CN108379099A - A kind of skin whitener containing fullerene - Google Patents
A kind of skin whitener containing fullerene Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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Abstract
The invention discloses a kind of skin whiteners containing fullerene, including following raw material：1.0 parts of fuller olefinic carbon 60 .01,13 parts of Herba Blumeae Balsamiferae extract, 2 10 parts of Semen Celosiae extract, 0.5 2 parts of Chinese knotweed's extract, 1 10 parts of interwined dragon conopsea extraction, 5 15 parts of glycerine, 0.5 5 parts of Tween 80,20 0.5 3 parts of ceteareth, 0.1 0.6 parts of dipotassium glycyrrhizinate, 0.02 0.2 parts of EDTA disodiums, 0.01 0.5 parts of citric acid, 80 150 parts of pure water.The Herba Blumeae Balsamiferae extract that the new extracting method of the present invention is prepared, Semen Celosiae extract, Chinese knotweed's extract, interwined dragon conopsea extraction, ingredient are changed with activity, are used in combination with fullerene, and best whitening effect can be reached.
Description
Technical field
The present invention relates to cosmetic technical field more particularly to a kind of skin whiteners containing fullerene.
Background technology
With the development of society and the improvement of people's living standards, requirement of the consumer to daily nursing product be also increasingly
Height requires the effect of to product also increasingly to refine.Because yellow's colour of skin problem, Chinese's generally existing colour of skin are obscure, dim
The problems such as yellow, shortage gloss, easy allergy, pigment deposition.Expert data shows that pigmentation phenomenon accounts for about 80% in women
Ratio, and another item data shows that Chinese women 80% is all Combination skin, and it is maximum that this kind of skin faces that the colour of skin is irregular
Problem, how one of whitening and the most concerned topic of Chinese Consumer's.
The method treated at present is mainly by laser nti-freckle, although freckle effect is quick, patient needs to bear shouting pain
Sense, and easily recur, so not being best therapy for the patient;Also some corrosive medicines or de- can be used
Color ointment is coated with affected part, and sore spot at skin lesion is promoted to fall off;Also useful Chinese medicine passes through enriching yin and nourishing kidney, dispersing stagnated hepatoqi, neutralization qi and blood etc.
It is equipped with systemic therapy.But these methods are not that can cause greatly to injure to skin, and the time of but being decocted medicinal herbs using herbal treatment is long, system
Standby trouble, it is difficult to adhere to, from the ideal effect without reaching nti-freckle, whitening.
Based on this, develop that a whitening effect is notable, and the skin whitener for not injuring skin is urgently to be resolved hurrily.
Invention content
Unresolved existing whitening product effect is not ideal enough, and the present invention provides a kind of skin whitener containing fullerene, reaches fast
Fast whitening and the effect not rebounded.
To reach above-mentioned technical purpose, it is achieved by following technical solution：
A kind of skin whitener containing fullerene, including following raw material：.01-1.0 parts of fuller olefinic carbon 60, Herba Blumeae Balsamiferae extract 1-3
Part, 2-10 parts of Semen Celosiae extract, 0.5-2 parts of Chinese knotweed's extract, 1-10 parts of interwined dragon conopsea extraction, 5-15 parts of glycerine are spat
- 80 0.5-5 parts of temperature, -20 0.5-3 parts of ceteareth, 0.1-0.6 parts of dipotassium glycyrrhizinate, EDTA- disodiums 0.02-
0.2 part, 0.01-0.5 parts of citric acid, 80-150 parts of pure water.
Preferably, the skin whitener, including following raw material：.01-0.5 parts of fuller olefinic carbon 60, Herba Blumeae Balsamiferae extract
1-2 parts, 5-10 parts of Semen Celosiae extract, 1-2 parts of Chinese knotweed's extract, 3-5 parts of interwined dragon conopsea extraction, 10-15 parts of glycerine spits
- 80 0.5-2 parts of temperature, -20 0.5-2 parts of ceteareth, 0.1-0.2 parts of dipotassium glycyrrhizinate, EDTA- disodiums 0.5-
0.1 part, 0.01-0.1 parts of citric acid, 100-120 parts of pure water.
Preferably, the skin whitener, including following raw material：.05 parts of fuller olefinic carbon 60, Herba Blumeae Balsamiferae extract 1.5
Part, 8 parts of Semen Celosiae extract, 1.5 parts of Chinese knotweed's extract, 4 parts of interwined dragon conopsea extraction, 12 parts of glycerine, 1.5 parts of Tween-80,
1.2 parts of ceteareth -20,0.15 part of dipotassium glycyrrhizinate, 0.6 part of EDTA- disodiums, 0.08 part of citric acid, pure water
110 parts.
