CN101797295B - Medicinal composition for treating infantile cough and preparation method thereof - Google Patents
Medicinal composition for treating infantile cough and preparation method thereof Download PDFInfo
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- CN101797295B CN101797295B CN2010101425284A CN201010142528A CN101797295B CN 101797295 B CN101797295 B CN 101797295B CN 2010101425284 A CN2010101425284 A CN 2010101425284A CN 201010142528 A CN201010142528 A CN 201010142528A CN 101797295 B CN101797295 B CN 101797295B
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Abstract
The invention relates to a medicinal composition for treating infantile cough, which is a preparation prepared from the following raw materials of divaricate saposhnikovia root, liquorice, dried orange peel, balloon flower, folium perillae, peucedanum root, apricot and radix scutellariae. The medicinal composition has reasonable formula and defined curative effect, and can be used for effectively treating the infantile cough.
Description
Technical field
The present invention relates to field of medicaments, specifically, relate to a kind of pharmaceutical composition for the treatment of infantile cough and preparation method thereof.
Background technology
Infantile cough is the common multiple symptom of department of pediatrics respiratory tract, and it is the respiratory tract common disease that multiple reason causes, all can fall ill throughout the year.Along with growth in the living standard, improper feeding, father and mother pamper, and it is blocked up to wear the clothes, and eating and drinking without temperance is raw and cold, greasy; Children's can cause all that with the edible tonic of the head of a family, delicious food savoury etc. cough shows effect repeatedly.How general cough can fully recover through treating, but the age is immature, body is frail, cough is serious or the permanent person of the course of disease, uses antibiotic, damage to the child is very big, uses repeatedly to be easy to generate drug resistance, the lighter's impairing the spleen and stomach again, weight person causes lesions of liver and kidney, has endless trouble.Diseases such as moreover many children are poorer with the antibiotic resistance, catch a cold repeatedly, tracheitis, pneumonia cause antibiotic more with more upgrading, and it is potential very harmful.
The patent of relevant at present treatment infantile cough is as follows: patent documentation CN101564517 discloses a kind of Chinese medicine and preparation thereof for the treatment of children cough and asthma, and it is formed with Bulbus Fritillariae Cirrhosae, Radix Platycodonis, Radix Stemonae, Radix Glehniae, Flos Farfarae, Radix Asteris, Radix Ophiopogonis, Pheretima, Rhizoma Imperatae, Rhizoma Arisaematis (processed), Rhizoma Phragmitis, Radix Gentianae, the Rhizoma Anemarrhenae, the Pseudobulbus Bletillae (Rhizoma Bletillae); Said medicine can be made said dosage form on any pharmaceutics by the certain part by weight proportioning.Patent documentation CN1947779 discloses a kind of Chinese medicinal granule preparation that is used for the treatment of infantile cough and preparation method thereof, it contains compositions such as Folium Perillae, Flos Chrysanthemi, Radix Puerariae, Bulbus Fritillariae Cirrhosae, Semen Armeniacae Amarum, Folium Eriobotryae, has clearing away heat and expelling pathogen in the exterior, the effect of relieving cough and resolving phlegm, be used for the interior-heat lung-fire, the fever of the body cough that affection due to external wind and heat causes, tachypnea abundant expectoration, irritated thirsty, disease such as be hard and dry.Patent documentation CN101036719 discloses a kind of syrup for the treatment of infantile cough and preparation method thereof, and it is made by Radix Glycyrrhizae fluidextract 50-400ML, Radix Platycodonis fluidextract 10-60ML, ammonium chloride 2-20G, Pericarpium Citri junoris tincture 10-40ML and sucrose 200-500G, sodium benzoate 3-7G.This syrup not only have better eliminate the phlegm, the antitussive effect, the cough that infantile common cold is caused has definite curative effect, and reduced the content of sucrose in the preparation, it is sweet excessively to have solved the XIAOER ZHIKE TANGJIANG mouthfeel, insufferable situation when part patient takes, convenient children taking, the child's epinephrine level that can avoid simultaneously causing because of the sucrose amount is too high increases, thereby cause anxiety, absent minded, make the generation of situations such as child's tetchiness.Patent documentation CN101433555 discloses a kind of Chinese medicine for the treatment of infantile cough, and it is made by the following weight proportion raw material: Fel Gallus domesticus 8-15, Cinnabaris 1-10, Borneolum Syntheticum 0.7-1.5, Gypsum Fibrosum 8-13.Getting freshly-slaughtered poultry bile packs in the high temperature bottle, be placed on and boil taking-up in 30 minutes in the pot, with Gypsum Fibrosum, Borneolum Syntheticum, Cinnabaris is smalls by the pulverizer mill respectively, by 120 mesh sieves sieve down, get Fel Gallus domesticus and Gypsum Fibrosum is mixed thoroughly by top described proportioning, take out after being placed on drying in oven, add Cinnabaris and borneol powder by described proportioning then, mix homogeneously is made medicated powder.。Do not see at present the relevant report of traditional Chinese medicine composition for treating infantile cough of the present invention.
Summary of the invention
The purpose of this invention is to provide a kind of pharmaceutical composition for the treatment of infantile cough.
