CN103251530B - Moderate skin cream containing multiple kinds of pure natural plant extracts - Google Patents

Abstract

The invention discloses a moderate skin cream containing multiple kinds of pure natural plant extracts. A pure natural green tea extract, a liquorice root extract, a rosmarinus officinalis leaf extract, a scutellaria baicalensis root extract, a chrysanthemum extract and a centella asiatica extract are added in raw materials of the skin cream, and all have effects of resisting inflammation and adjusting immunity; the skin cream is capable of completely inhibiting a dozen of inflammatory factors, rapidly stopping skin inflammations caused by various reasons and inhibiting malignant linkage physiological reactions in all stages of the inflammations, has an effect of sephalosprins and is safe without side effects, also has cooperative effects of resisting oxidization, soothing and preserving moisture, and especially has a remarkable clinical effect for nursing of sensitive skin and skin of infants; and the six kinds of selected pure natural plant extracts are added in the skin cream, so that the symptoms such as inflammation and allergies caused by factors such as climate, environment and stimulating substances of the infants can be greatly reduced, the tender and lovely skin of the infants is protected, and thus the moderate skin cream is suitable for being used by the infants.

Description

A kind of protective skin cream containing plant extract

Technical field

The present invention relates to a kind of protective skin cream.Specifically refer to a kind of protective skin cream containing plant extract.

Background technology

Infant skin resistance against diseases is poor, easily be infected by bacterial: due to skin undeveloped mature, so function of immune system is weak, the first line of defence of human body opposing pathogenic bacterium can not be become as adult, one deck natural acidic film only by skin surface protects skin, be easy to be infected by bacterial, or anaphylaxis occur, as erythema, erythema, blister etc.; Be rich in substrate in skin connective tissue, water content higher than adult, being easily inflamed property edema; Simultaneously rich blood vessel is wherein but very fragile, and stimulating by slight physical property will bleeding due to trauma.The skin of baby only has the thickness of adult skin 1/10th, epidermis to be cell monolayers, and adult is multi-layer cellular; Collagen fiber in corium are few, lack flexibility, and are not only easily permeated by foreign object, and easily because friction causes skin damage.The horny layer of infant skin is not yet reached maturity, corium and fibrous tissue thinner, skin is very young tender, responsive, opposing dry environment ability more weak.The skin of child is all different with the skin of adult on 26S Proteasome Structure and Function.Age is less, and difference is larger.Child skin outward appearance is level and smooth, delicate, texture is unclear, some physical properties, chemical, mechanicalness, biological invasion and attack resistivity are more weak to external world, therefore, research and develop a applicable baby to use, gentle, moist, nothing allergy, antiallergic formula the special skin-protection product of baby is research purpose of the present invention.

Summary of the invention

The invention reside in and a kind of gentle protective skin cream containing multiple pure natural plant extract such as Herba Centellae extract, scutellariae,radix extract and green tea extracts is provided, character gentleness, low stimulation, be applicable to baby and use.

Concrete technical scheme of the present invention is as follows:

A protective skin cream containing plant extract, the method being prepared cream by the raw material routine of following ratio is prepared from:

Emulsifying agent: cetearyl glucoside 1%-3%,

Lauryl alcohol phosphate ester potassium 0.1%-1%,

Cetearyl alcohol 1%-3%,

Skin moistening oils and fats: IPIS 3%-4%,

Hydrogenated palm oil glycerides 1%-3%,

Fructus oleae europaeae fruit oil 1%-3%,

Lanoline 0.4%-0.6%,

Wetting agent: polyglycereol 4%-10%,

Hyaluronate sodium 0.03%-0.06%,

Thickening agent: carbomer 0.15%-0.3%,

Antiseptic: methyl hydroxybenzoate and Methylisothiazolinone 0.1%-0.3%,

PH value regulator: triethanolamine 0.15%-0.2%,

Natural plant extracts: Herba Centellae extract 0.1%-2%, scutellariae,radix extract 0.1%-2%, green tea extract 0.1%-2%, Flos Chrysanthemi extract 0.1%-2%, licorice root extract 0.1%-2%, rosemary leaf extract 0.1%-2%; Described extract is that conveniently chemistry or physical chemistry separation method extract gained to the Herba Centellae after clean, scutellariae,radix, green tea, Flos Chrysanthemi, licorice, leaf of Herba Rosmarini Officinalis, and the relative density of described Herba Centellae extract, scutellariae,radix extract, green tea extract, Flos Chrysanthemi extract, licorice root extract is 0.9-1.1;

Described raw material also comprises: antioxidant: vitamin E 0.15%-0.25%,

Functional additive: allantoin 0.15-0.3%,

Skinfeel improving agent: polydimethylsiloxane 0.5%-1.5%,

Chelating agen: disodiumedetate 0.04%-0.06%,

Surplus is deionized water.