Preferably, the preparation method of the Herba Blumeae Balsamiferae extract is：
（1）Blumea balsamifera 5KG uses 5-10L 50-70% alcohol refluxs to extract 2 times after crushed, each 3h；
（2）Total medicinal extract is obtained after extracting solution evaporated under reduced pressure, total medicinal extract is scattered in 1-2L water, successively with isometric petroleum ether, second
Acetoacetic ester and extracting n-butyl alcohol extract 3-4 times respectively, and each extraction phase medicinal extract is recovered under reduced pressure to obtain；
（3）Merge petroleum ether and n-butanol fraction to get Herba Blumeae Balsamiferae extract；
Wherein, percentage is percentage by volume.
Preferably, the preparation method of the Semen Celosiae extract is：
（1）The 5KG seed of feather cockscombs are put into the ethyl alcohol of the 70%-80% of its 25-30L, extract 2-3 times under the conditions of 50-60 DEG C, often
Secondary 2 hours, merge extracting solution, filtering, filtrate is concentrated in vacuo through solvent is recovered under reduced pressure into seed of feather cockscomb crude extract；
（2）Gained seed of feather cockscomb crude extract is put into the water of its 10-20L and is dissolved, is 5-6 with diluted alkaline NaHC03 adjustment pH values, on
Processed D101 large pore resin absorption columns are first eluted with 4BV water with 1-1.5BV/h, then water-soluble with 20%, 40% ethyl alcohol successively
Liquid gradient elution, flow velocity are 1-1.5BV/h, collect ethanol eluate, are concentrated under reduced pressure into thick paste；
（3）Step（2）Gained thick paste adds 1-2KG chromatographic grade silica gel to mix thoroughly, and fine powder is ground into after low-temperature vacuum drying, add 8 times amount
Ethyl acetate refluxing extraction 3 times 1 hour every time, collects extracting solution, recycling design, and extracting solution low-temperature vacuum drying obtains powder, adds
Enter ethyl alcohol dissolving, 4-8 DEG C is placed crystallization, and gained is crystallized through being drying to obtain Semen Celosiae extract；
Wherein, percentage is percentage by volume.
Preferably, the preparation method of Chinese knotweed's extract is：
（1）Chinese knotweed's rhizome is shone into dry grinding, 5KG live charcoal female powders are added the hydrochloric acid solution of a concentration of 0.4mol/L of 20-30L, put
Enter and extracted in 60-70 DEG C of water-bath, is taken out after extracting 2h, after suction filtration, obtain filtrate, merging filtrate；
（2）Step（2）Gained merging filtrate with alkali tune PH to 7.0, then press filtrate：95% ethyl alcohol weight ratio is 1: 5-6, by 95%
Ethyl alcohol is added in filtrate, and sealing is placed to complete precipitation；
（3）Finally ethanol precipitation liquid 4-8 DEG C, after centrifuging 15-20min, is outwelled ethyl alcohol above, used through 12000r/min
Absolute ethyl alcohol washs 2-3 times, pellet frozen drying to obtain Chinese knotweed's extract；
Wherein, percentage is percentage by volume.
Preferably, the preparation method of the interwined dragon conopsea extraction is：
（1）Chinese Ladiestresses Root or Herb medicinal material 1KG is weighed, soaked overnight is thinly sliced, and water 4-8L is added, and adds cellulase 1-1.5g, pectase
1-1.5g, 45 DEG C are reacted 2-3 hours, then add 95% ethyl alcohol of 2-4L into extracting solution, and 55 DEG C are flowed back 3 hours, and extracting solution is filtered to obtain
1；
（2）Step（1）Residue obtained plus 8-10L 70-80% ethanols, 55-65 DEG C is flowed back 2 hours, and extracting solution 2 is filtered to obtain；
（3）Merge filtering extracting solution 1 and filtering extracting solution 2, it is concentrated under reduced pressure into medicinal extract shape at 50 DEG C, is recycled in concentration process
Medicinal extract powder obtained by 50-60 DEG C further vacuum drying is finally interwined dragon conopsea extraction by ethyl alcohol；
Wherein, percentage is percentage by volume.
The preparation of skin whitener as described above includes following preparation process：
（1）Weigh weight powder raw material；
（2）By glycerine, Tween-80, ceteareth -20, dipotassium glycyrrhizinate, EDTA- disodiums are uniformly mixed, are heated to
70-80 DEG C, 30-60min is kept the temperature, mixture 1 is obtained；
（3）By fullerene, Herba Blumeae Balsamiferae extract, Semen Celosiae extract, Chinese knotweed's extract, interwined dragon conopsea extraction, citric acid,
Water is uniformly mixed, and is heated to 40-50 DEG C, is kept the temperature 30-60min, is obtained mixture 2；
（4）Mixture 1 is cooled to 40-50 DEG C, mixture 2 is added and stirs evenly, 3000-4000r/min stirs 4-5h, obtains
Skin whitener containing fullerene.
Preferably, step（2）The temperature is 75 DEG C.
Preferably, step（4）The mixing time is 5h.
