CN102423440B - Traditional Chinese drug effective fraction composition for treating cough, and preparation method thereof - Google Patents
Traditional Chinese drug effective fraction composition for treating cough, and preparation method thereof Download PDFInfo
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- CN102423440B CN102423440B CN 201110432769 CN201110432769A CN102423440B CN 102423440 B CN102423440 B CN 102423440B CN 201110432769 CN201110432769 CN 201110432769 CN 201110432769 A CN201110432769 A CN 201110432769A CN 102423440 B CN102423440 B CN 102423440B
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Abstract
The present invention discloses a traditional Chinese drug effective fraction composition for treating cough, and a preparation method thereof. The traditional Chinese drug effective fraction composition of the present invention comprises lalang grass rhizome, wild dendranthema flower, glabrous greenbrier rhizome, largehead atractylodes rhizome and fine leaf schizonepeta herb. The composition of the present invention has effects of cough relieving and cough preventing, phlegm expelling, diuresis, inflammation or internal heat relieving, and the like, and can be provided for treating symptoms of cough, excessive internal heat, odynuria and the like. In addition, the composition of the present invention has characteristics of no side effects, safety and effectiveness.
Description
Technical field
The present invention relates to the Chinese medicine composition field, be specifically related to a kind of Chinese medicinal effective-part composition that is used for the treatment of cough and preparation method thereof.
Background technology
Cough is the mankind's commonly encountered diseases and frequently-occurring disease, one of modal symptom in people's respiratory system disease, especially often because of often cough of repeated infection, if untimely treatment, very easily cause the lower respiratory infections such as bronchitis, pneumonia, affect the healthy of patient.At present, although it is various to be used for the treatment of the medicament categories of cough, specific drug safely and effectively not, the chemotherapy of clinical practice is comparatively general, and medicine is main mainly with antitussive, analgesic, antiinflammatory, but side effect is large, and danger is higher.The inventor once once cough see a doctor, doctor's prescription is Western medicine, has produced the symptoms such as dizzy after the author has drunk, if wait the occupational staff that need to concentrate on for a long time work for driver, this class medicine is just fully inapplicable, having drunk can be abnormally dangerous.
Summary of the invention
The object of the invention is to the problems such as large according to the side effect that exists in existing Western medicine antitussive, a kind of Chinese medicinal effective-part composition that is used for the treatment of safely and effectively cough is provided.
Another purpose of the present invention is to provide the preparation method of above-mentioned Chinese medicinal effective-part composition.
Above-mentioned purpose of the present invention is achieved by the following technical programs:
Chinese medicine is the valuable feature medicine of China, and different drug matching meetings produces beyond thought curative effect.The present invention finds through overtesting, originally is used for the Rhizoma Smilacis Glabrae of detoxifcation dehumidifying, and the Chinese medicines such as the Rhizoma Atractylodis Macrocephalae that originally are used for invigorating the spleen and benefiting QI, in the treatment cough, specially good effect is arranged.Below detailed content:
A kind of Chinese medicinal effective-part composition that is used for the treatment of cough is characterized in that described compositions is comprised of following component according to the mass fraction meter: Rhizoma Imperatae 33, Flos Chrysanthemi Indici 19, Rhizoma Smilacis Glabrae 26, the Rhizoma Atractylodis Macrocephalae 14 and Herba Schizonepetae 8.
The dosage form that the Chinese medicinal effective-part composition that is used for the treatment of cough of the present invention is fit to processing is tablet, oral liquid or capsule.
The preparation method that is used for the treatment of the Chinese medicinal effective-part composition of cough of the present invention comprises the steps:
(1) get Rhizoma Imperatae, Rhizoma Smilacis Glabrae and Herba Schizonepetae, pulverize, add 20 times of water gagings and decoct 3 times, each 3 hours, merging filtrate after the filtration decocting liquid;
(2) get Flos Chrysanthemi Indici and the Rhizoma Atractylodis Macrocephalae, pulverize, add 10 times of water gagings and decoct 2 times, each 3 hours, merging filtrate after the filtration decocting liquid;
(3) filtrate of step (1) and (2) gained is merged, be evaporated to relative concentration and be 1 ~ 1.3 cream, add ethanol, making it contain the alcohol amount is 65%, and hold over night is filtered, and reclaims ethanol, and is concentrated;
(4) concentrated solution after concentrating adds suitable adjuvant according to conventional formulation technique, is processed into corresponding dosage form.
Compared with prior art, the present invention has following beneficial effect:
(1) compositions of the present invention can be eliminated the phlegm, cough-relieving, be promoted the production of body fluid, but also diuresis, detumescence simultaneously, and have no side effect;
(2) preparation method of the present composition is simple, and yield is high, has effectively kept the effective ingredient of medicine.
The specific embodiment
Further explain the present invention below in conjunction with embodiment, but embodiment does not do any type of restriction to the present invention.
Embodiment 1
Get Rhizoma Imperatae, Rhizoma Smilacis Glabrae and Herba Schizonepetae, pulverize, add 20 times of water gagings and decoct 3 times, each 3 hours, merging filtrate after the filtration decocting liquid; Get again Flos Chrysanthemi Indici and the Rhizoma Atractylodis Macrocephalae, pulverize, add 10 times of water gagings and decoct 2 times, each 3 hours, merging filtrate after the filtration decocting liquid; The filtrate of gained is before merged, be evaporated to relative concentration and be 1.3 cream, add ethanol, making it contain the alcohol amount is 65%, and hold over night is filtered, reclaim ethanol, obtain concentrated solution 500ml, get simple syrup, add above-mentioned concentrated solution, and transfer pH to 3.8 with citric acid, adding distil water stirs to 5000ml, be distributed into after fine straining in the 15ml vial, be packaged to be oral liquid.
