CN103783524B - A kind of Folium Forsythia buccal tablet and preparation method thereof - Google Patents
A kind of Folium Forsythia buccal tablet and preparation method thereof Download PDFInfo
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- 239000006189 buccal tablet Substances 0.000 title claims abstract description 46
- 229940046011 buccal tablet Drugs 0.000 title claims abstract description 44
- 241000555712 Forsythia Species 0.000 title claims abstract description 25
- 238000002360 preparation method Methods 0.000 title claims description 16
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 43
- 241001655769 Androsace Species 0.000 claims abstract description 39
- 241000050051 Chelone glabra Species 0.000 claims abstract description 39
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- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 11
- 239000008367 deionised water Substances 0.000 claims abstract description 9
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 9
- 125000003118 aryl group Chemical group 0.000 claims abstract description 6
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- 239000000306 component Substances 0.000 claims abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 133
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 28
- 239000012141 concentrate Substances 0.000 claims description 28
- 239000000706 filtrate Substances 0.000 claims description 28
- 238000001035 drying Methods 0.000 claims description 26
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 21
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- 239000006228 supernatant Substances 0.000 claims description 21
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- XDQITMCFPPPMBC-TUANDBMESA-N scutelloside Natural products OC[C@H]1O[C@@H](O[C@@H]2O[C@@H]3C[C@H]4[C@H](O)[C@@H](O)[C@@](O)(CO3)[C@@H]24)[C@H](O)[C@@H](O)[C@@H]1O XDQITMCFPPPMBC-TUANDBMESA-N 0.000 claims description 2
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- 239000002994 raw material Substances 0.000 description 6
- QIMGUQIHCNDUKU-UHFFFAOYSA-N 2-[[6-[2-(3,4-dihydroxyphenyl)ethoxy]-3,4,5-trihydroxyoxan-2-yl]methoxy]-6-methyloxane-3,4,5-triol Chemical compound OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OCCC=2C=C(O)C(O)=CC=2)O1 QIMGUQIHCNDUKU-UHFFFAOYSA-N 0.000 description 5
- DTOUWTJYUCZJQD-QJDQKFITSA-N Forsythiaside Natural products C[C@@H]1O[C@H](OC[C@H]2O[C@@H](OCCc3ccc(O)c(O)c3)[C@H](O)[C@@H](O)[C@@H]2OC(=O)C=Cc4ccc(O)c(O)c4)[C@H](O)[C@H](O)[C@H]1O DTOUWTJYUCZJQD-QJDQKFITSA-N 0.000 description 5
- KFFCKOBAHMGTMW-LGQRSHAYSA-N Forsythin Chemical compound C1=C(OC)C(OC)=CC=C1[C@H]1[C@@H](CO[C@@H]2C=3C=C(OC)C(O[C@H]4[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O4)O)=CC=3)[C@@H]2CO1 KFFCKOBAHMGTMW-LGQRSHAYSA-N 0.000 description 5
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 5
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 5
- 206010000269 abscess Diseases 0.000 description 5
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 5
- 229910052782 aluminium Inorganic materials 0.000 description 5
- 239000011888 foil Substances 0.000 description 5
- 229930189432 forsythoside Natural products 0.000 description 5
- 238000000227 grinding Methods 0.000 description 5
- 239000008101 lactose Substances 0.000 description 5
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 5
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 5
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- 235000019477 peppermint oil Nutrition 0.000 description 5
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 5
- 229960002675 xylitol Drugs 0.000 description 5
- 235000010447 xylitol Nutrition 0.000 description 5
- 239000000811 xylitol Substances 0.000 description 5
- 108010004032 Bromelains Proteins 0.000 description 4
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- 235000019835 bromelain Nutrition 0.000 description 4
- 230000002265 prevention Effects 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
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- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
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- 210000002429 large intestine Anatomy 0.000 description 2
- 239000007937 lozenge Substances 0.000 description 2
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- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 201000001245 periodontitis Diseases 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 238000010926 purge Methods 0.000 description 2
- 230000002000 scavenging effect Effects 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
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- 241000894006 Bacteria Species 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to herbal health care foodstuff, the buccal tablet of to be a kind of with Folium Forsythiae extract the be Chinese medicine mixed extract compatibility of main component; Technical problem to be solved is to provide one and has clearing heat and detoxicating, antibacterial anti-inflammatory, antivirus action, effectively can treat the Chinese patent drug buccal tablets of extractive of the mouth diseases such as stomatitis, sphagitis, tonsillitis, chronic laryngitis; The technical scheme adopted is: a kind of Folium Forsythia buccal tablet, comprises functional components, excipients, flavor enhancement, aromatic and deionized water, and described functional components is Folium Forsythiae extract, Baical Skullcap root P.E, umbellate rockjasmine herb or fruit extract and Fructus Chebulae extract.