Advantageous effect：The invention discloses a kind of skin whiteners containing fullerene, and containing active ingredient fullerene, Blumea balsamifera carries
Take object, Semen Celosiae extract, Chinese knotweed's extract, interwined dragon conopsea extraction, this group of compound collaboration obtain the whitening of highly significant
Effect.The Herba Blumeae Balsamiferae extract that new extracting method is prepared through the invention, Semen Celosiae extract, Chinese knotweed's extract,
Interwined dragon conopsea extraction, ingredient are changed with activity, are used in combination with fullerene, and best whitening effect can be reached.
Specific embodiment
A kind of skin whitener containing fullerene of embodiment 1
A kind of skin whitener containing fullerene, including following raw material：.01 parts of fuller olefinic carbon 60,1 part of Herba Blumeae Balsamiferae extract, feather cockscomb
2 parts of seed extract, 0.5 part of Chinese knotweed's extract, 1 part of interwined dragon conopsea extraction, 5 parts of glycerine, 0.5 part of Tween-80, cetearyl alcohol
- 20 0.5 parts of alcohol polyethers, 0.1 part of dipotassium glycyrrhizinate, 0.02 part of EDTA- disodiums, 0.01 part of citric acid, 80 parts of pure water.
The preparation method of the Herba Blumeae Balsamiferae extract is：
（1）Blumea balsamifera 5KG uses 50% alcohol refluxs of 5L to extract 2 times after crushed, each 3h；
（2）Total medicinal extract is obtained after extracting solution evaporated under reduced pressure, total medicinal extract is scattered in 1L water, successively with isometric petroleum ether, acetic acid
Ethyl ester and extracting n-butyl alcohol extract 3 times respectively, and each extraction phase medicinal extract is recovered under reduced pressure to obtain；
（3）Merge petroleum ether and n-butanol fraction to get Herba Blumeae Balsamiferae extract；
Wherein, percentage is percentage by volume.
Preferably, the preparation method of the Semen Celosiae extract is：
（1）The 5KG seed of feather cockscombs are put into 70% ethyl alcohol of its 25L, extracts 2 times, 2 hours every time, merges under the conditions of 50 DEG C
Extracting solution, filtering, filtrate are concentrated in vacuo through solvent is recovered under reduced pressure into seed of feather cockscomb crude extract；
（2）Gained seed of feather cockscomb crude extract is put into the water of its 10L and is dissolved, is 5 with diluted alkaline NaHC03 adjustment pH value, on located
The D101 large pore resin absorption columns managed first are eluted with 4BV water with 1BV/h, then are washed successively with 20%, 40% ethanol water gradient
De-, flow velocity is 1BV/h, collects ethanol eluate, is concentrated under reduced pressure into thick paste；
（3）Step（2）Gained thick paste adds 1KG chromatographic grade silica gel to mix thoroughly, and fine powder is ground into after low-temperature vacuum drying, adds the second of 8 times of amounts
Sour second fat refluxing extraction 3 times 1 hour every time, collects extracting solution, recycling design, and extracting solution low-temperature vacuum drying obtains powder, is added
Ethyl alcohol dissolves, and 4 DEG C are placed crystallization, and gained is crystallized through being drying to obtain Semen Celosiae extract；
Wherein, percentage is percentage by volume.
The preparation method of Chinese knotweed's extract is：
（1）Chinese knotweed's rhizome is shone into dry grinding, 5KG live charcoal female powders are added the hydrochloric acid solution of a concentration of 0.4mol/L of 20L, are put into
It is extracted in 60 DEG C of water-baths, is taken out after extracting 2h, after suction filtration, obtain filtrate, merging filtrate；
（2）Step（1）Gained merging filtrate with alkali tune PH to 7.0, then press filtrate：95% ethyl alcohol weight ratio is 1: 5, by 95% second
Alcohol is added in filtrate, and sealing is placed to complete precipitation；
（3）Ethanol precipitation liquid 4 DEG C, after centrifuging 15min, is finally outwelled into ethyl alcohol above, with anhydrous second through 12000r/min
Alcohol washs 2 times, pellet frozen drying to obtain Chinese knotweed's extract；
Wherein, percentage is percentage by volume.
The preparation method of the interwined dragon conopsea extraction is：
（1）Chinese Ladiestresses Root or Herb medicinal material 1KG is weighed, soaked overnight is thinly sliced, and water 4L is added, and adds cellulase 1g, pectase 1g, 45 DEG C
Reaction 2 hours, then add 95% ethyl alcohol of 2L into extracting solution, 55 DEG C are flowed back 3 hours, and extracting solution 1 is filtered to obtain；
（2）Step（1）Residue obtained plus 70% ethanols of 8L, 55 DEG C are flowed back 2 hours, and extracting solution 2 is filtered to obtain；
（3）Merge filtering extracting solution 1 and filtering extracting solution 2, it is concentrated under reduced pressure into medicinal extract shape at 50 DEG C, is recycled in concentration process
Medicinal extract powder obtained by 50 DEG C further vacuum drying is finally interwined dragon conopsea extraction by ethyl alcohol；
Wherein, percentage is percentage by volume.
