CN101716259B - Traditional Chinese medicine composition of effective parts for treating cough and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition of effective parts for treating cough. The composition comprises loquat leaves, dysosma versipellis, mulberries and viola alata burgsd. The invention also discloses a preparation method of the composition. The composition mainly acts on the spleen and the stomach and simultaneously acts on the lung, can eliminate dampness, lower adverse energy, dispel damp phlegm of the spleen and the stomach, calm adverse-rising energy, arrest vomiting, eliminate mass, dissipate stagnation and treat damp phlegm rising, can also be used for treating dizziness, cardiopalmus, insomnia, and the like and is particularly suitable for treating the cough in children. The preparation method of the composition is simple and easy to apply, has high yield and furthest maintains the effective constituents of medicaments.

Description

A kind of effective ingredient in Chinese composition and method of making the same for the treatment of cough

Technical field

The present invention relates to pharmaceutical field, be specifically related to a kind of effective ingredient in Chinese composition and method of making the same for the treatment of cough.

Background technology

Cough is human commonly encountered diseases and frequently-occurring disease, be one of modal symptom of people's respiratory system disease, especially often because of often cough of repeated infection, as untimely treatment, very easily cause lower respiratory infections such as bronchitis, pneumonia, influence patient's physical and mental health and life study.In addition, children's's internal organs are tender and lovely, and the ability of resisting exopathogen on the one hand is low, very easily suffer from cough; On the other hand, because the function imperfection of each internal organs of children's is very responsive to medicine, therefore, the child suffers from the cough back need be very prudent aspect use in the selection of medicine.Moreover the patient who suffers from cough usually can be because cough and asthma cause to fall asleep night, thereby produces insomnia, cardio palmus shape, and therefore, pressing in cough-relieving can Cure for insomnia, the antitussive of cardio palmus.

At present, though it is various to be used for the treatment of the medicament categories of cough, but there is not specific drug safely and effectively, the clinical practice chemotherapy is comparatively general, medicine is many based on antitussive, analgesic, antiinflammatory, but the side effect of clinical application is big, dangerous higher, drug combination with antipyretic such as acetaminophen, aspirin phenacetin caffeine and antibiotics antibiotic medicine, more strengthened the particularly clinical application risk of child patient of patient, therefore, developing safely and effectively, cough suppressing medicine has good social benefit and economic benefit.

China tradition Chinese medicine applicating history is long, when the preparation cough suppressing medicine many with Folium Eriobotryae as raw material, but because preparation method is selected for use improperly, cause having wasted in the preparation process effective ingredient of many medicines, caused the waste of drug resource.

Summary of the invention

The objective of the invention is to the deficiency that exists in the existing cough suppressing medicine, a kind of pharmaceutical composition with effect of relieving cough and resolving phlegm, heat-clearing and toxic substances removing, relieving cough and asthma is provided, said composition also can be used for preparing diseases such as cardiopalmus that the treatment cough and asthma causes, insomnia, is specially adapted to treat children's's diseases such as heating, cough, expectorant Huang.

Another object of the present invention is to provide the preparation method of aforementioned pharmaceutical compositions, this method is simple to operate, is convenient to implement, and medicine recovery rate height has farthest kept the effective ingredient of medicine.

The object of the invention is achieved by following scheme:

The effective ingredient in Chinese compositions of treatment cough of the present invention is made up of following components in part by mass: Folium Eriobotryae 50 ~ 100, Radix et Rhizoma Dysosmatis 1 ~ 10, Fructus Mori 1 ~ 25, Herba Violae japonicae 1 ~ 5.

Wherein, said composition is preferably by following components in part by mass forms: Folium Eriobotryae 60 ~ 80, Radix et Rhizoma Dysosmatis 4 ~ 8, Fructus Mori 7 ~ 20, Herba Violae japonicae 2 ~ 4.

Said composition most preferably is by following components in part by mass to be formed: Folium Eriobotryae 75, Radix et Rhizoma Dysosmatis 6, Fructus Mori 18, Herba Violae japonicae 3.