The invention has the advantages that:

The present invention is added with Herba Centellae extract, scutellariae,radix extract, green tea extract, Flos Chrysanthemi extraction, licorice root extract, has antiinflammatory and immunomodulatory effect; Tens kinds of inflammatory factors can be suppressed the most all sidedly, the scytitis that quick prevention causes due to a variety of causes (comprising internal cause), the pernicious chain physiological reaction in each stage of inflammation-inhibiting, there is class effects of antibiotics and have no side effect safely, also there is antioxidation simultaneously, releive and the cooperative effect of moisturizing, especially have obvious clinical effectiveness for allergic skin and infant skin nursing; The symptom such as inflammation, allergy that baby causes because of factors such as weather, environment, pungents can also be reduced, protect the tender and lovely skin of baby.The present invention also has the advantage low and low to the stimulation degree of eyes to the stimulation degree of skin.

Detailed description of the invention

Aqueous Phase Raw Material is prepared:

72.5Kg deionized water is injected corresponding aqueous phase reactions still, turn on agitator, adopt the rotating speed of 50R/min, be slowly sprinkled in kettle by 0.2Kg carbomer, stirring 2 is little of completely transparent, is heated to 80-85 DEG C and keeps.Then continue

Stir and add 0.05Kg disodiumedetate, 8Kg Natrulon H-10,0.5Kg lauryl alcohol phosphate ester potassium, 0.05Kg

Hyaluronate sodium, maintains the temperature at 80 DEG C-85 DEG C, makes Aqueous Phase Raw Material dissolve rear stopping completely and stirs and heating.

Oil phase preparation of raw material:

2.5Kg cetearyl glucoside, 4.0Kg IPIS, 2.5Kg cetearyl alcohol, 0.1Kg methyl hydroxybenzoate, 2.0Kg hydrogenated palm oil glycerides, 2.0Kg Fructus oleae europaeae fruit oil, 0.2Kg vitamin E, 0.5Kg lanoline, 1.0Kg polydimethylsiloxane are successively dropped in corresponding oil phase reactor, then heating is started, open when reaching certain flowing shape and stir, heat while stirring, slowly be heated to 80 DEG C-85 DEG C, stop when oil phase Raw is dissolved completely stirring and heating.

Mixing and emulsifying:

Open the vacuum system of vacuum emulsification pot, make vacuum emulsification pot be in the vacuum state of vacuum-0.07MPa, aqueous phase is mixed

Raw material in conjunction heating and stirring pot and the raw material in oil phase reactor suck in emulsifying pot by vacuum, keep the temperature in vacuum emulsification pot then to open vacuum emulsification pot agitator at 80 DEG C-85 DEG C and carry out homogenizing stirring, homogenizing speed of agitator 2500r/min, stirs 3min.

After homogenizing has stirred, adopt the rotating speed of 50R/min to continue to stir, and open vacuum system, make vacuum in vacuum emulsification pot be-0.06MPa, keep more than 80 DEG C emulsifying temperatures in vacuum emulsification pot to keep 30 minutes.

Add natural plant extracts:

Open vacuum emulsification pot cooling water valve, the emulsion in vacuum emulsification pot is allowed slowly to lower the temperature, add 0.2Kg triethanolamine simultaneously and regulate pH value. when material temperature is down to 45 DEG C, open the vacuum valve of vacuum emulsification pot, 0.2 Kg allantoin, 0.4Kg Herba Centellae extract, 0.4Kg scutellariae,radix extract, 0.4Kg green tea extract, 0.4Kg Flos Chrysanthemi extract, 0.4Kg licorice root extract, 0.4Kg rosemary leaf extract, 0.1Kg Methylisothiazolinone are added vacuum emulsification pot.Then stirring 15 minutes is continued.