The preparation of skin whitener as described above includes following preparation process：
（1）Weigh weight powder raw material；
（2）By glycerine, Tween-80, ceteareth -20, dipotassium glycyrrhizinate, EDTA- disodiums are uniformly mixed, are heated to
70-80 DEG C, 30-60min is kept the temperature, mixture 1 is obtained；
（3）By fullerene, Herba Blumeae Balsamiferae extract, Semen Celosiae extract, Chinese knotweed's extract, interwined dragon conopsea extraction, citric acid,
Water is uniformly mixed, and is heated to 40 DEG C, is kept the temperature 30min, is obtained mixture 2；
（4）Mixture 1 is cooled to 40 DEG C, mixture 2 is added and stirs evenly, 3000r/min stirs 4h, obtains containing fullerene
Skin whitener.
A kind of skin whitener containing fullerene of embodiment 2
A kind of skin whitener containing fullerene, including following raw material：.05 parts of fuller olefinic carbon 60,1.5 parts of Herba Blumeae Balsamiferae extract are green
8 parts of feather cockscomb seed extract, 1.5 parts of Chinese knotweed's extract, 4 parts of interwined dragon conopsea extraction, 12 parts of glycerine, 1.5 parts of Tween-80, spermaceti is hard
- 20 1.2 parts of lipidol polyethers, 0.15 part of dipotassium glycyrrhizinate, 0.6 part of EDTA- disodiums, 0.08 part of citric acid, 110 parts of pure water.
The preparation method of the Herba Blumeae Balsamiferae extract is：
（1）Blumea balsamifera 5KG uses 60% alcohol refluxs of 8L to extract 2 times after crushed, each 3h；
（2）Total medicinal extract is obtained after extracting solution evaporated under reduced pressure, total medicinal extract is scattered in 1.5L water, successively with isometric petroleum ether, second
Acetoacetic ester and extracting n-butyl alcohol extract 3 times respectively, and each extraction phase medicinal extract is recovered under reduced pressure to obtain；
（3）Merge petroleum ether and n-butanol fraction to get Herba Blumeae Balsamiferae extract；
Wherein, percentage is percentage by volume.
The preparation method of the Semen Celosiae extract is：
（1）The 5KG seed of feather cockscombs are put into 75% ethyl alcohol of its 28L, extracts 3 times, 2 hours every time, merges under the conditions of 55 DEG C
Extracting solution, filtering, filtrate are concentrated in vacuo through solvent is recovered under reduced pressure into seed of feather cockscomb crude extract；
（2）Gained seed of feather cockscomb crude extract is put into the water of its 15L and is dissolved, is 5.5 with diluted alkaline NaHC03 adjustment pH value, on
The D101 large pore resin absorption columns handled well are first eluted with 4BV water with 1.2BV/h, then successively with 20%, 40% ethanol water ladder
Degree elution, flow velocity is 1.2BV/h, collects ethanol eluate, is concentrated under reduced pressure into thick paste；
（3）Step（2）Gained thick paste adds 1.5KG chromatographic grade silica gel to mix thoroughly, and fine powder is ground into after low-temperature vacuum drying, add 8 times amount
Ethyl acetate refluxing extraction 3 times 1 hour every time, collects extracting solution, recycling design, and extracting solution low-temperature vacuum drying obtains powder, adds
Enter ethyl alcohol dissolving, 5 DEG C are placed crystallization, and gained is crystallized through being drying to obtain Semen Celosiae extract；
Wherein, percentage is percentage by volume.
Preferably, the preparation method of Chinese knotweed's extract is：
（1）Chinese knotweed's rhizome is shone into dry grinding, 5KG live charcoal female powders are added the hydrochloric acid solution of a concentration of 0.4mol/L of 28L, are put into
It is extracted in 60-70 DEG C of water-bath, is taken out after extracting 2h, after suction filtration, obtain filtrate, merging filtrate；
（2）Step（2）Gained merging filtrate with alkali tune PH to 7.0, then press filtrate：95% ethyl alcohol weight ratio is 1: 5.5, by 95%
Ethyl alcohol is added in filtrate, and sealing is placed to complete precipitation；
（3）Ethanol precipitation liquid 6 DEG C, after centrifuging 18min, is finally outwelled into ethyl alcohol above, with anhydrous second through 12000r/min
Alcohol washs 3 times, pellet frozen drying to obtain Chinese knotweed's extract；
Wherein, percentage is percentage by volume.
