DE202004018534U1 - Herbal composition for side-effect free treatment of depression, comprising herbs or herbal extracts for promoting blood flow and reducing coagulated blood levels, calming, sedation and flow of Qi - Google Patents

Abstract

A herbal composition (I) comprises herbs (or their extracts) for: (a) promoting blood flow and reducing coagulated blood levels; (b) calming; (c) sedation; and (d) flow of 'Qi'; where (a) is one of 15 specific herbs (e.g. Salvia multiorhiza), (b) is one of 9 specific herbs (e.g. Lilium brownii), (c) is one of 4 specific herbs (e.g. Rehmannia glutinosa) and (d) is one of 20 specific herbs (e.g. Citrus cinensis). A herbal composition (I) comprises herbs (or their extracts) for: (a) promoting blood flow and reducing coagulated blood levels; (b) calming; (c) sedation; and (d) flow of 'Qi'. Herb (a) is Salvia multiorhiza, Lablab pruprueus, Dendranthema x grandiflorum, Cyperus rotundus, Prunus persica, Prunus davidiana, Paeonia sufruticosa, Senna tora, Tribulus terrestris, Paeonia lactiflora, Crocus sativus, Andrographus paniculata, Ligusticum chuanxiong, Gardenia jasminoidesor Cryptotaenia japonica. Herb (b) is Lilium brownii, Ziziphus jujuba, Polygala tenuifolia, Atractylodes macrocephala, Triticum aestivum, Acorus calamus, Anemarrhena asphodeloides, Phyllostachys nigraor Ocimum basilicum. Herb (c) is Rehmannia glutinosa, Gentiara triflora, Gentiann scabraor Schisandra chinensis. Herb (d) is Citrus cinensis, Citrus aurantium, Citrus reticulata, Perillas frutescens, Centella asiatica, Lingusticum sinsense, Angelica sinensis, Curcuma longa, Glycyrrhizia uralensis, Lindera strychnifolia, Gastrodia elata, Saussurea costus, Sparganium stoliniferum, Foeniculum vulgare, Angelica pubescens, Arisaemia amurense, Acorus gramineus, Anemone altaica, Gentiana macrophyllaor Gentiana dahuria. ACTIVITY : Antidepressant; Tranquilizer. In a force swimming test for antidepressant activity in mice, the immobility time for mice treated orally with 6000 mg/kg of a 1:1:1:1 mixture of dried aqueous extracts of Salvia multiorhiza, Lilium brownii, Rehmannia glutinosaand Citrus cinensiswas 114 seconds, compared with 104 seconds for mice treated orally with 10 mg/kg of imipramine and 180 seconds for vehicle-only controls. MECHANISM OF ACTION : None given in the source material.

Description

Territory of invention

The The present invention relates to a new herbal composition for avoidance and / or treatment of conditions in connection with depression.

description of the prior art

The typical depression is characterized by feelings of intense sadness and despair, mental weakening and loss of concentration, pessimistic worry, heightened excitability and self-disapproval. There are also physical changes especially in severe or "melancholic" depression include insomnia or hyposomy, loss of appetite and Weight loss (or sometimes overeating), decreased energy and libido and disturbance of normal daily rhythms regarding activity, body temperature and many endocrine functions. There are many causes of depression and the causes can genetic, familial, biochemical, physical, social and psychological factors include. The typical depression occurs in all groups of People on and attacks both sexes with an increased incidence in females, mainly morbid Girl, and affects 5 - 10% the population.

Depressive disorders are often managed by long-term medication with antidepressants. The following antidepressants are widely used in the world: selective sertonine reuptake inhibitors (SSRIs), tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors (MAOIs). A number of SSRIs such as Setralin, Fluoxetine, Paroxetine and Fluvoxamine, TCAs such as ELAVIL ^™ , MAOIs such as Nardil, Parnat and L-Deprenyl have been developed to treat depression. However, these medications are potent and often cause problematic side effects such as lethargy, clouded mind, lack of concentration, and sexual dysfunction. For example, the side effects of using TCAs are sedation and weight gain, and the MAOIs cause diet and drug interactions. Especially sexual disorders have long been found to be both a symptom of depressive illness and as a side effect of many antidepressants. JM Ferguson has shown that most antidepressants interfere with human sexual function (Ferguson JM J Clin Psychiatry 2001; 62 Suppl 3: 22-34). In addition, some new antidepressants with reduced side effects have also been developed, such as mirtazapine, bupropion and nefazodone. However, these long-term antidepressants cause a dry mouth and oral infection.

An herb, the St. John's wort, has been found to ameliorate depression and have a reduced side effect (Ghosal and Shibnath, US 6,224,906 ). For this reason, researchers are gradually measuring the development of herbal medicines weight. St. John's wort, however, is not potent in the treatment of depression, it can only be used for mild to moderate depression. It is continually desirable to provide herbal medicines that have improved antidepressant properties.

SUMMARY THE INVENTION

The present invention relates to a herbal composition comprising a herb for the promotion of circulation and reduction of clotted blood or an extract thereof, a herb for rest or an extract thereof, a herb for sedation or an extract thereof, and a herb for the Flow of qi or an extract thereof; wherein the herb is selected from the group consisting of Salvia multiorhiza, Lablab pruprueus, Dendranthema x grandiflorum, Cyperus rotundus, Prunus persica, Prunus davidiana, Paeonia suffruticosa, Senna tora, Tribulus terrestris, Paeonia lactiflora, to promote blood circulation and reduce coagulated blood. Crocus sativus, Andrographis paniculata, Ligusticum chuanxiong, Gardenia jasminoides, and Cryptotaenia japonica, the herb selected for rest from the group consisting of Lilium brownii, Ziziphus jujuba, Polygala tenuifolia Atractylodes macrocephala, Triticum aestivum, Acorus calamus, Anemarrhena asphodeloides and Phyllostachys nigra , and Ocimum basilicum, and the herb selected for sedation is selected from the group consisting of Rehmannia glutinosa, Gentiana triflora, Gentian scabra and Schisandra chinensis, and the herb selected for the flow of Qi is selected from the group consisting of Citrus sinensis, Citrus aurantium, Citrus reticulata, Perillas frutesc ensence, Centella asiatica, Ligusticum sinense, Angelica sinensis, Curcuma longa, Glycyrrhiza uralensis, Lindera strychnifolia, Gastrodia elata, Saussurea costus, Sparganium stoloniferum, Foeniculum vulgare, Angelica pubescens, Arisaema amurense, Acorus gramineus, Anemone altaica, Gentiana macrophylla, Gentiana dahurica.