Discharging:

Continue to stir cooling, open the vacuum system of vacuum emulsification pot simultaneously, make vacuum emulsification pot be in the vacuum state of vacuum-0.07MPa.Bubble in material is extracted.When material temperature is down to 35 DEG C, stop the vacuum stirring and put vacuum emulsification pot, discharging obtains protective skin cream.

(acute) skin irritation test:

Under the condition of relative humidity 60-70%, ambient temperature 20-24 DEG C, with it the Cavia porcellus protective skin cream that above method obtains being spread upon four body weight 250g-300g, Continuous Observation one week, every day every all there is not the phenomenon such as erythema, edema in Cavia porcellus.Through Fujian dream Guerlain day, Chemical Company entrusts Shanghai institute of Pharmaceutical Industry to test with regard to (acute) skin irritation of product, with it the Cavia porcellus this protective skin cream being spread upon four body weight 250g-300g, four Cavia porcelluss of smearing protective skin cream are at relative humidity 60-70%, live one week under the condition of ambient temperature 20-24 DEG C, after testing, every day every all there is not the phenomenon such as erythema, edema in Cavia porcellus; Stimulus intensity is classified as: have no irritative response.

Experimental result shows the stimulation degree of skin low.

The stimulation test of human eye:

The protective skin cream that above method obtains is diluted to the solution of 10 ﹪, and is maintained 37-38 DEG C, this test material is added drop-wise to gradually in an eye of tester, then sterile pure water is added drop-wise in the another eye of tester gradually.These research needs 10 testers.

Test according to random secondary ordered pair tester, and specify which kind of material to be also carry out in a random way to the material which eye drips and drips.A suitable test fluid is added drop-wise at leisure first eye of tester, then sterile water is added drop-wise to second eye at leisure.

In 30 seconds, or as quickly as possible dropping test material after, inquiry tester, utilize following standard to their eyes irriate feel carry out classification: 0=is within normal limit; 1=gentleness, very slight stimulation; The medium stimulation of 2=; Seriously stimulate with 3=.After 1/4 hour and 1 hour at dropping test material, inquire tester again, classification is carried out to the stimulation of eyes.

The eye irritation test of human body is carried out by obtained compositions.The result of research is as shown in the table.

Test group	Sample	To the grade of eye irritation	Sample	To the grade of eye irritation
					1	Protective skin cream is diluted to the solution of 10 ﹪	0	Sterile pure water	0
2	Protective skin cream is diluted to the solution of 10 ﹪	0	Sterile pure water	0
					3	Protective skin cream is diluted to the solution of 10 ﹪	0	Sterile pure water	0
4	Protective skin cream is diluted to the solution of 10 ﹪	0	Sterile pure water	0
					5	Protective skin cream is diluted to the solution of 10 ﹪	0	Sterile pure water	0
6	Protective skin cream is diluted to the solution of 10 ﹪	0	Sterile pure water	0
					7	Protective skin cream is diluted to the solution of 10 ﹪	0	Sterile pure water	0
8	Protective skin cream is diluted to the solution of 10 ﹪	0	Sterile pure water	0
					9	Protective skin cream is diluted to the solution of 10 ﹪	0	Sterile pure water	0
10	Protective skin cream is diluted to the solution of 10 ﹪	0	Sterile pure water	0

Test result shows that compositions is more serious unlike the stimulation of sterile pure water to eyes.

Green tea contains flavonoid, catechin, and catechin is a kind of effective anti-infective.And what in green tea, content was maximum is tea polyphenols, is rich in phenolic hydroxyl group in tea polyphenols structure, can provide active hydrogen, makes free radical deactivation, and the free radical of oxidized formation itself has higher stability due to catechol structure.Therefore tea polyphenols has the effect of scavenging free radicals and anti-lipid peroxidation.

Radix Glycyrrhizae has good whitening function, has the title of " whitening queen ", the activity of restraint of tyrosinase while that Radix Glycyrrhizae extract being anti-ultraviolet, and can also improve the skin of coarse, hydropenia, inflammation, is a kind of multi-functional whitening plant; Secondly, Radix Glycyrrhizae has stronger antiinflammatory and anti-metamorphosis, than sulfanilamide and antibiotic drug effect good; Moreover Radix Glycyrrhizae has the effect of good antioxidation and free radical resisting.

