CN111226998A

CN111226998A - Wet tissue for wiping object surface

Info

Publication number: CN111226998A
Application number: CN202010162954.8A
Authority: CN
Inventors: 刘达治
Original assignee: Hedun Chemical Shanghai Co Ltd
Current assignee: Hedun Chemical Shanghai Co Ltd
Priority date: 2020-03-10
Filing date: 2020-03-10
Publication date: 2020-06-05

Abstract

The invention belongs to the technical field of medical bacteriostatic agents, and particularly relates to a wet tissue for wiping an object surface. The bacteriostatic composition for the wet tissue comprises the following components in percentage by weight: 15-25% of organosilicon quaternary ammonium salt, 3-8% of polyhexamethylene guanidine hydrochloride, 0.1-0.5% of ginger extract, 0.01-1% of aloe extract, 0.5-5% of surfactant and the balance of water. The organosilicon quaternary ammonium salt has excellent antibacterial effect, and has synergistic effect with the ginger extract and the aloe extract, so that the product has broad-spectrum antibacterial property; in the invention, the organosilicon quaternary ammonium salt and the nano-silver are used as main antibacterial components and are compounded with the surfactant in a certain proportion, so that the antibacterial activity and the decontamination performance of the product are enhanced.

Description

Wet tissue for wiping object surface

Technical Field

The invention belongs to the technical field of medical disinfectants, and particularly relates to a wet tissue for wiping an object surface.

Background

In recent years, people are becoming more aware of the hazards of "multiple pathogens". "multiple pathogens" represent a major challenge in the public health field. The world health organization has proposed a series of pathogenic bacteria to facilitate research and development in the field of antibiotics. The excessive and inappropriate use of antibiotics is the main cause of bacterial resistance. Nowadays, 890 multiple pathogens have been found, the number of which far exceeds the number of antibiotics used to combat them. This is mainly because the rate of resistance development by bacteria is much higher than the rate of development of new and effective drugs. Although selective use of antibiotics can solve this problem to some extent, prevention of bacterial infection is the most effective way. Once a single bacterium has propagated to form a biofilm, the extracellular matrix can instead play a protective role, which is beyond the normal immune range of the human body, and it is difficult for antibiotics to inhibit its growth. Studies have shown that antibiotics in excess of 1000 times the normal dose kill bacteria entrapped within the biofilm. Therefore, the antibacterial material has a good application prospect in the fields of public health, medical treatment, food packaging and the like, can effectively prevent bacteria from adhering and breeding, and reduces harm to human health.

Wet wipes are essential fast-moving products for modern people, and are almost involved every day. With the reduction of the resistance of infants and children, the microbial safety of the external environment becomes a great threat to the physical health of infants and children, and therefore, the consumption demands of the anti-bacteria wet tissue are increasing. The common non-woven fabrics are generally adopted in the anti-bacterial and bacteriostatic wet tissues on the market, the common non-woven fabrics generally adopt viscose components with formaldehyde slow release, and formaldehyde is easy to detect. Secondly, in order to achieve the anti-corrosion effect, a preservative is generally added into the wet tissue solution. Thirdly, in order to achieve the anti-bacterial and bacteriostatic effects, bacteriostatic components capable of causing the denaturation of microbial proteins or destroying the reverse permeability of cell membranes are added into the wet tissue liquid. The obtained anti-bacteria and bacteriostatic wet tissue is easy to consume anti-bacteria and bacteriostatic components, has difficult maintenance of performance, is allergic due to addition of more bacteriostatic agents or preservatives, and can cause drug resistance of microorganisms.

Disclosure of Invention

In order to solve the above problems, the first aspect of the present invention provides a bacteriostatic composition for wet tissues, which comprises the following components, by weight: 15-25% of organosilicon quaternary ammonium salt, 3-8% of polyhexamethylene guanidine hydrochloride, 0.1-0.5% of ginger extract, 0.01-1% of aloe extract, 0.5-5% of surfactant and the balance of water.

As a preferred technical scheme, the paint comprises the following components in percentage by weight: 18-22% of organosilicon quaternary ammonium salt, 4-7% of polyhexamethylene guanidine hydrochloride, 0.2-0.4% of ginger extract, 0.05-1% of aloe extract, 0.5-2% of surfactant and the balance of water.

As a preferable technical scheme, the bacteriostatic composition further comprises nano silver.

As a preferable technical scheme, the concentration of the nano silver in the bacteriostatic composition is 500-5000 ppm.