The The invention also relates to a method for treatment and / or avoidance the conditions associated with depression, including administering an effective amount of the composition of the invention to a Person who needs this.

The The present invention relates to a novel herbal composition which is antidepressant Effects. The herbal composition The invention has improved prevention effectiveness and / or treatment of the conditions associated with depression and does not cause any side effects.

Herbal composition

The The present invention provides a herbal composition comprising a herb to promote the circulation and reduction of clotted blood or one Extract from it, a herb for the rest or an extract thereof, a herb for sedation or an extract of it, and a herb for the flow of Qi or one Extract thereof; Taking the herb to promote blood circulation and Reduction of clotted blood is selected from the group consisting Salvia multiorhiza, Lablab pruprueus, Dendranthema x grandiflorum, Cyperus rotundus, Prunus persica, Prunus davidiana, Paeonia suffruticosa, Senna tora, Tribulus terrestris, Paeonia lactiflora, Crocus sativus, Andrographis paniculata, Ligusticum chuanxiong, Gardenia jasminoides, and Cryptotaenia japonica, the herb selected for rest from the group consisting of Lilium brownii, Ziziphus jujuba, Polygala tenuifolia Atractylodes macrocephala, Triticum aestivum, Acorus calamus, Anemarrhena asphodeloides and Phyllostachys nigra, and Ocimum basilicum, and the herb is selected for sedation from the group consisting of Rehmannia glutinosa, Gentiana triflora, Gentiann scabra and Schisandra chinensis, and the herb is selected for the flow of qi from the group consisting of Citrus sinensis Citrus aurantium, Citrus Reticulata, Perillas frutescens, Centella asiatica, Ligusticum sinense, Angelica sinensis, Curcuma longa, Glycyrrhiza uralensis, Lindera strychnifolia, Gastrodia elata, Saussurea costus, Sparganium stoloniferum, Foeniculum vulgaris, Angelica pubescens, Arisaema amurense, Acorus gramineus, Anemone altaica, Gentiana macrophylla, Gentiana dahurica. Preferably, the herb is for promotion the blood circulation and reduction of clotted blood selected the group consisting of Salvia multiorhiza and Andrographis paniculata, the herb for the rest is selected from the group consisting of Lilium brownie and Polygala tenuifolia, the herb for sedation is selected from the group from Rehmannia glutinosa and Schisandra chinensis, and the herb for the River of Qi is selected from the group consisting of Citrus sinensis, Citrus aurantium, Citrus reticulata and Perillas frutescens. More preferably the herb for promotion the circulation and reduction of clotted blood Salvia multiorhiza, the herb for the rest is Lilium brownie, the herb for sedation is Rehmannia glutinosa, and the herb for The flow of Qi is Citrus sinensis.

Chinese medicine represents a complete system of healing that encompasses the whole range of human experience. Chinese medicine is a combination of poetry and science, based on a dynamic understanding of energy and movement. According to traditional Chinese medical theory, the body's fundamental substances are qi (pronounced "chi"), blood, jing, shen, and bodily fluids.The proper formation, maintenance, and circulation of these substances is essential to health. Concept based on the ancient Chinese initial understanding of natural phenomena, that is, Qi is the most elemental substance in the world, everything in the universe results from the movements and changes of Qi. Qi in the human body is different in classification and formation In general, qi has no more than two sources, one is the immanent essential substance that one inherits from one's parents at birth, the other is the essence of nutrition and the fresh air that comes from the air, water, and food in the natural world The meaning of qi has two aspects: one relates on the essential substances that the human body contains to sustain its life activities, such as the qi of water and food (the essence of food), the qi of breathing (respiratory nutrients), and so on. The other refers to the physiological function of the intestines and intestines, ducts and collaterals, such as the heart qi, the lung, the spleen and the stomach, and so on. Qi deficiency is fatigue and under-function: a part or parts of the body can not do their job. The usual signs of Qi-deficiency include a low-pitched and weak voice that easily gets out of breath, sweating when there is no apparent reason, fatigue, fluid bowel movements, and loss of appetite. However, there are many more specific signs of Qi deficiency. For example, if the lung qi is not working properly, we are breathless, pale, have a weak voice, and often catch cold. If the gastric Qi has a hypofunction, lose If we lose our appetite, can not eat food properly, feel too fast fed up, get thin or loose bowel movements, and feel weak, especially in the morning. Both of these Qi deficiency functions can lead to general fatigue. When the heart has qi deficiency, we also get palpitations: every zang-fu has its own image when it has qi deficiency symptoms.

As used herein, "blood" is actually one other form of qi, just thicker than the "qi stuff" that gives us vitality and life is the mother energy in the body: It forms muscles, bones, tissues and all the rest. It provides a resting place for the qi. Indeed the Chinese say that while Qi guides the blood, blood is the mother of Qi. So use them the term blood in a different way than western medicine. From the Chinese point of view, what we call blood is simple just a red liquid, unless it has qi when it becomes blood. How is the red Substance to blood? The beginning of the process depends on a good stomach qi, to feel hungry, to eat, to swallow, and the right food and fluids digest and transfer them to the first stage of the red fabric. This ascend to the lungs that move him to the heart, taking him Energy is given. But it only becomes blood in the heart. Consequently In Traditional Chinese Medicine (TCM), one says that the heart the blood reigns ". The main function of the blood is to nourish, moisten and moisturize the body a place for to provide the spirit where to dwell and prosper. Words that the activities of the blood include stability, smoothness, good texture, Ingenuity and good character. There are four types of blood disharmonies. When we have blood-deficiency functions, we get paleness, dryness, Fragility of Joints and nails, inner restlessness, irritability, restlessness, a weak memory and weak concentration, hair loss, depression, insomnia, weak eyesight or tired Eyes, impotence or weak periods and infertility, whole not to mention dizziness and numbness (Not necessarily alltogether. However, some of these problems can be shared by others Causes in TCM). And these are just the appetizers. Blood Deficiency occur when the spleen energy is insufficient, which means that our digestion fails to digest the right food and turn them into blood.

