CN113908092B - Skin acne-removing and oil-controlling soluble beautifying microneedle patch composition and preparation method thereof - Google Patents
Skin acne-removing and oil-controlling soluble beautifying microneedle patch composition and preparation method thereof Download PDFInfo
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- CN113908092B CN113908092B CN202111273756.XA CN202111273756A CN113908092B CN 113908092 B CN113908092 B CN 113908092B CN 202111273756 A CN202111273756 A CN 202111273756A CN 113908092 B CN113908092 B CN 113908092B
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Abstract
The invention discloses a skin acne-removing and oil-controlling soluble beautifying microneedle patch composition and a preparation method thereof. The microneedle patch composition comprises a base, a needle body positioned on the base and a hydrogel patch for relieving and fixing the needle body, wherein the needle body is internally embedded with a skin acne-removing and oil-controlling composition: 0.01-0.2% of polyquaternium-73, 0.5-5% of radix sophorae flavescentis extract, 0.1-5% of nicotinamide and 0.1-1% of dipotassium glycyrrhizinate. The acne-removing efficacy composition is specially designed aiming at the complex pathogenesis of acne, has the effects of inhibiting various acne-causing fungi, relieving acne inflammation, reducing oxidative damage of cells and achieving allergy-relieving, and can also inhibit melanin formation, lighten skin color, lighten acne marks and restore natural luster of skin. The acne-removing efficacy composition is wrapped by the soluble beauty microneedle, so that not only can the acne-removing efficacy composition be better absorbed through skin and exert a good acne-removing effect, but also the acne-removing agent is facilitated to be released more slowly, and the acne-removing composition has excellent efficacy on acne muscles and is easy to use.
Description
Technical Field
The invention relates to a skin care product and a preparation method thereof, belongs to the technical field of daily chemicals, and in particular relates to a skin acne-removing and oil-controlling soluble beautifying microneedle patch composition and a preparation method thereof.
Background
Many people are afflicted with acne, which is commonly known as acne in medicine. Acne is a chronic inflammation of hair follicles and sebaceous glands, and mainly occurs in the facial and thoracodorsal fatty areas, which not only affects the appearance, but also affects the health.
In addition to genetic factors, acne is also closely related to the characteristics of puberty. The pathogenesis of acne is mainly as follows:
(1) sebaceous gland hypertrophy. The increased secretion of androgens in the body can lead to hyperplasia and hypertrophy of sebaceous glands, so that the increased secretion of sebum is caused, and sebum which cannot be completely discharged is accumulated in follicular orifices to form acne.
(2) Hyperkeratosis of the follicular orifice. Androgens also cause excessive keratinization of the hair follicle epithelium and sebaceous gland ducts, causing increased shedding of hair follicle wall epithelial cells, and sebum accumulated at the follicular orifice to mix together, forming an embolism, which is then gradually dried, oxidized and contaminated to darken, forming comedones.
(3) As the hair follicle is blocked, a weak acid anaerobic environment which is very suitable for the propagation and aggregation of anaerobic propionibacteria acnes is formed in the hair follicle, so that the anaerobic propionibacteria acnes in the hair follicle are increased and decompose sebum in a large amount to form a large amount of free fatty acid, the hair follicle wall is destroyed, and the inflammation of connective tissues around the hair follicle is caused.
In addition, acne is aggravated by endocrine disorders, facial cleanliness and hygiene, eating habits, long-term mental stress, and other factors.
In the prior market, the acne-removing product is usually prepared by adding components with oil control or antibacterial effects into skin care products. However, most components with oil control or antibacterial effects are easy to stimulate skin or destroy normal flora on the surface layer of skin, so that skin barrier is easy to damage, the moisturizing ability of skin is reduced, and the water-oil balance of skin is disturbed, so that acne is easy to repeat, and the absorption rate of effective active substances in the external skin care product is generally less than 10%.
