CN107375073A - A kind of anti-inflammatory bacteria inhibiting composition and preparation method thereof - Google Patents
A kind of anti-inflammatory bacteria inhibiting composition and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to plant extracts field, more particularly to a kind of anti-inflammatory bacteria inhibiting composition and preparation method thereof.The anti-inflammatory bacteria inhibiting composition, its raw material comprise at least：30~60 parts of chrysanthemum extract, 10~20 parts of xylitol, 15~20 parts of cholesterine, 10~30 parts of bisabolol, 5~15 parts of ceramide, 10~30 parts of sunflower seed oil.
Description
Technical field
The present invention relates to plant extracts field, more particularly to a kind of anti-inflammatory bacteria inhibiting composition and preparation method thereof.
Background technology
With the acceleration of Development of Urbanization and process of industrialization, paint, grilled coal stove, wood combustion, cigarette combustion,
Vehicle exhaust, industrial waste gas, building building cement dirt, waste incineration, etc. massive discharge of pollutant, cause dust in air, thin
The pollutants such as bacterium, virus, heavy metal (including lead, chromium, cadmium etc.), sulfur dioxide, nitrogen oxides, Carcinogenic Polycyclic Aromatic Hydrocarbons seriously surpass
Mark, they are combined together with fog, allow weather moment to become cloudy gloomy, form haze weather, particularly in recent years, with
Air quality runs down, the frequency more and more higher that haze weather phenomenon occurs, under this weather, when people's trip or daily
During Working Life, the molecule (referring mainly to the particle that diameter is less than or equal to 2.5 microns, i.e. PM2.5) in air will
Grease film layer, the intrusion pore of skin are adhered to when people have no and taken precautions against, at this moment the pollutant in molecule will
Destroy the protective barrier of skin.
The skin organ maximum as human body, make internal various tissues and organ micro- from physics, chemical factor and cause of disease
The invasion and attack of biology, play important barrier and defencive function, while contacted extensively with particulate matter first again, its property and function
Change or damage can to body produce material impact.
Skin is the first line of defence for protecting human body, after the protective barrier of skin is destroyed, can then be occurred a series of
The infringement of the problem of to skin damage, sulfur dioxide and nitrogen oxides to skin is mainly the oxidation of free radical, in skin
The improper free-radical oxidation effect occurred in surface and Skin Cell can accelerate cellular damage and aging.Particulate matter can block
Pore, it is normally metabolic to influence skin, causes the uneven colour of skin, water shortage, sebum discharge to be obstructed and lead acnegenic appearance.
The heavy metal ion adhered on particulate matter can cause the albuminous degeneration of skin, cause pigmentation.Microbes cause skin to be sent out
Raw inflammatory reaction, most commonly by bacterial bacterial dermatosis.And heavy metal ion and microorganism can all cause skin
Skin allergic reaction.
Thus, it is also very desirable to obtain a kind of anti-inflammatory bacteria inhibiting composition, the anti-inflammatory suppression by being formulated the improvement with technique
Bacteria composition inflammation to caused by skin for haze weather, there is good anti-inflammatory fungistatic effect.
The content of the invention
In order to solve the above-mentioned technical problem, the first aspect of the invention provides a kind of anti-inflammatory bacteria inhibiting composition, with weight
Part meter, its raw material comprise at least：30~60 parts of chrysanthemum extract, 10~20 parts of xylitol, 15~20 parts of cholesterine, bisabolol
10~30 parts, 5~15 parts of ceramide, 10~30 parts of sunflower seed oil.
As a kind of preferable technical scheme of the present invention, the anti-inflammatory bacteria inhibiting composition, in parts by weight, its raw material is at least
Including：40~50 parts of chrysanthemum extract, 15~20 parts of xylitol, 15~20 parts of cholesterine, 20~30 parts of bisabolol, neural acyl
10~15 parts of amine, 20~30 parts of sunflower seed oil.
As a kind of preferable technical scheme of the present invention, the anti-inflammatory bacteria inhibiting composition, in parts by weight, its raw material also wraps
Include：Selaginella tamariscina, radix glycyrrhizae, 10 parts of 8 parts of 40 parts of extract microcapsules, spikemoss extract, the Honegsukle flower P.E of banana flowers mixture, one
Branch 15 parts of day lily extract, iris, dandelion mixture 4 parts of 5 parts of 12 parts of extract, green-tea extract, adlay extract,
3 parts of Astragalus Root P.E, 3 parts of Lotus Leafextract, 3 parts of Bilberry fruit P.E, 2 parts of alpha-arbutin, cocamidopropyl propyl amide PG- dimethyl chlorides
Change 7 parts of ammonium phosphate, 2 parts of Seabuckthorn Oil, 0.01 part of fullerene activity liquid.
As a kind of preferable technical scheme of the present invention, the Selaginella tamariscina, radix glycyrrhizae, the extract microcapsules of banana flowers mixture
Extracting method be：
After weighing Selaginella tamariscina, radix glycyrrhizae, banana flowers mixing, crushed, obtain 22g raw materials, adding 200g mass fractions is
60% ethanol solution, while 0.01g fullerene activity liquid is added into ethanol solution, at 50 DEG C, ultrasonic 30min, obtain the
One extract；
Weigh 5g cyst materials to be dissolved in 40g distilled water, treat that cyst material all dissolves, and add 2g the at room temperature
One extract, stirs, ultrasonic 30min, makes it well mixed, in 175 DEG C of inlet temperature, feed rate 3mL/min, nozzle
It is spray-dried under the conditions of head diameter 0.7mm and nozzle cleaning 2 times/min, obtains Selaginella tamariscina, radix glycyrrhizae, banana flowers mixture and carry
Take thing microcapsules；
The cyst material is：Chitosan and ultrabranching polyamide compound, the mixture of Arabic gum；Chitosan is with surpassing
Weight ratio between branched polyamide compound, Arabic gum is 1：1.
As a kind of preferable technical scheme of the present invention, in the Selaginella tamariscina, radix glycyrrhizae, banana flowers mixture, Selaginella tamariscina, radix glycyrrhizae,
Weight ratio between banana flowers is：100：(10~30)：(3~7).
As a kind of preferable technical scheme of the present invention, the iris, dandelion mixture extract preparation side
Method is：
Iris, dandelion are weighed, and is crushed after iris, dandelion are mixed, 15g raw materials is obtained, adds
100g mass fractions are 30% ethanol solution, while 0.01g fullerene activity liquid is added into ethanol solution, at 50 DEG C, are surpassed
Sound 30min, obtain iris, the extract of dandelion mixture.
As a kind of preferable technical scheme of the present invention, in the iris, dandelion mixture, iris, dandelion
Between weight ratio be：(1~8)：50.
As a kind of preferable technical scheme of the present invention, the anti-inflammatory bacteria inhibiting composition is the preparation of following form：Creme,
Granule, ointment, foaming agent, lotion, emplastrum, tablet, emulsion.