Description
Technical field
The present invention relates to herbal health care foodstuff, the buccal tablet of to be a kind of with Folium Forsythiae extract the be Chinese medicine mixed extract compatibility of main component.
Background technology
Along with industrialization, urbanization process are accelerated, the various waste gas in air, the continuous discharge of dust, air pollution is comparatively serious.Although the environmental consciousness of people strengthens gradually, municipal pollution problem remains serious.Under this overall situation, the incidence of disease of oral cavity and pharyngolaryngitis also increases gradually.Therefore how effectively this type of disease of prevention and therapy is the object that we study.Make the medicine for the treatment of with Effective Component of Chinese Medicine, and be made into special form, with buccal tablet as administrated method, effectively can reduce dosage, and there is the feature such as long action time, taking convenience, play the result for the treatment of that the mutual compatibility of Chinese medicine produces.
Summary of the invention
The present invention overcomes the deficiencies in the prior art, technical problem to be solved is to provide one and has clearing heat and detoxicating, antibacterial anti-inflammatory, antivirus action, effectively can treat the Chinese patent drug buccal tablets of extractive of the mouth diseases such as stomatitis, sphagitis, tonsillitis, chronic laryngitis.The present invention also aims to the preparation method that a kind of traditional Chinese medicine mouth lozenge containing Folium Forsythia, the root of large-flowered skullcap, umbellate rockjasmine herb or fruit, Fructus Chebulae extract is provided.
For solving the problems of the technologies described above, the technical solution adopted in the present invention is: a kind of Folium Forsythia buccal tablet, comprise functional components, excipients, flavor enhancement, aromatic and deionized water, described functional components is Folium Forsythiae extract, Baical Skullcap root P.E, umbellate rockjasmine herb or fruit extract and Fructus Chebulae extract, described Folium Forsythiae extract accounts for the 5-20% of buccal tablet gross weight, Baical Skullcap root P.E accounts for the 1-10% of buccal tablet gross weight, umbellate rockjasmine herb or fruit extract accounts for the 1-8% of buccal tablet gross weight, and Fructus Chebulae extract accounts for the 1-8% of buccal tablet gross weight.
As preferred a kind of Folium Forsythia buccal tablet, described Folium Forsythiae extract accounts for the 10-15% of buccal tablet gross weight, Baical Skullcap root P.E accounts for the 5-8% of buccal tablet gross weight, and umbellate rockjasmine herb or fruit extract accounts for the 3-5% of buccal tablet gross weight, and Fructus Chebulae extract accounts for the 3-5% of buccal tablet gross weight.
The preparation method of described Folium Forsythiae extract is: adopt supercritical CO
2extraction: Folium Forsythia was pulverized 40 mesh sieves, loads extractor; Be 32 DEG C in temperature, pressure is under 15-20MPa condition, makes CO
2gas from gas becomes liquid Nebulized, after add the ethanol that weight percent concentration is 2.5%, time 2 h; Then material is flowed into separator to be separated, the dregs of a decoction are separated with extract; Adsorb being separated the mixed extract obtained, adsorption time is 4 hours, obtains Folium Forsythiae extract after absorption.
The preparation method of described Baical Skullcap root P.E is: the root of large-flowered skullcap and water are that 1:5-8 mixes with weight ratio, are heated to 80-90 DEG C, soaks twice, 2.5 hours first times, and second time 2 hours, merges liquid, crosses 80 mesh filter screens; Filtrate is adjusted the temperature to 60-70 DEG C, adds hydrochloric acid and regulate pH value to 1.0-2.5, be incubated 4 hours, leave standstill after 8 hours, get supernatant, regulate pH value to 6.0-8.0 with sodium hydroxide solution, then add ethanol, alcohol content percentage by weight is made to reach 50-60%, stir, add the active carbon of 0.1-1%, temperature control 50 DEG C, stir 1 hour, filter; Filtrate regulates pH value to 1.0-2.0 with hydrochloric acid solution, and temperature control 60 DEG C, is incubated 2 hours, leaves standstill 8 hours, gets supernatant, regulates pH value to 6.0-8.0 with ethanol; Reclaim ethanol; When concentrating filtrate to 60 DEG C, relative density is the medicinal extract of 1.2-1.3, and drying under reduced pressure or spraying dry obtain the Baical Skullcap root P.E containing scutelloside.
The preparation of described umbellate rockjasmine herb or fruit extract and Fructus Chebulae extract adopts percolation: umbellate rockjasmine herb or fruit or myrobalan are ground into meal, crosses 40 mesh sieves; Add the ethanol of concentration of volume percent 50% wherein, mix thoroughly, stewing 10-16 hour, loads percolate pot, add the ethanol of the concentration of volume percent 60% of 1-6 times of volume, leave standstill diacolation after 20-24 hour, flow 40-60 drips per minute, diacolation 40-50 hour, filters and obtains filtrate and filter residue; At 60 DEG C, reclaim ethanol, the concentrate A being condensed into relative density 1.1-1.3 is for subsequent use; Be the ethanol of 90% by the concentration of volume percent adding 1-6 times of volume in described filter residue, reflux 5-10 hour at 80 DEG C, gets supernatant and carry out secondary filter, at 60 DEG C, reclaim ethanol, and the concentrate B being condensed into relative density 1.1-1.3 is for subsequent use; Merged by concentrate A and concentrate B, removing residue, centrifugation, after parting liquid is carried out drying, namely obtains umbellate rockjasmine herb or fruit extract or Fructus Chebulae extract.
