CN107308085A - A kind of whitening highlights composition and preparation method thereof - Google Patents
A kind of whitening highlights composition and preparation method thereof Download PDFInfo
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- CN107308085A CN107308085A CN201710637516.0A CN201710637516A CN107308085A CN 107308085 A CN107308085 A CN 107308085A CN 201710637516 A CN201710637516 A CN 201710637516A CN 107308085 A CN107308085 A CN 107308085A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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Abstract
The present invention relates to plant extracts field, more particularly to a kind of whitening highlights composition and preparation method thereof.The whitening highlights composition, and its raw material at least includes：20~60 parts of spikemoss extract, 10~30 parts of tomato extract, 3~10 parts of ambrette seed extract, 5~20 parts of acetyl chitosamine, 3~18 parts of hyaluronic acid, 1~10 part of hyaluronic acid of hydrolysis, 1~8 part of dipotassium glycyrrhizinate, 10~30 parts of deionized water.
Description
Technical field
The present invention relates to plant extracts field, more particularly to a kind of whitening highlights composition and preparation method thereof.
Background technology
With the fast development of China's economy, people increase further for the concern of " U.S. ", and cosmetic industry is on this opportunity
Flourish, and " whitening " is then the eternal topic of cosmetic industry.Whitening raw material on the market, whitening product species are numerous
It is many, give cosmetics engineer, producer and user and greatly select space, but cause lack of standardizationization of Cosmetic Market simultaneously simultaneously
Increase the supervision difficulty of relevant departments.So, the exploitation use for whitening additive is necessary to grind by the experiment of science
Study carefully and quality testing.Whitening raw material on the market is broadly divided into chemistry, biological and natural plant kind now.Chemical classes whitening agent is imitated
Significantly, typically directly to destroy melanocyte as main action pathway (such as quinhydrones), but such whitening agent has necessarily fruit mostly
Cytotoxicity or have to human body certain damaging.Biological species whitening agent due to originate safer, the advantages of effect is objective, into
One of main line for research in recent years, but due to the limitation of technology development, most production cycle is longer, low yield, and cost is high.And day
Right plant (Chinese herbal medicine) source is natural, to having obvious security compared with chemical classes whitening agent, to compared with biological species whitening agent
Again be more easy to get, low cost.Meanwhile, the species of natural plants is various, and wide materials space is provided for the research and development of whitening raw material；
And Traditional Chinese Medicine medication can provide new Research Thinking based on herbal medicine for whitening research.
Thus, it is highly desirable to provide and integrates whitening, moisturizing, the multi-functional whitening of anti-inflammation and sterilization and highlight combination
Thing.
The content of the invention
In order to solve the above-mentioned technical problem, the first aspect of the invention provides a kind of whitening and highlights composition, described U.S.
Composition is highlighted in vain, in parts by weight, its raw material at least includes：20~60 parts of spikemoss extract, 10~30 parts of tomato extract,
3~10 parts of ambrette seed extract, 5~20 parts of acetyl chitosamine, 3~18 parts of hyaluronic acid, hydrolysis 1~10 part of hyaluronic acid, sweet
1~8 part of oxalic acid dipotassium, 10~30 parts of deionized water.
As a kind of preferred technical scheme of the present invention, the whitening highlights composition, and in parts by weight, its raw material is at least
Including：40~50 parts of spikemoss extract, 20~25 parts of tomato extract, 5~8 parts of ambrette seed extract, acetyl chitosamine 15~
20 parts, 10~15 parts of hyaluronic acid, hydrolysis 5~8 parts of hyaluronic acid, 5~7 parts of dipotassium glycyrrhizinate, 20~30 parts of deionized water.
As a kind of preferred technical scheme of the present invention, the whitening highlights composition, and in parts by weight, its raw material is at least
Including：45 parts of spikemoss extract, 25 parts of tomato extract, 6 parts of ambrette seed extract, 18 parts of acetyl chitosamine, hyaluronic acid 13
Part, 6 parts of hyaluronic acid of hydrolysis, 6 parts of dipotassium glycyrrhizinate, 30 parts of deionized water.
As a kind of preferred technical scheme of the present invention, the whitening highlights composition, and in parts by weight, its raw material is also wrapped
Include：
Pomegranate, Selaginella tamariscina, 8 parts of 20 parts of extract microcapsules, Megranate Seed P.E, the hyperici,herba extract 5 of radix glycyrrhizae mixture
Part, 10 parts of Fructus Luffae extract, 10 parts of alpha-arbutin, 12 parts of adlay extract, 8 parts of Notogineng Extract, gold engrave leaf of plum extract 15
Part, 6 parts of camomile extract, 4 parts of milk thistle extract, 10 parts of Gotu Kola P.E, 7 parts of elderberry extract, cucumber are extracted
5 parts of thing, 8 parts of gadol extract, 4 parts of wolfberry fruit extract, 3 parts of Seabuckthorn Oil, 4 parts of Herba Lysimachiae foenumgraeci extract.
It is pomegranate, Selaginella tamariscina, sweet in the pomegranate, Selaginella tamariscina, radix glycyrrhizae mixture as a kind of preferred technical scheme of the present invention
Weight ratio between grass is：100：(1~20)：(1~5).
As a kind of preferred technical scheme of the present invention, the pomegranate, Selaginella tamariscina, the extract microcapsules of radix glycyrrhizae mixture
Preparation method is as follows：
Weigh after pomegranate, Selaginella tamariscina, radix glycyrrhizae mixing, crushed, obtain 50g raw materials, it is 50% to add 300g mass fractions
Ethanol solution, while adding the active liquid of 0.01g fullerenes into ethanol solution, at 40 DEG C, ultrasonic 60min obtains first and carried
Take thing；
Weigh 10g cyst materials to be dissolved in 50g distilled water, treat cyst material all dissolvings, and add 6g at room temperature
First extract, stirs, ultrasonic 30min, is well mixed it, in 175 DEG C of inlet temperature, feed rate 3mL/min, spray
It is spray-dried under the conditions of 2 times/min of mouth diameter 0.7mm and nozzle cleaning, obtains pomegranate, Selaginella tamariscina, radix glycyrrhizae mixture and carry
Take thing microcapsules；
The cyst material is：Chitosan and ultrabranching polyamide compound, the mixture of Arabic gum；Chitosan is with surpassing
Weight ratio between branched polyamide compound, Arabic gum is 1：1.
As a kind of preferred technical scheme of the present invention, the whitening, which highlights composition, also includes the fowler of 0.1 parts by weight
Alkene activity liquid.
As a kind of preferred technical scheme of the present invention, the whitening highlights the preparation that composition is following form：Creme,
Granule, ointment, foaming agent, lotion, emplastrum, tablet, emulsion.
