CN113925804A - Amino acid facial cleanser - Google Patents
Amino acid facial cleanser Download PDFInfo
- Publication number
- CN113925804A CN113925804A CN202111032185.0A CN202111032185A CN113925804A CN 113925804 A CN113925804 A CN 113925804A CN 202111032185 A CN202111032185 A CN 202111032185A CN 113925804 A CN113925804 A CN 113925804A
- Authority
- CN
- China
- Prior art keywords
- facial cleanser
- peach gum
- cellulose
- cyclodextrin
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000001815 facial effect Effects 0.000 title claims abstract description 56
- 150000001413 amino acids Chemical class 0.000 title claims abstract description 27
- 235000006040 Prunus persica var persica Nutrition 0.000 claims abstract description 35
- 239000000203 mixture Substances 0.000 claims abstract description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000004094 surface-active agent Substances 0.000 claims abstract description 18
- 241000219357 Cactaceae Species 0.000 claims abstract description 16
- 239000003755 preservative agent Substances 0.000 claims abstract description 7
- 230000002335 preservative effect Effects 0.000 claims abstract description 7
- 150000005846 sugar alcohols Polymers 0.000 claims abstract description 5
- 244000144730 Amygdalus persica Species 0.000 claims description 33
- 150000004676 glycans Chemical class 0.000 claims description 25
- 229920001282 polysaccharide Polymers 0.000 claims description 25
- 239000005017 polysaccharide Substances 0.000 claims description 25
- 235000001014 amino acid Nutrition 0.000 claims description 23
- 229920000858 Cyclodextrin Polymers 0.000 claims description 22
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 20
- 238000001471 micro-filtration Methods 0.000 claims description 20
- -1 methyl cyclodextrin Chemical compound 0.000 claims description 19
- 239000002085 irritant Substances 0.000 claims description 17
- 239000012528 membrane Substances 0.000 claims description 16
- 238000002360 preparation method Methods 0.000 claims description 13
- 239000006228 supernatant Substances 0.000 claims description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 239000000706 filtrate Substances 0.000 claims description 8
- 235000011187 glycerol Nutrition 0.000 claims description 7
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 6
- 239000004375 Dextrin Substances 0.000 claims description 6
- 229920001353 Dextrin Polymers 0.000 claims description 6
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 6
- 229920001479 Hydroxyethyl methyl cellulose Polymers 0.000 claims description 6
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 6
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 6
- 235000019425 dextrin Nutrition 0.000 claims description 6
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 6
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 6
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 6
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 6
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 6
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 6
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 6
- 229920000609 methyl cellulose Polymers 0.000 claims description 6
- 239000001923 methylcellulose Substances 0.000 claims description 6
- 235000010981 methylcellulose Nutrition 0.000 claims description 6
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 6
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 6
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 6
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 6
- 229910052708 sodium Inorganic materials 0.000 claims description 6
- 239000011734 sodium Substances 0.000 claims description 6
- 239000002562 thickening agent Substances 0.000 claims description 6
- 125000002091 cationic group Chemical group 0.000 claims description 5
- 239000003995 emulsifying agent Substances 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- RFRMMZAKBNXNHE-UHFFFAOYSA-N 6-[4,6-dihydroxy-5-(2-hydroxyethoxy)-2-(hydroxymethyl)oxan-3-yl]oxy-2-(hydroxymethyl)-5-(2-hydroxypropoxy)oxane-3,4-diol Chemical compound CC(O)COC1C(O)C(O)C(CO)OC1OC1C(O)C(OCCO)C(O)OC1CO RFRMMZAKBNXNHE-UHFFFAOYSA-N 0.000 claims description 4
- 238000013329 compounding Methods 0.000 claims description 4
- 239000011780 sodium chloride Substances 0.000 claims description 4
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 3
- 235000004279 alanine Nutrition 0.000 claims description 3
- 239000000919 ceramic Substances 0.000 claims description 3
- 229940071160 cocoate Drugs 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 3
- 229920005862 polyol Polymers 0.000 claims description 3
- 150000003077 polyols Chemical class 0.000 claims description 3
- 239000011148 porous material Substances 0.000 claims description 3
- 229940079988 potassium cocoyl glycinate Drugs 0.000 claims description 3
- 229940060304 sodium myristoyl sarcosinate Drugs 0.000 claims description 3
- KHCOJQDJOCNUGV-UHFFFAOYSA-M sodium;2-[methyl(tetradecanoyl)amino]acetate Chemical compound [Na+].CCCCCCCCCCCCCC(=O)N(C)CC([O-])=O KHCOJQDJOCNUGV-UHFFFAOYSA-M 0.000 claims description 3
- 229940104261 taurate Drugs 0.000 claims description 3
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims description 3
- 241000903946 Clematidis Species 0.000 claims description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 2
- 229960003767 alanine Drugs 0.000 claims description 2
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 2
- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 claims description 2
- 229940086539 peg-7 glyceryl cocoate Drugs 0.000 claims description 2
- 229940079781 sodium cocoyl glutamate Drugs 0.000 claims description 2
- 230000007794 irritation Effects 0.000 abstract description 12
- 238000004140 cleaning Methods 0.000 abstract description 11
- 238000002474 experimental method Methods 0.000 abstract description 8
- 239000000126 substance Substances 0.000 abstract description 6
- 240000006413 Prunus persica var. persica Species 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 17
- 210000003743 erythrocyte Anatomy 0.000 description 12
- 210000003837 chick embryo Anatomy 0.000 description 11
- 230000000052 comparative effect Effects 0.000 description 10
- 239000000047 product Substances 0.000 description 10
- 238000005406 washing Methods 0.000 description 10
- 235000013601 eggs Nutrition 0.000 description 9
- 206010018910 Haemolysis Diseases 0.000 description 7
- 238000001035 drying Methods 0.000 description 7
- 239000006260 foam Substances 0.000 description 7
- 230000008588 hemolysis Effects 0.000 description 7
- 230000001954 sterilising effect Effects 0.000 description 7
- 238000003756 stirring Methods 0.000 description 7
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 6
- 210000003711 chorioallantoic membrane Anatomy 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 239000002994 raw material Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 238000004659 sterilization and disinfection Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 239000000344 soap Substances 0.000 description 4