The second aspect of the invention provides a kind of preparation method of anti-inflammatory bacteria inhibiting composition, including at least following steps：
(1) deionized water, chrysanthemum extract, xylitol, cholesterine, bisabolol, ceramide are mixed, at 40 DEG C
After stirring, sunflower seed oil is added, keeping temperature continues after stirring 30min, obtains the first product；
(2) Honegsukle flower P.E, Herba Solidaginis extract, iris, the extract of dandelion mixture, green tea are extracted
Thing, adlay extract, Astragalus Root P.E, Lotus Leafextract, Bilberry fruit P.E, alpha-arbutin, cocamidopropyl propyl amide PG- dimethyl
Ammonium chloride phosphate, Seabuckthorn Oil mix 30min at room temperature；Add the extraction of Selaginella tamariscina, radix glycyrrhizae, banana flowers mixture
Thing, spikemoss extract, fullerene activity liquid stir 20min at 60 DEG C, are cooled to room temperature and obtain the second product；
(3) the second product is all instilled in the first product, deposits 24h at -10 DEG C, obtain anti-inflammatory bacteria inhibiting composition.
The third aspect of the invention provides application of the anti-inflammatory bacteria inhibiting composition in skin conditioning agent field.
Embodiment
Unless otherwise defined, all technologies used herein and scientific terminology have and the common skill of art of the present invention
The identical implication that art personnel are generally understood that.When contradiction be present, the definition in this specification is defined.
" quality, concentration, temperature, time or other values or parameter are preferred with scope, preferred scope or a series of upper limits
During the Range Representation that value and lower preferable values limit, this, which is appreciated that, specifically discloses by any range limit or preferred value
All scopes that any pairing with any range lower limit or preferred value is formed, regardless of whether the scope separately discloses.
For example, 1-50 scope is understood to include selected from 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,
19、20、21、22、23、24、25、26、27、28、29、30、31、32、33、34、35、36、37、38、39、40、41、42、43、
44th, 45,46,47,48,49 or 50 any numeral, number combinatorics on words or subrange and all between above-mentioned integer
Fractional value, for example, 1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8 and 1.9.It is specific to consider from scope on subrange
Interior any end points starts " the nested subrange " of extension.For example, exemplary range 1-50 nested subrange can include
1-10,1-20,1-30 and 1-40 on one direction, or 50-40,50-30,50-20 and 50-10 on other direction.”
In order to solve the above-mentioned technical problem, the first aspect of the invention provides a kind of anti-inflammatory bacteria inhibiting composition, with weight
Part meter, its raw material comprise at least：30~60 parts of chrysanthemum extract, 10~20 parts of xylitol, 15~20 parts of cholesterine, bisabolol
10~30 parts, 5~15 parts of ceramide, 10~30 parts of sunflower seed oil.
As a kind of preferable technical scheme of the present invention, the anti-inflammatory bacteria inhibiting composition, in parts by weight, its raw material is at least
Including：40~50 parts of chrysanthemum extract, 15~20 parts of xylitol, 15~20 parts of cholesterine, 20~30 parts of bisabolol, neural acyl
10~15 parts of amine, 20~30 parts of sunflower seed oil.
Chrysanthemum extract
In the present invention, the chrysanthemum extract is purchased from Shanghai Man Run Chemical Industry Science Co., Ltd.
Xylitol
In the present invention, the xylitol is purchased from Zhejiang Huakang Pharmaceutical Co., Ltd.
Cholesterine
In the present invention, the cholesterine is purchased from the conspicuous Industrial Co., Ltd. of sea chart.
Bisabolol
In the present invention, the bisabolol is purchased from the joyful beauty bio tech ltd in Wuhan.
Ceramide
In the present invention, the ceramide is purchased from Shanghai Zhen Zhun bio tech ltd.
Sunflower seed oil
In the present invention, it is refined to cosmetics Co., Ltd that the sunflower seed oil is purchased from Guangzhou.
As a kind of preferable technical scheme of the present invention, the anti-inflammatory bacteria inhibiting composition, in parts by weight, its raw material also wraps
Include：Selaginella tamariscina, radix glycyrrhizae, 10 parts of 8 parts of 40 parts of extract microcapsules, spikemoss extract, the Honegsukle flower P.E of banana flowers mixture, one
Branch 15 parts of day lily extract, iris, dandelion mixture 4 parts of 5 parts of 12 parts of extract, green-tea extract, adlay extract,
3 parts of Astragalus Root P.E, 3 parts of Lotus Leafextract, 3 parts of Bilberry fruit P.E, 2 parts of alpha-arbutin, cocamidopropyl propyl amide PG- dimethyl chlorides
Change 7 parts of ammonium phosphate, 2 parts of Seabuckthorn Oil, 0.01 part of fullerene activity liquid.
Selaginella tamariscina, radix glycyrrhizae, the extract microcapsules of banana flowers mixture
Term " Selaginella tamariscina, radix glycyrrhizae, the extract microcapsules of banana flowers mixture " refers to Selaginella tamariscina, radix glycyrrhizae, banana flowers mixing
The extract of thing is capsule-core, using chitosan and ultrabranching polyamide compound, Arabic gum mixture as wall material.
Term " Selaginella tamariscina, radix glycyrrhizae, the extract of banana flowers mixture " refers to carry out after mixing Selaginella tamariscina, radix glycyrrhizae, banana flowers
Extract obtained Selaginella tamariscina, radix glycyrrhizae, the extract of banana flowers mixture.
Term " chitosan and ultrabranching polyamide compound, the mixture of Arabic gum " refers to chitosan first and end ammonia
Base ultrabranching polyamide first carries out compound, obtains chitosan and amine-terminated hyperbrancedization polyamide compound, then, chitosan with it is super
Branched polyamide compound carries out being mixed to get wall material with Arabic gum.
In a preferred embodiment, the Selaginella tamariscina, radix glycyrrhizae, banana flowers mixture extract microcapsules extraction
Method is：
After weighing Selaginella tamariscina, radix glycyrrhizae, banana flowers mixing, crushed, obtain 22g raw materials, adding 200g mass fractions is
60% ethanol solution, while 0.01g fullerene activity liquid is added into ethanol solution, at 50 DEG C, ultrasonic 30min, obtain the
One extract；
Weigh 5g cyst materials to be dissolved in 40g distilled water, treat that cyst material all dissolves, and add 2g the at room temperature
One extract, stirs, ultrasonic 30min, makes it well mixed, in 175 DEG C of inlet temperature, feed rate 3mL/min, nozzle
It is spray-dried under the conditions of head diameter 0.7mm and nozzle cleaning 2 times/min, obtains Selaginella tamariscina, radix glycyrrhizae, banana flowers mixture and carry
Take thing microcapsules；
The cyst material is：Chitosan and ultrabranching polyamide compound, the mixture of Arabic gum；
The ultrabranching polyamide is amine-terminated hyperbrancedization polyamide, and product grade is：HyPer HPN202, are purchased from Wuhan
Hyperbranched resin Co., Ltd.The chitosan is water soluble chitosan, is purchased from the limited public affairs of Jinan Hai get Bei marine biotechnologies
Department.
Wherein, the weight ratio between chitosan and ultrabranching polyamide compound, Arabic gum is 1：1.
In a preferred embodiment, the preparation method of the chitosan and ultrabranching polyamide compound, at least
Comprise the following steps：
5g dodecanedioic acid is dissolved in 20mL dimethyl sulfoxide (DMSO)s and obtains dodecanedioic acid solution；15g shell is gathered
Sugar is dissolved in 50mL dimethyl sulfoxide (DMSO)s and obtains chitosan solution；15g ultrabranching polyamide is dissolved in 50mL dimethyl Asia
Ultrabranching polyamide solution is obtained in sulfone；Then dodecanedioic acid solution is added in reactor, stirred, keeping temperature 50
DEG C, chitosan solution is then added, is cooled after reacting 3h, you can obtain dodecanedioic acid modification of chitosan；Then to 12
Ultrabranching polyamide solution is added in docosandioic acid modification of chitosan, at 60 DEG C, continues to cool after reacting 2h, washs, dries, i.e.,
It can obtain chitosan and ultrabranching polyamide compound.
