CN102488766B - Chinese medicinal effective fraction composition for treating cough and preparation method thereof - Google Patents
Chinese medicinal effective fraction composition for treating cough and preparation method thereof Download PDFInfo
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- CN102488766B CN102488766B CN 201110432757 CN201110432757A CN102488766B CN 102488766 B CN102488766 B CN 102488766B CN 201110432757 CN201110432757 CN 201110432757 CN 201110432757 A CN201110432757 A CN 201110432757A CN 102488766 B CN102488766 B CN 102488766B
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- chinese medicinal
- cough
- medicinal effective
- treatment
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- 239000000203 mixture Substances 0.000 title claims abstract description 26
- 206010011224 Cough Diseases 0.000 title claims abstract description 20
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 239000003814 drug Substances 0.000 claims abstract description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 15
- 239000007788 liquid Substances 0.000 claims description 13
- 239000002552 dosage form Substances 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 239000006071 cream Substances 0.000 claims description 3
- 239000000706 filtrate Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 239000002671 adjuvant Substances 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims 1
- 208000024891 symptom Diseases 0.000 abstract description 7
- 206010062717 Increased upper airway secretion Diseases 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 5
- 208000026435 phlegm Diseases 0.000 abstract description 5
- 208000002173 dizziness Diseases 0.000 abstract description 4
- 206010047700 Vomiting Diseases 0.000 abstract description 2
- 241000132012 Atractylodes Species 0.000 abstract 1
- 235000006751 Platycodon Nutrition 0.000 abstract 1
- 244000274050 Platycodon grandiflorum Species 0.000 abstract 1
- 241000951473 Schizonepeta Species 0.000 abstract 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000001914 calming effect Effects 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 206010022437 insomnia Diseases 0.000 abstract 1
- 229930189914 platycodon Natural products 0.000 abstract 1
- 230000000630 rising effect Effects 0.000 abstract 1
- 230000008673 vomiting Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 241001425800 Pipa Species 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 2
- 230000000954 anitussive effect Effects 0.000 description 2
- 229940124584 antitussives Drugs 0.000 description 2
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 206010035664 Pneumonia Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 235000020374 simple syrup Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a Chinese medicinal effective fraction composition for treating cough and a preparation method thereof. The Chinese medicinal effective fraction composition consists of platycodon root, dark plum fruit, large-head atractylodes rhizome and fineleaf schizonepeta herb. The composition has the effects of relieving cough, eliminating phlegm, clearing dampness, calming the adverse-rising energy, preventing or arresting vomiting, and the like, can be used for treating damp-phlegm rising, and can be further used for treating symptoms such as insomnia, dizziness and the like. The preparation method of the composition has the advantages of easiness, high yield, effective keeping of active ingredients of a medicament, freeness from side effects, safety and effectiveness.
Description
Technical field
The present invention relates to the Chinese medicine composition field, be specifically related to a kind of Chinese medicinal effective-part composition that is used for the treatment of cough and preparation method thereof.
Background technology
Cough is human commonly encountered diseases and frequently-occurring disease, one of modal symptom in people's respiratory system disease, especially often because of often cough of repeated infection, if untimely treatment, very easily cause the lower respiratory infections such as bronchitis, pneumonia, affect the healthy of patient.At present, although it is various to be used for the treatment of the drug kinds of cough, specific drug safely and effectively not, the chemotherapy of clinical practice is comparatively general, and medicine is main mainly with antitussive, analgesic, antiinflammatory, but side effect is large, and danger is higher.The inventor once once cough see a doctor, doctor's prescription is Western medicine, has produced the symptoms such as dizzy after the author has drunk, if wait the occupational staff that need to concentrate on for a long time work for driver, this class medicine is just fully inapplicable, having drunk can be abnormally dangerous.
Summary of the invention
The object of the invention is to provides a kind of Chinese medicinal effective-part composition that is used for the treatment of safely and effectively cough according to problems such as the side effect that exists in the existing Western medicine antitussive are large.
Another purpose of the present invention is to provide the preparation method of above-mentioned Chinese medicinal effective-part composition.
