligusticum wallichii, 20g of folium artemisiae argyi and 43g of phellodendron amurense.

Comparative example 3

The difference from the example 1 is that the total mass of the beautyberry, the Szechuan lovage rhizome and the amur corktree bark is unchanged, the Szechuan lovage rhizome and the amur corktree bark are not contained, and only the beautyberry is contained, and the specific ratio is as follows:

the formula proportion is as follows: 20g of cacumen biotae, 100g of callicarpa nudiflora and 20g of folium artemisiae argyi.

Examples of the effects of the invention

The usage and dosage of the fermented traditional Chinese medicine preparation are as follows: the fermented traditional Chinese medicine preparation is added according to the amount of 0.5 to 1 percent of the full price material and is used for 5 to 10 days.

The dosages of the drugs in the same application cases are the same.

Application case 1

Address: luo a in improved farm of livestock raising in Wanan county of Jiangxi province

In 2018, 2, 27, a writer receives a telephone from a farada in a stock raising farm in Wanan county, and finds out that: has developed for 12 days. Animal complaints: 1200 piglets of 42 days old are purchased from a certain market in Zhejiang province in 2018, 1 month and 2 months, the temperature of a few piglets in 15 months is increased to more than 41 ℃, the piglets have lacrimation, watery nasal discharge, cough, purple peripheral skin and lassitude, the piglets are treated by using the medicines such as benicol, doxycycline, lincomycin, amoxicillin and the like continuously, the treatment is ineffective, more than 180 piglets die continuously, and the initial diagnosis of various pathogenic infections is carried out by pencilers.

The whole pig was divided into two groups, one group consisting of 600 pigs, as a test group, and randomly divided into 4 groups, each of 150 pigs. The products of the invention in the embodiment 1 and the comparative examples 1-3 are respectively added according to 1 percent of the feed in the whole process, and are used for 10 days continuously; by day 6 after administration, the group of example 1 had substantially recovered appetite, improved spirit, relaxed breathing, normal body temperature, decreased mortality, 5 deaths, a survival rate of 96.67%, and recovery of all pigs by day 8. The comparative example 1 group died 25 pigs, the survival rate was 83.33%, and the whole herd of pigs did not recover on day 10; in the comparative example 2, 38 pigs died, the survival rate was 74.67%, and the pigs in the whole group did not recover on day 10; the comparative example 3 group died 47, and the survival rate was 68.67%, and the whole herd of pigs did not recover on day 10.

The two groups are 420 groups in total, and are used as a control group, 20% of florfenicol 1 kg/ton material and 10% of doxycycline 1 kg/ton material are added into the feed, the feed is continuously used for 7 days, and the feed is dead 218 days after the application, which shows that the mixed infection caused by various pathogens has no great effect on the treatment of the antibiotics.

Application case 2

Address: west pit breeding pig farm of Tai and Dabei agricultural fodder Co Ltd

2680 fattening pigs aged 40-60 days are bred in 2019, 4 and 8 days, and due to sultry and humidity in weather, the fattening pigs with poor resistance are easy to infect conditional diseases, so that limb joints of piglets are red, swollen, hot and painful, feet turn, mopping, unstable walking, inappetence, lying on the ground and paralysis on the ground. By 6 days 5 months, the morbidity is 482, the morbidity is nearly 18%, the mortality is 201, and the mortality is nearly 7.5%. During this period, florfenicol, tilmicosin, doxycycline, sulfamonomethoxine sodium, enrofloxacin, lincomycin and Chinese medicine plague-clearing and toxin-vanquishing powder are used, and the improvement of the swinery is still not great. And taking diseased pig joint fluid as a disease material in 5 months and 10 days, sending the disease material to an animal epidemic disease inspection and quarantine analysis laboratory of animal medical colleges of Jiangxi agricultural university for detection, and checking the result in 5 months and 14 days to obtain the mixed infection of the parasitoids, the lung plagues, the streptococcus and the like. The fattening pigs are treated by medication in 16 days in 5 months, and are mixed and fed by fermented traditional Chinese medicine preparations and western medicines, namely, the product of the invention 2, 2 kilograms of 10 percent of florfenicol powder and 2 kilograms of 25 percent of sulfamonomethoxine sodium are added into each ton of the feed according to 1 percent of the feed, and the feed is continuously fed for 5 days. In the period of 5 days of medication, in the rest 2479 pigs, only 57 diseased pigs account for 2.3 percent, only 14 dead pigs account for 0.56 percent, the appetite of the diseased pigs is recovered to be normal, the feces are recovered to be shaped, the urine is recovered, the pigs are clear and bright, the joints of the limbs are not red, heat, pain or lameness, the ataxia is avoided, and only a small amount of transparent liquid is in the joint cavity; during the observation period of 10 days, the symptoms are further improved, all pigs recover, the morbidity and the mortality are zero, and the phenomenon of relapse is avoided. The results show that the western medicines, namely 10% florfenicol and 25% sulfamonomethoxine sodium are surface symptoms for treating diseases, and can improve the red swelling and hot pain of appetite, feces, urine and joints; the fermented traditional Chinese medicine preparation is essential for treating diseases, namely the mixed infection of the parasitized pigs, the pneumonic plague, the streptococcus and the like, has wide sources, low cost, high cure rate, no medicine residue, no toxic or side effect, green, safe, environment-friendly and no residue, has very satisfactory effect and does not relapse.

