CN104474038A - Nano Xiao'er Qifeng San and preparation method thereof - Google Patents
Nano Xiao'er Qifeng San and preparation method thereof Download PDFInfo
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Abstract
The invention discloses nano Xiao'er Qifeng San and a preparation method thereof. The nano Xiao'er Qifeng San is prepared from 500-800 parts of scorpion, 1,000-1,500 parts of fructus gleditsiae, 1,000-1,500 parts of rhubarb, 150-200 parts of angelica sinensis, 50-100 parts of mix-fried sal ammoniac, 50-100 parts of defatted croton seed powder, 3,000-3,500 parts of cinnabar and 20-50 parts of calculus bovis factitious. According to the method, Xiao'er Qifeng San is prepared with the nano technology, the content of free mercury in cinnabar can be reduced through ball milling and grinding in water, toxicity of rhubarb cooked by yellow wine is small, the medicine efficacy is high, further, the quality is stable, and the bioavailability is high; and besides, the preparation method is simple, does not require any special equipment and is applicable to industrial production.
Description
Technical field
The present invention relates to traditional Chinese medicine preparation field, be specifically related to a kind of nano children's infantum tetanus and fall apart and preparation method thereof.
Background technology
The loose full side of infantile neonatal tetanus by Scorpio, Fructus Gleditsiae Abnormalis, Radix Et Rhizoma Rhei, Radix Angelicae Sinensis, Sal Ammoniacus (processing), Fructus Crotonis, Cinnabaris, artificial Calculus Bovis totally 8 tastes form.There is heat clearing away wind dispelling, relieving convulsionly to eliminate the phlegm.Easily frightened for dossing of causing of nascent children's's tire fire interior-heat, uneasiness of crying, fever of the body flushed complexion, cough with copious phlegm, constipation, convulsion with spasms.
Loose the adopting of infantile neonatal tetanus of the prior art obtains with the following method: flown by Cinnabaris water or be ground into impalpable powder; Scorpio, Fructus Gleditsiae Abnormalis, Radix Et Rhizoma Rhei, Radix Angelicae Sinensis and Fructus Crotonis are ground into fine powder; Then by Sal Ammoniacus, Calculus Bovis porphyrize, with above-mentioned powder facing-up, sieve, mixing, obtains infantile neonatal tetanus and falls apart.Instructions of taking is oral, a 0.075g.The shortcoming that the infantile neonatal tetanus adopting this kind of preparation method to obtain is loose is: drug effect is not high, and toxicity is comparatively large, and discharge function is too strong, gentle not as children; And the more important thing is in prolonged storage, stability is good not, and likely produce soluble mercury or free mercury, safety is bad.
Summary of the invention
The invention provides a kind of nano children's infantum tetanus to fall apart and preparation method thereof, the toxicity that the nano children's infantum tetanus that this preparation method obtains is loose obviously reduces, and curative effect is improved simultaneously.
The preparation method that nano children's infantum tetanus is loose, comprises the following steps:
(1) Scorpio, Fructus Gleditsiae Abnormalis, Radix Angelicae Sinensis and Semen Crotonis Pulveratum four Chinese medicine material nano grinder are carried out nanorize pulverizing and obtain nano powder;
(2) adopt ball milling elutriation to concoct Cinnabaris, drying and screening, obtains cinnabar powder;
The process of described ball milling elutriation is as follows: by Cinnabaris except scrap iron removing, put in ball mill pulverizing tank, add medical material weight 3 ~ 5 times of water simultaneously, under rotating speed is 250 ~ 400rpm condition, waterproof pulverization is carried out to Cinnabaris and obtain suspension in 30 ~ 60 minutes, then through the powdery solid that sucking filtration, centrifuge dehydration obtain, in hot air circulation case, further drying obtains cinnabar powder;
(3) adopt yellow wine to concoct Radix Et Rhizoma Rhei, drying and screening, obtains Radix Et Rhizoma Rhei powder;
(4) by Sal Ammoniacus and artificial Calculus Bovis's porphyrize, the nano powder obtained with step (1) ~ (3), cinnabar powder and Radix Et Rhizoma Rhei powder facing-up, sieve, mix, obtain described nano children's infantum tetanus and fall apart.