Above-mentioned purpose of the present invention is achieved by the following technical programs:
A kind of Chinese medicinal effective-part composition that is used for the treatment of cough is comprised of Radix Platycodonis, Fructus Mume, the Rhizoma Atractylodis Macrocephalae and Herba Schizonepetae.
As a kind of preferred version, the described Chinese medicinal effective-part composition that is used for the treatment of cough is comprised of following component according to the mass fraction meter: Radix Platycodonis 58, Fructus Mume 22, the Rhizoma Atractylodis Macrocephalae 15 and Herba Schizonepetae 5.
The dosage form that the Chinese medicinal effective-part composition that is used for the treatment of cough of the present invention is fit to processing is tablet, oral liquid or capsule.
The preparation method that is used for the treatment of the Chinese medicinal effective-part composition of cough of the present invention comprises the steps:
(1) gets Radix Platycodonis, Fructus Mume, the Rhizoma Atractylodis Macrocephalae and Herba Schizonepetae, pulverize, add 8 times of water gagings and decoct each 2 hours 3 times, filter merging filtrate behind the decocting liquid, be evaporated to relative concentration and be 1.1 ~ 1.18 cream, add ethanol, making it contain the alcohol amount is 68%, standing over night is filtered, and Recycled ethanol is concentrated;
(2) concentrated solution after will concentrating adds the adjuvant that is fit to according to conventional formulation technique, is processed into corresponding dosage form.
Compared with prior art, the present invention has following beneficial effect:
(1) the compositions of the present invention damp-phlegm in taste and the lung of can dispelling, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass suppresses to violate on the damp-phlegm;
(2) compositions of the present invention can be eliminated the phlegm, cough-relieving, be promoted the production of body fluid, and also can treat simultaneously the symptoms such as dizzy, has no side effect;
(3) preparation method of the present composition is simple, and yield is high, has effectively kept the effective ingredient of medicine.
The specific embodiment
Further explain the present invention below in conjunction with embodiment, but embodiment does not do any type of restriction to the present invention.
Embodiment 1
Get Radix Platycodonis 58g, Fructus Mume 22g, Rhizoma Atractylodis Macrocephalae 15g and Herba Schizonepetae 5g, be crushed to coarse powder, add 8 times of water gagings and decoct each 2 hours 3 times, filter merging filtrate behind the decocting liquid, be evaporated to relative concentration and be 1.15 cream, add ethanol, making it contain the alcohol amount is 68%, and standing over night is filtered, Recycled ethanol obtains concentrated solution 1000ml, gets simple syrup, add above-mentioned concentrated solution, and transfer pH to 4 with citric acid, adding distil water is to 5000ml, stir, be distributed into behind the fine straining in the 15ml vial, be packaged to be oral liquid.
This product is brown clear liquid, places in half a year and does not produce muddiness.PH approximately 4, total solid about 10%.Contraindication in pregnancy.
Embodiment 2
Clinical observation patient 500 examples, patient all has obvious clinical symptoms and makes a definite diagnosis through the clinicist, and wherein the age span is five months ~ 65 years old, and the course of disease is the longest 8 years, and is the shortest 3 days.
The patient is divided into child group (below 16 years old), adult group (17 ~ 55 years old), old group (more than 55 years old) according to the age, the oral liquid that oral embodiment 1 makes, the adult measures every day three times, each 15ml; Child's group and old man organize the consumption of the oral liquid that all reduces by half.Take the compound recipe CHUANBEI PIPA GAO as contrast, oral administered compound CHUANBEI PIPA GAO, dosage are indicated to specifications and are carried out.Observe once every day after the medication, and it's 1 month pasts the patient who cures and whether 3 monthly checks have recurrence.
Therapeutic effect after each age group is taken sees Table 1.
By table 1 as can be known, the composition oral liquid that embodiment 1 obtains has specially good effect in the treatment cough, and because compound recipe CHUANBEI PIPA GAO, particularly evident in the symptom of the long-term cough for the treatment of, in addition, the patient for the treatment of group shouts in medication, and sleep state all takes a turn for the better, the disease that is accompanied by the patient of the symptoms such as dizziness also alleviates to some extent, does not recur simultaneously.