Modern pharmacological research shows, Folium Forsythiae extract has very strong anti-inflammatory, antibacterial, immunity moderation, scavenging free radicals, oxidation resistant effect.The root of large-flowered skullcap can suppress cariogenic bacteria, effectively can reduce bacterial toxoid, can be used for the prevention and therapy of periodontitis.Umbellate rockjasmine herb or fruit has effect for the treatment of tonsillitis, sphagitis, stomatitis.Myrobalan has unique curative effect for treatment chronic pharyngitis, abscess of throat, cough due to deficiency of the lung etc.
Several Chinese herbal medicine extract combinationally uses has synergistic function, effectively can treat mouth disease, as sphagitis, tonsillitis, chronic laryngitis, abscess of throat etc.
Other batch additives that buccal tablet batching of the present invention comprises excipients, flavor enhancement, aromatic, water and makes needed for tablet, often kind of additive all changes in the normal ranges of buccal tablet formulation.
Excipients selects maltodextrin, milk powder, lactose, xylitol.Its feature of maltodextrin is: melting is good, deposit-free, and consumption is the 20-30% of buccal tablet weight; The mouthfeel of the adjustable buccal tablet of milk powder, lactose, xylitol, has trophism, and consumption accounts for the 10-30% of buccal tablet weight.
Fruit ferment selected by flavor enhancement, and as Fructus Chaenomelis ferment, Bromelain and comprehensive enzyme, it has seasoning effect, strengthening spleen and nourishing stomach, and consumption is the 3-8% of buccal tablet weight.
The volatile oil that aromatic selects Chinese herbal medicine to extract, as peppermint oil, rose wet goods, consumption is the 0.01-2.5% of buccal tablet weight.
Buccal tablet preparation process of the present invention comprises: other of Folium Forsythiae extract, Baical Skullcap root P.E, umbellate rockjasmine herb or fruit extract and Fructus Chebulae extract and proper proportion being prepared burden mixes, pulverizing, granulation, drying, compressing tablet, packaging and get final product.
Compared with prior art the present invention has following beneficial effect.
1, one of the functional component in the present invention's formula Folium Forsythiae extract, its raw material sources are selected from aboundresources, the Folium Forsythia of wide material sources, but not the capsule of weeping forsythia fruit of Chinese medicine medication.Carry out the extraction of active ingredient by Folium Forsythia, have and draw materials extensively, make full use of the advantages such as resource, price are low.Detect according to modern pharmacological research and science simultaneously and show active constituent content contained in Folium Forsythia and be not less than capsule of weeping forsythia fruit, and some active constituent contents are also better than capsule of weeping forsythia fruit.
2, the extracting method that adopts in the present invention is advanced, tool effective component extraction rate is high, save time, safety, standardization and industrialized level comparatively high, be conducive to forming Standardization System industry.
3, make buccal tablet with Folium Forsythiae extract and can treat mouth disease, as treatment abscess of throat, stomatitis etc., there is protection oral cavity inner membrance, reduce the health-care effect of mouth disease, and have effect of purging intense heat and detonicating.Compatible with other Chinese medicines, the effect of Synergistic can be played.
4, be widely used, be applicable to numerous crowd, especially to the crowd easily producing the occupational diseases such as abscess of throat.Buccal tablet of the present invention can directly contain in the oral cavity, and instant, instant effect is a kind of convenient, effective, practical health food, good for health, therefore can be used for industrialization large-scale production.
5, the traditional Chinese medicine mouth lozenge in the present invention, containing the extract of Folium Forsythia, the root of large-flowered skullcap, umbellate rockjasmine herb or fruit and myrobalan, has stronger biological effect.The effect of Folium Forsythiae extract tool clearing heat-fire, shows according to modern scientific research, it has, and very strong anti-inflammatory is antibacterial, immunity moderation, scavenging free radicals, oxidation resistant effect; Root of large-flowered skullcap master returns lung, stomach, large intestine channel, and the fire of kind clearing lung-heat and large intestine, has purging intense heat and detonicating, and effect for the treatment of pharyngalgia hot eyes, bleeding from five sense organs or subcutaneous tissue, can be used for the prevention and therapy of periodontitis, pharyngitis.Umbellate rockjasmine herb or fruit specially controls mouth disease, has unique therapeutic efficiency to tonsillitis, sphagitis, stomatitis; Myrobalan has stronger curative effect to treatment chronic laryngitis, abscess of throat.Several extract is mixed and made into buccal tablet, as local application, and the effective means being prevention and therapy mouth disease and having sore throat, and buccal tablet agents area is definite, means of administration is convenient, and drug treating time is longer.Pass through and other mixed preparing of preparing burden simultaneously, its taste is easily accepted by different patients.We are to patient's administration of different oral problem, and every day, 5-8 sheet, carried out record, and add up healing number after one month, details are in table 1.