Cinnabar contained by medical material Cinnabaris and its pharmacologically active closely related, the toxicity of cinnabar to human body itself is less, if but concocting method is improper, cinnabar can be caused to decompose or contain more soluble mercury or free mercury, this can cause the toxicity of medicine excessive.The present invention have employed new concocting method to Cinnabaris, under the prerequisite that ensure that Cinnabaris physiologically active, greatly reduce the toxicity of Cinnabaris, and infantile neonatal tetanus can also be improved significantly to fall apart the stability of middle Cinnabaris, decrease the decomposition of Cinnabaris in storage process, avoid the toxic increase of medicament storage process, improve the loose stability of infantile neonatal tetanus and safety.
As preferably, the weight portion of medical material used is as follows:
Scorpio 500 ~ 800 parts of Fructus Gleditsiae Abnormalis 1000 ~ 1500 parts of Radix Et Rhizoma Rhei 1000 ~ 1500 parts
Radix Angelicae Sinensis 150 ~ 200 parts of Sal Ammoniacuss 50 ~ 100 parts of Semen Crotonis Pulveratums 50 ~ 100 parts
Cinnabaris 3000 ~ 3500 parts of artificial Calculus Boviss 20 ~ 50 parts.
As preferably, in step (1), the time that nanorize is pulverized is 0.5 ~ 6 hour, and the mean diameter of the nano powder obtained is 100 ~ 300nm.Containing scorpion venom in Scorpio, can respiratory paralysis be made, and after nano-pulverization, beyond thought toxalbumin is destroyed, reach and fall hypotoxic object.As further preferred, the time that nanorize is pulverized is 1 hour, and the mean diameter of the nano powder obtained is 200nm.
As preferably, in step (2), the consumption of water and the mass ratio of Cinnabaris are 1.5 ~ 2.5:1;
Baking temperature is 30 ~ 50 DEG C.Now, the Cinnabaris physiologically active obtained is good, and toxicity is low, and stability is better.
Main component under Radix Et Rhizoma Rhei rushes down is anthraquinone and derivant, and major part exists with conjunction type anthra-glucoside form, wherein the strongest with Sennoside A discharge function in dianthrone glycosides again.Radix Et Rhizoma Rhei is without heat treatment, and combined anthraquinone constituents is without destruction, therefore discharge function is too violent.As preferably, in step (3), Radix Et Rhizoma Rhei is adopted and is concocted with the following method: put by Radix Et Rhizoma Rhei in pressure cooker, add the steaming and decocting of 8 ~ 10 times of weight yellow wine, design temperature is 100 ~ 130 DEG C, time is 1.5 ~ 2.5h, and after steaming and decocting completes, taking-up Radix Et Rhizoma Rhei is dried at heated-air circulation oven, obtains described Radix Et Rhizoma Rhei powder.After adopting method process of the present invention, combined anthraquinone reduces to some extent, but still retains a small amount of various anthracene and to wake up analog derivative, and sennoside only remaining trace, therefore discharge function weakens, and toxicity is little, is suitable for child and uses.As further preferred, bake out temperature is 40 ~ 60 DEG C, and drying time is 3 ~ 5h.
Present invention also offers a kind of nano children's infantum tetanus to fall apart, prepared by described preparation method.This nano children's infantum tetanus is fallen apart the simple and good effect of prescription, and toxin is low simultaneously, and steady quality, there is not agglomeration.
Crude drug of the present invention specifically describes as follows:
Scorpio: there is " spasmolytic that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., antiinflammatory counteracting toxic substances, removing obstruction in the collateral to relieve pain " function; Cure mainly diseases such as " infantile convulsion, tic spasm, dermatosis, cardiovascular and cerebrovascular disease, inflammation, hepatitis B, tumors ".