Selaginella tamariscina that the present invention designs, radix glycyrrhizae, the extract microcapsules of banana flowers mixture, one side Selaginella tamariscina, radix glycyrrhizae, banana
The extract of flower mixture, due to the mixing of three Plant Extracts so that preferable coordinative role is played between beneficiating ingredient,
The chafing phenomenon triggered especially for haze weather has preferable anti-inflammatory fungistatic effect；On the other hand adopted in the present invention
With the microcapsule structure of uniqueness, wherein, using chitosan and ultrabranching polyamide compound, Arabic gum mixture as wall material knot
In structure, chitosan and ultrabranching polyamide compound, it is connected between chitosan and ultrabranching polyamide by dodecanedioic acid,
It is in wall material structure, and chitosan can form the first wall material with Arabic gum, and spherical ultrabranching polyamide can form the second wall
Material, the second wall material are closely surrounded in the outside of the first wall material, and this unique double-decker, the applicant is found surprisingly that, right
There is extraordinary moistening effect in skin, while whole anti-inflammatory bacteria inhibiting composition system can be stablized, can resistance to height
Temperature, without destroying anti-inflammatory bacteria inhibiting composition, thus, there is provided the beneficial effect of application itself.
Spikemoss extract
In the present invention, the spikemoss extract is purchased from the Hao Bo bio tech ltd of Shanghai hundred.
Honegsukle flower P.E
The commercially available acquisition of Honegsukle flower P.E in the present invention, can also make by oneself to obtain.
In a preferred embodiment, the preparation method of described Honegsukle flower P.E is：
Honeysuckle is cleaned, soaks 3h with the ethanol that mass fraction is 50%, then boils 1h with the decocting of 4 times of weight, will
The aqueous solution vacuum drying decocted out, is produced.In the present invention, it is limited that the Honegsukle flower P.E is purchased from Xi'an Chang Yue biotechnologies
Company.
Herba Solidaginis extract
In the present invention, the Herba Solidaginis extract is purchased from Xi'an Chang Yue bio tech ltd.
The extract of iris, dandelion mixture
In a preferred embodiment, the iris, the preparation method of extract of dandelion mixture are：
Iris, dandelion are weighed, and is crushed after iris, dandelion are mixed, 15g raw materials is obtained, adds
100g mass fractions are 30% ethanol solution, while 0.01g fullerene activity liquid is added into ethanol solution, at 50 DEG C, are surpassed
Sound 30min, after concentrating the filtrate to no ethanol, obtain iris, the extract of dandelion mixture.
As a kind of preferable technical scheme of the present invention, in the iris, dandelion mixture, iris, dandelion
Between weight ratio be：(1~8)：50.
Green-tea extract
The commercially available acquisition of green-tea extract in the present invention, can also make by oneself to obtain.
In a preferred embodiment, the preparation method of described green-tea extract is：
Stem tea is ground, and is 1 according to each solid-liquid ratio for adding stem tea and 75% volume fraction ethanol:10(g:ML)
Amount twice, each 24h, is then filtered with the extraction of 75% ethanol cold soaking, is merged extract solution, concentration, is redissolved with 1,3 butanediol to phase
Concentration is answered, obtains green-tea extract.
Adlay extract
In the present invention, the adlay extract is purchased from Xi'an Yuan Sen bio tech ltd.
Astragalus Root P.E
The commercially available acquisition of Astragalus Root P.E in the present invention, can also make by oneself to obtain.
In a preferred embodiment, the preparation method of described Astragalus Root P.E is：
The Radix Astragali is cleaned, grinds, add the ether of 10 times of weight, flowed back 1.5h, filtering, and 10 times of weight are added in the dregs of a decoction
Methanol, flow back 1h, filtering, residue is dissolved with water, filter, collect the aqueous solution, the aqueous solution is dried in vacuo, produced.This hair
In bright, the Astragalus Root P.E is purchased from Shaanxi Zhong Xin Bioisystech Co., Ltd.
Lotus Leafextract
In the present invention, the Lotus Leafextract is purchased from Shaanxi Zhong Xin Bioisystech Co., Ltd.
Bilberry fruit P.E
In the present invention, the Bilberry fruit P.E is purchased from Shaanxi Zhong Xin Bioisystech Co., Ltd.
Alpha-arbutin
In the present invention, the alpha-arbutin is purchased from Shanghai Li Sheng Chemical Companies.Meanwhile also created with moisturizing, more,
The effect such as sterilization and collaboration anti-inflammatory.
Cocamidopropyl propyl amide pg dimonium chloride phosphate
In the present invention, the cocamidopropyl propyl amide pg dimonium chloride phosphate is purchased from the limited public affairs of Yantai east chemistry
Department.
Seabuckthorn Oil
In the present invention, the Seabuckthorn Oil is purchased from Mei Ji international corporation.
Fullerene activity liquid
In the present invention, the fullerene activity liquid is purchased from Suzhou great virtue carbon nanosecond science and technology Co., Ltd.
As a kind of preferable technical scheme of the present invention, the anti-inflammatory bacteria inhibiting composition is the preparation of following form：Creme,
Granule, ointment, foaming agent, lotion, emplastrum, tablet, emulsion.
The second aspect of the invention provides a kind of preparation method of anti-inflammatory bacteria inhibiting composition, including at least following steps：
(1) deionized water, chrysanthemum extract, xylitol, cholesterine, bisabolol, ceramide are mixed, at 40 DEG C
After stirring, sunflower seed oil is added, keeping temperature continues after stirring 30min, obtains the first product；
(2) Honegsukle flower P.E, Herba Solidaginis extract, iris, the extract of dandelion mixture, green tea are extracted
Thing, adlay extract, Astragalus Root P.E, Lotus Leafextract, Bilberry fruit P.E, alpha-arbutin, cocamidopropyl propyl amide PG- dimethyl
Ammonium chloride phosphate, Seabuckthorn Oil mix 30min at room temperature；Add the extraction of Selaginella tamariscina, radix glycyrrhizae, banana flowers mixture
Thing, spikemoss extract, fullerene activity liquid stir 20min at 60 DEG C, are cooled to room temperature and obtain the second product；
(3) the second product is all instilled in the first product, deposits 24h at -10 DEG C, obtain anti-inflammatory bacteria inhibiting composition.
The third aspect of the invention provides application of the anti-inflammatory bacteria inhibiting composition in skin conditioning agent field.
Embodiment 1：Embodiment 1 provides a kind of anti-inflammatory bacteria inhibiting composition, and in parts by weight, its raw material at least wraps
Include：30~60 parts of chrysanthemum extract, 10~20 parts of xylitol, 15~20 parts of cholesterine, 10~30 parts of bisabolol, ceramide
5~15 parts, 10~30 parts of sunflower seed oil.
Embodiment 2：Embodiment 2 is identical with embodiment 1, and difference is, the anti-inflammatory bacteria inhibiting composition, with weight
Part meter is measured, its raw material comprises at least：40~50 parts of chrysanthemum extract, 15~20 parts of xylitol, 15~20 parts of cholesterine, opopanax
20~30 parts of alcohol, 0~15 part of Cer EOS, 20~30 parts of sunflower seed oil.