The Chinese medicine usually incorporates various herbs. A usual used preparation or template for the development of herbal recipes based on the monarchical form of government. At the top stands the king or emperor. This is followed by the ministers or deputies. At the end come the staff or aides. Every herb can do any of these Fill roles. Which role depends It depends on which recipe the herb is used in. The roles work together in this way: (i) Royal weed - mainly responsible for referral with the symptom to be treated; (ii) Saxifrage - helps the kingwort at the reinforcement the effect of the royal kraut and in the treatment of the same syndrome; (iii) helper - plays one of the three roles: helps the king's weed, controls the unwanted actions of the royal kraut or reduces the toxic effects; and (iv) Servant Herb: plays two basic roles: directing the formulation towards the affected one Region, and matching the herbs in the formulation.

The The above-mentioned theory of Chinese medicine can be found on the Websites www.tcm.healthinfo.org, www.chinesemedicinesampler.com, www.acuhealing.com, http://website.linione.net/~balloonz/enhc.htm etc. The herbal composition The invention is based on the above theory of developed Chinese medicine.

Additionally finds the information concerning the herbs described herein on the website: www.ibiblio.org/pfaf.

Herbs for reinforcement circulation and to reduce clotted blood

According to the invention, the herb used in the composition for enhancing blood circulation and reducing coagulated blood plays the role of the royal herb, which is mainly responsible for the antidepressant action. According to the invention, this is selected from the group consisting of Salvia multiorhiza or the extract thereof, Lablab pruprueus or the extract thereof, Dendranthema x granduiflorum or the extract thereof, Cyperus rotundus or the extract thereof for enhancing the blood circulation and for reducing coagulated blood. Prunus persica or the extract thereof, Prunus davidiana or the extract thereof, Paeonia suffruticosa or the extract thereof, Senna tora or the extract thereof, Tribulus terrestris or the extract thereof, Paeonia lactiflora or the extract thereof, Crocus sativus or the extract thereof, Andrographis paniculata or the extract thereof, Ligusticum chuanxiong or the extract thereof, Gardenia jasminoides or the extract thereof, and Cryptotaenia japo nica or the extract thereof. According to the invention, the above-mentioned herbs have the efficacy of enhancing blood circulation and reducing coagulated blood. The above-mentioned herbs to increase circulation and reduce clotted blood are able to increase blood flow and improve circulation problems. The Latin name, synonyms, possible synonyms, and common names of the above herbs to enhance blood flow and reduce coagulated blood are shown in Table 1 below:

Table 1

Salvia multiorhiza, which has long been used in Chinese medicine will tend to be up to 0.6m tall become. The latest research showed that it is cardiovascular problems can be used (Chevallier A., The Encyclopedia of Medicinal Plants Dorling Kindersley, London, 1996, ISBN 9-780751-303148.). According to the Chinese Medical theory, Salvia multiorhiza is used in the treatment from bad qi of the heart and abdomen, perpetual Gargle the entrails such as water flow, cold and Heat, and accumulations and accumulations. (Chevallier, A. The Encyclopedia of Medicinal Plants Dorling Kindersley. London 1996 ISBN 9-780751-303148).

lablab purpureus tends to grow up to 2m tall. Lablab purpureus has anticholesterolemic effects, as Antidote, against alcohol dependence, windy and hypoglycemic and can historically be used in the treatment of cholera, vomiting, diarrhea, leucorrhoea, gonorrhea, alcohol intoxication and puffer poisoning (A Barefoot Doctors Manual. Running Press 1975 ISBN 012-126540-x).

Dendranthema x grandiflorum tends to grow to 1.5m tall. Dendranthema x grandiflorum shows antibacterial, antifungal, anti-inflammatory, windy, cleansing, antipyretic, ophthalmic, cooling and calming effects and may be used in the treatment of hypertension, coronary heart disease and angina are used (Bown. D., Encyclopedia of Herbs and their Uses, Dorling Kindersley, London. 1995, ISBN 0-7513-020-31.).

Cyperus rotundus tends to grow to 0.6m in size. historically It can be seen in the treatment of digestive problems and menstrual problems (Bown, D., Encyclopaedia of Herbs and their Uses, Dorling Kindersley, London. 1995, ISBN 0-7513-020-31.).

Prunus persica tends to grow to 6m tall become. Historically, it can be used in the treatment of gastritis, Whooping cough, cough and bronchitis are used (Bown. D., Encyclopedia of Herbs and their Uses, Dorling Kindersley, London. 1995, ISBN 0-7513-020-31.).

Prunus davidiana tends to grow up to 9m tall. historically seen in the treatment of missed menstrual periods, dysmenorrhea, traumatic pain due to congestion, constipation old and debile patients, cough and asthma are used (Yeung Him-Che, Handbook of Chinese Herbs and Formulas, Institute of Chinese Medicine, Los Sangeles, 1985).

Paeonia suffroticosa tends to grow to 2m tall. historically seen in the treatment of fevers, boils, menstrual disorders, Nosebleeds, ulcers, Irritability and gastrointestinal infections are used (Bown, D., Encyclopedia of Herbs and their Uses, Dorling Kindersley, London. 1995, ISBN 0-7513-020-31.).

Senna Tora prefers light, medium and heavy soils. Historically It can be used to treat skin diseases.