The preparation method of the interwined dragon conopsea extraction is：
（1）Chinese Ladiestresses Root or Herb medicinal material 1KG is weighed, soaked overnight is thinly sliced, and water 6L is added, and adds cellulase 1.2g, pectase 1.2g,
45 DEG C are reacted 2.5 hours, then add 95% ethyl alcohol of 3L into extracting solution, and 55 DEG C are flowed back 3 hours, and extracting solution 1 is filtered to obtain；
（2）Step（1）Residue obtained plus 75% ethanols of 9L, 60 DEG C are flowed back 2 hours, and extracting solution 2 is filtered to obtain；
（3）Merge filtering extracting solution 1 and filtering extracting solution 2, it is concentrated under reduced pressure into medicinal extract shape at 50 DEG C, is recycled in concentration process
Medicinal extract powder obtained by 55 DEG C further vacuum drying is finally interwined dragon conopsea extraction by ethyl alcohol；
Wherein, percentage is percentage by volume.
The preparation of skin whitener as described above includes following preparation process：
（1）Weigh weight powder raw material；
（2）By glycerine, Tween-80, ceteareth -20, dipotassium glycyrrhizinate, EDTA- disodiums are uniformly mixed, are heated to
75 DEG C, 30-60min is kept the temperature, mixture 1 is obtained；
（3）By fullerene, Herba Blumeae Balsamiferae extract, Semen Celosiae extract, Chinese knotweed's extract, interwined dragon conopsea extraction, citric acid,
Water is uniformly mixed, and is heated to 45 DEG C, is kept the temperature 30-60min, is obtained mixture 2；
（4）Mixture 1 is cooled to 45 DEG C, mixture 2 is added and stirs evenly, 3500r/min stirs 5h, obtains containing fullerene
Skin whitener.
A kind of skin whitener containing fullerene of embodiment 3
A kind of skin whitener containing fullerene, including following raw material：1.0 parts of fullerene, 3 parts of Herba Blumeae Balsamiferae extract, feather cockscomb
10 parts of seed extract, 2 parts of Chinese knotweed's extract, 10 parts of interwined dragon conopsea extraction, 15 parts of glycerine, 5 parts of Tween-80, cetearyl alcohol
- 20 3 parts of alcohol polyethers, 0.6 part of dipotassium glycyrrhizinate, 0.2 part of EDTA- disodiums, 0.5 part of citric acid, 150 parts of pure water.
The preparation method of the Herba Blumeae Balsamiferae extract is：
（1）Blumea balsamifera 5KG uses 70% alcohol refluxs of 10L to extract 2 times after crushed, each 3h；
（2）Total medicinal extract is obtained after extracting solution evaporated under reduced pressure, total medicinal extract is scattered in 2L water, successively with isometric petroleum ether, acetic acid
Ethyl ester and extracting n-butyl alcohol extract 4 times respectively, and each extraction phase medicinal extract is recovered under reduced pressure to obtain；
（3）Merge petroleum ether and n-butanol fraction to get Herba Blumeae Balsamiferae extract；
Wherein, percentage is percentage by volume.
The preparation method of the Semen Celosiae extract is：
（1）The 5KG seed of feather cockscombs are put into 80% ethyl alcohol of its 30L, extracts 3 times, 2 hours every time, merges under the conditions of 60 DEG C
Extracting solution, filtering, filtrate are concentrated in vacuo through solvent is recovered under reduced pressure into seed of feather cockscomb crude extract；
（2）Gained seed of feather cockscomb crude extract is put into the water of its 20L and is dissolved, is 6 with diluted alkaline NaHC03 adjustment pH value, on located
The D101 large pore resin absorption columns managed first are eluted with 4BV water with 1.5BV/h, then successively with 20%, 40% ethanol water gradient
Elution, flow velocity is 1.5BV/h, collects ethanol eluate, is concentrated under reduced pressure into thick paste；
（3）Step（2）Gained thick paste adds 2KG chromatographic grade silica gel to mix thoroughly, and fine powder is ground into after low-temperature vacuum drying, adds the second of 8 times of amounts
Sour second fat refluxing extraction 3 times 1 hour every time, collects extracting solution, recycling design, and extracting solution low-temperature vacuum drying obtains powder, is added
Ethyl alcohol dissolves, and 8 DEG C are placed crystallization, and gained is crystallized through being drying to obtain Semen Celosiae extract；
Wherein, percentage is percentage by volume.
Preferably, the preparation method of Chinese knotweed's extract is：
（1）Chinese knotweed's rhizome is shone into dry grinding, 5KG live charcoal female powders are added the hydrochloric acid solution of a concentration of 0.4mol/L of 30L, are put into
It is extracted in 70 DEG C of water-baths, is taken out after extracting 2h, after suction filtration, obtain filtrate, merging filtrate；
（2）Step（2）Gained merging filtrate with alkali tune PH to 7.0, then press filtrate：95% ethyl alcohol weight ratio is 1: 6, by 95% second
Alcohol is added in filtrate, and sealing is placed to complete precipitation；
（3）Ethanol precipitation liquid 8 DEG C, after centrifuging 20min, is finally outwelled into ethyl alcohol above, with anhydrous second through 12000r/min
Alcohol washs 3 times, pellet frozen drying to obtain Chinese knotweed's extract；
Wherein, percentage is percentage by volume.
