CN104352836A - Compound effervescent tablet containing abelmoschus manihot plant extract and having weight losing function - Google Patents
Compound effervescent tablet containing abelmoschus manihot plant extract and having weight losing function Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/884—Alismataceae (Water-plantain family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Abstract
The invention discloses a compound effervescent tablet containing abelmoschus manihot plant extract and having a weight losing function. The compound effervescent tablet is prepared by raw materials in parts by weight as follows: 50-70 parts of abelmoschus manihot rhizome, 20-50 parts of abelmoschus manihot flowers, 1-5 parts of common lophatherum herbs, 2-5 parts of lotus leaves, 1-5 parts of hawthorns, 1-3 parts of rhizoma alismatis, 1-3 parts of Chinese yam, 1-3 parts of honey, 10-15 parts of citric acid, 8-12 parts of sodium bicarbonate and 10-14 parts of lactose. The method comprises steps as follows: abelmoschus manihot rhizome powder, common lophatherum herbs, lotus leaves, hawthorns, Chinese yam and rhizoma alismatis are uniformly mixed, added with water and extracted, abelmoschus manihot flowers are added with ethanol for extraction, an extracted liquid is concentrated to spray density after alcohol precipitation and water sedimentation, spray drying and granulation are performed, citric acid, sodium bicarbonate and lactose are added, and the mixture is pressed into the tablet and packaged. The compound effervescent tablet having the weight losing function is extracted by full natural plants; and through reasonable formula design, the compound effervescent tablet has special fragrance of abelmoschus manihot, tastes mellow, has a remarkable weight losing effect, doesn't have any side effects and is suitable for long-term taking.
Description
Technical field
The present invention relates to solid beverage technical field, be specifically related to a kind of compound slimming effervescent tablet containing Abelmoschus manihot （L.） Medic.
Background technology
Abelmoschus manihot （L.） Medic (Abelmoschus manihot(L.) Medic.) be Malvaceae Abelmoschus plant, originating in Southwestern China area, is perennial herb, resides and does annual cultivation; HUAMU, yellow, center maroon; Summer at florescence, autumn.Solely holy loose calling after the grinding of this flower single in bright Li Shizhen (1518-1593 A.D.) Compendium of Material Medica, be used for the treatment of the diseases such as swollen ulcer drug.Record according to " Chinese Medicine dictionary ", Abelmoschus manihot （L.） Medic property is pungent, micro-hardship, cool.There is effect of heat-clearing and toxic substances removing, cooling blood for hemostasis, detumescence and apocenosis, modern medicine study finds, Abelmoschus manihot （L.） Medic, except being rich in natural Vitamin E, the biological yellow cave of hydroxyl, plant sterol, catechin, complete protein, high polysaccharide glue, dietary fiber, also contains a large amount of trace element-selenium, zinc, ferrum, multiple non-saponifiable matter etc. useful to human body.Can human endocrine be regulated, strengthen the immunity of human body, improve cardiovascular and microcirculation function, enhancing body oxidation resistance, eliminate human free radical; There is anti-cardiac-cerebral ischemia anoxia, anti-inflammatory analgesic, resisting fatigue, defying age, anti-cancer and cancer-preventing, the magical effects such as blood sugar lowering blood fat merit.
Survey data shows, and nearly more than 45% population of weight of China exceeds standard.Modern is because operating pressure is large, rhythm of life is constantly accelerated, cause causing breakfast not eat, lunch tackles, the bad life habits that supper is eaten and drunk extravagantly, unreasonable and immoderate diet causes fat crowd to increase thereupon, and then bring various disease, as three-hypers disease etc.Therefore, the product with fat-reducing effect arises at the historic moment and lasting.Current diet products on the market focus on fat-reducing effect simply, cause part drinking person to produce the untoward reaction such as dizzy, nauseating, nervous and diarrhoea.
Summary of the invention
The object of this invention is to provide a kind of compound slimming effervescent tablet containing Abelmoschus manihot （L.） Medic plant extract, by rational recipe design, using the basis of Abelmoschus manihot （L.） Medic as diet tea, realize science, safety blood sugar lowering blood fat thus reach fat-reducing object.