- GUTLYIVDDKVIGB-OUBTZVSYSA-N Cobalt-60 Chemical compound [60Co] GUTLYIVDDKVIGB-OUBTZVSYSA-N 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 238000004108 freeze drying Methods 0.000 description 3
- 239000002304 perfume Substances 0.000 description 3
- 238000010298 pulverizing process Methods 0.000 description 3
- 238000007873 sieving Methods 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 2
- 102000002322 Egg Proteins Human genes 0.000 description 2
- 108010000912 Egg Proteins Proteins 0.000 description 2
- FPVVYTCTZKCSOJ-UHFFFAOYSA-N Ethylene glycol distearate Chemical group CCCCCCCCCCCCCCCCCC(=O)OCCOC(=O)CCCCCCCCCCCCCCCCC FPVVYTCTZKCSOJ-UHFFFAOYSA-N 0.000 description 2
- 241000287828 Gallus gallus Species 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- 239000004809 Teflon Substances 0.000 description 2
- 229920006362 Teflon® Polymers 0.000 description 2
- 239000002390 adhesive tape Substances 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 235000019864 coconut oil Nutrition 0.000 description 2
- 239000003240 coconut oil Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 229940097362 cyclodextrins Drugs 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000005187 foaming Methods 0.000 description 2
- 229940049294 glyceryl stearate se Drugs 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 210000004379 membrane Anatomy 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 239000003002 pH adjusting agent Substances 0.000 description 2
- 229940100460 peg-100 stearate Drugs 0.000 description 2
- 229960005323 phenoxyethanol Drugs 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 229940057950 sodium laureth sulfate Drugs 0.000 description 2
- SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- NLMOYOROJZUUMN-UHFFFAOYSA-N 2,3-dihydroxypropyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO.CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO NLMOYOROJZUUMN-UHFFFAOYSA-N 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 description 1
- 229940100555 2-methyl-4-isothiazolin-3-one Drugs 0.000 description 1
- FZIPCQLKPTZZIM-UHFFFAOYSA-N 2-oxidanylpropane-1,2,3-tricarboxylic acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.OC(=O)CC(O)(C(O)=O)CC(O)=O FZIPCQLKPTZZIM-UHFFFAOYSA-N 0.000 description 1
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 description 1
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
- 229940100484 5-chloro-2-methyl-4-isothiazolin-3-one Drugs 0.000 description 1
- 244000140786 Brassica hirta Species 0.000 description 1
- 235000011371 Brassica hirta Nutrition 0.000 description 1
- JDRSMPFHFNXQRB-CMTNHCDUSA-N Decyl beta-D-threo-hexopyranoside Chemical compound CCCCCCCCCCO[C@@H]1O[C@H](CO)C(O)[C@H](O)C1O JDRSMPFHFNXQRB-CMTNHCDUSA-N 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- MKYBYDHXWVHEJW-UHFFFAOYSA-N N-[1-oxo-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propan-2-yl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(C(C)NC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 MKYBYDHXWVHEJW-UHFFFAOYSA-N 0.000 description 1
- 240000005809 Prunus persica Species 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- NWGKJDSIEKMTRX-BFWOXRRGSA-N [(2r)-2-[(3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)C1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-BFWOXRRGSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 210000001643 allantois Anatomy 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- ILMMCBFQWHPTHE-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O.CCCC(O)O ILMMCBFQWHPTHE-UHFFFAOYSA-N 0.000 description 1
- 229960001631 carbomer Drugs 0.000 description 1
- 229920006317 cationic polymer Polymers 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- DHNRXBZYEKSXIM-UHFFFAOYSA-N chloromethylisothiazolinone Chemical compound CN1SC(Cl)=CC1=O DHNRXBZYEKSXIM-UHFFFAOYSA-N 0.000 description 1
- 229960004106 citric acid Drugs 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 description 1
- 229940073507 cocamidopropyl betaine Drugs 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 229940073499 decyl glucoside Drugs 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000005238 degreasing Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 229940079868 disodium laureth sulfosuccinate Drugs 0.000 description 1
- 229940079886 disodium lauryl sulfosuccinate Drugs 0.000 description 1
- YGAXLGGEEQLLKV-UHFFFAOYSA-L disodium;4-dodecoxy-4-oxo-2-sulfonatobutanoate Chemical compound [Na+].[Na+].CCCCCCCCCCCCOC(=O)CC(C([O-])=O)S([O-])(=O)=O YGAXLGGEEQLLKV-UHFFFAOYSA-L 0.000 description 1
- KHIQYZGEUSTKSB-UHFFFAOYSA-L disodium;4-dodecoxy-4-oxo-3-sulfobutanoate Chemical compound [Na+].[Na+].CCCCCCCCCCCCOC(=O)C(S(O)(=O)=O)CC([O-])=O.CCCCCCCCCCCCOC(=O)C(S(O)(=O)=O)CC([O-])=O KHIQYZGEUSTKSB-UHFFFAOYSA-L 0.000 description 1
- OKBPCTLSPGDQBO-UHFFFAOYSA-L disodium;dichloride Chemical compound [Na+].[Na+].[Cl-].[Cl-] OKBPCTLSPGDQBO-UHFFFAOYSA-L 0.000 description 1
- 210000003278 egg shell Anatomy 0.000 description 1
- 229940012466 egg shell membrane Drugs 0.000 description 1
- 235000014103 egg white Nutrition 0.000 description 1
- 210000000969 egg white Anatomy 0.000 description 1
- 238000005485 electric heating Methods 0.000 description 1
- 210000002257 embryonic structure Anatomy 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 229940100524 ethylhexylglycerin Drugs 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 210000001161 mammalian embryo Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- BEGLCMHJXHIJLR-UHFFFAOYSA-N methylisothiazolinone Chemical compound CN1SC=CC1=O BEGLCMHJXHIJLR-UHFFFAOYSA-N 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 229940105132 myristate Drugs 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 238000000643 oven drying Methods 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229940094541 polyglycerin-10 Drugs 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/738—Cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
- A61K8/8176—Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/81—Preparation or application process involves irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Sustainable Development (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Microbiology (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to an amino acid facial cleanser, and belongs to the field of daily chemicals. The facial cleanser comprises an amino acid surfactant, polyhydric alcohol, an anti-irritation composition, a preservative and water, wherein the anti-irritation composition comprises peach gum extract and cactus extract. Experiments prove that after the anti-irritation composition is added into the amino acid facial cleanser, irritation can be effectively reduced, and dry and astringent feeling after face cleaning can be relieved.