The preparation method step of above-mentioned composition is as follows:

(1) gets Folium Eriobotryae, Radix et Rhizoma Dysosmatis, Fructus Mori and Herba Violae japonicae, decoct with water, decocting liquid is filtered, concentrate, precipitate with ethanol, reconcentration, obtain concentrated solution;

(2) get above-mentioned concentrated solution, preparation process adds proper auxiliary materials routinely, is processed into corresponding dosage form.

Wherein, the preparation method of said composition is preferably:

(1) gets Folium Eriobotryae, Radix et Rhizoma Dysosmatis, Fructus Mori and Herba Violae japonicae, be ground into coarse powder, add 8 ~ 12 times of water gagings and decoct each 1 ~ 2 hour 1 ~ 3 time, decocting liquid filters, filtrate merges, and is evaporated to relative density and is 1.10 ~ 1.15 clear paste, adds ethanol and makes that to contain the alcohol amount be 65%, left standstill 24 hours, filter, reclaim ethanol, concentrate, obtain concentrated solution;

(2) get above-mentioned concentrated solution, preparation process adds proper auxiliary materials routinely, is processed into corresponding dosage form.

The preparation method of said composition most preferably is:

(1) gets Folium Eriobotryae, Radix et Rhizoma Dysosmatis, Fructus Mori and Herba Violae japonicae, be ground into coarse powder, add 10 times of water gagings and decoct each 1.5 hours 2 times, decocting liquid filters, filtrate merges, and is evaporated to relative density and is 1.10 ~ 1.15 clear paste, adds ethanol and makes that to contain the alcohol amount be 65%, left standstill 24 hours, filter, reclaim ethanol, concentrate, obtain concentrated solution;

(2) get above-mentioned concentrated solution, preparation process adds proper auxiliary materials routinely, is processed into corresponding dosage form.

The compositions that contains Folium Eriobotryae by above-mentioned prescription and preparation method gained has following curative effect:

(1) mainly go into that taste are double goes into lung, the water of manage it wets, lowering the adverse flow of QI, and the damp-phlegm in can dispel taste and the lung, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass is violated on the inhibition damp-phlegm;

(2) diseases such as treatment fever of children, expectorant Huang, cough can not injure children's's internal organs;

(3) that diseases such as treatment cough, heating cause is dizzy, cardiopalmus, insomnia.

Compared with prior art, the present composition has following technique effect:

Present composition compatibility novelty is used for the treatment of the cough heating and waits the disease curative effect fast, and effect is obvious, takes simply, and dosage is few, has no side effect.

The specific embodiment

Below just embodiment further explain the present invention, but embodiment does not do any qualification to the present invention.

Embodiment 1

Get Folium Eriobotryae, Radix et Rhizoma Dysosmatis, Fructus Mori and Herba Violae japonicae, the consumption such as the table 1 of each component are ground into coarse powder with above-mentioned raw materials, add 8 times of water gagings and decoct 1.5 hours, filtering liquid medicine, be evaporated to relative density and be 1.13 clear paste, add ethanol and make that to contain the alcohol amount be 65%, standing over night, filter, reclaim ethanol, concentrate, obtain concentrated solution 1000ml.Get simple syrup, add above-mentioned concentrated solution, and transfer pH to 3.5 with citric acid, adding distil water stirs to 10000ml, is sub-packed in behind the fine straining in the 10ml vial, and packing promptly.

This product is the yellowish-brown clear liquid, places in half a year and must not produce muddiness.PH3 ~ 4, total solid 10 ~ 15%.

Embodiment 2

1. clinical observation 500 routine patients all have obvious clinical symptoms, and make a definite diagnosis through the clinicist.Wherein the oldest 70 years old, minimum eight months, the course of disease is the longest 6 years, and was the shortest 3 days.

2. the patient by age is divided into child's group (below 16 years old), adult group (17 ~ 55 years old), old group (more than 55 years old).The liquid that contains the Folium Eriobotryae compositions that obtains among the oral embodiment 1, the adult measures every day three times, each 10 ~ 20ml, and be contrast with the compound recipe CHUANBEI PIPA GAO, the oral administered compound CHUANBEI PIPA GAO, the adult measures every day three times, each 10ml.

