CN113893198A - Efficient bacteriostatic paste and preparation method thereof - Google Patents

Abstract

The invention provides a high-efficiency bacteriostatic paste and a preparation method thereof. The coconut oil, the vitamins, the plant essence and the bioactive peptide can effectively remove bacteria in the oral cavity and improve the oral environment; coconut oil can form a protective layer on the surface of enamel, so that the enamel is prevented from being invaded by bacteria; the vitamins can improve the immunity and antibacterial ability of oral mucosa; the plant essence can remove bacteria and simultaneously avoid redness, swelling, inflammation and the like of the gum; the bioactive peptide can kill bacteria and bacteria. The plant essence is extracted from high-concentration effective components, so that the toothpaste has a quick curative effect compared with the existing toothpaste; the coconut oil, the vitamins and the bioactive peptide components added simultaneously can kill various bacteria, inhibit the propagation of the bacteria and improve the oral environment. Solves the problem of poor antibacterial effect of the existing antibacterial toothpaste.

Description

Efficient bacteriostatic paste and preparation method thereof

Technical Field

The invention relates to the technical field of oral care, in particular to a high-efficiency antibacterial paste and a preparation method thereof.

Background

With the improvement of the quality of life of substances of people, oral diseases also become one of the diseases which are not neglected by people. Mild oral diseases may cause halitosis, dry mouth, sore gums, etc., while severe oral diseases may induce cardiovascular diseases or other disorders in addition to inflammation of gums, ulceration, etc. Therefore, daily care of the oral cavity is important.

Currently, the most common oral care is brushing, gargling, etc., and additionally includes cleaning with a floss or tongue brush, as well as regular oral examinations and cleaning. In order to ensure the effect of brushing teeth, the toothpaste is usually used in combination with the mechanical friction of the toothbrush to clean the teeth and their surroundings, so as to make the oral cavity clean and refreshing.

However, the existing toothpaste only primarily cleans the oral cavity to remove food residues, peculiar smell and the like in the oral cavity, but bacteria remained in the oral cavity cannot be effectively cleaned, and the bacteria breed greatly over time to cause the oral environment to be poor, thereby inducing oral diseases.

In order to remove and inhibit the proliferation of bacteria in the oral cavity, a great deal of research has been conducted and toothpastes having antibacterial effects have been proposed. For example, patent application No. 202010160530.8 entitled "method for preparing antibacterial paste for oral care" discloses a method for preparing antibacterial paste, which comprises premixing bisabolol and ginger root extract, and adding mixture of cocamidopropyl betaine, lauryl alcohol sulfate, and pentanediol to improve premixing effect of bisabolol and ginger root extract and improve use effect of antibacterial paste. And as the patent application number is 202010906091.0, the name is 'an antibacterial and anti-inflammatory formula and antibacterial and anti-inflammatory toothpaste' which discloses a toothpaste containing zedoary turmeric oil, coconut oil, peppermint oil, oregano oil, chrysanthemum oil and green tea extract, wherein natural plant components are effectively compounded, the toothpaste can inhibit the breeding and propagation of various oral harmful bacteria on the surfaces of oral cavities and teeth, prevent halitosis, refresh breath and has long acting force.

However, most of the existing antibacterial toothpaste can inhibit bacteria of a single bacterium (such as helicobacter pylori), and the oral environment has a plurality of bacteria, so that the antibacterial effect is limited. In addition, most of antibacterial ingredients in the existing antibacterial toothpaste are traditional Chinese medicine components, and the antibacterial effect is realized through a traditional Chinese medicine prescription, but the traditional Chinese medicine components have slow effect and have certain side effects, so that the antibacterial effect is poor.

Disclosure of Invention

The invention aims to provide a high-efficiency bacteriostatic paste and a preparation method thereof, and at least solves the problem of poor bacteriostatic effect of the existing bacteriostatic toothpaste.

In order to solve the technical problems, the invention provides a high-efficiency bacteriostatic paste which comprises 50-70% of a substrate, 5-12% of coconut oil, 3-6% of vitamins, 8-24% of plant essence and 13-25% of bioactive peptide by mass.

Optionally, in the efficient bacteriostatic paste, the matrix comprises 45-64% by mass of a wetting agent, 2.2-4.6% by mass of an adhesive, 3.6-7.4% by mass of a foaming agent, 8-15% by mass of a friction agent, and the balance deionized water.

