CN104826228A - Biological paster for skin regeneration and maintenance - Google Patents
Biological paster for skin regeneration and maintenance Download PDFInfo
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- CN104826228A CN104826228A CN201510268656.6A CN201510268656A CN104826228A CN 104826228 A CN104826228 A CN 104826228A CN 201510268656 A CN201510268656 A CN 201510268656A CN 104826228 A CN104826228 A CN 104826228A
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- micropin
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- biological paste
- microneedle array
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Abstract
The invention relates to a biological paster for skin regeneration and maintenance. The biological paster has different release gradients and has the better skin regeneration and cosmetic effect. The biological paster is composed of two parts which are cooperated to be used. One part comprises a base and a plurality of micro needles located on the base. The other part comprises a back coating, namely a gel cold compress layer. A first soluble micro needle array and a second soluble micro needle array are arranged on the upper surface of the base and have different dissolution speeds. The first micro needle array comprises a plurality of first micro needles, and the second micro needle array comprises a plurality of second micro needles.
Description
Technical field
The application relates to a kind of biological paste, particularly, relates to a kind of biological paste for skin repair and maintenance with different release gradient.
Background of invention
How resisting human senescence, making skin improve elasticity, slow down aging is the eternal topic of beauty treatment fields.When human body occurs old and feeble, skin of face can form wrinkle and mottle.Drug cosmetics and surgery beauty treatment are two kinds of main intervention forms; but skin particularly horny layer has barrier action to Drug Percutaneous Absorption; during obstruction drug cosmetics, skin is to the absorption of medicine; surgery beauty treatment has that the suitability is wide, risk is high, complication and the shortcoming such as side effect is many, and drug cosmetics and surgery beauty treatment usually due to dosage control or can operate improper generation pain and spot.In recent years, a kind ofly to paste for the micropin of improving looks, or be referred to as biological paste and day by day used by users, this micropin has higher safety and nonirritant.This biological paste is drawn together substrate and is positioned at suprabasil multiple micropin, also comprise back of the body coating alternatively, described micropin applies the material of such as skin repair and beauty treatment, or directly the solid, shaped of these materials is made micropin itself, in use back of the body coating is affixed on microneedle substrate face and is absorbed by the body gradually by finger pressure micropin back of the body coating.
The skin of human body has three-layer weave: be positioned at outermost horny layer, living Epidermis's layer and be positioned at innermost skin corium.Cuticle thickness is about 30 ~ 50 microns, is made up of the horn cell of densification, and it is very low to the permeability of most medicine, is the major obstacle that these medicines are carried by percutaneous; Skin layer thickness is about 50 ~ 100 microns, containing competent cell and little nervous tissue of measuring, but does not have blood vessel; Be skin corium below epidermal area, it is the key component of skin, containing a large amount of living cells, nervous tissue and vascular tissue.Conventional subcutaneous injection needs professional to operate, and syringe needle external diameter is generally 0.4 ~ 3.4 millimeter, and syringe needle needs transdermal to be deep in muscle, can touch blood vessel and damage a large amount of nervous tissue, usually causing patient's bleeding and pain.And adopt microneedle array, the duct of a large amount of micron dimension size can be produced by pressing the mode executing pin instantaneously at keratodermatitis and epidermal area, thus significantly improve the permeability of medicine.Because micropin medicine-feeding part does not touch nervous tissue and blood vessel at body surface, therefore pain and bleeding can not be produced; In addition, micropin administration is adopted not need professional to operate, flexible and convenient to use, can interruption of the administration at any time, so be more easily easily accepted by the patient.In addition, the stratum corneum barrier of microneedle skin produces microchannel makes medicine infiltrate the capillary network of dermal layer of the skin by micropin hole, with blood circulation through treatment target position, quick and efficient absorption medicine or cosmetic material object can be reached, micropin stimulates skin corium simultaneously, percutaneous self-healing ability, promotes ossein hypertrophy, and micropin can improve the absorbance of medicine and reduce the waste of medicine.In addition, sharp because micropin is thin, paracentesis depth, only at horny layer and dermis, does not contact teleneuron, therefore reduces the degree of injury of body tissue.
Current micropin biological paste comprises multiple different form, mainly comprises solid microneedles, empty micropin, solubility micropin.Wherein, solid microneedles is formed by insoluble polymer, monocrystal silicon and metal in skin usually, and drug coat is at micropin outer surface; Empty micropin is that each micropin comprises a passage, and apply medicine by this passage target area on earth from substrate, empty micropin has advantage that is lasting, controllable drug delivery; Solubility micropin refers to that micropin itself is made up of medicine, and be pressed into by biological paste after on human body skin, micropin dissolves gradually, residual substrate layer need be peeled off from skin, have the advantages such as pain is little, easy to operate for last.
