KR20200062097A - Micro-spicule, Mold for Producing the Same and Method for Producing the Same - Google Patents

Abstract

The present invention relates to a micro spicule, a mold for manufacturing the same, and a manufacturing method thereof. More specifically, the present invention relates to a micro spicule for making a skin care material or a drug absorbed into the skin, a plastic mold for manufacturing the same, and a manufacturing method thereof.

Description

Micro-spicule, Mold for Producing the Same and Method for Producing the Same}

The present invention relates to a micro-spicule, a mold for manufacturing the same, and a method for manufacturing the same. More specifically, the present invention relates to a micro spicule for absorbing a skin cosmetic material or drug into the skin, a plastic mold for manufacturing the same, and a method for manufacturing the same.

The method of applying an active ingredient such as a skin beauty ingredient or a drug to the skin or attaching a pack or patch containing the active ingredient to the skin to deliver it to the body is an advantage of continuous drug delivery, painless, and easy to use. There is this.

However, since the stratum corneum layer having a thickness of 10 μm to 60 μm at the outermost surface of the skin prevents penetration of foreign substances into the body, the absorption rate of the active ingredient in the body is very low. In particular, when the active ingredient is hydrophilic or has a large molecular weight, its absorption rate in the body is further lowered.

Therefore, an administration method using an injection has been used to effectively deliver the active ingredient. However, since the diameter of a conventional needle is in millimeters and its length is in centimeters, it stimulates a number of pain points present in the skin, thereby causing considerable pain to a subject when using the needle. In addition, since injections are generally available only in hospitals or specialized skin care institutions, there is a disadvantage that they cannot be easily used at home.

In order to solve the disadvantages according to the related art, micro-needles having a diameter of several tens of μm to hundreds of μm and a length of several tens of μm to several thousand μm have been developed. Since the microneedles form micropores in the stratum corneum of the skin, substances that are hydrophilic or have a high molecular weight through the micropores formed can be easily absorbed into the skin or transferred to the body through the skin.

In addition, the use of a conventional microneedle increases the skin absorption rate or the body delivery rate of substances that are well absorbed by simply applying to the skin. Moreover, the microneedle of short length does not penetrate into the dermis layer where the nerves are distributed, so there is no pain. Even if the long microneedle penetrates to the dermal layer, the number of stimulation points is small because the diameter is smaller and the length is shorter than that of the conventional needle, so the subject's pain is greatly reduced.

WO 02/47555 discloses a process for treating a subject's skin, including a head forming a convex head surface and pins protruding a predetermined distance from the head surface and spaced a predetermined distance from the head surface. Disclosed is a device, and a method for applying a skin care substance after forming a micro hole in the stratum corneum layer using the device.

In addition, United States Patent Registration No. 5,487,726 discloses a vaccine application system comprising the step of applying a vaccine to the skin and forming micropores in the stratum corneum of the skin using a device equipped with spikes on the skin to which the vaccine is applied, and have.

However, according to International Patent Publication No. WO 02/47555 and United States Patent Registration No. 5,487,726, the step of applying the skin to the drug and the step of forming the micropores in the stratum corneum layer are separately performed, which causes inconvenience to the subject.

United States Patent No. 6,603,998 discloses a method of delivering a skin beauty substance by coating the skin beauty substance on the surface of the microneedle electrode and applying it to the skin.

In addition, U.S. Patent No. 6,132,755 discloses a system in which a drug storage container with a micropin is applied to the skin, the micropin passes through the stratum corneum of the skin, and a drug is delivered to the skin through the micropin using a pump. have.

In addition, United States Patent Application Publication No. 2005/0251088 discloses a method of storing a drug in the pores of a porous needle, making a fine hole in the stratum corneum of the porous needle, and delivering a skin care substance stored in the pores of the needle.

In addition, United States Patent No. 3,964,482 discloses a drug delivery device that allows the protrusion to pass through the stratum corneum of the skin and the drug diffuses into the skin using the device with a protrusion connected to a drug storage container.

However, according to the registered patents 6,603,998, 6,132,755 and 3,964,482, and United States Patent Application Publication No. 2005/0251088, there is a disadvantage that a separate device is required to deliver a skin beauty substance.

Another way to make the skin care substance more easily pass through the stratum corneum is to use the exfoliating cosmetic product and then apply the skin beauty substance to the skin. Exfoliating cosmetics are mainly exfoliated physically using a scrubbing agent that can exfoliate. After using the exfoliating cosmetics, be sure to wash off the scrubbing agent and apply the skin care substance, including the skin care substance, to the skin.

In addition, if it gets into the eye during the use of the scrubbing agent, it is not easy to remove the scrubbing agent, it feels foreign, and the cornea may be damaged by rubbing the eye.

Korean Registered Patent No. 10-1206985 contains a sugar scrub in a non-aqueous cosmetic, which is excellent in moisturizing skin, promoting blood circulation, removing skin wastes and dead skin cells, and has good stability over time and excellent spreading properties. The composition is disclosed.