For achieving the above object, the present invention is by the following technical solutions:
Containing a compound slimming effervescent tablet for Abelmoschus manihot （L.） Medic, it is made up of the raw material of following weight component: 50 ~ 70 parts, Abelmoschus manihot （L.） Medic rhizome, Flos abelmoschi manihot 20 ~ 50 parts, Herba Lophatheri 1 ~ 5 part, 2 ~ 5 parts, Folium Nelumbinis, Fructus Crataegi 1 ~ 5 part, Rhizoma Alismatis 1 ~ 3 part, citric acid 10 ~ 15 parts, sodium bicarbonate 8 ~ 12 parts and lactose 10 ~ 14 parts.
As the preferred technical solution of the present invention, containing a compound slimming effervescent tablet for Abelmoschus manihot （L.） Medic, it is made up of the raw material of following weight component: 60 parts, Abelmoschus manihot （L.） Medic rhizome, Flos abelmoschi manihot 30 parts, Herba Lophatheri 3 parts, 4 parts, Folium Nelumbinis, Fructus Crataegi 2 parts, Rhizoma Alismatis 1 part, citric acid 12 parts, sodium bicarbonate 10 parts and lactose 12 parts.
Containing a preparation method for the compound slimming effervescent tablet of Abelmoschus manihot （L.） Medic plant extract, step is as follows:
(1) extract: the cleaning of Abelmoschus manihot （L.） Medic rhizome is dried rear fragmentation and obtained Abelmoschus manihot （L.） Medic rhizome powder, by Abelmoschus manihot （L.） Medic rhizome powder, Herba Lophatheri, Folium Nelumbinis, Fructus Crataegi and Rhizoma Alismatis mix homogeneously, then add the water that parts by weight are 200 ~ 300 parts, heated and boiled 3 ~ 5 hours, get the supernatant after staticly settling and be labeled as I; Cleaned by Flos abelmoschi manihot and dry, then parch under the condition of 100 ~ 110 DEG C, broken after cooling, then add the ethanol that parts by weight are 50 ~ 100 parts, under the condition of 70 ~ 80 DEG C, reflux, extract, 2 ~ 3 hours, gets the supernatant and is labeled as II after staticly settling;
(2) concentrated: by I vacuum be-0.08mpa, under temperature is the condition of 75 ~ 80 DEG C, being concentrated into density is 1.14 ~ 1.16g/mL, by II vacuum be-0.08mpa, under temperature is the condition of 50 ~ 65 DEG C, being concentrated into density is 1.18 ~ 1.20g/mL;
(3) precipitate with ethanol: add equivalent ethanol in after concentration I and leave standstill 12 ~ 24h, be heated to 50 ~ 60 DEG C and reclaim ethanol, the time is 1 ~ 2 hour, and reconcentration to density is 1.18 ~ 1.20 g/mL;
(4) water precipitating: by I after precipitate with ethanol and concentrated after II be mixed to get mixed liquor, in mixed liquor, add water, wherein the weight of water is 3 ~ 5 times of mixed liquor weight, and leave standstill 12 ~ 24h, being concentrated into density is 1.12 ~ 1.20 g/mL;
(5) film-making: the mixed liquor spray-drying process after step (4) is concentrated, then add tabletting, packaging after the citric acid of formula ratio, sodium bicarbonate and lactose mix homogeneously, the quality of every sheet is 50 ~ 60mg.
Beneficial effect of the present invention: (1) Abelmoschus manihot （L.） Medic property is pungent, micro-hardship is cool.There is effect of heat-clearing and toxic substances removing, hemostasis and anti-inflammation, detumescence and apocenosis, can human endocrine be regulated, strengthen the immunity of human body, improve cardiovascular and microcirculation function, enhancing body oxidation resistance, eliminate human free radical; There is anti-cardiac-cerebral ischemia anoxia, anti-inflammatory analgesic, resisting fatigue, defying age, anti-cancer and cancer-preventing, the magical effects such as blood sugar lowering blood fat merit.(2) Herba Lophatheri contains the nutrients such as a large amount of flavone, lactone, polysaccharide, chlorophyll, aminoacid, vitamin, trace element, and the flavone in Herba Lophatheri has good antiradical activities, can effectively regulate human body blood fat, and there is antiinflammatory, antibacterial, antiviral, antioxidation, raising immunity Folium Nelumbinis have the effect such as clearing away summer-heat and eliminating dampness, sending up the lucid YANG, cooling blood for hemostasis.(3) recent studies confirms, Folium Nelumbinis has the effect of good blood fat reducing, cholesterol reducing and fat-reducing.(4) Fructus Crataegi appetite-stimulating indigestion-relieving, offsets meat stagnation effect especially and has prevention and cure of cardiovascular disease better simultaneously, reduces blood pressure and cholesterol, vessel softening and diuresis and sedation.(5) Rhizoma Alismatis, promoting diuresis to eliminate damp pathogen, expels the heat-evil treating stranguria, main dysuria, the puckery pain of pyretic stranguria, edema distension; There is effect for reducing blood fat to have protective effect to liver simultaneously.
