CN103520519A - Gastrodia elata submicron powder effervescent tablet and preparation method thereof - Google Patents
Gastrodia elata submicron powder effervescent tablet and preparation method thereof Download PDFInfo
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- CN103520519A CN103520519A CN201310396713.XA CN201310396713A CN103520519A CN 103520519 A CN103520519 A CN 103520519A CN 201310396713 A CN201310396713 A CN 201310396713A CN 103520519 A CN103520519 A CN 103520519A
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- rhizoma gastrodiae
- effervescent tablet
- superfine powder
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- gastrodia elata
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Abstract
The invention relates to a gastrodia elata submicron powder effervescent tablet and a preparation method thereof. The gastrodia elata submicron powder effervescent tablet and the preparation method thereof are characterized in that full gastrodia elata submicron powder is used as the main material, rhodiola rosea or gynostemma pentaphylla or schisandra chinensis extract, an effervescing agent, a lubricant as well as a flavoring agent are added, uniformly mixed according to an equivalent incremental method and directly pressed into tablets. According to the invention, all nutrient and effect components of the gastrodia elata are kept, disintegration is quick, absorption is quick and bioavailability is improved greatly, and therefore, the gastrodia elata submicron powder effervescent tablet is suitable for being used by middle aged and elderly people as well as brain workers, and has effects of increasing wisdom, strengthening brain, promoting sleep, delaying ageing, and improving memory. Besides, production process is simple, production period is short, products are easier to store, transport and use, and popularization and application value is strong.
Description
Technical field
The present invention relates to a kind of Rhizoma Gastrodiae superfine powder effervescent tablet, the effervescent tablet and the effervescent tablet preparation method that have the effect that increases intelligence, brain-strengthening, hypnotic, slow down aging, raising memory that the Rhizoma Gastrodiae superfine powder of especially take is made as primary raw material.
Background technology
Rhizoma Gastrodiae (
gastrodia elatabl) belong to the orchid family (Orehidaceae), Gastrodia (
gastrodieae) perennial heterotrophism herbaceous plant.Have another name called DINGFENGCAO, clutch grass, celestial being's foot, yellow moccasin flower, rhizoma gastrodiae etc., Rhizoma Gastrodiae is the conventional rare Chinese medicine of doctor at all times, and the clinical practice of existing two thousand years is so far historical, is also green health treasure.Rhizoma Gastrodiae is good at diseases such as treatment dizziness and headache, convulsions tic, numb limbs and tense tendons, rheumatism, bodily pain, language is unsuccessful, blood vessels are obstructed, expectorant carbuncle vapour locks, therefore You“ tri-towns ", the saying of " three is anti-", " one mends ".Be epilepsy, convulsion, rheumatism, calmness, spasmolytic, analgesia, tonify deficiency.Modern pharmacological research shows, Rhizoma Gastrodiae mainly contains four large therapeutical effect: to the calmness of nerve centre system, convulsion and analgesic activity; Cardiotonic to cardiovascular system; There is the effect of resisting oxygen lack and enhancing immunologic function; Meanwhile, Rhizoma Gastrodiae also has good health-care effect.
Radix Rhodiolae (
rhodiola yunnanes) be Crassulaceae (Crassulaceae) rhodiola (
rliodiola.l) perennial herb or undershrub wild plant.It is a kind of medicinal and edible plants resource, Main Function is to improve the adaptive capacity of body to environment, have the several functions such as two-ways regulation, slow down aging, radioprotective, anti-hypoxia, resisting fatigue, prophylaxis of tumours, enhancing immunity and antiviral, its main functional factor is rhodioloside, butyl alcohol.
Herb Gynostemmae Pentaphylli [
gynostemmatispentaphylli (thunb) makino] be Cucurbitaceae (Cucurbitaceae), Gynostemma (
gynostemmaherb) herbaceous perennial vine plant, has another name called Herba Gynostemmatis, Herb Gynostemmae Pentaphylli, gynostemma pentaphyllum makino, Radix Rhodiolae.There is cerebral tonic tranquillizing, protect heart Bao Mai, regulating lipid and reducing weight, blood pressure lowering, hole is tired, defying age, growth promotion, the effects such as cancer-resisting, Herb Gynostemmae Pentaphylli is rich in ginsenoside, polysaccharide, flavone, its total saponin content is four times of Radix Ginseng total saponins, and long-term edible having no side effect, is described as China's " southern Radix Ginseng ", " anticancer rising star ".
Fructus Schisandrae Chinensis (
schisandra chinensis(Turcz.) Baill.) be Magnoliaceae (Magnoliacene) Schizandra (
schisandra) dry mature fruit, list in the earliest Sheng Nong's herbal classic top grade, medical value is high.It is also one of minority medical material having concurrently essence, gas, god's three large tonifications, has the nourishing kidney of astringing the lung, the arresting sweating that promotes the production of body fluid, unsmoothing the sperm and stopping bleeding, the effect of mind tranquilizing and the heart calming.The strong liver of energy QI invigorating, the efficiency of promoting cells exclude refuse, supply more oxygen, construction and uses energy, raising memory and the defence capability of enhancing body to nonspecific stimulation.Its main functional factor is lignanoids (schisandrin, schisandrin B, Fructus Schisandrae Chinensis fat element etc.).
At existing patent CN 101455345A, Folium Eucommiae, Gastrodiac nutritive effervescence decoction piece and manufacturing process thereof, be that to take Folium Eucommiae extract and Rhizoma Gastrodiae extract be raw material, prepares alkali grain and acid particles respectively remix film-making and form with adjuvant.Patent CN 101715959A, a kind of rhizoma gastrodiae effervescent tablet, is to take Rhizoma Gastrodiae extract as raw material, adds milk powder, taurine, after Folium Camelliae sinensis extract and adjuvant stir, tabletting is made.Patent CN 101332189A, a kind of improved gastrodine effervescence tablet and preparation method thereof, is to take gastrodine as raw material, adds adjuvant filler, organic acid, inorganic base, correctives, odor mask, coloring agent and mix lubricant tabletting to form.Above patent has only been utilized one-component or the part component of Rhizoma Gastrodiae, fails to make full use of other effective ingredient (as: polysaccharide, protein, mineral element etc.) in Rhizoma Gastrodiae." Study on Preparation of whole gastrodia tuber effervescent granule ", [preparation technique, 2011, (20), 14:46-47] adopts Rhizoma Gastrodiae impalpable powder is raw material, mixes with effervescent, adhesive, wetting agent, prepares soft material, granulate, tabletting forms.
Summary of the invention
The technical problem that the present invention mainly solves is the defect that overcomes prior art, take Rhizoma Gastrodiae superfine powder as primary raw material, adds Radix Rhodiolae or Herb Gynostemmae Pentaphylli or Fructus Schisandrae Chinensis extrat, effervescent, lubricant and correctives, by after equivalent incremental method mix homogeneously, direct compression.
It is that Rhizoma Gastrodiae superfine powder effervescent tablet is made by the raw material with following weight proportion that the present invention adopts technical scheme.
Rhizoma Gastrodiae superfine powder 20-60 part
Radix Rhodiolae extract 0-6 part
Herb Gynostemmae Pentaphylli extract 0-6 part
Fructus Schisandrae Chinensis extrat 0-6 part
Effervescent 10-50 part
Lubricant 1-5 part
Correctives 0-5 part.
Rhizoma Gastrodiae superfine powder is to take fresh gastrodia elata as raw material, and Rhizoma Gastrodiae is dried to obtain to Rhizoma Gastrodiae powder through microwave deactivating enzyme, defibrination, high pressure homogenize, moment spraying, and Rhizoma Gastrodiae powder is pulverized and obtained Rhizoma Gastrodiae superfine powder with low temperature supersonic jet mill again; Maybe by the first Ordinary pulverization of dry Rhizoma Gastrodiae, then make after micronizing.Rhizoma Gastrodiae superfine powder granularity is 1000-1500 order.
Radix Rhodiolae, Herb Gynostemmae Pentaphylli, Fructus Schisandrae Chinensis extrat are raw material pulverizing, take 50-80%(V/V) ethanol is solvent, solid-to-liquid ratio is 1:5-15, by microwave-assisted, extract 2 times, filtrate is concentrated, and reclaims ethanol, with molecule cutting quantity 2000-5000D filter membrane, at pressure 0.1-0.25MPa, temperature 30-50 ℃ is carried out hyperfiltration treatment, and ultrafiltrate reconcentration is dry, be crushed to 150-200 order, obtain extract.
Effervescent is comprised of organic acid and inorganic base, and organic acid is at least one in citric acid, tartaric acid, citric acid; Inorganic base is at least one in sodium bicarbonate or sodium carbonate.
Lubricant is at least one in micropowder silica gel, magnesium stearate, stearic acid.
Correctives is at least one in glycyrrhizin, protein sugar, stevioside.
Its preparation method is, by Rhizoma Gastrodiae superfine powder with pulverize after Radix Rhodiolae or Herb Gynostemmae Pentaphylli or Fructus Schisandrae Chinensis extrat, effervescent, correctives, lubricant in proportion, after equivalent incremental method mix homogeneously, direct compression.
The effect that the present invention possesses and advantage.
The specific embodiment
Below in conjunction with embodiment, the present invention is described in further detail, but embodiment is not limitation of the invention.
Embodiment 1.
Rhizoma Gastrodiae superfine powder is prepared by following methods: the Rhizoma Gastrodiae of cleaning, removing the peel is killed to enzyme through microwave method and process, defibrination at ambient temperature, it jute pulp is after high pressure homogenize, moment spraying is dried to obtain Rhizoma Gastrodiae powder, and Rhizoma Gastrodiae powder is pulverized to obtain 1000-1500 order Rhizoma Gastrodiae superfine powder with low temperature supersonic jet mill again.
Radix Rhodiolae, Herb Gynostemmae Pentaphylli, Fructus Schisandrae Chinensis extrat are prepared by following methods: by raw material pulverizing to 60-100 order, with 50-80%(V/V) ethanol, solid-to-liquid ratio is 1:5-15, by microwave-assisted, extract 2 times, filtrate is concentrated, and reclaims ethanol, with molecule cutting quantity 3000D filter membrane, at pressure 0.15MPa, temperature 30-50 ℃ is carried out hyperfiltration treatment, obtains removing the ultrafiltrate of macromole and suspended particulate substance, ultrafiltrate reconcentration, dry, pulverize the order to 150-200, obtain extract.
Rhizoma Gastrodiae superfine powder effervescent tablet is by making with the raw material of following weight parts proportioning.
60 parts of Rhizoma Gastrodiae superfine powder
5 parts of Radix Rhodiolae extracts
3 parts of Herb Gynostemmae Pentaphylli extracts
3 parts of Fructus Schisandrae Chinensis extrats
15 parts of citric acids
24 parts of sodium bicarbonate
5 parts of magnesium stearate
5 parts of glycyrrhizins.
Preparation method is: by Rhizoma Gastrodiae superfine powder, and Radix Rhodiolae extract, Herb Gynostemmae Pentaphylli extract, Fructus Schisandrae Chinensis extrat, increases progressively mix homogeneously at mixing tank moderate; Again by citric acid powder, sodium hydrogen carbonate powder, dolomol, glycyrrhizin powder adds, by after equivalent incremental method mix homogeneously, direct compression.
Embodiment 2.
Rhizoma Gastrodiae superfine powder effervescent tablet is by making with the raw material of following weight parts proportioning.
20 parts of Rhizoma Gastrodiae superfine powder
2 parts of Radix Rhodiolae extracts
5 parts of citric acids
8 parts of sodium bicarbonate
1 part of micropowder silica gel
1 part of stevioside.
Preparation method: with embodiment 1.
Embodiment 3.
Rhizoma Gastrodiae superfine powder effervescent tablet is by making with the raw material of following weight parts proportioning.
40 parts of Rhizoma Gastrodiae ultra micros
3 parts of Herb Gynostemmae Pentaphylli extracts
4 parts, tartaric acid
5 parts of sodium carbonate
2 parts of stearic acid.
Preparation method: with embodiment 1.
Embodiment 4.
Rhizoma Gastrodiae superfine powder effervescent tablet is by making with the raw material of following weight parts proportioning.
40 parts of Rhizoma Gastrodiae superfine powder
2 parts of Herb Gynostemmae Pentaphylli extracts
3 parts of Fructus Schisandrae Chinensis extrats
7 parts of citric acids
9 parts of sodium carbonate
3 parts of magnesium stearate
1 part of glycyrrhizin.
Preparation method: with embodiment 1.
The present invention has retained whole nutrition and the functional component of Rhizoma Gastrodiae, bioavailability obtains larger raising, make Rhizoma Gastrodiae that the treatment of body and health care are further strengthened and be expanded, production technology is simple, with short production cycle, product is more easily preserved, is transported and uses, and has stronger propagation and employment and is worth.
The present invention has the effect that increases intelligence, brain-strengthening, hypnotic, slow down aging, raising memory, and disintegrate is fast, and bioavailability is high, easy to use, can, as solid beverage, also can use as buccal tablet.
The embodiment of the present invention 1 product is through many people life-time service, without any side effects, and showing is that sleep quality improves, and in high spirits, resistance increases, hypermnesia.
Typical example.
Lee, man, 53 years old, insomnia, all took sleeping pill before sleeping every night for a long time, and the edible embodiment of the present invention 4 products are after 45 days, and sleep quality significantly improves, and has abandoned sleeping pill.
Liu, female, 48 years old, slurred speech after cerebral infarction, ate the embodiment of the present invention 1 product after 3 months, the obvious improvement of having spoken.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention.All any modifications of doing within the spirit and principles in the present invention, be equal to and replace and improvement etc., within all should being included in protection scope of the present invention.
Claims (5)
1. Rhizoma Gastrodiae superfine powder effervescent tablet and preparation method thereof, is characterized in that: effervescent tablet comprises following weight portion raw material and adjuvant: Rhizoma Gastrodiae superfine powder 20-60 part, Radix Rhodiolae extract 0-6 part, Herb Gynostemmae Pentaphylli extract 0-6 part, Fructus Schisandrae Chinensis extrat 0-6 part, effervescent 10-50 part, lubricant 1-5 part, correctives 0-5 part.
2. a kind of Rhizoma Gastrodiae superfine powder effervescent tablet effervescent tablet according to claim 1 and preparation method thereof, it is characterized in that: described Rhizoma Gastrodiae superfine powder is to take fresh gastrodia elata as raw material, Rhizoma Gastrodiae is dried to obtain to Rhizoma Gastrodiae powder through microwave deactivating enzyme, defibrination, high pressure homogenize, moment spraying, and Rhizoma Gastrodiae powder is pulverized to obtain Rhizoma Gastrodiae superfine powder with low temperature supersonic jet mill again; Maybe by the first Ordinary pulverization of dry Rhizoma Gastrodiae, then make after micronizing; Rhizoma Gastrodiae superfine powder granularity is 1000-1500 order.
3. a kind of Rhizoma Gastrodiae superfine powder effervescent tablet effervescent tablet according to claim 1 and preparation method thereof, is characterized in that: Radix Rhodiolae, Herb Gynostemmae Pentaphylli, Fructus Schisandrae Chinensis extrat are to take 50-80% ethanol as solvent, and solid-to-liquid ratio is 1:5-10, by microwave-assisted, extract 2 times, filtrate is concentrated, and reclaims ethanol, with molecule cutting quantity 2000-5000D filter membrane, at pressure 0.1-0.25MPa, temperature 30-50 ℃ is carried out hyperfiltration treatment, and ultrafiltrate reconcentration is dry, be crushed to 150-200 order, obtain extract.
4. a kind of Rhizoma Gastrodiae superfine powder effervescent tablet effervescent tablet according to claim 1 and preparation method thereof, is characterized in that: described effervescent is comprised of organic acid and inorganic base, and organic acid is at least one in citric acid, tartaric acid, citric acid; Inorganic base is at least one in sodium bicarbonate or sodium carbonate; Lubricant is at least one in micropowder silica gel, magnesium stearate, stearic acid; Correctives is at least one in glycyrrhizin, protein sugar, stevioside.
5. a kind of Rhizoma Gastrodiae superfine powder effervescent tablet effervescent tablet according to claim 1 and preparation method thereof, it is characterized in that: the Radix Rhodiolae by Rhizoma Gastrodiae superfine powder and after pulverizing or Herb Gynostemmae Pentaphylli or Fructus Schisandrae Chinensis extrat, effervescent, correctives, lubricant, by after equivalent incremental method mix homogeneously, direct compression.
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Cited By (6)
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| CN104522460A (en) * | 2014-11-27 | 2015-04-22 | 高铭鸿 | Jerusalem artichoke polysaccharide tablets beneficial for brain |
| CN104547830A (en) * | 2015-02-05 | 2015-04-29 | 广东太阳神集团有限公司 | Oral liquid for strengthening brain and preparation method of oral liquid |
| CN105362720A (en) * | 2015-11-25 | 2016-03-02 | 苏州普罗达生物科技有限公司 | Ultra-micro wall-breaking pulverizing method for rhizoma gastrodiae |
| CN105434895A (en) * | 2014-08-13 | 2016-03-30 | 贵州益佰制药股份有限公司 | Gastrodia elata rhodiola rosea cream and preparation method thereof |
| CN109078122A (en) * | 2018-09-20 | 2018-12-25 | 贵州联盛药业有限公司 | A kind of Rhizoma Gastrodiae broken wall medicine materical crude slice and preparation method thereof |
| CN112970998A (en) * | 2019-12-13 | 2021-06-18 | 湖南省博世康中医药有限公司 | Preparation method of gastrodia elata multifunctional effervescent tablets |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105434895A (en) * | 2014-08-13 | 2016-03-30 | 贵州益佰制药股份有限公司 | Gastrodia elata rhodiola rosea cream and preparation method thereof |
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| CN104547830A (en) * | 2015-02-05 | 2015-04-29 | 广东太阳神集团有限公司 | Oral liquid for strengthening brain and preparation method of oral liquid |
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| CN109078122A (en) * | 2018-09-20 | 2018-12-25 | 贵州联盛药业有限公司 | A kind of Rhizoma Gastrodiae broken wall medicine materical crude slice and preparation method thereof |
| CN112970998A (en) * | 2019-12-13 | 2021-06-18 | 湖南省博世康中医药有限公司 | Preparation method of gastrodia elata multifunctional effervescent tablets |
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Application publication date: 20140122 |