Tribulus terrestris is an exceptional cure for urogenital diseases that promotes urinary flow, calms the mucosa and aids in the clearance of stones (Fraley et al., 1986, The Yoga of Herbs: An Ayurvedic Guide to Herbal Medicine, Santa Fe: Lotus Press .). In traditional Chinese medicine, Tribulus terrestris is used to treat headache, dizziness, and dizzy spells due to the rising liver-yang, and eliminates wind heat for red-eye and excessive tears, promotes lactation and is used in the treatment of hives.

Paeonia lactiflora tends to grow to 0.75m. historically It can be seen in the treatment of hemorrhoids and varicose veins (Page M., The Gardener's Guide to Growing Peonies, Newton Abbot, 1997, ISBN 07153-0531 X.).

Crocus sativus tends to grow to 0.1m in size. historically It can be seen in the treatment of chronic bleeding in the Used uterus and menstrual pain and the initiation of menstruation become.

Andrographis paniculata is widely used in traditional Chinese medicine as anti-inflammatory and fever remedy for the treatment of cold, fever, Laryngitis and diarrhea used.

Ligusticum sinense tends to grow to 1m tall become. Historically, it can be used in the treatment of menstrual problems, postpartum bleeding, coronary heart disease, poor circulation and headaches are used (Bown, D., Encyclopedia of Herbs and their Uses, Dorling Kindersley, London. 1995, ISBN 0-7513-020-31.).

Herb for the rest

According to the invention plays the herb used in the composition of the invention for the rest the role of the herb that enhances the effect of the herb the blood circulation and the reduction of clotted blood. According to the invention is the herb for the rest selected from the group consisting of Lilium brownie or the extract thereof, Ziziphus jujube or the extract thereof, Polygala tenuifolia or the extract thereof, Altractylodes macrocephala or the extract from it, Triticum aestivum or the extract thereof, Acorus calamus or the extract thereof, Anemarrhena asphodeloides or the extract from it and Phyllostachys nigra or the extract from it. The above Herbs for the Rest have a calming effect and are capable of feeling and feeling anxious To reduce depression. The Latin name, synonyms, possible synonyms and the common ones Names of the above herbs for the Rest are shown in Table 2 below.

Table 2

Lilium Brownii tends to grow to 1.2m. historically It can be seen in the treatment of cough and hematemesis due to a state of lack, anxiety, dark premonitions, edema and difficulty urinating be used.

Watkins jujube tends to grow to 10m tall become. Historically, it can be used to help for the Gain weight, improve muscle strength and increase the Endurance. In Chinese medicine, it is used as a tonic to strengthen the body Liver function prescribed (Chevallier, A. The Encyclopedia of Medicinal Plants Dorling Kindersley. London 1996 ISBN 9-780751-303148.).

Polygala tenuifolia tends to grow to 0.2m in size. historically It can be used in the treatment of cough plenty of mucus, bronchitis, insomnia, palpitations, weak Memory, Anxiety, Depression and more nervous Suspense (Bown, D., Encyclopaedia of Herbs and their Uses, Dorling Kindersley, London. 1995, ISBN 0-7513-020-31.).

Atractylodes macrocephala, which is widely used in traditional Chinese medicine used tends to grow up to 0.5m. historically Seen it can be used in the treatment of bad Appetite, dyspepsia, abdominal distension, chronic diarrhea, edema and spontaneous sweating (Yeung Him-Che, Handbook of Chinese Herbs and Formulas, Institute of Chinese Medicine, Los Angeles, 1985).

Triticum aestivum tends to grow to 1.5m tall. historically Seen it can be used for the treatment of nocturnal Sweating and spontaneous sweating (Yeung Him-Che, Handbook of Chinese Herbs and Formulas, Institute of Chinese Medicine, Los Angeles, 1985).

Acorus calamus tends to grow to 1m tall become. Historically, it can be used in the treatment from indigestion, Bronchitis, Sinusitis (Bown D., Encyclopedia of Herbs and their Uses, Dorling Kindersley, London. 1995, ISBN 0-7513-020-31.).

anemarrhena asphodeloides tends to grow to 0.5m in size. historically It can be used in the treatment of ulcers (Bown. D., Encyclopedia of Herbs and their Uses, Dorling Kindersley, London. 1995, ISBN 0-7513-020-31.).

Platycodon grandiflorus tends to grow to 0.5m tall. historically It can be used in the treatment of cough plenty of mucus, colds, Bronchitis, pleurisy, Lung abscesses and throat infections (Bown. D., Encyclopedia of Herbs and their Uses, Dorling Kindersley, London. 1995, ISBN 0-7513-020-31.).

Herbs for sedation

According to the invention the herb plays for sedation, that in the composition of the invention is used, the role of the Hilfskrauts, which affects the action of the herb to improve blood circulation and reduce clotted Promotes blood. According to the invention the herb is selected for sedation from the group from Rehmannia glutinosa or the extract thereof, Gentiana triflora or the extract thereof, Gentiana scabra or the extract thereof and Schisandra chinensis or the extract thereof. The above herbs for Sedation show hemostatic and soothing effects and can Reduce dizziness. The Latin name, synonyms, possible synonyms and the common ones Names of the above herbs for sedatives are shown in Table 3 below.

Table 3

Rehmannia Glutinosa usually becomes in Chinese herbalism used where it is one of the most common strengthening Herbs is. Rehmannia glutirosa tends to grow to 0.3m. Historically, it is used to replenish energy and improves states associated with diabetes, constipation, urinary tract problems, Anemia, Dizziness, and regulates menstruation. Rehmannia glutinosa shows Effects in the protection of the liver, whereby it is the depletion of stored Prevents glycogen and prevents fungi such as candida. About that In addition, it can reduce the level of glucose, lower blood pressure, strengthen the bones and the tissue and increase fertility. In combination with licorice was Rehmannia glutinosa in traditional Chinese medicine Treatment of hepatitis used. In the theory of Chinese Medicine can derive Rehmannia glutinosa heat from the body and nocturnal Sweat and relieve fever and can be used in this way be used to treat faulty blood pictures with the symptoms such as pale face, dizziness, palpitations and insomnia. The root of Rehmannia glutinosa, called the Kiou and prepared by Method was classified, was in ancient times, the Han Dynasty, used, each production being given a different name, i.e., Chinese thimble, Syoujiou, Kanjiou and Zyukujiou. It grows throughout the year between 0.3m to 0.25m and can be in partial shade (bright forest) or no shade (Reid.B.E. A translation of an ancient Chinese book on edible wild foods. Fascinating. Famine Foods of the Chiu-Hunag Pents'ao, Taipei, Southern Materials Center 1977).