Description
Technical Field
The invention relates to an amino acid facial cleanser, and belongs to the field of daily chemicals.
Background
The main types of common facial cleansers in the market are soap-based facial cleansers and surfactant (surfactant for short) facial cleansers. The soap-based facial cleanser has the characteristics of good cleaning power, fresh and cool skin after washing and the like, but has the problems of strong degreasing capability, strong irritation and the like. The conventional surfactant facial cleanser brings good cleaning power and is often accompanied with certain irritation, and symptoms such as erythema, irritation, dryness or pruritus of the skin can be caused.
In order to solve these problems, amino acid facial cleansers have been introduced on the market, which are not only free from the tight and dry feeling of soap-based products but also have a strong moisturizing feeling after use. The amino acid facial cleanser is a non-soap base type facial cleanser mainly comprising amino acid surfactants (such as sodium cocoyl taurate, sodium cocoyl alanine and sodium myristoyl sarcosinate), is weakly acidic and is close to the pH value of human skin. The amino acid surfactant has high safety to environment and organism, good biocompatibility, good foaming and emulsifying properties and the like. Although the amino acid surfactant in the amino acid facial cleanser is milder than the conventional surfactant, the amino acid surfactant still has certain irritation. Therefore, the development of a less irritating amino acid facial cleanser has been the focus of attention of the skilled person.
Disclosure of Invention
Based on the defects of the prior art, the invention aims to provide the mild amino acid facial cleanser, which can effectively reduce the irritation of a surfactant to the skin and further inhibit inflammatory reaction on the basis of keeping the original cleaning effect.
In order to achieve the purpose, the invention adopts the following technical scheme:
in a first aspect, the present invention provides a mild amino acid facial cleanser comprising: amino acid surfactant, polyalcohol, an anti-irritation composition, preservative and water, wherein the anti-irritation composition comprises peach gum extract.
According to some embodiments of the invention, the peach gum extract comprises more than 30% by mass of peach gum polysaccharides.
According to a preferred embodiment of the present invention, the peach gum extract contains more than 50% by mass of peach gum polysaccharide.
According to a preferred embodiment of the present invention, the peach gum extract contains more than 70% by mass of peach gum polysaccharide.
According to some embodiments of the invention, the peach gum polysaccharide has an average molecular weight of 100-500 wDa.
According to some preferred embodiments of the present invention, the peach gum polysaccharide has an average molecular weight of 200-300 wDa.
According to some more preferred embodiments of the present invention, the average molecular weight of the peach gum polysaccharide is 240-280 wDa.
According to some embodiments of the invention, the anti-irritant composition further comprises a cactus extract.
According to some embodiments of the invention, the anti-irritant composition comprises the peach gum polysaccharide and the cactus polysaccharide having a polysaccharide average molecular weight of 100-500 wDa.
According to some preferred embodiments of the present invention, the anti-irritant composition comprises the peach gum polysaccharide and the cactus polysaccharide having a polysaccharide average molecular weight of 200-300 wDa.
According to some more preferred embodiments of the present invention, the anti-irritant composition comprises the peach gum polysaccharide and the cactus polysaccharide having a polysaccharide average molecular weight of 240-280 wDa.
According to some embodiments of the invention, the anti-irritant composition further comprises as component 3) one or more of dextrin, cyclodextrin, methyl cyclodextrin, hydroxypropyl cyclodextrin, trehalose, polyvinylpyrrolidone, methyl cellulose, methylhydroxyethyl cellulose, hydroxypropylmethyl cellulose, hydroxyethyl cellulose and hydroxypropyl cellulose.
According to some preferred embodiments of the present invention, the anti-irritant composition is prepared by a process comprising the steps of:
(1) extracting peach gum and optional radix Clematidis with water to obtain primary extractive solution;
(2) and centrifuging the primary extract to obtain a supernatant.
According to some embodiments of the invention, the weight ratio of peach gum to cactus in the anti-irritant composition is 1: 5-15: 1.
according to some preferred embodiments of the invention, the weight ratio of peach gum to cactus in the anti-irritant composition is 1: 10-10: 1.
according to some embodiments of the present invention, the extraction temperature in step (1) is 50-90 ℃, for example, 50 ℃, 51 ℃, 52 ℃, 53 ℃, 54 ℃, 55 ℃, 56 ℃, 57 ℃, 58 ℃, 59 ℃, 60 ℃, 61 ℃, 62 ℃, 65 ℃, 68 ℃, 69 ℃, 70 ℃, 75 ℃, 78 ℃, 80 ℃, 82 ℃, 84 ℃, 88 ℃, 90 ℃, and the values between these values.
According to a preferred embodiment of the present invention, in the step (1), the extraction temperature is 60 to 75 ℃, and may be, for example, 60 ℃, 61 ℃, 62 ℃, 65 ℃, 68 ℃, 69 ℃, 70 ℃, 75 ℃.
According to some embodiments of the present invention, the extraction time in step (1) is 0.5-5h, and may be, for example, 30min, 40min, 50min, 1 h, 1.5 h, 2h, 2.5 h, 3h, 3.5h, 4h, 5h, and points between these values.