Disclosure of Invention
In order to overcome the problems in the prior art, the invention aims to provide the skin acne-removing and oil-controlling soluble beautifying microneedle film composition, and the acne-removing efficacy composition is wrapped by adopting the soluble beautifying microneedle, so that the composition can be absorbed transdermally to play a good acne-removing role, is beneficial to more slow release of an acne-removing agent, has excellent efficacy on acne muscles and is easy to use.
The invention also aims to provide a preparation method of the skin acne-removing and oil-controlling soluble beautifying microneedle film composition, which is simple, low in energy consumption and low in production cost, and is easy to realize continuous mass production.
The invention is realized by adopting the following technical scheme.
A skin acne-removing and oil-controlling soluble beautifying microneedle patch composition comprises a base, a needle body positioned on the base and a hydrogel patch for relieving and fixing the needle body; the skin acne-removing and oil-controlling composition is embedded in the needle body, and comprises the following components in percentage by weight:
0.01 to 0.2 percent of polyquaternium-73, 0.5 to 5 percent of kuh-seng extract, 0.1 to 5 percent of nicotinamide and 0.1 to 1 percent of dipotassium glycyrrhizinate.
Preferably, the skin acne-removing and oil-controlling composition comprises the following components in percentage by weight according to the total weight of the microneedle:
0.05 to 0.15 percent of polyquaternium-73, 0.5 to 3 percent of kuh-seng extract, 0.1 to 3 percent of nicotinamide and 0.1 to 0.8 percent of dipotassium glycyrrhizinate.
Preferably, the skin acne-removing and oil-controlling composition further comprises the following components in percentage by weight:
5-15% of glycerol, 2-5% of low molecular weight sodium hyaluronate and 10-15% of high molecular weight sodium hyaluronate.
Preferably, the soluble beauty micro-needles are conical, the main component is hyaluronic acid, the length of the needle head is 150-450 mu m, the distance between the micro-needles is 400-700 mu m, and the whole dry sheet comprises 1500-4500 hyaluronic acid microcrystal struts.
Preferably, the hydrogel adhesive film has 4 layers and 15-25 components. The hydrogel film comprises non-woven fabrics, hydrogel body, active component layer and protective film from top to bottom.
The non-woven fabric is non-woven fabric and is formed by solidifying high polymer slices, short fibers or filaments.
The hydrogel body comprises the following specific components in percentage by weight: 5-15% of glycerin, 1-2% of sodium polyacrylate, 1-3% of dihydroxyglycine aluminum, 0.5-2% of cellulose gum, 1-5% of tartaric acid, 5-15% of butanediol and 50-80% of water.
The active component layers are specifically as follows, based on the total weight of the hydrogel patch:
0.1-2% of centella asiatica extract, 0.2-3% of polygonum cuspidatum root extract, 0.2-3% of scutellaria baicalensis root extract, 0.1-2% of tea leaf extract, 0.2-3% of glycyrrhiza glabra root extract, 0.3-1% of chamomile flower extract and 0.1-2% of rosemary leaf extract.
The protective film is in particular a white plastic film.
In another aspect, the invention provides a method for preparing a skin acne-removing, oil-controlling and soluble cosmetic microneedle patch composition, which comprises the following steps:
1) Preparation of viscous liquid:
adding the skin acne-removing and oil-controlling composition into the rest water, stirring for dissolving, adding 5-15% of glycerin, 2-5% of sodium hyaluronate (low molecular weight) and 10-15% of sodium hyaluronate (high molecular weight), continuously stirring to make it swell uniformly, centrifuging and removing air bubbles to obtain the viscous liquid.
2) Preparation of soluble cosmetic microneedles:
and (3) injecting the viscous liquid into a microneedle mould, drying and demoulding to obtain the soluble beauty microneedle.
3) Preparation of hydrogel adhesive film:
uniformly mixing 1-2% of sodium polyacrylate and 1-3% of dihydroxyglycine aluminum, adding 5-15% of glycerol and 5-15% of butanediol, and fully stirring to obtain a phase A solution; adding 0.5-2% cellulose gum into water, stirring, adding 1-5% tartaric acid, adding active component layer, stirring to dissolve completely to obtain phase B solution; adding the B phase solution into the A phase solution, stirring in vacuum to obtain hydrogel paste, and finally coating with non-woven fabrics and protective films on a coating machine to obtain the hydrogel film.
