CN113940357A - Polyhexamethylene guanidine silver ion composite disinfectant - Google Patents
Polyhexamethylene guanidine silver ion composite disinfectant Download PDFInfo
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- CN113940357A CN113940357A CN202110026067.2A CN202110026067A CN113940357A CN 113940357 A CN113940357 A CN 113940357A CN 202110026067 A CN202110026067 A CN 202110026067A CN 113940357 A CN113940357 A CN 113940357A
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- Prior art keywords
- polyhexamethylene guanidine
- silver
- silver ion
- ion composite
- composite disinfectant
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- -1 Polyhexamethylene guanidine silver Polymers 0.000 title claims abstract description 82
- 239000000645 desinfectant Substances 0.000 title claims abstract description 79
- 239000002131 composite material Substances 0.000 title claims abstract description 57
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 title claims abstract description 53
- 238000002845 discoloration Methods 0.000 claims abstract description 28
- GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229910052709 silver Inorganic materials 0.000 claims abstract description 12
- 239000004332 silver Substances 0.000 claims abstract description 12
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 claims description 22
- 229910001961 silver nitrate Inorganic materials 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 239000000243 solution Substances 0.000 claims description 8
- 241000588724 Escherichia coli Species 0.000 claims description 7
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims description 7
- 241000191967 Staphylococcus aureus Species 0.000 claims description 7
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 7
- 239000007864 aqueous solution Substances 0.000 claims description 7
- 239000012266 salt solution Substances 0.000 claims description 6
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 4
- 229920002873 Polyethylenimine Polymers 0.000 claims description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 4
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 claims description 3
- NAPSCFZYZVSQHF-UHFFFAOYSA-N dimantine Chemical compound CCCCCCCCCCCCCCCCCCN(C)C NAPSCFZYZVSQHF-UHFFFAOYSA-N 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- ZXSQEZNORDWBGZ-UHFFFAOYSA-N 1,3-dihydropyrrolo[2,3-b]pyridin-2-one Chemical compound C1=CN=C2NC(=O)CC2=C1 ZXSQEZNORDWBGZ-UHFFFAOYSA-N 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- CQLFBEKRDQMJLZ-UHFFFAOYSA-M silver acetate Chemical compound [Ag+].CC([O-])=O CQLFBEKRDQMJLZ-UHFFFAOYSA-M 0.000 claims description 2
- 229940071536 silver acetate Drugs 0.000 claims description 2
- LKZMBDSASOBTPN-UHFFFAOYSA-L silver carbonate Substances [Ag].[O-]C([O-])=O LKZMBDSASOBTPN-UHFFFAOYSA-L 0.000 claims description 2
- 229910001958 silver carbonate Inorganic materials 0.000 claims description 2
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 claims description 2
- 229940043237 diethanolamine Drugs 0.000 claims 1
- 230000001954 sterilising effect Effects 0.000 abstract description 9
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 description 14
- 239000004744 fabric Substances 0.000 description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- 230000008859 change Effects 0.000 description 6
- 230000000844 anti-bacterial effect Effects 0.000 description 5
- 230000003385 bacteriostatic effect Effects 0.000 description 5
- 239000002244 precipitate Substances 0.000 description 5
- 239000011780 sodium chloride Substances 0.000 description 4
- 238000005494 tarnishing Methods 0.000 description 4
- 229920001661 Chitosan Polymers 0.000 description 3
- 229920002413 Polyhexanide Polymers 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 2
- 210000004666 bacterial spore Anatomy 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 239000011259 mixed solution Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- NDVLTYZPCACLMA-UHFFFAOYSA-N silver oxide Chemical compound [O-2].[Ag+].[Ag+] NDVLTYZPCACLMA-UHFFFAOYSA-N 0.000 description 2
- 239000008399 tap water Substances 0.000 description 2
- 235000020679 tap water Nutrition 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 150000001767 cationic compounds Chemical class 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000012286 potassium permanganate Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 229910001923 silver oxide Inorganic materials 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
Abstract
The invention relates to a polyhexamethylene guanidine silver ion composite disinfectant, which comprises water-soluble silver salt, polyhexamethylene guanidine hydrochloride and an anti-discoloration factor, wherein the concentration of the water-soluble silver salt is 5 mg/L-50 mg/L, the concentration of the polyhexamethylene guanidine hydrochloride is 0.5 g/L-5 g/L, the concentration of the anti-discoloration factor is 100 mg/L-500 mg/L, and the anti-discoloration factor comprises a water-soluble amine compound. The polyhexamethylene guanidine silver ion composite disinfectant disclosed by the invention has the advantages that the concentration of silver ions is reduced, meanwhile, the excellent sterilization effect can be achieved, and the polyhexamethylene guanidine silver ion composite disinfectant has better discoloration resistance, including no discoloration at high temperature, no discoloration under sunlight exposure, chlorine resistance and the like.