The present invention also aims to provide the preparation of drug combination method of this treatment infantile cough.
In order to realize purpose of the present invention, the invention provides a kind of pharmaceutical composition for the treatment of infantile diarrhea, it is the medicament of being made by weight by following bulk drugs:
1~10 part of 1~5 part of Radix Platycodonis of 1~5 part of Pericarpium Citri Reticulatae of 1~10 portion of Radix Glycyrrhizae of Radix Saposhnikoviae
1~10 part of 1~10 part of Radix Scutellariae of 1~5 part of Semen Armeniacae Amarum of 1~10 part of Radix Peucedani of Folium Perillae.
Preferably, it is the medicament of being made by weight by following bulk drugs:
5 parts of 4 parts of Radix Platycodoniss of 3 parts of Pericarpium Citri Reticulataes of 5 portions of Radix Glycyrrhizaes of Radix Saposhnikoviae
10 parts of 5 parts of Radix Scutellariaes of 5 parts of Semen Armeniacae Amarums of 6 parts of Radix Peucedanis of Folium Perillae.
Pharmaceutical composition of the present invention can be made various dosage forms with pharmaceutically acceptable carrier, such as tablet, capsule, soft capsule, pill, granule, oral liquid or decoction etc.Can adopt preparation technique means well known in the art to finish preparation of drug combination of the present invention.
Described pharmaceutically acceptable carrier is well known, for being used to prepare the usual excipients or the adjuvant of above-mentioned preparation.Excipient or adjuvant commonly used comprise (but being not limited to) filler, lubricant, dispersant, wetting agent, binding agent, antioxidant or the like, for example, syrup, arabic gum, sorbitol, lactose, dextrin, starch, calcium carbonate, Pulvis Talci, Polyethylene Glycol, carboxymethyl starch sodium, magnesium stearate or the like.
The present invention also provides a kind of preparation of drug combination method for the treatment of infantile cough, and this method comprises:
1) following raw medicines in parts by weight is mixed:
1~10 part of 1~5 part of Radix Platycodonis of 1~5 part of Pericarpium Citri Reticulatae of 1~10 portion of Radix Glycyrrhizae of Radix Saposhnikoviae
1~10 part of 1~10 part of Radix Scutellariae of 1~5 part of Semen Armeniacae Amarum of 1~10 part of Radix Peucedani of Folium Perillae;
2) water of 8-12 times of crude drug weight of adding, 100 ℃ decoct 2-3 time, and each 2-3 hour, filter, merging filtrate, it is 1.25-1.3 (50 ℃) thick paste that filtrate is concentrated into relative density, adds pharmaceutically acceptable carrier again, makes various dosage forms.
In addition, the present invention also provides a kind of preparation method for the treatment of the oral liquid of infantile cough, and this method comprises:
1) following bulk drugs is mixed:
Radix Saposhnikoviae 500 gram Radix Glycyrrhizaes 300 gram Pericarpium Citri Reticulataes 400 gram Radix Platycodoniss 500 grams
Folium Perillae 600 gram Radix Peucedanis 500 gram Semen Armeniacae Amarums 500 gram Radix Scutellariaes 1000 grams;
2) water of 9 times of crude drug weight of adding, 70 ℃ were heated 2 hours, filtered, and filtrate decompression is concentrated into 2000ml, high speed centrifugation, filtering with microporous membrane, in embedding to 100 bottle, sterilization is promptly.
The reasonable recipe of pharmaceutical composition of the present invention, curative effect is clear and definite, can treat infantile cough effectively.
The specific embodiment
Below the invention will be further described for the description by the specific embodiment, but this is not to be limitation of the present invention, those skilled in the art are according to basic thought of the present invention, can make various modifications or improvement, but only otherwise break away from basic thought of the present invention, all within the scope of the present invention.
The preparation of embodiment 1 medicament composition capsule agent of the present invention
Take by weighing Radix Saposhnikoviae 500 grams, Radix Glycyrrhizae 300 grams, Pericarpium Citri Reticulatae 400 grams, Radix Platycodonis 500 grams, Folium Perillae 600 grams, Radix Peucedani 500 grams, Semen Armeniacae Amarum 500 grams, Radix Scutellariae 1000 grams.Be cut into coarse grain and add 12 times of amounts of water, 100 ℃ were heated 2 hours, filtered, and collected filtrate; Medicinal residues add 8 times of amounts of water, and 100 ℃ were heated 3 hours, filtered, and collected filtrate.Merge filtrate twice, filtrate decompression is concentrated into the thick paste of relative density about 1.25 (50 ℃), once finish spray drying, promptly encapsulated.
The preparation of embodiment 2 drug composition oral liquid of the present invention
Take by weighing Radix Saposhnikoviae 500 grams, Radix Glycyrrhizae 300 grams, Pericarpium Citri Reticulatae 400 grams, Radix Platycodonis 500 grams, Folium Perillae 600 grams, Radix Peucedani 500 grams, Semen Armeniacae Amarum 500 grams, Radix Scutellariae 1000 grams.The water that adds 9 times of crude drug weight, 70 ℃ were heated 2 hours, filtered, and filtrate decompression is concentrated into 2000ml, high speed centrifugation, filtering with microporous membrane, in embedding to 100 bottle, sterilization is promptly.