As a preferable technical scheme, the average grain diameter of the nano silver is 1-10 nm.

As a preferable technical scheme, the organosilicon quaternary ammonium salt is dimethyl alkyl [3- (trimethoxysilyl) propyl ] ammonium halide containing C18-C30 carbon chains.

In a second aspect, the invention provides a wet tissue for wiping a surface of a body, which comprises a wet tissue carrier and the antibacterial composition.

As a preferable technical scheme, the wet tissue carrier is any one of non-woven fabrics, cotton fabrics, gauze and wet strength paper.

As a preferable technical scheme, the mass ratio of the wet tissue carrier to the bacteriostatic composition in the wet tissue is 1: (1-3).

The third aspect of the invention provides a method for preparing a wet tissue for wiping a surface of a material, which comprises the following steps:

(1) weighing the raw materials in the antibacterial composition, and fully dissolving the organosilicon quaternary ammonium salt and the polyhexamethylene guanidine hydrochloride in water at 35-50 ℃;

(2) adding the nano silver solution, the ginger extract, the aloe extract and the surfactant into the solution obtained in the step (1) and uniformly stirring to obtain the antibacterial composition;

(3) and soaking the wet tissue carrier in the antibacterial composition for 2-4 hours, taking out, sealing and packaging aseptically to obtain the wet tissue for wiping the object surface.

Has the advantages that: (1) the organosilicon quaternary ammonium salt has excellent bacteriostatic action and has synergistic action with the ginger extract and the aloe extract, so that the product has broad-spectrum continuous bacteriostatic and antibacterial properties; (2) according to the invention, the organosilicon quaternary ammonium salt and the nano-silver are used as main antibacterial components and are compounded with a certain proportion of surfactant, so that the product still keeps the effect of inhibiting the growth of bacteria after being washed with water for 50 times; (3) the wet tissue carrier is soaked in the antibacterial composition, does not have chemical reaction, is soft and smooth, and ensures that the wet tissue has excellent skin feel; (4) the natural plant extract is used as an active ingredient, is mild and not irritant, and is not added with preservative, essence, ethanol and other ingredients, so that the skin is moisturized and protected, and is more moist while inhibiting bacteria, so that the product is higher in safety and wide in applicability.

Detailed Description

The technical features of the technical solutions provided by the present invention are further clearly and completely described below with reference to the specific embodiments, and the scope of protection is not limited thereto.

The words "preferred", "more preferred", and the like, in the present invention refer to embodiments of the invention that may provide certain benefits, under certain circumstances. However, other embodiments may be preferred, under the same or other circumstances. Furthermore, the recitation of one or more preferred embodiments does not imply that other embodiments are not useful, nor is it intended to exclude other embodiments from the scope of the invention.

When a range of values is disclosed herein, the range is considered to be continuous and includes both the minimum and maximum values of the range, as well as each value between such minimum and maximum values. Further, when a range refers to an integer, each integer between the minimum and maximum values of the range is included. Further, when multiple range-describing features or characteristics are provided, the ranges may be combined. In other words, unless otherwise indicated, all ranges disclosed herein are to be understood to encompass any and all subranges subsumed therein. For example, a stated range from "1 to 10" should be considered to include any and all subranges between the minimum value of 1 and the maximum value of 10. Exemplary subranges of the range 1 to 10 include, but are not limited to, 1 to 6.1, 3.5 to 7.8, 5.5 to 10, and the like.

Preferably, the paint comprises the following components in percentage by weight: 18-22% of organosilicon quaternary ammonium salt, 4-7% of polyhexamethylene guanidine hydrochloride, 0.2-0.4% of ginger extract, 0.05-1% of aloe extract, 0.5-2% of surfactant and the balance of water.

Preferably, the water is RO pure water.

Preferably, the bacteriostatic composition further comprises nano silver.

Preferably, the concentration of the nano silver in the bacteriostatic composition is 500-5000 ppm.

Preferably, the average particle size of the nano silver is 1-10 nm; more preferably, the average particle size of the nano silver is 1-5 nm; most preferably, the average particle size of the nano silver is 2 nm.

Preferably, the organosilicon quaternary ammonium salt is an organosilicon quaternary ammonium salt containing C18-C30 carbon chains.

