WO2017206016A1 - Anti-inflammation and swelling-relief traditional chinese ointment for external application - Google Patents

Abstract

A traditional Chinese ointment for external application for anti-inflammation and swelling relief, consisting of the following components in parts by weight: 15-20 parts of seeds of Fructus hippophae, 10-15 parts of Cortex phellodendri, 8-12 parts of Radix rehmanniae, 8-12 parts of Cota tinctoria, 5-15 parts of Fructus forsythiae, 5-15 parts of Ramulus uncariae cum uncis, 5-10 parts of pumpkin seed, 3-7 parts of Ligusticum chuanxiong, 3-5 parts of VB₅, and 3-5 parts of transdermal enhancer. The transdermal enhancer comprises 30-40 wt% of menthol, 30-40 wt% of Borneolum syntheticum, 15-20 wt% of PEG, and 10-15 wt% of octanol.

Description

External application of anti-inflammatory and swelling Chinese medicine ointment Technical field

The invention relates to a traditional Chinese medicine ointment. More specifically, the present invention relates to a traditional Chinese medicine ointment having an external application of anti-inflammatory and swelling.

Background technique

The external Chinese medicine ointment is an external semi-solid dosage form which is easily mixed on the skin surface and is prepared by mixing the medicinal material extract with a suitable medium, and has the advantages of good adhesion, spreadability, convenient use and the like. TCM external application ointment uses the synergistic effect of drugs to form a large compound of multi-flavor drugs, in order to exert the good effect of the drug, the traditional Chinese medicine ointment is applied to the surface of the plaster to stimulate the nerve endings, through the reflection, dilation of blood vessels, and promotion of local blood Circulation, improve the nutrition of the surrounding tissues, so as to achieve the purpose of swelling, anti-inflammatory and analgesic. At the same time, the drug penetrates the subcutaneous tissue through the skin in the affected area, and the relative advantage of the drug concentration is locally generated, thereby exerting a strong pharmacological effect.

However, the traditional external application of anti-inflammatory and swelling Chinese medicine ointment has the following disadvantages: (1) Only the efficacy of traditional Chinese medicine is considered when formulating the ointment, but its toxicity and irritation are neglected, which may aggravate the discomfort of the patient; (2) the traditional external application of ointment The transdermal absorption effect is poor, and the ideal therapeutic effect is not achieved; (3) The traditional Chinese medicine ointment mostly uses sesame oil to extract the traditional Chinese medicine component, and it is easy to extract the active ingredient or the active ingredient in the medicinal material due to the excessive temperature.

Summary of the invention

As a result of various extensive and meticulous research and experiments, the inventors of the present invention have found that by properly combining nine kinds of Chinese herbal medicines, they are non-irritating to the skin, and are processed according to the characteristics of each Chinese herbal medicine and the extraction of active ingredients. In addition, a transdermal enhancer composed of a suitable ratio of menthol, borneol, PEG, and octanol is also added to the traditional Chinese medicine ointment of the present invention, which significantly increases the therapeutic effect of the traditional Chinese medicine external application ointment. Based on this finding, the present invention has been completed.

It is an object of the present invention to address at least the above problems and/or disadvantages and to provide at least The advantages of Ming.

Still another object of the present invention is to provide an external application of an anti-inflammatory and swelling traditional Chinese medicine ointment, which can quickly reduce inflammation and reduce swelling, has remarkable curative effect, is convenient to use, and is non-irritating to the skin.

