CN106215068A - A kind of defying age FENGWANGJIANG KOUFUYE - Google Patents
A kind of defying age FENGWANGJIANG KOUFUYE Download PDFInfo
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- CN106215068A CN106215068A CN201610720530.2A CN201610720530A CN106215068A CN 106215068 A CN106215068 A CN 106215068A CN 201610720530 A CN201610720530 A CN 201610720530A CN 106215068 A CN106215068 A CN 106215068A
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- radix
- fengwangjiang
- koufuye
- defying age
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- 239000007788 liquid Substances 0.000 claims abstract description 26
- 239000003814 drug Substances 0.000 claims abstract description 25
- 238000000605 extraction Methods 0.000 claims abstract description 20
- 239000002994 raw material Substances 0.000 claims abstract description 18
- 239000000203 mixture Substances 0.000 claims abstract description 17
- 235000021551 crystal sugar Nutrition 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000012153 distilled water Substances 0.000 claims abstract description 13
- 235000009392 Vitis Nutrition 0.000 claims abstract description 12
- 241000219095 Vitis Species 0.000 claims abstract description 12
- 210000000582 semen Anatomy 0.000 claims abstract description 12
- 108091005804 Peptidases Proteins 0.000 claims abstract description 11
- 239000004365 Protease Substances 0.000 claims abstract description 11
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims abstract description 11
- 238000002360 preparation method Methods 0.000 claims abstract description 5
- 229910052799 carbon Inorganic materials 0.000 claims description 9
- 241000190633 Cordyceps Species 0.000 claims description 6
- 239000009636 Huang Qi Substances 0.000 claims description 6
- 235000003143 Panax notoginseng Nutrition 0.000 claims description 6
- 241000180649 Panax notoginseng Species 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 2
- 239000004744 fabric Substances 0.000 claims description 2
- 238000000227 grinding Methods 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 230000001954 sterilising effect Effects 0.000 claims description 2
- 238000003825 pressing Methods 0.000 claims 3
- 238000004821 distillation Methods 0.000 claims 1
- 238000004659 sterilization and disinfection Methods 0.000 claims 1
- 241000411851 herbal medicine Species 0.000 abstract description 3
- 231100000957 no side effect Toxicity 0.000 abstract description 3
- 230000009759 skin aging Effects 0.000 abstract description 3
- 238000002372 labelling Methods 0.000 description 7
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 6
- 239000000047 product Substances 0.000 description 4
- 235000013336 milk Nutrition 0.000 description 3
- 239000008267 milk Substances 0.000 description 3
- 210000004080 milk Anatomy 0.000 description 3
- 230000000050 nutritive effect Effects 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 1
- 101710180313 Protease 3 Proteins 0.000 description 1
- 102000019197 Superoxide Dismutase Human genes 0.000 description 1
- 108010012715 Superoxide dismutase Proteins 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 230000004223 radioprotective effect Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 229940109850 royal jelly Drugs 0.000 description 1
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The invention discloses a kind of defying age FENGWANGJIANG KOUFUYE, by forming according to the raw material of weight portion as follows: Lac regis apis 60 ~ 80 parts, Mel 35 ~ 52 parts, Chinese medicine extraction liquid 20 ~ 35 parts, 1.8 ~ 3.8 parts of protease, Semen Vitis viniferae 15 ~ 30 parts, 2 ~ 10 parts of crystal sugar and distilled water 50 ~ 70 parts.This kind of defying age FENGWANGJIANG KOUFUYE composition proportion is reasonable, uses pure natural Chinese herbal medicine formula, can effectively alleviate skin aging, mild in medicine property and, safety has no side effect, and preparation method is simple, it is easy to promote.
Description
Technical field
The present invention relates to health product technology field, be specifically related to a kind of defying age FENGWANGJIANG KOUFUYE.