Gentiana triflora tends to grow to 0.5m in size. The Gentiara triflora contains some known compounds with a good effect on the digestive system. It can be used in the treatment of jaundice, leucorrhea, Rash, conjunctivitis, sore throat, acute infections of the Urinary system, hypertension with dizziness and tinnitus (Yeung, Him-Che, Handbook of Chinese Herbs and Formulas, Institute of Chinese Medicine, Los Angeles, 1985).

Gentiana scabra tends to grow to 0.3m in size. Gentiana scabra is used as a bitter tonic in Chinese herbalism, where it promotes digestive juices and treats a range of diseases associated with the liver. It can be used in the treatment of jaundice, leucorrhoea, rash, conjunctivitis, sore throat, acute urinary tract infections, hypertension with dizziness and tinnitus (Yeung, Him-Che, Handbook of Chinese Herbs and Formulas, Institute of Chinese Medicine, Los Angeles, 1985).

Schisandra chinensis tends to grow to 9m tall. Schisandra chinensis, that is an excellent strengthening and tonic is, becomes frequent in Chinese herbalism used where it helps stressful times and the lust for life elevated (Chevallier A., The Encyclopaedia of Medicinal Plants Dorling Kindersley, London 1996, ISBM 9-780751-303148).

Herb for the river of the Qi

According to the invention play the herb for the flow of Qi used in the composition of the invention becomes the role of the servant's cabbage, which is the composition of the invention Towards the affected area and the herbs in harmonized in the composition. According to the invention, the herb is for the River of Qi selected from the group consisting of Citrus sinensis or the extract thereof, Citrus aurantium or the extract thereof, Citrus reticulate or the extract thereof, Perilla frutescens or the extract thereof, Centella asiatica or the extract thereof, Ligusticum sinense or the extract thereof, Angelica sinensis or the extract thereof, Curcume longa or the extract thereof, Glyceyrrizha uralensis or the extract from it, Lindera strychnifolia or the extract thereof, Gastrodia elata or the extract thereof, Saussurea costus or the extract from it, Sparganium stoloniferum or the extract thereof, Foeniculum vulgare or the extract thereof, Angelica pubescens or the extract from it, Arisaema amurense or the extract thereof, Acorus gramineus or the extract thereof, Anemone altaica or the extract thereof, Gentiana macrophylla or the extract thereof, and Ocimum basilicum or the extract thereof. The Latin name, synonyms, possible synonyms and the common ones Names of the above herbs for the Flow of Qi are shown in Table 4 below.

Table 4

Citrus sinensis tends to grow to 9m tall become. Historically, it can be used as one Source of antioxidants and chemical peeling agents in special cosmetics (Bown, D., Encyclopedia of Herbs and their Uses, Dorling Kindersley, London, 1995, ISBN 0-7513-020-31.).

Citrus aurantium tends to grow to 9m tall. historically seen in the treatment of dyspepsia, constipation, abdominal distension, dull feeling in the chest, incidence of the uterus, of the rectum and stomach (Yeung Him-Che, Handbook of Chinese Herbs and Formulas, Institute of Chinese Medicine, Lot Angeles, 1985.).

Citrus reticulata tends to grow to 4,5m tall. historically It can be seen in the treatment of dyspepsia, gastrointestinal bloating, Cough and excessive mucus (Yeung Him-Che, Handbook of Chinese Herbs and Formulas, Institute of Chinese Medicine, Los Angeles, 1985.).

Perilla frutescens tends to grow to 0.6m in size. historically It can be seen in the treatment of asthma, colds and colds, Nausea, abdominal pain, food poisoning and allergic Reactions are used (Bown, D., Encyclopedia of Herbs and their Uses, Dorling Kindersley, London, 1995, ISBN 0-7513-020-31.).

Centella Asiatica tends to grow to 0.2m. historically seen in the treatment of wounds, chronic skin conditions, venereal diseases, Malaria, varicose veins, ulcers, nervous disorders and senility (Bown, D., Encyclopaedia of Herbs and their Uses, Dorling Kindersley, London, 1995, ISBN 0-7513-020-31.).

Ligusticum sinense may be used in the treatment of cerebral ischemia People useful (Leung et al., Neurochem. Res. 1991 Jun: 16 (6): 687-92).

Curcuma Longa is a very important herb in the Indian Ayurvedic Medicine. Medically it was used as a digestive aid and Treatment of fever, infections, dysentery, arthritis and jaundice and other liver problems. Traditional Chinese doctors used Turmeric to treat liver and gall bladder problems, bleeding to stop, and to treat chest congestion and menstrual discomfort. Curcuma longa also focuses on Commiphora (used as hypolipidemic agent), Picrorhiza (hepatoprotective), Bacopy (used as a tonic for the Brain), turmeric (anti-inflammatory) and Asclepias (cardiotonic) (Jain SK, Ciba Found Symp 1994; 185: 153-64).

Angelica sinensis, a well-known Chinese herb that has been around for thousands used by years in the treatment of female ailments was, tends to grow up to 1m become. Historically, it can be used in the treatment a big one Selection of women's diseases in which there is the menstrual cycle regulates and relieves period pain (Bown. D., Encyclopedia of Herbs and their Uses, Dorling Kindersley, London, 1995, ISBN 0-7513-020-31.).