In order to achieve these and other advantages in accordance with the present invention, there is provided an externally applied anti-inflammatory and anti-inflammatory Chinese medicine ointment comprising, by weight, consisting of the following grouping ratios:

In the above traditional Chinese medicine ointment formula, sea buckthorn core, cork, raw land, chamomile flower, forsythia, uncaria, pumpkin seed, Chuanxiong and VB ₅ can produce strong and long-lasting heat-clearing, anti-inflammatory and swelling-reducing effects. Seabuckthorn oil in seabuckthorn fruit nucleus can resist anti-inflammatory muscles and promote tissue regeneration. Phellodendron has strong inhibitory effect on various pathogenic bacteria, and has astringent and anti-inflammatory effects. The habitat can be used for stagnation of blood circulation and blood circulation. Huayu Chrysanthemum has excellent anti-inflammatory and anti-inflammatory effects, relieves pain and swelling, promotes wound healing, and promotes cell regeneration and skin metabolism. Forsythia treats heat-clearing and detoxifying, swelling and dispersing; Uncaria can be used for Shujinhuo It can reduce swelling and analgesia; pumpkin seeds have anti-inflammatory and analgesic effects; Chuanxiong can be used for activating blood circulation and phlegm and relieving pain; proper addition of VB ₅ can be used to soothe the skin and promote the recovery of skin health.

Preferably, wherein, by weight, it consists of the following group distribution ratios:

Preferably, the transdermal enhancer comprises 30-40% by weight of menthol, 30-40% by weight of borneol, 15-20% by weight of PEG and 10-15% by weight of octanol. The addition of menthol can change the permeability of the stratum corneum, reduce the resistance of the drug to penetration through the skin, and improve the diffusion system of the drug in the stratum corneum of the skin. The borneol can synergize with menthol to effectively increase the absorption of the drug by the skin; PEG and octanol can fuse and mix traditional Chinese medicine with menthol and borneol, which not only increases the solubility of the drug, but also significantly improves the long-term effect of the penetration-promoting effect.

Preferably, the molecular weight of the PEG is 400-600. Under this molecular weight, the PEG has good compatibility with drugs and other excipients, and has an optimal promoting effect on the transdermal efficiency of the drug.

Preferably, the sea buckthorn core, the yellow cedar, the raw land, the hook vine, the chuanxiong, respectively, are pulverized, mixed, and then extracted with 85% ethanol as a solvent at 80 ° C for 3 times to promote the dissolution of the active ingredient of the traditional Chinese medicine. .

Preferably, the chamomile flower, forsythia, and pumpkin seeds are respectively pulverized, mixed, and then extracted with 70% ethanol as a solvent at 55 to 60 ° C for 2 times, chamomile flowers, forsythia and pumpkin. The ethanol reflux extraction temperature of the child should not be too high, otherwise it will increase the dissolution of the ineffective components and reduce the efficacy.

Preferably, the sea buckthorn core, the yellow cedar, the raw land, the genus Uncaria, and the Chuanxiong are respectively pulverized to 20 to 25 μm, thereby ensuring the leaching of the active ingredient of the traditional Chinese medicine and preventing the fine particle size of the traditional Chinese medicine from affecting the filtration.

Preferably, the 85% ethanol is 5-8 times of the mixed volume of Hippophae rhamnoides, Cork, S. chinensis, Uncaria and Chuanxiong, and the time of each extraction is 1-2 h, suitable ratio of material to liquid and extraction time Ensure the mass transfer driving force and increase the extraction rate of effective substances.

Preferably, the chamomile flower, forsythia, and pumpkin seed are respectively pulverized to 28 to 32 μm, so that the active ingredient of the traditional Chinese medicine can be sufficiently dissolved to ensure a balance between the dissolution rate of the active ingredient and the pulverization energy.

Preferably, in each extraction, the 70% ethanol is 4-5 times of the chamomile flower, forsythia and pumpkin seeds, and the time of each extraction is 0.3-0.7 h to ensure the active ingredient of the traditional Chinese medicine. Dissolution Outlet rate and dissolution stability between batches.