Examples of dimethyl alkyl [3- (trimethoxysilyl) propyl ] ammonium halides as C18-C30 carbon chain include, but are not limited to: dimethyldodecyl [3- (trimethoxysilyl) propyl ammonium halide, dimethylhexadecyl [3- (trimethoxysilyl) propyl ammonium halide, dimethyloctadecyl [3- (trimethoxysilyl) propyl ammonium halide. Wherein the halogen is one or more of fluorine, chlorine, bromine and iodine.

More preferably, the organosilicon quaternary ammonium salt is dimethyl octadecyl [3- (trimethoxysilyl) propyl ammonium chloride.

The ginger extract and the aloe extract can be obtained by market or conventional means, and the market sources of the ginger extract and the aloe extract are not limited in any way.

Preferably, the surfactant is selected from one or more of dodecyl dimethyl benzyl ammonium chloride, dodecyl dimethyl benzyl ammonium bromide, tetradecyl dimethyl benzyl ammonium chloride, and tetradecyl dimethyl benzyl ammonium bromide.

More preferably, the surfactant further comprises Gemini (Gemini) quaternary ammonium salt of type 12-3-12.

Preferably, the Gemini quaternary ammonium salt is selected from 12-n-12 type Gemini quaternary ammonium salt or 16-n-16 type Gemini quaternary ammonium salt, wherein n is 2, 3, 4 or 6.

Most preferably, the surfactant is dodecyl dimethyl benzyl ammonium chloride and Gemini (Gemini) quaternary ammonium salt of type 12-3-12.

The 12-3-12 type Gemini (Gemini) quaternary ammonium salt is Gemiqi hydrophilic series, YND 1233.

Most preferably, the surfactant is dodecyl dimethyl benzyl ammonium chloride and 12-3-12 type Gemini (Gemini) quaternary ammonium salt according to the mass ratio of 1: 1 compounding the obtained mixture.

The present invention will now be described in detail by way of examples, and the starting materials used are commercially available unless otherwise specified.

Examples

Example 1

Example 1 provides a bacteriostatic composition for a wet tissue, which comprises the following components in percentage by weight: 20% of organosilicon quaternary ammonium salt, 5% of polyhexamethylene guanidine hydrochloride, 0.3% of ginger extract, 0.2% of aloe extract, 1% of surfactant and the balance of water.

The bacteriostatic composition also comprises nano silver with the average particle size of 2nm, and the concentration of the nano silver in the bacteriostatic composition is 1000 ppm;

the organosilicon quaternary ammonium salt is dimethyl octadecyl [3- (trimethoxysilyl) propyl ammonium chloride;

the surfactant is dodecyl dimethyl benzyl ammonium chloride and 12-3-12 type Gemini (Gemini) quaternary ammonium salt according to the mass ratio of 1: 1 compounding the obtained mixture.

The water is RO pure water.

Example 1 also provides a method of making a wet wipe for surface wiping comprising the steps of:

(1) weighing the raw materials in the antibacterial composition, and fully dissolving the organosilicon quaternary ammonium salt and the polyhexamethylene guanidine hydrochloride in water at 40 ℃;

(3) and (3) soaking the non-woven fabric in the antibacterial composition for 3 hours, taking out the non-woven fabric, sealing and packaging aseptically to obtain the wet tissue for wiping the object surface.

The wet tissue of the embodiment of the invention adopts ASTM G21-13 to measure the antibacterial effect, and the types of the bacteria are as follows: ATTCC16404, AS 3.3601, AS 3.3875. The standard is as follows: 0, no growth bacteria; 1, the growth range is less than 5 percent; 2, the growth range is between 5 and 10 percent; 3, the growth range is between 10 and 30 percent; 4 growth range greater than 30%, results are shown in the following table:

comparative example 1

Comparative example 1 provides a bacteriostatic composition for a wet wipe, comprising the following components in percentage by weight: 20% of organosilicon quaternary ammonium salt, 5% of polyhexamethylene guanidine hydrochloride, 0.3% of ginger extract, 0.2% of aloe extract, 0% of surfactant and the balance of water.

The water is RO pure water.