Description
Technical Field
The invention relates to the field of silver ion disinfectants, in particular to a polyhexamethylene guanidine silver ion composite disinfectant.
Background
The most widely used chemical disinfectants at present mainly comprise: alcohol, hydrogen peroxide, potassium permanganate, aldehydes and the like, and the disinfectants have high irritation and oxidability and are easy to cause permanent damage to the skin. Meanwhile, most of the disinfection products on the market have flammability or combustion-supporting property, which puts higher requirements on production, transportation and use environments.
The polyhexamethylene guanidine is an environment-friendly high-molecular polymer, is a broad-spectrum bactericide with the widest application, has the characteristics of high action speed, long bacteriostatic aging, weak corrosivity, stable performance and the like, and is safe to use. But when the disinfectant is used singly, bacterial spores and bacterial spores cannot be killed, so the disinfectant belongs to a low-efficiency disinfectant.
The silver ion solution is colorless, tasteless and nonirritant, belongs to a pollution-free green sterilization product, and is widely applied to plastics, ceramics, living goods, sanitary goods and textiles. When used singly, the disinfectant can kill mycobacteria, fungi, viruses and bacterial propagules at higher concentration, and belongs to a middle-effect disinfectant; but have limited bactericidal capacity at low concentrations. When used at high concentration, the product has high cost and can cause irritation to human skin mucosa.
Many silver ion composite disinfectants on the market at present have many problems: 1. the disinfectant is not resistant to chloride ions, and when the disinfectant is diluted and mixed with tap water, the chloride ions in the tap water can react with silver ions to generate white precipitates, so that the using effect of the disinfectant is influenced. 2. The product is not resistant to high temperature and sunlight, and the silver ion disinfectant can be gradually decomposed after long-time high-temperature solarization storage in the transportation and use processes, so that the appearance and the performance of the product are influenced. 3. After the silver ion disinfectant is sprayed and dried, Ag + remained on the surface of the object is gradually oxidized into silver oxide and becomes black, so that the appearance is influenced.
CN100435642C discloses a chitosan-based composite antibacterial agent, which is prepared from silver salt, chitosan and a cationic compound to obtain an anti-discoloration chitosan complex silver antibacterial agent. CN 109380298A discloses a colorless transparent anti-discoloration nano-silver composite antibacterial agent solution, which adopts polyethyleneimine as an anti-discoloration factor. More types of anti-tarnish silver ion composite disinfectants are developed, and it is necessary to reduce the concentration of silver ions in the disinfectants.
Disclosure of Invention
In order to solve the technical problems, the invention aims to provide a polyhexamethylene guanidine silver ion composite disinfectant, which has the advantages of reducing the concentration of silver ions, achieving excellent sterilization effect and better discoloration resistance.
In order to achieve the purpose, the invention adopts the following technical scheme:
a polyhexamethylene guanidine silver ion composite disinfectant comprises water-soluble silver salt, polyhexamethylene guanidine hydrochloride and an anti-discoloration factor, wherein,
in the composite disinfectant, the concentration of the water-soluble silver salt is 5 mg/L-50 mg/L, the concentration of the polyhexamethylene guanidine hydrochloride is 0.5 g/L-5 g/L, the concentration of the discoloration-resistant factor is 100 mg/L-500 mg/L, and the discoloration-resistant factor comprises a water-soluble amine compound.
