CN101912415B - Method for processing cinnabar powder Chinese medicinal tablets - Google Patents
Method for processing cinnabar powder Chinese medicinal tablets Download PDFInfo
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- CN101912415B CN101912415B CN 201010249335 CN201010249335A CN101912415B CN 101912415 B CN101912415 B CN 101912415B CN 201010249335 CN201010249335 CN 201010249335 CN 201010249335 A CN201010249335 A CN 201010249335A CN 101912415 B CN101912415 B CN 101912415B
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- cinnabar
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- 238000000034 method Methods 0.000 title claims abstract description 27
- 229910052956 cinnabar Inorganic materials 0.000 title claims abstract description 18
- 239000000843 powder Substances 0.000 title claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 29
- 239000003814 drug Substances 0.000 claims abstract description 15
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000000725 suspension Substances 0.000 claims abstract description 11
- 238000001914 filtration Methods 0.000 claims abstract description 8
- 239000012535 impurity Substances 0.000 claims abstract description 8
- 229910052742 iron Inorganic materials 0.000 claims abstract description 6
- 239000004576 sand Substances 0.000 claims abstract description 6
- 230000018044 dehydration Effects 0.000 claims abstract description 5
- 238000006297 dehydration reaction Methods 0.000 claims abstract description 5
- 229920000742 Cotton Polymers 0.000 claims abstract description 4
- 239000006148 magnetic separator Substances 0.000 claims abstract description 4
- 229940079593 drug Drugs 0.000 claims description 8
- 230000008859 change Effects 0.000 claims description 5
- 239000012467 final product Substances 0.000 claims description 4
- 229910052573 porcelain Inorganic materials 0.000 claims description 4
- 230000002745 absorbent Effects 0.000 claims description 2
- 239000002250 absorbent Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 26
- 239000000047 product Substances 0.000 abstract description 8
- 238000000227 grinding Methods 0.000 abstract description 6
- 238000000498 ball milling Methods 0.000 abstract description 3
- 230000007613 environmental effect Effects 0.000 abstract description 3
- 238000005406 washing Methods 0.000 abstract description 3
- 238000004140 cleaning Methods 0.000 abstract description 2
- 238000001035 drying Methods 0.000 abstract description 2
- 238000003756 stirring Methods 0.000 abstract description 2
- 239000000463 material Substances 0.000 abstract 4
- 238000010521 absorption reaction Methods 0.000 abstract 2
- 239000004744 fabric Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000000706 filtrate Substances 0.000 abstract 1
- 238000010606 normalization Methods 0.000 abstract 1
- 238000004904 shortening Methods 0.000 abstract 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 10
- 229910052753 mercury Inorganic materials 0.000 description 9
- 238000005516 engineering process Methods 0.000 description 6
- 150000002730 mercury Chemical class 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 206010010904 Convulsion Diseases 0.000 description 1
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 206010070863 Toxicity to various agents Diseases 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 230000003749 cleanliness Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 150000002505 iron Chemical class 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- QXKXDIKCIPXUPL-UHFFFAOYSA-N sulfanylidenemercury Chemical compound [Hg]=S QXKXDIKCIPXUPL-UHFFFAOYSA-N 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a method for processing cinnabar powder Chinese medicinal tablets, which comprises the following steps of: (1) cleaning: taking a raw medicinal material, removing impurities, putting the material into a magnetic separator, attracting scrap iron, putting the material into a clean container, stirring and washing the material with clean water, and filtering the mixture in a sand filter; (2) transferring the filtered cinnabar into a ball milling crusher, taking magnetic balls as a crushing medium, meanwhile adding clean water into the crusher in a volume ratio of the cinnabar to the water of 1:2, grinding the mixture for 60 minutes till forming suspension, and taking the suspension out; and (3) transferring the suspension into the sand filter to perform filtration, then transferring the filtrate to a centrifuge to perform dehydration for 30 minutes, taking the dehydrated product out, placing the dehydrated product on cotton cloth or water absorption paper, transferring the cotton cloth or the water absorption paper to a hot air circulating box and drying the dehydrated product at the temperature of 40 DEG C to obtain a product. The method has the advantages of shortening the production time, improving the production efficiency, reducing the production place and the labor force, greatly saving the production cost, easily controlling the production process, realizing automation, scale and normalization of processing, facilitating environmental protection and sanitation management and improving the purity of a medicament.
Description
[technical field]
The present invention relates to the concocting method of Chinese crude drug, more particularly, is the concocting method of Cinnabaris decoction pieces.
[background technology]
Cinnabaris is trigonal system mineral cinnabar Cinnabar, main Containing Sulfur hydrargyrum (HgS).After excavating, choose pure person, with the impurity of Magnet exhaustion iron content, then water is washed in a pan roguing stone and silt particle.The Cinnabaris sweet in the mouth, cold nature; Poisonous.The GUIXIN warp.Has the function relieving convulsion, the detoxifcation of calming the nerves that clears away heart-fire.After flying, water can make medicine reach pure, and superfine, be convenient to preparation and take.For oral administration multiplex in palpitation and being susceptible to fright, insomnia and dreamful sleep, epilepsy toxic swelling etc.As Cinnabar Sedative Pill, Pill of Magnetitum and Cinnabari, zijin troche.