According to some embodiments of the invention, the weight ratio of the total weight of peach gum and cactus to water in step (1) is 1: 10-1: 50, for example, may be 1: 10 (m/m), 1: 11 (m/m), 1: 12 (m/m), 1: 13 (m/m), 1: 14 (m/m), 1: 15 (m/m), 1: 16 (m/m), 1: 17 (m/m), 1: 18 (m/m), 1: 20 (m/m), 1: 25 (m/m), 1: 27 (m/m), 1: 30 (m/m), 1: 32 (m/m), 1: 35 (m/m), 1: 36 (m/m), 1: 39 (m/m), 1: 40 (m/m), 1: 41 (m/m), 1: 42 (m/m), 1: 45 (m/m), 1: 48 (m/m), 1: 50 (m/m).
According to a preferred embodiment of the present invention, in the step (1), the weight ratio of the total weight of the peach gum and the cactus to the water is 1: 20-1: 40, can be 1: 20 (m/m), 1: 25 (m/m), 1: 27 (m/m), 1: 30 (m/m), 1: 32 (m/m), 1: 35 (m/m), 1: 36 (m/m), 1: 39 (m/m), 1: 40 (m/m).
According to some embodiments of the present invention, the centrifugation in the step (2) is 4000-8000rpm for 5-30 min.
According to some embodiments of the invention, the method of preparing the anti-irritant composition further comprises step (3): and (3) carrying out microfiltration on the supernatant obtained in the step (2) by adopting a microfiltration membrane component to obtain a micro-filtrate.
According to some embodiments of the invention, the step (2) microfiltration membrane module is selected from a ceramic microfiltration membrane module or a roll-type microfiltration membrane module.
According to some embodiments of the invention, the pore size of the microfiltration membrane module is between 50 and 200 nm.
According to some embodiments of the invention, the pore size of the microfiltration membrane module is 100 nm.
According to some embodiments of the invention, the method of preparing the anti-irritant composition further comprises step (4): and (4) compounding the micro-filtrate obtained in the step (3) with one or more of dextrin, cyclodextrin, methyl cyclodextrin, hydroxypropyl cyclodextrin, trehalose, polyvinylpyrrolidone, methyl cellulose, methyl hydroxyethyl cellulose, hydroxypropyl methyl cellulose, hydroxyethyl cellulose or hydroxypropyl cellulose to obtain a compound.
According to some embodiments of the invention, the weight ratio of the micro filtrate to one or more of dextrin, cyclodextrin, methyl cyclodextrin, hydroxypropyl cyclodextrin, trehalose, polyvinylpyrrolidone, methyl cellulose, methyl hydroxyethyl cellulose, hydroxypropyl methyl cellulose, hydroxyethyl cellulose or hydroxypropyl cellulose is 1: 1-1: 20.
according to some embodiments of the present invention, the compound obtained in step (4) may be dried and sterilized before use.
According to some embodiments of the invention, the drying is freeze-drying at-80 ℃ to-50 ℃ for 8 to 32 h.
According to some embodiments of the invention, the drying is spray drying, the inlet air temperature is 100 ℃ and 170 ℃, and the material flow rate is controlled to be 5-50 mL/min.
According to some embodiments of the invention, the drying is oven drying at 90-150 ℃ for 12-50h, pulverizing and sieving with a 80 mesh sieve, and taking the undersize fraction.
According to some embodiments of the invention, the sterilization process is cobalt 60 sterilization for 1-8 h.
According to some embodiments of the present invention, the sterilization is performed by using 100-700W microwave for 0.5-30 min.
According to some embodiments of the invention, the sterilization is dry heat sterilization at 90-150 ℃ for 0.5-5 h.
According to some embodiments of the invention, the amino acid surfactant is one or more of potassium cocoyl glycinate, sodium cocoyl taurate, sodium cocoyl alanine, sodium myristoyl sarcosinate or sodium cocoyl glutamate.
According to some embodiments of the invention, the polyol is one or more of glycerol, propylene glycol or dipropylene glycol.
According to some embodiments of the invention, the facial cleanser further comprises one or more of a cationic conditioner, a thickener, an emulsifier, a pearlizing agent, PEG-7 glyceryl cocoate, a pH adjuster, sodium chloride, and a perfume.
According to some embodiments of the invention, the cationic conditioning agent is a cationic polymer, and may be, for example, one or both of polyquaternium-7 and polyquaternium-10.
According to some embodiments of the present invention, the thickener is a conventional thickener in the art, and may be one or more of acrylic acid (ester) copolymer, polyacrylic acid, carbomer, xanthan gum or cellulose, for example.
According to some embodiments of the invention, the emulsifier is conventional in the art, and may be, for example, one or both of glyceryl stearate SE, PEG-100 stearate.
According to some embodiments of the invention, the pearlescent agent is ethylene glycol distearate.
According to some embodiments of the present invention, the pH adjusting agent is a preparation that is conventional in the art for adjusting pH, and may be, for example, citric acid or sodium citrate, and adjusts the pH of the system to 5-7.
According to some embodiments of the invention, the preservative is a preservative conventional in the art, and may be, for example, phenoxyethanol/ethylhexyl glycerol, methylisothiazolinone/methylchloroisothiazolinone.
According to some embodiments of the invention, the perfume is a perfume conventional in the art.
According to some embodiments of the invention, the amounts of the components of the facial cleanser are as follows: 10.00-40.00wt% of amino acid surfactant, 5.00-30.00wt% of polyalcohol, 0.00-0.50wt% of cationic conditioner, 0.00-8.00wt% of thickening agent, 0.00-3.00 wt% of PEG-7 glycerol cocoate, 0.00-6.00 wt% of emulsifier, 0.00-3.00 wt% of pearling agent, 0.00-2.00 wt% of pH regulator, 0.00-2.00 wt% of sodium chloride, 0.01-5.00 wt% of anti-irritation composition, 0.05-1.00 wt% of preservative and 0.00-1.00 wt% of essence.
According to some preferred embodiments of the present invention, the facial cleanser may further include one or more of sodium laureth sulfate (AES), disodium laureth sulfosuccinate, cocamidopropyl betaine, decyl glucoside, and other surfactants.
According to some embodiments of the invention, the additional surfactant is present in an amount of 0.00 to 10.00 wt%.
The invention has the beneficial effects that:
experiments prove that the irritation resistant composition added into the amino acid facial cleanser can effectively reduce irritation and relieve dry and unsmooth feeling after face cleaning while keeping the foamability, cleaning power, skin feeling and the like of the facial cleanser.
