CN105434216A - Pudilan antibacterial and antipruritic shower gel and preparation method thereof - Google Patents

Abstract

The invention provides a pudilan antibacterial and antipruritic shower gel. The pudilan antibacterial and antipruritic shower gel is characterized by comprising the following ingredients in parts by weight: 40-60 parts of water, 0.05-0.2 parts of EDTA.2Na, 0.1-0.5 part of methyl glucose dioleate, 2-8 parts of AESA, 2-8 parts of K12A, 10-30 parts of MES, 1-5 parts of cocamidopropyl diethanolamide (6501), 1-5 parts of disodium Lauryl amphoacetate, 4-10 parts of cocamidopropyl betaine, 1-5 parts of glycerinum, 0.5-1 part of polyquaternium-7, 0.05-0.2 part of a scutellaria extract, 0.5-1 part of a pudilan extract, 0.1-1 part of PEG-7 cocoglycerides (HE), 0.1-1 part of vitamin E, 1-8 parts of water, 1-5 parts of shea butter, 0.1-1 part of a preservative (MPE) and 0.1-1 part of an essence. The pudilan antibacterial and antipruritic shower gel is rich in pudilan active essence ingredient and added with no pigments, can clean skin, has a good transdermal absorption effect, and can effectively solve the problems of skin itches, peeling and the like and protect the skin to be natural and healthy.

Description

Blue anti-bacterial, anti-itching bath gel in a kind of Pu ground and preparation method thereof

Technical field

The invention belongs to medical and health field, be specifically related to blue anti-bacterial, anti-itching bath gel in a kind of Pu ground and preparation method thereof.

Background technology

In daily life, people are after motion, work, and because heating is perspired, pore expansion, is now easily infected by bacterial, and the problems such as skin pruritus occur.Meanwhile, the antibacterial on skin is also easy to enter in body by hands from the channel such as mouth, nose, causes disease.Skin pruritus is common dermatosis, has a lot of people to suffer from us, endangers the physical and mental health of patient, skin pruritus cause reason more, the reason of skin pruritus comprises endogenous cause of ill and exopathogenic factor.

Skin pruritus endogenous cause of ill: internal organs generating function or the organic diseases such as viscera disease, gastrointestinal Liver and kidney, especially the patient of diabetes, uremia, hepatopathy usually has the pruritus of general of whole body; Dyshormonia, also general or circumscribed skin pruritus can be there is in neuropsychiatric obstacle, cerebral arteriosclerosis, tabes dorsalis, neurasthenia, common clinically have neurosis patient to have certain hallucination, and think to have worm in skin and feel and itch, what have forms the custom of scratching.

Than that described above, the infection of the infection of focus, medicine, food anaphylaxis and parasite or fungus all can cause general or limitation skin pruritus.

Skin pruritus exopathogenic factor: the exopathogenic factor of skin pruritus can cause general or regional pruritus, the change of temperature usually causes the pruritus of skin, and bedding is too warm, be heated suddenly or meet the cold outbreak that all may cause pruritus.The stimulation of mechanical friction or chemical factors all can cause the pruritus of local.

Skin pruritus due to dryness majority is cashed as tinea, and the traditional Chinese medical science thinks that heat in blood is main contributor, and heat in blood be formed with many factors, can because of internal injury caused by excess of seven emotions, mechanism of qi harmony is stagnant, strongly fragrant fire-transformation of a specified duration, so that hyperactivity of heart-fire, scorchingly hotly to lie prostrate in nutrient blood, or because of intemperance of taking food, surfeit raw meat starts the thing of wind, taste are become estranged, functional activity of QI being not smooth, strongly fragrant heat-transformation of a specified duration, multiple wind-engaging pyretic toxicity is evil and sick.Because of outer by pathogenic wind toxic cohesion skin table, skin can not make moist, and stays in space between skin and muscles, endocrine disturbance; Or wind heat invades hair key, strongly fragrant blood of a specified duration is dry, Chong and Ren channel disorder, nutrient blood loss, wind syndrome due to blood-deficiency; Or soak outward by damp, occupy wetland for a long time, water slurry floods, and strongly fragrantly loses and supports in the skin skin that causes such as dry and fall ill.Become soaked with sweat if antiperspirant clothing is wet, flood wash rice skin, again by Exposure to Sunlight, heat-damp in summer invades stain hair key, also can cause a disease.

Thus, people often adopt the mode of shower, eliminate pruritus, sterilization.Now, common bath foam and fancy soap do not have antipruritic degerming effect, and go to pharmacy to buy various cream etc. both to have used inconvenience with high costs; And folklore various folk prescription, knack when taking a shower, its effect is difficult to again have stable curative effect, and often cures the symptoms, not the disease, and therefore needs one can antibacterial body wash used in everyday, solves the problem.