Comparative example 1 also provides a method of making a wet wipe for surface wiping comprising the steps of:

The wet wipe of comparative example 1 of the present invention was tested for antimicrobial efficacy using ASTM G21-13, the types of bacteria being: ATTCC16404, AS 3.3601, AS 3.3875. The standard is as follows: 0, no growth bacteria; 1, the growth range is less than 5 percent; 2, the growth range is between 5 and 10 percent; 3, the growth range is between 10 and 30 percent; 4 growth range greater than 30%, results are shown in the following table:

bacterial strain	Extent of growth
		Aspergillus niger (ATTCC16404)	3
Chaetomium globosum (AS 3.3601)	2
		Penicillium funiculosum (AS3.3875)	2

Comparative example 2

Comparative example 2 provides a bacteriostatic composition for a wet wipe, comprising the following components in percentage by weight: 20% of organosilicon quaternary ammonium salt, 5% of polyhexamethylene guanidine hydrochloride, 0.3% of ginger extract, 0.2% of aloe extract, 1% of surfactant and the balance of water.

the surfactant is dodecyl dimethyl benzyl ammonium chloride.

The water is RO pure water.

Comparative example 2 also provides a method of making a wet wipe for surface wiping comprising the steps of:

The wet wipe of comparative example 2 of the present invention was tested for antimicrobial efficacy using ASTM G21-13, the types of bacteria being: ATTCC16404, AS 3.3601, AS 3.3875. The standard is as follows: 0, no growth bacteria; 1, the growth range is less than 5 percent; 2, the growth range is between 5 and 10 percent; 3, the growth range is between 10 and 30 percent; 4 growth range greater than 30%, results are shown in the following table:

bacterial strain	Extent of growth
		Aspergillus niger (ATTCC16404)	1
Chaetomium globosum (AS 3.3601)	0
		Penicillium funiculosum (AS3.3875)	1

Comparative example 3

Comparative example 3 provides a bacteriostatic composition for a wet tissue, comprising the following components in percentage by weight: 20% of organosilicon quaternary ammonium salt, 5% of polyhexamethylene guanidine hydrochloride, 0.3% of ginger extract, 0.2% of aloe extract, 1% of surfactant and the balance of water.

the surfactant is 12-3-12 type Gemini (Gemini) quaternary ammonium salt.

The water is RO pure water.

Comparative example 3 also provides a method of making a wet wipe for surface wiping comprising the steps of:

The wet wipe of comparative example 3 of the present invention was tested for antimicrobial efficacy using ASTM G21-13, the types of bacteria being: ATTCC16404, AS 3.3601, AS 3.3875. The standard is as follows: 0, no growth bacteria; 1, the growth range is less than 5 percent; 2, the growth range is between 5 and 10 percent; 3, the growth range is between 10 and 30 percent; 4 growth range greater than 30%, results are shown in the following table:

bacterial strain	Extent of growth
		Aspergillus niger (ATTCC16404)	2
Chaetomium globosum (AS 3.3601)	1
		Penicillium funiculosum (AS3.3875)	1

Claims

1. The bacteriostatic composition for the wet tissue is characterized by comprising the following components in percentage by weight: 15-25% of organosilicon quaternary ammonium salt, 3-8% of polyhexamethylene guanidine hydrochloride, 0.1-0.5% of ginger extract, 0.01-1% of aloe extract, 0.5-5% of surfactant and the balance of water.

2. The bacteriostatic composition for the wet tissue as claimed in claim 1, which comprises the following components in percentage by weight: 18-22% of organosilicon quaternary ammonium salt, 4-7% of polyhexamethylene guanidine hydrochloride, 0.2-0.4% of ginger extract, 0.05-1% of aloe extract, 0.5-2% of surfactant and the balance of water.

3. The bacteriostatic composition for wet tissues according to claim 1 or 2, wherein the bacteriostatic composition further comprises nano silver.

4. The bacteriostatic composition for wet tissues as claimed in claim 3, wherein the concentration of the nano-silver in the bacteriostatic composition is 500-5000 ppm.

5. The bacteriostatic composition for wet tissues according to claim 4, wherein the average particle size of the nano-silver is 1-10 nm.

6. The bacteriostatic composition for the wet tissue as claimed in any one of claims 1 to 5, wherein the quaternary ammonium silicone salt is a quaternary ammonium silicone salt with C18-C30 carbon chains.

7. A wet wipe for surface wiping comprising a wet wipe carrier and the bacteriostatic composition of any one of claims 1-6.

8. The wet wipe for wiping a surface of a material as set forth in claim 7, wherein the carrier of the wet wipe is any one of a nonwoven fabric, a cotton fabric, a gauze, and a wet strength paper.

9. The wet wipe for wiping a surface of a body as claimed in claim 8, wherein the mass ratio of the wet wipe carrier to the bacteriostatic composition in the wet wipe is 1: (1-3).

10. A method of making a wet wipe for physical surface wiping according to any one of claims 7 to 9, comprising the steps of: