CN113905787A - Mettl3抑制化合物 - Google Patents

Mettl3抑制化合物 Download PDF

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Publication number
CN113905787A
CN113905787A CN202080040641.3A CN202080040641A CN113905787A CN 113905787 A CN113905787 A CN 113905787A CN 202080040641 A CN202080040641 A CN 202080040641A CN 113905787 A CN113905787 A CN 113905787A
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CN
China
Prior art keywords
methyl
pyridin
imidazo
carboxamide
oxo
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Pending
Application number
CN202080040641.3A
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English (en)
Chinese (zh)
Inventor
韦斯利·彼得·布莱克比
大卫·詹姆斯·哈迪克
伊丽莎白·简·托马斯
弗雷德里克·亚瑟·布鲁克菲尔德
克里斯蒂安·布伯特
乔恩·谢泼德
马克·彼得·里吉尔
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Storm Treatment Co ltd
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Storm Treatment Co ltd
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Filing date
Publication date
Priority claimed from GBGB1904848.7A external-priority patent/GB201904848D0/en
Priority claimed from GBGB1912603.6A external-priority patent/GB201912603D0/en
Priority claimed from GBGB1919095.8A external-priority patent/GB201919095D0/en
Application filed by Storm Treatment Co ltd filed Critical Storm Treatment Co ltd
Publication of CN113905787A publication Critical patent/CN113905787A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN202080040641.3A 2019-04-05 2020-04-03 Mettl3抑制化合物 Pending CN113905787A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB1904848.7 2019-04-05
GBGB1904848.7A GB201904848D0 (en) 2019-04-05 2019-04-05 Inhibitory compounds
GBGB1912603.6A GB201912603D0 (en) 2019-09-02 2019-09-02 Inhibitory compounds
GB1912603.6 2019-09-02
GB1919095.8 2019-12-20
GBGB1919095.8A GB201919095D0 (en) 2019-12-20 2019-12-20 Inhibitory compounds
PCT/GB2020/050898 WO2020201773A1 (en) 2019-04-05 2020-04-03 Mettl3 inhibitory compounds

Publications (1)

Publication Number Publication Date
CN113905787A true CN113905787A (zh) 2022-01-07

Family

ID=70285722

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080040641.3A Pending CN113905787A (zh) 2019-04-05 2020-04-03 Mettl3抑制化合物

Country Status (5)

Country Link
US (2) US12358915B2 (https=)
EP (1) EP3946618A1 (https=)
JP (1) JP7762957B2 (https=)
CN (1) CN113905787A (https=)
WO (1) WO2020201773A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023151697A1 (zh) * 2022-02-11 2023-08-17 四川海思科制药有限公司 一种mettl3抑制剂及组合物及其在医药上的应用
WO2023217109A1 (zh) * 2022-05-13 2023-11-16 中国科学院广州生物医药与健康研究院 m6A RNA甲基化酶抑制剂与免疫检查点抑制剂联合治疗肿瘤
WO2024056099A1 (zh) * 2022-09-16 2024-03-21 北京华益健康药物研究中心 Mettl3抑制剂化合物及其药物组合物和应用

