CN101912415A - Method for processing cinnabar powder Chinese medicinal tablets - Google Patents

Abstract

The invention discloses a method for processing cinnabar powder Chinese medicinal tablets, which comprises the following steps of: (1) cleaning: taking a raw medicinal material, removing impurities, putting the material into a magnetic separator, attracting scrap iron, putting the material into a clean container, stirring and washing the material with clean water, and filtering the mixture in a sand filter; (2) transferring the filtered cinnabar into a ball milling crusher, taking magnetic balls as a crushing medium, meanwhile adding clean water into the crusher in a volume ratio of the cinnabar to the water of 1:2, grinding the mixture for 60 minutes till forming suspension, and taking the suspension out; and (3) transferring the suspension into the sand filter to perform filtration, then transferring the filtrate to a centrifuge to perform dehydration for 30 minutes, taking the dehydrated product out, placing the dehydrated product on cotton cloth or water absorption paper, transferring the cotton cloth or the water absorption paper to a hot air circulating box and drying the dehydrated product at the temperature of 40 DEG C to obtain a product. The method has the advantages of shortening the production time, improving the production efficiency, reducing the production place and the labor force, greatly saving the production cost, easily controlling the production process, realizing automation, scale and normalization of processing, facilitating environmental protection and sanitation management and improving the purity of a medicament.

Description

The concocting method of the Cinnabaris powder prepared slices of Chinese crude drugs

[technical field]

The present invention relates to the concocting method of Chinese crude drug, more particularly, is the concocting method of Cinnabaris decoction pieces.

[background technology]

Cinnabaris is trigonal system mineral cinnabar Cinnabar, main Containing Sulfur hydrargyrum (HgS).After excavating, choose pure person, with the Magnet ferruginous impurity that exhausts, water is washed in a pan roguing stone and silt particle again.The Cinnabaris sweet in the mouth, cold nature; Poisonous.The GUIXIN warp.Has relieving convulsion, the antidotal function of calming the nerves that clears away heart-fire.After flying, water can make medicine reach pure, and superfine, be convenient to preparation and take.Take orally and be used for palpitation and being susceptible to fright, insomnia and dreamful sleep, epilepsy toxic swelling etc. more.As Cinnabar Sedative Pill, Pill of Magnetitum and Cinnabari, zijin troche.

Its traditional concocting method is: get crude drug, exhaust iron filings with Magnet, put in the mortar, add proper amount of clear water and grind to form pasty state, add the volume clear water then and stir, incline and get suspension.The coarse powder that sinks is gone up method for another example, and repeatable operation is repeatedly twisted with the fingers exquisiteness until hands, till the no bright star, discards impurity, merges suspension, leaves standstill hypsokinesis and removes top clear water, gets precipitation and dries, and porphyrize gets final product again.

[summary of the invention]

Technical problem to be solved by this invention is to provide a kind of concocting method of Cinnabaris powder decoction pieces; can improve the pharmaceutical purity cleanliness; make medicine fine and smooth more, be convenient to for oral administration and external, simultaneously; can reduce the toxicity of medicine; avoid medicine dust from flying in process of lapping, the protection environment, this method is suitable for large-scale production; not only saved medicine production cost and production site also improved production efficiency greatly.

The present invention solves the problems of the technologies described above by the following technical programs: the concocting method of Cinnabaris powder decoction pieces, take following steps:

Get crude drug, remove impurity, put in the magnetic separator, exhaust iron filings, put in the clean container clear water washing and filtering;

Filterable Cinnabaris changes in the pulverizer, and (volume ratio is about Cinnabaris: water=1: 2), ground altogether 30 minutes, to becoming suspension, take out to add clean water simultaneously.

C. suspension is put sucking filtration in the nutsch filter, changed in the centrifuge over to dehydration 30 minutes again, take out, change in the hot air circulation case dry getting final product under 40 ℃ of conditions over to.

Principle of the present invention is:

Impurity in the Cinnabaris mainly is free mercury and solubility mercury salt, latter's toxicity is very big, be the main toxic component in the Cinnabaris, concoct that the method for present domestic processing Cinnabaris powder has driedly grinds method, adds water polishing and grinding water flying method based on " porphyrize " and " water flies " method.With physical arrangement, particle diameter, mercury content and impurity content is index, and to the analysis result demonstration of Cinnabaris processed goods, porcelain alms bowl elutriation quality is good, and efficient is lower; The dried method (ball-milling method) of grinding that adopts in big production the, its free mercury content are higher than more than 300 ten thousand times of country's drinking-water water supply standards up to 3028 μ g/g.Also discover, when producing greatly, dried method free mercury content 68.7ppm, the solubility mercury salt 32.2ppm of grinding; Grinding water flying method free mercury content 27.6ppm, solubility mercury salt 8.4ppm.Therefore, the grinding water flying method is comparatively ideal concocting method.Studies confirm that further water flies to make Cinnabaris toxic mercury content to descend, and also can reduce the content of metals such as plumbous and ferrum.It is many more to wash major's number of times when water flies, and the content of solubility mercury salt is few more, and HgS content is not had influence substantially.Find in addition, shine the dry product middle reaches and exceed about 1 times than 60 ℃ of oven dry persons, so after water flies that the Cinnabaris powder should air dried tradition be concocted and required have the science reason from the content of hydrargyrum.