The specific implementation mode is as follows:
in order that the invention may be more readily understood, reference will now be made in detail to the following examples. It will be understood by those skilled in the art that the embodiments of the present invention are illustrative only and not limiting of the invention. The specific experimental methods which are not mentioned in the examples of the invention are all conventional methods in the field. The reagents or apparatus used are conventional products commercially available from normal sources, not indicated by the manufacturer.
TABLE 1 raw materials and suppliers
| Name of raw materials | INCI name | Source of raw materials |
| Coconut oil acyl potassium glycinate | Coconut oil acyl potassium glycinate | Shanghai Lisheng Chemicals Co., Ltd |
| Water (W) | Water (W) | Self-made |
| Butanediol | Butanediol | Beijing century Hongkai science and technology development Co Ltd |
| AES | Sodium laureth sulfate | Shanghai Kao Chemical Co.,Ltd. |
| Sodium chloride | Sodium chloride | SINOPHARM CHEMICAL REAGENT Co.,Ltd. |
| Polyquaternium-7 | Polyquaternium-7 | Shanghai Lisheng Chemicals Co., Ltd |
| HE | PEG-7 Glycerol cocoate | BASF CHINA Co.,Ltd. |
| Glycerol stearate | Glycerol stearate | Beijing Jie Huatai and science and technology Limited liability company |
| Glycerol stearate SE | Glycerol stearate SE | Beijing Boda Libang Technology Co., Ltd. |
| Pearling agent | Ethylene glycol distearate | Shanghai Kao Chemical Co.,Ltd. |
| ARLACEL 170 | Glycerol stearate/PEG-100 stearate | Beijing Boda Libang Technology Co., Ltd. |
| Citric acid | Citric acid | SINOPHARM CHEMICAL REAGENT Co.,Ltd. |
| PEHG | Phenoxyethanol/ethylhexyl glycerin | Turkey Torr |
| Peach gum | —— | Sui county Hengyuan auspicious commercial and trade company Limited |
| Radix et caulis Opuntiae Dillenii | —— | Nippon Shangyu constant exposure edible agricultural products Co Ltd |
| Hydroxypropyl cyclodextrins | Hydroxypropyl cyclodextrins | SHANDONG BINZHOU ZHIYUAN BIOTECHNOLOGY Co.,Ltd. |
TABLE 2 Instrument information List
| Name of instrument | Specification and model | Manufacturer of the product |
| Electronic balance | ML204/02 | Mettlerlatio instruments (Shanghai) Co Ltd |
| Digital display constant temperature water bath | HH-2 | Yanghua Jintan City, Jiangsu province, manufacturing Limited company of instruments |
| IKA RW16 stirrer | RW 16 B S25 | IKA (Ika) instruments and Equipment, Guangzhou, Inc |
| IKA T18 homogenizer | T18 B | IKA (Ika) instruments and Equipment, Guangzhou, Inc |
| Precise timing electric stirrer | JJ-1 | Yanghua Jintan City, Jiangsu province, manufacturing Limited company of instruments |
| High-speed centrifugal machine | eppendorf centrifuge 5430 | eppendorf AG |
| Microfiltration membrane module equipment | CeraMem-0025 | XIAMEN FILTER AND MEMBRANE TECHNOLOGY Co.,Ltd. |
| Freeze dryer | FD-1A-50 | Shanghai Yuming Instrument Co., Ltd |
| Spray drier | QIMO-8000T | Qimo (Shanghai) electronic technology Co., Ltd |
| Multifunctional pulverizer | BJ-800A | DEQING BAIJIE ELECTRIC APPLIANCE Co.,Ltd. |
| Electric heating constant temperature blast air drying box | DHG-9070A | Shanghai Jinghong experiment equipment Co Ltd |
| Electric ceramic stove | LC-E190S | Country electric appliances Co Ltd |
| Stirrer | RW 16 B S25 | Ika instrument equipment Guangzhou limited public |
Example 1 facial cleanser preparation
Example 2 facial cleanser preparation
Example 3 facial cleanser preparation
Example 4 facial cleanser preparation
Example 5 facial cleanser preparation
Example 6 facial cleanser preparation
Example 7 facial cleanser preparation
Example 8 facial cleanser preparation
The anti-irritation composition is prepared by the following steps:
anti-irritant composition a: adding 50 parts of pure water into 1 part of peach gum and 1 part of cactus, extracting with pure water, and extracting for 2 hours at 80 ℃; centrifuging at 5000rpm/min for 20min, and collecting supernatant; performing microfiltration and concentration by using a 100nm microfiltration membrane component, removing substances with the molecular weight below 100wDa in the supernatant, and retaining the effluent liquid to obtain a microfiltration solution; according to the micro-filtrate: hydroxypropyl cyclodextrin = 1: 5 (m/m) compounding; freeze-drying the compounded substance at-80 deg.C for 12 h; pulverizing, sieving with 80 mesh sieve, and collecting the sieved part; sterilizing with cobalt 60 for 3 hr to obtain anti-irritation composition A.
In the anti-irritation composition A, the average molecular weight of the peach gum polysaccharide is 100-500 wDa.
Anti-irritant composition B: adding 50 parts of pure water into 1 part of peach gum and 1 part of cactus, extracting with pure water, and extracting for 2 hours at 80 ℃; centrifuging at 5000rpm/min for 20min, and collecting supernatant; performing microfiltration and concentration by using a 100nm microfiltration membrane component, removing substances with the molecular weight below 100wDa in the supernatant, and retaining the effluent liquid to obtain a microfiltration solution; according to the micro-filtrate: hydroxypropyl cyclodextrin = 1: 10 (m/m) compounding; freeze-drying the compounded substance at-80 deg.C for 12 h; pulverizing, sieving with 80 mesh sieve, and collecting the sieved part; sterilizing with cobalt 60 for 3 hr to obtain anti-irritation composition B.
In the anti-irritation composition B, the average molecular weight of the peach gum polysaccharide is 100-500 wDa.