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WO2018165520A1 (en) 2017-03-10 2018-09-13 Vps-3, Inc. Metalloenzyme inhibitor compounds
MX2020003242A (es) 2017-09-22 2020-09-18 Jubilant Epipad LLC Compuestos heterociclicos como inhibidores de pad.
AU2018352142B2 (en) 2017-10-18 2022-08-25 Jubilant Epipad LLC Imidazo-pyridine compounds as PAD inhibitors
KR20200085836A (ko) 2017-11-06 2020-07-15 주빌런트 프로델 엘엘씨 Pd1/pd-l1 활성화 억제제로서의 피리미딘 유도체
BR112020010322A2 (pt) 2017-11-24 2020-11-17 Jubilant Episcribe Llc composto da fórmula i; composto da fórmula ia; composto da fórmula ib; processo de preparação de compostos da fórmula i; composição farmacêutica; método para o tratamento e/ou prevenção de várias doenças; uso dos compostos; método para o tratamento de câncer; e método para o tratamento e/ou prevenção de uma afecção mediada por prmt5 ou um distúrbio proliferativo ou câncer
SG11202008950PA (en) 2018-03-13 2020-10-29 Jubilant Prodel LLC Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation
JP7640458B2 (ja) 2018-10-05 2025-03-05 アンナプルナ バイオ インコーポレイテッド Ａｐｊ受容体活性に関連する状態を処置するための化合物および組成物
AU2020321955A1 (en) 2019-07-30 2022-03-17 Eikonizo Therapapeutics, Inc. HDAC6 inhibitors and uses thereof
IL293340A (en) 2019-12-02 2022-07-01 Storm Therapeutics Ltd Polyheterocyclic compounds as mettl3 inhibitors
US20230391770A1 (en) * 2020-10-06 2023-12-07 Storm Therapeutics Limited Mettl3 inhibitory compounds
US11944608B2 (en) * 2020-10-26 2024-04-02 New York University Targeting RNA viruses using inhibitors of METTL3
WO2022243333A1 (en) * 2021-05-17 2022-11-24 Universität Zürich N6-adenosine-methyltransferase inhibitors in cancer treatment
GB202107907D0 (en) * 2021-06-02 2021-07-14 Storm Therapeutics Ltd Combination therapies
GB202107905D0 (en) * 2021-06-02 2021-07-14 Storm Therapeutics Ltd Processes for the preparation of inhibitory compounds
CN116514805A (zh) * 2021-12-10 2023-08-01 成都先导药物开发股份有限公司 Mettl3抑制剂化合物
IL316201A (en) 2022-04-08 2024-12-01 Eikonizo Therapeutics Inc Oxadiazole HDAC6 inhibitors and their uses
CN114869891A (zh) * 2022-04-28 2022-08-09 复旦大学附属中山医院 Mettl3抑制剂在制备治疗肝癌药物中的应用
WO2024107763A1 (en) * 2022-11-16 2024-05-23 University Of Zurich N6-adenosine-methyltransferase protacs and methods of use thereof
GB202218672D0 (en) 2022-12-12 2023-01-25 Storm Therapeutics Ltd Inhibitory compounds
WO2024153775A1 (en) 2023-01-20 2024-07-25 Epics Therapeutics Piperidine derivatives as mettl3 inhibitors
WO2024200835A1 (en) 2023-03-30 2024-10-03 Novalix Novel mettl3 inhibitors and use thereof in therapy
GB202316683D0 (en) * 2023-10-31 2023-12-13 Storm Therapeutics Ltd Inhibitory compounds
WO2025237957A1 (en) 2024-05-14 2025-11-20 Institut Curie Composition for treatment of estrogen-dependent cancer comprising a mettl-3 inhibitor and a topoisomerase-1 inhibitor
CN121735955A (zh) * 2024-09-25 2026-03-27 中国科学院上海药物研究所 稠合双环类化合物及其制备方法、组合物和应用

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WO2007095588A1 (en) * 2006-02-14 2007-08-23 Novartis Ag Pi-3 kinase inhibitors and methods of their use
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023151697A1 (zh) * 2022-02-11 2023-08-17 四川海思科制药有限公司 一种mettl3抑制剂及组合物及其在医药上的应用
WO2023217109A1 (zh) * 2022-05-13 2023-11-16 中国科学院广州生物医药与健康研究院 m6A RNA甲基化酶抑制剂与免疫检查点抑制剂联合治疗肿瘤
WO2024056099A1 (zh) * 2022-09-16 2024-03-21 北京华益健康药物研究中心 Mettl3抑制剂化合物及其药物组合物和应用

Also Published As

Publication number Publication date
WO2020201773A1 (en) 2020-10-08
EP3946618A1 (en) 2022-02-09
JP7762957B2 (ja) 2025-10-31
US20250388577A1 (en) 2025-12-25
US12358915B2 (en) 2025-07-15
JP2022528562A (ja) 2022-06-14
US20230085408A1 (en) 2023-03-16

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