CN103127261B - A kind of Chinese medicine composition for the treatment of prurigo - Google Patents

A kind of Chinese medicine composition for the treatment of prurigo Download PDF

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CN103127261B
CN103127261B CN201110403662.XA CN201110403662A CN103127261B CN 103127261 B CN103127261 B CN 103127261B CN 201110403662 A CN201110403662 A CN 201110403662A CN 103127261 B CN103127261 B CN 103127261B
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prurigo
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CN103127261A (en
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王莲芬
董娜
马翔
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Qidong Jian Jian agricultural and sideline products professional cooperatives
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王莲芬
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Abstract

The invention discloses a kind of Chinese medicine composition for the treatment of prurigo, belong to technical field of traditional Chinese medicine preparation.Chinese patent medicine of the present invention is by Rhizoma Coptidis 4-20 part, Fructus Atriplicis Sibiricae 8-30 part, Pumex 2-6 part, Pheretima 1-4 part, Radix Sophorae Flavescentis 1-5, Radix Et Rhizoma Rhei 2-15 part, and Cortex Pseudolaricis 2-15 part, Borneolum Syntheticum 2-20 part, conveniently pharmaceutical methods makes various peroral dosage form.Chinese patent medicine of the present invention has and improves body constitution, makes rehabilitation normal.