Background technology
Lac regis apis, has another name called Lac regis apis, is the secretions of the young worker bee pharynx gland cultivating larva in honeycomb, be supplied with by
The food of the larva of queen bee to be become, is also the lifelong food of queen bee.After so-called Lac regis apis is exactly between twenty and fifty Apis edible pollen
A kind of milk of secretion, secondary milk is just as the milk of mammal and great nutritive value and immunologic function and contains
High longevity factor.The color of Lac regis apis is the difference according to Apis edible pollen and slight change, is generally divided into milky
With slightly yellow.
Lac regis apis is the super nutritive product of a kind of high active ingredient, and its nutritional labeling is prone to absorb, and is therefore deeply liked by people
Like.Royal jelly nutritive equilibrium is widely used in making the guarantor having radioprotective, improving the effects such as immunity, promotion intelligent development
Strong product.Lac regis apis has the strongest effect containing superoxide dismutase to reparation and the regeneration of cell, is Lac regis apis tool
There is the main component of senile-resistant efficacy.But, existing defying age Lac regis apis product, relatively low to the utilization rate of dismutase, therefore,
Need to change original formula, it is provided that a kind of defying age FENGWANGJIANG KOUFUYE, with satisfied use requirement.
Summary of the invention
Present invention aim at solving the problems referred to above, it is provided that a kind of defying age FENGWANGJIANG KOUFUYE.
For achieving the above object, the invention provides a kind of defying age FENGWANGJIANG KOUFUYE, by following according to weight portion
Raw material forms: Lac regis apis 60 ~ 80 parts, Mel 35 ~ 52 parts, Chinese medicine extraction liquid 20 ~ 35 parts, 1.8 ~ 3.8 parts of protease, Semen Vitis viniferae 15
~ 30 parts, 2 ~ 10 parts of crystal sugar and distilled water 50 ~ 70 parts.
Described defying age FENGWANGJIANG KOUFUYE, by forming according to the raw material of weight portion as follows: Lac regis apis 63 ~ 75 parts, Mel
38 ~ 46 parts, Chinese medicine extraction liquid 23 ~ 30 parts, 2.1 ~ 3.3 parts of protease, Semen Vitis viniferae 18 ~ 27 parts, 4 ~ 8 parts of crystal sugar and distilled water 52 ~
68 parts.
Described defying age FENGWANGJIANG KOUFUYE, by forming according to the raw material of weight portion as follows: Lac regis apis 70 parts, Mel 40
Part, Chinese medicine extraction liquid 25 parts, 2.6 parts of protease, Semen Vitis viniferae 21 parts, 6 parts of crystal sugar and distilled water 55 parts.
The Chinese medicine extraction liquid of described defying age FENGWANGJIANG KOUFUYE is by forming according to the raw material of weight portion as follows: SHANSHEN 10 ~
15 parts, 5 ~ 12 parts of Cornu Cervi Pantotrichum, Radix Notoginseng 8 ~ 17 parts, Herba Pogostemonis 2 ~ 8 parts, Radix Et Caulis Acanthopanacis Senticosi 16 ~ 21 parts, Radix Rhodiolae 2.6 ~ 5.8 parts, Herba Solani Nigri 12 ~ 15
Part, the Radix Astragali 5 ~ 10 parts, Herb Gynostemmae Pentaphylli 15 ~ 20 parts, Cordyceps 20 ~ 25 parts, Herba Violae 20 ~ 30 parts, Radix Angelicae Pubescentis 21 ~ 33 parts, Rhizoma Kaempferiae 2
~ 6 parts, Radix Gentianae 8 ~ 15 parts, the Radix Angelicae Dahuricae 1 ~ 4 part, Oleum Juglandis 10 ~ 16 parts, Spica Prunellae 16 ~ 22 parts, Radix Angelicae Sinensis 8 ~ 13 parts, Rhizoma Smilacis Glabrae 4 ~ 9
Part, Folium Perillae 5 ~ 12 parts and Ba Ji 2 ~ 9 parts.