Embodiment 3：Embodiment 3 is identical with embodiment 1 and embodiment 2, and difference is, its raw material also wraps
Include：Selaginella tamariscina, radix glycyrrhizae, 10 parts of 8 parts of 40 parts of extract microcapsules, spikemoss extract, the Honegsukle flower P.E of banana flowers mixture, one
Branch 15 parts of day lily extract, iris, dandelion mixture 4 parts of 5 parts of 12 parts of extract, green-tea extract, adlay extract,
3 parts of Astragalus Root P.E, 3 parts of Lotus Leafextract, 3 parts of Bilberry fruit P.E, 2 parts of alpha-arbutin, cocamidopropyl propyl amide PG- dimethyl chlorides
Change 7 parts of ammonium phosphate, 2 parts of Seabuckthorn Oil, 0.01 part of fullerene activity liquid.
Embodiment 4：Embodiment 4 is identical with embodiment 3, and difference is, the Selaginella tamariscina, radix glycyrrhizae, banana flowers are mixed
The extracting method of the extract microcapsules of compound is：
After weighing Selaginella tamariscina, radix glycyrrhizae, banana flowers mixing, crushed, obtain 22g raw materials, adding 200g mass fractions is
60% ethanol solution, while 0.01g fullerene activity liquid is added into ethanol solution, at 50 DEG C, ultrasonic 30min, obtain the
One extract；
Weigh 5g cyst materials to be dissolved in 40g distilled water, treat that cyst material all dissolves, and add 2g the at room temperature
One extract, stirs, ultrasonic 30min, makes it well mixed, in 175 DEG C of inlet temperature, feed rate 3mL/min, nozzle
It is spray-dried under the conditions of head diameter 0.7mm and nozzle cleaning 2 times/min, obtains Selaginella tamariscina, radix glycyrrhizae, banana flowers mixture and carry
Take thing microcapsules；
The cyst material is：Chitosan and ultrabranching polyamide compound, the mixture of Arabic gum；Chitosan is with surpassing
Weight ratio between branched polyamide compound, Arabic gum is 1：1.
Embodiment 5：Embodiment 5 is identical with embodiment 4, and difference is, the Selaginella tamariscina, radix glycyrrhizae, banana flowers are mixed
In compound, the weight ratio between Selaginella tamariscina, radix glycyrrhizae, banana flowers is：100：(10~30)：(3~7).
Embodiment 6：Embodiment 6 is identical with embodiment 3, and difference is, the iris, dandelion mixture
The preparation method of extract be：
Iris, dandelion are weighed, and is crushed after iris, dandelion are mixed, 15g raw materials is obtained, adds
100g mass fractions are 30% ethanol solution, while 0.01g fullerene activity liquid is added into ethanol solution, at 50 DEG C, are surpassed
Sound 30min, after concentrating the filtrate to no ethanol, obtain iris, the extract of dandelion mixture.
Embodiment 7：Embodiment 7 is identical with embodiment 6, and difference is, the iris, dandelion mixture
In, the weight ratio between iris, dandelion is：(1~8)：50.
Embodiment 8：Embodiment 8 is identical with embodiment 1~7, and difference is, the anti-inflammatory bacteria inhibiting composition is
The preparation of following form：Creme, granule, ointment, foaming agent, lotion, emplastrum, tablet, emulsion.
Embodiment 9：Embodiment 9 be embodiment 3 preparation method, the preparation side of the anti-inflammatory bacteria inhibiting composition
Method, including at least following steps：
(1) deionized water, chrysanthemum extract, xylitol, cholesterine, bisabolol, ceramide are mixed, at 40 DEG C
After stirring, sunflower seed oil is added, keeping temperature continues after stirring 30min, obtains the first product；
(2) Honegsukle flower P.E, Herba Solidaginis extract, iris, the extract of dandelion mixture, green tea are extracted
Thing, adlay extract, Astragalus Root P.E, Lotus Leafextract, Bilberry fruit P.E, alpha-arbutin, cocamidopropyl propyl amide PG- dimethyl
Ammonium chloride phosphate, Seabuckthorn Oil mix 30min at room temperature；Add the extraction of Selaginella tamariscina, radix glycyrrhizae, banana flowers mixture
Thing, spikemoss extract, fullerene activity liquid stir 20min at 60 DEG C, are cooled to room temperature and obtain the second product；
(3) the second product is all instilled in the first product, deposits 24h at -10 DEG C, obtain anti-inflammatory bacteria inhibiting composition.
Embodiment 10：Embodiment 10 is that the anti-inflammatory bacteria inhibiting composition described in embodiment 1~7 is led in skin conditioning agent
Application in domain.
The present invention is specifically described below by embodiment.It is necessarily pointed out that following examples are only used
In the invention will be further described, it is impossible to be interpreted as limiting the scope of the invention, professional and technical personnel in the field
Some the nonessential modifications and adaptations made according to the content of the invention described above, still fall within protection scope of the present invention.
In addition, if without other explanations, raw materials used is all commercially available.
Embodiment
Embodiment 1
The present embodiment 1 provides a kind of anti-inflammatory bacteria inhibiting composition, and in parts by weight, its raw material includes：Chrysanthemum extract 30
Part, 10 parts of xylitol, 15 parts of cholesterine, 10 parts of bisabolol, 5 parts of ceramide, 10 parts of sunflower seed oil.
The chrysanthemum extract is purchased from Shanghai Man Run Chemical Industry Science Co., Ltd；
The xylitol is purchased from Zhejiang Huakang Pharmaceutical Co., Ltd；
The cholesterine is purchased from the conspicuous Industrial Co., Ltd. of sea chart；
The bisabolol is purchased from the joyful beauty bio tech ltd in Wuhan；
It is refined to cosmetics Co., Ltd that the sunflower seed oil is purchased from Guangzhou；
The preparation method of the anti-inflammatory bacteria inhibiting composition, including at least following steps：
Deionized water, chrysanthemum extract, xylitol, cholesterine, bisabolol, ceramide are mixed, stirred at 40 DEG C
After mixing uniformly, sunflower seed oil is added, keeping temperature continues after stirring 30min, obtains the anti-inflammatory bacteria inhibiting composition.
Embodiment 2
The present embodiment 2 provides a kind of anti-inflammatory bacteria inhibiting composition, and in parts by weight, its raw material includes：Chrysanthemum extract 60
Part, 20 parts of xylitol, 20 parts of cholesterine, 30 parts of bisabolol, 5 parts of Cer EOS, 30 parts of sunflower seed oil.
The chrysanthemum extract is purchased from Shanghai Man Run Chemical Industry Science Co., Ltd；
The xylitol is purchased from Zhejiang Huakang Pharmaceutical Co., Ltd；
The cholesterine is purchased from the conspicuous Industrial Co., Ltd. of sea chart；
The bisabolol is purchased from the joyful beauty bio tech ltd in Wuhan；
It is refined to cosmetics Co., Ltd that the sunflower seed oil is purchased from Guangzhou；
The preparation method of the anti-inflammatory bacteria inhibiting composition, including at least following steps：
Deionized water, chrysanthemum extract, xylitol, cholesterine, bisabolol, ceramide are mixed, stirred at 40 DEG C
After mixing uniformly, sunflower seed oil is added, keeping temperature continues after stirring 30min, obtains the anti-inflammatory bacteria inhibiting composition.