Further, the water-soluble amine compound comprises one or more of polyethyleneimine, octadecyl dimethyl ammonium oxide, percarbamide and cocoyl diethanolamine.
Further, the water-soluble silver salt comprises one or more of silver nitrate, silver acetate and silver carbonate.
Further, the pH value of the polyhexamethylene guanidine silver ion composite disinfectant is 6-8.
Further, one or more of triethanolamine, ethanolamine, fatty acyl diamine, hydrochloric acid and sulfuric acid is used for adjusting the pH value of the disinfectant.
Further, the concentration of the water-soluble silver salt was 5mg/L, the concentration of polyhexamethylene biguanide hydrochloride was 0.5g/L, and the concentration of the discoloration inhibitor was 100 mg/L.
Further, the preparation method of the polyhexamethylene guanidine silver ion composite disinfectant comprises the following steps:
(1) uniformly mixing the water solution of the water-soluble silver salt and the anti-discoloration factor to complex silver ions and the anti-discoloration factor to obtain a silver salt solution;
(2) and (2) uniformly mixing the polyhexamethylene guanidine hydrochloride powder or the aqueous solution, the silver salt solution obtained in the step (1) and water to obtain the polyhexamethylene guanidine silver ion composite disinfectant.
Further, in the step (2), the step of adjusting the pH of the solution to 6-8 is included after the uniform mixing.
Further, the polyhexamethylene guanidine silver ion composite disinfectant is used for resisting one or more of escherichia coli, pseudomonas aeruginosa and staphylococcus aureus.
Further, the minimum inhibitory concentration of the polyhexamethylene guanidine silver ion composite disinfectant is 0.5 g/L.
By the scheme, the invention at least has the following advantages:
1. the polyhexamethylene guanidine silver ion composite disinfectant disclosed by the invention contains silver ions and polyhexamethylene guanidine, so that the concentration of the silver ions is reduced, an excellent sterilization effect can be achieved, and the sterilization rate of the polyhexamethylene guanidine silver ion composite disinfectant on escherichia coli, pseudomonas aeruginosa and staphylococcus aureus can reach more than 99.99%.
2. The polyhexamethylene guanidine silver ion composite disinfectant contains the anti-tarnishing factor which can form a stable complex with silver ions to prevent the silver ions from being oxidized. Therefore, the composite disinfectant of the invention can not change color after being continuously exposed for one month in the sun, can not change color after being baked for 120 hours at the high temperature of 80 ℃, can not generate white precipitate after being mixed with sodium chloride aqueous solution, and can not change color after being sprayed on white fabrics and naturally dried.
The foregoing is a summary of the present invention, and in order to provide a clear understanding of the technical means of the present invention and to be implemented in accordance with the present specification, the following is a preferred embodiment of the present invention and is described in detail below.
Detailed Description
The following examples are given to further illustrate the embodiments of the present invention. The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention.
Example 1
The polyhexamethylene guanidine silver ion composite disinfectant comprises the following components:
silver nitrate, polyhexamethylene guanidine hydrochloride, an anti-tarnishing factor, namely octadecyl dimethyl ammonium oxide and water. Wherein the concentration of silver nitrate is 50mg/L, the concentration of polyhexamethylene guanidine hydrochloride is 5g/L, the concentration of an anti-discoloration factor is 500mg/L, 5mL of triethanolamine is obtained, and the pH value of the disinfectant is 6-8.
The preparation method of the polyhexamethylene guanidine silver ion composite disinfectant comprises the following steps:
(1) mixing and stirring the silver nitrate aqueous solution and the anti-discoloration factor to fully complex silver ions and the anti-discoloration factor to obtain a silver salt solution;
(2) compounding and uniformly mixing polyhexamethylene guanidine hydrochloride powder, the silver salt solution obtained in the step (1) and water to obtain a mixed solution;
(3) and (3) adding triethanolamine into the mixed solution obtained in the step (2), and adjusting the pH value of the solution to maintain the pH value of the solution at 6-8.