The invention includes at least the following beneficial effects:

(1) In the formula of the traditional Chinese medicine ointment, the combination of sea buckthorn core, cork, raw land, chamomile flower, forsythia, uncaria, pumpkin seed and Chuanxiong can produce strong and long-lasting heat-clearing, anti-inflammatory and swelling effect, and the effect is mild. Not irritating to the skin;

(2) The use of a transdermal enhancer consisting of a suitable ratio of menthol, borneol, PEG and octanol in the present invention effectively changes the permeability of the stratum corneum of the skin, reduces the resistance of the drug to penetration through the skin, and improves the drug in The diffusion system of the stratum corneum of the skin, and the prolongation effect is long-lasting;

(3) The present invention replaces the traditional sesame oil extraction method, and adopts different alcohol reflux processes for extraction according to different properties of the Chinese herbal medicine, thereby ensuring sufficient extraction of the active ingredients and avoiding excessive impurities of the traditional Chinese medicine paste caused by excessive extraction temperature. Poor efficacy.

Other advantages, objects, and features of the invention will be set forth in part in the description in the description which

detailed description

The present invention will be further described in detail below with reference to specific embodiments, so that those skilled in the art can refer to the description.

It is to be understood that the terms "having", "comprising" and "comprising" are used in the <RTIgt;

<Example 1>

An external application of anti-inflammatory and swelling traditional Chinese medicine ointment, which comprises, by weight, by the following group distribution ratio: 15 parts of sea buckthorn core; 10 parts of Phellodendron; 8 parts of habitat; 8 parts of chamomile flower; 5 parts of forsythia; Parts; 5 parts of pumpkin seeds; 3 parts of Chuanxiong; 3 parts of VB ₅ ; 3 parts of transdermal enhancer.

Wherein, the transdermal enhancer comprises 30% by weight of menthol, 40% by weight of borneol, 20% by weight of PEG400 and 10% by weight of octanol.

Wherein, the seabuckthorn core, the yellow cedar, the raw land, the genus Uncaria, and the Chuanxiong are respectively pulverized to an average particle diameter of 20 μm, mixed, and then 8 times of ethanol of the Chinese medicine mixture is used as a solvent, and the mixture is refluxed at 80 ° C for 3 times. The first time, each extraction is 1h; the chamomile flowers, forsythia, and pumpkin seeds are respectively pulverized to 28 μm, mixed, and then sequentially mixed with 4 times of chrysanthemum, forsythia and pumpkin seeds. 70% ethanol was used as a solvent, and the extraction was carried out twice at 55 ° C, and the extraction time was 0.3 h.

The traditional Chinese medicine ointment prepared in this example is applied to clinical treatment:

Zhang, male, 35 years old, due to the damp environment of the residence, a large piece of small sputum on the back, itching redness, external application of the traditional Chinese medicine ointment prepared in this example, the itching symptoms were effectively relieved, after 3 days, the sputum disappeared, no scar, and the effect was satisfactory.

<Example 2>

An external application of anti-inflammatory and swelling traditional Chinese medicine ointment, which comprises, by weight, by the following group distribution ratio: 20 parts of sea buckthorn core; 15 parts of Phellodendron; 12 parts of habitat; 12 parts of chamomile flower; 15 parts of forsythia; Parts; 10 parts of pumpkin seeds; 7 parts of Chuanxiong; 5 parts of VB ₅ ; 5 parts of transdermal enhancer.

Wherein, the transdermal enhancer comprises 40% by weight of menthol, 35% by weight of borneol, 15% by weight of PEG600 and 10% by weight of octanol.

Wherein, the seabuckthorn core, the yellow cedar, the raw land, the genus Uncaria, and the Chuanxiong are respectively pulverized to an average particle diameter of 25 μm, mixed, and then 8 times of ethanol of 8 times of the Chinese medicine mixture is used as a solvent, and refluxed at 80 ° C for 3 times. Times, each extraction time is 2h. The chamomile flower, forsythia, and pumpkin seeds are respectively pulverized to 32 μm, mixed, and then sequentially mixed with 70% ethanol of 5 times chamomile, forsythia and pumpkin seed volume, and refluxed at 60 ° C. 2 times, the time of each extraction is 0.7h.

The traditional Chinese medicine ointment prepared in this example is applied to clinical treatment:

Liu, female, 67 years old, due to cerebral infarction, hemiplegia for half a year, lying in bed for a long time, the skin of the appendix is formed into a faint erythema, and the traditional Chinese medicine ointment prepared by this example is applied, and the measures of turning over and decompressing are taken at the same time. It has a refreshing sensation and is non-irritating, and the erythema gradually disappears and is cured after 7 days.

