CN113925052A - Concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant and preparation method thereof - Google Patents
Concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant and preparation method thereof Download PDFInfo
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- CN113925052A CN113925052A CN202010608627.0A CN202010608627A CN113925052A CN 113925052 A CN113925052 A CN 113925052A CN 202010608627 A CN202010608627 A CN 202010608627A CN 113925052 A CN113925052 A CN 113925052A
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- quaternary ammonium
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aliphatically bound aldehyde or keto groups, or thio analogues thereof; Derivatives thereof, e.g. acetals
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention relates to a concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant and a preparation method thereof. The concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant comprises the following components in percentage by weight: 10-30% of glutaraldehyde, 5-20% of decamethylammonium bromide, 5-25% of benzalkonium bromide, 0.1-5% of emulsifier, 0.5-8% of stabilizer and the balance of deionized water. The disinfectant has no pungent smell, good stability, and long-term storage, and can maintain remarkable sterilizing effect, and the killing rate of Escherichia coli, Staphylococcus aureus, Pasteurella multocida, and hemolytic streptococcus can reach 100% at certain concentration. In addition, the product of the invention is a high-concentration disinfectant, can be diluted by multiple times when in use, not only greatly reduces the using amount of packing materials and relieves the pressure of recycling and treating the packing wastes, but also is beneficial to environmental protection and has wide application prospect.
Description
Technical Field
The invention belongs to the technical field of disinfectants for animals, and particularly relates to a concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant and a preparation method thereof.
Background
At present, infectious diseases in a farm are more and more serious under the trend of higher and higher intensification degree, and the problem of controlling animal epidemic diseases is very prominent. The epidemic diseases of the large-scale farm are usually the result of the comprehensive action of multiple factors, but the main cause is the invasion and diffusion of pathogenic microorganisms in the external environment or the pollution and diffusion of pathogenic microorganisms of animals in the farm. Due to the limitations of animal medication and the disadvantages, the important role of disinfectants in the prevention and control of animal epidemic diseases is well recognized. Effective disinfection is one of important measures for stopping and reducing pathogens in the environment of a farm, cutting off epidemic disease transmission ways and preventing and controlling infectious diseases of the farm.
Glutaraldehyde is a commonly used high-efficiency disinfectant, which mainly seals the outer cell layer of bacteria, inactivates cellular enzymes and changes nucleic acid protein structure through alkylation reaction on microbial protein, thereby achieving the effect of killing bacteria and viruses, and has less corrosivity on metal instruments, glass and plastic products, but the storage time of valeraldehyde in an acidic solution is long but the sterilization effect is poor, and the sterilization effect of glutaraldehyde in an alkaline solution is good but the effective period is short. The decamethyl ammonium bromide belongs to a double-chain quaternary ammonium salt compound and is also a common disinfectant component, and can change the permeability of a bacterial cell membrane to ensure that intracellular components permeate outwards to block cell metabolism so as to kill bacteria. But the antibacterial spectrum of the decamethyl ammonium bromide is small, the decamethyl ammonium bromide is easily influenced by external conditions, and the disinfection range is limited. Benzalkonium bromide is a commonly used spectrum bactericide, can change the permeability of bacterial cytoplasmic membranes, has a killing effect by exosmosis of bacterial cytoplasmic substances and blocking the metabolism of the bacterial cytoplasmic substances, has a particularly strong sterilizing capability, but has a weak effect on viruses.
At present, the compound quaternary ammonium salt glutaraldehyde solution in the domestic market has fewer varieties, can kill microbial viruses generally, cannot meet the increasing prevention and control of diseases of large intensive farms at present, and can increase the use requirement of the disinfectant in future breeding industry under the influence of swine fever epidemic situation, so that a plurality of patents of the disinfectant mainly research the compound disinfectant solution, increase the components of raw and auxiliary materials, effectively improve the bacteriostatic effect and stability, and develop the environment-friendly disinfectant without residues and corrosion.
Therefore, the disinfectant which has the advantages of safety, low toxicity, no irritation, good stability and low use cost is provided while ensuring high-efficiency and wide killing effect.
Disclosure of Invention
The invention aims to solve the problems in the prior art and provides a concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant which is efficient, safe, low in toxicity, free of irritation, low in cost and good in stability, and the specific technical scheme is as follows:
the concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant mainly comprises glutaraldehyde, compound quaternary ammonium salt, an emulsifier and a stabilizer, wherein the compound quaternary ammonium salt consists of decamethyl ammonium bromide and benzalkonium bromide.
The concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant comprises the following components in percentage by weight: 10-30% of glutaraldehyde, 5-20% of decamethylammonium bromide, 5-25% of benzalkonium bromide, 0.1-5% of emulsifier, 0.5-8% of stabilizer and the balance of deionized water. Preferably, the concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant comprises the following components in percentage by weight: 15-25% of glutaraldehyde, 5-10% of decamethylammonium bromide, 10-20% of benzalkonium bromide, 1-3% of emulsifier, 1-5% of stabilizer and the balance of deionized water.