The Chinese medicine extraction liquid of described defying age FENGWANGJIANG KOUFUYE is by forming according to the raw material of weight portion as follows: SHANSHEN 12 ~
14 parts, 6 ~ 10 parts of Cornu Cervi Pantotrichum, Radix Notoginseng 10 ~ 15 parts, Herba Pogostemonis 3 ~ 7 parts, Radix Et Caulis Acanthopanacis Senticosi 17 ~ 20 parts, Radix Rhodiolae 2.9 ~ 4.5 parts, Herba Solani Nigri 13 ~ 15
Part, the Radix Astragali 6 ~ 9 parts, Herb Gynostemmae Pentaphylli 16 ~ 19 parts, Cordyceps 21 ~ 23 parts, Herba Violae 23 ~ 26 parts, Radix Angelicae Pubescentis 25 ~ 30 parts, Rhizoma Kaempferiae 3 ~
5 parts, Radix Gentianae 10 ~ 13 parts, the Radix Angelicae Dahuricae 2 ~ 4 parts, Oleum Juglandis 11 ~ 15 parts, Spica Prunellae 18 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 12 parts, Rhizoma Smilacis Glabrae 5 ~ 8
Part, Folium Perillae 7 ~ 10 parts and Ba Ji 3 ~ 6 parts.
The Chinese medicine extraction liquid of described defying age FENGWANGJIANG KOUFUYE is by forming according to the raw material of weight portion as follows: SHANSHEN 13
Part, 8 parts of Cornu Cervi Pantotrichum, Radix Notoginseng 12 parts, Herba Pogostemonis 5 parts, Radix Et Caulis Acanthopanacis Senticosi 18 parts, Radix Rhodiolae 3.5 parts, Herba Solani Nigri 14 parts, the Radix Astragali 7 parts, Herb Gynostemmae Pentaphylli 18
Part, Cordyceps 22 parts, Herba Violae 25 parts, Radix Angelicae Pubescentis 27 parts, Rhizoma Kaempferiae 4 parts, Radix Gentianae 11 parts, the Radix Angelicae Dahuricae 3 parts, Oleum Juglandis 14 parts,
Spica Prunellae 19 parts, Radix Angelicae Sinensis 11 parts, Rhizoma Smilacis Glabrae 7 parts, Folium Perillae 9 parts and Ba Ji 5 parts.
The preparation method of described defying age FENGWANGJIANG KOUFUYE comprises the steps of
1) by Lac regis apis and Mel mix homogeneously, mixture A is obtained.
2) in mixture A, add protease, stand 20min, obtain mixture B.
3) crystal sugar adding distilled water, stirring is completely dissolved to crystal sugar, adds Semen Vitis viniferae, obtains solution C.
4) each raw material in Chinese medicine extraction liquid is pulverized respectively according to the ratio of claim 6, ground, until powder can
By the screen cloth of a diameter of 0.8mm, each component mixing after grinding, add in distilled water, soak 30min, after decocting 5h, will
The medicinal liquid obtained, at 80 DEG C, is incubated 10h, is slowly cooled to room temperature, and filters, obtains filtrate D.Filtrate D is concentrated, makes crude drug dense
Degree reaches 2g/ml, obtains extracting solution E.
5) mixture B is added in solution C, be heated to 40 DEG C, add extracting solution E, stir, 100 DEG C of sterilizings
Process 15min, obtain defying age FENGWANGJIANG KOUFUYE.
Beneficial effects of the present invention: this kind of defying age FENGWANGJIANG KOUFUYE composition proportion is reasonable, uses pure natural Chinese herbal medicine
Formula, can effectively alleviate skin aging, mild in medicine property and, safety has no side effect, and preparation method is simple, it is easy to promote.
