CN112386503A - Microneedle mask containing active peptides and preparation method thereof - Google Patents
Microneedle mask containing active peptides and preparation method thereof Download PDFInfo
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- CN112386503A CN112386503A CN201910756011.5A CN201910756011A CN112386503A CN 112386503 A CN112386503 A CN 112386503A CN 201910756011 A CN201910756011 A CN 201910756011A CN 112386503 A CN112386503 A CN 112386503A
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- microneedle
- hyaluronic acid
- mask
- hyaluronate
- stock solution
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/91—Injection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
Abstract
The invention discloses a micro-needle mask containing active peptides, which comprises a mask substrate, micro-needles and an essence liquid layer; the micro-needle is arranged on the mask substrate; the essence is arranged in the microneedle; the method is characterized in that: the microneedle is processed from a plurality of components, and comprises the following components in percentage by weight: 60 to 92 percent of hyaluronic acid or hyaluronate, 5 to 35 percent of firming material, 1 to 15 percent of water-soluble fatty alcohol and 0.5 to 5 percent of active peptide; the balance of water; the microneedles are uniformly distributed on the mask substrate, and the number of the microneedles per square centimeter is 180-250; the length of the material is 100-300 microns; the mask provided by the invention is a micro-needle mask which is simple to operate, safe and reliable, has high efficiency in whitening, wrinkle removing, rapid dissolution and rapid absorption into the body.
Description
Technical Field
The invention relates to the field of skin care products, in particular to a microneedle mask containing active peptides and a preparation method thereof.
Background
The peptide is small molecular protein, which is formed by connecting amino acids with a certain sequence through amido bonds, 2 amino acids are called as dycepin, 3 amino acids are called as tripper, and the like; in the skin care process, peptides play important roles, such as cell proliferation, cell migration, pigment formation, protein synthesis and regulation; with the further understanding of the microstructure and the care mechanism of the skin, the application of various peptides in skin care can promote the skin care functions of collagen generation, free radical oxidation resistance, inflammation diminishing and repair and the like.
Research shows that the skin care effect of the active peptide mainly passes through two ways: firstly, the transmission process of neurotransmitter is blocked, and the contraction of muscles is reduced through the signal regulation effect, so that the skin care effect is achieved; secondly, the synthesis of protein in the skin is promoted, so that the skin recovers elasticity and plump and becomes plump.
However, whether the active peptide can play a role or not is critical to the absorption of the skin, and the peptide needs to penetrate through the cell membrane of the stratum corneum and can enter the dermis so as to be absorbed by the skin; since our skin is a natural barrier against external aggressions, the peptide ingredients of cosmetics are blocked on the skin surface, so that the absorption amount of the peptide is limited, and the skin care requirement is difficult to meet.
Therefore, how to improve the permeability and utilization efficiency of peptides is becoming a new focus for the development of skin care products.
At present, the mask product is basically a system thickened or suspended by a single raw material, and the active ingredients are wrapped by forming a three-dimensional structure by a few technical methods so as to improve the permeability and the utilization rate of the mask product.
Whereas traditional microneedle transdermal delivery typically goes through two steps: firstly, microneedle equipment such as microneedle rollers are adopted to stimulate the face, and then the face is nursed by applying a nursing mask, the method has complicated steps, and active ingredients coated on the surface of the skin cannot fully permeate the skin, so that the efficiency of the skin absorbing essence is low, and the skin can not be nursed efficiently; further, if the microneedle device is inadvertently broken during use, the microneedle device may remain in the body and cause damage to the skin.
Disclosure of Invention
In order to overcome the defects, the invention provides the microneedle mask containing the active peptides, which can enable the active peptides to be better absorbed, avoid the damage to the skin and well improve the absorption rate of the essence; in addition, the preparation method of the micro-needle mask is also provided, and the method can promote effective fusion of all substances in the mask and improve the skin care capability of the mask.