The second aspect of the invention provides the preparation method that a kind of whitening highlights composition, at least comprises the following steps：
(1) by deionized water, spikemoss extract, tomato extract, ambrette seed extract, hydrolysis hyaluronic acid, glycyrrhizic acid
Dipotassium is mixed, after being stirred at 30 DEG C, is added hyaluronic acid, acetyl chitosamine keeping temperature and is continued to stir after 30min, obtains
To the first product；
(2) Megranate Seed P.E, hyperici,herba extract, Fructus Luffae extract, alpha-arbutin, adlay extract, pseudo-ginseng are carried
Thing, gold is taken to engrave leaf of plum extract, camomile extract, milk thistle extract, Gotu Kola P.E, elderberry extract, cucumber
Extract, gadol extract, wolfberry fruit extract, Seabuckthorn Oil, Herba Lysimachiae foenumgraeci extract mix 60min at room temperature, then add
Enter the active liquid of pomegranate, Selaginella tamariscina, the extract microcapsules of radix glycyrrhizae mixture, fullerene and stir 30min at 50 DEG C, be cooled to room temperature
Obtain the second product；
(3) the second product is all instilled in the first product, deposits 24h at -5 DEG C, obtain whitening and highlight composition.
The third aspect of the invention highlights application of the composition in skin conditioning agent field there is provided whitening.
Embodiment
Unless otherwise defined, all technologies used herein and scientific terminology have and the common skill of art of the present invention
The identical implication that art personnel are generally understood that.When there is contradiction, the definition in this specification is defined.
" quality, concentration, temperature, time or other values or parameter are preferred with scope, preferred scope or a series of upper limits
During the Range Representation that value and lower preferable values are limited, this, which is appreciated that, specifically discloses by any range limit or preferred value
All scopes that any pairing with any range lower limit or preferred value is formed, regardless of whether whether the scope separately discloses.
For example, 1-50 scope is understood to include selected from 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,
19、20、21、22、23、24、25、26、27、28、29、30、31、32、33、34、35、36、37、38、39、40、41、42、43、
44th, 45,46,47,48,49 or 50 any numeral, number combinatorics on words or subrange and all between above-mentioned integer
Fractional value, for example, 1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8 and 1.9.It is specific to consider from scope on subrange
Interior any end points starts " the nested subrange " of extension.For example, exemplary range 1-50 nested subrange can include
1-10,1-20,1-30 and 1-40 on one direction, or 50-40,50-30,50-20 and 50-10 on other direction.”
In order to solve the above-mentioned technical problem, the first aspect of the invention provides a kind of whitening and highlights composition, described U.S.
Composition is highlighted in vain, in parts by weight, its raw material at least includes：20~60 parts of spikemoss extract, 10~30 parts of tomato extract,
3~10 parts of ambrette seed extract, 5~20 parts of acetyl chitosamine, 3~18 parts of hyaluronic acid, hydrolysis 1~10 part of hyaluronic acid, sweet
1~8 part of oxalic acid dipotassium, 10~30 parts of deionized water.
As a kind of preferred technical scheme of the present invention, the whitening highlights composition, and in parts by weight, its raw material is at least
Including：40~50 parts of spikemoss extract, 20~25 parts of tomato extract, 5~8 parts of ambrette seed extract, acetyl chitosamine 15~
20 parts, 10~15 parts of hyaluronic acid, hydrolysis 5~8 parts of hyaluronic acid, 5~7 parts of dipotassium glycyrrhizinate, 20~30 parts of deionized water.
As a kind of preferred technical scheme of the present invention, the whitening highlights composition, and in parts by weight, its raw material is at least
Including：45 parts of spikemoss extract, 25 parts of tomato extract, 6 parts of ambrette seed extract, 18 parts of acetyl chitosamine, hyaluronic acid 13
Part, 6 parts of hyaluronic acid of hydrolysis, 6 parts of dipotassium glycyrrhizinate, 30 parts of deionized water.
Spikemoss extract
In the present invention, the spikemoss extract is purchased from the Hao Bo bio tech ltd of Shanghai hundred.
Tomato extract
In the present invention, the tomato extract is purchased from the Hao Bo bio tech ltd of Shanghai hundred.
Ambrette seed extract
In the present invention, the ambrette seed extract is ambrette extract, is purchased from the green limited public affairs of biotechnology of Xi'an gold
Department.
Acetyl chitosamine
In the present invention, the acetyl chitosamine is purchased from Bloomage Freda Biopharm Co., Ltd..
Hyaluronic acid
In the present invention, the hyaluronic acid is purchased from Bloomage Freda Biopharm Co., Ltd..
Hydrolyze hyaluronic acid
In the present invention, the hydrolysis hyaluronic acid is purchased from Bloomage Freda Biopharm Co., Ltd..
Dipotassium glycyrrhizinate
In the present invention, the dipotassium glycyrrhizinate is purchased from Ke Sifa international trades (Shanghai) Co., Ltd. Beijing Company.
As a kind of preferred technical scheme of the present invention, the whitening highlights composition, and in parts by weight, its raw material is also wrapped
Include：
Pomegranate, Selaginella tamariscina, 8 parts of 20 parts of extract microcapsules, Megranate Seed P.E, the hyperici,herba extract 5 of radix glycyrrhizae mixture
Part, 10 parts of Fructus Luffae extract, 10 parts of alpha-arbutin, 12 parts of adlay extract, 8 parts of Notogineng Extract, gold engrave leaf of plum extract 15
Part, 6 parts of camomile extract, 4 parts of milk thistle extract, 10 parts of Gotu Kola P.E, 7 parts of elderberry extract, cucumber are extracted
5 parts of thing, 8 parts of gadol extract, 4 parts of wolfberry fruit extract, 3 parts of Seabuckthorn Oil, 4 parts of Herba Lysimachiae foenumgraeci extract.
Pomegranate, Selaginella tamariscina, the extract microcapsules of radix glycyrrhizae mixture
Term " pomegranate, Selaginella tamariscina, the extract microcapsules of radix glycyrrhizae mixture " refers to pomegranate, Selaginella tamariscina, radix glycyrrhizae mixture
Extract is capsule-core, using chitosan and ultrabranching polyamide compound, Arabic gum mixture as wall material.The pomegranate is selected from
Granatum.
Term " pomegranate, Selaginella tamariscina, the extract microcapsules of radix glycyrrhizae mixture " refers to pomegranate, Selaginella tamariscina, radix glycyrrhizae mixing laggard
Row extracts obtained pomegranate, Selaginella tamariscina, the extract of radix glycyrrhizae mixture.
Term " chitosan and ultrabranching polyamide compound, the mixture of Arabic gum " refers to chitosan first and end ammonia
Base ultrabranching polyamide is first combined, and obtains chitosan and amine-terminated hyperbrancedization polyamide compound, then, and chitosan is with surpassing
Branched polyamide compound carries out being mixed to get wall material with Arabic gum.
In a preferred embodiment, the pomegranate, Selaginella tamariscina, the preparation side of the extract microcapsules of radix glycyrrhizae mixture
Method is as follows：
Weigh after pomegranate, Selaginella tamariscina, radix glycyrrhizae mixing, crushed, obtain 50g raw materials, it is 50% to add 300g mass fractions
Ethanol solution, while adding the active liquid of 0.01g fullerenes into ethanol solution, at 40 DEG C, ultrasonic 60min obtains first and carried
Take thing；
Weigh 10g cyst materials to be dissolved in 50g distilled water, treat cyst material all dissolvings, and add 6g at room temperature
First extract, stirs, ultrasonic 30min, is well mixed it, in 175 DEG C of inlet temperature, feed rate 3mL/min, spray
It is spray-dried under the conditions of 2 times/min of mouth diameter 0.7mm and nozzle cleaning, obtains pomegranate, Selaginella tamariscina, radix glycyrrhizae mixture and carry
Take thing microcapsules；
The cyst material is：Chitosan and ultrabranching polyamide compound, the mixture of Arabic gum；Chitosan is with surpassing
Weight ratio between branched polyamide compound, Arabic gum is 1：1.