Preferably, in step 1), the molecular weight of the low molecular weight sodium hyaluronate is 2000 to 10000 daltons; the molecular weight of the high molecular weight sodium hyaluronate is 40-100 ten thousand daltons.
The mass ratio of the high molecular weight sodium hyaluronate to the low molecular weight sodium hyaluronate is 1:3.0-5.0.
Preferably, in step 2), the microneedle mould comprises a square, rectangular or circular shape.
Preferably, the drying temperature is room temperature, the humidity is 15-25%, and the drying time is 12-24h.
Preferably, in the step 3), the stirring speed of the vacuum stirring is 50-120r/min, and the stirring time is 5-15min.
By means of the technical scheme, the invention has the following beneficial technical effects:
1) The acne-removing efficacy composition is specially designed aiming at the complex pathogenesis of acne, has the effects of inhibiting various acne-causing fungi, relieving acne inflammation, reducing oxidative damage of cells and achieving allergy-relieving, and can also inhibit melanin formation, lighten skin color, lighten acne marks and restore natural luster of skin.
2) The acne-removing efficacy composition is wrapped by the soluble beauty microneedle, so that not only can the acne-removing efficacy composition be better absorbed through skin and exert a good acne-removing effect, but also the acne-removing agent is facilitated to be released more slowly, and the acne-removing composition has excellent efficacy on acne muscles and is easy to use.
Drawings
Fig. 1 is a structural diagram of a skin acne-removing and oil-controlling soluble beauty microneedle provided by the invention.
Fig. 2 is a microarray view of a skin acne-removing, oil-controlling and soluble cosmetic microneedle provided by the invention.
Detailed Description
The technical scheme of the invention is further specifically described through specific examples. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.
As shown in fig. 1, the invention discloses a skin acne-removing and oil-controlling soluble beauty microneedle patch composition and a preparation method thereof. The microneedle patch composition comprises a base, a needle body positioned on the base and a hydrogel patch for relieving and fixing the needle body, wherein the base consists of hyaluronic acid. The skin acne-removing and oil-controlling composition is embedded in the needle body, and comprises the following components:
0.01 to 0.2 percent of polyquaternium-73, 0.5 to 5 percent of kuh-seng extract, 0.1 to 5 percent of nicotinamide and 0.1 to 1 percent of dipotassium glycyrrhizinate.
The hydrogel film comprises non-woven fabrics, hydrogel body, active component layer and protective film from top to bottom. The function of the non-woven fabric is to improve the air permeability of the film, the function of the hydrogel body is to lock water for a long time, the function of the active component layer is to slowly release water, assist in moisturizing and relieving irritation resistance, and the function of the protective film is to prevent the loss of gel nutrition and water.
As shown in figure 2, the soluble beauty micro-needle is conical, the main component is hyaluronic acid, the length of the needle head is 150-450 mu m, the distance between the micro-needles is 400-700 mu m, and the whole dry sheet comprises 1500-4500 hyaluronic acid microcrystal struts.
The following focuses on the efficacy of the ingredients of the compositions.
(1) Polyquaternium-73
Polyquaternium-73 is an acne, acne inhibitor (destroying bacterial fungal cell membrane, having excellent effect on propionibacterium acnes) with antibacterial activity; can also inhibit melanin formation; high efficiency and high safety.
(2) Radix Sophorae Flavescentis extract
The kuh-seng ether extract and the alcohol extract have strong antibacterial effect on staphylococcus aureus, and matrine can reduce the release of allergic medium and has antiallergic effect. The kuh-seng can balance grease secretion, dredge and astringe pores, remove skin endotoxin impurities, enrich herbal nutrition, promote growth and repair of damaged vascular nerve cells, restore activity of subcutaneous capillary cells, and enable skin to reappear, tighten, thin and smooth, thereby playing a role in beautifying and protecting skin.