The weight ratio of the decamethyl ammonium bromide to the benzalkonium bromide is 1: 1-4, and preferably 1: 3.
The weight ratio of the glutaraldehyde to the compound quaternary ammonium salt is 1: 2-3: 1, and preferably 1: 1.
More preferably, the concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant comprises the following components in percentage by weight: 25% of glutaraldehyde, 6.25% of decamethylammonium bromide, 18.75% of benzalkonium bromide, 2.5% of emulsifier, 3.5% of stabilizer and the balance of deionized water.
The emulsifier is one or more of fatty alcohol polyoxyethylene, lauryl alcohol polyoxyethylene ether and isooctyl polyoxyethylene ether.
The stabilizer is isoamyl acetate.
The preparation method of the concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant specifically comprises the following steps:
(1) weighing the raw material components according to the formula amount, dissolving the emulsifier in hot water at 40-70 ℃, stirring until the emulsifier is completely dissolved, and standing to room temperature.
(2) And (2) dissolving glutaraldehyde, decamethylammonium bromide and benzalkonium bromide in deionized water, adding the solution obtained in the step (1), and continuing stirring until the solution is dissolved.
(3) And (3) adding a stabilizer into the solution obtained in the step (2), and continuously stirring until the stabilizer is completely dissolved to obtain the composite stabilizer.
The concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant can be applied to disinfection of farms, public places and equipment and instruments.
Has the advantages that:
the disinfectant based on concentrated glutaraldehyde-compound quaternary ammonium salt has the following advantages:
(1) compared with a disinfectant compounded by glutaraldehyde and a single quaternary ammonium salt, the disinfectant compounded by glutaraldehyde and two quaternary ammonium salts has the advantages of long disinfection action duration, strong penetrability, safety, no toxicity, no stimulation, no corrosion and dual bactericidal effects on bacteria, viruses and spore pathogens.
(2) The concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant with the preferable formula ratio has good bacteriostatic effects on streptococcus, staphylococcus aureus, pasteurella and haemophilus parasuis, and has the bactericidal rate on the streptococcus of more than 99.8 percent and the bactericidal rate on the other three bacteria of more than 99.9 percent.
(3) The stabilizing agent of the invention can make the disinfectant solution have good dispersibility and can obviously improve the stability of the disinfectant.
(4) This product concentration is higher, can many times dilute during the use, consequently raiser can dilute the back with less product and can act on the plant, not only reduces the manufacturing cost of enterprise by a wide margin, reduces customer's use cost moreover, and the reduction of package material use amount has simultaneously slowly reduced the recovery processing pressure of packing discarded object, does benefit to environmental protection, and application prospect is extensive.
Detailed Description
The technical solutions of the present invention will be described clearly and completely below, and it should be apparent that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention.
Example 1
A concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant contains the following components by weight per 100g of disinfectant: 10g of glutaraldehyde, 5g of decamethylammonium bromide, 5g of benzalkonium bromide, 0.1g of fatty alcohol polyoxyethylene, 0.5g of isoamyl acetate and the balance of deionized water.
Example 2
A concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant contains the following components by weight per 100g of disinfectant: 30g of glutaraldehyde, 20g of decamethylammonium bromide, 25g of benzalkonium bromide, 5g of polyoxyethylene lauryl ether, 8g of isoamyl acetate and the balance of deionized water.
Example 3
A concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant contains the following components by weight per 100g of disinfectant: 20g of glutaraldehyde, 5g of decamethylammonium bromide, 15g of benzalkonium bromide, 2g of isooctyl polyoxyethylene ether, 2.5g of isoamyl acetate and the balance of deionized water.
Example 4
A concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant contains the following components by weight per 100g of disinfectant: 25g of glutaraldehyde, 6.25g of decamethylammonium bromide, 18.75g of benzalkonium bromide, 2.5g of fatty alcohol polyoxyethylene, 3.5g of isoamyl acetate and the balance of deionized water.
The preparation method of the concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant in the embodiment 1-4 comprises the following steps:
(1) weighing the raw material components according to the formula amount, dissolving the emulsifier in hot water at 40-70 ℃, stirring until the emulsifier is completely dissolved, and standing to room temperature.
(2) And (3) dissolving glutaraldehyde, decamethylammonium bromide and benzalkonium bromide in deionized water, adding the solution prepared in the step (1), and continuously stirring until the solution is dissolved.
(3) And (3) adding the stabilizer into the solution prepared in the step (2), and continuously stirring until the stabilizer is completely dissolved to obtain the concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant.