The ultrabranching polyamide is amine-terminated hyperbrancedization polyamide, and product grade is：HyPer HPN202, are purchased from Wuhan
Hyperbranched resin Co., Ltd.
The chitosan is water soluble chitosan, is purchased from Jinan Haidebei Marine Organism Engineering Co., Ltd..
In a preferred embodiment, the preparation method of the chitosan and ultrabranching polyamide compound, at least
Comprise the following steps：
5g dodecanedioic acid is dissolved in 20mL dimethyl sulfoxide (DMSO)s and obtains dodecanedioic acid solution；15g shell is gathered
Sugar is dissolved in 50mL dimethyl sulfoxide (DMSO)s and obtains chitosan solution；15g ultrabranching polyamide is dissolved in 50mL dimethyl sub-
Ultrabranching polyamide solution is obtained in sulfone；Then dodecanedioic acid solution is added in reactor, stirred, keeping temperature 50
DEG C, cool after then adding chitosan solution, reaction 3h, you can obtain dodecanedioic acid modification of chitosan；Then to 12
Ultrabranching polyamide solution is added in docosandioic acid modification of chitosan, at 60 DEG C, continues to react cooling after 2h, washs, dries, i.e.,
It can obtain chitosan and ultrabranching polyamide compound.
Megranate Seed P.E
In the present invention, the Megranate Seed P.E is purchased from Lanzhou water Lai Si bio tech ltd.
Hyperici,herba extract
The commercially available acquisition of hyperici,herba extract in the present invention, can also make by oneself and obtain.
In a preferred embodiment, the preparation method of described hyperici,herba extract is：
Hyperici,herba is cleaned, shredded, the ethanol that mass fraction is 80% is added, soaks 2h, then Microwave Extraction 2h, will be molten
Agent, which is evaporated, obtains hyperici,herba extract.In the present invention, the hyperici,herba extract is purchased from the auspicious special limited public affairs of biotechnology of Xi'an Australia
Department.
Fructus Luffae extract
In the present invention, the Fructus Luffae extract is purchased from the big magnificent great achievement medication chemistry Co., Ltd in Wuhan.
Alpha-arbutin
In the present invention, the alpha-arbutin is purchased from Suzhou great virtue carbon nanosecond science and technology Co., Ltd.Meanwhile, also with moisturizing,
More create, sterilize and cooperate with the effect such as anti-inflammatory.
Adlay extract
In the present inventionAdlay extractIt is commercially available to obtain, it can also make by oneself and obtain.
In a preferred embodiment, the preparation method of described adlay extract is：
Adlay is cleaned, crushed, 10 times of weight waters is then added, is placed in extraction equipment, 5h is decocted, decoction liquor is true
Sky is dried, and is produced.
In the present invention, the adlay extract is purchased from Xi'an Yuan Sen bio tech ltd.
Notogineng Extract
In the present invention, the Notogineng Extract is purchased from Xi'an Yuan Sen bio tech ltd.
Gold engraves leaf of plum extract
In the present invention, the gold engraves leaf of plum extract and is purchased from Xi'an Tong Ze bio tech ltd.
Camomile extract
In the present invention, the camomile extract is purchased from Xi'an Chang Yue bio tech ltd.
Milk thistle extract
In the present invention, the milk thistle extract is purchased from Xi'an Chang Yue bio tech ltd.
Gotu Kola P.E
In the present invention, the Gotu Kola P.E is purchased from Xi'an Chang Yue bio tech ltd.
Elderberry extract
In the present invention, the elderberry extract is purchased from Xi'an Chang Yue bio tech ltd.
Fructus Cucumidis sativi extract
In the present invention, the Fructus Cucumidis sativi extract is purchased from Xi'an Chang Yue bio tech ltd.
Gadol extract
In the present invention, the gadol extract is purchased from Xi'an Chang Yue bio tech ltd.
Wolfberry fruit extract
In the present invention, the wolfberry fruit extract is purchased from Xi'an Yuan Sen bio tech ltd.
Seabuckthorn Oil
In the present invention, the Seabuckthorn Oil is purchased from Mei Ji international corporation.
Herba Lysimachiae foenumgraeci extract
In the present invention, the Herba Lysimachiae foenumgraeci extract is purchased from Xi'an Yuan Sen bio tech ltd.
As a kind of preferred technical scheme of the present invention, the whitening, which highlights composition, also includes the fowler of 0.1 parts by weight
Alkene activity liquid.
In the present invention, the active liquid of the fullerene is purchased from Suzhou great virtue carbon nanosecond science and technology Co., Ltd.
As a kind of preferred technical scheme of the present invention, the whitening highlights the preparation that composition is following form：Creme,
Granule, ointment, foaming agent, lotion, emplastrum, tablet, emulsion.
The second aspect of the invention provides the preparation method that a kind of whitening highlights composition, at least comprises the following steps：
(1) by deionized water, spikemoss extract, tomato extract, ambrette seed extract, hydrolysis hyaluronic acid, glycyrrhizic acid
Dipotassium is mixed, after being stirred at 30 DEG C, is added hyaluronic acid, acetyl chitosamine keeping temperature and is continued to stir after 30min, obtains
To the first product；
(2) Megranate Seed P.E, hyperici,herba extract, Fructus Luffae extract, alpha-arbutin, adlay extract, pseudo-ginseng are carried
Thing, gold is taken to engrave leaf of plum extract, camomile extract, milk thistle extract, Gotu Kola P.E, elderberry extract, cucumber
Extract, gadol extract, wolfberry fruit extract, Seabuckthorn Oil, Herba Lysimachiae foenumgraeci extract mix 60min at room temperature, then add
Enter the active liquid of pomegranate, Selaginella tamariscina, the extract microcapsules of radix glycyrrhizae mixture, fullerene and stir 30min at 50 DEG C, be cooled to room temperature
Obtain the second product；
(3) the second product is all instilled in the first product, deposits 24h at -5 DEG C, obtain whitening and highlight composition.
The third aspect of the invention highlights application of the composition in skin conditioning agent field there is provided whitening.
Embodiment 1：Embodiment 1 highlights composition there is provided a kind of whitening, in parts by weight, and its raw material is at least wrapped
Include：20~60 parts of spikemoss extract, 10~30 parts of tomato extract, 3~10 parts of ambrette seed extract, acetyl chitosamine 5~20
Part, 3~18 parts of hyaluronic acid, 1~10 part of hyaluronic acid of hydrolysis, 1~8 part of dipotassium glycyrrhizinate, 10~30 parts of deionized water.