(3) Nicotinamide
The nicotinamide is used as a derivative of vitamin B3, can down regulate the transfer of melanosomes from melanocytes to keratinocytes, interfere cell signal channels between the keratinocytes and the melanocytes, reduce melanin generation, act on generated melanin, reduce transfer of the generated melanin to surface cells, and achieve the whitening effect. Researches show that when the concentration of nicotinamide reaches 2%, the production of triglyceride and fatty acid in skin can be effectively reduced, and the effects of controlling oil and whitening are realized. When the concentration of nicotinamide reaches 4%, the product has a certain vaccinia muscle care effect.
(4) Dipotassium glycyrrhizinate
Dipotassium glycyrrhizinate is used as a skin conditioner, is mainly glycyrrhizin (glycyrrhizic acid) components of roots and stems of liquorice, is suitable for allergic skin, has the functions of resisting stimulation, controlling oil, removing inflammation, diminishing inflammation and healing, can effectively prevent sensitive inflammation phenomenon when skin is stimulated, has the function of diminishing inflammation and calming inflammation caused by sunlight, and is often used in antiallergic and repairing cosmetics.
Therefore, the composition formed by combining the four components is specially designed for complex pathogenesis of acne, has the effects of inhibiting various acne-causing fungi, relieving vaccinia inflammation, reducing oxidative damage of cells and achieving allergy, and can also inhibit melanin formation, lighten skin color, lighten acne marks and restore natural luster of skin.
The acne-removing efficacy composition is wrapped by the soluble beauty microneedle, so that not only can the acne-removing efficacy composition be better absorbed through skin and exert a good acne-removing effect, but also the acne-removing agent is facilitated to be released more slowly, and the acne-removing composition has excellent efficacy on acne muscles and is easy to use. The action mechanism of the micro-needle is that after the micro-needle is attached to the skin, the soluble micro-needle is injected into the skin, the acne removing and oil controlling composition of the skin is released along with the melting of the crystal, the melting of the crystal is slower, and the crystal is completely melted and released slowly in about two hours.
The following percentages are by weight. All raw material components of the invention are commercial products.
The preparation method of radix Sophorae Flavescentis extract comprises pulverizing radix Sophorae Flavescentis, sieving, accurately weighing a certain amount of radix Sophorae Flavescentis, extracting according to crude drug amount of 0.10g.mL-1, adding 50% butanediol water solution (mass fraction), extracting at 70-75deg.C, and filtering to obtain radix Sophorae Flavescentis extract.
The Sophora flavescens extract is purchased from Beijing university of Industrial and commercial, polyquaternium-73 is purchased from Tiancidi chemical industry, nicotinamide is purchased from Disman, and dipotassium glycyrrhizinate is purchased from Orly industries, inc. Centella asiatica extract, polygonum cuspidatum root extract, scutellaria baicalensis root extract, tea extract, glycyrrhiza glabra root extract, chamomile flower extract and rosemary leaf extract are all purchased from Beijing university or Galois leaf biotechnology limited.
Example 1
A preparation method of a skin acne-removing and oil-controlling soluble beauty microneedle patch composition comprises the following steps:
1) Preparation of viscous liquid:
adding 0.15% polyquaternium-73,1.5% radix Sophorae Flavescentis extract, 1% nicotinamide, 0.8% dipotassium glycyrrhizinate into the rest water, stirring for dissolving, adding 10% glycerol, 3% sodium hyaluronate (molecular weight of 5000 dalton) and 12% sodium hyaluronate (molecular weight of 60 dalton), stirring continuously to make it swell uniformly, centrifuging to remove air bubbles, and obtaining viscous liquid.
2) Preparation of soluble cosmetic microneedles:
injecting the viscous liquid into a round microneedle mould, drying for 20 hours at room temperature and humidity of 20%, and demoulding to obtain the soluble beauty microneedle.