In order to achieve the purpose, the invention provides the following technical scheme:
a microneedle facial mask containing active peptide comprises a facial mask substrate, microneedles, and an essence liquid layer; the micro-needle is arranged on the mask substrate; the essence is arranged in the microneedle; the method is characterized in that: the microneedle is processed from a plurality of components, and comprises the following components in percentage by weight: 60 to 92 percent of hyaluronic acid or hyaluronate, 5 to 35 percent of firming material, 1 to 15 percent of water-soluble fatty alcohol and 0.5 to 5 percent of active peptide; the balance being water.
The improvement is further that the microneedles are uniformly distributed on the mask substrate, and the number of the microneedles per square centimeter is 180-250; the length of the film is 100 to 300 μm.
In a further improvement, the active peptide is one or a mixture of more of ceruloplasmin, acetyl hexapeptide, acetyl glutamyl heptapeptide, acetyl octapeptide, palmitoyl hexapeptide, palmitoyl oligopeptide, palmitoyl tripeptide and palmitoyl pentapeptide.
In a further improvement, the hard coating material is one or a mixture of polyvinyl pyrrolidone (PVP) and derivatives thereof, polyvinyl alcohol (PVA) and derivatives thereof, trehalose and glucan.
In a further improvement, the water-soluble fatty alcohol is one or a mixture of glycerol, propylene glycol, butanediol and ethylhexyl glycerin.
In a further improvement, the hyaluronic acid or hyaluronate salt comprises high molecular weight hyaluronic acid or hyaluronate salt, low molecular weight hyaluronic acid or hyaluronate salt; wherein the molecular weight of hyaluronic acid or hyaluronate with large molecular weight is 1500 kDa less than 2000 kDa; the molecular weight of hyaluronic acid or hyaluronate with small molecular weight is less than 6kDa and less than 150 kDa.
The preparation method of the microneedle face mask comprises the following steps:
the method comprises the following steps of firstly, preparing a microneedle stock solution:
1. taking a proper amount of hyaluronic acid or hyaluronate, adding a proper amount of water, stirring, and fully hydrolyzing the hyaluronic acid or hyaluronate to obtain hyaluronic acid or hyaluronate dissolved solution;
2. adding appropriate amount of active peptide, water soluble fatty alcohol, and film-hardening material into water, stirring, and mixing the raw materials to obtain active peptide mixed solution;
3. heating the active peptide mixed solution in the step (2), adding the active peptide mixed solution into the hyaluronic acid or hyaluronate dissolved solution in the step (1) when the temperature is increased to 30-50 ℃, and stirring to fully mix the active peptide mixed solution with the hyaluronic acid or hyaluronate dissolved solution to obtain an auxiliary stock solution;
4. and (4) cooling the auxiliary stock solution in the step (3), adding corresponding functional components after the temperature is reduced to room temperature, uniformly stirring, fully sterilizing and standing for a period of time to obtain the microneedle stock solution.
Step two, preparing the microneedle patch, which comprises the following specific processes:
1. injecting the microneedle stock solution into a PDMS microneedle mould by using a spin coater, covering a layer of firm film material on the surface of the microneedle stock solution, and then drying the microneedle stock solution by air shower at room temperature;
2. and after drying is finished, stripping the mould to obtain the microneedle patch.
Step three, preparing the microneedle face mask, which comprises the following specific steps:
uniformly distributing the microneedle patches on the mask substrate, and adding essence into the microneedle patches to obtain a complete microneedle mask.
Further improved, in the step one, the functional components are material components with the functions of whitening, removing freckles, replenishing water, moisturizing, compacting and tendering skin.
In a further improvement, in the first step, the total amount of hyaluronic acid or hyaluronate, water-soluble fatty alcohol, a firming material and an active peptide in the microneedle stock solution accounts for 20% -50% of the total amount of the microneedle patch stock solution.