Embodiment 2：Embodiment 2 is identical with embodiment 1, and difference is, the whitening highlights composition, with weight
Part meter is measured, its raw material at least includes：40~50 parts of spikemoss extract, 20~25 parts of tomato extract, ambrette seed extract 5~8
Part, 15~20 parts of acetyl chitosamine, 10~15 parts of hyaluronic acid, hydrolysis 5~8 parts of hyaluronic acid, 5~7 parts of dipotassium glycyrrhizinate, go
20~30 parts of ionized water.
Embodiment 3：Embodiment 3 is identical with embodiment 2, and difference is, the whitening highlights composition, with weight
Part meter is measured, its raw material at least includes：45 parts of spikemoss extract, 25 parts of tomato extract, 6 parts of ambrette seed extract, acetyl chitose
18 parts of amine, 13 parts of hyaluronic acid, 6 parts of hyaluronic acid of hydrolysis, 6 parts of dipotassium glycyrrhizinate, 30 parts of deionized water.
Embodiment 4：Embodiment 4 is identical with embodiment 1, and difference is, the whitening highlights composition, with weight
Part meter is measured, its raw material also includes：
Pomegranate, Selaginella tamariscina, 8 parts of 20 parts of extract microcapsules, Megranate Seed P.E, the hyperici,herba extract 5 of radix glycyrrhizae mixture
Part, 10 parts of Fructus Luffae extract, 10 parts of alpha-arbutin, 12 parts of adlay extract, 8 parts of Notogineng Extract, gold engrave leaf of plum extract 15
Part, 6 parts of camomile extract, 4 parts of milk thistle extract, 10 parts of Gotu Kola P.E, 7 parts of elderberry extract, cucumber are extracted
5 parts of thing, 8 parts of gadol extract, 4 parts of wolfberry fruit extract, 3 parts of Seabuckthorn Oil, 4 parts of Herba Lysimachiae foenumgraeci extract.
Embodiment 5：Embodiment 5 is identical with embodiment 4, and difference is, the pomegranate, Selaginella tamariscina, radix glycyrrhizae mixing
In thing, the weight ratio between pomegranate, Selaginella tamariscina, radix glycyrrhizae is：100：(1~20)：(1~5).
Embodiment 6：Embodiment 6 is identical with embodiment 4, and difference is, the pomegranate, Selaginella tamariscina, radix glycyrrhizae mixing
The preparation method of the extract microcapsules of thing is as follows：
Weigh after pomegranate, Selaginella tamariscina, radix glycyrrhizae mixing, crushed, obtain 50g raw materials, it is 50% to add 300g mass fractions
Ethanol solution, while adding the active liquid of 0.01g fullerenes into ethanol solution, at 40 DEG C, ultrasonic 60min obtains first and carried
Take thing；
Weigh 10g cyst materials to be dissolved in 50g distilled water, treat cyst material all dissolvings, and add 6g at room temperature
First extract, stirs, ultrasonic 30min, is well mixed it, in 175 DEG C of inlet temperature, feed rate 3mL/min, spray
It is spray-dried under the conditions of 2 times/min of mouth diameter 0.7mm and nozzle cleaning, obtains pomegranate, Selaginella tamariscina, radix glycyrrhizae mixture and carry
Take thing microcapsules；
The cyst material is：Chitosan and ultrabranching polyamide compound, the mixture of Arabic gum；Chitosan is with surpassing
Weight ratio between branched polyamide compound, Arabic gum is 1：1.
Embodiment 7：Embodiment 7 is identical with embodiment 1, and difference is, the whitening highlights composition and also wrapped
Include the active liquid of fullerene of 0.1 parts by weight.
Embodiment 8：Embodiment 8 is identical with embodiment 1~7, and difference is, the whitening highlights composition and is
The preparation of following form：Creme, granule, ointment, foaming agent, lotion, emplastrum, tablet, emulsion.
Embodiment 9：Embodiment 9 is the preparation method of embodiment 4, and the whitening highlights the preparation side of composition
Method, at least comprises the following steps：
(1) by deionized water, spikemoss extract, tomato extract, ambrette seed extract, hydrolysis hyaluronic acid, glycyrrhizic acid
Dipotassium is mixed, after being stirred at 30 DEG C, is added hyaluronic acid, acetyl chitosamine keeping temperature and is continued to stir after 30min, obtains
To the first product；
(2) Megranate Seed P.E, hyperici,herba extract, Fructus Luffae extract, alpha-arbutin, adlay extract, pseudo-ginseng are carried
Thing, gold is taken to engrave leaf of plum extract, camomile extract, milk thistle extract, Gotu Kola P.E, elderberry extract, cucumber
Extract, gadol extract, wolfberry fruit extract, Seabuckthorn Oil, Herba Lysimachiae foenumgraeci extract mix 60min at room temperature, then add
Enter the active liquid of pomegranate, Selaginella tamariscina, the extract microcapsules of radix glycyrrhizae mixture, fullerene and stir 30min at 50 DEG C, be cooled to room temperature
Obtain the second product；
(3) the second product is all instilled in the first product, deposits 24h at -5 DEG C, obtain whitening and highlight composition.
Embodiment 10：Embodiment 10 is that the whitening described in embodiment 1~7 highlights composition in skin conditioning agent neck
Application in domain.
The present invention is specifically described below by embodiment.It is necessarily pointed out that, following examples are only used
In the invention will be further described, it is impossible to be interpreted as limiting the scope of the invention, professional and technical personnel in the field
Some the nonessential modifications and adaptations made according to the content of the invention described above, still fall within protection scope of the present invention.
In addition, if without other explanations, raw materials used is all commercially available.
Embodiment
Embodiment 1
The present embodiment 1 highlights composition there is provided a kind of whitening, in parts by weight, and its raw material at least includes：Selaginella tamariscina is extracted
20 parts of thing, 10 parts of tomato extract, 3 parts of ambrette seed extract, 5 parts of acetyl chitosamine, 3 parts of hyaluronic acid, hydrolysis hyaluronic acid 1
Part, 1 part of dipotassium glycyrrhizinate, 10 parts of deionized water.
The spikemoss extract, tomato extract are purchased from the Hao Bo bio tech ltd of Shanghai hundred；
The ambrette seed extract is purchased from Miao Sen international corporation；
The acetyl chitosamine, hyaluronic acid, hydrolysis hyaluronic acid are purchased from Bloomage Freda Biopharm Co., Ltd.；
The dipotassium glycyrrhizinate is purchased from Ke Sifa international trades (Shanghai) Co., Ltd. Beijing Company；
The whitening highlights the preparation method of composition, at least comprises the following steps：
By deionized water, spikemoss extract, tomato extract, ambrette seed extract, hydrolysis hyaluronic acid, dipotassium glycyrrhizinate
Mixing, after being stirred at 30 DEG C, adds hyaluronic acid, acetyl chitosamine keeping temperature and continues to stir after 30min, obtain institute
State whitening and highlight composition.
Embodiment 2
The present embodiment 2 highlights composition there is provided a kind of whitening, in parts by weight, and its raw material at least includes：Selaginella tamariscina is extracted
60 parts of thing, 30 parts of tomato extract, 10 parts of ambrette seed extract, 20 parts of acetyl chitosamine, 18 parts of hyaluronic acid, hydrolysis hyalomitome
10 parts of acid, 8 parts of dipotassium glycyrrhizinate, 30 parts of deionized water.