3) Preparation of hydrogel adhesive film:
uniformly mixing 1.5% of sodium polyacrylate and 2% of dihydroxyglycine aluminum, adding 10% of glycerol and 10% of butanediol, and fully stirring to obtain a phase A solution;
adding 1% cellulose gum into water, stirring, adding 3% tartaric acid, adding 0.6% herba Centellae extract, 0.5% rhizoma Polygoni Cuspidati extract, 0.5% radix Scutellariae extract, 0.6% folium Camelliae sinensis extract, 0.8% radix Glycyrrhiza glabra extract, 0.8% flos Matricariae Chamomillae extract and 0.5% herba Rosmarini officinalis leaf extract, stirring to dissolve completely to obtain phase B solution;
adding the B phase solution into the A phase solution, stirring in vacuum to obtain hydrogel paste, wherein the stirring speed is 80r/min, the stirring time is 10min, and finally coating the hydrogel paste with non-woven fabrics and a protective film on a coating machine to obtain the hydrogel film.
Example 2
A preparation method of a skin acne-removing and oil-controlling soluble beauty microneedle patch composition comprises the following steps:
adding 0.1% polyquaternium-73, 1% radix Sophorae Flavescentis extract, 0.5% nicotinamide and 0.6% dipotassium glycyrrhizinate into the rest water, stirring for dissolving, adding 10% glycerol, 3% sodium hyaluronate (molecular weight is 5000 dalton) and 12% sodium hyaluronate (molecular weight is 60 dalton), continuing stirring to make it swell uniformly, centrifuging and removing air bubbles to obtain viscous liquid.
2) Preparation of soluble cosmetic microneedles:
as in example 1.
3) Preparation of hydrogel adhesive film:
as in example 1.
Example 3
A preparation method of a skin acne-removing and oil-controlling soluble beauty microneedle patch composition comprises the following steps:
1) Preparation of viscous liquid:
adding 0.05% polyquaternium-73,0.5% radix Sophorae Flavescentis extract, 0.2% nicotinamide and 0.3% dipotassium glycyrrhizinate into the rest water, stirring for dissolving, adding 10% glycerol, 3% sodium hyaluronate (molecular weight is 5000 dalton) and 12% sodium hyaluronate (molecular weight is 60 dalton), continuing stirring to make it swell uniformly, centrifuging and removing air bubbles to obtain viscous liquid.
2) Preparation of soluble cosmetic microneedles:
as in example 1.
3) Preparation of hydrogel adhesive film:
as in example 1.
Blank example 1
A preparation method of a skin acne-removing and oil-controlling soluble beauty microneedle patch composition comprises the following steps:
1) Preparation of viscous liquid:
adding 10% glycerol, 3% sodium hyaluronate (molecular weight of 5000 dalton) and 12% sodium hyaluronate (molecular weight of 60 kilodalton) into the rest water, stirring to swell uniformly, centrifuging to remove air bubbles, and obtaining viscous liquid.
2) Preparation of soluble cosmetic microneedles:
as in example 1.
3) Preparation of hydrogel adhesive film:
as in example 1.
Effect verification test example
1. Oil control efficacy test experiment
Skin oil content test:
test instrument: sebumeter SM815, manufactured by CK, germany.
Test conditions: constant temperature and humidity environment, temperature 23+ -1deg.C, humidity 50% + -5%, and subject was allowed to sit still for at least 30 minutes under the environment before testing.
80 subjects with oily skin, 40 men, 40 women were enrolled. The animals were randomly divided into four groups of 20 persons each.
Skin lipid content (μg/cm) on both sides of the nose of the subject was measured with a lipid tester Sebumeter SM815, respectively 2 ) Recorded as T0. After each subject washed his/her face, the skin anti-acne and oil-controlling soluble cosmetic microneedle patch compositions obtained in examples 1, 2, and 3 and blank 1 were applied to the face, particularly to both sides of the nose, once daily for 1 to 2 hours for 4 weeks. Skin lipid content on both sides of the nose of the subjects was measured with a lipid tester weekly and recorded as T1, T2, T3 and T4, respectively. The test results are shown in Table 1.
The results are shown in Table 1 below.