Embodiment 3
The present embodiment 3 provides a kind of anti-inflammatory bacteria inhibiting composition, and in parts by weight, its raw material includes：Chrysanthemum extract 45
Part, 18 parts of xylitol, 16 parts of cholesterine, 25 parts of bisabolol, 3 parts of Cer EOS, 25 parts of sunflower seed oil.
The chrysanthemum extract is purchased from Shanghai Man Run Chemical Industry Science Co., Ltd；
The xylitol is purchased from Zhejiang Huakang Pharmaceutical Co., Ltd；
The cholesterine is purchased from the conspicuous Industrial Co., Ltd. of sea chart；
The bisabolol is purchased from the joyful beauty bio tech ltd in Wuhan；
It is refined to cosmetics Co., Ltd that the sunflower seed oil is purchased from Guangzhou；
The preparation method of the anti-inflammatory bacteria inhibiting composition, including at least following steps：
Deionized water, chrysanthemum extract, xylitol, cholesterine, bisabolol, ceramide are mixed, stirred at 40 DEG C
After mixing uniformly, sunflower seed oil is added, keeping temperature continues after stirring 30min, obtains the anti-inflammatory bacteria inhibiting composition.
Embodiment 4
The present embodiment 4 provides a kind of anti-inflammatory bacteria inhibiting composition, and in parts by weight, its raw material includes：Chrysanthemum extract 40
Part, 15 parts of xylitol, 15 parts of cholesterine, 20 parts of bisabolol, 0 part of Cer EOS, 20 parts of sunflower seed oil.
The chrysanthemum extract is purchased from Shanghai Man Run Chemical Industry Science Co., Ltd；
The xylitol is purchased from Zhejiang Huakang Pharmaceutical Co., Ltd；
The cholesterine is purchased from the conspicuous Industrial Co., Ltd. of sea chart；
The bisabolol is purchased from the joyful beauty bio tech ltd in Wuhan；
It is refined to cosmetics Co., Ltd that the sunflower seed oil is purchased from Guangzhou；
The preparation method of the anti-inflammatory bacteria inhibiting composition, including at least following steps：
Deionized water, chrysanthemum extract, xylitol, cholesterine, bisabolol, ceramide are mixed, stirred at 40 DEG C
After mixing uniformly, sunflower seed oil is added, keeping temperature continues after stirring 30min, obtains the anti-inflammatory bacteria inhibiting composition.
Embodiment 5
The present embodiment 5 provides a kind of anti-inflammatory bacteria inhibiting composition, and in parts by weight, its raw material includes：Chrysanthemum extract 50
Part, 20 parts of xylitol, 20 parts of cholesterine, 30 parts of bisabolol, 5 parts of Cer EOS, 30 parts of sunflower seed oil.
The chrysanthemum extract is purchased from Shanghai Man Run Chemical Industry Science Co., Ltd；
The xylitol is purchased from Zhejiang Huakang Pharmaceutical Co., Ltd；
The cholesterine is purchased from the conspicuous Industrial Co., Ltd. of sea chart；
The bisabolol is purchased from the joyful beauty bio tech ltd in Wuhan；
It is refined to cosmetics Co., Ltd that the sunflower seed oil is purchased from Guangzhou；
The preparation method of the anti-inflammatory bacteria inhibiting composition, including at least following steps：
Deionized water, chrysanthemum extract, xylitol, cholesterine, bisabolol, ceramide are mixed, stirred at 40 DEG C
After mixing uniformly, sunflower seed oil is added, keeping temperature continues after stirring 30min, obtains the anti-inflammatory bacteria inhibiting composition.
Embodiment 6
The present embodiment 6 provides a kind of anti-inflammatory bacteria inhibiting composition, and in parts by weight, its raw material includes：Chrysanthemum extract 45
Part, 18 parts of xylitol, 16 parts of cholesterine, 25 parts of bisabolol, 3 parts of Cer EOS, 25 parts of sunflower seed oil, Selaginella tamariscina, radix glycyrrhizae,
10 parts of 8 parts of 40 parts of extract microcapsules, spikemoss extract, Honegsukle flower P.E, the Herba Solidaginis extract of banana flowers mixture
15 parts, iris, 4 parts of 5 parts of 12 parts of extract, green-tea extract, adlay extract, the Astragalus Root P.E 3 of dandelion mixture
Part, 3 parts of Lotus Leafextract, 3 parts of Bilberry fruit P.E, 2 parts of alpha-arbutin, cocamidopropyl propyl amide pg dimonium chloride phosphate 7
Part, 2 parts of Seabuckthorn Oil, 0.01 part of fullerene activity liquid.
The Selaginella tamariscina, radix glycyrrhizae, the extracting method of extract microcapsules of banana flowers mixture are：
After weighing Selaginella tamariscina, radix glycyrrhizae, banana flowers mixing, crushed, obtain 22g raw materials, adding 200g mass fractions is
60% ethanol solution, while 0.01g fullerene activity liquid is added into ethanol solution, at 50 DEG C, ultrasonic 30min, obtain the
One extract；
In the Selaginella tamariscina, radix glycyrrhizae, banana flowers mixture, the weight ratio between Selaginella tamariscina, radix glycyrrhizae, banana flowers is：100：15：5；
Weigh 5g cyst materials to be dissolved in 40g distilled water, treat that cyst material all dissolves, and add 2g the at room temperature
One extract, stirs, ultrasonic 30min, makes it well mixed, in 175 DEG C of inlet temperature, feed rate 3mL/min, nozzle
It is spray-dried under the conditions of head diameter 0.7mm and nozzle cleaning 2 times/min, obtains Selaginella tamariscina, radix glycyrrhizae, banana flowers mixture and carry
Take thing microcapsules；
The cyst material is：Chitosan and ultrabranching polyamide compound, the mixture of Arabic gum；Chitosan is with surpassing
Weight ratio between branched polyamide compound, Arabic gum is 1：1；
The preparation method of the chitosan and ultrabranching polyamide compound, including at least following steps：
5g dodecanedioic acid is dissolved in 20mL dimethyl sulfoxide (DMSO)s and obtains dodecanedioic acid solution；15g shell is gathered
Sugar is dissolved in 50mL dimethyl sulfoxide (DMSO)s and obtains chitosan solution；15g ultrabranching polyamide is dissolved in 50mL dimethyl Asia
Ultrabranching polyamide solution is obtained in sulfone；Then dodecanedioic acid solution is added in reactor, stirred, keeping temperature 50
DEG C, chitosan solution is then added, is cooled after reacting 3h, you can obtain dodecanedioic acid modification of chitosan；Then to 12
Ultrabranching polyamide solution is added in docosandioic acid modification of chitosan, at 60 DEG C, continues to cool after reacting 2h, washs, dries, i.e.,
It can obtain chitosan and ultrabranching polyamide compound.
The iris, the preparation method of extract of dandelion mixture are：
Iris, dandelion are weighed, and is crushed after iris, dandelion are mixed, 15g raw materials is obtained, adds
100g mass fractions are 30% ethanol solution, while 0.01g fullerene activity liquid is added into ethanol solution, at 50 DEG C, are surpassed
Sound 30min, after concentrating the filtrate to no ethanol, obtain iris, the extract of dandelion mixture.
In the iris, dandelion mixture, the weight ratio between iris, dandelion is：7：50.