Paste specific to the biological micropin for skin repair and beauty treatment, it can be solid microneedles, and microneedle array surface application has skin repair and cosmetic material to thrust skin again, or after microneedle array thrusts skin, repaste deposited skin repair and cosmetic material.Biological micropin subsides for skin repair and beauty treatment can be solubility micropins, microneedle array itself is formed by material skin to reparation and cosmetic result, micropin is integrally formed, and each micropin shape is identical and comprise identical material, can not carry out a point gradient administration during use to skin.
Prior art is sufficient proof: hyaluronic acid has moisturizing, maintenance and Nutrition to skin, it can pin large quantity of moisture, skin is made to keep full high resilience, reduce wrinkle, also can mild dilation blood capillary, increase blood circulation, improve intermediate supersession, promote the absorption of skin-nourishing and the discharge of refuse, hyaluronic acid is again good Percutaneous absorption enhancer while moisturizing.The daltonian non-crosslinked hyaluronic acid in 30K ~ 4000000, preferably the micropin intensity made of 500 ~ 2000000 daltonian non-crosslinked hyaluronic acids is high, and absorption efficiency is high, soak time is lasting.
In one embodiment, micropin raw material is the molecular weight of different molecular weight is the hyaluronic mixing of the daltonian non-crosslinked in 30K ~ 3000000, preferably also be mixed with cross-linked-hyaluronic acid, cross-linked-hyaluronic acid can be natural cross-linked-hyaluronic acid, or with the hyaluronic acid that BDDE is crosslinked.Experiment proves, molecular weight is that the micropin intensity that 30K ~ 3000000 daltonian non-crosslinked hyaluronic acid is made is high, the hyaluronic acid of mixing different molecular weight not only improves micropin intensity further, and be easy in skin to dissolve, degradation speed is slow in skin, make cosmetic result better, more lasting.
More preferably, active component can be added in biological paste raw material: skin moisturizer, such as glycerol or filaggrin; Be beneficial to vigor and the nutrient substance of skin repair, as: stem cell, epidermal growth factor, vitamin C, vitamin A or vitamin E, Semen Castaneae stock solution, Testa oryzae stock solution, Rhizoma Dioscoreae stock solution etc.; Skin-whitening agents, as: hydroquinone, arbutin, kojic acid, hydroxyacetic acid or nicotiamide etc.
In a detailed description of the invention, micropin raw material is molecular weight is 30K ~ 3000000 daltonian non-crosslinked hyaluronic acid, natural cross-linked-hyaluronic acid, fat stem cell, epidermal growth factor, vitamin E, hydroquinone, Semen Castaneae stock solution, Testa oryzae stock solution, Rhizoma Dioscoreae stock solution, high-molecular gel, glycerol etc.
In another detailed description of the invention, the raw material forming gel adhered layer comprises Semen Castaneae stock solution, Testa oryzae stock solution, Rhizoma Dioscoreae stock solution, high-molecular gel, glycerol etc., contributes to having cold compress effect when being bonded on skin to skin.
Stem cell is the pluripotent cell that a class has self renewal, infinite copy and Multidirectional Differentiation ability, and medical circle is called " general-purpose cell ".Wherein, fat stem cell has extremely strong in-vitro multiplication ability, can to cell direction differentiation such as fat, bone, muscle, endothelium, islets of langerhans, nerves.Compared with other stem cell, the advantages such as fat stem cell has that biological characteristics is stable, source is sufficient, easily obtain and condition of in vitro culture is simple.Fat stem cell can secrete cytokines and somatomedin, play the function of senile cell of nutrition, reparation and replacement body injury, can also antioxidant be provided, scavenging activated oxygen, heat shock protein is to local, local toxicity material is eliminated, promotes biological cells and tissues reparation, in addition, fat stem cell can increase collagen secretion, engulf pigment removal mottle, improve skin elasticity, therefore fat stem cell has the effect of extraordinary crease-resistant, speckle dispelling.
Epidermal growth factor can promote that cytotrophy material is initiatively transported in cell from extracellular, increases intracellular nutrition.Promote skin corium emiocytosis rubber polymer fibril, make dermal tissue full, thus reduce and smooth away wrinkles.In addition, the propagation of epidermal growth factor to epidermis cell has stronger facilitation, and the accumulation such as residual of less pigment and dead cell, eliminate mottle and pigmentation, cutaneous manifestations is gone out in vain tender.Therefore, epidermal growth factor also has the effect smoothing away wrinkles and prevent mottle.