Compound slimming effervescent tablet containing Abelmoschus manihot （L.） Medic plant extract of the present invention is that natural plant extracts, by rational recipe design, make it have the effect that general effervescent tablet for slimming does not reach, mouthfeel is good, has the peculiar fragrance of Abelmoschus manihot （L.） Medic, is equipped with the delicate fragrance of Folium Nelumbinis and Herba Lophatheri, mellow, fat-reducing effect is obvious, without any side effects, suitable long-term taking.
Body Mass Index (body mass index) conventional is at present called for short BMI, is translated into constitutional index again.It is a kind of index calculating Height Ratio body weight.Circular be with body weight (kilogram, kg) divided by height (rice, m) square, i.e. BMI=body weight/height/height (kg/m2).Research shows, the Body Mass Index of most of individuality and the percentage composition of body fat have obvious dependency, can reflect the obese degree of body preferably, as shown in table 1.
Table 1
Of the present invention containing the fat-reducing of Abelmoschus manihot （L.） Medic compound slimming effervescent tablet and lipid-lowering effect test data:
Choose 160, JIAOZUO AREA, Henan Province Simple Obesity Patient (BMI >=28) and take this compound slimming effervescent tablet containing Abelmoschus manihot （L.） Medic, wherein there is male 80, women 80, the range of age is 14 ~ 60 years old, by random for above-mentioned 160 Simple Obesity Patients, be divided into four test group, often organize 40 patients, wherein test group 1 takes the compound slimming effervescent tablet containing Abelmoschus manihot （L.） Medic plant extract of the embodiment of the present invention 1, test group 2 takes the compound slimming effervescent tablet containing Abelmoschus manihot （L.） Medic of the embodiment of the present invention 2, test group 3 takes the compound slimming effervescent tablet containing Abelmoschus manihot （L.） Medic of the embodiment of the present invention 3, test group 4 takes the compound slimming effervescent tablet containing Abelmoschus manihot （L.） Medic plant extract of the embodiment of the present invention 4.
Take the method for the compound slimming effervescent tablet containing Abelmoschus manihot （L.） Medic plant extract: take once after every day at everyone noon, 1 hour after meal night, each serving by two panels, drink two months continuously.
Fat-reducing effect: the weight in patients of test group 1: 100% declines, and (belong to healthy weight scope) between wherein the BMI of 35 patients is down to 18.5 ~ 24, the BMI of 5 patients is down between 24 ~ 28.The weight in patients of test group 2: 100% declines, and (belong to healthy weight scope) between wherein the BMI of 30 patients is down to 18.5 ~ 24, the BMI of 10 patients is down between 24 ~ 28.The weight in patients of test group 3: 100% declines, and (belong to healthy weight scope) between wherein the BMI of 34 patients is down to 18.5 ~ 24, the BMI of 6 patients is down between 24 ~ 28.The weight in patients of test group 4: 100% declines, and (belong to healthy weight scope) between wherein the BMI of 38 patients is down to 18.5 ~ 24, the BMI of 2 patients is down between 24 ~ 28.All patients stops drinking body weight in later six months and does not obviously rebound, and drinks and all to have no adverse reaction afterwards, and gastrointestinal disturbances absorption function is normal.
Detailed description of the invention
Embodiment 1
The compound slimming effervescent tablet containing Abelmoschus manihot （L.） Medic plant extract of the present embodiment, is made up of the raw material of following weight component: 50 parts, Abelmoschus manihot （L.） Medic rhizome, Flos abelmoschi manihot 20 parts, Herba Lophatheri 1 part, 2 parts, Folium Nelumbinis, Fructus Crataegi 1 part, Rhizoma Alismatis 1 part, citric acid 10 parts, sodium bicarbonate 8 parts and lactose 10 parts.