Glycyrrhiza Ancient sence tends to grow to 0.6m. historically seen in the treatment of Addinson's disease, Asthma, cough, gastric ulcers, Acne, boils and throat infections (Bown, D., Encyclopaedia of Herbs and their Uses, Dorling Kindersley, London, 1995, ISBN 0-7513-020-31.).

Lindera strychnifolia tends to grow to 9m tall. historically It can be seen in the treatment of menstrual pain, bedwetting, frequent bladder emptying and abdominal distension to be used with pelvic pain (Yeung Him-Che, Handbook of Chinese Herbs and Formulas, Institute of Chinese Medicine, Lot Angeles, 1985.).

Gastrodia elata tends to grow to 1 meter tall. Historically, it can be used in the treatment of convulsive diseases, rheumatoid arthritis, fear of heights, and insensitivity associated with liver disarmament (Bown, D., Encyclopedia of Herbs and their Uses, Dorling Kindersley, London, 1995, ISBN 0-7513-020-31.).

Xuelian costus tends to grow up to 3m tall become. Historically, it can be used to treat abdominal distension and pain, chest pain due to liver problems and jaundice, Gallbladder pain, constipation associated with energy stagnation and asthma (Bown, D., Encyclopedia of Herbs and their Uses, Dorling Kindersley, London, 1995, ISBN 0-7513-020-31.).

Sparganium Stoloniferum may be absent in the treatment of abdominal pain Menstruation, dysmenorrhea and chest pain are used (Yeung Him-Che, Handbook of Chinese Herbs and Formulas, Institute of Chinese Medicine, Los Angeles, 1985.).

foeniculum vulgare, that usually used as a home remedy tends to grow up to 1.5m. Foeniculum vulgare can help treat a variety of ailments be used.

Angelica pubescens tends to grow to 1.8m tall. historically seen in the treatment of rheumatoid arthritis, Rheumatism, headache, toothache and abscesses are used.

Arisaema Amurense, the thousands of years in Chinese herbal medicine used tends to grow up to 0.5m. historically seen in the treatment of cough with excessive mucus, Tumors, cervical cancer, Epilepsy, tetanus and in case of discomfort, muscular spasms include, be used (Yeung Him-Che, Handbook of Chinese Herbs and Formulas, Institute of Chinese Medicine, Los Angeles, , 1985; (Bown, D., Encyclopedia of Herbs and their Uses, Dorling Kindersley, London, 1995, ISBN 0-7513-020-31.).

Acorus gramineus tends to grow to 0.3m. historically It can be seen in the treatment of digestive problems, depression and epilepsy are used (Yeung Him-Che, Handbook of Chinese Herbs and Formulas, Institute of Chinese Medicine, Los Angeles, 1985; Bown. D., Encyclopedia of Herbs and their Uses, Dorling Kindersley, London, 1995, ISBN 0-7513-020-31.).

anemone altaica tends to grow up to 0.2m in size. historically It can be seen in the treatment of loss of appetite and gastrointestinal bloating, Used mental illness, melancholy, epilepsy and dysregulation (Yeung Him-Che, Handbook of Chinese Herbs and Formulas, Institute of Chinese Medicine, Los Angeles, 1985.).

Gentiana macrophylla used in Chinese herbalism for over 2000 years was, tends to up to 0.6m in size become. Historically, it can be used in the treatment of digestive disorders, Arthritis, allergic inflammation, low fever in chronic diseases, jaundice and hepatitis (Yeung Him-Che, Handbook of Chinese Herbs and Formulas, Institute of Chinese Medicine, Los Angeles, 1985; Bown. D., Encyclopedia of Herbs and their Uses, Dorling Kindersley, London, 1995, ISBN 0-7513-020-31.).

Gentiana dahurica tends to grow to 0.3m. historically seen in the treatment of arthritis, allergic inflammation, low fever in chronic diseases, jaundice and hepatitis (Yeung Him-Che, Handbook of Chinese Herbs and Formulas, Institute of Chinese Medicine, Los Angeles, 1985; Bown. D., Encyclopedia of Herbs and their Uses, Dorling Kindersley, London, 1995, ISBN 0-7513-020-31.).

Ocimum basilicum tends to grow to 0.45m. historically seen in the treatment of febrile diseases, bad digestion, nausea, Abdominal cramps, Gatroenteritis, Migraine, Insomnia, depression and fatigue are used (Bown. D., Encyclopedia of Herbs and their Uses, Dorling Kindersley, London, 1995, ISBN 0-7513-020-31.).

According to the one preferred embodiment The invention comprises the herbal composition Salvia multiorhiza or Andrographis paniculata or the extract thereof, Lilium brownie or Polygala tenuifolia or the extract thereof, Rehmannia glutinosa or Schisandra chinensis or the extract thereof, and Citrus sinensis, Citrus aurantium, Citrus reticulata or Perilla frutescens or the extract thereof.

In accordance with the present invention, the herbal composition of the invention is a mixture of four herbs in a preferred ratio of the herb to increase blood flow and depletion of clotted blood: the herb for rest: the herb for sedation: the herb for the flow of Qi of about 1: 1: 1: 1 (w / w). The weight ratio can vary up to 50% per component. By "deviation of the weight ratio up to 50%" is meant that each value of each component of the ratio can be increased or decreased up to 50%, thus 1: 1, for example, between 1.5: 0.5 and 0, 5: 1.5 (or 3: 1 and 1: 3).

manufacturing the herbal composition

According to the invention can the components of the present invention in powder form or as by conventional solvent Extracted extracts are used. For the powder form are the components the herbal composition of the present invention air-dried and finely ground. For the extract form can the components of the present invention by conventional Solvents like for example, water or any other solvent containing active substances from the natural substances at a temperature of about 25 ° C until Boiling point of the solvent while a period of about 20 minutes to about Extract 2 hours can be extracted. The solvent from the extract solution can be removed to get the extract. The resulting Extract can optionally be filtered, concentrated and dried be treated. The exact ratio of in the composition Extracts used in this invention depend on the concentration of active ingredients naturally found in each component become. Under the guidance provided herein and a basic knowledge of drug manufacturing and pharmacology may be the expert the ratios simply adapt the individual components of the composition, so as to obtain a composition that discussed herein has therapeutic effects.