However, the sugar scrub of the Republic of Korea Patent No. 10-1206985 has a disadvantage that the scrub effect is not large due to the large angle formed by each surface and the blunt edges.

In order to overcome the above-mentioned disadvantages of the prior art, the present inventors can easily and effectively pass the skin beauty substance or drug through the stratum corneum by using a micro-spicule of a tetrahedron or polygonal pyramid shape containing a skin beauty substance or an active ingredient as a scrub particle. The present invention was completed in view of the fact that it can be made.

The basic object of the present invention is to provide a micro-spicule for absorbing a skin cosmetic substance or drug into the skin.

Another object of the present invention is to provide a mold for manufacturing micro spicules for absorbing a skin cosmetic material or drug into the skin in which a tetrahedral or polygonal pyramid shape is engraved.

Still another object of the present invention is a step of filling (i) a skin cosmetic material or a drug, a biocompatible material and a mixed solution of water into an engraved mold; (ii) drying the mixed solution to obtain a micro spicule; And (iii) separating the micro spicules from the engraved mold, to provide a micro spicule manufacturing method for absorbing a skin cosmetic material or drug into the skin.

The basic object of the present invention described above is achieved by providing a micro spicule for absorbing a skin cosmetic material or drug into the skin.

The term "micro-spicule" as used herein refers to a micro-structure in the form of a tetrahedron or polygonal pyramid (see FIG. 1). In addition, the polygonal pyramid refers to a polyhedron in which one side is a polygon (referred to as a base), and all other sides are formed of triangles that meet at the vertices.

In the present specification, each side of the micro spicule may be flat, uneven, or hollow. In addition, there may be a defect such as a part of the edge or a corner of the micro spicule is broken.

The micro spicule of the present invention may be a biocompatible material such as polysaccharide, polyvinyl alcohol, carboxyvinyl polymer, chitosan, hyaluronic acid, cellulose polymer or salt. The biocompatible material refers to a material that is harmless to the human body and can be dissolved, decomposed or swollen in body fluids or water.

A recess may be formed on one or more surfaces of the micro spicule, and the depth of the recess may be within 1/2 of the height of the micro spicule.

The micro spicule of the present invention further comprises a skin beauty substance or drug, so that the skin beauty substance or drug can be effectively absorbed into the skin.

As shown in Fig. 2, the skin beauty substance 2 contained in the micro spicule 1 is applied on the skin 10 and, when knocked or rubbed by hand, the vertices or corners of the polyhedron are fine on the keratin 11 Form a hole or remove some of the dead skin cells.

When the skin beauty substance passes through the microporous layer 13 or the thinned stratum corneum formed in the stratum corneum layer, which is the largest physical barrier among the skin tissues, the epidermis and dermis 12 layers rich in moisture and relatively low in cell density are said to Since the skin beauty substance diffuses relatively easily, the skin absorbance of the skin beauty substance increases.

In order for this to occur, the vertices or corners of the polyhedron must have a sharp angle, so a polyhedron with a hexahedron or more may not be suitable for this application.

In addition, if the micro spicule 1 is maintained in its shape without being dissolved, there is a inconvenience that the user needs to wash. Moreover, when the micro spicules are embedded in the stratum corneum, the micro spicules block most of the micropores, so that the skin absorbency of the skin care substance is less improved. Therefore, it is preferable that the micro spicule that effectively absorbs a skin beauty substance or drug into the skin easily dissolves, decomposes or swells in body fluids or water.

In the case where the skin care substance 2 is previously included in the micro spicule 1, the skin beauty substance should be composed of components that do not dissolve the micro spicule.

Since the thickness of the stratum corneum layer is 10 μm to 60 μm and the skin is elastic, in order to form micropores in the stratum corneum, the micro spicules are preferably tetrahedral or polygonal, and the base and height of the tetrahedron or polygonal pyramid, respectively. It is preferably 50 μm to 500 μm.

The skin cosmetic material that may be included in the micro spicule of the present invention may be an antioxidant, a growth factor, a wrinkle improving material, or a cell culture or culture medium.

The antioxidant may be vitamin C, and the growth factor may be epithelial cell growth factor (EGF) or fibroblast growth factor (FGF), and the cell culture or culture medium may be stem cell culture or culture medium. Can be.

In addition, the drug that may be included in the micro spicule of the present invention may be insulin or growth hormone.

The tetrahedron or polygonal-shaped micro spicule 1 may be used by being filled with a skin care substance 2 on a patch 20 that can be attached to the skin, as shown in FIG. 3. In this way, there is an advantage in that the micro channel is formed only in the stratum corneum of the site where the skin beauty substance is to be delivered, and the micro channel is not formed in the keratin of the finger or palm.