Optionally, in the high-efficiency bacteriostatic paste, the wetting agent includes one or more of propylene glycol, polyethylene glycol, cyclohexanol and sorbitol; the adhesive comprises one or more of sodium carboxymethylcellulose, hydroxyethyl cellulose, carrageenan, guar gum and xanthan gum; the foaming agent comprises sodium dodecyl sulfate and surface active peptide; the abrasive comprises calcium carbonate, calcium bicarbonate, silica powder and sepiolite.

Optionally, in the high-efficiency bacteriostatic cream, the wetting agent comprises 22-35% by mass of propylene glycol, 18-30% by mass of polyethylene glycol, 6-17% by mass of cyclohexanol and 30-45% by mass of sorbitol; the adhesive comprises 12-20% of sodium carboxymethylcellulose, 15-25% of hydroxyethyl cellulose and 60-82% of carrageenan by mass percent; the foaming agent comprises sodium dodecyl sulfate and surface active peptide in a mass ratio of 35: 65-48: 52; the friction agent comprises 55-64% of calcium bicarbonate, 18-32% of silica powder and 12-24% of sepiolite by mass.

Optionally, in the high-efficiency bacteriostatic paste, the wetting agent is sorbitol; the adhesive is xanthan gum; the foaming agent is surface active peptide; the friction agent comprises calcium carbonate and silica powder in a mass ratio of 6: 4-8: 2.

Optionally, in the high-efficiency bacteriostatic paste, the vitamins include, by mass, 22-38% of vitamin a, 15-25% of vitamin B2, 18-32% of vitamin B6, and 25-36% of vitamin E; the plant essence is prepared from herba Sonchi Oleracei, semen Armeniacae amarum, flos Lonicerae, herba Portulacae, Prunellae Spica, rhizoma Belamcandae, herba Solani Lyrati, Perillae herba, lemon oil and oleum Menthae Dementholatum; the bioactive peptide comprises nisin, bacitracin, cecropin and endorphin.

Optionally, in the high-efficiency bacteriostatic paste, every 100ml of plant essence is prepared from 5-8 g of endive, 6-10 g of bitter celery, 5-10 g of bitter almond, 6-9 g of honeysuckle, 10-15 g of purslane, 6-10 g of selfheal, 8-12 g of blackberrylily rhizome, 5-8 g of solanum lyratum, 12-16 g of perilla, 8-10 ml of lemon oil and 5-8 ml of mint oil.

In order to solve the technical problems, the invention also provides a preparation method of the high-efficiency bacteriostatic paste, which is used for preparing the high-efficiency bacteriostatic paste, and the preparation method comprises the following steps:

preparing raw materials including wetting agent, adhesive, foaming agent, friction agent, coconut oil, vitamins, herba Sonchi Oleracei, semen Armeniacae amarum, flos Lonicerae, herba Portulacae, Prunellae Spica, rhizoma Belamcandae, herba Solani Lyrati, Perillae herba, lemon oil, oleum Menthae Dementholatum, bioactive peptide and deionized water;

preparing plant essence;

pouring the plant essence and the vitamins into coconut oil according to a preset proportion, and stirring and mixing uniformly to obtain an antibacterial ointment;

preparing a matrix by using a wetting agent, an adhesive, a foaming agent, an abrasive and deionized water;

pouring the antibacterial ointment into the matrix according to a preset proportion, and uniformly stirring and mixing to obtain an antibacterial matrix;

adding a preset amount of bioactive peptide into the bacteriostatic matrix at the ambient temperature of 15-23 ℃ and the ambient humidity of 45-60%, and uniformly stirring and mixing to obtain a semi-finished paste;

and (4) performing vacuum dehumidification on the semi-finished paste until the water content in the semi-finished paste is lower than 35% so as to obtain the high-efficiency antibacterial paste.

Optionally, in the preparation method of the high-efficiency bacteriostatic cream, the method for preparing the plant essence comprises the following steps:

pulverizing herba Sonchi arvensis, herba Ixeritis Sonchifoliae, semen Armeniacae amarum, flos Lonicerae, herba Portulacae, Prunellae Spica, rhizoma Belamcandae, herba Solani Lyrati and Perillae herba, and mixing at a preset ratio to obtain plant powder;

pouring the plant powder into 10-20 times of purified water for boiling, and continuously boiling for 4-8 hours after the water is boiled;

filtering to obtain plant soup and plant ointment, wherein the maximum particle size of the particles in the plant soup is not more than 150 μm;

concentrating the plant soup to obtain a plant concentrated solution, wherein the volume of the plant concentrated solution is 1/10-1/8 of the volume of the original plant soup;

cooling until the temperature of the plant concentrated solution is normal temperature;

adding a preset amount of lemon oil and peppermint oil dropwise into the plant concentrate to obtain plant essence.