Have a kind of material being carnosol in Herba Rosmarini Officinalis, its moistening effect is remarkable.Experiment shows, smear skin after two weeks with the astringent containing this material, the moisture of skin can rise to 63% from 44%, and water evaporation quantity then drops to less than 13% from 21%, just as adding one natural cover for defense to skin, decrease much due to skin problem that hydropenia causes.

Radix Scutellariae has antioxidation, anticancer, antiviral, the pharmacological action such as antibacterial; There is the effect such as heat clearing and damp drying, eliminating fire and detoxication.

Flos Chrysanthemi is common plant, energy wind and heat dispersing, suppressing the hyperactive liver improving eyesight, its main component position volatile oil, flavonoid and aminoacid, trace element etc.Flos Chrysanthemi extract can affect the permeability of blood capillary, increases capillary resistance, therefore has significant antiinflammatory action; Secondly, Flos Chrysanthemi extract has obvious refrigeration function; Moreover Flos Chrysanthemi extract also has anti-aging effects.

Herba Centellae extract has the effect of outstanding healing of wound and cicatrix reparation, and its reason is that asiaticoside has and promotes interior collage synthesis and the important function such as new vascular generation, the growth of stimulation granulation, so be conducive to wound healing.Herba Centellae extract also has stronger antioxidation, can suppress free radical activity, and desalination melanin pigmentation, improves skin blood circulation, upgrades skin cell regeneration, helps the smooth metabolism of melanin to go out external.

These six kinds selected plant extracts out all can show antiinflammatory and immunomodulatory effect; Tens kinds of inflammatory factors can be suppressed the most all sidedly, the scytitis that quick prevention causes due to a variety of causes (comprising internal cause), the pernicious chain physiological reaction in each stage of inflammation-inhibiting, there is class effects of antibiotics and have no side effect safely, also there is antioxidation simultaneously, releive and the cooperative effect of moisturizing, especially have obvious clinical effectiveness for allergic skin and infant skin nursing.In this protective skin cream, add these six kinds of selected pure natural plant extract greatly can reduce the symptom such as inflammation, allergy that infant causes because of factors such as weather, environment, pungents, protect the tender and lovely skin of infant.

Claims (1)

1. the protective skin cream containing plant extract, is characterized in that: the method being prepared cream by the raw material routine of following ratio is prepared from:

Emulsifying agent: cetearyl glucoside 1%-3%,

Lauryl alcohol phosphate ester potassium 0.1%-1%,

Cetearyl alcohol 1%-3%,

Skin moistening oils and fats: IPIS 3%-4%,

Hydrogenated palm oil glycerides 1%-3%,

Fructus oleae europaeae fruit oil 1%-3%,

Lanoline 0.4%-0.6%,

Wetting agent: polyglycereol 4%-10%,

Hyaluronate sodium 0.03%-0.06%,

Thickening agent: carbomer 0.15%-0.3%,

Antiseptic: methyl hydroxybenzoate and Methylisothiazolinone 0.1%-0.3%,

PH value regulator: triethanolamine 0.15%-0.2%,

Natural plant extracts: Herba Centellae extract 0.1%-2%, scutellariae,radix extract 0.1%-2%, green tea extract 0.1%-2%, Flos Chrysanthemi extract 0.1%-2%, licorice root extract 0.1%-2%, rosemary leaf extract 0.1%-2%; Described extract is that conveniently chemistry or physical chemistry separation method extract gained to the Herba Centellae after clean, scutellariae,radix, green tea, Flos Chrysanthemi, licorice, leaf of Herba Rosmarini Officinalis, and the relative density of described Herba Centellae extract, scutellariae,radix extract, green tea extract, Flos Chrysanthemi extract, licorice root extract is 0.9-1.1;

Described raw material also comprises: antioxidant: vitamin E 0.15%-0.25%,

Functional additive: allantoin 0.15-0.3%,

Skinfeel improving agent: polydimethylsiloxane 0.5%-1.5%,

Chelating agen: disodiumedetate 0.04%-0.06%,

Surplus is deionized water.