Fructus Gleditsiae Abnormalis: eliminate the phlegm and have one's ideas straightened out, mass dissipating and swelling eliminating.For apoplexy locked mouth, remain unconscious, epilepsy abundant expectoration, pass key is obstructed, sore throat stagnation of phlegm, and pertinacious phlegm is breathed with cough, and coughs up phlegm not well, constipation due to dry stool; External treatment carbuncle.
Radix Et Rhizoma Rhei: purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.For excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, and heat in blood tells nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire; Upper gastrointestinal hemorrhage.Radix et Rhizoma Rhei (stir-fried with wine) is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system.For conjunctival congestion pharyngeal swelling, gingivitis.Radix Et Rhizoma Rhei rushes down exerts oneself to delay, eliminating fire and detoxication.For pathogenic fire,toxin and furuncles.
Radix Angelicae Sinensis: all cards of blood deficiency; Menoxenia; Amenorrhea; Dysmenorrhea; Lump in the abdomen knot is poly-; Metrorrhagia; Asthenia cold abdominalgia; Flaccidity syndrome and arthralgia syndrome; Numbness of the skin; Dryness of the intestine dyschezia; Heavy after bloody dysentery; Ulcer sores; Injury from falling down.
Sal Ammoniacus: be mainly used in removing food stagnancy softening the hard mass, drastically removing blood stasis and resolving static blood.Control lump in the abdomen Xuan tinea, dysphagia and regurgitation, phlegm retention, sore throat, long-pending dysentery, amenorrhea, corneal nebula, polyp, warty vegetation, furuncle, scrofula, carbuncle, malignant boil.
Semen Crotonis Pulveratum: primary treatment drastic purgation stagnates, detumescence of relieving oedema or abdominal distension through diuresis or purgation, eliminating phlegm sore-throat relieving.For cold accumulation and constipation, breast food is stagnated, lower abdomen edema, constipation and anuresis, acute throat trouble, sore throat.
Cinnabaris: clear away heart-fire relieving convulsion, removing toxic substances of calming the nerves.For palpitation and being susceptible to fright, insomnia and dreamful sleep, epilepsy is gone mad, infantile convulsion, blurring of vision, aphtha, sore throat, sore swollen toxin.
Artificial Calculus Bovis: clear away heart-fire, eliminating phlegm, has one's ideas straightened out, cool liver, endogenous wind stopping, removing toxic substances.For calentura coma, middle wind-phlegm fan, infantile convulsion is twitched, and epilepsy is gone mad, laryngopharynx swelling and pain, aphtha of the mouth and tongue, carbuncle furuncle.
This product specification is often packed 0.15 gram; Usage and dosage: oral, one time 0.075 gram.
Compared with the existing technology, beneficial effect of the present invention is:
(1) ball milling water flies to make the content of free mercury in Cinnabaris to decline, and the toxicity reducing Cinnabaris, to bottom line, can be increased work efficiency again, reduce labor intensity.
(2) Radix Et Rhizoma Rhei is after wine processing is dried, and partial derivatives content declines, and therefore discharge function weakens, and toxicity is little, is suitable for child and uses.
(3) by nano-pulverization technology, make indissoluble or be slightly soluble in the effective ingredient of water, through cell wall breaking, the bioavailability of medicine can be significantly improved, and consumption is only equivalent to 1/10th of former prescription dosage, thus greatly saves herb resource.
(4) infantum tetanus that the present invention obtains stability of faling apart is high, and toxicity is little, is convenient to take, and bioavailability is high, and its preparation method is simple, does not need any special installation, is applicable to suitability for industrialized production.