Compared with the prior art, the invention has the beneficial effects that: the hyaluronic acid microneedle can penetrate through the horny layer on the skin and directly reach the inside of the skin to be quickly dissolved, the hyaluronic acid microneedle can be dissolved below the epidermis layer within 10 minutes and release active ingredients, the absorption time of microneedle display can be greatly shortened to effectively nurse the skin, the using method is simpler, the operation is simple and convenient, the hyaluronic acid microneedle is safe and reliable, and the operation of a special beauty shop or trained operators is not needed; saving nursing time and cost. When the active ingredients are contained at the end of the micro-needle point to be integrated, the active ingredients cannot fall off when the micro-needle penetrates into the skin, and high-price active ingredients can be effectively utilized; the micro-needle covering degree on the facial mask is high, so that the face of a user can be comprehensively covered by the micro-needle, and sufficient and effective nursing is achieved.
Detailed Description
The present invention will be further described with reference to the following examples.
A microneedle facial mask containing active peptide comprises a facial mask substrate, microneedles, and an essence liquid layer; the micro-needle is arranged on the mask substrate; the essence is arranged in the microneedle; the method is characterized in that: the microneedle is processed from a plurality of components, and comprises the following components in percentage by weight: 60 to 92 percent of hyaluronic acid or hyaluronate, 5 to 35 percent of firming material, 1 to 15 percent of water-soluble fatty alcohol and 0.5 to 5 percent of active peptide; the balance being water.
Further, the microneedles are uniformly distributed on the mask substrate, and the number of the microneedles per square centimeter is 180-250; the length of the film is 100 to 300 μm.
Further, the active peptide is one or a mixture of more of ceruloplasmin, acetyl hexapeptide, acetyl glutamyl heptapeptide, acetyl octapeptide, palmitoyl hexapeptide, palmitoyl oligopeptide, palmitoyl tripeptide and palmitoyl pentapeptide.
Further, the hard film material is one or a mixture of polyvinyl pyrrolidone (PVP) and derivatives thereof, polyvinyl alcohol (PVA) and derivatives thereof, trehalose and glucan.
Further, the water-soluble fatty alcohol is one or a mixture of glycerol, propylene glycol, butanediol and ethylhexyl glycerin.
Further, the hyaluronic acid or the hyaluronate salt comprises high molecular weight hyaluronic acid or hyaluronate salt, and low molecular weight hyaluronic acid or hyaluronate salt; wherein the molecular weight of hyaluronic acid or hyaluronate with large molecular weight is 1500 kDa less than 2000 kDa; the molecular weight of hyaluronic acid or hyaluronate with small molecular weight is less than 6kDa and less than 150 kDa.
The preparation method of the microneedle face mask comprises the following steps:
the method comprises the following steps of firstly, preparing a microneedle stock solution:
1. taking a proper amount of hyaluronic acid or hyaluronate, adding a proper amount of water, stirring, and fully hydrolyzing the hyaluronic acid or hyaluronate to obtain hyaluronic acid or hyaluronate dissolved solution;
2. adding appropriate amount of active peptide, water soluble fatty alcohol, and film-hardening material into water, stirring, and mixing the raw materials to obtain active peptide mixed solution;
3. heating the active peptide mixed solution in the step (2), adding the active peptide mixed solution into the hyaluronic acid or hyaluronate dissolved solution in the step (1) when the temperature is increased to 30-50 ℃, and stirring to fully mix the active peptide mixed solution with the hyaluronic acid or hyaluronate dissolved solution to obtain an auxiliary stock solution;
4. and (4) cooling the auxiliary stock solution in the step (3), adding corresponding functional components after the temperature is reduced to room temperature, uniformly stirring, fully sterilizing and standing for a period of time to obtain the microneedle stock solution.
Step two, preparing the microneedle patch, which comprises the following specific processes:
1. injecting the microneedle stock solution into a PDMS microneedle mould by using a spin coater, covering a layer of firm film material on the surface of the microneedle stock solution, and then drying the microneedle stock solution by air shower at room temperature;
2. and after drying is finished, stripping the mould to obtain the microneedle patch.
Step three, preparing the microneedle face mask, which comprises the following specific steps:
uniformly distributing the microneedle patches on the mask substrate, and adding essence into the microneedle patches to obtain a complete microneedle mask.