Semen Castaneae stock solution contains the nutrient substance such as saccharide, starch, protein, fat, vitamin B1 and B2, records according to Compendium of Material Medica: chestnut " smash loose, and honey is coated with face, makes the anxious wrinkle removing stricture of vagina of light ".
Testa oryzae stock solution helps skin, and to become water tender, bright, and life-time service can skin whitening, and being used for hair washing can maintaining hair while decontamination.According to modern study display, containing the abundant nutrient substance needed for skin such as vitamin A, B1, B2, C, E, aminoacid and nicotinic acid in Testa oryzae, energy blood circulation promoting, accelerates the metabolism of Skin Cell.In addition, in Testa oryzae, abundant cytotrophy composition and the bioactie agent of several functions is also contained, can delaying skin aging.Effectively can be improved the skin of speckle, wrinkle, coarse, skin sore or surface moisture deficiency.The effect also there is the function of moisturizing, effectively can prevent scaly dry skin, delaying skin is aging, preventing pigmentation; According to " Japanese agriculture news ", the comparative experiments result that morning sun university's young scientist Yamamoto great generation uses mouse to carry out shows, the effect that the ceramide glucoside check melanin extracted from Testa oryzae generates is 29%, slightly lower than 39% of the kojic acid with same effect.Yamamoto is said, compared with other material, ceramide glucoside is a kind of safer cosmetic material, because it is not containing the toxin attacking the cell manufacturing pigment, can also alleviate the injury of ultraviolet to skin simultaneously.So skin wet, fair and clear can be made.
Controlled-release coating preferably can the medical grade substance of bio-absorbable, its dissolution velocity is in skin slower than the raw-material dissolution velocity of above-mentioned micropin, such as adopt the silicon coating that the silicon particle of porous is formed, such as, or adopting can the polymer of bio-absorbable, poly-DL-lactide, polylactide-altogether-second lactide; Polylactide-altogether-polycaprolactone, poly-(L-lactide-altogether-1,3-PD carbonic ester), poly-1,3-PD carbonic ester and copolymer; Poly butyric ester and copolymer; Poly-hydroxyl valerate and copolymer; Poe and copolymer; Polyanhydride and copolymer; Poly-iminocarbonic ester and copolymer.
When using the biological paste of the application, first by the skin clean of target area, drying, then be entirely attached on human body skin after the back of the body coating in the biological paste of the application being affixed on microneedle substrate face, by finger pressure micropin back of the body coating, microneedle array is made to thrust human body skin, second microneedle array directly starts to dissolve, release effective ingredient and the first microneedle array applies controlled-release coating due to skin, through after a period of time, such as just start to dissolve, discharge effective ingredient after the second microneedle array dissolves completely, thus realize a point gradient administration.The biological paste of the application comprises the daltonian non-crosslinked hyaluronic acid in 30K ~ 4000000, and preferably the micropin intensity made of 500 ~ 2000000 daltonian non-crosslinked hyaluronic acids is high, and absorption efficiency is high, soak time is lasting; The mixing hyaluronic acid of different molecular weight or cross-linked-hyaluronic acid not only improve micropin intensity further, and be easy in skin to dissolve, degradation speed is slow in skin, make cosmetic result better, more lasting; Add stem cell, epidermal growth factor, Semen Castaneae stock solution, Testa oryzae stock solution, Rhizoma Dioscoreae stock solution, with hyaluronic acid synergism, can further improve that biological paste is crease-resistant, the effect of speckle dispelling.
Summary of the invention
The application provides a kind of biological paste for skin repair and maintenance with different release gradient, and it has better skin repair and cosmetic result.
Biological paste according to the application, comprises substrate, is positioned at solubility first microneedle array of upper surface of substrate, the second microneedle array and back of the body coating.First microneedle array has different dissolution velocities from the second microneedle array.First microneedle array comprises some first micropins, and the second microneedle array comprises some second micropins.
In one embodiment, the back of the body coating in biological paste can play cold compress effect can strengthen again biological paste and skin bonding force as adhered layer.
The arrangement of the first microneedle array, the second microneedle array can be arranged arbitrarily as required, such as between independent first micropin and the second micropin, equal interval is arranged, or first micropin, the arrangement all in column of the second micropin, each row first micropin and each row second micropin interval are arranged, or the first micropin, the second micropin lopping arrangement, each circle the first micropin and each circle second micropin interval are arranged.
First micropin comprises kernel and controlled-release coating, and the second micropin is integrally formed.
