CN109010193A - A kind of Pudilan shower cream and preparation method thereof - Google Patents
A kind of Pudilan shower cream and preparation method thereof Download PDFInfo
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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Abstract
The invention discloses a kind of Pudilan shower creams, are prepared from the following parts by weight of the components: 0.1-6 parts of Pudilan extract, 0.02-2 parts of Baical Skullcap root P.E, 0.02-2 parts of shrubby sophora extract, 0.02-2 parts of ginseng extract, 0.02-2 parts of patchouli oil, 0.04-3 parts of jojoba oil, 71-135 parts of auxiliary material.The invention also discloses the preparation methods of above-mentioned Pudilan shower cream.The present invention, which has, dispels skin surface dirt, mitigates the function of skin burden；Also there is significant bacterio static itching-relieving effect, protect the skin from the infringement of pathogen；There is auxiliary improvement result to the acne of limbs and thoracic dorsal, useless fellow, scabies, dermatitis etc.；And preparation process is simple, and easy to operate feature is conducive to the industrialization production of Pudilan shower cream.
Description
Technical field
The present invention relates to daily cleaning nursing materials fields more particularly to a kind of Pudilan shower cream and preparation method thereof.
Background technique
Skin is the maximum tissue of human body, is covered on the surface of human body, constitutes one natural physics and immunization barrier,
Protect human body from extraneous injury.It is influenced by global environment deterioration, pathogen that people touch in daily life has
The pollutant that malicious harmful substance gradually increases, and stops on skin surface, grease, the sweat etc. of skin itself secretion, also gives
The chance that various pathogens grow in skin surface, is easy to cause skin itch problem occur, increases the burden of skin.With
The improvement of people's living standards, people are higher and higher to the attention degree of health, and people use shower cream removal skin surface
The demand of pathogen, grease and sweat is further strong, and for shower cream at necessary articles for daily use in for people's lives, market is on sale
Shower cream it is dazzling, but effect is indefinite, or only has effects that cleaning.
Moreover, the commercially available shower cream product overwhelming majority be not it is pure natural, formula in be added to a large amount of chemicals
Matter, these chemical substances are easy to pollute to water resource from petrochemical industry raw material or by artificial synthesized, and
Shower cream containing numerous chemical substances frequently and skin contact, is easy to generate adverse effect to skin, even human body, because its
Contain the harmful substances such as carcinogenic benzene, aldehyde.In the past, herbal medicine immersion, cleaning body are often used in traditional Chinese medicine traditional remedies,
To achieve the purpose that treat dermatopathy, describe in " Li Yue Pianwen, Rhymed Discourse for Topical Remedies " of Qing Dynasty's Wu Shi machine including applying, smoking, soak, wash, wipe
Tens of kinds of outer treating methods, to treat dermatopathy and interior, woman, youngster, outer, the various illness of five official ranks.China's natural resources of Chinese medicinal materials is rich
Richness, simultaneously as the progress of bioscience technology, by Chinese herbal medicine formula connected applications in daily chemical product, it has also become future
The development trend of daily chemical product embodies the advantage of traditional Chinese medicine traditional theory, and the performance of Chinese medicine is mild, stingless to skin
Swash property, skin can be realized and be effectively protected.
Summary of the invention
For overcome the deficiencies in the prior art, one of the objects of the present invention is to provide a kind of Pudilan shower creams, it has
Skin surface dirt is dispelled, the function of skin burden is mitigated；Also there is significant bacterio static itching-relieving effect, protect the skin from disease
The infringement of opportunistic pathogen；There is auxiliary improvement result to the acne of limbs and thoracic dorsal, useless fellow, scabies, dermatitis etc..
The second object of the present invention is to provide the preparation method of the Pudilan shower cream containing an object of the present invention, should
Preparation method has simple process, and easy to operate feature is conducive to the industrialization production of shower cream.
An object of the present invention adopts the following technical scheme that realization:
A kind of Pudilan shower cream, which is characterized in that be prepared from the following parts by weight of the components:
0.1-6 parts of Pudilan extract, 0.02-2 parts of Baical Skullcap root P.E, 0.02-2 parts of shrubby sophora extract, ginseng extract
0.02-2 parts, 0.02-2 parts of patchouli oil, 0.04-3 parts of jojoba oil, 71-135 parts of auxiliary material.
Further, the auxiliary material comprises the following components in parts by weight component:
8-16 parts of laureth sodium sulfovinate, 1-5 parts of laurel alcohol sulfuric ester ammonium, 2-8 parts of monomester succinate disodium salt, coconut palm
0.3-2 parts of oleamide diethanol amine, 5-15 parts of CAB-35 glycine betaine, 1-4 parts of Sodium Lauroamphoacetate, certain herbaceous plants with big flowers base glucoside 1-
3 parts, 1-3 parts of pyrrolidone sodium carboxylate, -7 0.2-1.2 parts of polyquaternium, 0.1-1 parts of vitamin E, EDTA-2Na0.05-2 parts,
1-3 parts of glycerol, 0.2-1 parts of D-pantothenyl aleohol, 0.05-2 parts of Kathon, 0.1-1 parts of essence, 0.05-2 parts of sodium chloride, deionized water 50-65
Part.