Detailed description of the invention
Embodiment 1
In the embodiment of the present invention, a kind of defying age FENGWANGJIANG KOUFUYE is by forming according to the raw material of weight portion as follows: Lac regis apis 60
Part, Mel 35 parts, Chinese medicine extraction liquid 20 parts, 1.8 parts of protease, Semen Vitis viniferae 15 parts, 2 parts of crystal sugar and distilled water 50 parts.
Embodiment 2
In the embodiment of the present invention, a kind of defying age FENGWANGJIANG KOUFUYE is by forming according to the raw material of weight portion as follows: Lac regis apis 80
Part, Mel 52 parts, Chinese medicine extraction liquid 20 parts, protease 3 .8 part, Semen Vitis viniferae 30 parts, 10 parts of crystal sugar and distilled water 70 parts.
Embodiment 3
In the embodiment of the present invention, a kind of defying age FENGWANGJIANG KOUFUYE is by forming according to the raw material of weight portion as follows: Lac regis apis 60
Part, Mel 35 parts, Chinese medicine extraction liquid 35 parts, 1.8 parts of protease, Semen Vitis viniferae 15 parts, 2 parts of crystal sugar and distilled water 50 parts.
The oral liquid of the present invention being used for 400 white mice, is divided into 4 groups, often group 100, wherein 3 groups use reality respectively
Executing the oral liquid of example 1 ~ 3, also one group does not uses.Former according to " frequency dividing cell is the most, and skin anti-aging performance is the best "
Reason, this experiment uses isotope-labelling method, according to the degree containing markd carbon cell, judges anti-oral liquid
Old and feeble performance.
After 6 months, the percent profile containing labelling carbon cell is as shown in the table.
The table 1 percent profile containing labelling carbon cell
Group number of elements | Less than 10% | 10%~40% | 40%~70% | More than 70% | |
Embodiment 1 group | 100 | 32 | 28 | 30 | 10 |
Embodiment 2 groups | 100 | 28 | 32 | 27 | 13 |
Embodiment 3 groups | 100 | 20 | 30 | 30 | 20 |
Contrast groups | 100 | 42 | 38 | 18 | 2 |
The percentage containing labelling carbon cell the most not using the white mice of oral liquid is smaller, and cell divides
Split number of times few, defying age poor-performing.2 groups of Chinese medicine extraction liquid proportions of embodiment 1 group and embodiment are identical, other composition embodiment
2 groups are more than embodiment 1 group, and its percent profile containing labelling carbon cell is essentially identical.Embodiment 1 group and embodiment 3
Organizing other compositions identical, Chinese medicine extraction liquid proportion embodiment 1 group is less than embodiment 3 groups, and it is thin that embodiment 3 groups contains labelling carbon
The percentage ratio of born of the same parents is more than embodiment 1 group.
This kind of defying age FENGWANGJIANG KOUFUYE composition proportion is reasonable, uses pure natural Chinese herbal medicine formula, can effectively alleviate
Skin aging, mild in medicine property and, safety have no side effect, preparation method is simple, it is easy to promote.
The preferred embodiment of the present invention described in detail above.Should be appreciated that those of ordinary skill in the art without
Need creative work just can make many modifications and variations according to the design of the present invention.Therefore, all technology in the art
Personnel are available by logical analysis, reasoning, or a limited experiment the most on the basis of existing technology
Technical scheme, all should be in the protection domain being defined in the patent claims.
Claims (7)
1. a defying age FENGWANGJIANG KOUFUYE, it is characterised in that by forming according to the raw material of weight portion as follows: Lac regis apis 60 ~
80 parts, Mel 35 ~ 52 parts, Chinese medicine extraction liquid 20 ~ 35 parts, 1.8 ~ 3.8 parts of protease, Semen Vitis viniferae 15 ~ 30 parts, 2 ~ 10 parts of crystal sugar and
Distilled water 50 ~ 70 parts.