The preparation method of the interwined dragon conopsea extraction is：
（1）Chinese Ladiestresses Root or Herb medicinal material 1KG is weighed, soaked overnight is thinly sliced, and water 8L is added, and adds cellulase 1.5g, pectase 1.5g,
45 DEG C are reacted 3 hours, then add 95% ethyl alcohol of 4L into extracting solution, and 55 DEG C are flowed back 3 hours, and extracting solution 1 is filtered to obtain；
（2）Step（1）Residue obtained plus 80% ethanols of 10L, 65 DEG C are flowed back 2 hours, and extracting solution 2 is filtered to obtain；
（3）Merge filtering extracting solution 1 and filtering extracting solution 2, it is concentrated under reduced pressure into medicinal extract shape at 50 DEG C, is recycled in concentration process
Medicinal extract powder obtained by 60 DEG C further vacuum drying is finally interwined dragon conopsea extraction by ethyl alcohol；
Wherein, percentage is percentage by volume.
The preparation of skin whitener as described above includes following preparation process：
（1）Weigh weight powder raw material；
（2）By glycerine, Tween-80, ceteareth -20, dipotassium glycyrrhizinate, EDTA- disodiums are uniformly mixed, are heated to
80 DEG C, 60min is kept the temperature, mixture 1 is obtained；
（3）By fullerene, Herba Blumeae Balsamiferae extract, Semen Celosiae extract, Chinese knotweed's extract, interwined dragon conopsea extraction, citric acid,
Water is uniformly mixed, and is heated to 50 DEG C, is kept the temperature 60min, is obtained mixture 2；
（4）Mixture 1 is cooled to 50 DEG C, mixture 2 is added and stirs evenly, 4000r/min stirs 5h, obtains containing fullerene
Skin whitener.
Comparative example 1
Comparative example 1 is the difference from example 2 is that be free of fullerene, other components and preparation method are same as Example 2.
Comparative example 2
Comparative example 2 is the difference from example 2 is that be free of Herba Blumeae Balsamiferae extract and Semen Celosiae extract, other components and preparation side
Method is same as Example 2.
Comparative example 3
Comparative example 3 is the difference from example 2 is that be free of Chinese knotweed's extract and interwined dragon conopsea extraction, other components and preparation side
Method is same as Example 2.
Comparative example 4
Commercially available skin whitener.
Effect experiment:
1. light spot effect experiment
The light spot effect of the cosmetics obtained by the various embodiments described above is evaluated by comparative analysis.
1.1 experimental method
Experiment packet：This experiment is divided into experimental group and control group, and wherein experimental group 1-3 is that above-described embodiment 1-- embodiments 3 are made
The cosmetics obtained, control group are the 4 one commercially available skin whitener of cosmetics and comparative example obtained by above-mentioned comparative example 1- comparative examples 3.
Test object：Above-mentioned each group is female middle-aged 30,30-40 Sui, health, no skin disease and allergic disease
History, non-sensitive skin can be by Normalization rule cosmetics, and cooperating personnel complete appraisal as required, have certain
Expressive faculty, the impression after energy actual response use；
Test equipment：VISA digital skin analyzers（The U.S.）、Mexameter MX18（CK Electronic GmbH, moral
State）；Test zone：Cheek region（Laugh line, retroreflective regions, black mole and hair are avoided as possible）；Application method：Morning and evening each 1 daily
It is secondary, persistently use 8 weeks；
Test analysis：By comparing using preceding and comparison diagram using color spot after 8 weeks and after deactivating 8 weeks, evaluation experimental group and right
According to the light spot effect of cosmetics is organized, the average value of each group of people's color spot reduced rate is found out, and efficient.
Table 1：
| Color spot reduced rate（Average value）% | Efficient % | Color spot rebound rate % after deactivating | |
| Experimental group 1 | 80 | 99 | 2 |
| Experimental group 2 | 85 | 100 | 1 |
| Experimental group 3 | 83 | 95 | 3 |
| Control group 1 | 32.1 | 60 | 10 |
| Control group 2 | 28.3 | 55 | 8 |
| Control group 3 | 33.4 | 57 | 11 |
| Control group 4 | 27.6 | 23 | 9 |
Data above proves that the light spot color spot reduced rate of skin whitener of the present invention reaches 80%, and effective percentage reaches 95% or more, significantly excellent
In commercially available light spot product, and do not rebound after deactivating.
2. whitening effect is tested
Using the whitening effect of the double-blind study test evaluation present invention：The skin whitener product prepared according to above-mentioned case is used as and waits for test sample
Product, 1 ~ 3 sample of comparative example is control group, and using commercially available light spot product as comparative example 4, every group of random 20 people selects skin health
Adult's forearm in the regions 3cm × 3cm smear each sample daily once in the morning and once at night as recipient site, subject, it is continuous to smear
45 days, Lab colorimeter systems spectrophotometer (Minolta spectrophotometer CM-2002) is used to measure the change of skin color weekly
Change.In Lab colorimeter systems, with the difference Δ L, Δ a, Δ b of coordinate L, a, b come indicate two kinds stimulation between aberration Δ Eab, i.e.,
Distance between 2 color point of the colour space.
