CN113519518A - Low-temperature disinfectant - Google Patents
Low-temperature disinfectant Download PDFInfo
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- CN113519518A CN113519518A CN202110670466.2A CN202110670466A CN113519518A CN 113519518 A CN113519518 A CN 113519518A CN 202110670466 A CN202110670466 A CN 202110670466A CN 113519518 A CN113519518 A CN 113519518A
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- low
- temperature
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- ammonium salt
- temperature disinfectant
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 47
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 33
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 31
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims abstract description 12
- CYDRXTMLKJDRQH-UHFFFAOYSA-N benzododecinium Chemical class CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 CYDRXTMLKJDRQH-UHFFFAOYSA-N 0.000 claims abstract description 10
- 238000000034 method Methods 0.000 claims abstract description 6
- 239000002888 zwitterionic surfactant Substances 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims description 6
- 229940073507 cocamidopropyl betaine Drugs 0.000 claims description 6
- JMHWNJGXUIJPKG-UHFFFAOYSA-N CC(=O)O[SiH](CC=C)OC(C)=O Chemical compound CC(=O)O[SiH](CC=C)OC(C)=O JMHWNJGXUIJPKG-UHFFFAOYSA-N 0.000 claims description 4
- RUPBZQFQVRMKDG-UHFFFAOYSA-M Didecyldimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(C)CCCCCCCCCC RUPBZQFQVRMKDG-UHFFFAOYSA-M 0.000 claims description 4
- 229960004670 didecyldimethylammonium chloride Drugs 0.000 claims description 4
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims description 2
- SWLVFNYSXGMGBS-UHFFFAOYSA-N ammonium bromide Chemical compound [NH4+].[Br-] SWLVFNYSXGMGBS-UHFFFAOYSA-N 0.000 claims description 2
- DVEKCXOJTLDBFE-UHFFFAOYSA-N n-dodecyl-n,n-dimethylglycinate Chemical compound CCCCCCCCCCCC[N+](C)(C)CC([O-])=O DVEKCXOJTLDBFE-UHFFFAOYSA-N 0.000 claims description 2
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 16
- 230000000694 effects Effects 0.000 abstract description 15
- 235000011187 glycerol Nutrition 0.000 abstract description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 8
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 6
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 238000002360 preparation method Methods 0.000 abstract description 4
- 238000007710 freezing Methods 0.000 abstract description 3
- 238000011031 large-scale manufacturing process Methods 0.000 abstract description 3
- 239000013543 active substance Substances 0.000 abstract description 2
- 239000012752 auxiliary agent Substances 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 18
- 229920000742 Cotton Polymers 0.000 description 14
- 238000002474 experimental method Methods 0.000 description 12
- 238000005070 sampling Methods 0.000 description 12
- 238000012360 testing method Methods 0.000 description 11
- 230000001954 sterilising effect Effects 0.000 description 8
- 241000588724 Escherichia coli Species 0.000 description 6
- 241000191967 Staphylococcus aureus Species 0.000 description 6
- 239000013641 positive control Substances 0.000 description 6
- 239000001963 growth medium Substances 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 4
- 238000011081 inoculation Methods 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000000249 desinfective effect Effects 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 239000003085 diluting agent Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000003472 neutralizing effect Effects 0.000 description 3
- 239000011550 stock solution Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- KHSLHYAUZSPBIU-UHFFFAOYSA-M benzododecinium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 KHSLHYAUZSPBIU-UHFFFAOYSA-M 0.000 description 2
- JBIROUFYLSSYDX-UHFFFAOYSA-M benzododecinium chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 JBIROUFYLSSYDX-UHFFFAOYSA-M 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000007865 diluting Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- 150000002978 peroxides Chemical class 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- 238000010008 shearing Methods 0.000 description 2
- 238000002791 soaking Methods 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000009736 wetting Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000004880 explosion Methods 0.000 description 1
- 238000005189 flocculation Methods 0.000 description 1
- 230000016615 flocculation Effects 0.000 description 1
- 239000008233 hard water Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 239000000693 micelle Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a low-temperature disinfectant, and belongs to the technical field of disinfection. The components of the low-temperature disinfectant are compounded by adopting two low-temperature auxiliary agents of glycerin and propylene glycol to achieve the anti-freezing effect, so that the product still keeps a flowing state at low temperature; the double-chain quaternary ammonium salt is matched with the dodecyl dimethyl benzyl ammonium salt according to a specific proportion, so that the product has better stability and high surface activity, and meanwhile, the bactericidal capacity of the product can be obviously improved, and the bactericidal broad spectrum is strong. The product does not contain active substances such as ethanol, and has high safety in production, transportation and use processes. The invention also discloses a preparation method of the product, which has simple operation steps and can realize industrialized large-scale production.