<Example 3>

External application of anti-inflammatory and swelling traditional Chinese medicine ointment, which comprises, by weight, by the following group distribution ratio: 16 parts of sea buckthorn kernel; 12 parts of Phellodendron; 11 parts of habitat; 12 parts of chamomile flower; 7 parts of forsythia; Servings; 9 parts of pumpkin seeds; 3 parts of Chuanxiong; 5 parts of VB ₅ ; 4 parts of transdermal enhancer.

Wherein, the transdermal enhancer comprises 35 wt% menthol, 35 wt% borneol, 15 wt% PEG 500, and 15 wt% octanol.

Wherein, the seabuckthorn core, the yellow cedar, the raw land, the genus Uncaria, and the Chuanxiong are respectively pulverized to an average particle diameter of 23 μm, mixed, and then 8 times of ethanol of the Chinese medicine mixture is used as a solvent, and the co-extraction is carried out at 80 ° C under reflux. The extraction time is 2h, 1.5h and 1h respectively; the chamomile flower, forsythia, The pumpkin seeds were pulverized to 30 μm, mixed, and then, with 4.5 times the volume of chamomile, forsythia and pumpkin seeds, 70% ethanol as solvent, and refluxed at 58 ° C for 2 times, the extraction time was 0.5 h and 0.7h.

The traditional Chinese medicine ointment prepared in this example is applied to clinical treatment:

Chen, male, 8 years old, suffering from flaky redness and swelling, and itching sensation, external application of the traditional Chinese medicine ointment prepared in this example, the itching symptoms were effectively relieved, redness disappeared after 3 days, the effect was satisfactory.

<Example 4>

External application of anti-inflammatory and swelling traditional Chinese medicine ointment, which comprises, by weight, by the following group distribution ratio: 18 parts of seabuckthorn fruit core; 14 parts of Phellodendron; 10 parts of habitat; 9 parts of chamomile flower; 12 parts of forsythia; parts; 7 parts by pumpkin seeds; Chuanxiong 5 parts; VB ₅ parts of 4; 4 parts penetration enhancer.

Wherein, the transdermal enhancer comprises 32% by weight of menthol, 38% by weight of borneol, 18% by weight of PEG400 and 12% by weight of octanol.

Wherein, the seabuckthorn core, the yellow cedar, the raw land, the genus Uncaria, and the Chuanxiong are respectively pulverized to an average particle diameter of 22 μm, mixed, and then 8 times of ethanol of 8 times of the Chinese medicine mixture is used as a solvent, and refluxed at 80 ° C for 3 times. The extraction time was 1.5h, 1.5h and 1h respectively; the chamomile flowers, forsythia and pumpkin seeds were pulverized to 29μm, mixed, and then 4 times chamomile, forsythia and pumpkin mixture The volume of 70% ethanol was used as a solvent, and the extraction was carried out twice at 58 ° C, and the extraction time was 0.7 h and 0.4 h, respectively.

The traditional Chinese medicine ointment prepared in this example is applied to clinical treatment:

Li Mou, male, 24 years old, suffered from redness and swelling in the legs due to exercise and soft tissue. The traditional Chinese medicine ointment prepared in this example was completely disappeared after 5 days, and the curative effect was satisfactory.

<Example 5>

An external application of anti-inflammatory and swelling traditional Chinese medicine ointment, which comprises, by weight, by the following group distribution ratio: 17 parts of sea buckthorn kernel; 13 parts of cork; 9 parts of habitat; 11 parts of chamomile flower; 10 parts of forsythia; Servings; 8 parts of pumpkin seeds; 6 parts of Chuanxiong; 5 parts of VB ₅ ; 4 parts of transdermal enhancer.

Wherein, the transdermal enhancer comprises 36% by weight of menthol, 33% by weight of borneol, 17% by weight of PEG500 and 14% by weight of octanol.