Optionally, in the preparation method of the highly effective bacteriostatic cream, the method for preparing the matrix includes:

keeping the temperature of the deionized water at 0-15 ℃, adding a preset amount of wetting agent, and uniformly stirring;

keeping the temperature unchanged, adding a preset amount of adhesive and a friction agent, and uniformly stirring;

keeping the temperature unchanged, adding a preset amount of foaming agent, and uniformly stirring to obtain a matrix liquid, wherein the stirring speed is 10-15 r/min;

heating to 40-45 ℃, keeping the stirring speed unchanged, volatilizing the moisture in the matrix liquid, and stopping heating until the water content in the matrix liquid is not higher than 75%;

and keeping the stirring speed unchanged after stopping heating, and continuously stirring for 20-30 min to stop stirring to obtain the matrix.

The efficient bacteriostatic cream and the preparation method thereof provided by the invention comprise 50-70% of matrix, 5-12% of coconut oil, 3-6% of vitamins, 8-24% of plant essence and 13-25% of bioactive peptide by mass percentage. The coconut oil, the vitamins, the plant essence and the bioactive peptide can effectively remove bacteria in the oral cavity and improve the oral environment; coconut oil can form a protective layer on the surface of enamel, so that the enamel is prevented from being invaded by bacteria; the vitamins can improve the immunity and antibacterial ability of oral mucosa; the plant essence can remove bacteria and simultaneously avoid redness, swelling, inflammation and the like of the gum; the bioactive peptide can kill bacteria and bacteria. The plant essence is extracted from high-concentration effective components, so that the toothpaste has a quick curative effect compared with the existing toothpaste; the coconut oil, the vitamins and the bioactive peptide components added simultaneously can kill various bacteria, inhibit the propagation of the bacteria and improve the oral environment. Solves the problem of poor antibacterial effect of the existing antibacterial toothpaste.

Drawings

Fig. 1 is a flow chart of a manufacturing method of the efficient bacteriostatic cream provided by the embodiment.

Detailed Description

The efficient bacteriostatic cream and the preparation method thereof provided by the invention are further described in detail with reference to the accompanying drawings and specific examples. It is to be noted that the drawings are in a very simplified form and are not to precise scale, which is merely for the purpose of facilitating and distinctly claiming the embodiments of the present invention. Further, the structures illustrated in the drawings are often part of actual structures. In particular, the drawings may have different emphasis points and may sometimes be scaled differently.

It should be noted that the terms "comprises" and "comprising," and any variations thereof, in the description and claims of the present invention and the accompanying drawings, are intended to cover a non-exclusive inclusion, such that a process, method, system, article, or apparatus that comprises a list of steps or elements is not necessarily limited to those steps or elements expressly listed, but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.

According to research, the bacteria affecting oral hygiene and health in the oral cavity mainly comprise helicobacter pylori, streptococcus mutans, porphyromonas gingivalis and the like.

Helicobacter Pylori (HP) is a very important pathogenic bacterium in the gastrointestinal tract, and is closely related to diseases such as gastritis, peptic ulcer and even gastric cancer. In recent years, researches prove that a certain amount of HP also exists in the oral cavity of human beings, and the oral cavity is highly homologous with the HP of gastric mucosa, and can cause various oral diseases such as periodontitis, halitosis, glossitis, oral lichen planus, oral recurrent aphthous ulcer and the like to a certain extent as oral pathogenic bacteria.

Streptococcus mutans and Porphyromonas gingivalis are two important and common pathogenic bacteria causing dental caries and periodontal disease. Among them, Streptococcus mutans is a gram-positive coccus, one of the Streptococcus species that accounts for the largest proportion of the oral natural flora, and is one of the main components of dental plaque. Porphyromonas gingivalis, a non-glycolytic gram-negative anaerobic coccobacillus, causes periodontal disease, can cause not only inflammation, but also now common antibiotic resistance, and once uncontrolled, it eventually causes the teeth to fall off the gums.

The three main bacteria in the oral cavity have different reproduction modes, bacteriostatic medicines and the like, so the existing bacteriostatic toothpaste has poor bacteriostatic effect. In view of the above, there is a need to provide a toothpaste that can simultaneously combat the above three bacteria.

The embodiment provides a high-efficiency bacteriostatic paste, which comprises 50-70% of a substrate, 5-12% of coconut oil, 3-6% of vitamins, 8-24% of plant essence and 13-25% of bioactive peptide by mass.