So main thought of the present invention is: traditional elutriation is not only time-consuming but also require great effort, and labor efficiency is low, the incompatibility mass production; And ball-milling method is in other worker's process, as cause the reduction of hydrargyrum in the cinnabar in pulverizing with Metal Contact such as ferrum or heating etc., its free mercury increased than the free mercury content in the tcrude ore; The porcelain ball mill adds water and flies to grind Cinnabaris, can increase work efficiency, and reduces labor intensity, and can reduce to bottom line to the toxicity of Cinnabaris again.

The invention has the advantages that:

(1) shortens the production time, improved production efficiency.Usually need 30 days if adopt traditional water to fly explained hereafter 200kg Cinnabaris powder, and new technology only needs 8 hours, has improved production efficiency greatly.

(2) reduce production place and labour force, saved production cost greatly.Traditional handicraft need take mass production place and labour force when producing, and relies on manual operations fully, and new technology automaticity height occupies little space, and is time saving and energy saving.

(3) production process is easy to control, has realized automatization, scale and the standardization of concocting.New technology adopts mechanized operation, as: pulverizer, centrifuge, traditional handicraft then adopt a large amount of vessels, and it is big to take up room, and are not easy to control and operation.

(4) help environmental conservation, made things convenient for administration of health.The traditional handicraft open type is produced, and pollutes production environment, is difficult to cleaning.The closed production of new technology is difficult for producing dirt, has avoided pollution, helps cleaning and environmental conservation.

(5) purity of raising medicine has reduced drug toxicity, guarantees the quality safety of product.

[specific embodiment]

Raw material and finished product detection: according to the source and the physicochemical property of Cinnabaris, quality control is carried out in its safety and effectiveness index, guarantee product quality from the source.As control to iron salt, free mercury and assay thereof in the Cinnabaris, guarantee the raw materials quality of throwing stable, controlled.

Concocting process is as follows:

(1) clean system: get crude drug, remove impurity, put in the magnetic separator, exhaust iron filings, put in the clean container, the clear water agitator treating is put sucking filtration in the sand filter;

(2) filterable Cinnabaris changes in the Baily ball mill pulverizer, and crushing medium is the magnetic ball, and (volume ratio is about Cinnabaris: water=1: 2), ground altogether 60 minutes, to becoming suspension, take out to add clean water simultaneously in proportion.

(3) suspension is changed over to sucking filtration in the sand formula nutsch filter, change in the centrifuge dehydration 30 minutes again over to, take out, put in cotton or the absorbent paper, change in the hot air circulation case dry getting final product under 40 ℃ of conditions over to.

The present invention has reduced production link, has saved production site and washing time, has both shortened the production cycle, but line production again.Owing in pulverizing, dehydration, drying process, adopted the mechanization hands-off operation, make the whole production time shorten greatly, avoided secondary pollution, guaranteed drug quality, improved working environment simultaneously greatly.Because process of manufacture is controlled, can guarantee once to produce up-to-standard Cinnabaris powder, has both saved production cost, has shortened the production cycle, has improved production efficiency again, has saved the energy.

Though more than described the specific embodiment of the present invention; but being familiar with those skilled in the art is to be understood that; our described specific embodiment is illustrative; rather than be used for qualification to scope of the present invention; those of ordinary skill in the art are in the modification and the variation of the equivalence of doing according to spirit of the present invention, all should be encompassed in the scope that claim of the present invention protects.

Claims (1)

1. the concocting method of Cinnabaris powder prepared slices of Chinese crude drugs is characterized in that: comprise the steps:

(1) clean system: get crude drug, remove impurity, put in the magnetic separator, exhaust iron filings, put in the clean container, the clear water agitator treating is put sucking filtration in the sand filter;

(2) filterable Cinnabaris changes in the ball mill pulverizer, and crushing medium is the magnetic ball, adds clean water in proportion simultaneously, and the volume ratio of Cinnabaris and water is 1: 2, grinds altogether 60 minutes, to becoming suspension, takes out;

(3) suspension is changed over to sucking filtration in the sand formula nutsch filter, change in the centrifuge dehydration 30 minutes again over to, take out, put in cotton or the absorbent paper, change in the hot air circulation case dry getting final product under 40 ℃ of conditions over to.