Description
Technical Field
The invention relates to the technical field of disinfection, and particularly relates to a low-temperature disinfectant.
Background
Currently, there are many types of conventional commercially available disinfectants, including quaternary ammonium disinfectants, chlorine-containing disinfectants, peroxide disinfectants, and the like. The quaternary ammonium salt disinfectant is non-toxic and odorless, is safe to use and is widely used in the food industry; the peroxide disinfectant is safe due to the decomposition product, and is widely used in the food industry; chlorine-containing disinfectants are often used for disinfecting and sterilizing surfaces of food equipment.
However, the above conventional disinfectants usually solidify at low temperatures, resulting in greatly reduced sterilizing power and failure to achieve sterilizing effect at low temperatures; in addition, low-temperature disinfectants available on the market at present generally contain substances such as ethanol or active salts, and the substances are dangerous in the production, transportation and use processes, and are easy to release heat in a large amount or have the hidden danger of ethanol explosion due to dissolution.
Disclosure of Invention
Based on the defects of the prior art, the invention aims to provide a low-temperature disinfectant, which not only overcomes the defect that the existing product is in a solidification state at low temperature, so that the disinfectant product can give full play to the sterilization effect, but also has stable property and is nonflammable, and can realize safe production, transportation and use.
In order to achieve the purpose, the invention adopts the technical scheme that:
a low-temperature disinfectant comprises the following components in percentage by mass: 10-20% of glycerol, 10-40% of propylene glycol, 0.2-0.5% of double-chain quaternary ammonium salt, 0.01-0.5% of dodecyl dimethyl benzyl ammonium salt and the balance of water.
The low-temperature disinfectant disclosed by the invention is compounded by adopting a proper amount of glycerol and propylene glycol to achieve an anti-freezing effect, so that a product still keeps a flowing state at a low temperature; the double-chain quaternary ammonium salt is matched with the single-chain dodecyl dimethyl benzyl ammonium salt according to a specific proportion, so that the product has better stability and high surface activity, and meanwhile, the bactericidal capability of the product can be obviously improved, and the bactericidal broad spectrum is strong.
Preferably, the double-chain quaternary ammonium salt comprises at least one of didecyl dimethyl ammonium chloride and dioctyl dimethyl ammonium chloride.
The double-chain quaternary ammonium salt has better micelle forming property and stronger capability of reducing surface tension, has high water solubility and strong stability, can effectively kill bacteria and fungi, and has broad spectrum safety.
Preferably, the dodecyl dimethyl benzyl ammonium salt comprises at least one of ammonium chloride salt and ammonium bromide salt.
The dodecyl dimethyl benzyl ammonium salt is a common disinfection component in the prior art, has good cleaning and sterilizing effects, is mild and non-irritant, and has strong compatibility with double-chain quaternary ammonium salt.
Preferably, the low-temperature disinfectant further comprises 0.01-0.5% of a zwitterionic surfactant.
The addition of the surfactant can ensure that the product still keeps good solubility and stability in a treatment environment rich in impurities or hard water, and meanwhile, the substance has a flocculation effect, so that the sterilization and disinfection effects of the product are improved.
More preferably, the zwitterionic surfactant comprises at least one of cocamidopropyl betaine, dodecyl dimethyl betaine.
The invention also aims to provide a preparation method of the low-temperature disinfectant, which comprises the following steps: the low-temperature disinfectant is obtained after all the components are uniformly mixed according to the proportion.
The preparation method of the low-temperature disinfectant has simple operation steps and can realize industrial large-scale production.