Pu ground is blue to be made up of Radix Scutellariae, Radix Isatidis, Herba Taraxaci, Herba Corydalis Bungeanae four taste Chinese medicine, there is good heat-clearing and toxic substances removing, effect of anti-inflammation detumescence, can be used for treatment furuncle and phyma, pharyngitis, tonsillitis, lymphadenitis, parotitis etc., be widely used in internal medicine, urology department, surgery and diseases of eye, ear, nose and throat section.Because compound recipe can be used for reaching by there is collaborative, restriction or guiding etc. between ingredient the object of attenuation synergistic, therefore, be used for the treatment of the advantage that inflammation has its uniqueness.The blue preparation in Pu ground commercially available at present mainly contains the blue Pianomide in Pu ground, the blue oral liquid in Pu ground, Pu ground this several basic dosage form of blue antiphlogistic capsule.Blue for the bath gel of main component does not occur with Pu ground.

Summary of the invention

For solving the problem that skin pruritus class daily nursing articles for use lack, the invention provides a kind of cold-type yellow (clear) bath gel, it is characterized in that, according to weight parts, it consists of the following composition,

According to weight parts, it consists of the following composition,

The preparation method of preferably described bath gel, is characterized in that,

(1) by A heat phase, 65 DEG C are warming up to, insulated and stirred 60min, to dissolving completely;

(2) stop heating, add B phase, stir;

(3) system temperature is down to less than 40 DEG C, adds C phase, stirs;

(4) system temperature 30 DEG C, adds D phase, stirs.

Preferably, the preparation method of described bath gel, is characterized in that,

(1) by EDETATE SODIUM, methyl dioleate is added to the water, be stirred and heated to 65 DEG C, add AESA (AESA), ammonium lauryl sulfate (K12A), monomester succinate disodium salt (MES), cocamide diethanolamine (6501), 65 DEG C of insulated and stirred are to dissolving completely;

(2) stop heating, continue to stir, add lauroyl both sexes sodium acetate, cocamido propyl betaine, glycerol and polyquaternary ammonium salt-7;

(3) system temperature is down to less than 40 DEG C, adds Radix Scutellariae extract, Pu ground blue extract, PEG-7 sodium cocoglyceryl alcohol (HE), vitamin E and water, stirs;

(4) system temperature is down to 30 DEG C, adds shea butter, adds antiseptic (MPE), essence, stirs, standing and defoaming after stirring, the transparent system of bubble-free.

The blue anti-bacterial, anti-itching bath gel in Pu ground of the present invention, is rich in the blue active essential ingredient in Pu ground, does not add pigment.Clean skin, Transdermal absorption is effective, the problems such as effective releasing skin pruritus, scaling, protection skin natural health.

Detailed description of the invention

Embodiment 1

Prescription

Preparation method:

(1) by A heat phase, 65 DEG C are warming up to, insulated and stirred 60min, to dissolving completely;

(2) stop heating, add B phase, stir;

(3) system temperature is down to less than 40 DEG C, adds C phase, stirs;

(4) system temperature 30 DEG C, adds D phase, stirs.

Embodiment 2

Prescription

Preparation method:

(1) by EDETATE SODIUM, methyl dioleate is added to the water, be stirred and heated to 65 DEG C, add AESA (AESA), ammonium lauryl sulfate (K12A), monomester succinate disodium salt (MES), cocamide diethanolamine (6501), 65 DEG C of insulated and stirred are to dissolving completely;

(2) stop heating, continue to stir, add lauroyl both sexes sodium acetate, cocamido propyl betaine, glycerol and polyquaternary ammonium salt-7;

(3) system temperature is down to less than 40 DEG C, adds Radix Scutellariae extract, Pu ground blue extract, PEG-7 sodium cocoglyceryl alcohol (HE), vitamin E and water, stirs;

(4) system temperature is down to 30 DEG C, adds shea butter, adds antiseptic (MPE), essence, stirs, standing and defoaming after stirring, the transparent system of bubble-free.

Embodiment 3

Preparation method:

(1) by EDETATE SODIUM, methyl dioleate is added to the water, be stirred and heated to 65 DEG C, add AESA (AESA), ammonium lauryl sulfate (K12A), monomester succinate disodium salt (MES), cocamide diethanolamine (6501), 65 DEG C of insulated and stirred are to dissolving completely;

(2) stop heating, continue to stir, add lauroyl both sexes sodium acetate, cocamido propyl betaine, glycerol and polyquaternary ammonium salt-7;

(3) system temperature is down to less than 40 DEG C, adds Radix Scutellariae extract, Pu ground blue extract, PEG-7 sodium cocoglyceryl alcohol (HE), vitamin E and water, stirs;

(4) system temperature is down to 30 DEG C, adds shea butter, adds antiseptic (MPE), essence, stirs, standing and defoaming after stirring, the transparent system of bubble-free.

Test example

The clinical data of experimental example one product treatment of the present invention skin pruritus, chronic eczema

Clinical research (one)

One, data and method

1 physical data

With reference to the diagnostic criteria of Ministry of Public Health " new Chinese medicine clinical guidance principle " chronic eczema, skin pruritus.