Detailed description of the invention
Below in conjunction with specific embodiment, the invention will be further described.
Embodiment 1
A kind of Folium Forsythia buccal tablet, comprise the raw material of following weight: Folium Forsythiae extract 5 parts, Baical Skullcap root P.E 3 parts, umbellate rockjasmine herb or fruit extract 1 part, Fructus Chebulae extract 1 part, maltodextrin 20 parts, milk powder 10 parts, lactose 15 parts, Fructus Chaenomelis ferment 3 parts, peppermint oil 0.01 part, deionized water is appropriate.
Preparation technology:
(1) Folium Forsythia is pulverized 40 mesh sieves, load extractor; Be 32 DEG C in temperature, pressure is under 15MPa condition, makes CO
2gas from gas becomes liquid Nebulized, after add the ethanol that weight percent concentration is 2.5%, time 2 h; Then material is flowed into separator to be separated, the dregs of a decoction are separated with extract; Adsorb being separated the mixed extract obtained, adsorption time is 4 hours, obtains the Folium Forsythiae extract containing forsythin and Forsythoside after absorption;
(2) root of large-flowered skullcap and water are that 1:5 mixes with weight ratio, are heated to 80 DEG C, soak twice, 2.5 hours first times, and second time 2 hours, merges liquid, crosses 80 mesh filter screens; Filtrate is adjusted the temperature to 65 DEG C, add hydrochloric acid and regulate pH value to 1.0, be incubated 4 hours, leave standstill after 8 hours, get supernatant, regulate pH value to 7.2 with sodium hydroxide solution, then add ethanol, alcohol content percentage by weight is made to reach 60%, stir, add the active carbon of 1%, temperature control 50 DEG C, stir 1 hour, filter; Filtrate regulates pH value to 1.0 with hydrochloric acid solution, and temperature control 60 DEG C, is incubated 2 hours, leaves standstill 8 hours, gets supernatant, regulates pH value to 7.0 with ethanol; Reclaim ethanol; When concentrating filtrate to 60 DEG C, relative density is the medicinal extract of 1.2, and drying obtains Baical Skullcap root P.E;
(3) umbellate rockjasmine herb or fruit or myrobalan are ground into meal, cross 40 mesh sieves; Add the ethanol of concentration of volume percent 50% wherein, mix thoroughly, stewing 16 hours, load percolate pot, add the ethanol of the concentration of volume percent 60% of 4 times of volumes, leave standstill diacolation after 24 hours, flow 60 is per minute, diacolation 50 hours, filters and obtains filtrate and filter residue; At 60 DEG C, reclaim ethanol, the concentrate A being condensed into relative density 1.3 is for subsequent use; Be the ethanol of 90% by the concentration of volume percent adding 4 times of volumes in described filter residue, reflux 8 hours at 80 DEG C, get supernatant and carry out secondary filter, at 60 DEG C, reclaim ethanol, the concentrate B being condensed into relative density 1.1 is for subsequent use; Merged by concentrate A and concentrate B, removing residue, centrifugation, after parting liquid is carried out drying, namely obtains umbellate rockjasmine herb or fruit extract or Fructus Chebulae extract;
(4) cross 100 mesh sieves by after Folium Forsythiae extract, Baical Skullcap root P.E, umbellate rockjasmine herb or fruit extract and Fructus Chebulae extract co-grinding, fine powder is prepared burden with excipients and other and is mixed, and spends ionized water and makes particle, crosses 12 mesh sieves.Then carry out drying with boiling-bed drying, with 33 stamping machines, be pressed into the plain sheet of every sheet 0.5g, diameter 12mm.Finally load aluminum foil plate, carry out external packing and get final product.
Embodiment 2
A kind of Folium Forsythia buccal tablet, comprise the raw material of following weight: Folium Forsythiae extract 8 parts, Baical Skullcap root P.E 5 parts, umbellate rockjasmine herb or fruit extract 3 parts, Fructus Chebulae extract 3 parts, maltodextrin 20 parts, milk powder 15 parts, xylitol 10 parts, Bromelain 3 parts, peppermint oil 0.01 part, deionized water is appropriate.