Detailed description of the invention
Embodiment 1
Scorpio 600g Fructus Gleditsiae Abnormalis 1200g Radix Et Rhizoma Rhei 1200g
Radix Angelicae Sinensis 180g Sal Ammoniacus (processing) 60g Semen Crotonis Pulveratum 60g
Cinnabaris 3300g artificial Calculus Bovis 30g
(1) Scorpio, Fructus Gleditsiae Abnormalis, Radix Angelicae Sinensis, Semen Crotonis Pulveratum four Chinese medicine material nano grinder are carried out nanorize pulverizing, grinding time is 1 hour, and particle diameter is 200nm, for subsequent use.
(2) described Cinnabaris is removed scrap iron removing, put in ball mill pulverizing tank, add medical material weight 5 times of water simultaneously, under rotating speed is 320rpm condition, waterproof pulverization is carried out to Cinnabaris and obtain suspension in 60 minutes, take out, suspension is proceeded to sucking filtration in sand formula nutsch filter, then proceed in centrifuge dewater 30 minutes, taking-up is put in cotton or absorbent paper, proceeds in hot air circulation case and is drying to obtain under 40 DEG C of conditions.
(3) put in pressure cooker by Radix Et Rhizoma Rhei, add the steaming and decocting of 8 times of weight yellow wine, setting-up time is 120 DEG C, and the time is 2h, takes out Radix Et Rhizoma Rhei and dry at heated-air circulation oven after steaming and decocting, and temperature is 55 DEG C, and the time is 4h, dries.
(4) by Sal Ammoniacus, artificial Calculus Bovis's porphyrize again with above-mentioned medicated powder by " equivalent progressively increase method " facing-up, send into three-dimensional mixer and always mix, incorporation time about 30 minutes, obtain infantile neonatal tetanus and fall apart.
Embodiment 2
Scorpio 600g Fructus Gleditsiae Abnormalis 1200g Radix Et Rhizoma Rhei 1200g
Radix Angelicae Sinensis 180g Sal Ammoniacus (processing) 60g Semen Crotonis Pulveratum 60g
Cinnabaris 3300g artificial Calculus Bovis 30g
(1) Scorpio, Fructus Gleditsiae Abnormalis, Radix Angelicae Sinensis, Semen Crotonis Pulveratum four taste nano grinder carry out nanorize pulverizing, and grinding time is 1 hour, and particle diameter is 200nm, for subsequent use.
(2) described Cinnabaris is removed scrap iron removing, put in ball mill pulverizing tank, add medical material weight 3 times of water simultaneously, under rotating speed is 320rpm condition, waterproof pulverization is carried out to Cinnabaris and obtain suspension in 60 minutes, take out, suspension is proceeded to sucking filtration in sand formula nutsch filter, proceed to again in centrifuge and dewater 50 minutes, take out, put in cotton or absorbent paper, proceed in hot air circulation case and be drying to obtain under 40 DEG C of conditions.
(3) put in pressure cooker by Radix Et Rhizoma Rhei, add the steaming and decocting of 8 times of weight yellow wine, setting-up time is 110 DEG C, and the time is 2.5h, takes out Radix Et Rhizoma Rhei and dry at heated-air circulation oven after steaming and decocting, and temperature is 50 DEG C, and the time is 3.5h, dries.
(4) by Sal Ammoniacus, artificial Calculus Bovis's porphyrize again with above-mentioned medicated powder by " equivalent progressively increase method " facing-up, send into three-dimensional mixer and always mix, incorporation time about 30 minutes, obtain infantile neonatal tetanus and fall apart.
Comparative example 1
Scorpio 600g Fructus Gleditsiae Abnormalis 1200g Radix Et Rhizoma Rhei 1200g
Radix Angelicae Sinensis 180g Sal Ammoniacus (processing) 60g Semen Crotonis Pulveratum 60g
Cinnabaris 3300g artificial Calculus Bovis 30g
(1) Scorpio, Fructus Gleditsiae Abnormalis, Radix Angelicae Sinensis, Semen Crotonis Pulveratum four taste nano grinder carry out nanorize pulverizing, and grinding time is 1 hour, and particle diameter is 200nm, for subsequent use.