Defying age FENGWANGJIANG KOUFUYE the most according to claim 1, it is characterised in that by as follows according to the raw material of weight portion
Composition: Lac regis apis 63 ~ 75 parts, Mel 38 ~ 46 parts, Chinese medicine extraction liquid 23 ~ 30 parts, 2.1 ~ 3.3 parts of protease, Semen Vitis viniferae 18 ~ 27
Part, 4 ~ 8 parts of crystal sugar and distilled water 52 ~ 68 parts.
Defying age FENGWANGJIANG KOUFUYE the most according to claim 1, it is characterised in that by as follows according to the raw material of weight portion
Composition: Lac regis apis 70 parts, Mel 40 parts, Chinese medicine extraction liquid 25 parts, 2.6 parts of protease, Semen Vitis viniferae 21 parts, 6 parts of crystal sugar and distillation
55 parts of water.
Defying age FENGWANGJIANG KOUFUYE the most according to claim 1, it is characterised in that described Chinese medicine extraction liquid is by pressing as follows
According to weight portion raw material form: SHANSHEN 10 ~ 15 parts, 5 ~ 12 parts of Cornu Cervi Pantotrichum, Radix Notoginseng 8 ~ 17 parts, Herba Pogostemonis 2 ~ 8 parts, Radix Et Caulis Acanthopanacis Senticosi 16 ~ 21 parts,
Radix Rhodiolae 2.6 ~ 5.8 parts, Herba Solani Nigri 12 ~ 15 parts, the Radix Astragali 5 ~ 10 parts, Herb Gynostemmae Pentaphylli 15 ~ 20 parts, Cordyceps 20 ~ 25 parts, Herba Violae
20 ~ 30 parts, Radix Angelicae Pubescentis 21 ~ 33 parts, Rhizoma Kaempferiae 2 ~ 6 parts, Radix Gentianae 8 ~ 15 parts, the Radix Angelicae Dahuricae 1 ~ 4 part, Oleum Juglandis 10 ~ 16 parts, Spica Prunellae 16 ~
22 parts, Radix Angelicae Sinensis 8 ~ 13 parts, Rhizoma Smilacis Glabrae 4 ~ 9 parts, Folium Perillae 5 ~ 12 parts and Ba Ji 2 ~ 9 parts.
Defying age FENGWANGJIANG KOUFUYE the most according to claim 1, it is characterised in that described Chinese medicine extraction liquid is by pressing as follows
Raw material according to weight portion forms: SHANSHEN 12 ~ 14 parts, 6 ~ 10 parts of Cornu Cervi Pantotrichum, Radix Notoginseng 10 ~ 15 parts, Herba Pogostemonis 3 ~ 7 parts, Radix Et Caulis Acanthopanacis Senticosi 17 ~ 20
Part, Radix Rhodiolae 2.9 ~ 4.5 parts, Herba Solani Nigri 13 ~ 15 parts, the Radix Astragali 6 ~ 9 parts, Herb Gynostemmae Pentaphylli 16 ~ 19 parts, Cordyceps 21 ~ 23 parts, pale reddish brown
Fourth 23 ~ 26 parts, Radix Angelicae Pubescentis 25 ~ 30 parts, Rhizoma Kaempferiae 3 ~ 5 parts, Radix Gentianae 10 ~ 13 parts, the Radix Angelicae Dahuricae 2 ~ 4 parts, Oleum Juglandis 11 ~ 15 parts, Spica Prunellae
18 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 12 parts, Rhizoma Smilacis Glabrae 5 ~ 8 parts, Folium Perillae 7 ~ 10 parts and Ba Ji 3 ~ 6 parts.