The invention has the beneficial effects that: the invention provides a low-temperature disinfectant, which is prepared by compounding two low-temperature auxiliary agents of glycerin and propylene glycol to achieve the anti-freezing effect, so that the product still keeps a flowing state at low temperature; the double-chain quaternary ammonium salt is matched with the single-chain dodecyl dimethyl benzyl ammonium salt according to a specific content, so that the product has better stability and high surface activity, and meanwhile, the bactericidal capability of the product can be obviously improved, and the bactericidal broad spectrum is strong. The product does not contain active substances such as ethanol, and has high safety in production, transportation and use processes. The invention also provides a preparation method of the product, which has simple operation steps and can realize industrialized large-scale production.
Detailed Description
For better illustrating the objects, technical solutions and advantages of the present invention, the present invention will be further described with reference to specific examples, which are intended to be understood in detail, but not intended to limit the present invention.
Example 1
The low-temperature disinfectant comprises the following components in percentage by mass: 15% of glycerol, 25% of propylene glycol, 0.4% of didecyl dimethyl ammonium chloride, 0.2% of dodecyl dimethyl benzyl ammonium chloride, 0.3% of zwitterionic surfactant and the balance of water; the zwitterionic surfactant is cocamidopropyl betaine.
Example 2
The low-temperature disinfectant comprises the following components in percentage by mass: 16% of glycerol, 20% of propylene glycol, 0.2% of dioctyl dimethyl ammonium chloride, 0.2% of dodecyl dimethyl benzyl ammonium bromide, 0.3% of zwitterionic surfactant and the balance of water; the zwitterionic surfactant is cocamidopropyl betaine.
Example 3
The low-temperature disinfectant comprises the following components in percentage by mass: 10% of glycerol, 40% of propylene glycol, 0.5% of dioctyl dimethyl ammonium chloride, 0.5% of dodecyl dimethyl benzyl ammonium bromide, 0.05% of zwitterionic surfactant and the balance of water; the zwitterionic surfactant is cocamidopropyl betaine.
Comparative example 1
The comparative example differs from example 1 only in that the product of the comparative example contains no glycerol in its components.
Comparative example 2
The comparative example differs from example 1 only in that the product described in the comparative example does not contain propylene glycol in its components.
Comparative example 3
The comparative example differs from example 1 only in that the product of the comparative example does not contain a double-stranded quaternary ammonium salt in its composition.
Comparative example 4
The comparative example differs from example 1 only in that the product of the comparative example does not contain dodecyldimethylbenzylammonium salt in its composition.
Comparative example 5
The low-temperature disinfectant comprises the following components in percentage by mass: 15% of glycerol, 25% of propylene glycol, 0.1% of didecyl dimethyl ammonium chloride, 0.6% of dodecyl dimethyl benzyl ammonium chloride, 0.3% of zwitterionic surfactant and the balance of water; the zwitterionic surfactant is cocamidopropyl betaine.
Effect example 1
In order to verify the low-temperature stability of the low-temperature disinfectant, 5mL of the products of the example 1, the comparative example 1 and the comparative example 2 are respectively placed in a low-temperature storage box of QSP-B-F004 model, stored overnight (more than 8h) under the conditions of-20 ℃ and 66% humidity, and observed according to the disinfection technical specification (2002 edition) -2.2.3.1 of Ministry of health).
The experimental results are as follows: the product of the example 1 keeps a liquid state after being tested, and has no precipitation and crystallization phenomena; the products of comparative examples 2 and 3 were partially precipitated and could not be maintained in a liquid state.
Experiments show that the product of the invention can still keep the original liquid state at low temperature and has high stability.
Effect example 2
In order to verify the sterilization effect of the low-temperature disinfectant, the low-temperature carrier killing experiment is carried out on the products obtained in the example 1 and the comparative examples 3-5:
(1) experiment article
Experimental strains: escherichia coli 8099, staphylococcus aureus ATCC 6538;
neutralizing agent: D/E neutralization broth;
carrier: a glass sheet;
a cryostat (DH 30-30-V);
and others: PBS containing 0.1% Tween 80, sterile cotton swab, etc.
(2) Experimental methods
The detection basis is as follows: specification for Disinfection (Ministry of health 2002) 2.1.2.9; notice of the national institutes of health and wellness on the technical requirements of the evaluation of the hygiene and safety of low-temperature disinfectants;
culture temperature and time: at 37 ℃ for 48 h;
detecting the environment: 21 ℃ and 54% relative humidity.