Further, it is prepared from the following parts by weight of the components:
It is 0.6 part of Pudilan extract, 0.1 part of Baical Skullcap root P.E, 0.1 part of shrubby sophora extract, 0.1 part of ginseng extract, wide
0.1 part of palchouli oil, 0.2 part of jojoba oil, 12 parts of laureth sodium sulfovinate, 3.5 parts of laurel alcohol sulfuric ester ammonium, mono succinate
4 parts of ester disodium salt, 0.7 part of cocamide diethanolamine, 10 parts of CAB-35 glycine betaine, 2 parts of Sodium Lauroamphoacetate, certain herbaceous plants with big flowers base
2 parts of glucoside, 2 parts of pyrrolidone sodium carboxylate, 0.7 part of polyquaternium -7,0.4 part of vitamin E, EDTA-2Na0.1 parts, glycerol 2
Part, 0.5 part of D-pantothenyl aleohol, 0.1 part of Kathon, 0.3 part of essence, 0.15 part of sodium chloride, 58.85 parts of deionized water.
Further, the Pudilan extract is prepared by the component of following parts by weight: 20-60 parts of dandelion,
10-20 parts of viola mandshurica, 10-20 parts of Radix Isatidis.
Further, the Pudilan extract is prepared by the component of following parts by weight: 45 parts of dandelion, pale reddish brown
11.25 parts of Chinese violet, 16.9 parts of Radix Isatidis.
Further, the Pudilan extract the preparation method comprises the following steps: weighing the dandelion of formula ratio, viola mandshurica and plate
Lan Gen adds 12 times of amount drinking water to decoct 2 times, 2 hours every time, filters；It is 1.05 that merging filtrate, which is concentrated into relative density, is centrifuged dense
Contracting is to get Pudilan extract.
The second object of the present invention adopts the following technical scheme that realization:
The preparation method of the Pudilan shower cream of one of the object of the invention, which comprises the following steps:
The step of preparing mixture A: weighing the Baical Skullcap root P.E and Pudilan extract of formula ratio, and deionized water 5- is added
15ml, dissolution, filtering；Remaining deionized water is added, is heated to 50-80 DEG C；The laureth sulfuric ester of formula ratio is added
Sodium, laurel alcohol sulfuric ester ammonium, monomester succinate disodium salt, cocamide diethanolamine and EDTA-2Na, stirring and dissolving are mixed
Close object A；
The step of preparing mixture B: the CAB-35 glycine betaine, certain herbaceous plants with big flowers base glucoside, lauroyl both sexes guanidine-acetic acid of formula ratio are taken
Sodium, polyquaternium -7 and pyrrolidone sodium carboxylate are added in mixture A, stop heating, stir evenly, be cooled to 20-45 DEG C,
Obtain mixture B；
The step of preparing Pudilan shower cream finished product: shrubby sophora extract, the ginseng of formula ratio are sequentially added in mixture B
Extract, patchouli oil, jojoba oil, vitamin E, glycerol, D-pantothenyl aleohol, Kathon and essence；It stirs evenly, places complete to bubble
After totally disappeared mistake, sodium chloride is added, is adjusted to required viscosity；Up to Pudilan shower cream finished product.
Further, in described the step of preparing mixture A, the temperature of heating is 60 DEG C.
Further, in described the step of preparing mixture B, 30 DEG C are cooled to.
Further, in described the step of preparing Pudilan shower cream finished product, viscosity is adjusted to 6000cps.
Compared with prior art, the beneficial effects of the present invention are:
1, shower cream of the invention is effectively compounded by plurality of Chinese, passes through Pudilan extract, shrubby sophora extract, Huang
A kind of reed mentioned in ancient books extract and patchouli oil synergistic effect play powerful bacterio static itching-relieving effect, then total with jojoba oil and ginseng extract
Same-action, realize skin moisturizing, moist, compact and whitening the effect of.
2, shower cream of the invention passes through Pudilan extract, Baical Skullcap root P.E, shrubby sophora extract, ginseng extract, suddenly
The reasonable compounding of bar oil and patchouli oil suddenly, additionally it is possible to adjust the metabolism of cuticula, reduce sebum secretion；Kohakuhi,
Soft and moist skin；It protects skin and mucosa from bacterial infestation, there is auxiliary improvement result to useless fellow, scabies, dermatitis etc., it is especially right
Acne improvement result on limbs, thoracic dorsal is obvious.Moreover, natural environmental-protective, have no toxic side effect, it is mild comfortable, non-stimulated to skin,
Securely and reliably, the injury that can effectively avoid pathogen to human body, maintenance human health is used for a long time.