The chrysanthemum extract is purchased from Shanghai Man Run Chemical Industry Science Co., Ltd；
The xylitol is purchased from Zhejiang Huakang Pharmaceutical Co., Ltd；
The cholesterine is purchased from the conspicuous Industrial Co., Ltd. of sea chart；
The bisabolol is purchased from the joyful beauty bio tech ltd in Wuhan；
It is refined to cosmetics Co., Ltd that the sunflower seed oil is purchased from Guangzhou；
The spikemoss extract is purchased from the Hao Bo bio tech ltd of Shanghai hundred；
The Honegsukle flower P.E is purchased from Xi'an Chang Yue bio tech ltd；
The Herba Solidaginis extract is purchased from Xi'an Chang Yue bio tech ltd；
The adlay extract is purchased from Xi'an Yuan Sen bio tech ltd；
The Astragalus Root P.E is purchased from Shaanxi Zhong Xin Bioisystech Co., Ltd；
The Lotus Leafextract is purchased from Shaanxi Zhong Xin Bioisystech Co., Ltd；
The Bilberry fruit P.E is purchased from Shaanxi Zhong Xin Bioisystech Co., Ltd；
The alpha-arbutin is purchased from Shanghai Li Sheng Chemical Companies；
The cocamidopropyl propyl amide pg dimonium chloride phosphate is purchased from Yantai east Chemical Co., Ltd.；
The Seabuckthorn Oil is purchased from Mei Ji international corporation；
The fullerene activity liquid is purchased from Suzhou great virtue carbon nanosecond science and technology Co., Ltd.
The preparation method of anti-inflammatory bacteria inhibiting composition, including at least following steps：
(1) deionized water, chrysanthemum extract, xylitol, cholesterine, bisabolol, ceramide are mixed, at 40 DEG C
After stirring, sunflower seed oil is added, keeping temperature continues after stirring 30min, obtains the first product；
(2) Honegsukle flower P.E, Herba Solidaginis extract, iris, the extract of dandelion mixture, green tea are extracted
Thing, adlay extract, Astragalus Root P.E, Lotus Leafextract, Bilberry fruit P.E, alpha-arbutin, cocamidopropyl propyl amide PG- dimethyl
Ammonium chloride phosphate, Seabuckthorn Oil mix 30min at room temperature；Add the extraction of Selaginella tamariscina, radix glycyrrhizae, banana flowers mixture
Thing, spikemoss extract, fullerene activity liquid stir 20min at 60 DEG C, are cooled to room temperature and obtain the second product；
(3) the second product is all instilled in the first product, deposits 24h at -10 DEG C, obtain anti-inflammatory bacteria inhibiting composition.
Comparative example 1
With embodiment 6, difference is comparative example 1, not including Selaginella tamariscina, radix glycyrrhizae, banana flowers mixture the micro- glue of extract
Capsule.
Comparative example 2
With embodiment 6, difference is comparative example 2, by Selaginella tamariscina, radix glycyrrhizae, banana flowers mixture extract microcapsules more
Selaginella tamariscina, radix glycyrrhizae, the extract of banana flowers mixture are changed into, without being prepared into microcapsules.Wherein, Selaginella tamariscina, radix glycyrrhizae, banana flowers mixing
The preparation process of the extract of thing is the same as embodiment 6.
Comparative example 3
With embodiment 6, difference is comparative example 3, by Selaginella tamariscina, radix glycyrrhizae, banana flowers mixture extract microcapsules more
Change spikemoss extract microcapsules into.Wherein, the preparation process of spikemoss extract microcapsules does not include radix glycyrrhizae simply with embodiment 6
And banana flowers.
Comparative example 4
With embodiment 6, difference is comparative example 4, by Selaginella tamariscina, radix glycyrrhizae, banana flowers mixture extract microcapsules more
Change licorice microcapsules into.Wherein, the preparation process of licorice microcapsules does not include Selaginella tamariscina simply with embodiment 6
And banana flowers.
Comparative example 5
With embodiment 6, difference is comparative example 5, by Selaginella tamariscina, radix glycyrrhizae, banana flowers mixture extract microcapsules more
Change banana flowers extract microcapsules into.Wherein, the preparation process of banana flowers extract microcapsules does not include simply with embodiment 6
Selaginella tamariscina and radix glycyrrhizae.
Comparative example 6
With embodiment 6, difference is comparative example 6, by Selaginella tamariscina, radix glycyrrhizae, banana flowers mixture extract microcapsules in
Cyst wall be replaced with Arabic gum.
Comparative example 7
With embodiment 6, difference is comparative example 7, by Selaginella tamariscina, radix glycyrrhizae, banana flowers mixture extract microcapsules in
Cyst wall be replaced with chitosan.
Comparative example 8
With embodiment 6, difference is comparative example 8, by Selaginella tamariscina, radix glycyrrhizae, banana flowers mixture extract microcapsules in
Cyst wall be replaced with chitosan, Arabic gum, and the weight ratio between chitosan, Arabic gum is 1：1.
Comparative example 9
With embodiment 6, difference is comparative example 9, by Selaginella tamariscina, radix glycyrrhizae, banana flowers mixture extract microcapsules in
Cyst wall be replaced with ultrabranching polyamide.
Comparative example 10
With embodiment 6, difference is comparative example 10, by Selaginella tamariscina, radix glycyrrhizae, banana flowers mixture extract microcapsules in
Cyst wall be replaced with chitosan and ultrabranching polyamide compound.
Comparative example 11
Comparative example 11 is with embodiment 6, difference is, difference is, Selaginella tamariscina, radix glycyrrhizae, banana flowers mixture are carried
During the synthesis for taking thing microcapsules, fullerene activity liquid is added without.
Performance test
1st, bacteriostasis property is evaluated
Due to air pollutions such as hazes so that in air, Escherichia coli, staphylococcus aureus, propionibacterium acnes connect
Tactile skin easily cause skin acne, it is sensitive phenomena such as.
Bacteriostasis property evaluation reference Chinese Patent Application No. in the application：CN201510395607.9.
Odontothrips loti：Corresponding culture medium, 121 DEG C of high pressure steam sterilization, 20min are configured according to different strains testeds.Make
Solid medium flat board, each culture dish about pours into 20mL culture mediums, and after culture medium solidifying, 100 μ L bacterium solutions are taken with liquid-transfering gun
(bacteria suspension for having been subjected to Maxwell turbidimetry for Determination concentration) is instilled in culture dish, and using spread plate, bacteria suspension is uniformly applied
It is distributed on solid medium.Media surface directly vertically put Oxford cup (internal diameter 6mm, external diameter 8mm, high 10mm circle
Tubule), gently pressurize, it is contacted tight with culture medium.Each culture dish places three Oxford cups.Add in each Oxford cup
Enter 200 μ L testing samples, the culture dish of bacterium is gently placed in bacteriological incubator or so 37 DEG C of cultures, 16 hours.
Note：Antibacterial circle diameter >=30mm has been judged to very good bacteriostasis, antibacterial circle diameter 20mm for extremely sensitive " ++++"
≤ bacteriostatic diameter<30mm has been judged to bacteriostasis, 15mm≤bacteriostatic diameter for extremely sensitive " +++ "<20mm is Gao Min " ++ "；10mm
≤ bacteriostatic diameter<15mm quick "+" in being；Bacteriostatic diameter<10mm is invalid, is judged to no bacteriostasis.Wherein, the bigger suppression of inhibition zone
Bacterium effect is better.