This product is brown clear liquid, places in half a year and does not produce muddiness.PH approximately 4, total solid 13.3% left and right.Anemia of pregnant woman, children's avoid use.
Embodiment 2
Clinical observation patient 300 examples, patient all has obvious clinical symptoms and makes a definite diagnosis through the clinicist.
The oral liquid that the oral embodiment 1 of patient makes, the adult measures every day three times, each 15ml.Take the compound recipe Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae as contrast, the oral administered compound Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae, dosage is indicated to specifications and is carried out.After medication, observe once every day, and it's 1 month pasts the patient who cures and whether 3 monthly checks have recurrence.
Therapeutic effect after each age group is taken sees Table 1.
| Grouping | Number of cases | Recovery from illness | Produce effects | Take a turn for the better | Invalid | Obvious effective rate (%) | Have or not recurrence |
| Treatment group | 300 | 137 | 58 | 79 | 26 | 91.3 | Nothing |
| Matched group | 300 | 97 | 69 | 62 | 72 | 76 | 16 examples are arranged |
By table 1 as can be known, the composition oral liquid that embodiment 1 obtains has specially good effect in the treatment cough, and is better than the compound recipe CHUANBEI PIPA GAO, does not recur simultaneously.
Embodiment 3
The oral liquid administration ICR mice of using embodiment 1 to make, body weight 20 ~ 25g, male and female half and half.
Through prerun, the oral liquid toxicity that embodiment 1 makes is very low, does not measure LD50, measures therefore mice is carried out maximum dosage-feeding on the one.Maximum dosage-feeding is 150ml, for 10 times of adult's clinical oral administration dosage, observes none example after 7 days and is poisoned to death, and all healthy survival, prove that thus composition oral liquid of the present invention has no side effect.
Claims (2)
1. Chinese medicine composition that is used for the treatment of cough is characterized in that described compositions made by following raw material according to the mass fraction meter: Rhizoma Imperatae 33, Flos Chrysanthemi Indici 19, Rhizoma Smilacis Glabrae 26, the Rhizoma Atractylodis Macrocephalae 14 and Herba Schizonepetae 8.
2. the described preparation method that is used for the treatment of the Chinese medicine composition of cough of claim 1, is characterized in that comprising the steps: to get Rhizoma Imperatae, Rhizoma Smilacis Glabrae and Herba Schizonepetae, pulverizes, add 20 times of water gagings and decoct 3 times, and each 3 hours, merging filtrate after the filtration decocting liquid; Get again Flos Chrysanthemi Indici and the Rhizoma Atractylodis Macrocephalae, pulverize, add 10 times of water gagings and decoct 2 times, each 3 hours, merging filtrate after the filtration decocting liquid; Again will before the filtrate of gained merge, be evaporated to relative concentration and be 1.3 cream, add ethanol, making it contain the alcohol amount is 65%, and hold over night is filtered, reclaim ethanol, obtain concentrated solution 500ml, get simple syrup, add above-mentioned concentrated solution, and transfer pH to 3.8 with citric acid, adding distil water stirs to 5000ml, be distributed into after fine straining in the 15ml vial, be packaged to be the Chinese medicine composition oral liquid that is used for the treatment of cough.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110432769 CN102423440B (en) | 2011-12-21 | 2011-12-21 | Traditional Chinese drug effective fraction composition for treating cough, and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110432769 CN102423440B (en) | 2011-12-21 | 2011-12-21 | Traditional Chinese drug effective fraction composition for treating cough, and preparation method thereof |
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| CN102423440A CN102423440A (en) | 2012-04-25 |
| CN102423440B true CN102423440B (en) | 2013-06-26 |
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| CN 201110432769 Expired - Fee Related CN102423440B (en) | 2011-12-21 | 2011-12-21 | Traditional Chinese drug effective fraction composition for treating cough, and preparation method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1634288A (en) * | 2004-11-10 | 2005-07-06 | 向静芝 | Pure Chinese herbal medicine pillow for preventing and treating repeated infection of the respiratory tract and preparation technique thereof |
| CN102178864A (en) * | 2011-05-27 | 2011-09-14 | 吴伶 | Chinese medicinal oral liquid for treating amygdalitis |
-
2011
- 2011-12-21 CN CN 201110432769 patent/CN102423440B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1634288A (en) * | 2004-11-10 | 2005-07-06 | 向静芝 | Pure Chinese herbal medicine pillow for preventing and treating repeated infection of the respiratory tract and preparation technique thereof |
| CN102178864A (en) * | 2011-05-27 | 2011-09-14 | 吴伶 | Chinese medicinal oral liquid for treating amygdalitis |
Non-Patent Citations (2)
| Title |
|---|
| "止嗽散治疗小儿咳嗽98例";李凤新等;《光明中医》;20070228;第22卷(第2期);68 * |
| 李凤新等."止嗽散治疗小儿咳嗽98例".《光明中医》.2007,第22卷(第2期),68. |
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| CN102423440A (en) | 2012-04-25 |
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Granted publication date: 20130626 Termination date: 20131221 |