Application case 3

Address: beef cattle production base place of Taihe county of Jiangxi province

154 beef cattle are raised in 7 and 8 days in 2019, and due to sultry and dampness, the four limbs of some cattle are red, swollen, hot and painful, foot turns, mopping, unstable walking, inappetence, lying on the ground and paralysis of falling on the ground are caused. By 6 days in 9 months, the disease is counted for 6 times, the disease incidence rate is nearly 3.6 percent, florfenicol, tilmicosin, doxycycline, sulfamonomethoxine sodium, enrofloxacin, lincomycin, traditional Chinese medicine antipyretic and antitoxic powder and the like are used in the period, and the cattle herd still has not been greatly improved. Taking diseased cattle joint fluid as a disease material at 10 months and 8 days, sending the disease material to animal epidemic disease inspection and quarantine analysis laboratories of animal medical colleges of Jiangxi agricultural university for detection, and obtaining the inspection conclusion at 10 months and 14 days that the disease is the mixed infection of cattle necrobacillosis, cattle streptococcus and the like. The beef cattle group is recommended to be treated by using a fermented traditional Chinese medicine preparation in 10 months and 16 days, namely, the product is added according to 1 percent of the feed, and the feed is continuously fed for 10 days. In the medication period of 10 days, only 2 sick cattle account for 1.3 percent, the appetite of the sick cattle is recovered to be normal, the excrement is recovered to be shaped, the urine is recovered, the sick cattle are clear and bright, the joints of the limbs are not red, heat or pain, the limbs do not have lameness, the ataxia is avoided, and only a small amount of transparent liquid is in the joint cavity; during the observation period of 20 days later, the product of the invention in the embodiment 3 is continuously added according to the feed amount of 0.5 percent, the symptoms are further improved, the cattle are all recovered, the morbidity and the mortality are zero, and the relapse phenomenon is not seen. The result shows that the fermented traditional Chinese medicine preparation of the invention has very satisfactory effect and no relapse on the mixed infection of the bovine necrobacillosis, the bovine streptococcosis and the like.

Application case 4

Address: deng in Jiangxi Jingan county sheldrake production base

8600 feathers of sheldrake 22 days are bought outside 20 days in 8 months in 2018, due to long-distance transportation stress and sultry in the weather, red, swollen and hot pain of joints of two limbs, lameness and ataxia appear in sheldrake, joint fluid is yellow, viscous and non-transparent liquid, cough, asthma and dyspnea occur, the morbidity is about 12%, namely the morbidity is 1032 feathers, 395 feathers die, and the mortality is about 4.6%. And taking diseased poultry joint fluid as a disease material for 8 months and 30 days, sending the disease material to an animal epidemic disease inspection and quarantine analysis laboratory of animal medical colleges of Jiangxi agricultural university for detection, and checking the conclusion in 9 months and 4 days that the duck is infected with serositis, duck mycoplasma and the like. The batch of sheldrake is treated by medication in 5 days at 9 months, and the fermented traditional Chinese medicine preparation and western medicines of the product of the invention example 5 are mixed for feeding, namely the product of the invention and 10 percent of florfenicol powder are added according to 1 percent of feed for 2 kg/ton of feed, and the mixture is continuously fed for 5 days. In the medication period of 5 days, in the remained sheldrake with 8205 feather, the sick duck has only 48 feather, accounting for 5.8 percent, only 15 feather and accounting for 0.18 percent of death, the appetite of the sick duck is recovered to be normal, the excrement is recovered to be shaped, the joints of the two limbs are not red, heat and pain, the lameness phenomenon and the ataxia phenomenon are avoided, and only a small amount of transparent liquid is in the joint cavity; the product of the invention is added into 0.5 percent of feed for continuous use for 10 days, the symptoms are further improved during the observation period of 10 days, the sheldrake is completely recovered, the morbidity and the mortality are zero, and the relapse phenomenon is avoided. This indicates that the western medicine, i.e. 10% florfenicol, is the surface symptom for treating diseases, improving appetite, feces and joint inflammation and heat pain; the fermented traditional Chinese medicine preparation of the invention is essential for treating diseases, namely mixed infection of duck infectious serositis, duck mycoplasma pneumoniae and the like, has very satisfactory effect and can not relapse.