Its traditional concocting method is: get crude drug, exhaust iron filings with Magnet, put in mortar, add proper amount of clear water and grind to form pasty state, then add the volume clear water and stir, incline and get suspension.The coarse powder that sinks is gone up method for another example, and repeatable operation repeatedly until hands is twisted with the fingers exquisiteness, till bright star, discards impurity, merges suspension, and top clear water is removed in standing hypsokinesis, get precipitation and dry, then porphyrize gets final product.
[summary of the invention]
Technical problem to be solved by this invention is to provide a kind of concocting method of cinnabar powder decoction pieces; can improve the pharmaceutical purity cleanliness; make medicine finer and smoother, be convenient to for oral administration and external, simultaneously; can reduce the toxicity of medicine; avoid medicine dust from flying in process of lapping, protection of the environment, this method is suitable for large-scale production; not only saved medicine production cost and production site also improved production efficiency greatly.
The present invention solves the problems of the technologies described above by the following technical programs: the concocting method of cinnabar powder decoction pieces, take following steps:
Get crude drug, remove impurity, put in magnetic separator, exhaust iron filings, put in clean container the clear water washing and filtering;
The Cinnabaris that filters changes in pulverizer, and (volume ratio is about Cinnabaris: water=1: 2), ground altogether 30 minutes, to becoming suspension, take out to add simultaneously clean water.
C. suspension is put sucking filtration in nutsch filter, then changed in centrifuge over to dehydration 30 minutes, take out, change in the hot air circulation case dry getting final product under 40 ℃ of conditions over to.
Principle of the present invention is:
Impurity in Cinnabaris is mainly free mercury and solubility mercury salt, latter's toxicity is very big, be the main toxic component in Cinnabaris, concoct take " porphyrize " and " water flies " method as main, the method for present domestic processing cinnabar powder has driedly grinds method, adds water polishing and grinding water flying method.Take physical arrangement, particle diameter, mercury content and impurity content as index, to the analysis result demonstration of Cinnabaris processed goods, porcelain alms bowl elutriation quality is good, and efficient is lower; The dried method (ball-milling method) of grinding that adopts in large production, its free mercury content are up to 3028 μ g/g, higher than more than 300 ten thousand times of country's drinking-water water supply standards.Also there is research to find, when producing greatly, dried method free mercury content 68.7ppm, the solubility mercury salt 32.2ppm of grinding; Grinding water flying method free mercury content 27.6ppm, solubility mercury salt 8.4ppm.Therefore, the grinding water flying method is comparatively ideal concocting method.Further studies confirm that, water flies to make Cinnabaris toxic mercury content to descend, and also can reduce the content of the metals such as plumbous and ferrum.Wash major's number of times when water flies more, the content of solubility mercury salt is fewer, and on HgS content substantially without the impact.Find in addition, shine dry product middle reaches and exceed approximately 1 times from Hg content than 60 ℃ of oven dry persons, so after water flew, the tradition that cinnabar powder should dry was concocted and required to have the science reason.
So main thought of the present invention is: traditional elutriation is not only time-consuming but also require great effort, and labor efficiency is low, inadaptable a large amount of production; And ball-milling method is in another work process, the reduction of hydrargyrum in cinnabar makes its free mercury than the free mercury increased content in tcrude ore as causing with the Metal Contact such as ferrum or heating etc. in pulverizing; The porcelain ball mill adds water and flies to grind Cinnabaris, can increase work efficiency, and reduces labor intensity, and can be down to bottom line to the toxicity of Cinnabaris again.
The invention has the advantages that:
(1) shorten the production time, improved production efficiency.Usually need 30 days if adopt traditional water to fly explained hereafter 200kg cinnabar powder, and new technology only needs 8 hours, has greatly improved production efficiency.
(2) reduce Workplace and labour force, greatly saved production cost.Traditional handicraft need to take a large amount of Workplaces and labour force when producing, and relies on manual operations fully, and the new technology automaticity is high, occupies little space, and is time saving and energy saving.
(3) production process is easy to control, and has realized automatization, scale and the standardization of concocting.New technology adopts mechanized operation, as: pulverizer, centrifuge, traditional handicraft adopt a large amount of container tools, take up room large, are not easy to control and operation.
(4) be conducive to environmental conservation, facilitated administration of health.The traditional handicraft open type is produced, and pollutes production environment, is difficult to cleaning.The closed production of new technology is difficult for producing dirt, has avoided pollution, is conducive to clean and environmental conservation.
(5) improve the purity of medicine, reduced drug toxicity, guarantee the quality safety of product.
[specific embodiment]
Raw material and finished product detection: according to source and the physicochemical property of Cinnabaris, quality control is carried out in its safety and Validity Index, guarantee product quality from the source.As the control to iron salt, free mercury and assay thereof in Cinnabaris, guarantee the raw materials quality of throwing stable, controlled.