3, the preparation method of shower cream provided by the invention can sufficiently extract and protect Pudilan extract, radix scutellariae to extract
Biologically active effective component in object, shrubby sophora extract, ginseng extract, jojoba oil and patchouli oil, it is ensured that take a shower
Effective component in dew can give full play to the effect of bacterio static itching-relieving, to solve the problems, such as pruitus；And the preparation side
Method has simple process, and easy to operate feature is conducive to industrialization production.
Detailed description of the invention
Fig. 1 is the result figure of No. 12 culture mediums in escherichia coli test；
Fig. 2 from left to right, is followed successively by the result figure of the 1-10 culture medium in escherichia coli test from top to bottom；
Fig. 3 is the result figure of No. 12 culture mediums in staphylococcus aureus test；
Fig. 4 from left to right, is followed successively by the result figure of the 1-6 culture medium in staphylococcus aureus test from top to bottom；
Fig. 5 is from left to right followed successively by the result figure of the 10-11 culture medium in staphylococcus aureus test；
Fig. 6 is the result figure of No. 12 culture mediums in Candida albicans test；
Fig. 7 from left to right, is followed successively by the result figure of the 1-10 culture medium in Candida albicans test from top to bottom.
Specific embodiment
In the following, being described further in conjunction with specific embodiment to the present invention, it should be noted that is do not collided
Under the premise of, new embodiment can be formed between various embodiments described below or between each technical characteristic in any combination.It is adopted
Equipment and raw material etc. are commercially available or commonly used in the art.Method in following embodiments, such as nothing are especially said
It is bright, it is the conventional method of this field.
A kind of Pudilan shower cream, is prepared from the following parts by weight of the components:
0.1-6 parts of Pudilan extract, 0.02-2 parts of Baical Skullcap root P.E, 0.02-2 parts of shrubby sophora extract, ginseng extract
0.02-2 parts, 0.02-2 parts of patchouli oil, 0.04-3 parts of jojoba oil, 71-135 parts of auxiliary material.
Wherein, Pudilan extract is to extract and obtain from 3 kinds of medicinal materials such as dandelion, viola mandshurica, Radix Isatidis；With clear
The effect of thermal detoxification, anti-inflammation detumescence.
Shrubby sophora extract is the alkaloid extracted from kuh-seng by conventional extractive technique.Kuh-seng, it is cold in nature, there is heat-clearing dry
It is wet, the effect of desinsection.Kuh-seng shower can remove damp-heat in lower-JIAO, and desinsection is antipruritic, have to alleviate well to pruitus and make
With.
Ginseng extract is to be extracted from the root of ginseng by conventional technology.Ginseng extract is rich in ginseng soap
Glycosides has the effects that enhance the vigor of human body surface cell, inhibits skin aging.
Effective component in patchouli oil includes the structure of patchoulene, has effects that antibacterial, anti-inflammatory.Meanwhile extensively
Ageratum oil is good fixastive, and being added in shower cream can allow the fragrance of shower cream more longlasting with patchouli oil.
Jojoba oil contains the important natural vitamin of skin and collagenic protein, skin-nourishing, and skin gloss is made to have bullet
Property.
Dandelion herb contains taraxasterol, choline, synanthrin, caffeic acid, pectin, taraxol, β-amyrin, beans steroid
Alcohol, cupreol, taraxerol, taraxacin, taraxacin and vitamin A, B, C etc..Wherein, dandelion it is effective at
Divide includes caffeic acid and Cichoric acid；Dandelion has clearing heat and detoxicating, the effect of diuresis dissipating bind.
Radix Isatidis contains indigo, indigo red, Anthraquinones, cupreol, clionasterol and a variety of amino acid: arginine, paddy
Propylhomoserin, tyrosine, proline, valine, γ-aminobutyric acid；Also contain potassium myronate, indigo, couroupitine A, 1- thiocyanic acid -2- hydroxyl
Base butyl- 3- alkene, gland glucoside, palmitinic acid, sucrose and the proteoglycan containing 12% amino acid.Radix Isatidis has clearing heat and detoxicating, cool blood,
Relieving sore-throat, antiviral effect.
Viola mandshurica is the drying herb of violaceae plant viola mandshurica.
Baical Skullcap root P.E the preparation method comprises the following steps: weigh the radix scutellariae of formula ratio, add 60% ethyl alcohol to be heated to reflux 3 times, 2 is small every time
When, filtering；It is 1.05 that merging filtrate recycling ethyl alcohol, which is concentrated into relative density, and centrifugal concentrating is to get Baical Skullcap root P.E.