Experimental example
Diagnostic criteria:
According to " disease of tcm diagnosis criterion of therapeutical effect " (Nanjing: publishing house of Nanjing University, 1994) and " pediatrics (the 6th edition, the People's Health Publisher publishes, 2003) determine the diagnostic criteria that infant is coughed: infant all is main clinical manifestation with the cough, companion or do not occur together heat, watery nasal discharge, headache, pharyngalgia etc., two lungs or audible and dried or moist rale.Close case 60 examples of the standard of stating of selector, male's 30 examples wherein, 2 years old mean age, women's 30 examples, 2.2 years old mean age.
Therapeutic scheme
Observed infant is divided into two groups at random: treatment group (using the oral liquid described in the embodiment 2) 30 examples, matched group (using XIAOER ZHIKE TANGJIANG) 30 examples available from Yaan three nine-day periods after the winter solstice Pharmaceutical.Two groups of cases are learned by statistics and are handled equal no significant difference at aspects such as sex, age, the course of disease, the distributions of sick kind.
Method of administration
Treatment group: the oral liquid described in the oral embodiment 2, one day twice, each one bottle.
Matched group: oral XIAOER ZHIKE TANGJIANG, one day twice, each 5ml.
Efficacy assessment standard
Determine that according to " disease of tcm diagnosis criterion of therapeutical effect " (Nanjing: publishing house of Nanjing University, 1994) the therapeutic evaluation standard is as follows.Produce effects: transference cures such as cough, heating, watery nasal discharge, headache, pharyngalgia, hemogram, chest film inspection are normal.Effectively: clinical symptom relief, hemogram, chest film inspection take a turn for the better.Invalid: clinical symptoms does not have obvious change or increases the weight of.
Therapeutic outcome:
Treatment group: produce effects 22 examples, effective 8 examples, total effective rate 100%;
Treatment group: produce effects 12 examples, effective 15 examples, invalid 3 examples, total effective rate 90%.
Two groups relatively have significant difference, illustrate that the therapeutic effect of treatment group is better than the therapeutic effect of matched group.
Untoward reaction
After taking two groups of medicines, all do not find tangible untoward reaction.
Claims (3)
1. a pharmaceutical composition for the treatment of infantile cough is characterized in that, it is the medicament of being made by weight by following bulk drugs:
1~10 part of 1~5 part of Radix Platycodonis of 1~5 part of Pericarpium Citri Reticulatae of 1~10 portion of Radix Glycyrrhizae of Radix Saposhnikoviae
1~10 part of 1~10 part of Radix Scutellariae of 1~5 part of Semen Armeniacae Amarum of 1~10 part of Radix Peucedani of Folium Perillae.
2. the pharmaceutical composition of treatment infantile cough according to claim 1 is characterized in that, it is the medicament of being made by weight by following bulk drugs:
5 parts of 4 parts of Radix Platycodoniss of 3 parts of Pericarpium Citri Reticulataes of 5 portions of Radix Glycyrrhizaes of Radix Saposhnikoviae
10 parts of 5 parts of Radix Scutellariaes of 5 parts of Semen Armeniacae Amarums of 6 parts of Radix Peucedanis of Folium Perillae.
3. preparation method for the treatment of the oral liquid of infantile cough, this method comprises:
1) following bulk drugs is mixed:
Radix Saposhnikoviae 500 gram Radix Glycyrrhizaes 300 gram Pericarpium Citri Reticulataes 400 gram Radix Platycodoniss 500 grams
Folium Perillae 600 gram Radix Peucedanis 500 gram Semen Armeniacae Amarums 500 gram Radix Scutellariaes 1000 grams;
2) water of 9 times of crude drug weight of adding, 70 ℃ were heated 2 hours, filtered, and filtrate decompression is concentrated into 2000ml, high speed centrifugation, filtering with microporous membrane, in embedding to 100 bottle, sterilization is promptly.
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CN101797295B true CN101797295B (en) | 2011-07-27 |
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Families Citing this family (4)
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CN102657721A (en) * | 2012-04-16 | 2012-09-12 | 杭州天诚药业有限公司 | Cold granule and preparation method thereof |
CN104510957A (en) * | 2014-12-23 | 2015-04-15 | 蓝蓉蓉 | Traditional Chinese medicament for treating pertussis of children and preparation method for traditional Chinese medicament |
CN104643315B (en) * | 2015-01-23 | 2016-01-20 | 山东大学 | A kind of gauze mask and preparation method |
CN109224016A (en) * | 2018-11-27 | 2019-01-18 | 何雁玲 | A kind of relieving cough and reducing sputum cream of external application and preparation method thereof |
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CN1824097A (en) * | 2005-12-27 | 2006-08-30 | 广西桂西制药有限公司 | Chinese medicinal preparation for treating cough and its preparation method |
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CN1824097A (en) * | 2005-12-27 | 2006-08-30 | 广西桂西制药有限公司 | Chinese medicinal preparation for treating cough and its preparation method |
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