The preparation process of the facial cleanser comprises the following steps:
(1) dispersing polyalcohol in water, adding phase A other raw materials, stirring, heating to 80-85 deg.C, and keeping the temperature;
(2) respectively weighing phase B and phase C raw materials, stirring, and heating to 80-85 deg.C;
(3) slowly adding phase B and phase C into phase A under stirring, and homogenizing for 3-10 min;
(4) stirring until the system turns white or cools to 50-60 deg.C, adding prepared phase D, adjusting pH to 5.0-7.0, and stirring;
(5) cooling to 45 deg.C, adding phase E, and stirring;
(6) stirring and cooling to room temperature, and discharging.
Other examples and comparative examples facial cleanser preparation:
the compositions and proportions of the facial cleanser of comparative example 1 and examples 9-12 are shown in the following table:
off-line state observation and skin feel stability test
| Example 1 | Example 9 | Example 10 | Example 11 | Example 12 | Comparative example 1 | |
| State observation | The state is acceptable | Has precipitation and granular sensation | The state is thicker | The state is acceptable | The state is acceptable | The state is acceptable |
| Skin feel | Rich foam and no dryness after washing | Is not easy to push open | Is not easy to push away and bubble | Excessive foam and heavy feeling of residue after washing | Poor foamability | Dry and astringent skin after washing |
After the facial cleanser is manufactured, the off-line state observation is carried out, and the use performance of the facial cleanser is tested. And observing whether the offline product has unstable phenomena such as layering, precipitation, over-thin and over-thick phenomena or not, and if not, the state is acceptable. Then, the soybean grain-sized facial cleanser is taken for cleaning test, and the foaming power, the cleaning power and the skin feeling after washing are observed.
The results of the off-line state observation and the skin feel stability test show that:
the cleaning agent of the embodiment 1 of the invention has the advantages of good offline state, abundant foam, good cleaning power and no dryness after washing. Meanwhile, comparative example 1 was good in condition and relatively acceptable in skin feel.
Evaluation of skin irritation and anti-inflammatory Effect
And (3) testing a sample: example 1 facial cleanser, comparative example 1 facial cleanser, commercial facial wash contest (main ingredients: glycerin, potassium cocoyl glycinate, water, butylene glycol, disodium lauryl sulfosuccinate, polyglycerin-10 myristate, glyceryl stearate SE, citric acid, etc.).
(I) irritation reduction test
(1) Red blood cell assay
The density of erythrocytes in the erythrocyte suspension is adjusted at room temperature, and the OD value of erythrocytes is 1.3000-1.7000 when the erythrocytes are fully hemolyzed at 530 nm. 0.12% was selected as the detection concentration, and the hemolysis rate of erythrocytes was between 60% and 90% when 0.12% of the solution of the product of comparative example 1 was used.
Taking a centrifugal tube, sequentially adding a test object, PBS and RBC suspension according to the table 2, and uniformly mixing, wherein the final concentration of a sample system is the test concentration; placing in a shaking table, incubating for 10min, and centrifuging; observing the phenomenon, taking supernatant, and determining OD 530; the hemolysis rate was calculated.
TABLE 2 reaction system (μ L)
| Addition of reagents | Test sample | PBS | RBC suspensions |
| Sample set | 48 | 252 | 100 |
| Model control group | 300 | 0 | 100 |
| Solvent control group | 0 | 300 | 100 |
The hemolysis rate is calculated as:
erythrocyte hemolysis rate (%) = (OD _ sample group-OD _ solvent control)/(OD _ model control-OD _ solvent control) × 100.
TABLE 3 Effect of samples on the hemolysis rate of erythrocytes
| Sample name | Comparative example 1 | Market contest | Example 1 | PBS |
| Hemolytic rate of erythrocyte% | 70 | 38 | 15 | 0 |
As can be seen from Table 3, the hemolysis rate of erythrocytes was significantly reduced when the 0.12% solution of example 1 was used for the hemolysis test. Experiments prove that the amino acid facial cleanser can effectively reduce irritation.
(2) Chick embryo test
The eggs of the SPF-grade white Lai Hangzhou chicken are fertilized and are fresh, clean and intact, and the mass of the eggs is 50g-60 g. Setting the incubation temperature to be 37.5 +/-0.5 ℃, the relative humidity to be 55-70%, the turntable frequency to be 3-6 times/h, turning over the eggs and incubating for 3 days, and stopping turning over the eggs after windowing on the 4 th day. When the eggs are incubated for 4 days, the eggs should be checked, unfertilized chick embryos are discarded, and broken or thin-shelled chick embryos cannot be used.
After the chick embryos are incubated for 4 days, the small end of the egg is punched with an electric grinder, 2-3mL of egg white is extracted with a 10mL syringe, a small window of 1cm by 1cm is made in the middle of the egg slightly near the large end using the electric grinder to expose the chorioallantoic membrane (CAM) of the chick embryos, and the eggshell and eggshell membrane are carefully removed with forceps. The structure of the vascular system and the growth of the chick embryos should be observed at this time. Sealing the hole at the small end and the small window at the middle part with transparent adhesive tape, and placing the sealed small window into an incubator for continuous culture. The growth condition of the chick embryos needs to be checked every day, and dead embryos are discarded in time. 10 day old chick embryos were used for the experiment. The transparent adhesive tape for sealing the small window is torn off, the area of the small window is enlarged by using tweezers, the observation visual field is enlarged, and the operation is careful without damaging the integrity of the egg membrane. The structure of the vascular system should be observed again at this point and a decision made as to its integrity and suitability for testing. The teflon ring was placed on the CAM to prepare for sample addition.
Each test subject was used as a group, and 6 chick embryos were tested in each group, and 40. mu.l of the test subject was applied directly to the surface of the CAM in the Teflon ring. After 30min at 37 ℃, the change of chorioallantoic membrane toxicity effect indexes (such as bleeding, angiolysis, coagulation and the like) is observed, and the Endpoint Score (ES) is calculated in a combined manner. And comparing the endpoint scores of the test object treatment groups with the endpoint scores of the negative control, wherein the lower the endpoint score of the sample is, the stronger the anti-stimulation effect of the test object is prompted.