Radix scutellariae mainly contains flavone compound: scutelloside is the principle active component of radix scutellariae, molecular formula C21H18O11, point
Son amount be 446.35, be yellow crystal, 223 DEG C of fusing point；Radix scutellariae has the effect of antimicrobial antiphlogistic, heat-clearing and damp-drying drug, purging fire for removing toxin；
As further embodiment, auxiliary material comprises the following components in parts by weight component:
8-16 parts of laureth sodium sulfovinate, 1-5 parts of laurel alcohol sulfuric ester ammonium, 2-8 parts of monomester succinate disodium salt, coconut palm
0.3-2 parts of oleamide diethanol amine, 5-15 parts of CAB-35 glycine betaine, 1-4 parts of Sodium Lauroamphoacetate, certain herbaceous plants with big flowers base glucoside 1-
3 parts, 1-3 parts of pyrrolidone sodium carboxylate, -7 0.2-1.2 parts of polyquaternium, 0.1-1 parts of vitamin E, EDTA-2Na0.05-2 parts,
1-3 parts of glycerol, 0.2-1 parts of D-pantothenyl aleohol, 0.05-2 parts of Kathon, 0.1-1 parts of essence, 0.05-2 parts of sodium chloride, deionized water 50-65
Part.
As further embodiment, it is prepared from the following parts by weight of the components:
It is 0.6 part of Pudilan extract, 0.1 part of Baical Skullcap root P.E, 0.1 part of shrubby sophora extract, 0.1 part of ginseng extract, wide
0.1 part of palchouli oil, 0.2 part of jojoba oil, 12 parts of laureth sodium sulfovinate, 3.5 parts of laurel alcohol sulfuric ester ammonium, mono succinate
4 parts of ester disodium salt, 0.7 part of cocamide diethanolamine, 10 parts of CAB-35 glycine betaine, 2 parts of Sodium Lauroamphoacetate, certain herbaceous plants with big flowers base
2 parts of glucoside, 2 parts of pyrrolidone sodium carboxylate, 0.7 part of polyquaternium -7,0.4 part of vitamin E, EDTA-2Na0.1 parts, glycerol 2
Part, 0.5 part of D-pantothenyl aleohol, 0.1 part of Kathon, 0.3 part of essence, 0.15 part of sodium chloride, 58.85 parts of deionized water.
As further embodiment, Pudilan extract is prepared by the component of following parts by weight: dandelion
20-60 parts, 10-20 parts of viola mandshurica, 10-20 parts of Radix Isatidis.
As further embodiment, Pudilan extract is prepared by the component of following parts by weight: dandelion
45 parts, 11.25 parts of viola mandshurica, 16.9 parts of Radix Isatidis.
As further embodiment, Pudilan extract the preparation method comprises the following steps: weighing the dandelion of formula ratio, pale reddish brown
Chinese violet and Radix Isatidis add 12 times of amount drinking water to decoct 2 times, 2 hours every time, filter；Merging filtrate is concentrated into relative density
1.05, centrifugal concentrating is to get Pudilan extract.
The preparation method of above-mentioned Pudilan shower cream, comprising the following steps:
The step of preparing mixture A: weighing the Baical Skullcap root P.E and Pudilan extract of formula ratio, and deionized water 5- is added
15ml, dissolution, filtering；Remaining deionized water is added, is heated to 50-80 DEG C；The laureth sulfuric ester of formula ratio is added
Sodium, laurel alcohol sulfuric ester ammonium, monomester succinate disodium salt, cocamide diethanolamine and EDTA-2Na, stirring and dissolving are mixed
Close object A；
The step of preparing mixture B: the CAB-35 glycine betaine, certain herbaceous plants with big flowers base glucoside, lauroyl both sexes guanidine-acetic acid of formula ratio are taken
Sodium, polyquaternium -7 and pyrrolidone sodium carboxylate are added in mixture A, stop heating, stir evenly, be cooled to 20-45 DEG C,
Obtain mixture B；
The step of preparing Pudilan shower cream finished product: shrubby sophora extract, the ginseng of formula ratio are sequentially added in mixture B
Extract, patchouli oil, jojoba oil, vitamin E, glycerol, D-pantothenyl aleohol, Kathon and essence；It stirs evenly, places complete to bubble
After totally disappeared mistake, sodium chloride is added, is adjusted to required viscosity；Up to Pudilan shower cream finished product.
As further embodiment, in the step of preparing mixture A, the temperature of heating is 60 DEG C.
As further embodiment, in the step of preparing mixture B, it is cooled to 30 DEG C.
As further embodiment, in the step of preparing Pudilan shower cream finished product, viscosity is adjusted to 6000cps.
Embodiment 1-3:
A kind of Pudilan shower cream, is prepared from the following components:
Pudilan extract, Baical Skullcap root P.E, shrubby sophora extract, ginseng extract, patchouli oil, jojoba oil, laurel
Alcohol polyethers sodium sulfovinate, laurel alcohol sulfuric ester ammonium, monomester succinate disodium salt, cocamide diethanolamine, CAB-35 glycine betaine,
It is Sodium Lauroamphoacetate, certain herbaceous plants with big flowers base glucoside, pyrrolidone sodium carboxylate, polyquaternium -7, vitamin E, EDTA-2Na, sweet
Oil, D-pantothenyl aleohol, Kathon, essence, sodium chloride, deionized water.