The antibacterial property and the discoloration resistance of the polyhexamethylene guanidine silver ion composite disinfectant are tested, and the results are as follows:
after 10min, the sterilizing rate of the disinfectant on escherichia coli, pseudomonas aeruginosa and staphylococcus aureus is over 99.99 percent, and the bacteriostatic concentration of the polyhexamethylene guanidine silver ion composite disinfectant is 5 g/L. The color of the product is not changed after the product is continuously exposed for one month under the sun, and the product is not changed after being baked for 120 hours at the high temperature of 80 ℃. 50mL of the composite disinfectant does not generate white precipitate after being mixed with a sodium chloride aqueous solution (the concentration is 20 g/L). The polyhexamethylene guanidine silver ion composite disinfectant is sprayed on a white fabric for natural airing, and the fabric cannot change color after 24 hours.
Example 2
The embodiment provides a polyhexamethylene guanidine silver ion composite disinfectant, which comprises the following components:
silver nitrate, polyhexamethylene biguanide hydrochloride, an anti-discoloration factor-cocoyl diethanolamine and water. Wherein the concentration of silver nitrate is 25mg/L, the concentration of polyhexamethylene guanidine hydrochloride is 2.5g/L, the concentration of an anti-tarnishing factor is 200mg/L, the concentration of triethanolamine is 2mL, and the pH value of the disinfectant is 6-8.
The procedure for preparing the above polyhexamethylene guanidine silver ion composite disinfectant is the same as that of example 1.
The antibacterial property and the discoloration resistance of the polyhexamethylene guanidine silver ion composite disinfectant are tested, and the results are as follows:
after 10min, the sterilizing rate of the disinfectant on escherichia coli, pseudomonas aeruginosa and staphylococcus aureus is over 99.99 percent, and the bacteriostatic concentration of the polyhexamethylene guanidine silver ion composite disinfectant is 2.5 g/L. The color of the product is not changed after the product is continuously exposed for one month under the sun, and the product is not changed after being baked for 120 hours at the high temperature of 80 ℃. 50mL of the composite disinfectant does not generate white precipitate after being mixed with a sodium chloride aqueous solution (the concentration is 20 g/L). The polyhexamethylene guanidine silver ion composite disinfectant is sprayed on a white fabric for natural airing, and the fabric cannot change color after 24 hours.
Example 3
The embodiment provides a polyhexamethylene guanidine silver ion composite disinfectant, which comprises the following components:
silver nitrate, polyhexamethylene guanidine hydrochloride, antithromic factor-polyethyleneimine and water. Wherein the concentration of silver nitrate is 5mg/L, the concentration of polyhexamethylene guanidine hydrochloride is 0.5g/L, the concentration of an anti-tarnishing factor is 100mg/L, 0.5mL of triethanolamine and the pH value of the disinfectant is 6-8.
The procedure for preparing the above polyhexamethylene guanidine silver ion composite disinfectant is the same as that of example 1.
The antibacterial property and the discoloration resistance of the polyhexamethylene guanidine silver ion composite disinfectant are tested, and the results are as follows:
after 10min, the sterilizing rate of the disinfectant on escherichia coli, pseudomonas aeruginosa and staphylococcus aureus is over 99.99 percent, and the bacteriostatic concentration of the polyhexamethylene guanidine silver ion composite disinfectant is 0.5 g/L. The color of the product is not changed after the product is continuously exposed for one month under the sun, and the product is not changed after being baked for 120 hours at the high temperature of 80 ℃. 50mL of the composite disinfectant does not generate white precipitate after being mixed with a sodium chloride aqueous solution (the concentration is 20 g/L). The polyhexamethylene guanidine silver ion composite disinfectant is sprayed on a white fabric for natural airing, and the fabric cannot change color after 24 hours.
Comparative example 1
A silver ion composite disinfectant comprises the following components:
silver nitrate, polyhexamethylene biguanide hydrochloride and water. Wherein the concentration of silver nitrate is 5mg/L, the concentration of polyhexamethylene guanidine hydrochloride is 1g/L, 0.5mL of triethanolamine is obtained, and the pH value of the disinfectant is 6-8.