(3) Procedure of experiment
(a) The experiment is carried out in a low-temperature constant-temperature groove at the temperature of 20 ℃ below zero, a carrier is provided with a contamination (escherichia coli or staphylococcus aureus) area which is divided into an experiment group area and a positive control group area with the same area, a sterile cotton swab is used for being dipped with the bacterial suspension and evenly smeared on the areas, and the areas are placed in the low-temperature constant-temperature groove at the temperature of 20 ℃ below zero for 30min for later use;
(b) experimental groups: after the temperature of the carrier reaches-20 ℃, spraying and disinfecting the carrier for 15min, 30min and 45min by using the sample stock solution, soaking a sterile cotton swab and a test tube containing 10mL of neutralizer after acting for corresponding time, smearing and sampling different blocks respectively, and enabling each block to reciprocate horizontally and vertically for 8 times. After sampling, the sampling end of the cotton swab is cut into the original neutralizer test tube in an aseptic operation mode, the cotton swab is properly diluted after full vibration, and 1mL of inoculation culture medium is sucked for culture;
(c) positive control group: wiping sterile cotton in a test tube containing 10mL of diluent for wetting, smearing and sampling control blocks, wherein each block reciprocates transversely and vertically for 8 times respectively, shearing a sampling end of the cotton swab into an original neutralizer test tube in a sterile operation mode after sampling, adequately shaking and then diluting properly, and sucking 1mL of inoculation culture medium for culturing;
(d) after repeating the above experimental group three times, each killing log value is counted, and the test results are shown in table 1 and table 2.
TABLE 1
TABLE 2
As can be seen from tables 1 and 2, compared with the comparative example, the low-temperature disinfectant stock solution obtained by the invention has obvious sterilization effect on Escherichia coli and Staphylococcus aureus in the low-temperature environment of-20 ℃, and the killing logarithm value is more than 5 at different times, thereby meeting the sanitary requirements of the technical Specification for disinfection (2002 edition of Ministry of health and health Commission) and the Notification of the technical requirement on the sanitary safety evaluation of low-temperature disinfectant for printing and sending in the national health Commission office.
Effect example 3
To verify the actual disinfection effect of the low-temperature disinfectant product obtained by the invention, the product of example 1 was subjected to a field simulation experiment:
(1) experiment article
Experimental strains: escherichia coli 8099, staphylococcus aureus ATCC 6538;
neutralizing agent: D/E neutralization broth;
carrier: a glass sheet;
a cryostat (DH 30-30-V);
and others: PBS containing 0.1% Tween 80, sterile cotton swab, and sterilization standard plate.
(2) Experimental methods
The detection basis is as follows: specification for Disinfection (Ministry of health 2002) 2.1.2.9; notice of the national institutes of health and wellness on the technical requirements of the evaluation of the hygiene and safety of low-temperature disinfectants;
culture temperature and time: at 37 ℃ for 48 h;
detecting the environment: 21 ℃ and 54% relative humidity.
(3) Procedure of experiment
(a) The experiment was carried out in a cryostat at-20 ℃ and the stained area (5X 5 cm) was marked on the support using a sterile format plate2) The staining area (Escherichia coli or Staphylococcus aureus) is divided into 60 blocks, sterile cotton is used for dipping and uniformly smearing bacterial suspension on the blocks, the blocks are divided into 30 experimental group blocks and 30 positive control group blocks, and the experimental group blocks and the positive control group blocks are placed in a low-temperature constant-temperature bath at the temperature of-20 ℃ for 30min for later use;
(b) experimental groups: after the temperature of the carrier reaches-20 ℃, spraying and disinfecting the carrier by using the sample stock solution for 30min, soaking a sterile cotton swab in a test tube containing 10mL of neutralizer after the carrier is acted for 30min, smearing and sampling 30 disinfection blocks respectively, and enabling each block to reciprocate horizontally and vertically for 8 times. After sampling, the sampling end of the cotton swab is cut into the original neutralizer test tube in an aseptic operation mode, the cotton swab is properly diluted after full vibration, and 1mL of inoculation culture medium is sucked for culture;
(c) positive control group: wiping sterile cotton in a test tube containing 10mL of diluent for wetting, smearing and sampling 30 control blocks, wherein each block moves back and forth 8 times in a transverse and vertical mode, shearing a sampling end of the cotton swab into an original neutralizer test tube in a sterile operation mode after sampling, adequately shaking, diluting properly, and sucking 1mL of inoculation culture medium for culturing;
(d) negative control group: after the experiment of the experimental group and the positive control group is finished, 1mL of each unused neutralizing agent and diluent in the same batch is inoculated into a culture medium for culture.