Embodiment 3
The oral liquid administration ICR mice of using embodiment 1 to make, body weight 20 ~ 25g, male and female half and half.
Through prerun, the oral liquid toxicity that embodiment 1 makes is very low, does not measure LD50, measures therefore mice is carried out maximum dosage-feeding on the one.Maximum dosage-feeding is 150ml, is 10 times of adult's clinical oral administration dosage, shouts in 7 days to observe none example and be poisoned to death, and all healthy survival proves that thus composition oral liquid of the present invention has no side effect.
Claims (3)
1. a Chinese medicinal effective-part composition that is used for the treatment of cough is characterized in that the raw material of Chinese medicine of described compositions is counted according to mass fraction: Radix Platycodonis 58, Fructus Mume 22, the Rhizoma Atractylodis Macrocephalae 15 and Herba Schizonepetae 5.
2. the Chinese medicinal effective-part composition that is used for the treatment of cough according to claim 1 is characterized in that the dosage form that described compositions is fit to process is tablet, oral liquid or capsule.
3. claim 1 or the 2 described preparation methoies that are used for the treatment of the Chinese medicinal effective-part composition of cough is characterized in that comprising the steps:
(1) gets Radix Platycodonis, Fructus Mume, the Rhizoma Atractylodis Macrocephalae and Herba Schizonepetae, pulverize, add 8 times of water gagings and decoct each 2 hours 3 times, filter merging filtrate behind the decocting liquid, be evaporated to relative concentration and be 1.1 ~ 1.18 cream, add ethanol, making it contain the alcohol amount is 68%, standing over night is filtered, and Recycled ethanol is concentrated;
(2) concentrated solution after will concentrating adds the adjuvant that is fit to according to conventional formulation technique, is processed into corresponding dosage form.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110432757 CN102488766B (en) | 2011-12-21 | 2011-12-21 | Chinese medicinal effective fraction composition for treating cough and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110432757 CN102488766B (en) | 2011-12-21 | 2011-12-21 | Chinese medicinal effective fraction composition for treating cough and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102488766A CN102488766A (en) | 2012-06-13 |
| CN102488766B true CN102488766B (en) | 2013-03-27 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 201110432757 Expired - Fee Related CN102488766B (en) | 2011-12-21 | 2011-12-21 | Chinese medicinal effective fraction composition for treating cough and preparation method thereof |
Country Status (1)
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Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| KR100877839B1 (en) * | 2007-06-05 | 2009-01-08 | 권휘정 | Manufacturing Method of Pear Juice and Pear Juice Manufactured thereby |
| CN101219203A (en) * | 2008-01-29 | 2008-07-16 | 喻政民 | Proprietary Chinese medicine for treating cough, asthma and tuberculosis |
| CN101406233A (en) * | 2008-11-12 | 2009-04-15 | 尚铮 | Licorice ballonflower tea |
| CN102078508B (en) * | 2011-01-11 | 2013-04-24 | 上海市儿童医院 | Medicine for treating infantile respiratory tract recurrent infection, preparation method thereof and quality control method thereof |
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Owner name: YUNNAN WENSHAN KUNQI PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: ZHANG QUN Effective date: 20140120 |
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Effective date of registration: 20140120 Address after: 663000 Yunnan Province, Wenshan Zhuang and Miao Autonomous Prefecture West Yan Yanshan County Road 4 km Patentee after: Yunnan Wenshan Kunqi Pharmaceutical Co., Ltd. Address before: The Eastern Development Zone of Guangzhou City, Guangdong province 510000 two Building Room 302 Xinyuan Street Chunhui Patentee before: Zhang Qun |
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Address after: 663000 Yunnan Province, Wenshan Zhuang and Miao Autonomous Prefecture West Yan Yanshan County Road 4 km Patentee after: The female seven Pharmaceutical limited companies of Yunnan mountain of papers Address before: 663000 Yunnan Province, Wenshan Zhuang and Miao Autonomous Prefecture West Yan Yanshan County Road 4 km Patentee before: Yunnan Wenshan Kunqi Pharmaceutical Co., Ltd. |
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Granted publication date: 20130327 Termination date: 20191221 |
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| CF01 | Termination of patent right due to non-payment of annual fee |