Description

A kind of Chinese medicine composition for the treatment of prurigo
Technical field
The present invention relates to technical field of traditional Chinese medicine pharmacy, particularly relate to a kind of Chinese medicine composition for the treatment of prurigo.
Background technology
Prurigo is acute or the sick general name of chronic inflammatory skin, is apt to occur in extremity and stretches side, belong to pruritic dermatosis.Mostly skin lesion is isolated pimple or tuberosity, stays with pigmentation more afterwards, and there is violent pruritus at skin lesion place, local.The course of disease is chronic, and several months or several years do not heal sometimes.Different according to clinical manifestation, prurigo divide be called prurigo infantilis, ordinary itch examine, prurigo nodularis, prurigo gestationis and summer prurigo etc.
Prurigo, it is generally acknowledged relevant with allergy, and some patients have family's allergies, and thus prurigo infantilis is relevant with atoipc dermatitis.What have first has papular urticaria, then prurigo is relevant with insect bite.Because prurigo gestationis divides puerperium spontaneous recovery, therefore someone thinks relevant with endocrine change.Also the scholar had thinks, extraneous sensitization contactant, and daylight, caused by the allergy of food and medicine.In addition with digestive system function obstacle, the infection of focus, the malignant tumor in body, psychoneural factor etc. all may be relevant with the generation of primary disease.
The pathological change of prurigo is non specific chronic inflammation, and epidermis has hyperkeratosis and parakeratosis, and prickle cell layer is plump, and intraepidermal edema, epidermis shallow-layer vesicle can occur.Intradermal Mild edema, has lymphocytic infiltration around blood vessel.Prurigo nodularis pathology epidermis has obvious hyperkeratosis and acanthosis, in papillomatous hyperplasia, and high dermis histiocyte, lymphocytic infiltration.
Chinese medicine is to prurigo vulgaris, and wind treatment by Chinese herbs is gone in the available heat clearing away of prurigo etc. in summer, and adopt the anti-heat clearing away soup of chaste tree, it is controlled by removing heat from blood fresh breeze soup.Clearing away heat and expelling wind activating blood circulation to dissipate blood stasis is answered to be the rule for the treatment of to prurigo nodularis.Adopt prurigo side, Yongan itching-stopping prescription, have and insufficiency of the spleen adopt plus-minus stomach Siberian cocklebur soup etc.The external of external used medicine phenol Calamine Lotion, also can put on the skin with outside the ointment of corticosteroid or cream.
Summary of the invention
The present invention, for better, effectively to treat prurigo, provides that a kind of safety is high, good effect, the medicine that meets drug matching principle is used for the treatment of prurigo.
The present invention adopts following technical scheme: a kind of Chinese medicine composition for the treatment of prurigo, its special character is made up of the medicine of following weight proportioning: Rhizoma Coptidis 4-20 part, Fructus Atriplicis Sibiricae 8-30 part, Pumex 2-6 part, Pheretima 1-4 part, Radix Sophorae Flavescentis 1-5 part, Radix Et Rhizoma Rhei 2-15 part, Cortex Pseudolaricis 2-15 part, Borneolum Syntheticum 2-20 part.
The preferred version of the medicine of above-mentioned weight proportion is:
Be made up of the medicine of following weight proportioning; Rhizoma Coptidis 9-15 part, Fructus Atriplicis Sibiricae 13-25 part, Pumex 3-5 part, Pheretima 1-3 part, Radix Sophorae Flavescentis 1-5 part, Radix Et Rhizoma Rhei 7-10 part, Cortex Pseudolaricis 7-10 part, Borneolum Syntheticum 7-10 part.
The preferred plan of the medicine of above-mentioned weight proportion is:
Be made up of the medicine of following weight proportioning: Rhizoma Coptidis 12 parts, Fructus Atriplicis Sibiricae 18 parts, Pumex 4 parts, Pheretima 2 parts, Radix Sophorae Flavescentis 3 parts, Radix Et Rhizoma Rhei 9 parts, Cortex Pseudolaricis 9 parts, Borneolum Syntheticum 9 parts.
Chinese patent medicine described above makes the different oral medicine dosage form of pill, sublimed preparation, powder, tablet, unguentum, decoction and capsule dress powder according to Chinese medicine conventional formulation techniques.
The principles of formulating prescriptions of Chinese patent medicine of the present invention are: improve body constitution, make rehabilitation normal.Based on spleen invigorating, removing dampness, invigorate blood circulation, rush down clearly.The present invention has that compatibility of drugs is proper, reasonable recipe, and described in it, effect of each herbal medicine is:
Rhizoma Coptidis: the function with dampness heat clearing away, eliminating fire and detoxication.
Fructus Atriplicis Sibiricae: have that loose wind is soothing the liver, the effect of circulation of qi promoting removing blood stasis, dispelling pathogenic wind for improving eyesight, can control the dermatosiss such as skin infection pruritus, vitiligo and the children's's head sore that wind heat causes; And control the oculopathy of the many tear of conjunctival congestion, the raw nebula film of order, and nebula film can be made to eliminate, clear depending on thing.
Pumex: lung heat clearing fire; Change old expectorant; Relieving stranguria by diuresis; Hard masses softening and resolving
Pheretima: there is dredge the meridian passage, blood circulation promoting and blood stasis dispelling, the effect of prophylactic treatment cardiovascular and cerebrovascular disease.
Radix Sophorae Flavescentis: heat clearing and damp drying, parasite killing, diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment trichomonal vaginitis.
Radix Et Rhizoma Rhei: attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; Removing toxic substances
Cortex Pseudolaricis: parasite killing, antipruritic.For scabies pruritus.
Borneolum Syntheticum: logical all keys, loose stagnated fire, removing nebula improving eyesight, reducing swelling and alleviating pain.Control apoplexy locked mouth, calentura coma, infantile convulsion expectorant fan, deafness with qi stagnation, sore throat, aphtha, otitis media, carbuncle, hemorrhoid, order is nebula film also, enterobiasis.
The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", whole composition comes from China's " pharmacopeia " the 5th edition medicine recorded, all medicine phases and there is temperature compensation liver spleen altogether, loose wind dehumidifying, QI and blood regulating, dredge the meridian passage, blood circulation promoting and blood stasis dispelling, righting are got rid of evils, immunity moderation function, improves skin microcirculation, reaches object, the determined curative effect for the treatment of and prevention prurigo, have no side effect, various Chinese medicine preparation taking convenience.
Chinese patent medicine result in clinical application of the present invention shows, tool has the following advantages:
1, the Chinese medicine each component that the present invention selects meets the regulation of the Drug Administration Law of People's Republic of China, utilizes comprehensive function treatment and the prevention eczema of each taste Chinese medicine, harmless to human non-toxic.Show that underproof animal has no any toxic reaction through the acute toxicity test of white mice and rat and accumulation toxicity test, compare zero difference through anatomic observation hemogram, liver function, each organs and tissues morphology finding with matched group, prove that its safety of medicine is reliable.