Concocting process is as follows:
(1) clean system: get crude drug, remove impurity, put in magnetic separator, exhaust iron filings, put in clean container, the clear water agitator treating is put sucking filtration in sand filter;
(2) Cinnabaris that filters changes in the Baily ball mill pulverizer, and crushing medium is porcelain ball, and (volume ratio is about Cinnabaris: water=1: 2), ground altogether 60 minutes, to becoming suspension, take out to add in proportion clean water simultaneously.
(3) suspension is changed over to sucking filtration in sand formula nutsch filter, then change in centrifuge dehydration 30 minutes over to, take out, put in cotton or absorbent paper, change in the hot air circulation case dry getting final product under 40 ℃ of conditions over to.
The present invention has reduced production link, has saved production site and washing time, has both shortened the production cycle, but line production again.Due in pulverizing, dehydration, drying process, adopted the mechanization hands-off operation, make the whole production time greatly shorten, avoided secondary pollution, guaranteed drug quality, greatly improved working environment simultaneously.Controlled due to process of manufacture can guarantee once to produce up-to-standard cinnabar powder, both saved production cost, shortened the production cycle, improved again production efficiency, saved the energy.
Although more than described the specific embodiment of the present invention; but being familiar with those skilled in the art is to be understood that; our described specific embodiment is illustrative; rather than for the restriction to scope of the present invention; those of ordinary skill in the art are in modification and the variation of the equivalence of doing according to spirit of the present invention, all should be encompassed in the scope that claim of the present invention protects.
Claims (1)
1. the concocting method of cinnabar powder prepared slices of Chinese crude drugs, is characterized in that: comprise the steps:
(1) clean system: get crude drug, remove impurity, put in magnetic separator, exhaust iron filings, put in clean container, the clear water agitator treating is put sucking filtration in sand filter;
(2) Cinnabaris that filters changes in ball mill pulverizer, and crushing medium is porcelain ball, and adding in proportion clean water, the volume ratio of Cinnabaris and water simultaneously is 1: 2, grinds altogether 60 minutes, to becoming suspension, takes out;
(3) suspension is changed over to sucking filtration in sand formula nutsch filter, then change in centrifuge dehydration 30 minutes over to, take out, put in cotton or absorbent paper, change in the hot air circulation case dry getting final product under 40 ℃ of conditions over to.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010249335 CN101912415B (en) | 2010-08-03 | 2010-08-03 | Method for processing cinnabar powder Chinese medicinal tablets |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010249335 CN101912415B (en) | 2010-08-03 | 2010-08-03 | Method for processing cinnabar powder Chinese medicinal tablets |
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| Publication Number | Publication Date |
|---|---|
| CN101912415A CN101912415A (en) | 2010-12-15 |
| CN101912415B true CN101912415B (en) | 2013-06-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201010249335 Active CN101912415B (en) | 2010-08-03 | 2010-08-03 | Method for processing cinnabar powder Chinese medicinal tablets |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104474038B (en) * | 2014-12-25 | 2017-06-13 | 海南葫芦娃药业集团股份有限公司 | Nano children's umbilical tetanus dissipate and preparation method thereof |
| CN110448467A (en) * | 2019-08-26 | 2019-11-15 | 北京同仁堂(安国)中药饮片有限责任公司 | A kind of Chinese medicine powder-refining with water method |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1013554B (en) * | 1988-12-14 | 1991-08-21 | 天津市第五中药厂 | Grinding process of cinnabar and pearl |
| CN1853651A (en) * | 2005-03-28 | 2006-11-01 | 兰州大学 | Medicinal composition containing cinnabar or/and realgar |
-
2010
- 2010-08-03 CN CN 201010249335 patent/CN101912415B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1013554B (en) * | 1988-12-14 | 1991-08-21 | 天津市第五中药厂 | Grinding process of cinnabar and pearl |
| CN1853651A (en) * | 2005-03-28 | 2006-11-01 | 兰州大学 | Medicinal composition containing cinnabar or/and realgar |
Non-Patent Citations (2)
| Title |
|---|
| 乌日娜.不同炮制方法对中药朱砂作用的研究进展.《中国民族医药杂志》.2007,(第5期),66-70. * |
| 宋志刚等.朱砂炮制法改进的体会.《时珍国药研究》.1994,第5卷(第2期),30. * |
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| Publication number | Publication date |
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| CN101912415A (en) | 2010-12-15 |
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Effective date of registration: 20190826 Address after: 236800 Bozhou, Wu Wei Road, Anhui, No. 1999 Co-patentee after: Beijing TRT Pharma Co., Ltd. Patentee after: Beijing Tongrentang Group (Bozhou) Herbal Sheet Co., Ltd. Address before: 236800 No. 168 Xieling North Road, Zhechengcheng District, Bozhou City, Anhui Province Patentee before: Beijing Tongrentang Group (Bozhou) Herbal Sheet Co., Ltd. |
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| TR01 | Transfer of patent right |