Δ Eab=[(Δ L) 2+ (Δ a) 2+ (Δ b) 2] 1/2.In formula：Since Δ Eab is the composite index of L, a, b, represent
The three-dimensional variation of coloration seeks the average value of every group of Δ Eab so being the appropriate index for evaluating colour of skin variation, as a result as follows.
Table 2：
| Serial number | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 1 | Comparative example 2 | Comparative example 3 | Comparative example 4 | Comparative example 5 |
| ΔEab | 7.4 | 8.1 | 7.6 | 3.2 | 3.4 | 3.6 | 3.7 | 2.8 |
The above result shows that the whitening effect of product skin whitener of the present invention is significantly better than U.S. of comparative example 1 ~ 4 and commercial product
White effect is especially best with embodiment 2.
Claims (10)
1. a kind of skin whitener containing fullerene, which is characterized in that include following raw material：.01-1.0 parts of fuller olefinic carbon 60, Chinese mugwort
Receive fragrant extract 1-3 parts, 2-10 parts of Semen Celosiae extract, 0.5-2 parts of Chinese knotweed's extract, 1-10 parts of interwined dragon conopsea extraction is sweet
It is 5-15 parts oily, 0.5-5 parts of Tween-80, -20 0.5-3 parts of ceteareth, 0.1-0.6 parts of dipotassium glycyrrhizinate,
0.02-0.2 parts of EDTA- disodiums, 0.01-0.5 parts of citric acid, 80-150 parts of pure water.
2. skin whitener according to claim 1, which is characterized in that include following raw material：Fuller olefinic carbon 60 .01-0.5
Part, 1-2 parts of Herba Blumeae Balsamiferae extract, 5-10 parts of Semen Celosiae extract, 1-2 parts of Chinese knotweed's extract, 3-5 parts of interwined dragon conopsea extraction,
10-15 parts of glycerine, 0.5-2 parts of Tween-80, -20 0.5-2 parts of ceteareth, 0.1-0.2 parts of dipotassium glycyrrhizinate,
0.5-0.1 parts of EDTA- disodiums, 0.01-0.1 parts of citric acid, 100-120 parts of pure water.
3. skin whitener according to claim 2, which is characterized in that include following raw material：.05 parts of fuller olefinic carbon 60, Chinese mugwort
Receive 1.5 parts of fragrant extract, 8 parts of Semen Celosiae extract, 1.5 parts of Chinese knotweed's extract, 4 parts of interwined dragon conopsea extraction, 12 parts of glycerine spits
- 80 1.5 parts of temperature, 1.2 parts of ceteareth -20,0.15 part of dipotassium glycyrrhizinate, 0.6 part of EDTA- disodiums, citric acid
0.08 part, 110 parts of pure water.
4. according to any skin whiteners of claim 1-3, which is characterized in that the preparation side of the Herba Blumeae Balsamiferae extract
Method is：
Blumea balsamifera 5KG uses 5-10L 50-70% alcohol refluxs to extract 2 times after crushed, each 3h；
Total medicinal extract is obtained after extracting solution evaporated under reduced pressure, total medicinal extract is scattered in 1-2L water, successively with isometric petroleum ether, acetic acid second
Ester and extracting n-butyl alcohol extract 3-4 times respectively, and each extraction phase medicinal extract is recovered under reduced pressure to obtain；
Merge petroleum ether and n-butanol fraction to get Herba Blumeae Balsamiferae extract；
Wherein, percentage is percentage by volume.
5. according to any skin whiteners of claim 1-3, which is characterized in that the preparation side of the Semen Celosiae extract
Method is：
The 5KG seed of feather cockscombs are put into the ethyl alcohol of the 70%-80% of its 25-30L, are extracted under the conditions of 50-60 DEG C 2-3 times, 2 is small every time
When, merge extracting solution, filtering, filtrate is concentrated in vacuo through solvent is recovered under reduced pressure into seed of feather cockscomb crude extract；
Gained seed of feather cockscomb crude extract is put into the water of its 10-20L and is dissolved, is 5-6 with diluted alkaline NaHC03 adjustment pH value, on located
The D101 large pore resin absorption columns managed first are eluted with 4BV water with 1-1.5BV/h, then successively with 20%, 40% ethanol water ladder
Degree elution, flow velocity is 1-1.5BV/h, collects ethanol eluate, is concentrated under reduced pressure into thick paste；
Step（2）Gained thick paste adds 1-2KG chromatographic grade silica gel to mix thoroughly, and fine powder is ground into after low-temperature vacuum drying, adds the acetic acid of 8 times of amounts
Second fat refluxing extraction 3 times 1 hour every time, collects extracting solution, recycling design, and extracting solution low-temperature vacuum drying obtains powder, and second is added
Alcohol dissolves, and 4-8 DEG C is placed crystallization, and gained is crystallized through being drying to obtain Semen Celosiae extract；
Wherein, percentage is percentage by volume.