The fungistatic effect evaluation table of table 1
| Embodiment | The antibacterial grade of Escherichia coli | The antibacterial grade of staphylococcus aureus | The antibacterial grade of propionibacterium acnes |
| Embodiment 1 | ++ | ++ | ++ |
| Embodiment 2 | ++ | +++ | +++ |
| Embodiment 3 | +++ | +++ | ++ |
| Embodiment 4 | ++ | +++ | ++ |
| Embodiment 5 | +++ | +++ | +++ |
| Embodiment 6 | ++++ | ++++ | ++++ |
| Comparative example 1 | +++ | ++ | ++ |
| Comparative example 2 | +++ | +++ | ++ |
| Comparative example 3 | ++ | ++ | +++ |
| Comparative example 4 | +++ | ++ | ++ |
| Comparative example 5 | +++ | ++ | ++ |
| Comparative example 6 | +++ | +++ | ++ |
| Comparative example 7 | +++ | +++ | ++ |
| Comparative example 8 | +++ | +++ | ++ |
| Comparative example 9 | +++ | +++ | ++ |
| Comparative example 10 | +++ | +++ | +++ |
| Comparative example 11 | ++++ | +++ | +++ |
The product of the present invention is for the Escherichia coli, staphylococcus aureus, acne third that occur in the air pollutions such as haze
Acidfast bacilli has preferable fungistatic effect.
2nd, moisture retention effect assessment
Test philosophy：According to composition moisture absorption, the difference of performance of keeping humidity, active force of the different moisturizing agent molecules to hydrone
Difference, it is different with the ability of moisture is kept to absorb moisture.Oil content has sealing process to moisture, can prevent scattering and disappearing for moisture.Moisture absorption
Active force is big, strong to water molecules power, absorbs and keeps that the amount of moisture is also bigger, closure is good, moisture loss
Also it is few.The biomaterial of cuticula, epidermis etc. is imitated using adhesive tape, cosmetics are coated with adhesive tape, simulates practical application situation.
Sample is placed under conditions of constant humidity after certain time, is weighed and is put front and rear of poor quality, obtains the loss of sample size, can calculate
The effect of moisturizing ingredient moisturizing.It is shown in Table 5.
Moisturizing rate calculation formula：Moisturizing rate=(M2–M0)/(M1–M0) × 100%
In formula：
M0：Hollow plate quality/g；
M1：Glass sheet quality/g after sample-adding；
M2：Quality/g after some hours is placed in drier；
Test its relative humidity be 60% when 4h and 8h in moisturizing rate；
The moisture retention test result of table 2
| Embodiment | 4h | 8h |
| Embodiment 1 | 44% | 30% |
| Embodiment 2 | 45% | 32% |
| Embodiment 3 | 49% | 35% |
| Embodiment 4 | 51% | 38% |
| Embodiment 5 | 55% | 38% |
| Embodiment 6 | 93% | 85% |
| Comparative example 1 | 60% | 42% |
| Comparative example 2 | 65% | 40% |
| Comparative example 3 | 55% | 43% |
| Comparative example 4 | 58% | 45% |
| Comparative example 5 | 70% | 38% |
| Comparative example 6 | 75% | 59% |
| Comparative example 7 | 68% | 50% |
| Comparative example 8 | 80% | 61% |
| Comparative example 9 | 78% | 55% |
| Comparative example 10 | 84% | 71% |
| Comparative example 11 | 81% | 68% |
3rd, physical and chemical index is tested
Sensory testing：The character of product is visually observed, sees if there is exception；
Resistance to Thermal test：Sample is put into 24h in the electro-heating standing-temperature cultivator of (40 ± 1) DEG C, seen whether after recovering room temperature
There is phenomena such as thinning, discoloration, layering and firmness change, with the heat resistance of judgement sample；
Low temperature resistant test：Sample is put into 24h in the refrigerator of (- 5~-10) DEG C ± 1 DEG C, seen whether after recovering room temperature
Phenomena such as thinning, discoloration, layering and firmness change, with the cold tolerance of judgement sample；
Centrifugal test：Sample is placed in a centrifuge, with (2000~4000) r/min speed test 30min, observes sample
The separation of product, layering situation.
The physical and chemical index result of table 3
| Embodiment | Sensory testing | Resistance to Thermal test | Low temperature resistant test | Centrifugal test |
| Embodiment 1 | It is without exception | It is stable | It is stable | It is stable |
| Embodiment 2 | It is without exception | It is stable | It is stable | It is stable |
| Embodiment 3 | It is without exception | It is stable | It is stable | It is stable |
| Embodiment 4 | It is without exception | It is stable | It is stable | It is stable |
| Embodiment 5 | It is without exception | It is stable | It is stable | It is stable |
| Embodiment 6 | It is without exception | It is stable | It is stable | It is stable |
| Comparative example 1 | It is without exception | It is unstable | It is unstable | It is unstable |
| Comparative example 2 | It is without exception | It is unstable | It is stable | It is stable |
| Comparative example 3 | It is without exception | It is stable | It is stable | It is stable |
| Comparative example 4 | It is without exception | It is stable | It is stable | It is stable |
| Comparative example 5 | It is without exception | It is stable | It is stable | It is stable |
| Comparative example 6 | It is without exception | It is unstable | It is stable | It is stable |
| Comparative example 7 | It is without exception | It is stable | It is stable | It is unstable |
| Comparative example 8 | It is without exception | It is unstable | It is stable | It is stable |
| Comparative example 9 | It is without exception | It is unstable | It is unstable | It is unstable |
| Comparative example 10 | It is without exception | It is unstable | It is unstable | It is unstable |
| Comparative example 1 | It is without exception | It is stable | It is stable | It is stable |
Choose 200 volunteers, women, the age in 20 one full year of life between 50 one full year of life, wherein, 200 entitled live in for a long time
The heavier city of haze, the face of volunteer is because air pollutions such as the pressure of life, haze etc. cause face to dry, play acne.
Volunteer respectively highlights composition once using whitening sooner or later daily, each dosage 5ml, face is uniformly applied to, persistently using 1
The moon, observe the change situation of skin of face.As a result show, 100% volunteer's skin of face has obvious cure to imitate to playing acne
Fruit；100% volunteer's skin of face moistening effect is obvious.
Foregoing example is merely illustrative, some features of the feature for explaining the disclosure.Appended claim
It is intended to require the scope as wide as possible being contemplated that, and embodiments as presented herein is only according to all possible embodiment
Combination selection embodiment explanation.Therefore, the purpose of applicant is appended claim not by the explanation present invention
Feature example selectional restriction.And the progress in science and technology will not formed due to the inaccuracy of language performance and not
The possible equivalent or son being presently considered are replaced, and these changes should also be interpreted by appended in the conceived case
Claim covers.
Claims (10)
1. a kind of anti-inflammatory bacteria inhibiting composition, it is characterised in that in parts by weight, its raw material comprises at least：Chrysanthemum extract 30~
60 parts, 10~20 parts of xylitol, 15~20 parts of cholesterine, 10~30 parts of bisabolol, 5~15 parts of ceramide, sunflower seed
10~30 parts of oil.
2. anti-inflammatory bacteria inhibiting composition as claimed in claim 1, it is characterised in that in parts by weight, its raw material comprises at least：Chrysanthemum
40~50 parts of flower extract, 15~20 parts of xylitol, 15~20 parts of cholesterine, 20~30 parts of bisabolol, Cer EOS 0~
15 parts, 20~30 parts of sunflower seed oil.