Wherein, the seabuckthorn core, the yellow cypress, the raw land, the genus Uncaria, and the Chuanxiong are respectively pulverized to an average particle diameter After 24 μm, the mixture was mixed with 85% ethanol of 7 times Chinese herbal medicine as solvent, and refluxed at 80 ° C for 3 times. The extraction time was 1.5 h, 1 h and 2 h, respectively; the chamomile flower, forsythia, and pumpkin seeds were respectively After pulverizing to 31 μm, the mixture was mixed, and then 70 times of the volume of the mixture of chamomile flowers, forsythia and pumpkin seeds was used as a solvent, and the mixture was re-extracted twice at 59 ° C for 0.6 h and 0.5 h, respectively.

The traditional Chinese medicine ointment prepared in this example is applied to clinical treatment:

Xie Mou, female, 42 years old, her arm was bruised by a bee. After the bee sting was pulled out, there was redness and swelling. The traditional Chinese medicine ointment prepared in this example was used to relieve the pain symptoms. After 4 days, the redness disappeared without scars. .

It can be seen that the external application of anti-inflammatory and anti-inflammatory traditional Chinese medicine ointment prepared by the invention has rapid action, can produce strong and lasting anti-inflammatory and anti-inflammatory effect, and has mild effect and no irritation to skin.

Although the embodiments of the present invention have been disclosed as above, they are not limited to the applications listed in the specification and the embodiments. It can be applied to a wide variety of fields suitable for the present invention. Additional modifications can be readily implemented by those skilled in the art. The present invention is therefore not limited to the specific details and embodiments shown and described herein.

Claims (10)

1. An external application of anti-inflammatory and swelling traditional Chinese medicine ointment, characterized in that, by weight, it consists of the following group distribution ratios:

   
2. The external application anti-inflammatory and swelling traditional Chinese medicine ointment according to claim 1, which is composed of the following group distribution ratios by weight:

   
3. The external application anti-inflammatory and swelling traditional Chinese medicine ointment according to claim 1, wherein the transdermal enhancer comprises 30 to 40% by weight of menthol, 30 to 40% by weight of borneol, 15 to 20% by weight of PEG and 10 to 15% by weight. % octanol.
4. The external application anti-inflammatory and swelling traditional Chinese medicine ointment according to claim 3, wherein the PEG has a molecular weight of 400 to 600.
5. The externally applied anti-inflammatory and swelling traditional Chinese medicine ointment according to claim 1, wherein the sea buckthorn core, the yellow cedar, the raw land, the genus Uncaria, and the Chuanxiong are separately pulverized, mixed, and then 85% ethanol is used as a solvent, 80 ° C Extracted back to 3 times.
6. The external application anti-inflammatory and swelling traditional Chinese medicine ointment according to claim 1, wherein the chamomile flower, forsythia, and pumpkin are respectively pulverized, mixed, and then refluxed with 70% ethanol as a solvent at 55 to 60 ° C. Extract 2 times.
7. The externally applied anti-inflammatory and swelling traditional Chinese medicine ointment according to claim 5, wherein the sea buckthorn core, the yellow cedar, the raw land, the genus Uncaria, and the Chuanxiong are respectively pulverized to 20 to 25 μm.
8. The external application anti-inflammatory and swelling traditional Chinese medicine ointment according to claim 5, characterized in that, in each extraction, the 85% ethanol is 5-8 times of the mixed volume of sea buckthorn core, cork, raw land, Uncaria and Chuanxiong, each time The extraction time is 1 to 2 hours.
9. The externally applied anti-inflammatory and swelling traditional Chinese medicine ointment according to claim 6, wherein the chamomile flower, forsythia, and pumpkin are pulverized to 28 to 32 μm, respectively.
10. The external application anti-inflammatory and swelling traditional Chinese medicine ointment according to claim 6, wherein each 70% of the ethanol is 4 to 5 times of the mixed volume of the chamomile flower, forsythia and pumpkin seeds, each time The extraction time is 0.3 to 0.7 h.