Defying age FENGWANGJIANG KOUFUYE the most according to claim 1, it is characterised in that described Chinese medicine extraction liquid is by pressing as follows
According to weight portion raw material form: SHANSHEN 13 parts, 8 parts of Cornu Cervi Pantotrichum, Radix Notoginseng 12 parts, Herba Pogostemonis 5 parts, Radix Et Caulis Acanthopanacis Senticosi 18 parts, Radix Rhodiolae 3.5 parts,
Herba Solani Nigri 14 parts, the Radix Astragali 7 parts, Herb Gynostemmae Pentaphylli 18 parts, Cordyceps 22 parts, Herba Violae 25 parts, Radix Angelicae Pubescentis 27 parts, Rhizoma Kaempferiae 4 parts, Radix Gentianae
11 parts, the Radix Angelicae Dahuricae 3 parts, Oleum Juglandis 14 parts, Spica Prunellae 19 parts, Radix Angelicae Sinensis 11 parts, Rhizoma Smilacis Glabrae 7 parts, Folium Perillae 9 parts and Ba Ji 5 parts.
The preparation method of defying age FENGWANGJIANG KOUFUYE the most according to claim 1, it is characterised in that:
1) by Lac regis apis and Mel mix homogeneously, mixture A is obtained;
2) in mixture A, add protease, stand 20min, obtain mixture B;
3) crystal sugar adding distilled water, stirring is completely dissolved to crystal sugar, adds Semen Vitis viniferae, obtains solution C;
4) each raw material in Chinese medicine extraction liquid is pulverized respectively according to the ratio of claim 6, ground, until powder can pass through
The screen cloth of a diameter of 0.8mm, each component mixing after grinding, add in distilled water, soak 30min, after decocting 5h, will obtain
Medicinal liquid at 80 DEG C, be incubated 10h, be slowly cooled to room temperature, filter, obtain filtrate D;
Filtrate D is concentrated, makes crude drug concentration reach 2g/ml, obtain extracting solution E;
5) mixture B is added in solution C, be heated to 40 DEG C, add extracting solution E, stir, 100 DEG C of sterilization treatment
15min, obtains defying age FENGWANGJIANG KOUFUYE.
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN106692932A (en) * | 2017-01-11 | 2017-05-24 | 葛龙海 | Oral liquid |
CN107411003A (en) * | 2017-07-20 | 2017-12-01 | 明光市昊昊蜂业有限公司 | A kind of queen bee paste composition |
CN107495253A (en) * | 2017-07-20 | 2017-12-22 | 明光市昊昊蜂业有限公司 | A kind of royal jelly honey milk |
CN109349632A (en) * | 2018-11-16 | 2019-02-19 | 安徽迎春草生物科技有限公司 | A kind of anti-aging is welcomed spring careless oral solution and preparation method thereof |
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CN1899093A (en) * | 2006-07-18 | 2007-01-24 | 杭州保灵有限公司 | Method for preparing water soluble royal jelly |
CN103918963A (en) * | 2014-04-26 | 2014-07-16 | 明光市昊昊蜂业有限公司 | Royal jelly oral liquid with liver-protecting effect |
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CN1109348A (en) * | 1994-08-16 | 1995-10-04 | 赵绵生 | Anti-senility and health instant powder and its producing method |
CN1899093A (en) * | 2006-07-18 | 2007-01-24 | 杭州保灵有限公司 | Method for preparing water soluble royal jelly |
CN103918963A (en) * | 2014-04-26 | 2014-07-16 | 明光市昊昊蜂业有限公司 | Royal jelly oral liquid with liver-protecting effect |
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CN106692932A (en) * | 2017-01-11 | 2017-05-24 | 葛龙海 | Oral liquid |
CN107411003A (en) * | 2017-07-20 | 2017-12-01 | 明光市昊昊蜂业有限公司 | A kind of queen bee paste composition |
CN107495253A (en) * | 2017-07-20 | 2017-12-22 | 明光市昊昊蜂业有限公司 | A kind of royal jelly honey milk |
CN109349632A (en) * | 2018-11-16 | 2019-02-19 | 安徽迎春草生物科技有限公司 | A kind of anti-aging is welcomed spring careless oral solution and preparation method thereof |
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