The colony counts and the killing log values of each group were counted, and the test results are shown in tables 3 and 4.
TABLE 3
TABLE 4
Test results of 30 detection samples show that the low-temperature disinfectant can disinfect carriers containing escherichia coli and staphylococcus aureus in practical application at the low temperature of-20 ℃, the killing log values are respectively more than 3, and the disinfection degree is qualified, so that the low-temperature disinfectant meets the sanitary requirements of disinfection technical specifications (2002 edition of Ministry of health) and notice of technical requirements of national health Commission office on the sanitary safety evaluation of low-temperature disinfectant.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (7)
1. The low-temperature disinfectant is characterized by comprising the following components in percentage by mass: 10-20% of glycerol, 10-40% of propylene glycol, 0.2-0.5% of double-chain quaternary ammonium salt, 0.01-0.5% of dodecyl dimethyl benzyl ammonium salt and the balance of water.
2. A low temperature disinfectant according to claim 1, wherein said double chain quaternary ammonium salt comprises at least one of didecyldimethylammonium chloride and dioctyldimethylammonium chloride.
3. A low temperature disinfectant according to claim 1, wherein said dodecyldimethylbenzyl ammonium salt comprises at least one of an ammonium chloride salt and an ammonium bromide salt.
4. A low temperature disinfectant according to claim 1, wherein said low temperature disinfectant further comprises 0.01-0.5% of a zwitterionic surfactant.
5. A low temperature disinfectant according to claim 4, wherein said zwitterionic surfactant comprises at least one of cocamidopropyl betaine and dodecyl dimethyl betaine.
6. The low-temperature disinfectant as claimed in claim 5, wherein the low-temperature disinfectant comprises the following components in percentage by mass: 15% of glycerol, 25% of propylene glycol, 0.4% of double-chain quaternary ammonium salt, 0.2% of dodecyl dimethyl benzyl ammonium salt, 0.3% of zwitterionic surfactant and the balance of water.
7. A method of preparing a low temperature disinfectant as claimed in any of claims 1 to 6, comprising the steps of: the low-temperature disinfectant is obtained after all the components are uniformly mixed according to the proportion.
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| CN202110670466.2A CN113519518A (en) | 2021-06-16 | 2021-06-16 | Low-temperature disinfectant |
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| CN202110670466.2A CN113519518A (en) | 2021-06-16 | 2021-06-16 | Low-temperature disinfectant |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114403143A (en) * | 2022-01-21 | 2022-04-29 | 广州蓝月亮实业有限公司 | Anti-freezing quaternary ammonium salt composition and preparation method and application thereof |
| CN115606592A (en) * | 2022-10-31 | 2023-01-17 | 大连理工大学 | Low-temperature quaternary ammonium salt disinfectant and application thereof |
| CN116114715A (en) * | 2022-12-29 | 2023-05-16 | 江苏康巴特生物工程有限公司 | Low-temperature quaternary ammonium salt disinfectant for livestock and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112741087A (en) * | 2021-01-05 | 2021-05-04 | 北京洛娃日化有限公司 | Cold chain food disinfectant and preparation method thereof |
-
2021
- 2021-06-16 CN CN202110670466.2A patent/CN113519518A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112741087A (en) * | 2021-01-05 | 2021-05-04 | 北京洛娃日化有限公司 | Cold chain food disinfectant and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114403143A (en) * | 2022-01-21 | 2022-04-29 | 广州蓝月亮实业有限公司 | Anti-freezing quaternary ammonium salt composition and preparation method and application thereof |
| CN115606592A (en) * | 2022-10-31 | 2023-01-17 | 大连理工大学 | Low-temperature quaternary ammonium salt disinfectant and application thereof |
| CN116114715A (en) * | 2022-12-29 | 2023-05-16 | 江苏康巴特生物工程有限公司 | Low-temperature quaternary ammonium salt disinfectant for livestock and preparation method thereof |
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Application publication date: 20211022 |