Table 1 test results
As can be seen from Table 1, the soluble cosmetic microneedle patch compositions containing skin acne-removing and oil-controlling compositions obtained in examples 1 to 3 of the present invention can effectively inhibit the secretion of grease, while the soluble cosmetic microneedle patch composition without skin acne-removing and oil-controlling composition obtained in blank example 1 has little effect of inhibiting the secretion of grease. The oil-control soluble cosmetic microneedle patch composition has the effect of controlling the acne of the skin.
2. Experimental example of synergistic effect
Comparative examples 1 to 14
The viscous liquid component ratios of the soluble cosmetic microneedle patch composition are shown in tables 2-3 below:
TABLE 2 viscous liquid composition (wt.%)
TABLE 3 viscous liquid composition (wt.%)
The preparation process was as described in example 1.
The oil control effect test was performed on example 1, comparative examples 1 to 14, and blank example 1.
Test instrument: sebumeter SM815, manufactured by CK, germany.
Test conditions: constant temperature and humidity environment, temperature 23+ -1deg.C, humidity 50% + -5%, and subject was allowed to sit still for at least 30 minutes under the environment before testing.
Subjects 160, men 80, women 80 with oily skin were recruited. The animals were randomly divided into 16 groups of 10 persons each.
Skin lipid content (μg/cm) on both sides of the nose of the subject was measured with a lipid tester Sebumeter SM815, respectively 2 ) Recorded as T0. After each subject washed his/her face, the skin acne-removing and oil-controlling soluble cosmetic microneedle patch compositions obtained in examples 1, 2, 3 and blank 1 were applied to the face, particularly to both sides of the nose, once a day for 1 to 2 hours for 4 weeks, and the fourth week oil content was recorded as T4. The test results are shown in table 3 below.
Table 4 test results
As can be seen from the test data in table 4, the oil control effect is ranked as example 1> comparative examples 11, 12, 13, 14> comparative examples 5, 6, 7, 8, 9, 10> comparative examples 1, 2, 3, 4, which demonstrates that the skin anti-acne and oil control composition has better oil control effect through the synergistic effect between the components than the single one, two or three component combination.
3. Human trial evaluation experiment
The experimental method comprises the following steps: the skin acne-removing, oil-controlling soluble cosmetic microneedle patch compositions prepared in examples 1, 2 and 3 and blank example 1 were selected as experimental samples, and trial evaluation was performed on volunteers, respectively. 80 volunteers with mild or moderate acne (25-45 years old) were selected, 40 men and women were randomly divided into 4 groups of 10 men and 10 women each. Samples of the skin acne-removing, oil-controlling, soluble cosmetic microneedle patch compositions prepared in examples 1, 2, 3 and blank 1 were used by 4 groups of volunteers, respectively.
The using method comprises the following steps: after the face is cleaned, the medicine is used once a day for 1-2 hours for 4 weeks continuously, and sensory evaluation is carried out according to the improvement condition of the acne.
The scoring standard is 1 minute-no effect, 2 minutes-effective, very weak, 3 minutes-effective, obvious in effect, 4 minutes-effective, better in effect, 5 minutes-effective, very good in effect. The score of more than or equal to 3 is judged to be obvious in effect, and the proportion of more than or equal to 3 in each group is counted. The results obtained are shown in Table 5:
table 5 test results
| Evaluation results | Has obvious acne removing effect | Has the effects of | Has no effect |
| Example 1 | 80％ | 15％ | 5％ |
| Example 2 | 55％ | 40％ | 5％ |
| Example 3 | 40％ | 50％ | 10％ |
| Blank example 1 | 0 | 10％ | 90％ |
As can be seen from Table 5, the skin acne-removing and oil-controlling soluble cosmetic microneedle patch compositions obtained in examples 1-3 of the present invention can effectively remove acne, and the effect is superior to that of the soluble cosmetic microneedle patch composition of blank example 1, which does not contain the skin acne-removing and oil-controlling composition.