According to one preferred embodiment we invent the herbal composition prepared by extraction of the components by boiling, filtering of the resulting extract, concentrating the filtered solution and then Mixing the solution, to obtain the extract composition. Preferably, the Extraction performed for 1 hour.

According to one another preferred embodiment According to the invention, the powder composition is prepared by drying the components and grinding of the dried components, and then Mix the resulting components to the powder composition to obtain.

Dosage form of herbal composition the invention

According to the invention can the herbal composition of this invention are administered orally. The orally administered embodiments the herbal composition of this invention in every conventional Form, such as powder, capsules (hard or soft), tablets, elixirs, powders, granules, suspensions in Water or non-aqueous Media, sachets, as additives to food and drinks, or can even present as tea. For the preparation of solid, orally administered compositions such as capsules or tablets, the powder produced or extract may be mixed with a pharmaceutical carrier, including conventional ones Tabletting agents such as cornflour, lactose, sucrose, sorbitol, Talc, stearic acid, Magnesium stearate, dicalcium phosphate or gums and other pharmaceuticals diluents (e.g., water) to form a solid composition. Liquid preparations for oral administration the form of, for example, extracts, solutions, syrups or suspensions accept, or you can be presented as a dry product to restore Water or other suitable vehicle before use. Such liquid preparations can by conventional Agents with pharmaceutically acceptable additives, such as suspending agents, Emulsifiers, non-aqueous Vehicles, preservatives and artificial or natural Dyes and / or sweeteners getting produced.

According to the invention can the herbal composition of this invention in unit dosages. A Unit dosage may be a therapeutically effective amount of each herbal extract for one single daily Include administration, or it may be in smaller quantities of each ingredient be formulated to provide multiple doses in a day. One unit dosage depends of many factors, including age, size and condition of the individual to be treated, and of how often the unit taken in a day. In any case, the total daily dose to be the ones for an individual is physiologically acceptable, and daily over one longer Period of time can be administered. According to the invention, normally not more than 21 g / day of the active herbal composition, wherein a portion of the total dose preferably at two or more different Times during of the day is taken.

The The present invention is also directed to methods of treatment of depression, comprising administering an effective one Amount of herbal composition of this invention to an individual in need of a depression aid. Of the Term "effective Quantity "in relation on the herbal composition means the amount that is sufficient to connect the symptoms to relieve depression. The effective amount will depend on the severity of the symptoms and the responsiveness of the Patient on the herbal composition. Professionals can easily the optimal dosages, dosing methods and repetition rates determine.

Pharmacological activity

According to the invention can the herbal composition used in the relief of depressive states and anxiety become. An advantage of the treatment of certain cases of Depression with the herbal composition The invention is that they, as with many prescription Antidepressants, rarely from side effects such as sexual Malfunction is accompanied.

The pharmacological activity the herbal composition of the invention may be achieved by the following Forced Swimming Test (FST) be rated.

J enthält. Die Zeitdauern des Strampelns, der aktiven Bewegung und der Unbeweglichkeit im Test werden durch eine automatische Vorrichtung aufgezeichnet. 20–24 Stunden vor dem Test wurde ein 15-minütiger Vortest durchgeführt. Die Dauer der Unbeweglichkeit wird als Verzweiflungsparameter der Nagetiere verwendet. Die Nagetiere, die bei dem zweiten FST weniger Bewegung an den Tag legen als die des mit dem Vehikel behandelten oder unbehandelten Tiers, zeigen, dass das Arzneimittel antidepressive Wirkung besitzt. Der FST kann bei der Bewertung einer Vielfalt von potentiellen Antidepressiva verwendet werden, einschließlich aller getesteten TCAs (d.h., Imipramin, Amitryptylin, Nortryptilin), MAOIs (d.h., Nialamid, Ipronniazid), atypische Antidepressiva (d.h., Iprindol, Mianserin, Nomifensin)und ECT (Porsolt et al. Eur J Pharmacol 1978, 47:379–391; Borsini und Meli 1988, Psychopharmacology (Berl), 94:147–160.). Die angstlösenden Mittel und Phenothiazine können jedoch nicht durch den FST bewertet werden.Porsolt et al. developed a Forced Swimming Test (FST), in which a rodent (a rat or mouse) is placed in a water tank and the time during which the animal maintains immobility is determined. The rodents are individually placed for 6 minutes in a transparent acrylic cuboid, the 15 cm (for the mice) or 30 cm (for the rats) water at 24 + 1

Contains J. The durations of kicking, active movement and immobility in the test are recorded by an automatic device. 20-24 hours before the test, a 15 minute pre-test was performed. The duration of immobility is used as a desperate parameter of rodents. The rodents that exhibit less exercise in the second FST than the vehicle-treated or untreated animal show that the drug has antidepressant activity. The FST can be used in the evaluation of a variety of potential antidepressants, including all TCAs tested (ie, imipramine, amitryptyline, nortryptiline), MAOIs (ie, nialamide, ipronciazide), atypical antidepressants (ie, iprindol, mianserin, nomifensine), and ECT (Porsolt et al., Eur J Pharmacol 1978, 47: 379-391; Borsini and Meli 1988, Psychopharmacology (Berl), 94: 147-160.). The anxiolytics and phenothiazines, however, can not be evaluated by the FST.

The The following examples are offered for the sake of explanation and not restrictive.

EXAMPLES

example 1

Preparation of a powdered herbal composition

The Herbs Rehmannia glutinosa, Salvia miltiorrhiza, Lilium browni and Citrus Tangerina were cleaned with cold water, dried and then each crushed. Each shredded herb became 5 to 10-fold amount by weight of water was added and it was then each Extracted by boiling water through an extraction column for 30 to 60 minutes. The resulting extracts were filtered at room temperature. The filtered solutions were concentrated and then freeze dried, spray dried or heated with or without reduced pressure to make the products in powder form to obtain. The powdered herbs was in a relationship of 1: 1: 1: 1 mixed to the herbal composition to give the invention.