Example 5 detection of Compound Quaternary ammonium salt Bactericidal Effect
1. Comparison of the Effect of glutaraldehyde-Compound Quaternary ammonium salt disinfectant with glutaraldehyde-Single Quaternary ammonium salt disinfectant
The detection of the sterilization effect is carried out according to a test method and a judgment basis of 'technical specification for identifying disinfectant for animals' (2007 edition) by taking escherichia coli 8099, staphylococcus aureus ATCC 6538, pasteurella multocida and hemolytic streptococcus as representatives of common strains.
And (3) detecting the sterilization rate of different disinfectants with the same concentration ratio on escherichia coli, staphylococcus aureus, pasteurella multocida and hemolytic streptococcus, wherein the detection samples are the example 3, the example 4, the comparative example 1 and the comparative example 2 of the invention.
Comparative example 1
Glutaraldehyde-benzalkonium bromide disinfectant; every 100g of the disinfectant contains the following components by weight: 25g of glutaraldehyde, 25g of benzalkonium bromide, 2.5g of fatty alcohol polyoxyethylene, 3.5g of isoamyl acetate and the balance of deionized water.
Comparative example 2
Glutaraldehyde-decamethylammonium bromide disinfectant; every 100g of the disinfectant contains the following components by weight: 25g of glutaraldehyde, 25g of ammonium decamethyl bromide, 2.5g of fatty alcohol polyoxyethylene, 3.5g of isoamyl acetate and the balance of deionized water.
Comparative examples 1 and 2 were prepared as in inventive example 4.
TABLE 1 Sterilization Effect of glutaraldehyde-Compound Quaternary ammonium salt disinfectant and glutaraldehyde-Single Quaternary ammonium salt disinfectant
The results show that the sterilizing effect of the glutaraldehyde-compound quaternary ammonium salt disinfectant on escherichia coli, staphylococcus aureus, pasteurella multocida and hemolytic streptococcus is obviously superior to that of the glutaraldehyde-single quaternary ammonium salt disinfectant, and the killing rate of the glutaraldehyde-compound quaternary ammonium salt disinfectant on four bacteria is over 99.9 percent.
2. Detecting the sterilization rate of the disinfectant containing benzalkonium bromide and decamethylammonium bromide in different weight ratios on escherichia coli, staphylococcus aureus, pasteurella multocida and hemolytic streptococcus:
comparative example 3: 12.5% benzalkonium bromide and 12.5% decamethyl bromide (1: 1);
comparative example 4: 16.67% benzalkonium bromide and 8.33% decamethyl bromide (2: 1);
comparative example 5: 20% benzalkonium bromide and 5% decamethyl bromide (4: 1);
comparative examples 3-5 the other components of the disinfectant product and their weight ratios and methods of preparation were as in example 4.
The action time is 30min, the test is repeated for 10 times to obtain an average value, and the test results of the proportions of the benzalkonium bromide, decamethyl bromide and quaternary ammonium salt are shown in Table 2:
TABLE 2 comparison of the germicidal effectiveness of benzalkonium bromide and benzalkonium bromide combinations at different weight ratios
The above results show that when the concentration ratio of benzalkonium bromide to decamethyl ammonium bromide is 3:1 (as in example 4 of the present invention), the killing rate of the compound quaternary ammonium salt to four bacteria is above 99.9%, which is obviously higher than that of disinfectant products with concentration ratios of 1:1, 2:1 and 4: 1.
Example 6 detection of the Bactericidal Effect of concentrated glutaraldehyde-Compound Quaternary ammonium salt disinfectant
1. The bactericidal effects of the glutaraldehyde and compound quaternary ammonium salt disinfectant with different weight ratios on escherichia coli, staphylococcus aureus, pasteurella multocida, hemolytic streptococcus, pseudomonas aeruginosa, salmonella, bacillus cereus and haemophilus parasuis are detected, and detection samples are as follows:
comparative example 6: 16.7% glutaraldehyde and 33.3% quaternary ammonium complex salt (1: 2);
comparative example 7: 33.3% glutaraldehyde and 16.7% quaternary ammonium complex salt (2: 1);
comparative example 8: 37.5% glutaraldehyde and 12.5% quaternary ammonium complex salt (3: 1);
comparative examples 6-8 the other components of the disinfectant product and their weight ratios and methods of preparation were as in example 4.
TABLE 3 germicidal effectiveness of concentrated glutaraldehyde-compound quaternary ammonium salt disinfectants of different proportions
The results show that under the condition that the concentration ratio is 1:1, when the glutaraldehyde and the compound quaternary ammonium salt are respectively 25% and 25%, the sterilization rate of the concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant to the haemophilus parasuis is 99.89%, the sterilization rate to other 7 bacteria is more than 99.9%, the sterilization rate to the salmonella is 100%, and the concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant has a good antibacterial effect.