Application case 5

Address: guo certain production base of Yongfeng county goose raising in Jiangxi province

13680 feathers of 18-day-old goslings are bred in 5-month and 2-day 2020, and are easy to infect conditional diseases due to sultry and dampness, so that the two limbs of the goslings are red, swollen, hot and painful, throw, mopping, unstable walking, inappetence, lying down, and paralysis of the little geese. By 16 days in 5 months, the morbidity rate is 2462, the morbidity rate is approximately 18 percent, the mortality rate is 1000, and the mortality rate is approximately 7.5 percent. In the meantime, florfenicol, tilmicosin, doxycycline, sulfamonomethoxine, enrofloxacin, lincomycin and the Chinese medicine antipyretic and antitoxic powder are used, and the goose herd still has not been greatly improved. And taking diseased goose joint fluid as a disease material for 5-month and 20-day, and sending the disease material to animal epidemic disease inspection and quarantine analysis laboratories of animal medical colleges of Jiangxi agricultural university for detection, wherein the conclusion of 5-month and 24-day inspection is that the goose is infected with mixed infection such as goose gout, goose streptococcus, goose infectious serositis and the like. The gosling is treated by medication in 25 days in 5 months, and the fermented traditional Chinese medicine preparation and western medicines of the product of the embodiment 8 are mixed and fed, namely the product of the invention, 10 percent of florfenicol, 1 kilogram of florfenicol and 25 percent of sulfamonomethoxine sodium, 2 kilograms of sulfamonomethoxine sodium, are added according to 1 percent of feed, and the mixture is continuously fed for 5 days. In the period of 5 days of medication, in the remaining 12650-feather goslings, only 379 feathers of sick fowls account for 3 percent, only 64 feathers of the sick fowls account for 0.5 percent, the appetite of the sick gooses is recovered to be normal, the excrement is recovered to be shaped, the joints of the two limbs are not red, pyrogen or pain, the lameness phenomenon or the ataxia phenomenon is avoided, and only a small amount of transparent liquid is in the joint cavity; the western medicines, namely 10% of florfenicol and 25% of sulfamonomethoxine sodium, are surface symptoms for treating diseases, improve appetite, and the product is continuously added according to 0.5% of feed in the observation period of 10 days later, so that the symptoms are further improved, geese are all recovered, the morbidity is only 0.48%, namely the morbidity is 60, the mortality is zero, and the phenomenon of relapse is not seen. The fermented traditional Chinese medicine preparation is essential for treating diseases, namely mixed infection of goose gout, goose streptococcus, goose infectious serositis and the like, has a very satisfactory effect and does not relapse.