(2) Cinnabaris is suitably broken, puts in dosing still, adds proper amount of clear water, grind to form pasty state, then adds water gaging stirring, and namely coarse grain sinks, and inclining immediately suspension, and the coarse grain of sinking grinds again, and repeatable operation like this, to porphyrize.Finally can not the impurity of suspendible discard.Suspension anteversion and retroversion gone out merges standing, and after to be precipitated, the clear water inclined above, grinds to form superfine powder by dry sediment, crosses 200 mesh sieves.
(3) put in pressure cooker by Radix Et Rhizoma Rhei, add the steaming and decocting of 8 times of weight yellow wine, setting-up time is 120 DEG C, and the time is 2h, and take out Radix Et Rhizoma Rhei and dry at heated-air circulation oven, temperature is 55 DEG C, and the time is 4h, dries.
(4) by Sal Ammoniacus, artificial Calculus Bovis's porphyrize again with above-mentioned medicated powder by " equivalent progressively increase method " facing-up, send into three-dimensional mixer and always mix, incorporation time about 30 minutes, obtain infantile neonatal tetanus and fall apart.
Comparative example 2
Scorpio 600g Fructus Gleditsiae Abnormalis 1200g Radix Et Rhizoma Rhei 1200g
Radix Angelicae Sinensis 180g Sal Ammoniacus (processing) 60g Semen Crotonis Pulveratum 60g
Cinnabaris 3300g artificial Calculus Bovis 30g
(1) Scorpio, Fructus Gleditsiae Abnormalis, Radix Et Rhizoma Rhei, Radix Angelicae Sinensis, Semen Crotonis Pulveratum five tastes nano grinder carry out nanorize pulverizing, and grinding time is 1 hour, and particle diameter is 200nm, for subsequent use.
(2) Cinnabaris removing impurity, pulverize in Place grinding machine, be that 1:2 grinds 60 minutes altogether in Cinnabaris and water ratio, to becoming suspension, taking out, suspension being proceeded to sucking filtration in sand formula nutsch filter, proceed to again in centrifuge and dewater 30 minutes, take out, put in cotton or absorbent paper, proceed in hot air circulation case and be drying to obtain under 40 DEG C of conditions.
(3) by Sal Ammoniacus, artificial Calculus Bovis's porphyrize again with above-mentioned medicated powder by " equivalent progressively increase method " facing-up, send into three-dimensional mixer and always mix, incorporation time about 30 minutes, obtain infantile neonatal tetanus and fall apart.
Comparative example 3
Scorpio 600g Fructus Gleditsiae Abnormalis 1200g Radix Et Rhizoma Rhei 1200g
Radix Angelicae Sinensis 180g Sal Ammoniacus (processing) 60g Semen Crotonis Pulveratum 60g
Cinnabaris 3300g artificial Calculus Bovis 30g
(1) Scorpio, Fructus Gleditsiae Abnormalis, Radix Et Rhizoma Rhei, Radix Angelicae Sinensis, Semen Crotonis Pulveratum four taste carry out nano-pulverization, cross 100 mesh sieves.
(2) Cinnabaris is suitably broken, puts in dosing still, adds proper amount of clear water, grind to form pasty state, then adds water gaging stirring, and namely coarse grain sinks, and inclining immediately suspension, and the coarse grain of sinking grinds again, and repeatable operation like this, to porphyrize.Finally can not the impurity of suspendible discard.Suspension anteversion and retroversion gone out merges standing, and after to be precipitated, the clear water inclined above, grinds to form superfine powder by dry sediment, crosses 100 mesh sieves.
(3) by Sal Ammoniacus, artificial Calculus Bovis's porphyrize again with above-mentioned medicated powder by " equivalent progressively increase method " facing-up, send into three-dimensional mixer and always mix, incorporation time about 30 minutes, obtain infantile neonatal tetanus and fall apart.