TABLE 4 Effect of samples on chick embryo chorioallantoic Membrane stimulation fraction
| Sample name | 4% comparative example 1 | 4% of the commercial competitive products | 4% example 1 | Physiological saline |
| Chick embryo stimulation fraction (ES) | 21.0 | 17.5 | 12.0 | 0 |
As can be seen from Table 4, the cleansing milk of example 1 reduced the irritation to the allantoic membrane of chicken embryo villi.
The experiments prove that the amino acid facial cleanser disclosed by the invention can effectively reduce irritation.
(II) relieving dryness
60 volunteers were selected and divided into 3 groups of 20 persons, and the test was performed using comparative example 1, example 1 and a commercial auction. After the skin is moistened by a tester by using clear water, a proper amount of test product is taken from the palm of the hand, and after foams are slightly kneaded out, the test product is applied to the face and the skin of the face is slightly kneaded for 30 s; then rinsed clean with clear water and used for 2 weeks for each sample. The testers scored according to their own feelings. The scoring criteria were set at 10 points, see table 5 for scoring criteria, and the results of the mean values are shown in table 6 below.
TABLE 5 evaluation criteria
| Weak (weak) | Is weaker | Medium and high grade | Is stronger | High strength | |
| Cleaning power | 0.00-2.00 | 2.00-4.00 | 4.00-6.00 | 6.00-8.00 | 8.00-10.00 |
| Dry and astringent after washing | 0.00-2.00 | 2.00-4.00 | 4.00-6.00 | 6.00-8.00 | 8.00-10.00 |
| Degree of moistening after drying | 0.00-2.00 | 2.00-4.00 | 4.00-6.00 | 6.00-8.00 | 8.00-10.00 |
| Amount of foam | 0.00-2.00 | 2.00-4.00 | 4.00-6.00 | 6.00-8.00 | 8.00-10.00 |
TABLE 6 evaluation of post-wash feel of test products
| Comparative example 1 | Example 1 | Market contest | |
| Cleaning power | 9.00 | 9.10 | 9.05 |
| Dry and astringent after washing | 8.75 | 6.65 | 7.45 |
| Degree of moistening after drying | 7.05 | 8.45 | 7.30 |
| Amount of foam | 8.95 | 9.00 | 8.90 |
As can be seen from Table 6, the cleansing milk of example 1 had a rich foam content, and was able to alleviate the astringent feeling after washing while maintaining good cleansing power, and had a certain degree of moisturization after drying.
The experiments prove that the amino acid facial cleanser disclosed by the invention can relieve the dry and unsmooth feeling after washing and enhance the moistening degree after drying.
Claims (11)
1. An amino acid facial cleanser, comprising: an amino acid surfactant, a polyol, an anti-irritant composition comprising peach gum extract and optionally cactus extract, a preservative and water.
2. The facial cleanser according to claim 1, wherein the average polysaccharide molecular weight of the peach gum polysaccharide is 100-500wDa, preferably 200-300wDa, more preferably 240-280 wDa; the peach gum extract contains more than 30% of peach gum polysaccharide, preferably more than 50% of peach gum polysaccharide, and further preferably more than 70% of peach gum polysaccharide.
3. The facial cleanser according to claim 1 or 2, wherein the anti-irritant composition further comprises as component 3) one or more of dextrin, cyclodextrin, methyl cyclodextrin, hydroxypropyl cyclodextrin, trehalose, polyvinylpyrrolidone, methyl cellulose, methylhydroxyethyl cellulose, hydroxypropylmethyl cellulose, hydroxyethyl cellulose and hydroxypropyl cellulose.
4. The facial cleanser according to claim 1, wherein the anti-irritation composition comprises peach gum extract and cactus extract, preferably the average polysaccharide molecular weight of peach gum polysaccharide and cactus polysaccharide contained in the anti-irritation composition is 100-.
5. The facial cleanser according to any one of claims 1 to 4, wherein the anti-irritant composition is prepared by a preparation method comprising the following steps:
(1) extracting peach gum and optional radix Clematidis with water to obtain primary extractive solution, preferably at 50-90 deg.C for 0.5-5 hr;
(2) and centrifuging the primary extract to obtain a supernatant.
6. The facial cleanser according to claim 5, wherein the weight ratio of peach gum to cactus in step (1) is 1: 5-15: 1, preferably 1: 10-10: 1.
7. the facial cleanser according to claim 5 or 6, wherein the weight ratio of the total weight of the peach gum and the cactus to the water in the step (1) is 1: 10-1: 50.
8. the facial cleanser according to any one of claims 5 to 7, wherein the preparation method of the anti-irritant composition further comprises the step (3): and (3) carrying out microfiltration on the supernatant obtained in the step (2) by adopting a microfiltration membrane module to obtain a micro-filtrate, preferably, the microfiltration membrane module is selected from a ceramic microfiltration membrane module or a roll-type microfiltration membrane module, more preferably, the pore diameter of the microfiltration membrane module is 50-200nm, and more preferably 100 nm.
9. The facial cleanser according to claim 8, wherein the method for preparing said anti-irritant composition further comprises the step (4): and (3) compounding the micro-filtrate obtained in the step (3) with one or more of dextrin, cyclodextrin, methyl cyclodextrin, hydroxypropyl cyclodextrin, trehalose, polyvinylpyrrolidone, methyl cellulose, methyl hydroxyethyl cellulose, hydroxypropyl methyl cellulose, hydroxyethyl cellulose or hydroxypropyl cellulose to obtain a compound, preferably, the weight ratio of the micro-filtrate to one or more of dextrin, cyclodextrin, methyl cyclodextrin, hydroxypropyl cyclodextrin, trehalose, polyvinylpyrrolidone, methyl cellulose, methyl hydroxyethyl cellulose, hydroxypropyl methyl cellulose, hydroxyethyl cellulose or hydroxypropyl cellulose is 1: 1-1: 20.
