CN111481470A - Hydrogel patch for soluble microneedle and preparation method thereof - Google Patents
Hydrogel patch for soluble microneedle and preparation method thereof Download PDFInfo
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- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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Abstract
The invention belongs to the technical field of skin care products, and particularly relates to a preparation method of a hydrogel patch for soluble microneedles, which comprises the steps of uniformly mixing a cross-linked framework and a cross-linking agent to obtain an A phase solution; adding the tackifier into water, stirring, adding the crosslinking regulator and the water-soluble functional component, and stirring until the crosslinking regulator and the water-soluble functional component are fully dissolved to obtain a B phase solution; adding the B phase solution into the A phase solution, and stirring in vacuum to obtain a hydrogel paste; the hydrogel paste was coated on a coater. The invention also provides a hydrogel patch for the soluble microneedle, which is obtained by the preparation method, and is used together with the soluble microneedle, because the hydrogel patch is a hydrophilic reticular polymer swelling body, the hydrogel patch can swell when meeting water, can release the water of the soluble microneedle when lacking water, has self-adhesion and low sensitization, can cover the soluble microneedle on the skin to be difficult to fall off, and enables the soluble microneedle to pass through the horny layer and reach the dermis layer, so that the effective component of the soluble microneedle can be efficiently and quickly absorbed by the skin.
Description
Technical Field
The invention belongs to the technical field of skin care products, and particularly relates to a hydrogel patch for soluble microneedles and a preparation method thereof.
Background
With the age, the skin inevitably becomes loose, and dry lines, fishtail lines, statute lines and the like are generated. Due to the barrier effect of the stratum corneum of the skin, the effective components such as hyaluronic acid in the common anti-wrinkle skin care products are difficult to absorb into the parts of the epidermis basal layer and the dermis layer, so as to play the anti-wrinkle effect. Although the traditional hyaluronic acid injection method can well directly inject hyaluronic acid under the skin, the requirements on skills of operators are high, pain is strong in the injection process, and adverse conditions such as local redness, swelling, blood stasis and pigmentation often occur.
Recently, the micro-needle beauty treatment is increasingly carried out, the micro-needle can pierce the skin to form a micro-channel on the horny layer, and the beauty active ingredients reach the deep layer of the skin along the micro-channel and diffuse into the dermis. Due to the elasticity of the skin and the tiny size of the microneedle, the depth of the microneedle entering the skin usually cannot reach the dermis, obvious pain cannot be caused, and the microneedle is a painless permeation promoting technology. The microneedle takes hyaluronic acid as a substrate, and hyaluronic acid is dissolved and retained in the skin under the action of body fluid after the microneedle penetrates into the skin of a human body, so that the microneedle not only has a beautifying effect, but also does not cause inflammatory reaction because hyaluronic acid is an endogenous substance of the human body. However, when the soluble microneedle is used, water is needed to be dissolved, and too much water can dissolve the soluble microneedle on the surface of the skin without entering the skin and cannot reach the dermis; if the moisture content is too small, the microneedle will be slowly dissolved, and the application will take a long time, and the effect will not be ideal.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides a preparation method of a hydrogel patch for soluble microneedles, aiming at solving the technical problems that the soluble microneedles need to be dissolved by water when in use, the soluble microneedles cannot enter the skin and are dissolved on the surface of the skin and cannot reach the dermis when the water content is too much, the microneedles are slowly dissolved when the water content is too little, the application time is long, and the effect is not ideal. The invention also provides the hydrogel patch for the soluble microneedle, which is prepared by the method.
The invention provides a preparation method of a hydrogel patch for soluble microneedles, which comprises the following specific technical scheme:
a method for preparing a hydrogel patch for dissolvable microneedles, comprising the steps of:
s1, uniformly mixing 2-3% of the cross-linked skeleton and 0.05-3.0% of the cross-linking agent, adding 10-50% of the humectant, and fully and uniformly stirring to obtain a phase A solution;
s2, adding 0.5-2% of tackifier into water, stirring, adding 0.01-5% of crosslinking regulator and 1-15% of water-soluble functional component, and stirring until the components are fully dissolved to obtain a B-phase solution;
s3, adding the phase B solution obtained in the step S2 into the phase A solution obtained in the step S1, and carrying out vacuum stirring to obtain a hydrogel paste;
s4, the hydrogel paste in step S3 is coated on a coater to obtain a hydrogel patch for dissolvable microneedles.