2, Chinese patent medicine preparation of the present invention not only effectively can treat eczema, and to the preventive effect of eczema also clearly, particularly by mutually working in coordination with between medicine, strengthen medicine and treat characteristic separately, by dredge the meridian passage and immunity moderation function, improve the healthy energy of patient body inherence and physically and mentally healthy and life quality, reach healing rehabilitation efficacy preferably.
The therapeutic effect of patent medicine of the present invention to treatment prurigo is further illustrated below by clinical practice example.
One, clinical diagnosis:
Prurigo diagnosis basis: erythra mostly is erythema, pimple, nodular lesion, symmetrical arc is vertical to be occurred, and sends out extremity well and stretches side, especially obvious with upper limb.Erythra leaves pigmentation patch more afterwards, and accompany violent pruritus, the course of disease is chronic, diagnosis of being not difficult.
Two, the selection of case
Prurigo is a kind of common disease, and easily recurs, and case selection was chosen according to different sexes, age.Age 20-50 year in, the selection of case goes to a doctor patient for case totally 65 examples with door rash, diagnose: divide by sex according to " clinical criteria ": male 40 example, and women 25 is routine; Age-based point: 20-30 year 30 examples, 30-40 year 20 routine .40-50 year 15 examples.
Model case 3 example below chosen wherein describes.
Case 1
Patient Mr. Zhou, suffer from prurigo for many years, he does vocational work in unit, due to job demand, travelling widely is frequent thing, makes his diet, lives do not have what rule, and the weather of various places, temperature, humidity difference, result in his disease recurrent exerbation.After diagnosis and treatment, opened the prescription of a course for the treatment of to Mr. Zhou, after taking medicine 15 days, patient feels that whole body itches alleviation of pain gently, and after 30 days, skin lesion takes a turn for the better, and incrustation gradually dissolving is softened, come off.In front and back after the treatment by Chinese herbs of five courses for the treatment of of thing, patient has grown fresh skin, recurrence that so far there are no.
Case 2
Patient He Nvshi, suffer from more than ten years of prurigo, with crossing a lot of external application liquid medicine, ointment and oral Chinese medicine and western medicine much, but with regard to recurrent exerbation after drug withdrawal, disease does not develop into sepage, drying, incrustation, coarse, plump and breach more gradually due to long-term, and attend by unbearable itching, particularly at night the having difficulty in going to sleep of pruritus.In unit, colleague is afraid of that " infection " is unwilling and her dealing; At home, be afraid of that " infection " is to household, she isolates herself.Taking special prescription after 10 days, Mrs He feels that whole body itches alleviation of pain gently, and after one month, skin lesion starts to take a turn for the better, and incrustation gradually dissolving is softened, come off.Before and after after the Chinese medicine conditioning of four courses for the treatment of, skin lesion disappears substantially, after again after two courses for the treatment of of after treatment, Mrs He has healthy and beautiful skin and happy mood finally again.
Case 3
Patient business, man, 50 years old.Whole body pruritus, grabs to scratch and increases the weight of, and scratches place's blood oozing from the body openings or subcuta neous tissue, and with broken with receipts, the red red bright hands of whole skin, face plays the hard furuncle of countless Semen Glycines sizes, not ulceration.Readme once his institute take medicine a couple of days and quiet note calcium gluconate injection many days invalid, introduce through other people the traditional Chinese medical science of seeking medical advice.After using Chinese medicine of the present invention, the state of an illness obtains medical treatment, and takes a turn for the better.
Three, curative effect determinate standard
Clinical cure, skin lesion all disappears, and pruritus disappears: effective, skin is with the > 50% that disappears, and pruritus obviously alleviates; Effectively, skin
Damage partial remission, pruritus alleviates; Invalid, skin lesion has no and disappears.
Four, clinical application method and therapeutic outcome
1, clinical application method
The administrated method of eczema mainly contains for oral administration and external.For oral administration mainly by the treatment process of existing Chinese medicine, drug treating become oral liquid, pill, capsule to fill powder or tablet etc., external is added water by medicine, is heated to boiling and directly utilizes steam to fumigate disease sites.
2, therapeutic outcome
Through clinical diagnosis control eczema patients amount to 65 example, male 40 example, women 25 example, the age be 20-50 year.18 examples that are almost recovered in 65 routine patients account for 27.7%, and effective 29 examples account for 44.6%, and effective 15 examples account for 23.1%, and invalid 3 examples account for 4.6%, and total effective rate reaches 95.4%.After treatment, patient skin recovers bright and clean.
Detailed description of the invention
Embodiment 1
Prurigo is treated with decoction.Rhizoma Coptidis 4 parts, Fructus Atriplicis Sibiricae 8 parts, Pumex 2 parts, Pheretima 1 part, Radix Sophorae Flavescentis 1 part, Radix Et Rhizoma Rhei 2 parts, Cortex Pseudolaricis 2 parts, Borneolum Syntheticum 2 parts.After adopting slow fire to decoct in above-mentioned Chinese medicine, collect medicinal liquid after taking, effectively can treat prurigo disease, reach ideal effect.
Embodiment 2
By pill or sublimed preparation treatment prurigo.Rhizoma Coptidis 20 parts, Fructus Atriplicis Sibiricae 30 parts, Pumex 6 parts, Pheretima 4 parts, Radix Sophorae Flavescentis 5 parts, Radix Et Rhizoma Rhei 15 parts, Cortex Pseudolaricis 15 parts, Borneolum Syntheticum 20 parts.Said medicine group is confusingly dried, ground, adds Mel, be prepared into pill, or adopt the formulation method of existing Chinese medicine to make sublimed preparation, every 10 days is a course for the treatment of, serve on 9 courses for the treatment of, namely heals.
Embodiment 3
Prurigo is treated with powder or tablet medicine.Rhizoma Coptidis 9 parts, Fructus Atriplicis Sibiricae 13 parts, Pumex 3 parts, Pheretima 1 part, Radix Sophorae Flavescentis 1 part, Radix Et Rhizoma Rhei 7 parts, Cortex Pseudolaricis 7 parts, Borneolum Syntheticum 7 parts.Adopt the formulation method of existing Chinese medicine to make powder or tablet in as above Chinese medicine, every 10 days is a course for the treatment of, serve on 9 courses for the treatment of, namely heals.
Embodiment 4
By unguentum clothes treatment prurigo.Rhizoma Coptidis 15 parts, Fructus Atriplicis Sibiricae 25 parts, Pumex 5 parts, Pheretima 3 parts, Radix Sophorae Flavescentis 5 parts, Radix Et Rhizoma Rhei 10 parts, Cortex Pseudolaricis 10 parts, Borneolum Syntheticum 10 parts.As above Chinese medicine is produced into unguentum according to the conventional manufacturing techniques of tablet oral medicine, and every 10 days is a course for the treatment of, serve on 9 courses for the treatment of, namely heals.
Embodiment 5
Prurigo is treated with fumigation and steaming method.Rhizoma Coptidis 12 parts, Fructus Atriplicis Sibiricae 18 parts, Pumex 4 parts, Pheretima 2 parts, Radix Sophorae Flavescentis 3 parts, Radix Et Rhizoma Rhei 9 parts, Cortex Pseudolaricis 9 parts, Borneolum Syntheticum 9 parts.By said medicine component mix homogeneously, add water, be heated to boiling, disease sites is put above handtailor container and directly fumigate, coordinate endo-medicine treatment.After using, effectively can treat eczema, reach ideal effect.Within every 10 days, be a course for the treatment of (once a day), 9 courses for the treatment of of continuous fumigation, namely heal.