10. the facial cleanser according to any one of claims 1 to 9, wherein the amino acid surfactant is one or more of potassium cocoyl glycinate, sodium cocoyl taurate, sodium cocoyl alanine, sodium myristoyl sarcosinate or sodium cocoyl glutamate; and/or the polyol is one or more of glycerol, propylene glycol or dipropylene glycol.
11. The facial cleanser according to claim 10, wherein the facial cleanser further comprises one or more of a cationic conditioner, a thickener, an emulsifier, a pearlizing agent, PEG-7 glyceryl cocoate, a pH regulator, sodium chloride and a essence; preferably, the dosage of each component of the facial cleanser is as follows: 10.00-40.00wt% of amino acid surfactant, 5.00-30.00wt% of polyalcohol, 0.00-0.50wt% of cationic conditioner, 0.00-8.00wt% of thickening agent, 0.00-3.00 wt% of PEG-7 glycerol cocoate, 0.00-6.00 wt% of emulsifier, 0.00-3.00 wt% of pearling agent, 0.00-2.00 wt% of pH regulator, 0.00-2.00 wt% of sodium chloride, 0.01-5.00 wt% of anti-irritation composition, 0.05-1.00 wt% of preservative and 0.00-1.00 wt% of essence.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111032185.0A CN113925804A (en) | 2021-09-03 | 2021-09-03 | Amino acid facial cleanser |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111032185.0A CN113925804A (en) | 2021-09-03 | 2021-09-03 | Amino acid facial cleanser |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113925804A true CN113925804A (en) | 2022-01-14 |
Family
ID=79274987
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111032185.0A Pending CN113925804A (en) | 2021-09-03 | 2021-09-03 | Amino acid facial cleanser |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113925804A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114903834A (en) * | 2022-06-30 | 2022-08-16 | 羽楠(广州)化妆品有限公司 | Cold-storable mild double-tube facial cleanser and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105832572A (en) * | 2016-04-07 | 2016-08-10 | 广州宏度精细化工有限公司 | Amino acid facial cleanser and preparation method thereof |
| JP2018104390A (en) * | 2016-12-28 | 2018-07-05 | ポーラ化成工業株式会社 | Cleansing composition |
| CN113018225A (en) * | 2019-12-25 | 2021-06-25 | 太和康美(北京)中医研究院有限公司 | Low-irritation facial cleanser |
| CN113018224A (en) * | 2019-12-25 | 2021-06-25 | 太和康美(北京)中医研究院有限公司 | Anti-irritation composition and application thereof |
| CN113041193A (en) * | 2021-03-26 | 2021-06-29 | 北京东方淼森生物科技有限公司 | Anti-irritation composition and preparation method and application thereof |
-
2021
- 2021-09-03 CN CN202111032185.0A patent/CN113925804A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105832572A (en) * | 2016-04-07 | 2016-08-10 | 广州宏度精细化工有限公司 | Amino acid facial cleanser and preparation method thereof |
| JP2018104390A (en) * | 2016-12-28 | 2018-07-05 | ポーラ化成工業株式会社 | Cleansing composition |
| CN113018225A (en) * | 2019-12-25 | 2021-06-25 | 太和康美(北京)中医研究院有限公司 | Low-irritation facial cleanser |
| CN113018224A (en) * | 2019-12-25 | 2021-06-25 | 太和康美(北京)中医研究院有限公司 | Anti-irritation composition and application thereof |
| CN113041193A (en) * | 2021-03-26 | 2021-06-29 | 北京东方淼森生物科技有限公司 | Anti-irritation composition and preparation method and application thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114903834A (en) * | 2022-06-30 | 2022-08-16 | 羽楠(广州)化妆品有限公司 | Cold-storable mild double-tube facial cleanser and preparation method thereof |
| CN114903834B (en) * | 2022-06-30 | 2024-05-14 | 羽楠(广州)化妆品有限公司 | Cold-storable mild double-tube facial cleanser and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN113018225B (en) | Low-irritation facial cleanser | |
| KR101921211B1 (en) | Cosmetic composition for skin regeneration comprising Ainsliaea acerifolia extract or its fraction as effective component | |
| CN111920732B (en) | Mite-killing conditioner, shampoo and preparation method thereof | |
| JP7213307B2 (en) | Composition for activating protein L-isoaspartate methyltransferase | |
| CN103845273A (en) | Lumbricus peptide capable of resisting skin aging as well as preparation method and application thereof | |
| JP2024510767A (en) | Anti-irritant composition and its manufacturing method and application | |
| CN113018224A (en) | Anti-irritation composition and application thereof | |
| CN112754956A (en) | Formula and preparation method of cactus polysaccharide anti-inflammatory moisturizing mask | |
| CN108309866B (en) | Adult shower gel containing licorice extract | |
| CN113925804A (en) | Amino acid facial cleanser | |
| CN109316419B (en) | Plant composition fermentation raw stock for balancing skin micro-ecology and preparation and application thereof | |
| CN116120420A (en) | Bird's nest polypeptide composition, preparation method thereof and application thereof in anti-aging and whitening | |
| CN109010193A (en) | A kind of Pudilan shower cream and preparation method thereof | |
| CN113908088A (en) | Liquid shampoo | |
| CN110613663A (en) | Skin repairing composition, skin care product and preparation method thereof | |
| CN109602676A (en) | A kind of combination and its preparation process of vegetable soda antiallergic element | |
| CN106727255B (en) | Shampoo containing natural surfactant and preparation method thereof | |
| CN113952265A (en) | Shower gel | |
| CN113712864A (en) | Soap-based facial cleanser | |
| CN111265443A (en) | Anti-aging essence skin care lotion containing codonopsis pilosula extract and preparation method of anti-aging essence skin care lotion | |
| CN117281762B (en) | High-performance skin care composition and preparation method and application thereof | |
| CN117281761B (en) | Amino acid composition for promoting expression of aquaporin 3, application and daily chemical product | |
| CN117695176A (en) | Process for preparing tremella extract by fermentation method and composition containing tremella extract | |
| JPH06128140A (en) | External agent for skin | |
| CN116725895A (en) | Collagen liquid and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20220114 |