The sterilization rate of the disinfectant on escherichia coli, pseudomonas aeruginosa and staphylococcus aureus is 99%, and the bacteriostatic concentration is 1 g/L. The polyhexamethylene guanidine silver ion composite disinfectant is sprayed on a white fabric to be naturally dried, and the fabric is discolored within 10 min.
The above is only a preferred embodiment of the present invention, and is not intended to limit the present invention, it should be noted that, for those skilled in the art, many modifications and variations can be made without departing from the technical principle of the present invention, and these modifications and variations should also be regarded as the protection scope of the present invention.
Claims (10)
1. The polyhexamethylene guanidine silver ion composite disinfectant is characterized in that: comprises water-soluble silver salt, polyhexamethylene guanidine hydrochloride and an anti-tarnish factor, wherein,
in the composite disinfectant, the concentration of the water-soluble silver salt is 5-50 mg/L, the concentration of the polyhexamethylene guanidine hydrochloride is 0.5-5 g/L, the concentration of the discoloration-resistant factor is 100-500 mg/L, and the discoloration-resistant factor comprises a water-soluble amine compound.
2. The polyhexamethylene guanidine silver ion composite disinfectant as set forth in claim 1, wherein: the water-soluble amine compound comprises one or more of polyethyleneimine, octadecyl dimethyl ammonium oxide, percarbamide and cocoyl diethanol amine.
3. The polyhexamethylene guanidine silver ion composite disinfectant as set forth in claim 1, wherein: the water-soluble silver salt comprises one or more of silver nitrate, silver acetate and silver carbonate.
4. The polyhexamethylene guanidine silver ion composite disinfectant as set forth in claim 1, wherein: the pH value of the polyhexamethylene guanidine silver ion composite disinfectant is 6-8.
5. The polyhexamethylene guanidine silver ion composite disinfectant as set forth in claim 4, wherein: one or more of triethanolamine, ethanolamine, fatty acyl diamine, hydrochloric acid and sulfuric acid is used for adjusting the pH value of the disinfectant.
6. The polyhexamethylene guanidine silver ion composite disinfectant as set forth in claim 1, wherein: the concentration of the water-soluble silver salt is 5mg/L, the concentration of the polyhexamethylene guanidine hydrochloride is 0.5g/L, and the concentration of the discoloration-resistant factor is 100 mg/L.
7. The polyhexamethylene guanidine silver ion composite disinfectant according to any one of claims 1 to 6, characterized in that the preparation method comprises the following steps:
(1) uniformly mixing the water solution of the water-soluble silver salt and the anti-discoloration factor to complex the silver ions and the anti-discoloration factor to obtain a silver salt solution;
(2) and (2) uniformly mixing polyhexamethylene guanidine hydrochloride powder or an aqueous solution, the silver salt solution obtained in the step (1) and water to obtain the polyhexamethylene guanidine silver ion composite disinfectant.
8. The polyhexamethylene guanidine silver ion composite disinfectant as set forth in claim 7, wherein: in the step (2), the step of adjusting the pH of the solution to 6-8 is further included after the uniform mixing.
9. The polyhexamethylene guanidine silver ion composite disinfectant as set forth in claim 1, wherein: the polyhexamethylene guanidine silver ion composite disinfectant is used for resisting one or more of escherichia coli, pseudomonas aeruginosa and staphylococcus aureus.
10. The polyhexamethylene guanidine silver ion composite disinfectant as set forth in claim 9, wherein: the minimum inhibitory concentration of the polyhexamethylene guanidine silver ion composite disinfectant is 0.5 g/L.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111281879A (en) * | 2020-03-18 | 2020-06-16 | 成都斯瑞宁科技有限公司 | Wound disinfectant |
| CN116019126A (en) * | 2022-12-09 | 2023-04-28 | 点金新型材料研究院(厦门)有限公司 | Composite antibacterial agent and preparation method thereof |
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| CN1934952A (en) * | 2006-10-14 | 2007-03-28 | 青岛大学 | Method for preparing anti-tarnish chitosan complex silver antibacterial agent |
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| CN116019126A (en) * | 2022-12-09 | 2023-04-28 | 点金新型材料研究院(厦门)有限公司 | Composite antibacterial agent and preparation method thereof |
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