3. cure: cough, asthma disappear substantially, and functional rehabilitation is normal.Produce effects: symptom is clearly better, and cough, asthma obviously reduce.Take a turn for the better: sx, cough reduces, and asthma alleviates.Invalid: symptom does not have change before and after the medication.

4. each age group is taken the liquid of the compositions that contains Folium Eriobotryae and is taken the therapeutic effect such as the table 2 of compound recipe CHUANBEI PIPA GAO.

By table 2 as can be known, the compositions that contains Folium Eriobotryae that embodiment 1 obtains has specially good effect in treatment cough heating, and is better than the compound recipe CHUANBEI PIPA GAO, and curative effect is particularly evident in the treatment children cough.In addition, the patient of treatment group is after medication, and sleep state all has remarkable improvement, and the disease that is accompanied by the patient of dizzy, cardio palmus shape also alleviates to some extent.

Embodiment 3

1. laboratory animal: ICR mice, body weight 23.5 ~ 25.5g, male and female half and half.

2. experimental technique: through prerun, the toxicity of the compositions that contains Folium Eriobotryae that obtains among the embodiment 1 is very low, can not survey LD50, measures so mice is carried out maximum dosage-feeding on the one.Maximum dosage-feeding is 200ml, is 20 times of adult's clinical oral administration dosage, observes none example after 7 days and is poisoned to death, all healthy survival.

Table 1 prescription consumption

Table 2 clinical observation on the therapeutic effect result

Claims (7)

1. Chinese medicine composition for the treatment of cough is characterized in that said composition is made up of following components in part by mass: Folium Eriobotryae 50～100, Radix et Rhizoma Dysosmatis 1～10, Fructus Mori 1～25, Herba Violae japonicae 1～5.

2. compositions as claimed in claim 1 is characterized in that said composition is made up of following components in part by mass: Folium Eriobotryae 60～80, Radix et Rhizoma Dysosmatis 4～8, Fructus Mori 7～20, Herba Violae japonicae 1～4.

3. compositions as claimed in claim 2 is characterized in that said composition is made up of following components in part by mass: Folium Eriobotryae 75, Radix et Rhizoma Dysosmatis 6, Fructus Mori 18, Herba Violae japonicae 3.

4. as any described compositions of claim in the claim 1～3, be processed into granule, tablet, oral liquid, syrup, capsule.

5. the described preparation of compositions method of claim 4 is characterized in that comprising the steps:

(1) gets Folium Eriobotryae, Radix et Rhizoma Dysosmatis, Fructus Mori and Herba Violae japonicae, decoct with water, decocting liquid is filtered, concentrate, precipitate with ethanol, reconcentration, obtain concentrated solution;

(2) get above-mentioned concentrated solution, preparation process adds proper auxiliary materials routinely, is processed into corresponding dosage form.

6. as preparation of compositions method as described in the claim 5, it is characterized in that comprising the steps:

(1) gets Folium Eriobotryae, Radix et Rhizoma Dysosmatis, Fructus Mori and Herba Violae japonicae, be ground into coarse powder, add 8～12 times of water gagings and decoct each 1～2 hour 1～3 time, decocting liquid filters, filtrate merges, and is evaporated to relative density and is 1.10～1.15 clear paste, adds ethanol and makes that to contain the alcohol amount be 65%, left standstill 24 hours, filter, reclaim ethanol, concentrate, obtain concentrated solution;

(2) get above-mentioned concentrated solution, preparation process adds proper auxiliary materials routinely, is processed into corresponding dosage form.

7. as preparation of compositions method as described in the claim 6, it is characterized in that comprising the steps:

(1) gets Folium Eriobotryae, Radix et Rhizoma Dysosmatis, Fructus Mori and Herba Violae japonicae, be ground into coarse powder, add 10 times of water gagings and decoct each 1.5 hours 2 times, decocting liquid filters, filtrate merges, and is evaporated to relative density and is 1.10～1.15 clear paste, adds ethanol and makes that to contain the alcohol amount be 65%, left standstill 24 hours, filter, reclaim ethanol, concentrate, obtain concentrated solution;

(2) get above-mentioned concentrated solution, preparation process adds proper auxiliary materials routinely, is processed into corresponding dosage form.