The tetrahedron or polygonal microscopic microscopic 1 can be used in combination with the skin beauty substance 2, as well as disclosed in United States Patent No. 6,132,755 or United States Patent Publication No. 2005/0251088, etc. It can also be delivered directly into the skin by directly filling the skin beauty ingredients or vaccines such as anti-aging, wrinkle improvement, skin tone improvement, or drugs such as vaccines, epidermal growth factors, growth hormones, and insulin.

Another object of the present invention described above is to provide a mold for manufacturing a micro spicule for absorbing a skin cosmetic material or drug into the skin in which a tetrahedral or polygonal pyramid shape is engraved. 5, a cross section of the mold of the present invention is shown.

The mold may be a plastic selected from polypropylene, polyethylene, polyacrylate or polycarbonate.

Another object of the present invention described above is (i) filling the intaglio mold with a mixed solution of a skin cosmetic material or drug, a biocompatible material and water; (ii) drying the mixed solution to obtain a micro spicule; And (iii) separating the micro spicules from the engraved mold, to provide a micro spicule manufacturing method for absorbing a skin cosmetic material or drug into the skin.

In one embodiment of the present invention, the tetrahedron or polygonal-shaped micro spicules 1, as shown in FIG. 5, a solution 31 containing a component (biocompatible material) constituting the micro spicules and Filling the engraved mold 32 with a mixed solution of water (FIG. 5-A), drying the mixed solution to obtain micro spicules (FIG. 5-B), and encapsulating the micro spicules in the mold. It can be prepared by a method comprising the step of separating from (Fig. 5-c).

In the method of the present invention, the skin cosmetic material may be selected from antioxidants, growth factors, wrinkle improving substances and cell cultures or culture media.

The antioxidant may be vitamin C, and the growth factor may be epithelial cell growth factor (EGF) or fibroblast growth factor (FGF), and the cell culture or culture medium may be stem cell culture or culture medium. It might be.

In addition, the drug that may be included in the micro spicule of the present invention may be insulin or growth hormone.

The biocompatible material may be selected from polysaccharides, polyvinyl alcohol, carboxyvinyl polymer, chitosan, hyaluronic acid, cellulose polymer or salt.

The mold has an intaglio or polygonal pyramid shape, and the incised tetrahedron or polygonal pyramid may have a base and a height of 50 μm to 500 μm, respectively.

In addition, the mold may be a plastic selected from polypropylene, polyethylene, polyacrylate or polycarbonate.

By using the micro spicule of the present invention, a large amount of skin beauty substances or drugs can be absorbed into the skin or delivered through the skin to the body more efficiently than in the prior art.

In addition, the micro spicule of the present invention has an efficient shape and has a simple structure, and thus can be manufactured very easily.

1 is a perspective view of a typical micro spicule according to the present invention.
2 is an application example of a micro spicule according to an embodiment of the present invention.
3 is an application example of a micro spicule according to an embodiment of the present invention.
5 is a flow chart for a method of manufacturing a micro spicule of the present invention.
6 is a photograph of a micro spicule (base = 380 μm, height = 300 μm) prepared in an embodiment of the present invention.
7 is a photograph of a micro spicule (base = 700 μm, height = 500 μm) prepared in an embodiment of the present invention.

Hereinafter, the present invention will be described in more detail with reference to the following examples or drawings. However, the description of the following examples or drawings is only intended to describe and describe specific embodiments of the present invention, and is not intended to limit or limit the scope of the present invention to the contents described therein.

Example. Preparation of microstructures

After exposing the pattern to the silicon wafer, bulk-etching was performed to fabricate a silicon embossed mold. After nickel-plating the silicon mold, hot-press was heated to 220° C. to melt polypropylene, and a pressure of 17 kg _f /cm ² was applied to engrave about 23,400 polygonal pyramids, resulting in the length of the base. An intaglio plastic mold having a size of 9 cm × 9 cm, each having a depth of 380 μm × 500 μm and 700 μm × 700 μm, was produced. A mixed solution of 2 g of hyaluronic acid, 4 g of water and 200 μg of skin beauty substance was applied to the depression of the engraved plastic mold. Thereafter, the plastic mold was dried at room temperature, and then the molded polygonal pyramid-shaped micro spicule was detached. The microstructure of the polygonal pyramid thus obtained is shown in the photographs of FIGS. 6 and 7.

Claims (2)

In a water-soluble micro spicule in the shape of a tetrahedron or polygonal pyramid used as a scrub particle for absorbing a skin cosmetic substance or drug into the skin,
It characterized in that the depression is formed on at least one surface of the water-soluble micro-spicule, the depth of the depression is within 1/2 of the height of the micro-spicule,
Characterized in that the base and height of the tetrahedron or polygonal pyramid are 105 μm or more and 500 μm or less, respectively,
Water-soluble micro spicule, characterized in that 80% by weight or more of the micro spicule is made of a hyaluronic acid.
A water-soluble micro spicule, characterized in that at least 85% by weight of the micro spicule of claim 1 is made of diluronic acid.

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