Further improved, in the step one, the functional components are material components with the functions of whitening, removing freckles, replenishing water, moisturizing, compacting and tendering skin.
In a further improvement, in the first step, the total amount of hyaluronic acid or hyaluronate, water-soluble fatty alcohol, firming material and active peptide in the microneedle stock solution accounts for 20% -50% of the total amount of the cosmetic microneedle patch stock solution.
The first embodiment is as follows: preparation of blue copper peptide microneedle mask
The required raw materials are as follows: 70% of hyaluronic acid, 20% of trehalose, 5% of ethylhexyl glycerol, 3% of ceruloplasmin and the balance of water.
The detailed preparation process is as follows:
the method comprises the following steps of firstly, preparing a microneedle stock solution:
1. taking 70% of hyaluronic acid, adding a proper amount of water, and stirring to fully hydrolyze the hyaluronic acid to obtain a hyaluronic acid solution;
2. adding 3% of bluecopper peptides, 5% of ethylhexyl glycerol and 20% of trehalose into water, and stirring to fully mix the raw materials to obtain a bluecopper peptide mixed solution;
3. heating the blue copper peptide mixed solution in the step (2), adding the blue copper peptide mixed solution into the hyaluronic acid solution in the step (1) when the temperature is raised to 30 ℃, and stirring to fully mix the blue copper peptide mixed solution and the hyaluronic acid solution to obtain an auxiliary stock solution;
4. and (4) cooling the auxiliary stock solution in the step (3), adding a material with a whitening functional component after the temperature is reduced to room temperature, uniformly stirring, fully sterilizing and standing for a period of time to obtain the microneedle stock solution.
Step two, preparing the microneedle patch, which comprises the following specific processes:
1. injecting the microneedle stock solution into a PDMS microneedle mould by using a spin coater, covering a layer of 20% trehalose on the surface of the microneedle stock solution, and then drying the microneedle stock solution by air shower at room temperature;
2. and after drying is finished, stripping the mould to obtain the microneedle patch.
Step three, preparing the microneedle face mask, which comprises the following specific steps:
uniformly distributing the microneedle patches on the mask substrate, and adding essence into the microneedle patches to obtain a complete microneedle mask.
In this example, the number of micro needles per square centimeter of mask substrate was 200; the length of which is 100 microns.
The second embodiment is as follows: preparation of palmitoyl pentapeptide microneedle mask
The required raw materials are as follows: 60% of hyaluronic acid, 33% of trehalose, 10% of ethylhexyl glycerol, 2% of palmitoyl pentapeptide and the balance of water;
the detailed preparation process is as follows:
the method comprises the following steps of firstly, preparing a microneedle stock solution:
1. taking 60% hyaluronic acid, adding a proper amount of water, and stirring to fully hydrolyze the hyaluronic acid to obtain a hyaluronic acid solution;
2. adding 2% of palmitoyl pentapeptide, 10% of ethylhexyl glycerol and 33% of trehalose into water, and stirring to fully mix the raw materials to obtain a palmitoyl pentapeptide mixed solution;
3. heating the mixed solution of the palmitoyl pentapeptide in the step (2), adding the mixed solution of the palmitoyl pentapeptide into the hyaluronic acid solution in the step (1) when the temperature is raised to 30 ℃, and stirring to fully mix the mixed solution of the palmitoyl pentapeptide and the hyaluronic acid solution to obtain an auxiliary stock solution;
4. cooling the auxiliary stock solution in the step (3), adding a material with the freckle removing functional component after the temperature is reduced to room temperature, uniformly stirring, fully sterilizing and standing for a period of time to obtain a microneedle stock solution;
step two, preparing the microneedle patch, which comprises the following specific processes:
1. injecting the microneedle stock solution into a PDMS microneedle mould by using a spin coater, covering a layer of trehalose with the concentration of 33% on the surface of the microneedle stock solution, and then drying the microneedle stock solution by air shower at room temperature;
2. after drying is finished, stripping the mould to obtain the microneedle patch;
step three, preparing the microneedle face mask, which comprises the following specific steps:
uniformly distributing the microneedle patches on a mask substrate, and adding essence into the microneedle patches to obtain a complete microneedle mask;
in this example, the number of micro needles per square centimeter of mask substrate was 200; the length of which is 100 microns.
The use effect is as follows: when the facial mask is applied to the skin, the micro needles penetrate into the stratum corneum, the needle points of the hyaluronic acid are dissolved and retained in the skin, the active peptide molecules contained in the micro needles are released in the skin and are metabolized and absorbed, the dissolved hyaluronic acid has an anti-wrinkle effect under the skin, and the active peptide molecules dissolved in the needle bodies are diffused into the skin, so that the effects of whitening and removing wrinkles are effectively achieved, essence can be efficiently absorbed, and the effect of caring the skin is achieved.
The hyaluronic acid microneedle can penetrate through the horny layer on the skin and directly reach the inside of the skin to be quickly dissolved, the hyaluronic acid microneedle can be dissolved below the epidermis layer within 10 minutes and release active ingredients, the absorption time of microneedle display can be greatly shortened to effectively nurse the skin, the using method is simpler, the operation is simple and convenient, the hyaluronic acid microneedle is safe and reliable, and the operation of a special beauty shop or trained operators is not needed; saving nursing time and cost.
When the active ingredients are contained at the end of the micro-needle point to be integrated, the active ingredients cannot fall off when the micro-needle penetrates into the skin, and high-price active ingredients can be effectively utilized; the micro-needle covering degree on the facial mask is high, so that the face of a user can be comprehensively covered by the micro-needle, and sufficient and effective nursing is achieved.
The mask provided by the invention is a micro-needle mask which is simple to operate, safe and reliable, has high efficiency in whitening, wrinkle removing, rapid dissolution and rapid absorption into the body.
The present invention is not limited to the above-described embodiments, and those skilled in the art will be able to make various modifications without creative efforts from the above-described conception, and fall within the scope of the present invention.
Claims (9)
1. A microneedle facial mask containing active peptide comprises a facial mask substrate, microneedles, and an essence liquid layer; the micro-needle is arranged on the mask substrate; the essence is arranged in the microneedle; the method is characterized in that: the microneedle is processed from a plurality of components, and comprises the following components in percentage by weight: 60 to 92 percent of hyaluronic acid or hyaluronate, 5 to 35 percent of firming material, 1 to 15 percent of water-soluble fatty alcohol and 0.5 to 5 percent of active peptide; the balance being water.
2. The microneedle mask containing active peptides according to claim 1, wherein: the microneedles are uniformly distributed on the mask substrate, and the number of the microneedles per square centimeter is 180-250; the length of the film is 100 to 300 μm.
3. The microneedle mask containing active peptides according to claim 1, wherein: the active peptide is one or more of blue copper peptide, acetyl hexapeptide, acetyl glutamyl heptapeptide, acetyl octapeptide, palmitoyl hexapeptide, palmitoyl oligopeptide, palmitoyl tripeptide and palmitoyl pentapeptide.
4. The microneedle mask containing active peptides according to claim 1, wherein: the hard film material is one or a mixture of polyvinyl pyrrolidone (PVP) and derivatives thereof, polyvinyl alcohol (PVA) and derivatives thereof, trehalose and glucan.
5. The microneedle mask containing active peptides according to claim 1, wherein: the water-soluble fatty alcohol is one or more of glycerol, propylene glycol, butanediol and ethylhexyl glycerin.
6. The microneedle mask containing active peptides according to claim 1, wherein: the hyaluronic acid or the hyaluronate salt comprises high molecular weight hyaluronic acid or hyaluronate salt, and low molecular weight hyaluronic acid or hyaluronate salt; wherein the molecular weight of hyaluronic acid or hyaluronate with large molecular weight is 1500 kDa less than 2000 kDa; the molecular weight of hyaluronic acid or hyaluronate with small molecular weight is less than 6kDa and less than 150 kDa.
7. A method of microneedle mask according to any one of claims 1-6, comprising the steps of:
the method comprises the following steps of firstly, preparing a microneedle stock solution:
1. taking a proper amount of hyaluronic acid or hyaluronate, adding a proper amount of water, stirring, and fully hydrolyzing the hyaluronic acid or hyaluronate to obtain hyaluronic acid or hyaluronate dissolved solution;
2. adding appropriate amount of active peptide, water soluble fatty alcohol, and film-hardening material into water, stirring, and mixing the raw materials to obtain active peptide mixed solution;
3. heating the active peptide mixed solution in the step (2), adding the active peptide mixed solution into the hyaluronic acid or hyaluronate dissolved solution in the step (1) when the temperature is increased to 30-50 ℃, and stirring to fully mix the active peptide mixed solution with the hyaluronic acid or hyaluronate dissolved solution to obtain an auxiliary stock solution;
4. cooling the auxiliary stock solution in the step (3), adding corresponding functional components after the temperature is reduced to room temperature, uniformly stirring, fully sterilizing and standing for a period of time to obtain a microneedle stock solution;
step two, preparing the microneedle patch, which comprises the following specific processes:
1. injecting the microneedle stock solution into a PDMS microneedle mould by using a spin coater, covering a layer of firm film material on the surface of the microneedle stock solution, and then drying the microneedle stock solution by air shower at room temperature;
2. after drying is finished, stripping the mould to obtain the microneedle patch;
step three, preparing the microneedle face mask, which comprises the following specific steps:
uniformly distributing the microneedle patches on the mask substrate, and adding essence into the microneedle patches to obtain a complete microneedle mask.
8. A method of preparing a microneedle mask according to claim 7, wherein: the functional components are material components with the effects of whitening, removing freckles, moisturizing, compacting and tendering skin.
9. A method of preparing a microneedle mask according to claim 7, wherein: in the first step, the total amount of hyaluronic acid or hyaluronate, water-soluble fatty alcohol, a firming material and active peptide in the microneedle stock solution accounts for 20-50% of the total amount of the microneedle patch stock solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910756011.5A CN112386503A (en) | 2019-08-16 | 2019-08-16 | Microneedle mask containing active peptides and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910756011.5A CN112386503A (en) | 2019-08-16 | 2019-08-16 | Microneedle mask containing active peptides and preparation method thereof |
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| CN112386503A true CN112386503A (en) | 2021-02-23 |
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| CN201910756011.5A Pending CN112386503A (en) | 2019-08-16 | 2019-08-16 | Microneedle mask containing active peptides and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114983857A (en) * | 2022-05-25 | 2022-09-02 | 杭州铂赛生物科技有限公司 | Preparation method and application of pacific codfish skin gelatin peptide microneedle |
| CN115998638A (en) * | 2022-10-21 | 2023-04-25 | 沈阳药科大学 | Hydrogel patch of integrated microneedle and preparation method thereof |
| WO2023200874A1 (en) * | 2022-04-13 | 2023-10-19 | ALASTIN Skincare, Inc. | Combination of octapeptide and high molecular weight hyaluronic acid for topical application |
-
2019
- 2019-08-16 CN CN201910756011.5A patent/CN112386503A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023200874A1 (en) * | 2022-04-13 | 2023-10-19 | ALASTIN Skincare, Inc. | Combination of octapeptide and high molecular weight hyaluronic acid for topical application |
| CN114983857A (en) * | 2022-05-25 | 2022-09-02 | 杭州铂赛生物科技有限公司 | Preparation method and application of pacific codfish skin gelatin peptide microneedle |
| CN114983857B (en) * | 2022-05-25 | 2023-09-01 | 杭州铂赛生物科技有限公司 | Preparation method and application of Pacific cod skin gelatin peptide microneedle |
| CN115998638A (en) * | 2022-10-21 | 2023-04-25 | 沈阳药科大学 | Hydrogel patch of integrated microneedle and preparation method thereof |
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