Infantile neonatal tetanus embodiment 1 ~ 2 and comparative example 1 ~ 3 obtained respectively is loose carries out stability test, the method of accelerated test is adopted to carry out study on the stability to it, temperature 28 DEG C ~ 32 DEG C, relative humidity 55% ~ 65% condition accelerates placement 6 months, carry out quality inspection by " Chinese Pharmacopoeia " version one in 2010, concrete assay is as table 1.
Table 1: the accelerated test result that infantile neonatal tetanus is loose
As shown in Table 1, infantile neonatal tetanus of the present invention falls apart steady quality, especially long-term stability test result shows that the changes of contents of Cinnabaris is less, effectively ensure that the safety of medication, and not easily there is agglomeration, due to the special nature that infantile neonatal tetanus is loose, stability is even more important, therefore the present invention meets production requirement.
Cinnabaris toxicity research
Do the mice tested for medical science, according to the different concocting method of Cinnabaris, carry out toxicity test with the cinnabar powder that embodiment 1 and comparative example 3 concocting method obtain.
Get 20 mices, male and female half and half, be divided into 2 groups at random by weight, sex, often organize 10 animals.Under the condition of room temperature 18 ~ 22 DEG C, before experiment, water 12h is can't help in fasting, and mice tank stomach amount is 0.2ml10g
-1.From dosage in the middle of experiment, give the medicinal liquid of mice various dose.Continuous Observation 7 days after administration, records mouse toxicity reaction, death toll and dead state day by day, the results are shown in Table 2.
Table 2 Cinnabaris toxin is tested
As shown in Table 2, the Cinnabaris flying preparation method obtained by ball milling water is lower than common Cinnabaris toxicity.
Radix Et Rhizoma Rhei discharge function is studied
Do the mice tested for medical science, according to the different concocting method of Radix Et Rhizoma Rhei, the Radix Et Rhizoma Rhei powder obtained with embodiment 1 and the Radix Et Rhizoma Rhei (abbreviation Radix Et Rhizoma Rhei) directly ground carry out rushing down lower experiment.
Get 20 mices, male and female half and half, be divided into 2 groups at random by weight, sex, often organize 10 animals.Gavage Radix Et Rhizoma Rhei powder and Radix Et Rhizoma Rhei that embodiment 1 obtains respectively, 0.5ml/ only.Observe the defecation frequency in each Mus 6 hours.
Consequently: the Radix Et Rhizoma Rhei powder that Radix Et Rhizoma Rhei and embodiment 1 obtain all upon administration 3 hours produces discharge function, the defecation frequency of Radix Et Rhizoma Rhei in 6 hours is 5 times, and the defecation frequency of Radix Et Rhizoma Rhei of the present invention in 6 hours is 2 times, lower time and passage of loose stools number of times and total defecation frequency all slightly postpone from rushing down and reduces (P < 0.05), therefore the property of medicine of the present invention is gentle, be applicable to child administration.
Below in conjunction with clinical laboratory data, beneficial effect of the present invention is described:
Subjects is neonatal infantum tetanus case patient; Observe case 120 example.
Treatment group: fall apart with the nano children's infantum tetanus that inventive embodiments 1 method is obtained, oral, one time 0.075 gram.
Contrast groups: infantile neonatal tetanus falls apart (Xi'an Zili Traditional Chinese Medicine Group Co., Ltd.), oral, one time 0.075 gram, result of the test is in table 3.