The spikemoss extract, tomato extract are purchased from the Hao Bo bio tech ltd of Shanghai hundred；
The ambrette seed extract is purchased from Miao Sen international corporation；
The acetyl chitosamine, hyaluronic acid, hydrolysis hyaluronic acid are purchased from Bloomage Freda Biopharm Co., Ltd.；
The dipotassium glycyrrhizinate is purchased from Ke Sifa international trades (Shanghai) Co., Ltd. Beijing Company；
The whitening highlights the preparation method of composition, at least comprises the following steps：
By deionized water, spikemoss extract, tomato extract, ambrette seed extract, hydrolysis hyaluronic acid, dipotassium glycyrrhizinate
Mixing, after being stirred at 30 DEG C, adds hyaluronic acid, acetyl chitosamine keeping temperature and continues to stir after 30min, obtain institute
State whitening and highlight composition.
Embodiment 3
The present embodiment 3 highlights composition there is provided a kind of whitening, in parts by weight, and its raw material at least includes：Selaginella tamariscina is extracted
40 parts of thing, 20 parts of tomato extract, 5 parts of ambrette seed extract, 15 parts of acetyl chitosamine, 10 parts of hyaluronic acid, hydrolysis hyalomitome
5 parts of acid, 5 parts of dipotassium glycyrrhizinate, 20 parts of deionized water.
The spikemoss extract, tomato extract are purchased from the Hao Bo bio tech ltd of Shanghai hundred；
The ambrette seed extract is purchased from Miao Sen international corporation；
The acetyl chitosamine, hyaluronic acid, hydrolysis hyaluronic acid are purchased from Bloomage Freda Biopharm Co., Ltd.；
The dipotassium glycyrrhizinate is purchased from Ke Sifa international trades (Shanghai) Co., Ltd. Beijing Company；
The whitening highlights the preparation method of composition, at least comprises the following steps：
By deionized water, spikemoss extract, tomato extract, ambrette seed extract, hydrolysis hyaluronic acid, dipotassium glycyrrhizinate
Mixing, after being stirred at 30 DEG C, adds hyaluronic acid, acetyl chitosamine keeping temperature and continues to stir after 30min, obtain institute
State whitening and highlight composition.
Embodiment 4
The present embodiment 4 highlights composition there is provided a kind of whitening, in parts by weight, and its raw material at least includes：Selaginella tamariscina is extracted
50 parts of thing, 25 parts of tomato extract, 8 parts of ambrette seed extract, 20 parts of acetyl chitosamine, 15 parts of hyaluronic acid, hydrolysis hyalomitome
8 parts of acid, 7 parts of dipotassium glycyrrhizinate, 30 parts of deionized water.
The spikemoss extract, tomato extract are purchased from the Hao Bo bio tech ltd of Shanghai hundred；
The ambrette seed extract is purchased from Miao Sen international corporation；
The acetyl chitosamine, hyaluronic acid, hydrolysis hyaluronic acid are purchased from Bloomage Freda Biopharm Co., Ltd.；
The dipotassium glycyrrhizinate is purchased from Ke Sifa international trades (Shanghai) Co., Ltd. Beijing Company；
The whitening highlights the preparation method of composition, at least comprises the following steps：
By deionized water, spikemoss extract, tomato extract, ambrette seed extract, hydrolysis hyaluronic acid, dipotassium glycyrrhizinate
Mixing, after being stirred at 30 DEG C, adds hyaluronic acid, acetyl chitosamine keeping temperature and continues to stir after 30min, obtain institute
State whitening and highlight composition.
Embodiment 5
The present embodiment 5 highlights composition there is provided a kind of whitening, in parts by weight, and its raw material at least includes：Selaginella tamariscina is extracted
45 parts of thing, 25 parts of tomato extract, 6 parts of ambrette seed extract, 18 parts of acetyl chitosamine, 13 parts of hyaluronic acid, hydrolysis hyalomitome
6 parts of acid, 6 parts of dipotassium glycyrrhizinate, 30 parts of deionized water.
The spikemoss extract, tomato extract are purchased from the Hao Bo bio tech ltd of Shanghai hundred；
The ambrette seed extract is purchased from Miao Sen international corporation；
The acetyl chitosamine, hyaluronic acid, hydrolysis hyaluronic acid are purchased from Bloomage Freda Biopharm Co., Ltd.；
The dipotassium glycyrrhizinate is purchased from Ke Sifa international trades (Shanghai) Co., Ltd. Beijing Company；
The whitening highlights the preparation method of composition, at least comprises the following steps：
By deionized water, spikemoss extract, tomato extract, ambrette seed extract, hydrolysis hyaluronic acid, dipotassium glycyrrhizinate
Mixing, after being stirred at 30 DEG C, adds hyaluronic acid, acetyl chitosamine keeping temperature and continues to stir after 30min, obtain institute
State whitening and highlight composition.
Embodiment 6
The present embodiment 6 highlights composition there is provided a kind of whitening, in parts by weight, and its raw material includes：Spikemoss extract 45
Part, 25 parts of tomato extract, 6 parts of ambrette seed extract, 18 parts of acetyl chitosamine, 13 parts of hyaluronic acid, hydrolysis hyaluronic acid 6
Part, 6 parts of dipotassium glycyrrhizinate, 30 parts of deionized water, pomegranate, Selaginella tamariscina, 20 parts of the extract microcapsules of radix glycyrrhizae mixture, pomegranate seed are carried
Take 8 parts of thing, 5 parts of hyperici,herba extract, 10 parts of Fructus Luffae extract, 10 parts of alpha-arbutin, 12 parts of adlay extract, Notogineng Extract
8 parts, gold engrave 15 parts of leaf of plum extract, 6 parts of camomile extract, 4 parts of milk thistle extract, 10 parts of Gotu Kola P.E, synthetism
Wooden 7 parts of extract, 5 parts of Fructus Cucumidis sativi extract, 8 parts of gadol extract, 4 parts of wolfberry fruit extract, 3 parts of Seabuckthorn Oil, lavender are extracted
4 parts of thing.
The spikemoss extract, tomato extract are purchased from the Hao Bo bio tech ltd of Shanghai hundred；
The ambrette seed extract is purchased from Miao Sen international corporation；
The acetyl chitosamine, hyaluronic acid, hydrolysis hyaluronic acid are purchased from Bloomage Freda Biopharm Co., Ltd.；
The dipotassium glycyrrhizinate is purchased from Ke Sifa international trades (Shanghai) Co., Ltd. Beijing Company；
The Megranate Seed P.E is purchased from Lanzhou water Lai Si bio tech ltd；
The hyperici,herba extract is purchased from Xi'an Ao Ruite bio tech ltd；
The Fructus Luffae extract is purchased from the big magnificent great achievement medication chemistry Co., Ltd in Wuhan；
The alpha-arbutin is purchased from Suzhou great virtue carbon nanosecond science and technology Co., Ltd；
The adlay extract is purchased from Xi'an Yuan Sen bio tech ltd；
The Notogineng Extract is purchased from Xi'an Yuan Sen bio tech ltd；
The gold engraves leaf of plum extract and is purchased from Xi'an Tong Ze bio tech ltd；
The camomile extract is purchased from Xi'an Chang Yue bio tech ltd；
The milk thistle extract is purchased from Xi'an Chang Yue bio tech ltd；
The Gotu Kola P.E is purchased from Xi'an Chang Yue bio tech ltd；
The elderberry extract is purchased from Xi'an Chang Yue bio tech ltd；
The Fructus Cucumidis sativi extract is purchased from Xi'an Chang Yue bio tech ltd；
The gadol extract is purchased from Xi'an Chang Yue bio tech ltd；
The wolfberry fruit extract is purchased from Xi'an Yuan Sen bio tech ltd；
The Seabuckthorn Oil is purchased from Mei Ji international corporation；
The Herba Lysimachiae foenumgraeci extract is purchased from Xi'an Yuan Sen bio tech ltd.