Example 2

Antidepressant efficacy the herbal composition the invention

animals

160-250 g male Wistar rats were selected by NSC (National Science Council, Taipei Taiwan) based. The animals were kept at constant ambient temperature (25 ± 1 ° C) and a 12: 12-h LD cycle (lighting system at 06:00, from 18:00), with food and water to disposal stood.

antidepressants

imipramine (10 mg / kg, I.P., 20 mg / kg, P.O.) and the herbal composition of the invention (6000 mg / kg, P.O. for the mice, 2400 mg / kg, P.O. For the rats) were each tested.

FST test

The Mice were in an isolated room with a normal light-dark cycle, normal food and water and prolonged ultrasound conditions (110 dB, 6000-7000 Hz) for 10 days. The FST test mentioned herein was performed. The Results are shown in Table 5 below:

Table 5

As Shown in Table 5 above, the male BALB mice that have the imipramine has been administered, a reduction in the duration of Immobility. The herbal composition The invention significantly reduces the duration of immobility for the male Wistar rats as the vehicle and shows almost the same effect like the imipramine.

Claims (14)

An herbal composition comprising a herb for promoting blood circulation and reducing clotted blood or an extract thereof, a herb for rest or an extract thereof, an herb for sedation or an extract thereof, and an herb for the flow of qi or an extract thereof; wherein the herb is selected from the group consisting of Salvia multiorhiza, Lablab pruprueus, Dendranthema x grandiflorum, Cyperus rotundus, Prunus persica, Prunus davidiana, Paeonia suffruticosa, Senna tora, Tribulus terrestris, Paeonia lactiflora to promote blood circulation and reduce clotted blood , Crocus sativus, Andrographis paniculata, Ligusticum chuanxiong, Gardenia jasminoides, and Cryptotaenia japonica, the herb selected for rest from the group consisting of Lilium brownii, Ziziphus jujuba, Polygala tenuifolia Atractylodes macrocephala, Triticum aestivum, Acorus calamus, Anemarrhena asphodeloides and Phyllostachys nigra, and Ocimum basilicum, and the herb selected for sedation is selected from the group consisting of Rehmannia glutinosa, Gentiara triflora, Gentian scabra and Schisandra chinensis, and the herb selected for the flow of Qi is selected from the group consisting of Citrus sinensis, Citrus aurantium , Citrus reticulata, Perillas fru tescens, Centella asiatica, Ligusticum sinense, Angelica sinensis, Curcuma longa, Gly Cyrrhiza uralensis, Lindera strychnifolia, Gastrodia elata, Saussurea costus, Sparganium stoloniferum, Foeniculum vulgare, Angelica pubescens, Arisaema amurense, Acorus gramineus, Anemone altaica, Gentiana macrophylla, Gentiana dahurica. herbal composition according to claim 1, wherein the herb promotes blood circulation and Reduction of clotted blood is selected from the group consisting from Salvia multiorhiza and Andrographis paniculata and the extract it. herbal composition according to claim 1, wherein the herb is selected for rest from the group consisting of Lilium brownie and Polygala tenuifolia and the extract from it. herbal composition according to claim 1, wherein the herb is selected for sedation from the group consisting of Rehmannia glutinosa and Schisandra chinensis and the extract thereof. herbal composition according to claim 1, wherein the herb is selected for the flow of Qi from the group consisting of Citrus sinensis, Citrus aurantium, Citrus reticulata and Perillas frutescens and the extract thereof. herbal composition according to claim 1, wherein the herb promotes blood circulation and Reduction of clotted blood or the extract thereof, the herb for the Rest or the extract thereof, the herb for sedation or the extract from it, and the herb for the flow of qi and the extract thereof in a weight ratio in a range of about 1.5: 0.5 to 0.5: 1.5: 1.5: 0.5 to 0.5: 1.5: 1.5: 0.5 to 0.5: 1.5 : 1.5: 0.5 to 0.5: 1.5. herbal composition according to claim 6, wherein the herb promotes blood circulation and Reduction of clotted blood or the extract thereof, the herb for the Rest or the extract thereof, the herb for sedation or the extract from it, and the herb for the flow of qi and the extract thereof in a weight ratio of approximately 1: 1: 1: 1. Herbal composition, comprising Rehmannia glutinosa or the extract thereof, Salvia multiorhiza or the extract thereof, Lilium brownie or the extract thereof, and Citrus sinensis or the extract thereof. herbal composition according to claim 8, wherein Rehmannia glutinosa, Salvia multiorhiza, Lilium brownie and Citrus sinensis are present in the extract form. herbal composition according to claim 8, wherein Rehmannia glutinosa or the extract thereof, Salvia multiorhiza or the extract thereof, Lilium brownie or the extract thereof, and Citrus sinensis or the extract thereof in a weight ratio of about 1.5: 0.5 to 0.5: 1.5 1.5: 0.5 to 0.5: 1.5: 1.5: 0.5 to 0.5: 1.5: 1.5: 0.5 to 0.5: 1.5. herbal composition according to claim 8, wherein Rehmannia glutinosa or the extract thereof, Salvia multiorhiza or the extract thereof, Lilium brownie or the extract thereof, and Citrus sinensis or the extract thereof in a weight ratio of about 1: 1: 1: 1. A composition according to claim 1, wherein the composition an orally administered composition is selected in a form the group consisting of capsules, tablets, elixirs, powders, granules, Suspensions, sachets, food additives, beverage supplements and Tea. A composition according to claim 1, wherein the composition an orally administered composition is selected in a form the group consisting of capsules, tablets, elixirs, powders, granules, Suspensions, sachets, food additives, beverage supplements and Tea. A composition according to claim 8, wherein the composition an orally administered composition is selected in a form the group consisting of capsules, tablets, elixirs, powders, granules, Suspensions, sachets, food additives, beverage supplements and Tea.