The preparation method of the compound slimming effervescent tablet containing Abelmoschus manihot （L.） Medic plant extract of the present embodiment, step is as follows:
(1) extract: the cleaning of Abelmoschus manihot （L.） Medic rhizome is dried rear fragmentation and obtained Abelmoschus manihot （L.） Medic rhizome powder, by Abelmoschus manihot （L.） Medic rhizome powder, Herba Lophatheri, Folium Nelumbinis, Fructus Crataegi and Rhizoma Alismatis mix homogeneously, then add the water that parts by weight are 200 parts, heated and boiled 3 hours, get the supernatant after staticly settling and be labeled as I; Cleaned by Flos abelmoschi manihot and dry, then parch under the condition of 100 DEG C, broken after cooling, then add the ethanol that parts by weight are 50 parts, under the condition of 70 DEG C, reflux, extract, 2 hours, gets the supernatant and is labeled as II after staticly settling;
(2) concentrated: by I vacuum be-0.08mpa, under temperature is the condition of 75 DEG C, being concentrated into density is 1.14g/mL, by II vacuum be-0.08mpa, under temperature is the condition of 50 DEG C, being concentrated into density is 1.18g/mL;
(3) precipitate with ethanol: add equivalent ethanol in after concentration I and leave standstill 12h, be heated to 50 DEG C and reclaim ethanol, the time is 1 hour, and reconcentration to density is 1.18 g/mL;
(4) water precipitating: by I after precipitate with ethanol and concentrated after II be mixed to get mixed liquor, in mixed liquor, add the water of mixed liquor 3 times, leave standstill 12h, being concentrated into density is 1.12 g/mL;
(5) film-making: the mixed liquor spray-drying process after step (4) is concentrated, then adds tabletting, packaging after the citric acid of formula ratio, sodium bicarbonate and lactose mix homogeneously.
Embodiment 2
The compound slimming effervescent tablet of the Abelmoschus manihot （L.） Medic plant extract of the present embodiment, is made up of the raw material of following weight component: 70 parts, Abelmoschus manihot （L.） Medic rhizome, Flos abelmoschi manihot 50 parts, Herba Lophatheri 5 parts, 5 parts, Folium Nelumbinis, Fructus Crataegi 5 parts, Rhizoma Alismatis 3 parts, citric acid 15 parts, sodium bicarbonate 12 parts and lactose 14 parts.
The preparation method of the compound slimming effervescent tablet containing Abelmoschus manihot （L.） Medic plant extract of the present embodiment, step is as follows:
(1) extract: the cleaning of Abelmoschus manihot （L.） Medic rhizome is dried rear fragmentation and obtained Abelmoschus manihot （L.） Medic rhizome powder, by Abelmoschus manihot （L.） Medic rhizome powder, Herba Lophatheri, Folium Nelumbinis, Fructus Crataegi and Rhizoma Alismatis mix homogeneously, then add the water that parts by weight are 300 parts, heated and boiled 5 hours, get the supernatant after staticly settling and be labeled as I; Cleaned by Flos abelmoschi manihot and dry, then parch under the condition of 110 DEG C, broken after cooling, then add the ethanol that parts by weight are 100 parts, under the condition of 80 DEG C, reflux, extract, 3 hours, gets the supernatant and is labeled as II after staticly settling;
(2) concentrated: by I vacuum be-0.08mpa, under temperature is the condition of 80 DEG C, being concentrated into density is 1.16g/mL, by II vacuum be-0.08mpa, under temperature is the condition of 65 DEG C, being concentrated into density is 1.20g/mL;
(3) precipitate with ethanol: add equivalent ethanol in after concentration I and leave standstill 24h, be heated to 60 DEG C and reclaim ethanol, the time is 2 hours, and reconcentration to density is 1.20 g/mL;
(4) water precipitating: by I after precipitate with ethanol and concentrated after II be mixed to get mixed liquor, in mixed liquor, add the water of mixed liquor 5 times, leave standstill 24h, being concentrated into density is 1.20 g/mL;
(5) film-making: the mixed liquor spray-drying process after step (4) is concentrated, then adds tabletting, packaging after the citric acid of formula ratio, sodium bicarbonate and lactose mix homogeneously.
Embodiment 3
The compound slimming effervescent tablet of the Abelmoschus manihot （L.） Medic plant extract of the present embodiment, is made up of the raw material of following weight component: 60 parts, Abelmoschus manihot （L.） Medic rhizome, Flos abelmoschi manihot 30 parts, Herba Lophatheri 2 parts, 3 parts, Folium Nelumbinis, Fructus Crataegi 4 parts, Rhizoma Alismatis 2 parts, citric acid 12 parts, sodium bicarbonate 10 parts and lactose 12 parts.