According to the efficient antibacterial paste provided by the embodiment, the coconut oil, the vitamins, the plant essence and the bioactive peptide can effectively remove bacteria in the oral cavity and improve the oral environment; coconut oil can form a protective layer on the surface of enamel, so that the enamel is prevented from being invaded by bacteria; the vitamins can improve the immunity and antibacterial ability of oral mucosa; the plant essence can remove bacteria and simultaneously avoid redness, swelling, inflammation and the like of the gum; the bioactive peptide can kill bacteria and bacteria. The plant essence is extracted from high-concentration effective components, so that the toothpaste has a quick curative effect compared with the existing toothpaste; the coconut oil, the vitamins and the bioactive peptide components added simultaneously can kill various bacteria, inhibit the propagation of the bacteria and improve the oral environment. Solves the problem of poor antibacterial effect of the existing antibacterial toothpaste.

Specifically, in this embodiment, the matrix includes 45% to 64% by mass of a wetting agent, 2.2% to 4.6% by mass of an adhesive, 3.6% to 7.4% by mass of a foaming agent, 8% to 15% by mass of a friction agent, and the balance deionized water.

It should be noted that the paste base used in this example is a base conventionally used in existing toothpaste. In the specific application process, other preparations such as essence, saccharin, thickener, antiseptic, whitening agent, etc. can also be added. The composition of the matrix within a few days without departing from the spirit of the invention is also intended to be within the scope of the invention.

Further, in this embodiment, the wetting agent may be specifically selected from one or more of propylene glycol, polyethylene glycol, cyclohexanol, and sorbitol; the adhesive can be selected from one or more of sodium carboxymethylcellulose, hydroxyethyl cellulose, carrageenan, guar gum and xanthan gum; the foaming agent can be selected from sodium dodecyl sulfate and surface active peptide; the abrasive can be calcium carbonate, calcium bicarbonate, silica powder and sepiolite.

This embodiment provides a preferred matrix composition comprising: the wetting agent comprises 22-35% by mass of propylene glycol, 18-30% by mass of polyethylene glycol, 6-17% by mass of cyclohexanol and 30-45% by mass of sorbitol; the adhesive comprises 12-20% of sodium carboxymethylcellulose, 15-25% of hydroxyethyl cellulose and 60-82% of carrageenan by mass percent; the foaming agent comprises sodium dodecyl sulfate and surface active peptide in a mass ratio of 35: 65-48: 52; the friction agent comprises 55-64% of calcium bicarbonate, 18-32% of silica powder and 12-24% of sepiolite by mass.

Because each preparation is a mixture of a plurality of components, the components in the paste can be well compatible in the final processing technology; the added surface active peptide can generate rich foam and play a certain role in sterilizing and purifying the oral cavity; the added silica powder and sepiolite can whiten teeth to a certain extent.

This example also provides another preferred matrix composition comprising: the wetting agent is sorbitol; the adhesive is xanthan gum; the foaming agent is surface active peptide; the friction agent comprises calcium carbonate and silica powder in a mass ratio of 6: 4-8: 2.

The components are single, and the complexity of the production process and the manufacturing cost can be effectively reduced.

In the embodiment, the vitamins comprise 22-38% by mass of vitamin A, 15-25% by mass of vitamin B2, 18-32% by mass of vitamin B6 and 25-36% by mass of vitamin E.

The vitamins in the embodiment are multi-vitamin compound vitamins, can effectively inhibit bacteria, improve the immunity and self-repairing capability of oral mucosa, and can prevent bacterial infection, gingival red swelling and bleeding and the like.

Further, in this embodiment, the plant essence is made from herba Sonchi Oleracei, semen Armeniacae amarum, flos Lonicerae, herba Portulacae, Spica Prunellae, rhizoma Belamcandae, herba Solani Lyrati, Perillae herba, lemon oil and oleum Menthae Dementholatum.

The ground fine powder of each plant is not directly added into the paste provided by the embodiment, but the essence of each plant is extracted through a certain process, and the essence (water and oil) is added into the paste, so that the traditional Chinese medicine curative effect of the plants is more remarkable, the traditional Chinese medicine can act on the oral cavity in a shorter time, the oral environment is improved, and the damage to enamel during tooth brushing caused by the fine powder of the plants can be avoided.

Specifically, in the embodiment, each 100ml of the plant essence is prepared from 5-8 g of endive, 6-10 g of bitter celery, 5-10 g of bitter apricot kernel, 6-9 g of honeysuckle, 10-15 g of purslane, 6-10 g of selfheal, 8-12 g of blackberry lily, 5-8 g of solanum lyratum, 12-16 g of perilla, 8-10 ml of lemon oil and 5-8 ml of peppermint oil.