In certain embodiments, in step S1, the crosslinked backbone is sodium polyacrylate; the cross-linking agent is one or more of aluminum dihydroxyglycinate, aluminum chloride and sodium hydroxide.
In certain embodiments, in step S1, the humectant is one or more of glycerin, butylene glycol, propylene glycol, hexylene glycol, sorbitol, polyethylene glycol, sodium hyaluronate, ceramide.
In certain embodiments, in step S2, the viscosity increasing agent is one or more of sodium alginate, tragacanth, carbomer, methyl cellulose, ethyl cellulose, sodium carboxymethyl cellulose, polyvinylpyrrolidone, and polyethylene glycol.
In certain embodiments, in step S2, the crosslinking modifier is one or more of citric acid, tartaric acid, lactic acid, malic acid, EDTA, malic acid.
In some embodiments, in step S2, the water-soluble functional ingredient is one or more of niacinamide, phenethyl resorcinol, vitamin C, arbutin, tranexamic acid, collagen, and polypeptide.
In certain embodiments, in step S3, the stirring speed of the vacuum stirring is 50-120r/min, the stirring time is 5-15min, and the vacuum is pumped to-0.08 MPa while stirring.
In some embodiments, in step S4, the coated non-woven fabric is a lower layer, the pearlescent film is an upper layer, and the pearlescent film can be die-cut and packaged when the pearlescent film can be completely torn.
The invention also provides the hydrogel patch for the soluble microneedle, which is prepared by the method.
The invention has the following beneficial effects: the invention provides a hydrogel patch for soluble microneedles, which is used in cooperation with the soluble microneedles, can swell when meeting water due to the hydrophilic reticular polymer swelling body, can release the moisture of the soluble microneedles in the absence of water, has self-adhesion and low sensitization, can cover the soluble microneedles on the skin to be difficult to fall off, enables the soluble microneedles to penetrate through the horny layer and reach the dermis layer, enables effective components of the soluble microneedles to be efficiently and quickly absorbed by the skin, and ensures that the effects of moisturizing, fine line fading and dark eye circle fading of the microneedles are stably exerted.
Drawings
Fig. 1 is a flowchart of a method for preparing a hydrogel patch for dissolvable microneedles according to the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to specific embodiments and the accompanying drawings.
Example 1
The embodiment provides a preparation method of a hydrogel patch for soluble microneedles, and the specific technical scheme is as follows:
a method for preparing a hydrogel patch for dissolvable microneedles, comprising the steps of:
s1, uniformly mixing a cross-linked skeleton (sodium polyacrylate) of 2% and a cross-linking agent (aluminum dihydroxyglycinate) of 0.05%, adding a humectant (sodium hyaluronate) of 10%, and fully and uniformly stirring to obtain a phase A solution;
s2, adding 0.5% of tackifier (sodium alginate) into water, stirring, adding 0.01% of crosslinking regulator (citric acid) and 1-15% of water-soluble functional components (nicotinamide, phenethyl resorcinol, vitamin C, arbutin, tranexamic acid, collagen and polypeptide), and stirring to fully dissolve to obtain a B-phase solution;
s3, adding the phase B solution obtained in the step S2 into the phase A solution obtained in the step S1, stirring in vacuum at the stirring speed of 50r/min, vacuumizing to-0.08 MPa while stirring, and stirring for 15min to obtain a hydrogel paste;
and S4, coating the hydrogel paste obtained in the step S3 on a coating machine, wherein the non-woven fabric is a lower layer, the pearlized film is an upper layer, and die cutting and packaging can be carried out when the pearlized film can be completely torn, so that the hydrogel patch for the soluble microneedles is obtained.
The present example also provides a hydrogel patch for dissolvable microneedles prepared by the above method. The hydrogel patch obtained by the implementation has certain viscosity, low sensitization and proper moisture content, when the microneedle patch is used, the gel is covered and pasted on the skin, and the microneedle patch can be pasted for 2-4 hours, so that the microneedle patch can be almost completely absorbed by the skin, has good effects of removing wrinkles, freckles, acnes, eye bags and dark circles, and can play the greatest role.