Table 3 infantile neonatal tetanus falls apart clinical test results
| Group | Total number of cases | Recovery from illness | Effective | Effectively | Invalid | Total effectively example |
| Treatment group | 80 | 72(90％) | 3(3.8％) | 4(5％) | 1(1.2％) | 98.8％ |
| Matched group | 40 | 30(75％) | 2(5％) | 3(7.5％) | 5(5％) | 95％ |
As shown in Table 3, the infantile neonatal tetanus adopting preparation method of the present invention to obtain falls apart the uneasiness of crying caused nascent children's's tire fire interior-heat, cough with copious phlegm, the effective percentage of constipation etc. is more than 98.8%, visible, adopt method of the present invention to not only reduce toxicity, also improve drug effect.
Claims (8)
1. the preparation method that nano children's infantum tetanus is loose, is characterized in that, comprise the following steps:
(1) Scorpio, Fructus Gleditsiae Abnormalis, Radix Angelicae Sinensis and Semen Crotonis Pulveratum four Chinese medicine material nano grinder are carried out nanorize pulverizing and obtain nano powder;
(2) adopt ball milling elutriation to concoct Cinnabaris, drying and screening, obtains cinnabar powder;
The process of described ball milling elutriation is as follows: by Cinnabaris except scrap iron removing, put in ball mill pulverizing tank, add medical material weight 3 ~ 5 times of water simultaneously, under rotating speed is 250 ~ 400rpm condition, waterproof pulverization is carried out to Cinnabaris and obtain suspension in 30 ~ 60 minutes, then through the powdery solid that sucking filtration, centrifuge dehydration obtain, in hot air circulation case, further drying obtains cinnabar powder;
(3) adopt yellow wine to concoct Radix Et Rhizoma Rhei, drying and screening, obtains Radix Et Rhizoma Rhei powder;
(4) by Sal Ammoniacus and artificial Calculus Bovis's porphyrize, the nano powder obtained with step (1) ~ (3), cinnabar powder and Radix Et Rhizoma Rhei powder facing-up, sieve, mix, obtain described nano children's infantum tetanus and fall apart.
2. the preparation method that nano children's infantum tetanus according to claim 1 is loose, it is characterized in that, the weight portion of medical material used is as follows:
Scorpio 500 ~ 800 parts of Fructus Gleditsiae Abnormalis 1000 ~ 1500 parts of Radix Et Rhizoma Rhei 1000 ~ 1500 parts
Radix Angelicae Sinensis 150 ~ 200 parts of Sal Ammoniacuss 50 ~ 100 parts of Semen Crotonis Pulveratums 50 ~ 100 parts
Cinnabaris 3000 ~ 3500 parts of artificial Calculus Boviss 20 ~ 50 parts.
3. the preparation method that nano children's infantum tetanus according to claim 1 is loose, is characterized in that, in step (1), the time that nanorize is pulverized is 0.5 ~ 6 hour, and the mean diameter of the nano powder obtained is 100 ~ 300nm.
4. the preparation method that nano children's infantum tetanus according to claim 3 is loose, is characterized in that, the time that nanorize is pulverized is 1 hour, and the mean diameter of the nano powder obtained is 200nm.
5. the preparation method that nano children's infantum tetanus according to claim 1 is loose, it is characterized in that, in step (2), baking temperature is 30 ~ 50 DEG C.
6. the preparation method that nano children's infantum tetanus according to claim 1 is loose, it is characterized in that, in step (3), Radix Et Rhizoma Rhei is adopted and is concocted with the following method: put by Radix Et Rhizoma Rhei in pressure cooker, add the steaming and decocting of 8 ~ 10 times of weight yellow wine, design temperature is 100 ~ 130 DEG C, and the time is 1.5 ~ 2.5h, after steaming and decocting completes, taking-up Radix Et Rhizoma Rhei is dried at heated-air circulation oven, obtains described Radix Et Rhizoma Rhei powder.
7. the preparation method that nano children's infantum tetanus according to claim 6 is loose, it is characterized in that, bake out temperature is 40 ~ 60 DEG C, and drying time is 3 ~ 5h.
8. a nano children's infantum tetanus is fallen apart, and it is characterized in that, is prepared by the preparation method described in any one of claim 1 ~ 7.
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