1.1 treatment front two groups of sexes, ages compared

Treatment group man 66 example, female 54 example, the oldest 70, minimum 18 years old, the mean age (40.41 ± 13.99) year;

The front two groups of courses of disease of 1.2 skin pruritus treatment compare

The treatment group course of disease is the shortest 1 day, the longest 3 years, average course of disease (470.1 ± 1344.3) sky; The matched group course of disease is the shortest 3 days,

The longest 3 years, average course of disease (435.6 ± 868.2) sky, two groups are compared there was no significant difference (P > 0.05).

1.3 cardinal symptom integral contrasts

With reference to the relevant formulation cardinal symptom integration quantitative criteria of " new Chinese medicine treatment eczema obtains guideline of clinical investigations " and " new Chinese medicine treatment pruritus caused by wind pathogen obtains guideline of clinical investigations ".The main clinic symptoms for the treatment of Patients Before And After by asymptomatic, light, in, heavy degree carries out classification balance scoring statistics, the integral contrasts such as the front each cardinal symptom for the treatment of, except the pruritus degree for the treatment of group is heavier than matched group (P < 0.05), the difference (P > 0.05) that compares between all the other cardinal symptom groups that there are no significant, has comparability.

2 medications

Following medicine 15mg is given respectively according to group, one day time 3 times, observe pruritus degree, onset time, skin lesion area, picture of the tongue, pulse condition, related symptoms, Signs, by asymptomatic, light, in, heavy degree scores, before treatment, after treatment the 1st weekend, second weekend each observed and recorded 1 time.

The course for the treatment of: 14 days, two groups of viewing durations all must not merge use other antihistaminic, tranquilizer and other external used medicine.

Curative effect determinate standard: formulate following criterion with reference to " new Chinese medicine clinical guidance principle ": clinical recovery: tcm symptom obviously alleviates or disappears, syndrome integral comparatively treats front decline >=90%; Effective: tcm symptom obviously alleviates, card Hou Jifen comparatively treats front decline >=60%; Effective: tcm symptom alleviates, card Hou Jifen comparatively treats front decline >=30%; Invalid: tcm symptom is not improved or increases the weight of, card Hou Jifen comparatively treats front decline < 30%, and somatic feature score reduces < 30%.

3 health giving quality observations

3.1 bacterial infection skin pruritus, namely to the total effects of bacterial infection skin pruritus

Group	N	Cure rate (%)	Obvious effective rate (%)	Effective percentage (%)
					Embodiment 1	20	30	40	80
Embodiment 2	20	20	50	65

Embodiment 3

20

40

60

95

The skin pruritus that 3.2 pairs of fungal infection cause, namely to the total effects of fungal infectious skin pruritus

Group	N	Cure rate (%)	Obvious effective rate (%)	Effective percentage (%)
					Embodiment 1	20	15	45	70
Embodiment 2	20	25	60	60
					Embodiment 3	20	40	70	96

The curative effect of the present composition is obvious, has the effect of Synergistic between the compositions of the application.To the skin pruritus that different reason causes, there is significant therapeutic effect.

The blue anti-bacterial, anti-itching bath gel in Pu ground of the present invention, is rich in the blue active essential ingredient in Pu ground, does not add pigment.Clean skin, effective to Transdermal absorption, the problems such as effective releasing skin pruritus, scaling, protection skin natural health.

Above-mentioned detailed description is illustrating for one of them possible embodiments of the present invention, and this embodiment is also not used to limit the scope of the claims of the present invention, and the equivalence that all the present invention of disengaging do is implemented or changed, and all should be contained in the scope of technical solution of the present invention.

Claims (4)

1. the blue anti-bacterial, anti-itching bath gel in Pu ground, it is characterized in that, according to weight parts, it consists of the following composition,

2. bath gel according to claim 1, is characterized in that, according to weight parts, it consists of the following composition,

3. the preparation method of bath gel according to claim 1 and 2, is characterized in that,

(1) by A heat phase, 65 DEG C are warming up to, insulated and stirred 60min, to dissolving completely;

(2) stop heating, add B phase, stir;

(3) system temperature is down to less than 40 DEG C, adds C phase, stirs;

(4) system temperature 30 DEG C, adds D phase, stirs.

4. the preparation method of bath gel according to claim 1 and 2, is characterized in that,

(1) by EDETATE SODIUM, methyl dioleate is added to the water, be stirred and heated to 65 DEG C, add AESA (AESA), ammonium lauryl sulfate (K12A), monomester succinate disodium salt (MES), cocamide diethanolamine (6501), 65 DEG C of insulated and stirred are to dissolving completely;

(2) stop heating, continue to stir, add lauroyl both sexes sodium acetate, cocamido propyl betaine, glycerol and polyquaternary ammonium salt-7;

(3) system temperature is down to less than 40 DEG C, adds Radix Scutellariae extract, Pu ground blue extract, PEG-7 sodium cocoglyceryl alcohol (HE), vitamin E and water, stirs;

(4) system temperature is down to 30 DEG C, adds shea butter, adds antiseptic (MPE), essence, stirs, standing and defoaming after stirring, the transparent system of bubble-free.