Preparation technology:
(1) Folium Forsythia is pulverized 40 mesh sieves, load extractor; Be 32 DEG C in temperature, pressure is under 18MPa condition, makes CO
2gas from gas becomes liquid Nebulized, after add the ethanol that weight percent concentration is 2.5%, time 2 h; Then material is flowed into separator to be separated, the dregs of a decoction are separated with extract; Adsorb being separated the mixed extract obtained, adsorption time is 4 hours, obtains the Folium Forsythiae extract containing forsythin and Forsythoside after absorption;
(2) root of large-flowered skullcap and water are that 1:7 mixes with weight ratio, are heated to 85 DEG C, soak twice, 2.5 hours first times, and second time 2 hours, merges liquid, crosses 80 mesh filter screens; Filtrate is adjusted the temperature to 70 DEG C, add hydrochloric acid and regulate pH value to 1.5, be incubated 4 hours, leave standstill after 8 hours, get supernatant, regulate pH value to 8.0 with sodium hydroxide solution, then add ethanol, alcohol content percentage by weight is made to reach 58%, stir, add the active carbon of 0.1%, temperature control 50 DEG C, stir 1 hour, filter; Filtrate regulates pH value to 1.5 with hydrochloric acid solution, and temperature control 60 DEG C, is incubated 2 hours, leaves standstill 8 hours, gets supernatant, regulates pH value to 8.0 with ethanol; Reclaim ethanol; When concentrating filtrate to 60 DEG C, relative density is the medicinal extract of 1.2, and drying obtains Baical Skullcap root P.E;
(3) umbellate rockjasmine herb or fruit or myrobalan are ground into meal, cross 40 mesh sieves; Add the ethanol of concentration of volume percent 50% wherein, mix thoroughly, stewing 10 hours, load percolate pot, add the ethanol of the concentration of volume percent 60% of 1 times of volume, leave standstill diacolation after 20 hours, flow 40 is per minute, diacolation 40 hours, filters and obtains filtrate and filter residue; At 60 DEG C, reclaim ethanol, the concentrate A being condensed into relative density 1.1 is for subsequent use; Be the ethanol of 90% by the concentration of volume percent adding 5 times of volumes in described filter residue, reflux 10 hours at 80 DEG C, get supernatant and carry out secondary filter, at 60 DEG C, reclaim ethanol, the concentrate B being condensed into relative density 1.1 is for subsequent use; Merged by concentrate A and concentrate B, removing residue, centrifugation, after parting liquid is carried out drying, namely obtains umbellate rockjasmine herb or fruit extract or Fructus Chebulae extract;
(4) cross 100 mesh sieves by after Folium Forsythiae extract, Baical Skullcap root P.E, umbellate rockjasmine herb or fruit extract and Fructus Chebulae extract co-grinding, fine powder is prepared burden with excipients and other and is mixed, and spends ionized water and makes particle, crosses 12 mesh sieves.Then carry out drying with boiling-bed drying, with 33 stamping machines, be pressed into the plain sheet of every sheet 0.5g, diameter 12mm.Finally load aluminum foil plate, carry out external packing and get final product.
Embodiment 3
A kind of Folium Forsythia buccal tablet, comprise the raw material of following weight: Folium Forsythiae extract 15 parts, Baical Skullcap root P.E 8 parts, umbellate rockjasmine herb or fruit extract 5 parts, Fructus Chebulae extract 5 parts, maltodextrin 30 parts, milk powder 15 parts, xylitol 15 parts, Fructus Chaenomelis ferment 6 parts, attar of rose 2.5 parts, deionized water is appropriate.
Preparation technology:
(1) Folium Forsythia is pulverized 40 mesh sieves, load extractor; Be 32 DEG C in temperature, pressure is under 20MPa condition, makes CO
2gas from gas becomes liquid Nebulized, after add the ethanol that weight percent concentration is 2.5%, time 2 h; Then material is flowed into separator to be separated, the dregs of a decoction are separated with extract; Adsorb being separated the mixed extract obtained, adsorption time is 4 hours, obtains the Folium Forsythiae extract containing forsythin and Forsythoside after absorption;
(2) root of large-flowered skullcap and water are that 1:5 mixes with weight ratio, are heated to 90 DEG C, soak twice, 2.5 hours first times, and second time 2 hours, merges liquid, crosses 80 mesh filter screens; Filtrate is adjusted the temperature to 68 DEG C, add hydrochloric acid and regulate pH value to 1.8, be incubated 4 hours, leave standstill after 8 hours, get supernatant, regulate pH value to 6.0 with sodium hydroxide solution, then add ethanol, alcohol content percentage by weight is made to reach 55%, stir, add the active carbon of 0.5%, temperature control 50 DEG C, stir 1 hour, filter; Filtrate regulates pH value to 2.0 with hydrochloric acid solution, and temperature control 60 DEG C, is incubated 2 hours, leaves standstill 8 hours, gets supernatant, regulates pH value to 6.0 with ethanol; Reclaim ethanol; When concentrating filtrate to 60 DEG C, relative density is the medicinal extract of 1.3, and drying obtains Baical Skullcap root P.E;
(3) umbellate rockjasmine herb or fruit or myrobalan are ground into meal, cross 40 mesh sieves; Add the ethanol of concentration of volume percent 50% wherein, mix thoroughly, stewing 15 hours, load percolate pot, add the ethanol of the concentration of volume percent 60% of 2 times of volumes, leave standstill diacolation after 22 hours, flow 50 is per minute, diacolation 45 hours, filters and obtains filtrate and filter residue; At 60 DEG C, reclaim ethanol, the concentrate A being condensed into relative density 1.3 is for subsequent use; Be the ethanol of 90% by the concentration of volume percent adding 3 times of volumes in described filter residue, reflux 5 hours at 80 DEG C, get supernatant and carry out secondary filter, at 60 DEG C, reclaim ethanol, the concentrate B being condensed into relative density 1.2 is for subsequent use; Merged by concentrate A and concentrate B, removing residue, centrifugation, after parting liquid is carried out drying, namely obtains umbellate rockjasmine herb or fruit extract or Fructus Chebulae extract;
(4) cross 100 mesh sieves by after Folium Forsythiae extract, Baical Skullcap root P.E, umbellate rockjasmine herb or fruit extract and Fructus Chebulae extract co-grinding, fine powder is prepared burden with excipients and other and is mixed, and spends ionized water and makes particle, crosses 12 mesh sieves.Then carry out drying with boiling-bed drying, with 33 stamping machines, be pressed into the plain sheet of every sheet 0.5g, diameter 12mm.Finally load aluminum foil plate, carry out external packing and get final product.
Embodiment 4
A kind of Folium Forsythia buccal tablet, comprise the raw material of following weight: Folium Forsythiae extract 10 parts, Baical Skullcap root P.E 5 parts, umbellate rockjasmine herb or fruit extract 8 parts, Fructus Chebulae extract 8 parts, maltodextrin 30 parts, lactose 10 parts, milk powder 20 parts, Bromelain 8 parts, peppermint oil 0.01 part, deionized water is appropriate.
Preparation technology:
(1) Folium Forsythia is pulverized 40 mesh sieves, load extractor; Be 32 DEG C in temperature, pressure is under 15MPa condition, makes CO
2gas from gas becomes liquid Nebulized, after add the ethanol that weight percent concentration is 2.5%, time 2 h; Then material is flowed into separator to be separated, the dregs of a decoction are separated with extract; Adsorb being separated the mixed extract obtained, adsorption time is 4 hours, obtains the Folium Forsythiae extract containing forsythin and Forsythoside after absorption;
(2) root of large-flowered skullcap and water are that 1:6 mixes with weight ratio, are heated to 84 DEG C, soak twice, 2.5 hours first times, and second time 2 hours, merges liquid, crosses 80 mesh filter screens; Filtrate is adjusted the temperature to 60 DEG C, add hydrochloric acid and regulate pH value to 2.0, be incubated 4 hours, leave standstill after 8 hours, get supernatant, regulate pH value to 7.0 with sodium hydroxide solution, then add ethanol, alcohol content percentage by weight is made to reach 60%, stir, add the active carbon of 0.6%, temperature control 50 DEG C, stir 1 hour, filter; Filtrate regulates pH value to 1.5 with hydrochloric acid solution, and temperature control 60 DEG C, is incubated 2 hours, leaves standstill 8 hours, gets supernatant, regulates pH value to 6.5 with ethanol; Reclaim ethanol; When concentrating filtrate to 60 DEG C, relative density is the medicinal extract of 1.2, and drying obtains Baical Skullcap root P.E;
(3) umbellate rockjasmine herb or fruit or myrobalan are ground into meal, cross 40 mesh sieves; Add the ethanol of concentration of volume percent 50% wherein, mix thoroughly, stewing 12 hours, load percolate pot, add the ethanol of the concentration of volume percent 60% of 6 times of volumes, leave standstill diacolation after 22 hours, flow 45 is per minute, diacolation 44 hours, filters and obtains filtrate and filter residue; At 60 DEG C, reclaim ethanol, the concentrate A being condensed into relative density 1.2 is for subsequent use; Be the ethanol of 90% by the concentration of volume percent adding 3 times of volumes in described filter residue, reflux 6 hours at 80 DEG C, get supernatant and carry out secondary filter, at 60 DEG C, reclaim ethanol, the concentrate B being condensed into relative density 1.3 is for subsequent use; Merged by concentrate A and concentrate B, removing residue, centrifugation, after parting liquid is carried out drying, namely obtains umbellate rockjasmine herb or fruit extract or Fructus Chebulae extract;
(4) cross 100 mesh sieves by after Folium Forsythiae extract, Baical Skullcap root P.E, umbellate rockjasmine herb or fruit extract and Fructus Chebulae extract co-grinding, fine powder is prepared burden with excipients and other and is mixed, and spends ionized water and makes particle, crosses 12 mesh sieves.Then carry out drying with boiling-bed drying, with 33 stamping machines, be pressed into the plain sheet of every sheet 0.5g, diameter 12mm.Finally load aluminum foil plate, carry out external packing and get final product.
Embodiment 5
A kind of Folium Forsythia buccal tablet, comprise the raw material of following weight: Folium Forsythiae extract 20 parts, Baical Skullcap root P.E 10 parts, umbellate rockjasmine herb or fruit extract 8 parts, Fructus Chebulae extract 8 parts, maltodextrin 25 parts, lactose 13 parts, xylitol 13 parts, Bromelain 3 parts, peppermint oil 0.01 part, deionized water is appropriate.
Preparation technology:
(1) Folium Forsythia is pulverized 40 mesh sieves, load extractor; Be 32 DEG C in temperature, pressure is under 20MPa condition, makes CO
2gas from gas becomes liquid Nebulized, after add the ethanol that weight percent concentration is 2.5%, time 2 h; Then material is flowed into separator to be separated, the dregs of a decoction are separated with extract; Adsorb being separated the mixed extract obtained, adsorption time is 4 hours, obtains the Folium Forsythiae extract containing forsythin and Forsythoside after absorption;
(2) root of large-flowered skullcap and water are that 1:8 mixes with weight ratio, are heated to 86 DEG C, soak twice, 2.5 hours first times, and second time 2 hours, merges liquid, crosses 80 mesh filter screens; Filtrate is adjusted the temperature to 70 DEG C, add hydrochloric acid and regulate pH value to 2.5, be incubated 4 hours, leave standstill after 8 hours, get supernatant, regulate pH value to 6.0 with sodium hydroxide solution, then add ethanol, alcohol content percentage by weight is made to reach 50%, stir, add the active carbon of 0.8%, temperature control 50 DEG C, stir 1 hour, filter; Filtrate regulates pH value to 2.0 with hydrochloric acid solution, and temperature control 60 DEG C, is incubated 2 hours, leaves standstill 8 hours, gets supernatant, regulates pH value to 8.0 with ethanol; Reclaim ethanol; When concentrating filtrate to 60 DEG C, relative density is the medicinal extract of 1.3, and drying obtains Baical Skullcap root P.E;
(3) umbellate rockjasmine herb or fruit or myrobalan are ground into meal, cross 40 mesh sieves; Add the ethanol of concentration of volume percent 50% wherein, mix thoroughly, stewing 14 hours, load percolate pot, add the ethanol of the concentration of volume percent 60% of 5 times of volumes, leave standstill diacolation after 21 hours, flow 55 is per minute, diacolation 46 hours, filters and obtains filtrate and filter residue; At 60 DEG C, reclaim ethanol, the concentrate A being condensed into relative density 1.1 is for subsequent use; Be the ethanol of 90% by the concentration of volume percent adding 4 times of volumes in described filter residue, reflux 8 hours at 80 DEG C, get supernatant and carry out secondary filter, at 60 DEG C, reclaim ethanol, the concentrate B being condensed into relative density 1.2 is for subsequent use; Merged by concentrate A and concentrate B, removing residue, centrifugation, after parting liquid is carried out drying, namely obtains umbellate rockjasmine herb or fruit extract or Fructus Chebulae extract;
(4) cross 100 mesh sieves by after Folium Forsythiae extract, Baical Skullcap root P.E, umbellate rockjasmine herb or fruit extract and Fructus Chebulae extract co-grinding, fine powder is prepared burden with excipients and other and is mixed, and spends ionized water and makes particle, crosses 12 mesh sieves.Then carry out drying with boiling-bed drying, with 33 stamping machines, be pressed into the plain sheet of every sheet 0.5g, diameter 12mm.Finally load aluminum foil plate, carry out external packing and get final product.
The present invention can summarize with other the concrete form without prejudice to spirit of the present invention or principal character.Therefore, no matter from which point, above-mentioned embodiment of the present invention all can only be thought explanation of the present invention and can not limit invention, claims indicate scope of the present invention, and scope of the present invention is not pointed out in above-mentioned explanation, therefore, any change in the implication suitable with claims of the present invention and scope, all should think to be included in the scope of claims.