Example 7 stability test
1. Preparing concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant containing stabilizer, subpackaging and placing at room temperature for 60-5 days and 60-10 days respectively to perform accelerated stability tests, and detecting the sterilization effect of the disinfectant on pseudomonas aeruginosa, salmonella, bacillus cereus and haemophilus parasuis:
comparative example 9: concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant without adding stabilizer isoamyl acetate
Every 100g of the disinfectant contains the following components by weight: 25g of glutaraldehyde, 6.25g of decamethylammonium bromide, 18.75g of benzalkonium bromide, 2.5g of fatty alcohol polyoxyethylene and the balance of deionized water.
TABLE 4 Sterilization Effect of concentrated glutaraldehyde-Compound Quaternary ammonium salt disinfectant stability
2. Preparing a concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant containing a stabilizer, subpackaging and placing at room temperature, 40-1 month, 40-2 months, 40-3 months and 40-6 months respectively to perform accelerated stability tests, and detecting the sterilization effect of the disinfectant on pseudomonas aeruginosa, salmonella, bacillus cereus and haemophilus parasuis:
TABLE 5 germicidal effectiveness of concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant stability
And (4) experimental conclusion:
the test results show that the disinfectant has no obvious change in bactericidal action when placed at 60 ℃ for 5-10 days, and can still keep good bactericidal action for 6 months at 40 ℃. Compared with the product of the embodiment 4 of the invention, the stability of the glutaraldehyde-compound quaternary ammonium salt disinfectant without stabilizer isoamyl acetate is obviously poorer.
Claims (10)
1. The concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant is characterized by comprising glutaraldehyde and compound quaternary ammonium salt, wherein the compound quaternary ammonium salt consists of decamethyl ammonium bromide and benzalkonium bromide; the concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant comprises the following components in percentage by weight: 10-30% of glutaraldehyde, 5-20% of decamethylammonium bromide, 5-25% of benzalkonium bromide, 0.1-5% of emulsifier, 0.5-8% of stabilizer and the balance of deionized water.
2. The concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant as claimed in claim 1, wherein the concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant comprises the following components in percentage by weight: 15-25% of glutaraldehyde, 5-10% of decamethylammonium bromide, 10-20% of benzalkonium bromide, 1-3% of emulsifier, 1-5% of stabilizer and the balance of deionized water.
3. The concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant as claimed in claim 1 or 2, wherein the weight ratio of decamethyl ammonium bromide to benzalkonium bromide in the compound quaternary ammonium salt is 1: 1-4; the weight ratio of the glutaraldehyde to the compound quaternary ammonium salt is 1: 2-3: 1.
4. The concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant of claim 3, wherein the weight ratio of decamethyl ammonium bromide to benzalkonium bromide in the compound quaternary ammonium salt is 1: 3.
5. The concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant according to claim 3, wherein the weight ratio of glutaraldehyde to compound quaternary ammonium salt is 1: 1.
6. The concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant as claimed in any one of claims 1-5, wherein the concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant comprises the following components in percentage by weight: 25% of glutaraldehyde, 6.25% of decamethylammonium bromide, 18.75% of benzalkonium bromide, 2.5% of emulsifier, 3.5% of stabilizer and the balance of deionized water.
7. The concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant as claimed in claim 1 or 2, wherein the emulsifier is one or more of fatty alcohol polyoxyethylene, lauryl alcohol polyoxyethylene ether and isooctyl polyoxyethylene ether.
8. The concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant of claim 1 or 2, wherein the stabilizer is isoamyl acetate.
9. A preparation method of concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant comprises the following steps:
(1) weighing the raw material components according to the formula amount, dissolving the emulsifier in hot water at 40-70 ℃, stirring until the emulsifier is completely dissolved, and standing to room temperature;
(2) dissolving glutaraldehyde, decamethylammonium bromide and benzalkonium bromide in deionized water, adding the solution obtained in the step (1), and continuously stirring until the solution is dissolved;
(3) and (3) adding a stabilizer into the solution obtained in the step (2), and continuously stirring until the stabilizer is completely dissolved to obtain the composite stabilizer.
10. Use of a concentrated glutaraldehyde-compound quaternary ammonium salt disinfectant according to any one of claims 1 to 9 for disinfection of farms, public places and equipment and apparatus.
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| CN114916544A (en) * | 2022-05-10 | 2022-08-19 | 中国农业科学院饲料研究所 | Compound foam type long-acting disinfectant containing citric acid and preparation method and application thereof |
| CN115039774A (en) * | 2022-06-29 | 2022-09-13 | 苏州艾科尔化工科技有限公司 | Compound disinfectant for controlling banana march disease and panama disease and application thereof |
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| CN101579330A (en) * | 2009-06-25 | 2009-11-18 | 中国农业大学 | Disinfectant for animals and preparation method thereof |
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