The pomegranate, Selaginella tamariscina, the extract microcapsules of radix glycyrrhizae mixture preparation method it is as follows：
Weigh after pomegranate, Selaginella tamariscina, radix glycyrrhizae mixing, crushed, obtain 50g raw materials, it is 50% to add 300g mass fractions
Ethanol solution, while adding the active liquid of 0.01g fullerenes into ethanol solution, at 40 DEG C, ultrasonic 60min obtains first and carried
Take thing；
Weigh 10g cyst materials to be dissolved in 50g distilled water, treat cyst material all dissolvings, and add 6g at room temperature
First extract, stirs, ultrasonic 30min, is well mixed it, in 175 DEG C of inlet temperature, feed rate 3mL/min, spray
It is spray-dried under the conditions of 2 times/min of mouth diameter 0.7mm and nozzle cleaning, obtains pomegranate, Selaginella tamariscina, radix glycyrrhizae mixture and carry
Take thing microcapsules；
The cyst material is：Chitosan and ultrabranching polyamide compound, the mixture of Arabic gum；Chitosan is with surpassing
Weight ratio between branched polyamide compound, Arabic gum is 1：1.
The preparation method of the chitosan and ultrabranching polyamide compound, at least comprises the following steps：
5g dodecanedioic acid is dissolved in 20mL dimethyl sulfoxide (DMSO)s and obtains dodecanedioic acid solution；15g shell is gathered
Sugar is dissolved in 50mL dimethyl sulfoxide (DMSO)s and obtains chitosan solution；15g ultrabranching polyamide is dissolved in 50mL dimethyl sub-
Ultrabranching polyamide solution is obtained in sulfone；Then dodecanedioic acid solution is added in reactor, stirred, keeping temperature 50
DEG C, cool after then adding chitosan solution, reaction 3h, you can obtain dodecanedioic acid modification of chitosan；Then to 12
Ultrabranching polyamide solution is added in docosandioic acid modification of chitosan, at 60 DEG C, continues to react cooling after 2h, washs, dries, i.e.,
It can obtain chitosan and ultrabranching polyamide compound.
The whitening highlights the preparation method of composition, at least comprises the following steps：
By deionized water, spikemoss extract, tomato extract, ambrette seed extract, hydrolysis hyaluronic acid, dipotassium glycyrrhizinate
Mixing, after being stirred at 30 DEG C, adds hyaluronic acid, acetyl chitosamine keeping temperature and continues to stir after 30min, obtain institute
State whitening and highlight composition.
Embodiment 7
The be the same as Example 6 of the present embodiment 7, difference is, the fullerene of 0.1 parts by weight is also included in the formula of embodiment 7
Active liquid.The active liquid of the fullerene is purchased from Suzhou great virtue carbon nanosecond science and technology Co., Ltd.
Comparative example 1
The be the same as Example 6 of comparative example 1, difference is, not including pomegranate, Selaginella tamariscina, radix glycyrrhizae mixture extract microcapsules.
Comparative example 2
The be the same as Example 6 of comparative example 2, difference is, the extract microcapsules of pomegranate, Selaginella tamariscina, radix glycyrrhizae mixture are changed
Into pomegranate, Selaginella tamariscina, radix glycyrrhizae mixture extract, without being prepared into microcapsules.Wherein, pomegranate, Selaginella tamariscina, radix glycyrrhizae mixture are carried
Take the preparation process be the same as Example 6 of thing.
Comparative example 3
The be the same as Example 6 of comparative example 3, difference is, the extract microcapsules of pomegranate, Selaginella tamariscina, radix glycyrrhizae mixture are changed
Into Punica granatum L. extract microcapsules.Wherein, the preparation process be the same as Example 6 of Punica granatum L. extract microcapsules, simply include radix glycyrrhizae and
Selaginella tamariscina.
Comparative example 4
The be the same as Example 6 of comparative example 4, difference is, the extract microcapsules of pomegranate, Selaginella tamariscina, radix glycyrrhizae mixture are changed
Into licorice microcapsules.Wherein, the preparation process be the same as Example 6 of licorice microcapsules, simply include Selaginella tamariscina and
Pomegranate.
Comparative example 5
The be the same as Example 6 of comparative example 5, difference is, the extract microcapsules of pomegranate, Selaginella tamariscina, radix glycyrrhizae mixture are changed
Into Selaginella tamariscina extract microcapsules.Wherein, the preparation process be the same as Example 6 of spikemoss extract microcapsules, simply include pomegranate and
Radix glycyrrhizae.
Comparative example 6
The be the same as Example 6 of comparative example 6, difference is, by pomegranate, Selaginella tamariscina, the extract microcapsules of radix glycyrrhizae mixture
Cyst wall is replaced with Arabic gum.
Comparative example 7
The be the same as Example 6 of comparative example 7, difference is, by pomegranate, Selaginella tamariscina, the extract microcapsules of radix glycyrrhizae mixture
Cyst wall is replaced with chitosan.
Comparative example 8
The be the same as Example 6 of comparative example 8, difference is, by pomegranate, Selaginella tamariscina, the extract microcapsules of radix glycyrrhizae mixture
The weight ratio that cyst wall is replaced between chitosan, Arabic gum, and chitosan, Arabic gum is 1：1.
Comparative example 9
The be the same as Example 6 of comparative example 9, difference is, by pomegranate, Selaginella tamariscina, the extract microcapsules of radix glycyrrhizae mixture
Cyst wall is replaced with ultrabranching polyamide.
Comparative example 10
The be the same as Example 6 of comparative example 10, difference is, by pomegranate, Selaginella tamariscina, the extract microcapsules of radix glycyrrhizae mixture
Cyst wall is replaced with chitosan and ultrabranching polyamide compound.
Comparative example 11
The be the same as Example 6 of comparative example 11, difference is, by pomegranate, Selaginella tamariscina, the extract microcapsules of radix glycyrrhizae mixture conjunction
During, the active liquid of fullerene is added without.
Performance test
1st, tyrosinase inhibitory activity is tested
Experimental method (with reference to " Wei Zhen holds Guangzhou Food Industries science and technology .Vol.20No.3, P10-11 ")：10ml is taken respectively
Embodiment 1~7 and the whitening of comparative example 1~11 highlight composition, and with phosphate buffer (pH=6.8) sample dissolution,
Every kind of sample is each configured to the sample that concentration is 1mg/ml to be measured.