Application case 6

Address: jiangxi province Jian county plum pond Zhenglonga

4800 feather is purchased from laying chicks in 2019, 5, 8 and 21 days, a virulent infectious disease with high morbidity and mortality is found, the virulent infectious disease is clinically characterized by dyspnea, breath opening, loud cough, low-sound wheeze, inappetence, cold intolerance, cold feet and diarrhea, and the pathological anatomy is characterized by diffuse and different sizes of the surfaces and the essence of lung, liver and spleen, and yellow and white dead spots or speckles. The disease materials such as liver, spleen, lymph nodes and the like of the chicken are sent to an animal medical department of Jiangxi agricultural university for epidemic disease detection and analysis research center for detection, and the result system is diagnosed as the mixed infection of the avian reoviridae, the avian infectious bronchitis and the avian infectious laryngotracheitis. During the period, some medicines such as an antiviral medicine isoprinosine, an antipyretic analgesic such as carbapenem calcium, an immunity-increasing medicine such as an astragalus root purified product and a liquorice purified product are used, and antibacterial medicines such as florfenicol, doxycycline, tilmicosin and the like are used for 7 days, but no obvious improvement is obtained, the morbidity reaches 45%, the mortality reaches 34%, and 1600-mourness is died in 30 days after 5 months. The product of the embodiment 10 of the invention is added according to 1 percent of the feed, the feed is uniformly mixed, the chicken flock can feed freely for 5 days continuously, the morbidity is reduced to 23 percent and the mortality is reduced to 11.5 percent by 6 days after the drug is taken, and 368 feathers are killed in total; the addition of the product of the invention at 0.5% of the feed was continued during the observation period of 20 days later. The spirit of the chickens is improved, the body temperature of the chicken flocks is reduced, the appetite is vigorous, the lameness of the chickens is obviously reduced, the morbidity and the mortality are greatly reduced, and the number of new cases is obviously controlled, so that the fermented traditional Chinese medicine preparation has a definite treatment effect on avian infectious bronchitis, avian infectious laryngotracheitis and avian reovirus infection of the chickens.

The above detailed description is specific to one possible embodiment of the present invention, and the embodiment is not intended to limit the scope of the present invention, and all equivalent implementations or modifications without departing from the scope of the present invention should be included in the technical scope of the present invention.

Claims (7)

1. A fermented traditional Chinese medicine composition for treating mixed infection of livestock and poultry is characterized by being prepared from the following components in percentage by weight: 55-65% of a traditional Chinese medicine mixture and 35-45% of a yeast culture, wherein the traditional Chinese medicine mixture is prepared from cacumen biotae, callicarpa nudiflora, ligusticum wallichii, folium artemisiae argyi and cortex phellodendri; the traditional Chinese medicine mixture is prepared from 9-12 parts by weight of cacumen biotae, 9-16 parts by weight of callicarpa nudiflora, 12-18 parts by weight of ligusticum wallichii, 6-12 parts by weight of folium artemisiae argyi and 9-16 parts by weight of cortex phellodendri; the fermented traditional Chinese medicine composition is prepared into a fermented traditional Chinese medicine preparation according to the following steps: (1) Pulverizing folium Platycladi, folium Callicarpae Formosanae, rhizoma Ligustici Chuanxiong, folium Artemisiae Argyi and cortex Phellodendri into 80-120 mesh coarse powder, respectively, and mixing to obtain Chinese medicinal mixture; (2) Mixing the Chinese medicinal mixture and yeast culture for 15-20min, and fermenting together for 10-15 days to obtain fermented Chinese medicinal preparation; the yeast culture includes Saccharomyces, lactobacillus, bacillus subtilis, butyric acid bacillus and basic nutrients.

2. The fermented traditional Chinese medicine composition for treating mixed infection of livestock and poultry according to claim 1, wherein the basic nutrients comprise biological glycolytic enzymes, vitamins, amino acids and peptone.

3. The fermented traditional Chinese medicine composition for treating mixed infections of livestock and poultry according to claim 2, wherein the biological glycolytic enzyme comprises at least one of cellulase, protease, lipase and phytase.

4. A fermented traditional Chinese medicine preparation for treating mixed infection of livestock and poultry, which is characterized by being prepared from the fermented traditional Chinese medicine composition of any one of claims 1 to 3.

5. A preparation process of the fermented traditional Chinese medicine preparation for treating mixed infection of livestock and poultry according to claim 4 is characterized by comprising the following steps:

(1) Pulverizing folium Platycladi, folium Callicarpae Formosanae, rhizoma Ligustici Chuanxiong, folium Artemisiae Argyi and cortex Phellodendri into 80-120 mesh coarse powder, respectively, and mixing to obtain Chinese medicinal mixture;

(2) Mixing the Chinese medicinal mixture and yeast culture for 15-20min, and fermenting together for 10-15 days to obtain fermented Chinese medicinal preparation.

6. The fermented traditional Chinese medicine composition for treating mixed infection of livestock and poultry according to any one of claims 1 to 3, the fermented traditional Chinese medicine preparation for treating mixed infection of livestock and poultry according to claim 4 or the fermented traditional Chinese medicine preparation prepared by the preparation process according to claim 5, and the application thereof in preparing the medicine for treating mixed infection of livestock and poultry.

7. The use of claim 6, wherein the manifestations of mixed infections in livestock and poultry comprise: at least one of joint pain, walking, and ataxia.