Example 2
The embodiment provides a preparation method of a hydrogel patch for soluble microneedles, and the specific technical scheme is as follows:
a method for preparing a hydrogel patch for dissolvable microneedles, comprising the steps of:
s1, uniformly mixing 1.5% of sodium polyacrylate and 2.0% of cross-linking agent (aluminum dihydroxyglycinate, aluminum chloride and sodium hydroxide), adding 30% of humectant (glycerol, sodium hyaluronate and ceramide), and fully and uniformly stirring to obtain phase A solution;
s2, adding 1% of tackifier (sodium alginate, sodium carboxymethylcellulose, polyvinylpyrrolidone and polyethylene glycol) into water, stirring, adding 3% of crosslinking regulator (citric acid, EDTA and malic acid) and 10% of water-soluble functional component (nicotinamide, vitamin C, arbutin and collagen), and stirring to fully dissolve to obtain a B-phase solution;
s3, adding the phase B solution obtained in the step S2 into the phase A solution obtained in the step S1, stirring in vacuum at the stirring speed of 80r/min, vacuumizing to-0.08 MPa while stirring, and stirring for 10min to obtain a hydrogel paste;
and S4, coating the hydrogel paste obtained in the step S3 on a coating machine, wherein the non-woven fabric is a lower layer, the pearlized film is an upper layer, and die cutting and packaging can be carried out when the pearlized film can be completely torn, so that the hydrogel patch for the soluble microneedles is obtained.
The present example also provides a hydrogel patch for dissolvable microneedles prepared by the above method. The hydrogel patch obtained by the implementation has certain viscosity, low sensitization and proper moisture content, when the microneedle patch is used, the gel is covered and pasted on the skin, and the microneedle patch can be pasted for 2-4 hours, so that the microneedle patch can be almost completely absorbed by the skin, has good effects of removing wrinkles, freckles, acnes, eye bags and dark circles, and can play the greatest role.
Example 3
The embodiment provides a preparation method of a hydrogel patch for soluble microneedles, and the specific technical scheme is as follows:
a method for preparing a hydrogel patch for dissolvable microneedles, comprising the steps of:
s1, uniformly mixing 3% of sodium polyacrylate and 3.0% of cross-linking agent (in dihydroxy aluminum glycinate and sodium hydroxide), adding 30% of humectant (sorbitol, polyethylene glycol and sodium hyaluronate), and fully and uniformly stirring to obtain A-phase solution;
s2, adding 2% of tackifier (sodium alginate and polyethylene glycol) into water, stirring, adding 5% of crosslinking regulator (EDTA and malic acid) and 15% of water-soluble functional component (nicotinamide), and stirring until the components are fully dissolved to obtain a B-phase solution;
s3, adding the phase B solution obtained in the step S2 into the phase A solution obtained in the step S1, stirring in vacuum at the stirring speed of 120r/min, vacuumizing to-0.08 MPa while stirring, and stirring for 5min to obtain a hydrogel paste;
and S4, coating the hydrogel paste obtained in the step S3 on a coating machine, wherein the non-woven fabric is a lower layer, the pearlized film is an upper layer, and die cutting and packaging can be carried out when the pearlized film can be completely torn, so that the hydrogel patch for the soluble microneedles is obtained.
The present example also provides a hydrogel patch for dissolvable microneedles prepared by the above method. The hydrogel patch obtained by the implementation has certain viscosity, low sensitization and proper moisture content, when the microneedle patch is used, the gel is covered and pasted on the skin, and the microneedle patch can be pasted for 2-4 hours, so that the microneedle patch can be almost completely absorbed by the skin, has good effects of removing wrinkles, freckles, acnes, eye bags and dark circles, and can play the greatest role.
The above description is only for the purpose of illustrating preferred embodiments of the present invention and is not to be construed as limiting the invention, and the present invention is not limited to the above examples, and those skilled in the art should also be able to make various changes, modifications, additions or substitutions within the spirit and scope of the present invention.