2ml (blank group is with phosphate buffer replacement) is respectively taken to add tyrosinase (100U) in each test group, at 37 DEG C
10min is heated in Water Tank with Temp.-controlled, 0.003mol/L dopa reaction liquid 1ml is added, is sufficiently stirred for, it is anti-in 37 DEG C (waters bath with thermostatic control)
Answer after 2min, take out immediately, determine the absorbance at 475nm.
Inhibiting rate={ [(A-B)-(C-D)]/(A-B) } * 100%；
A is not to be loaded the absorbance that the mixed liquor of product plus tyrosinase is measured at 475nm；B is not to be loaded product and do not add
The absorbance that the mixed liquor of tyrosinase is measured at 475nm；C surveys for the mixed liquor of sample-adding product and tyrosinase at 475nm
The absorbance obtained；D does not add the absorbance that the mixed liquor of tyrosinase is measured at 475nm for sample-adding product.
The whitening effect evaluation table of table 1
The present invention product for tyrosinase inhibition rate have higher inhibiting rate, illustrate the present invention product with compared with
Good whitening effect.
2nd, bacteriostasis property evaluation
Due to air pollutions such as hazes so that in air, Escherichia coli, staphylococcus aureus, propionibacterium acnes connect
Tactile skin easily causes the phenomenons such as skin acne, sensitivity.
Bacteriostasis property evaluation reference Chinese Patent Application No. in the application：CN201510395607.9.
Odontothrips loti：Corresponding culture medium, 121 DEG C of high pressure steam sterilization, 20min are configured according to different strains testeds.Make
Solid medium flat board, each culture dish about pours into 20mL culture mediums, after after culture medium solidifying, taking 100 μ L bacterium solutions with liquid-transfering gun
(by the bacteria suspension of Maxwell turbidimetry for Determination concentration) is instilled in culture dish, and using spread plate, bacteria suspension is uniformly applied
It is distributed on solid medium.Media surface directly vertically put Oxford cup (internal diameter 6mm, external diameter 8mm, high 10mm circle
Tubule), gently pressurize, it is contacted tight with culture medium.Each culture dish places three Oxford cups.Add in each Oxford cup
Enter 200 μ L testing samples, the culture dish of bacterium is gently placed in bacteriological incubator or so 37 DEG C of cultures, 16 hours.
Note：Antibacterial circle diameter >=30mm has been judged to very good bacteriostasis, antibacterial circle diameter 20mm for extremely sensitive " ++++"
≤ bacteriostatic diameter<30mm has been judged to bacteriostasis, 15mm≤bacteriostatic diameter for extremely sensitive " +++ "<20mm is Gao Min " ++ "；10mm
≤ bacteriostatic diameter<15mm quick "+" in being；Bacteriostatic diameter<10mm is invalid, is judged to no bacteriostasis.Wherein, the bigger suppression of inhibition zone
Bacterium effect is better.
The fungistatic effect evaluation table of table 2
The product of the present invention is for the Escherichia coli, staphylococcus aureus, acne third that occur in the air pollutions such as haze
Acidfast bacilli has preferable fungistatic effect.
3rd, moisture retention effect assessment
Test philosophy：According to composition moisture absorption, the difference of performance of keeping humidity, the active force of different moisturizing agent molecule to hydrone
Difference, absorbs moisture different with the ability of moisture is kept.Oil content has sealing process to moisture, can prevent scattering and disappearing for moisture.Moisture absorption
Active force is big, strong to water molecules power, absorbs and keeps the amount of moisture also than larger, closure is good, moisture loss
Also it is few.The biomaterial of cuticula, epidermis etc. is imitated using adhesive tape, cosmetics are coated with adhesive tape, practical application situation is simulated.
Sample is placed under conditions of constant humidity after certain time, weighs of poor quality before and after putting, is obtained the loss of sample size, can be calculated
The effect of moisturizing ingredient moisturizing.It is shown in Table 5.
Moisturizing rate calculation formula：Moisturizing rate=(M2–M0)/(M1–M0) × 100%
In formula：
M0：Hollow plate quality/g；
M1：Glass sheet quality/g after sample-adding；
M2：Quality/g after some hours is placed in drier；
Test its relative humidity be 60% when 4h and 10h in moisturizing rate；
The moisture retention test result of table 3
4th, physical and chemical index is tested
Sensory testing：The character of product is visually observed, exception is seen if there is；
Resistance to Thermal test：Sample is put into 24h in the electro-heating standing-temperature cultivator of (40 ± 1) DEG C, seen whether after recovering room temperature
There are the phenomenons such as thinning, discoloration, layering and firmness change, with the heat resistance of judgement sample；
Low temperature resistant test：Sample is put into 24h in the refrigerator of (- 5~-10) DEG C ± 1 DEG C, seen whether after recovering room temperature
The phenomenons such as thinning, discoloration, layering and firmness change, with the cold tolerance of judgement sample；
Centrifugal test：Sample is placed in a centrifuge, with (2000~4000) r/min speed test 30min, sample is observed
The separation of product, layering situation.
The physical and chemical index result of table 4
Choose 200 volunteers, women, the age in 20 one full year of life between 50 one full year of life, wherein, 100 entitled live in for a long time
The heavier city of haze, volunteer face due to air pollutions such as pressure, the haze of life etc. cause face dry, rise acne,
The colour of skin is obscure.Volunteer is sooner or later each daily to highlight composition once using whitening, and each consumption 5ml is uniformly applied to face, held
It is continuous to use 1 month, observe the change situation of skin of face.As a result show, 100% volunteer's skin of face occurs bleaching, carried
Bright effect；99% volunteer's skin of face occurs stopping long acne phenomenon；100% volunteer's skin of face has preferable guarantor
Wet effect.
Foregoing example is merely illustrative, some features of the feature for explaining the disclosure.Appended claim
The scope as wide as possible for requiring to be contemplated that is intended to, and embodiments as presented herein is only according to all possible embodiment
Combination selection embodiment explanation.Therefore, the purpose of applicant is appended claim not by the explanation present invention
Feature example selectional restriction.And the progress in science and technology by formed language performance it is inaccurate due to and not
The possible equivalent or son being presently considered are replaced, and these changes should also be interpreted by appended in the conceived case
Claim is covered.
Claims (10)
1. a kind of whitening highlights composition, it is characterised in that in parts by weight, its raw material at least includes：Spikemoss extract 20~
60 parts, 10~30 parts of tomato extract, 3~10 parts of ambrette seed extract, 5~20 parts of acetyl chitosamine, hyaluronic acid 3~18
Part, 1~10 part of hyaluronic acid of hydrolysis, 1~8 part of dipotassium glycyrrhizinate, 10~30 parts of deionized water.
2. whitening as claimed in claim 1 highlights composition, it is characterised in that the whitening highlights composition, with parts by weight
Meter, its raw material at least includes：40~50 parts of spikemoss extract, 20~25 parts of tomato extract, 5~8 parts of ambrette seed extract, second
15~20 parts of acyl chitosamine, 10~15 parts of hyaluronic acid, 5~8 parts of hyaluronic acid of hydrolysis, 5~7 parts of dipotassium glycyrrhizinate, deionization
20~30 parts of water.