In conclusion, the composition for removing acnes and controlling oil of the skin is specially designed for complex pathogenesis of acnes, has the effects of inhibiting various acne-causing fungi, relieving acne inflammation, reducing oxidative damage of cells and achieving comfort, and can also inhibit melanin formation, lighten skin color, lighten acne marks and restore natural luster of the skin. The acne-removing efficacy composition is wrapped by the soluble beauty microneedle, so that not only can the acne-removing efficacy composition be better absorbed through skin and exert a good acne-removing effect, but also the acne-removing agent is facilitated to be released more slowly, and the acne-removing composition has excellent efficacy on acne muscles and is easy to use. The hydrogel film is matched with the soluble micro-needles to be used, can release the water of the hydrogel film when the water is deficient, has self-adhesive property and low sensitization, can cover the soluble beauty micro-needles on the skin and is not easy to fall off, and ensures the stable play of the acne removing and oil controlling effects of the micro-needles.
The above description is only of the preferred embodiments of the present invention, and is not intended to limit the invention in any way, but other variations and modifications are possible without departing from the technical solution described in the claims.
Claims (7)
1. A skin acne-removing and oil-controlling soluble beauty microneedle patch composition is characterized in that: comprises a base, a needle body positioned on the base and a hydrogel film for relieving and fixing the action of the needle body;
the skin acne-removing and oil-controlling composition is embedded in the needle body, and comprises the following components in percentage by weight: 0.01 to 0.2 percent of polyquaternium-73, 0.5 to 5 percent of kuh-seng extract, 0.1 to 5 percent of nicotinamide and 0.1 to 1 percent of dipotassium glycyrrhizinate;
the hydrogel adhesive film consists of non-woven fabrics, hydrogel bodies, active components and a protective film;
the active components comprise the following specific components in percentage by weight:
0.1-2% of centella asiatica extract, 0.2-3% of polygonum cuspidatum root extract, 0.2-3% of scutellaria baicalensis root extract, 0.1-2% of tea leaf extract, 0.2-3% of glycyrrhiza glabra root extract, 0.3-1% of chamomile flower extract and 0.1-2% of rosemary leaf extract;
the specific components of the hydrogel body are as follows: 5-15% of glycerol, 1-2% of sodium polyacrylate, 1-3% of dihydroxyglycine aluminum, 0.5-2% of cellulose gum, 1-5% of tartaric acid, 5-15% of butanediol and 50-80% of water;
the skin acne-removing and oil-controlling soluble beautifying microneedle patch composition is prepared by the following steps:
1) Preparation of viscous liquid:
adding the skin acne-removing and oil-controlling composition into the rest water, stirring and dissolving, adding 5-15% of glycerin, 2-5% of low molecular weight sodium hyaluronate and 10-15% of high molecular weight sodium hyaluronate, continuously stirring to make the skin acne-removing and oil-controlling composition swell uniformly, centrifuging and removing air bubbles to obtain viscous liquid; the molecular weight of the low molecular weight sodium hyaluronate is 2000-10000 daltons; the molecular weight of the high molecular weight sodium hyaluronate is 40-100 ten thousand daltons; the mass ratio of the high molecular weight sodium hyaluronate to the low molecular weight sodium hyaluronate is 1:3.0-5.0;
2) Preparation of soluble cosmetic microneedles:
injecting the viscous liquid into a microneedle mould, drying and demoulding to obtain a soluble beauty microneedle;
3) Preparation of hydrogel adhesive film:
uniformly mixing 1-2% of sodium polyacrylate and 1-3% of dihydroxyglycine aluminum, adding 5-15% of glycerol and 5-15% of butanediol, and fully stirring to obtain a phase A solution; adding 0.5-2% cellulose gum into water, stirring, adding 1-5% tartaric acid, adding active component, stirring to dissolve completely to obtain phase B solution; adding the B phase solution into the A phase solution, stirring in vacuum to obtain hydrogel paste, and finally coating with non-woven fabrics and protective films on a coating machine to obtain the hydrogel film.