Claims (3)
1. a Folium Forsythia buccal tablet, comprise functional components, excipients, flavor enhancement, aromatic and deionized water, it is characterized in that: described functional components is Folium Forsythiae extract, Baical Skullcap root P.E, umbellate rockjasmine herb or fruit extract and Fructus Chebulae extract, described Folium Forsythiae extract accounts for the 5-20% of buccal tablet gross weight, Baical Skullcap root P.E accounts for the 1-10% of buccal tablet gross weight, umbellate rockjasmine herb or fruit extract accounts for the 1-8% of buccal tablet gross weight, and Fructus Chebulae extract accounts for the 1-8% of buccal tablet gross weight;
The preparation method of described Folium Forsythiae extract is: adopt supercritical CO
2extraction: Folium Forsythia was pulverized 40 mesh sieves, loads extractor; Be 32 DEG C in temperature, pressure is under 15-20MPa condition, makes CO
2gas from gas becomes liquid Nebulized, after add the ethanol that weight percent concentration is 2.5%, time 2 h; Then material is flowed into separator to be separated, the dregs of a decoction are separated with extract; Adsorb being separated the mixed extract obtained, adsorption time is 4 hours, obtains Folium Forsythiae extract after absorption;
The preparation method of described Baical Skullcap root P.E is: the root of large-flowered skullcap and water are that 1:5-8 mixes with weight ratio, are heated to 80-90 DEG C, soaks twice, 2.5 hours first times, and second time 2 hours, merges liquid, crosses 80 mesh filter screens; Filtrate is adjusted the temperature to 60-70 DEG C, adds hydrochloric acid and regulate pH value to 1.0-2.5, be incubated 4 hours, leave standstill after 8 hours, get supernatant, regulate pH value to 6.0-8.0 with sodium hydroxide solution, then add ethanol, alcohol content percentage by weight is made to reach 50-60%, stir, add the active carbon of 0.1-1%, temperature control 50 DEG C, stir 1 hour, filter; Filtrate regulates pH value to 1.0-2.0 with hydrochloric acid solution, and temperature control 60 DEG C, is incubated 2 hours, leaves standstill 8 hours, gets supernatant, regulates pH value to 6.0-8.0 with ethanol; Reclaim ethanol; When concentrating filtrate to 60 DEG C, relative density is the medicinal extract of 1.2-1.3, and drying under reduced pressure or spraying dry obtain the Baical Skullcap root P.E containing scutelloside;
The preparation of described umbellate rockjasmine herb or fruit extract and Fructus Chebulae extract adopts percolation: umbellate rockjasmine herb or fruit or myrobalan are ground into meal, crosses 40 mesh sieves; Add the ethanol of concentration of volume percent 50% wherein, mix thoroughly, stewing 10-16 hour, loads percolate pot, add the ethanol of the concentration of volume percent 60% of 1-6 times of volume, leave standstill diacolation after 20-24 hour, flow 40-60 drips per minute, diacolation 40-50 hour, filters and obtains filtrate and filter residue; At 60 DEG C, reclaim ethanol, the concentrate A being condensed into relative density 1.1-1.3 is for subsequent use; Be the ethanol of 90% by the concentration of volume percent adding 1-6 times of volume in described filter residue, reflux 5-10 hour at 80 DEG C, gets supernatant and carry out secondary filter, at 60 DEG C, reclaim ethanol, and the concentrate B being condensed into relative density 1.1-1.3 is for subsequent use; Merged by concentrate A and concentrate B, removing residue, centrifugation, after parting liquid is carried out drying, namely obtains umbellate rockjasmine herb or fruit extract or Fructus Chebulae extract.
2. a kind of Folium Forsythia buccal tablet according to claim 1, it is characterized in that: described Folium Forsythiae extract accounts for the 10-15% of buccal tablet gross weight, Baical Skullcap root P.E accounts for the 5-8% of buccal tablet gross weight, umbellate rockjasmine herb or fruit extract accounts for the 3-5% of buccal tablet gross weight, and Fructus Chebulae extract accounts for the 3-5% of buccal tablet gross weight.
3. a kind of Folium Forsythia buccal tablet preparation method according to claim 1 and 2, it is characterized in that comprising the steps: Folium Forsythiae extract, Baical Skullcap root P.E, umbellate rockjasmine herb or fruit extract and Fructus Chebulae extract to mix with excipients, flavor enhancement, aromatic and deionized water, through granulation, drying, compressing tablet, packaging and get final product.
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| CN1170587A (en) * | 1996-07-13 | 1998-01-21 | 段永聚 | Shuanghuanglian buccal-tablet made from honeysuckle flower, scutellaria root and forsythia fruit |
| CN1518994A (en) * | 2003-01-23 | 2004-08-11 | 赵德富 | Chinese medicinal prescription for diminishing inflammation, removing toxicity and preventing cancer |
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| KR20120139310A (en) * | 2011-06-17 | 2012-12-27 | 한림대학교 산학협력단 | Oral composition for preventing or treating caries and periodontal disease |
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| CN1170587A (en) * | 1996-07-13 | 1998-01-21 | 段永聚 | Shuanghuanglian buccal-tablet made from honeysuckle flower, scutellaria root and forsythia fruit |
| CN1518994A (en) * | 2003-01-23 | 2004-08-11 | 赵德富 | Chinese medicinal prescription for diminishing inflammation, removing toxicity and preventing cancer |
| CN1939421A (en) * | 2005-09-26 | 2007-04-04 | 孙毅 | Antibacterial and antiviral Chinese medicinal composition |
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