The preparation method of the compound slimming effervescent tablet containing Abelmoschus manihot （L.） Medic plant extract of the present embodiment, step is as follows:
(1) extract: the cleaning of Abelmoschus manihot （L.） Medic rhizome is dried rear fragmentation and obtained Abelmoschus manihot （L.） Medic rhizome powder, by Abelmoschus manihot （L.） Medic rhizome powder, Herba Lophatheri, Folium Nelumbinis, Fructus Crataegi and Rhizoma Alismatis mix homogeneously, then add the water that weight portion is 250 parts, heated and boiled 4 hours, get the supernatant after staticly settling and be labeled as I; Cleaned by Flos abelmoschi manihot and dry, then parch under the condition of 105 DEG C, broken after cooling, then add the ethanol that parts by weight are 80 parts, under the condition of 75 DEG C, reflux, extract, 2.5 hours, gets the supernatant and is labeled as II after staticly settling;
(2) concentrated: by I vacuum be-0.08mpa, under temperature is the condition of 78 DEG C, being concentrated into density is 1.15g/mL, by II vacuum be-0.08mpa, under temperature is the condition of 60 DEG C, being concentrated into density is 1.19g/mL;
(3) precipitate with ethanol: add equivalent ethanol in after concentration I and leave standstill 20h, be heated to 55 DEG C and reclaim ethanol, the time is 1.5 hours, and reconcentration to density is 1.19 g/mL;
(4) water precipitating: by I after precipitate with ethanol and concentrated after II be mixed to get mixed liquor, in mixed liquor, add the water of mixed liquor 4 times, leave standstill 15h, being concentrated into density is 1.15 g/mL;
(5) film-making: the mixed liquor spray-drying process after step (4) is concentrated, then adds tabletting, packaging after the citric acid of formula ratio, sodium bicarbonate and lactose mix homogeneously.
Embodiment 4
The compound slimming effervescent tablet containing Abelmoschus manihot （L.） Medic plant extract of the present embodiment, is made up of the raw material of following weight component: 60 parts, Abelmoschus manihot （L.） Medic rhizome, Flos abelmoschi manihot 30 parts, Herba Lophatheri 3 parts, 4 parts, Folium Nelumbinis, Fructus Crataegi 2 parts, Rhizoma Alismatis 1 part, citric acid 12 parts, sodium bicarbonate 10 parts and lactose 12 parts.
The preparation method of the compound slimming effervescent tablet containing Abelmoschus manihot （L.） Medic plant extract of the present embodiment, step is as follows:
(1) extract: the cleaning of Abelmoschus manihot （L.） Medic rhizome is dried rear fragmentation and obtained Abelmoschus manihot （L.） Medic rhizome powder, by Abelmoschus manihot （L.） Medic rhizome powder, Herba Lophatheri, Folium Nelumbinis, Fructus Crataegi and Rhizoma Alismatis mix homogeneously, then add the water that parts by weight are 280 parts, heated and boiled 4 hours, get the supernatant after staticly settling and be labeled as I; Cleaned by Flos abelmoschi manihot and dry, then parch under the condition of 105 DEG C, broken after cooling, then add the ethanol that parts by weight are 50 ~ 100 parts, under the condition of 78 DEG C, reflux, extract, 3 hours, gets the supernatant and is labeled as II after staticly settling;
(2) concentrated: by I vacuum be-0.08mpa, under temperature is the condition of 80 DEG C, being concentrated into density is 1.14g/mL, by II vacuum be-0.08mpa, under temperature is the condition of 50 ~ 65 DEG C, being concentrated into density is 1.18g/mL;
(3) precipitate with ethanol: add equivalent ethanol in after concentration I and leave standstill 15h, be heated to 58 DEG C and reclaim ethanol, the time is 2 hours, and reconcentration to density is 1.20/mL;
(4) water precipitating: by I after precipitate with ethanol and concentrated after II be mixed to get mixed liquor, in mixed liquor, add the water of mixed liquor 4 times, leave standstill 18h, being concentrated into density is 1.18/mL;
(5) film-making: the mixed liquor spray-drying process after step (4) is concentrated, then adds tabletting, packaging after the citric acid of formula ratio, sodium bicarbonate and lactose mix homogeneously.
The above; be only the specific embodiment of the present invention, but protection scope of the present invention is not limited thereto, anyly belongs to those skilled in the art in the technical scope that the present invention discloses; the change that can expect easily or replacement, all should be encompassed within protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with the protection domain of claim.