3. whitening as claimed in claim 2 highlights composition, it is characterised in that in parts by weight, its raw material at least includes：Volume
45 parts of cypress extract, 25 parts of tomato extract, 6 parts of ambrette seed extract, 18 parts of acetyl chitosamine, 13 parts of hyaluronic acid, hydrolysis
6 parts of hyaluronic acid, 6 parts of dipotassium glycyrrhizinate, 30 parts of deionized water.
4. the whitening as described in claims 1 to 3 any one highlights composition, it is characterised in that the whitening highlights combination
Thing, in parts by weight, its raw material also include：
Pomegranate, Selaginella tamariscina, 8 parts of 20 parts of extract microcapsules, the Megranate Seed P.E of radix glycyrrhizae mixture, hyperici,herba extract 5 part, thread
10 parts of melon extract, 10 parts of alpha-arbutin, 12 parts of adlay extract, 8 parts of Notogineng Extract, gold engrave 15 parts of leaf of plum extract, ocean
6 parts of Flos Chrysanthemi extract, 4 parts of milk thistle extract, 10 parts of Gotu Kola P.E, 7 parts of elderberry extract, 5 parts of Fructus Cucumidis sativi extract,
8 parts of gadol extract, 4 parts of wolfberry fruit extract, 3 parts of Seabuckthorn Oil, 4 parts of Herba Lysimachiae foenumgraeci extract.
5. whitening as claimed in claim 4 highlights composition, it is characterised in that in the pomegranate, Selaginella tamariscina, radix glycyrrhizae mixture,
Weight ratio between pomegranate, Selaginella tamariscina, radix glycyrrhizae is：100：(1~20)：(1~5).
6. whitening as claimed in claim 4 highlights composition, it is characterised in that the pomegranate, Selaginella tamariscina, radix glycyrrhizae mixture are carried
Take the preparation method of thing microcapsules as follows：
Weigh after pomegranate, Selaginella tamariscina, radix glycyrrhizae mixing, crushed, obtain 50g raw materials, it is 50% ethanol to add 300g mass fractions
Solution, while adding the active liquid of 0.01g fullerenes into ethanol solution, at 40 DEG C, ultrasonic 60min obtains the first extract；
Weigh 10g cyst materials to be dissolved in 50g distilled water, treat cyst material all dissolvings, and add 6g first at room temperature
Extract, stirs, ultrasonic 30min, is well mixed it, in 175 DEG C of inlet temperature, feed rate 3mL/min, nozzle head
It is spray-dried under the conditions of 2 times/min of diameter 0.7mm and nozzle cleaning, obtains pomegranate, Selaginella tamariscina, the extract of radix glycyrrhizae mixture
Microcapsules；
The cyst material is：Chitosan and ultrabranching polyamide compound, the mixture of Arabic gum；Chitosan with it is hyperbranched
Weight ratio between polyamide compound, Arabic gum is 1：1.
7. whitening as claimed in claim 1 highlights composition, it is characterised in that the whitening, which highlights composition, also includes 0.1
The active liquid of the fullerene of parts by weight.
8. the whitening as described in claim 1~7 highlights composition, it is characterised in that it is following that the whitening, which highlights composition,
The preparation of form：Creme, granule, ointment, foaming agent, lotion, emplastrum, tablet, emulsion.
9. whitening as claimed in claim 4 highlights composition, it is characterised in that the whitening highlights the preparation side of composition
Method, at least comprises the following steps：
(1) by deionized water, spikemoss extract, tomato extract, ambrette seed extract, hydrolysis hyaluronic acid, dipotassium glycyrrhizinate
Mixing, after being stirred at 30 DEG C, adds hyaluronic acid, acetyl chitosamine keeping temperature and continues to stir after 30min, obtain the
One product；
(2) by Megranate Seed P.E, hyperici,herba extract, Fructus Luffae extract, alpha-arbutin, adlay extract, Notogineng Extract,
Gold is engraved leaf of plum extract, camomile extract, milk thistle extract, Gotu Kola P.E, elderberry extract, cucumber and extracted
Thing, gadol extract, wolfberry fruit extract, Seabuckthorn Oil, Herba Lysimachiae foenumgraeci extract mix 60min at room temperature, add stone
The active liquid of pomegranate, Selaginella tamariscina, the extract microcapsules of radix glycyrrhizae mixture, fullerene stirs 30min at 50 DEG C, is cooled to room temperature and obtains
Second product；
(3) the second product is all instilled in the first product, deposits 24h at -5 DEG C, obtain whitening and highlight composition.
10. the whitening as described in claim 1~7 highlights application of the composition in skin conditioning agent field.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108379099A (en) * | 2018-04-23 | 2018-08-10 | 广州雷诺生物科技有限公司 | A kind of skin whitener containing fullerene |
| CN108578263A (en) * | 2018-06-20 | 2018-09-28 | 吉林农业科技学院 | Silymarin Skin whitening care cosmetics |
| CN109512735A (en) * | 2018-01-10 | 2019-03-26 | 北京东方淼森生物科技有限公司 | Have effects that exterior-applied plant extract, cosmetics of whitening skin lightening and preparation method thereof |
| CN113975214A (en) * | 2021-11-17 | 2022-01-28 | 浙江大学滨海产业技术研究院 | Whitening and moisturizing composition and preparation method and application thereof |
| CN115414313A (en) * | 2022-10-14 | 2022-12-02 | 佛山天韵化妆品科技有限公司 | Anti-aging composition containing micrococcus lysate and preparation method thereof |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109512735A (en) * | 2018-01-10 | 2019-03-26 | 北京东方淼森生物科技有限公司 | Have effects that exterior-applied plant extract, cosmetics of whitening skin lightening and preparation method thereof |
| CN109512735B (en) * | 2018-01-10 | 2021-04-16 | 北京东方淼森生物科技有限公司 | External plant extract with whitening and skin brightening effects, cosmetic and preparation method thereof |
| CN108379099A (en) * | 2018-04-23 | 2018-08-10 | 广州雷诺生物科技有限公司 | A kind of skin whitener containing fullerene |
| CN108578263A (en) * | 2018-06-20 | 2018-09-28 | 吉林农业科技学院 | Silymarin Skin whitening care cosmetics |
| CN113975214A (en) * | 2021-11-17 | 2022-01-28 | 浙江大学滨海产业技术研究院 | Whitening and moisturizing composition and preparation method and application thereof |
| CN113975214B (en) * | 2021-11-17 | 2023-11-17 | 浙江大学滨海产业技术研究院 | Whitening and moisturizing composition and preparation method and application thereof |
| CN115414313A (en) * | 2022-10-14 | 2022-12-02 | 佛山天韵化妆品科技有限公司 | Anti-aging composition containing micrococcus lysate and preparation method thereof |
| CN115414313B (en) * | 2022-10-14 | 2023-11-14 | 佛山天韵化妆品科技有限公司 | Anti-aging composition containing micrococcus lysate and preparation method thereof |
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