2. The skin acne-removing, oil-controlling, soluble cosmetic microneedle patch composition of claim 1, wherein: the skin acne-removing and oil-controlling composition comprises the following components in percentage by weight according to the total weight of the microneedle:
0.05 to 0.15 percent of polyquaternium-73, 0.5 to 3 percent of kuh-seng extract, 0.1 to 3 percent of nicotinamide and 0.1 to 0.8 percent of dipotassium glycyrrhizinate.
3. The skin acne-removing, oil-controlling, soluble cosmetic microneedle patch composition of claim 1, wherein:
the non-woven fabric is non-woven fabric and is formed by solidifying high polymer slices, short fibers or filaments;
the protective film is specifically a white plastic film.
4. A method for preparing the skin acne-removing, oil-controlling and soluble cosmetic microneedle patch composition according to any one of claims 1 to 3, which is characterized in that: the method comprises the following steps:
1) Preparation of viscous liquid:
adding the skin acne-removing and oil-controlling composition into the rest water, stirring and dissolving, adding 5-15% of glycerin, 2-5% of low molecular weight sodium hyaluronate and 10-15% of high molecular weight sodium hyaluronate, continuously stirring to make the skin acne-removing and oil-controlling composition swell uniformly, centrifuging and removing air bubbles to obtain viscous liquid; the molecular weight of the low molecular weight sodium hyaluronate is 2000-10000 daltons; the molecular weight of the high molecular weight sodium hyaluronate is 40-100 ten thousand daltons; the mass ratio of the high molecular weight sodium hyaluronate to the low molecular weight sodium hyaluronate is 1:3.0-5.0;
2) Preparation of soluble cosmetic microneedles:
injecting the viscous liquid into a microneedle mould, drying and demoulding to obtain a soluble beauty microneedle;
3) Preparation of hydrogel adhesive film:
uniformly mixing 1-2% of sodium polyacrylate and 1-3% of dihydroxyglycine aluminum, adding 5-15% of glycerol and 5-15% of butanediol, and fully stirring to obtain a phase A solution; adding 0.5-2% cellulose gum into water, stirring, adding 1-5% tartaric acid, adding active component layer, stirring to dissolve completely to obtain phase B solution; adding the B phase solution into the A phase solution, stirring in vacuum to obtain hydrogel paste, and finally coating with non-woven fabrics and protective films on a coating machine to obtain the hydrogel film.
5. The method for preparing the skin acne-removing, oil-controlling and soluble beautifying microneedle patch composition according to claim 4, which is characterized in that: in step 2), the microneedle mould comprises a square, rectangle or circle.
6. The method for preparing the skin acne-removing, oil-controlling and soluble beautifying microneedle patch composition according to claim 4, which is characterized in that: in the step 2), the drying temperature is room temperature, the humidity is 15-25%, and the drying time is 12-24h.
7. The method for preparing the skin acne-removing, oil-controlling and soluble beautifying microneedle patch composition according to claim 4, which is characterized in that: in the step 3), the stirring speed of the vacuum stirring is 50-120r/min, and the stirring time is 5-15min.
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| CN111481470A (en) * | 2020-06-09 | 2020-08-04 | 无锡元旭生物技术有限公司 | Hydrogel patch for soluble microneedle and preparation method thereof |
| CN111658590A (en) * | 2020-07-15 | 2020-09-15 | 泉后(广州)生物科技研究院有限公司 | Acne-removing composition and application thereof |
| CN113081894A (en) * | 2021-05-06 | 2021-07-09 | 无锡元旭生物技术有限公司 | Soluble noninvasive acne-removing microneedle patch and preparation method thereof |
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| CN111481470A (en) * | 2020-06-09 | 2020-08-04 | 无锡元旭生物技术有限公司 | Hydrogel patch for soluble microneedle and preparation method thereof |
| CN111658590A (en) * | 2020-07-15 | 2020-09-15 | 泉后(广州)生物科技研究院有限公司 | Acne-removing composition and application thereof |
| CN113081894A (en) * | 2021-05-06 | 2021-07-09 | 无锡元旭生物技术有限公司 | Soluble noninvasive acne-removing microneedle patch and preparation method thereof |
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