Claims (3)
1., containing a compound slimming effervescent tablet for Abelmoschus manihot （L.） Medic plant extract, it is characterized in that it is made up of the raw material of following weight component: 50 ~ 70 parts, Abelmoschus manihot （L.） Medic rhizome, Flos abelmoschi manihot 20 ~ 50 parts, Herba Lophatheri 1 ~ 5 part, 2 ~ 5 parts, Folium Nelumbinis, Fructus Crataegi 1 ~ 5 part, Rhizoma Alismatis 1 ~ 3 part, Rhizoma Dioscoreae 1 ~ 3 part, Mel 1 ~ 3 part, citric acid 10 ~ 15 parts, sodium bicarbonate 8 ~ 12 parts and lactose 10 ~ 14 parts.
2. a kind of compound slimming effervescent tablet containing Abelmoschus manihot （L.） Medic plant extract according to claim 1, is characterized in that it is made up of the raw material of following weight component: 60 parts, Abelmoschus manihot （L.） Medic rhizome, Flos abelmoschi manihot 30 parts, Herba Lophatheri 3 parts, 4 parts, Folium Nelumbinis, Fructus Crataegi 2 parts, Rhizoma Alismatis 1 part, Rhizoma Dioscoreae 2 parts, Mel 1 part, citric acid 12 parts, sodium bicarbonate 10 parts and lactose 12 parts.
3. the preparation method of the compound slimming effervescent tablet containing Abelmoschus manihot （L.） Medic plant extract according to claim 1 and 2, is characterized in that step is as follows:
(1) extract: the cleaning of Abelmoschus manihot （L.） Medic rhizome is dried rear fragmentation and obtained Abelmoschus manihot （L.） Medic rhizome powder, by Abelmoschus manihot （L.） Medic rhizome powder, Herba Lophatheri, Folium Nelumbinis, Fructus Crataegi, Rhizoma Dioscoreae and Rhizoma Alismatis mix homogeneously, then the water that parts by weight are 200 ~ 300 parts is added, heated and boiled 3 ~ 5 hours, gets the supernatant and is labeled as I after staticly settling; Cleaned by Flos abelmoschi manihot and dry, then parch under the condition of 100 ~ 110 DEG C, broken after cooling, then add the ethanol that parts by weight are 50 ~ 100 parts, under the condition of 70 ~ 80 DEG C, reflux, extract, 2 ~ 3 hours, gets the supernatant and is labeled as II after staticly settling;
(2) concentrated: by I vacuum be-0.08mpa, under temperature is the condition of 75 ~ 80 DEG C, being concentrated into density is 1.14 ~ 1.16g/mL, by II vacuum be-0.08mpa, under temperature is the condition of 50 ~ 65 DEG C, being concentrated into density is 1.18 ~ 1.20g/mL;
(3) precipitate with ethanol: add equivalent ethanol in after concentration I and leave standstill 12 ~ 24h, be heated to 50 ~ 60 DEG C and reclaim ethanol, the time is 1 ~ 2 hour, and reconcentration to density is 1.18 ~ 1.20 g/mL;
(4) water precipitating: by I after precipitate with ethanol and concentrated after II be mixed to get mixed liquor, in mixed liquor, add water, wherein the weight of water is 3 ~ 5 times of mixed liquor weight, and leave standstill 12 ~ 24h, being concentrated into density is 1.12 ~ 1.20 g/mL;
(5) film-making: the mixed liquor after step (4) is concentrated and Mel mixing, spray-drying process, then adds tabletting, packaging after the citric acid of formula ratio, sodium bicarbonate and lactose mix homogeneously.
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| CN107198080A (en) * | 2016-03-18 | 2017-09-26 | 陈夫 | A kind of medicinal and edible plant extract effervescent tablet and preparation method thereof |
| CN113498860A (en) * | 2021-06-28 | 2021-10-15 | 武汉轻工大学 | Abelmoschus manihot freeze-dried orally disintegrating tablet and preparation method thereof |
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| CN107198080A (en) * | 2016-03-18 | 2017-09-26 | 陈夫 | A kind of medicinal and edible plant extract effervescent tablet and preparation method thereof |
| CN113498860A (en) * | 2021-06-28 | 2021-10-15 | 武汉轻工大学 | Abelmoschus manihot freeze-dried orally disintegrating tablet and preparation method thereof |
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| CN104352836B (en) | 2017-09-22 |
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