Wherein, Pudilan extract the preparation method comprises the following steps: weighing 45 parts of dandelion, 11.25 parts of viola mandshurica and Radix Isatidis
16.9 parts, adds 12 times of amount drinking water to decoct 2 times, 2 hours every time, filter；It is 1.05 that merging filtrate, which is concentrated into relative density, centrifugation
Concentration is to get Pudilan extract.
The content (calculating by weight) of Pudilan shower cream each component is shown in Table 1.
The content of the Pudilan shower cream each component of 1 embodiment 1-3 of table:
The preparation method of above-mentioned Pudilan shower cream, comprising the following steps:
The step of preparing mixture A: weighing the Baical Skullcap root P.E and Pudilan extract of formula ratio, and deionized water is added
10ml, dissolution, filtering；Remaining deionized water is added, is heated to 60 DEG C；The laureth sodium sulfovinate of addition formula ratio,
Laurel alcohol sulfuric ester ammonium, monomester succinate disodium salt, cocamide diethanolamine and EDTA-2Na, stirring and dissolving are mixed
Object A；
The step of preparing mixture B: the CAB-35 glycine betaine, certain herbaceous plants with big flowers base glucoside, lauroyl both sexes guanidine-acetic acid of formula ratio are taken
Sodium, polyquaternium -7 and pyrrolidone sodium carboxylate are added in mixture A, stop heating, stir evenly, be cooled to 30 DEG C, obtain
Mixture B；
The step of preparing Pudilan shower cream finished product: shrubby sophora extract, the ginseng of formula ratio are sequentially added in mixture B
Extract, patchouli oil, jojoba oil, vitamin E, glycerol, D-pantothenyl aleohol, Kathon and essence；It stirs evenly, places complete to bubble
After totally disappeared mistake, sodium chloride is added, being adjusted to viscosity is 6000cps；Up to Pudilan shower cream finished product.
Verify embodiment:
Pudilan shower cream prepared by testing example 2 is to escherichia coli, staphylococcus aureus and Candida albicans
Fungistatic effect, pass through the beneficial effect of the following tests Pudilan shower cream described come the present invention is further explained.
1 test strain:
Escherichia coli CMCC (B) 44102；Staphylococcus aureus CMCC (B) 26003；Candida albicans (read by white
Pearl bacterium) CMCC (F) 98001；Three of the above bacterial strain is purchased from Huankai Microbes Tech Co., Ltd., Guangdong.
2 test reagents:
Silica, sorbierite, deionized water, glycerine, polyethylene glycol-400, K-12 powder, essence, xanthan gum, hydroxyl second
It is base cellulose, sodium monofluorophosphate, saccharin sodium, menthol, peppermint oil, sodium benzoate, 1% brilliant blue solution, methanol, phosphoric acid, sterile
Physiological saline, agar powder.
3 test culture mediums:
LB nutrient agar (LB Nutrient Agar) 250g；Columbia blood agar base (improvement) (Modified
Columbia Blood Agar Base)250g；MH meat soup (MH Broth) 250g.
4 test apparatuses:
Electric blender (Changzhou Guo Yu instrument manufacturing Co., Ltd), KH-100DE type numerical control ultrasonic cleaner (Kunshan
He Chuan ultrasonic instrument Co., Ltd), Centrifuge 5804R (Guangzhou He Zhong Biotechnology Co., Ltd), Agilent1290
(Agilent company of the U.S.), UV2PCR Workstation (UVP), insulating box, bacterial cultures bacterium operating room (Chinese materia medica preparation
Teaching and research room provides), high steam pot, 10 μ l oeses etc..
5 test methods and result
The bacteriostatic test of 5.1 pairs of escherichia coli:
5.1.1 the preparation of the matrix of shower cream containing Pudilan:
Accurate measuring 4.0gLB nutrient agar after adding 100ml distilled water to dissolve by heating, is added in clean triangular flask
1.5g agar powder, until completely dissolved, 121 DEG C of high pressure sterilization 15min are spare.
The shower cream 5.0g of Example 2 is placed in the beaker of clean sterilizing, 10mL sterile saline is added, with cleaning
Glass bar be stirred until homogeneous dispersion, as shower cream stoste, concentration 0.5g/mL.Take the test tube of 12 clean sterilizings, label
1-12.Shower cream stoste 5mL is measured in No. 1 test tube and No. 2 test tubes, No. 2 test tubes are carried out to dilute again with sterile saline
It releases, is made into the dilution of 1:2；It takes 5mL liquid in No. 3 test tubes from No. 2 test tubes, carries out two-fold dilution, be configured to the dilute of 1:4
Release liquid, and so on, 1-11 test tube be successively configured to 1:1,1:2,1:4,1:8,1:16,1:32,1:64,1:128,1:256,
The dilution of 1:512,1:1024, No. 12 test tube is sterile saline, as blank control.
It takes above-mentioned test solution 1ml in the culture dish of cleaning sterilizing, is uniformly mixed with agar solution with the ratio of 1:9, number point
Not Wei 1~12, be cooled to solidification.By the culture medium solidified sealing, it is inverted in overnight incubation in 37 DEG C of insulating box, is observed
Whether living contaminants are had.
5.1.2 it is inoculated with:
On inspection, all culture mediums are dilute by escherichia coli freeze-dried powder sterile saline not by living contaminants
It releases, using plate streak, takes bacterium solution to be inoculated on each culture medium with the aseptic inoculation ring that inoculum concentration is 10ul.It is placed in
Bacterial growth situation is observed after cultivating 24 hours in 37 DEG C of insulating box, is compared with blank control, and whether there is or not bacterium lifes for observation
It is long, using the minimum diluted concentration of no bacterial growth as minimal inhibitory concentration, i.e. MIC.
5.1.3 test result:
All culture dishes have different degrees of bacterium colony growth, wherein the clump count in 1-2 culture dish is considerably less than sky
The clump count of No. 12 culture dishes of white control, although can not determine MIC, but it is also possible to find out, the culture of the shower cream containing Pudilan
Base has certain inhibiting effect to escherichia coli；Detailed results are shown in Table 1, and the bacterium colony situation on culture dish is referring to attached drawing 1-2.
The bacteriostatic test of 5.2 pairs of staphylococcus aureuses:
5.2.1 the preparation of the matrix of shower cream containing Pudilan:
Accurate measuring 4.4g Columbia Blood Agar after adding 100ml distilled water to dissolve by heating, adds in clean triangular flask
Enter 1.5g agar powder, until completely dissolved, when being cooled to 50 DEG C or so, the sterile de- fibre of 5ml is added in 121 DEG C of high pressure sterilization 15min
Sheep blood is tieed up, is mixed, it is spare.
The shower cream 5.0g of Example 2 is placed in the beaker of clean sterilizing, 10mL sterile saline is added, with cleaning
Glass bar be stirred until homogeneous dispersion, as shower cream stoste, concentration 0.5g/mL.Take the test tube of 12 clean sterilizings, label
1-12.Shower cream stoste 5mL is measured in No. 1 test tube and No. 2 test tubes, No. 2 test tubes are carried out to dilute again with sterile saline
It releases, is made into the dilution of 1:2；It takes 5mL liquid in No. 3 test tubes from No. 2 test tubes, carries out two-fold dilution, be configured to the dilute of 1:4
Release liquid, and so on, 1-11 test tube be successively configured to 1:1,1:2,1:4,1:8,1:16,1:32,1:64,1:128,1:256,
The dilution of 1:512,1:1024, No. 12 test tube is sterile saline, as blank control.
It takes above-mentioned test solution 1ml in the culture dish of cleaning sterilizing, is uniformly mixed with agar solution with the ratio of 1:9, number point
Not Wei 1~12, be cooled to solidification.By the culture medium solidified sealing, it is inverted in overnight incubation in 37 DEG C of insulating box, is observed
Whether living contaminants are had.
5.2.2 it is inoculated with:
On inspection, all culture mediums dilute staphylococcus aureus with sterile saline not by living contaminants,
Using plate streak, bacterium solution is taken to be inoculated on each culture medium with the aseptic inoculation ring that inoculum concentration is 10ul.It is placed in 37
DEG C insulating box in cultivate 24 hours after observe bacterial growth situation, be compared with blank control, observation whether there is or not bacterial growth,
Using the minimum diluted concentration of no bacterial growth as minimal inhibitory concentration, i.e. MIC.
5.2.3 test result:
All culture dishes have different degrees of bacterium colony growth, the culture medium of the shower cream containing Pudilan and the training of blank control
The clump count of base is supported without significant difference, can not also determine MIC, detailed results are shown in Table 1, and the bacterium colony situation on culture dish is referring to attached drawing
3-5。
The bacteriostatic test of 5.3 pairs of Candida albicans:
5.3.1 the preparation of the matrix of shower cream containing Pudilan:
After adding 100ml distilled water to dissolve by heating, 1.5g fine jade is added in clean triangular flask in accurate measuring 2.1gMH meat soup
Cosmetics, until completely dissolved, 121 DEG C of high pressure sterilization 15min are spare.
The shower cream 5.0g of Example 2 is placed in the beaker of clean sterilizing, 10mL sterile saline is added, with cleaning
Glass bar be stirred until homogeneous dispersion, as shower cream stoste, concentration 0.5g/mL.Take the test tube of 12 clean sterilizings, label
1-12.Shower cream stoste 5mL is measured in No. 1 test tube and No. 2 test tubes, No. 2 test tubes are carried out to dilute again with sterile saline
It releases, is made into the dilution of 1:2；It takes 5mL liquid in No. 3 test tubes from No. 2 test tubes, carries out two-fold dilution, be configured to the dilute of 1:4
Release liquid, and so on, 1-11 test tube be successively configured to 1:1,1:2,1:4,1:8,1:16,1:32,1:64,1:128,1:256,
The dilution of 1:512,1:1024, No. 12 test tube is sterile saline, as blank control.
It takes above-mentioned test solution 1ml in the culture dish of cleaning sterilizing, is uniformly mixed with agar solution with the ratio of 1:9, number point
Not Wei 1~12, be cooled to solidification.By the culture medium solidified sealing, it is inverted in overnight incubation in 37 DEG C of insulating box, is observed
Whether living contaminants are had.
5.3.2 it is inoculated with:
On inspection, all culture mediums are dilute by Candida albicans freeze-dried powder sterile saline not by living contaminants
It releases, using plate streak, takes bacterium solution to be inoculated on each culture medium with the aseptic inoculation ring that inoculum concentration is 10ul.It is placed in
Bacterial growth situation is observed after cultivating 2-3 days in 37 DEG C of insulating box, is compared with blank control, and whether there is or not bacterium lifes for observation
It is long, using the minimum diluted concentration of no bacterial growth as minimal inhibitory concentration, i.e. MIC.
5.3.3 test result:
All culture dishes have different degrees of bacterium colony growth, wherein the clump count in 1-2 culture dish is considerably less than sky
The clump count of No. 12 culture dishes of white control, although can not determine MIC, but it is also possible to find out, the training containing Pudilan shower cream
Supporting base has certain inhibiting effect to Candida albicans；Detailed results are shown in Table 1, and the bacterium colony situation on culture dish is referring to attached drawing 6-
7。
Table 1 is that the bacterium colony of three kinds of bacteriums on 1-12 culture dish situation occurs:
In table 1 ,+: representative has bacterium colony growth；: represent sterile length of being born.
Staphylococcus aureus, escherichia coli, Candida albicans are all common pathogens, and Pudilan shower cream is to upper
Stating three kinds of bacteriums has a degree of inhibiting effect, wherein significant to the inhibitory effect of Candida albicans, escherichia coli.
The above embodiment is only the preferred embodiment of the present invention, and the scope of protection of the present invention is not limited thereto,
The variation for any unsubstantiality that those skilled in the art is done on the basis of the present invention and for belong to the present invention wanted
Seek the range of protection.
Claims (10)
1. a kind of Pudilan shower cream, which is characterized in that be prepared from the following parts by weight of the components:
0.1-6 parts of Pudilan extract, 0.02-2 parts of Baical Skullcap root P.E, 0.02-2 parts of shrubby sophora extract, ginseng extract 0.02-
2 parts, 0.02-2 parts of patchouli oil, 0.04-3 parts of jojoba oil, 71-135 parts of auxiliary material.
2. Pudilan shower cream according to claim 1, which is characterized in that the auxiliary material includes the group of following parts by weight
Point:
8-16 parts of laureth sodium sulfovinate, 1-5 parts of laurel alcohol sulfuric ester ammonium, 2-8 parts of monomester succinate disodium salt, cocounut oil acyl
0.3-2 parts of amine diethanol amine, 5-15 parts of CAB-35 glycine betaine, 1-4 parts of Sodium Lauroamphoacetate, 1-3 parts of certain herbaceous plants with big flowers base glucoside,
1-3 parts of pyrrolidone sodium carboxylate, -7 0.2-1.2 parts of polyquaternium, 0.1-1 parts of vitamin E, EDTA-2Na0.05-2 parts, glycerol
1-3 parts, 0.2-1 parts of D-pantothenyl aleohol, 0.05-2 parts of Kathon, 0.1-1 parts of essence, 0.05-2 parts of sodium chloride, 50-65 parts of deionized water.
3. Pudilan shower cream according to claim 1, which is characterized in that be prepared from the following parts by weight of the components:
0.6 part of Pudilan extract, 0.1 part of Baical Skullcap root P.E, 0.1 part of shrubby sophora extract, 0.1 part of ginseng extract, Pogostemon cablin
Oily 0.1 part, 0.2 part of jojoba oil, 12 parts of laureth sodium sulfovinate, 3.5 parts of laurel alcohol sulfuric ester ammonium, monomester succinate two
4 parts of sodium salt, 0.7 part of cocamide diethanolamine, 10 parts of CAB-35 glycine betaine, 2 parts of Sodium Lauroamphoacetate, certain herbaceous plants with big flowers base glucose
2 parts of glycosides, 2 parts of pyrrolidone sodium carboxylate, 0.7 part of polyquaternium -7,0.4 part of vitamin E, EDTA-2Na0.1 parts, 2 parts of glycerol,
0.5 part of D-pantothenyl aleohol, 0.1 part of Kathon, 0.3 part of essence, 0.15 part of sodium chloride, 58.85 parts of deionized water.
4. Pudilan shower cream according to claim 1, which is characterized in that the Pudilan extract is by following parts by weight
Several components are prepared: 20-60 parts of dandelion, 10-20 parts of viola mandshurica, 10-20 parts of Radix Isatidis.
5. Pudilan shower cream according to claim 4, which is characterized in that the Pudilan extract is by following parts by weight
Several components are prepared: 45 parts of dandelion, 11.25 parts of viola mandshurica, 16.9 parts of Radix Isatidis.
6. Pudilan shower cream according to claim 4, which is characterized in that the preparation method of the Pudilan extract
Are as follows: the dandelion, viola mandshurica and Radix Isatidis for weighing formula ratio add 12 times of amount drinking water to decoct 2 times, 2 hours every time, filter；
It is 1.05 that merging filtrate, which is concentrated into relative density, and centrifugal concentrating is to get Pudilan extract.
7. the preparation method of Pudilan shower cream according to claim 2, which comprises the following steps:
The step of preparing mixture A: weighing the Baical Skullcap root P.E and Pudilan extract of formula ratio, and deionized water 5- is added
15ml, dissolution, filtering；Remaining deionized water is added, is heated to 50-80 DEG C；The laureth sulfuric ester of formula ratio is added
Sodium, laurel alcohol sulfuric ester ammonium, monomester succinate disodium salt, cocamide diethanolamine and EDTA-2Na, stirring and dissolving are mixed
Close object A；
The step of preparing mixture B: it takes the CAB-35 glycine betaine of formula ratio, certain herbaceous plants with big flowers base glucoside, Sodium Lauroamphoacetate, gather
Quaternary ammonium salt -7 and pyrrolidone sodium carboxylate are added in mixture A, stop heating, stir evenly, be cooled to 20-45 DEG C, mixed
Close object B；
The step of preparing Pudilan shower cream finished product: the shrubby sophora extract of formula ratio is sequentially added in mixture B, ginseng extracts
Object, patchouli oil, jojoba oil, vitamin E, glycerol, D-pantothenyl aleohol, Kathon and essence；It stirs evenly, placement disappears completely to bubble
After mistake, sodium chloride is added, is adjusted to required viscosity；Up to Pudilan shower cream finished product.
8. the preparation method of Pudilan shower cream according to claim 7, which is characterized in that described to prepare mixture A's
In step, the temperature of heating is 60 DEG C.
9. the preparation method of Pudilan shower cream according to claim 7, which is characterized in that described to prepare mixture B's
In step, it is cooled to 30 DEG C.
10. the preparation method of Pudilan shower cream according to claim 7, which is characterized in that the Pudilan for preparing is washed one's hair
In the step of bath lotion finished product, viscosity is adjusted to 6000cps.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109675091A (en) * | 2019-01-26 | 2019-04-26 | 湖南博隽生物医药有限公司 | A kind of biological dressing and preparation method thereof for eliminating scar |
| CN110772572A (en) * | 2019-11-29 | 2020-02-11 | 内蒙古自治区国际蒙医医院(内蒙古自治区蒙医药研究所) | Senden-4 lotion and preparation method thereof |
| CN111297746A (en) * | 2019-12-18 | 2020-06-19 | 佛山科学技术学院 | Shower gel and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104983624A (en) * | 2015-06-29 | 2015-10-21 | 南阳市汇博生物技术有限公司 | Repairing skin-protecting nourishing mask impregnation liquid and preparation method thereof |
| CN105434216A (en) * | 2015-11-25 | 2016-03-30 | 济川药业集团有限公司 | Pudilan antibacterial and antipruritic shower gel and preparation method thereof |
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| CN104983624A (en) * | 2015-06-29 | 2015-10-21 | 南阳市汇博生物技术有限公司 | Repairing skin-protecting nourishing mask impregnation liquid and preparation method thereof |
| CN105434216A (en) * | 2015-11-25 | 2016-03-30 | 济川药业集团有限公司 | Pudilan antibacterial and antipruritic shower gel and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109675091A (en) * | 2019-01-26 | 2019-04-26 | 湖南博隽生物医药有限公司 | A kind of biological dressing and preparation method thereof for eliminating scar |
| CN110772572A (en) * | 2019-11-29 | 2020-02-11 | 内蒙古自治区国际蒙医医院(内蒙古自治区蒙医药研究所) | Senden-4 lotion and preparation method thereof |
| CN111297746A (en) * | 2019-12-18 | 2020-06-19 | 佛山科学技术学院 | Shower gel and preparation method thereof |
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Application publication date: 20181218 |