The kernel of the first micropin and the second micropin can be made up of same micropin raw material, raw material is the daltonian non-crosslinked hyaluronic acids in 30K ~ 4000000, preferably 500 ~ 2000000 daltonian non-crosslinked hyaluronic acids, or for PVA and hyaluronic mixture are to realize the percutaneous controlled-release of large hydrophilic molecular as albumen, polypeptide, DNA, RNA and other drug.
Accompanying drawing explanation
Fig. 1: the front view of the biological paste according to the application;
Fig. 2: the top view of the biological paste according to the application;
The zoomed-in view of the Fig. 3: the first micropin.
Detailed description of the invention
See accompanying drawing 1,2, the biological paste according to the application, comprises substrate 1, and is positioned at solubility first microneedle array A, the second microneedle array B of substrate 1 upper surface.Microneedle array A has different dissolution velocities from microneedle array B.Microneedle array A comprises some first micropin a, microneedle array B and comprises some second micropin b.In one embodiment, the back of the body coating of biological paste can play cold compress effect can strengthen again biological paste and skin bonding force as adhered layer.
The arrangement of microneedle array A, microneedle array B can be arranged arbitrarily as required, such as between independent first micropin and the second micropin, equal interval is arranged, or micropin a, micropin b arrangement all in column, each row micropin a and each row micropin b interval are arranged, or micropin a, micropin b lopping arrangement, each circle micropin a and each circle micropin b interval are arranged.
Relative to micropin b, micropin a skin also comprises one deck controlled-release coating 3, and that is micropin a comprises kernel 4 and controlled-release coating 3, as shown in Figure 3.
The kernel 4 of micropin a and micropin b can be made up of same micropin raw material, and raw material is hyaluronic acid, or for PVA and hyaluronic mixture are to realize the percutaneous controlled-release of large hydrophilic molecular as albumen, polypeptide, DNA, RNA and other drug.
More specifically, micropin raw material is molecular weight is the daltonian non-crosslinked hyaluronic acid in 30K ~ 3000000 or hyaluronic acid or the cross-linked-hyaluronic acid being mixed with different molecular weight, cross-linked-hyaluronic acid can be natural cross-linked-hyaluronic acid, or with the hyaluronic acid that BDDE is crosslinked.Experiment proves, molecular weight is that the micropin intensity that 30K ~ 3000000 daltonian non-crosslinked hyaluronic acid is made is high, the hyaluronic acid of mixing different molecular weight not only improves micropin intensity further, and be easy in skin to dissolve, degradation speed is slow in skin, make cosmetic result better, more lasting.
Active component can be added: skin moisturizer, such as glycerol or filaggrin in biological paste raw material; Be beneficial to vigor and the nutrient substance of skin repair, as: stem cell, epidermal growth factor, vitamin C, vitamin A or vitamin E, Semen Castaneae stock solution, Testa oryzae stock solution, Rhizoma Dioscoreae stock solution etc.; Skin-whitening agents, as: hydroquinone, arbutin, kojic acid, hydroxyacetic acid or nicotiamide etc.
In a detailed description of the invention, micropin raw material is molecular weight is 30K ~ 3000000 daltonian non-crosslinked hyaluronic acid, natural cross-linked-hyaluronic acid, and back of the body coating raw material is fat stem cell, epidermal growth factor, vitamin E, hydroquinone, Semen Castaneae stock solution, Testa oryzae stock solution, Rhizoma Dioscoreae stock solution, high-molecular gel, glycerol etc.
Controlled-release coating 3 preferably can the medical grade substance of bio-absorbable, its dissolution velocity is in skin slower than the raw-material dissolution velocity of above-mentioned micropin, such as adopt the silicon coating that the silicon particle of porous is formed, such as, or adopting can the polymer of bio-absorbable, poly-DL-lactide, polylactide-altogether-second lactide; Polylactide-altogether-polycaprolactone, poly-(L-lactide-altogether-1,3-PD carbonic ester), poly-1,3-PD carbonic ester and copolymer; Poly butyric ester and copolymer; Poly-hydroxyl valerate and copolymer; Poe and copolymer; Polyanhydride and copolymer; Poly-iminocarbonic ester and copolymer.
When using the biological paste of the application, first by the skin clean of target area, drying, then the back of the body coating in the biological paste of the application being affixed on microneedle substrate face makes microneedle array thrust human body skin by finger pressure micropin back of the body coating, microneedle array B directly start dissolve, release effective ingredient and microneedle array A due to skin coating controlled-release coating 3, through after a period of time, such as just start to dissolve, discharge effective ingredient after microneedle array B dissolves completely, thus realize a point gradient administration.