Claims (1)

1. treat a Chinese medicine composition for prurigo, it is characterized in that being made up of the medicine of following weight proportioning: Rhizoma Coptidis 12 parts, Fructus Atriplicis Sibiricae 18 parts, Pumex 4 parts, Pheretima 2 parts, Radix Sophorae Flavescentis 3 parts, Radix Et Rhizoma Rhei 9 parts, Cortex Pseudolaricis 9 parts, Borneolum Syntheticum 9 parts.
CN201110403662.XA 2011-11-29 2011-11-29 A kind of Chinese medicine composition for the treatment of prurigo Active CN103127261B (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105521326A (en) * 2015-09-17 2016-04-27 张名静 Traditional Chinese medicine for treating hebra prurigo

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Publication number Priority date Publication date Assignee Title
US6171593B1 (en) * 1994-11-10 2001-01-09 Johnny L. Williams Method of treating skin disorders using an extract of mullein
CN1628809A (en) * 2004-10-21 2005-06-22 牛山林 Chinese traditional medicine for treating pruritus
CN1679754A (en) * 2005-01-20 2005-10-12 李木林 Strong-effect external-applied preparation for treating multiple skin diseases
CN101049453A (en) * 2007-05-16 2007-10-10 北京艺信堂医药研究所 Preparation of Chinese traditional medicine for treating nodule pruritus
US7678393B1 (en) * 2006-04-23 2010-03-16 DB Laboratories LLC Mixture composition and method useful for topical and internal application

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6171593B1 (en) * 1994-11-10 2001-01-09 Johnny L. Williams Method of treating skin disorders using an extract of mullein
CN1628809A (en) * 2004-10-21 2005-06-22 牛山林 Chinese traditional medicine for treating pruritus
CN1679754A (en) * 2005-01-20 2005-10-12 李木林 Strong-effect external-applied preparation for treating multiple skin diseases
US7678393B1 (en) * 2006-04-23 2010-03-16 DB Laboratories LLC Mixture composition and method useful for topical and internal application
CN101049453A (en) * 2007-05-16 2007-10-10 北京艺信堂医药研究所 Preparation of Chinese traditional medicine for treating nodule pruritus

Non-Patent Citations (1)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105521326A (en) * 2015-09-17 2016-04-27 张名静 Traditional Chinese medicine for treating hebra prurigo

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Effective date of registration: 20170511

Address after: The 20 group of Qidong Yin Yang Zhen Hou Zi Cun, Jiangsu city of Nantong province 226200

Patentee after: Qidong Jian Jian agricultural and sideline products professional cooperatives

Address before: 264000 Yantai psoriasis research institute, 11 Wenhua Road, Zhifu District, Shandong, Yantai

Patentee before: Wang Lianfen