Claims (9)
1. The preparation method of the hydrogel patch for the soluble microneedle is characterized by comprising the following steps of:
s1, uniformly mixing 2-3% of the cross-linked skeleton and 0.05-3.0% of the cross-linking agent, adding 10-50% of the humectant, and fully and uniformly stirring to obtain a phase A solution;
s2, adding 0.5-2% of tackifier into water, stirring, adding 0.01-5% of crosslinking regulator and 1-15% of water-soluble functional component, and stirring until the components are fully dissolved to obtain a B-phase solution;
s3, adding the phase B solution obtained in the step S2 into the phase A solution obtained in the step S1, and carrying out vacuum stirring to obtain a hydrogel paste;
s4, the hydrogel paste in step S3 is coated on a coater to obtain a hydrogel patch for dissolvable microneedles.
2. The method of preparing a hydrogel patch for dissolvable microneedles in claim 1, wherein in step S1, the cross-linked backbone is sodium polyacrylate; the cross-linking agent is one or more of aluminum dihydroxyglycinate, aluminum chloride and sodium hydroxide.
3. The method of preparing a hydrogel patch for dissolvable microneedles in claim 1, wherein in step S1, the humectant is one or more of glycerin, butylene glycol, propylene glycol, hexylene glycol, sorbitol, polyethylene glycol, sodium hyaluronate, ceramide.
4. The method of preparing a hydrogel patch for soluble microneedles in claim 1, wherein the viscosity increasing agent is one or more of sodium alginate, tragacanth, carbomer, methyl cellulose, ethyl cellulose, sodium carboxymethyl cellulose, polyvinylpyrrolidone, and polyethylene glycol in step S2.
5. The method of preparing a hydrogel patch for dissolvable microneedles in claim 1, wherein in step S2, the crosslinking modulating agent is one or more of citric acid, tartaric acid, lactic acid, malic acid, EDTA, malic acid.
6. The method of preparing a hydrogel patch for dissolvable microneedles in claim 1, wherein in step S2, the water-soluble functional ingredient is one or more of niacinamide, phenethyl resorcinol, vitamin C, arbutin, tranexamic acid, collagen, polypeptide.
7. The method of preparing a hydrogel patch for soluble microneedles in claim 1, wherein the stirring speed of the vacuum stirring is 50-120r/min, the stirring time is 5-15min, and the vacuum pumping is performed to-0.08 MPa while stirring in step S3.
8. The method of preparing a hydrogel patch for dissolvable microneedles in claim 1, wherein the non-woven fabric in the coating is a lower layer and the pearlescent film is an upper layer in step S4, and the die cutting and packaging can be performed when the pearlescent film can be completely torn.
9. The hydrogel patch for dissolvable microneedles, which is prepared according to the method for preparing the hydrogel patch for dissolvable microneedles of any one of claims 1 to 8.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112494799A (en) * | 2021-02-04 | 2021-03-16 | 山东元旭光电股份有限公司 | Hydrogel slide automatic feeding and mounting device |
| CN113813221A (en) * | 2021-10-29 | 2021-12-21 | 湖北省麦诗特生物科技有限公司 | Soluble beauty microneedle patch composition for removing wrinkles and resisting aging of skin and preparation method thereof |
| CN113893197A (en) * | 2021-10-29 | 2022-01-07 | 湖北省麦诗特生物科技有限公司 | Skin whitening and anti-saccharification soluble beautifying microneedle patch composition and preparation method thereof |
| CN113908092A (en) * | 2021-10-29 | 2022-01-11 | 湖北省麦诗特生物科技有限公司 | Skin acne removing and oil control soluble beautifying microneedle patch composition and preparation method thereof |
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| CN113893197B (en) * | 2021-10-29 | 2024-01-30 | 湖北省麦诗特生物科技有限公司 | Skin whitening and anti-saccharification soluble beautifying microneedle patch composition and preparation method thereof |
| CN114366091A (en) * | 2022-01-17 | 2022-04-19 | 礼诚(北京)国际生物医药科技有限公司 | Microneedle patch for continuously monitoring or detecting in-vivo analyte, preparation method thereof and related device |
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Application publication date: 20200804 |