Claims (10)
1. there is the biological paste for skin repair and maintenance of different release gradient, comprise substrate, and be positioned at solubility first microneedle array, second microneedle array of upper surface of substrate; It is characterized in that:
First microneedle array has different dissolution velocities from the second microneedle array; Wherein the first microneedle array comprises some first micropins, and the second microneedle array comprises some second micropins;
Described substrate also comprises gel sticking layer, and it can play cold compress effect can strengthen again biological paste and skin bonding force as adhered layer.
2. the biological paste for skin repair and maintenance according to claim 1, wherein biological paste also comprise be coated in upper surface of substrate adhesive layer, it can strengthen the bonding force of biological paste and skin.
3. the biological paste for skin repair and maintenance according to claim 1, wherein between independent first micropin and the second micropin, equal interval is arranged, or the arrangement all in column of the first micropin, the second micropin, each row first micropin and each row second micropin interval are arranged, or the first micropin, the second micropin lopping arrangement, each circle the first micropin and each circle second micropin interval are arranged.
4. the biological paste for skin repair and maintenance according to claim 1, wherein the first micropin comprises kernel and controlled-release coating, and the second micropin is integrally formed.
5. the biological paste for skin repair and maintenance according to claim 4, wherein the kernel of the first micropin and the second micropin can be made up of same micropin raw material.
6. the biological paste for skin repair and maintenance according to claim 5, wherein micropin raw material is the daltonian non-crosslinked hyaluronic acids in 30K ~ 4000000.
7. the biological paste for skin repair and maintenance according to claim 6, wherein micropin raw material is 500 ~ 2000000 daltonian non-crosslinked hyaluronic acids.
8. the biological paste for skin repair and maintenance according to claim 7, wherein micropin raw material is the hyaluronic mixture of 500 ~ 2000000 daltonian non-crosslinked of different molecular weight.
9. the biological paste for skin repair and maintenance according to claim 8, wherein also comprises cross-linked-hyaluronic acid in micropin raw material.
10. the biological paste for skin repair and maintenance according to claim 9, wherein also comprise skin moisturizer, stem cell, epidermal growth factor, vitamin C in micropin raw material, VitAVitE, Semen Castaneae stock solution, Testa oryzae stock solution, Rhizoma Dioscoreae stock solution, hydroquinone, arbutin, kojic acid, one or more in hydroxyacetic acid or nicotiamide; The raw material of gel adhered layer comprise in Semen Castaneae stock solution, Testa oryzae stock solution, Rhizoma Dioscoreae stock solution, high-molecular gel, glycerol one or more.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510268656.6A CN104826228B (en) | 2015-05-25 | 2015-05-25 | For skin repair and the biological paste of maintenance |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510268656.6A CN104826228B (en) | 2015-05-25 | 2015-05-25 | For skin repair and the biological paste of maintenance |
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| CN104826228A true CN104826228A (en) | 2015-08-12 |
| CN104826228B CN104826228B (en) | 2017-12-29 |
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| CN108325068A (en) * | 2018-04-04 | 2018-07-27 | 陈彦彪 | A kind of auxotype solubility micropin and micropin slide glass |
| CN108607157A (en) * | 2018-04-18 | 2018-10-02 | 北京化工大学 | A kind of soluble crosslinking-non-crosslinked compound micropin of hyaluronic acid |
| CN109328086A (en) * | 2017-05-30 | 2019-02-12 | Ｎｉｓｓｈａ株式会社 | Microneedle patch and its package body |
| CN109876197A (en) * | 2019-04-09 | 2019-06-14 | 珠海天威飞马打印耗材有限公司 | A kind of 3D printing skin and preparation method thereof |
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| CN111107897A (en) * | 2017-09-19 | 2020-05-05 | 株式会社Lg生活健康 | Hyaluronic acid bulking agent using microneedle patch |
| CN112218675A (en) * | 2018-05-28 | 2021-01-12 | 工业化妆品实验室有限责任公司 | Microneedle patch for transdermal injection |
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| CN112218675A (en) * | 2018-05-28 | 2021-01-12 | 工业化妆品实验室有限责任公司 | Microneedle patch for transdermal injection |
| CN112218675B (en) * | 2018-05-28 | 2023-12-22 | 微针公司 | Microneedle patch for percutaneous injection |
| CN109876197A (en) * | 2019-04-09 | 2019-06-14 | 珠海天威飞马打印耗材有限公司 | A kind of 3D printing skin and preparation method thereof |
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