6. according to any skin whiteners of claim 1-3, which is characterized in that the preparation method of Chinese knotweed's extract
For：
Chinese knotweed's rhizome is shone into dry grinding, 5KG live charcoal female powders are added the hydrochloric acid solution of a concentration of 0.4mol/L of 20-30L, are put into
It is extracted in 60-70 DEG C of water-bath, is taken out after extracting 2h, after suction filtration, obtain filtrate, merging filtrate；
Step（2）Gained merging filtrate with alkali tune PH to 7.0, then press filtrate：95% ethyl alcohol weight ratio is 1: 5-6, by 95% ethyl alcohol
It is added in filtrate, sealing is placed to complete precipitation；
Ethanol precipitation liquid 4-8 DEG C, after centrifuging 15-20min, is finally outwelled into ethyl alcohol above, use is anhydrous through 12000r/min
Ethyl alcohol washs 2-3 times, pellet frozen drying to obtain Chinese knotweed's extract；
Wherein, percentage is percentage by volume.
7. according to any skin whiteners of claim 1-3, which is characterized in that the preparation method of the interwined dragon conopsea extraction
For：
Chinese Ladiestresses Root or Herb medicinal material 1KG is weighed, soaked overnight is thinly sliced, and water 4-8L is added, and adds cellulase 1-1.5g, pectase 1-
1.5g, 45 DEG C are reacted 2-3 hours, then add 95% ethyl alcohol of 2-4L into extracting solution, and 55 DEG C are flowed back 3 hours, and extracting solution 1 is filtered to obtain；
Step（1）Residue obtained plus 8-10L 70-80% ethanols, 55-65 DEG C is flowed back 2 hours, and extracting solution 2 is filtered to obtain；
Merge filtering extracting solution 1 and filtering extracting solution 2, it is concentrated under reduced pressure into medicinal extract shape at 50 DEG C, second is recycled in concentration process
Medicinal extract powder obtained by 50-60 DEG C further vacuum drying is finally interwined dragon conopsea extraction by alcohol；
Wherein, percentage is percentage by volume.
8. any skin whiteners of claim 1-3, which is characterized in that the preparation of the skin whitener includes that following prepare walks
Suddenly：
Weigh weight powder raw material；
By glycerine, Tween-80, ceteareth -20, dipotassium glycyrrhizinate, EDTA- disodiums are uniformly mixed, are heated to 70-80
DEG C, 30-60min is kept the temperature, mixture 1 is obtained；
By fullerene, Herba Blumeae Balsamiferae extract, Semen Celosiae extract, Chinese knotweed's extract, interwined dragon conopsea extraction, citric acid, water is mixed
It closes uniformly, is heated to 40-50 DEG C, keep the temperature 30-60min, obtain mixture 2；
Mixture 1 is cooled to 40-50 DEG C, mixture 2 is added and stirs evenly, 3000-4000r/min stirs 4-5h, obtains containing richness
Strangle the skin whitener of alkene.
9. skin whitener according to claim 8, which is characterized in that step（2）The temperature is 75 DEG C.
10. skin whitener according to claim 8, which is characterized in that step（4）The mixing time is 5h.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110613619A (en) * | 2019-10-14 | 2019-12-27 | 中山市天图精细化工有限公司 | Fullerene-containing biological sunscreen composition and aerosol |
| CN116172929A (en) * | 2023-03-23 | 2023-05-30 | 植物医生(广东)生物科技有限公司 | Whitening composition and preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106236674A (en) * | 2016-09-22 | 2016-12-21 | 上海新高姿化妆品有限公司 | A kind of compositions with white-skinned face function and the application in cosmetics thereof |
| CN107308085A (en) * | 2017-07-31 | 2017-11-03 | 上海中翊日化有限公司 | A kind of whitening highlights composition and preparation method thereof |
-
2018
- 2018-04-23 CN CN201810364294.4A patent/CN108379099A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106236674A (en) * | 2016-09-22 | 2016-12-21 | 上海新高姿化妆品有限公司 | A kind of compositions with white-skinned face function and the application in cosmetics thereof |
| CN107308085A (en) * | 2017-07-31 | 2017-11-03 | 上海中翊日化有限公司 | A kind of whitening highlights composition and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110613619A (en) * | 2019-10-14 | 2019-12-27 | 中山市天图精细化工有限公司 | Fullerene-containing biological sunscreen composition and aerosol |
| CN116172929A (en) * | 2023-03-23 | 2023-05-30 | 植物医生(广东)生物科技有限公司 | Whitening composition and preparation method and application thereof |
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