3. the anti-inflammatory bacteria inhibiting composition as described in any one of claim 1 or 2, it is characterised in that the anti-inflammatory bacteria inhibiting composition,
In parts by weight, its raw material also includes：Selaginella tamariscina, radix glycyrrhizae, 40 parts of extract microcapsules, the spikemoss extract 8 of banana flowers mixture
Part, 12 parts of extract, the green tea of 10 parts of Honegsukle flower P.E, 15 parts of Herba Solidaginis extract, iris, dandelion mixture carry
Take 5 parts of thing, 4 parts of adlay extract, 3 parts of Astragalus Root P.E, 3 parts of Lotus Leafextract, 3 parts of Bilberry fruit P.E, 2 parts of alpha-arbutin,
7 parts of cocamidopropyl propyl amide pg dimonium chloride phosphate, 2 parts of Seabuckthorn Oil, 0.01 part of fullerene activity liquid.
4. anti-inflammatory bacteria inhibiting composition as claimed in claim 3, it is characterised in that the Selaginella tamariscina, radix glycyrrhizae, banana flowers mixture
The extracting method of extract microcapsules is：
After weighing Selaginella tamariscina, radix glycyrrhizae, banana flowers mixing, crushed, obtain 22g raw materials, it is 60% second to add 200g mass fractions
Alcoholic solution, while 0.01g fullerene activity liquid is added into ethanol solution, at 50 DEG C, ultrasonic 30min, obtain the first extraction
Thing；
Weigh 5g cyst materials to be dissolved in 40g distilled water, treat that cyst material all dissolves, and add 2g first at room temperature and carry
Thing is taken, is stirred, ultrasonic 30min, makes it well mixed, it is straight in 175 DEG C of inlet temperature, feed rate 3mL/min, nozzle head
It is spray-dried under the conditions of 2 times/min of footpath 0.7mm and nozzle cleaning, obtains Selaginella tamariscina, radix glycyrrhizae, the extract of banana flowers mixture
Microcapsules；
The cyst material is：Chitosan and ultrabranching polyamide compound, the mixture of Arabic gum；Chitosan with it is hyperbranched
Weight ratio between polyamide compound, Arabic gum is 1：1.
5. anti-inflammatory bacteria inhibiting composition as claimed in claim 4, it is characterised in that the Selaginella tamariscina, radix glycyrrhizae, banana flowers mixture
In, the weight ratio between Selaginella tamariscina, radix glycyrrhizae, banana flowers is：100：(10~30)：(3~7).
6. anti-inflammatory bacteria inhibiting composition as claimed in claim 3, it is characterised in that the iris, dandelion mixture carry
The preparation method for taking thing is：
Iris, dandelion are weighed, and is crushed after iris, dandelion are mixed, 15g raw materials is obtained, adds 100g matter
Amount fraction is 30% ethanol solution, while 0.01g fullerene activity liquid is added into ethanol solution, at 50 DEG C, ultrasound
30min, after concentrating the filtrate to no ethanol, obtain iris, the extract of dandelion mixture.
7. anti-inflammatory bacteria inhibiting composition as claimed in claim 6, it is characterised in that in the iris, dandelion mixture, butterfly
Weight ratio between phalaenopsis, dandelion is：(1~8)：50.
8. the anti-inflammatory bacteria inhibiting composition as described in claim 1~7, it is characterised in that the anti-inflammatory bacteria inhibiting composition is following
The preparation of form：Creme, granule, ointment, foaming agent, lotion, emplastrum, tablet, emulsion.
9. anti-inflammatory bacteria inhibiting composition as claimed in claim 3, it is characterised in that the preparation side of the anti-inflammatory bacteria inhibiting composition
Method, including at least following steps：
(1) deionized water, chrysanthemum extract, xylitol, cholesterine, bisabolol, ceramide are mixed, stirred at 40 DEG C
After uniformly, sunflower seed oil is added, keeping temperature continues after stirring 30min, obtains the first product；
(2) by Honegsukle flower P.E, Herba Solidaginis extract, iris, the extract of dandelion mixture, green-tea extract,
Adlay extract, Astragalus Root P.E, Lotus Leafextract, Bilberry fruit P.E, alpha-arbutin, cocamidopropyl propyl amide PG- dimethyl chlorides
Change ammonium phosphate, Seabuckthorn Oil mixes 30min at room temperature；Add Selaginella tamariscina, radix glycyrrhizae, banana flowers mixture extract,
Spikemoss extract, fullerene activity liquid stir 20min at 60 DEG C, are cooled to room temperature and obtain the second product；
(3) the second product is all instilled in the first product, deposits 24h at -10 DEG C, obtain anti-inflammatory bacteria inhibiting composition.
10. application of the anti-inflammatory bacteria inhibiting composition in skin conditioning agent field as described in claim 1~7.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108078868A (en) * | 2018-02-01 | 2018-05-29 | 四川艾医生医疗科技有限公司 | A kind of antiallergic composition for skin care item |
| CN111265547A (en) * | 2020-02-26 | 2020-06-12 | 上海紫河生物科技有限公司 | Fullerene and fullerene derivative-containing disinfection spray and preparation method thereof |
| CN113710331A (en) * | 2019-03-12 | 2021-11-26 | 西姆莱斯股份公司 | Antimicrobial mixture |
| CN115569093A (en) * | 2022-09-09 | 2023-01-06 | 安徽亿人安股份有限公司 | A skin care cream with antibacterial effect for infant with dampness eliminating effect, and its preparation method |
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| CN105267396A (en) * | 2015-11-25 | 2016-01-27 | 严瑾 | Antibacterial anti-inflammatory composition as well as preparation method and pharmaceutical preparation thereof |
| CN105496994A (en) * | 2015-12-24 | 2016-04-20 | 苏州药基美研医药科技有限公司 | External preparation for skin |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105267396A (en) * | 2015-11-25 | 2016-01-27 | 严瑾 | Antibacterial anti-inflammatory composition as well as preparation method and pharmaceutical preparation thereof |
| CN105496994A (en) * | 2015-12-24 | 2016-04-20 | 苏州药基美研医药科技有限公司 | External preparation for skin |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108078868A (en) * | 2018-02-01 | 2018-05-29 | 四川艾医生医疗科技有限公司 | A kind of antiallergic composition for skin care item |
| CN108078868B (en) * | 2018-02-01 | 2020-12-25 | 四川艾医生医疗科技有限公司 | Antiallergic composition for skin care products |
| CN113710331A (en) * | 2019-03-12 | 2021-11-26 | 西姆莱斯股份公司 | Antimicrobial mixture |
| CN113710331B (en) * | 2019-03-12 | 2024-03-22 | 西姆莱斯股份公司 | Antimicrobial mixture |
| CN111265547A (en) * | 2020-02-26 | 2020-06-12 | 上海紫河生物科技有限公司 | Fullerene and fullerene derivative-containing disinfection spray and preparation method thereof |
| CN115569093A (en) * | 2022-09-09 | 2023-01-06 | 安徽亿人安股份有限公司 | A skin care cream with antibacterial effect for infant with dampness eliminating effect, and its preparation method |
| CN115569093B (en) * | 2022-09-09 | 2023-10-13 | 安徽亿人安股份有限公司 | Infant dampness-dispelling skin-care cream with antibacterial effect and preparation method thereof |
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Application publication date: 20171124 |