The proportion of each plant is strictly controlled, so that the bacteriostatic effect is optimal.

Still further, in this embodiment, the bioactive peptides include nisin, bacitracin, cecropin, endorphin.

Nisin is able to inhibit the growth and reproduction of many gram-positive bacteria that cause food spoilage, including staphylococci, streptococci (including Streptococcus mutans), micrococcus, and the like. The antibacterial effect of bacitracin is similar to that of penicillin, and it has bactericidal effect on gram-positive bacteria, gram-negative coccus, pneumococci, staphylococcus, gonococcus, helicobacter pylori, meningococcus, spirochete and others. The cecropin can resist and inhibit bacteria, and can also improve the antibacterial activity of other bioactive peptides, so that the antibacterial action time is longer and the effect is better. Endorphins are analgesic agents, and when diseases such as inflammation, ulcer, etc. exist in the oral cavity, the pain of the oral cavity can be relieved by endorphins.

The bioactive peptide can effectively inhibit the reproduction of various pathogenic bacteria in the oral cavity and has no adverse effect on the oral environment.

The embodiment also provides a preparation method of the efficient bacteriostatic paste, as shown in fig. 1, the preparation method comprises the following steps:

s1, preparing raw materials including wetting agent, adhesive, foaming agent, friction agent, coconut oil, vitamins, herba Sonchi arvensis, semen Armeniacae amarum, flos Lonicerae, herba Portulacae, Prunellae Spica, rhizoma Belamcandae, herba Solani Lyrati, Perillae herba, lemon oil, oleum Menthae Dementholatum, bioactive peptide and deionized water;

s2, preparing plant essence;

s3, pouring the plant essence and the vitamins into coconut oil according to a preset proportion, and stirring and mixing uniformly to obtain an antibacterial ointment;

s4, preparing a matrix by using a wetting agent, an adhesive, a foaming agent, a friction agent and deionized water;

s5, pouring the antibacterial ointment into the matrix according to a preset proportion, and stirring and mixing uniformly to obtain an antibacterial matrix;

s6, adding a preset amount of bioactive peptide into the bacteriostatic matrix at the ambient temperature of 15-23 ℃ and the ambient humidity of 45-60%, and uniformly stirring and mixing to obtain a semi-finished paste;

s7, performing vacuum dehumidification on the semi-finished paste until the water content in the semi-finished paste is lower than 35% to obtain the high-efficiency antibacterial paste.

It should be noted that the manufacturing method provided by this embodiment omits other conventional methods required in the actual production process; and in the practical application process, the processing processes of the components can be carried out simultaneously or the sequence can be interchanged. Other methods of fabrication without departing from the spirit of the invention are also within the scope of the invention.

Specifically, in this embodiment, the method for preparing the plant essence includes:

s21, grinding and mixing the common sowthistle herb, the bitter celery, the bitter apricot seed, the honeysuckle, the purslane, the selfheal, the blackberry lily, the bittersweet herb and the perilla frutescens according to a preset proportion to obtain plant powder;

s22, pouring the plant powder into 10-20 times of purified water for boiling, and continuously boiling for 4-8 hours after the water is boiled;

s23, filtering to obtain plant soup and plant ointment, wherein the maximum particle size of particles in the plant soup is not more than 150 μm;

s24, concentrating the plant soup to obtain a plant concentrated solution, wherein the volume of the plant concentrated solution is 1/10-1/8 of the volume of the original plant soup;

s25, cooling until the temperature of the plant concentrated solution is normal temperature;

s26, adding a predetermined amount of lemon oil and peppermint oil dropwise to the plant concentrate to obtain a plant essence.

Therefore, the effective components of all the plants are fully dissolved into the concentrated solution, and the effective components of the concentrated solution in unit volume can be effectively inhibited from bacteria during tooth brushing.

Further, in this embodiment, the method for preparing the substrate includes:

s41, keeping the temperature of the deionized water at 0-15 ℃, adding a preset amount of wetting agent, and uniformly stirring;

s42, keeping the temperature unchanged, adding a preset amount of adhesive and friction agent, and uniformly stirring;

s43, keeping the temperature unchanged, adding a preset amount of foaming agent, and uniformly stirring to obtain a matrix liquid, wherein the stirring speed is 10-15 r/min;

s44, heating to 40-45 ℃, keeping the stirring speed unchanged, volatilizing the moisture in the matrix liquid, and stopping heating until the water content in the matrix liquid is not higher than 75%;

and S45, keeping the stirring speed unchanged after stopping heating, and continuously stirring for 20-30 min to stop stirring to obtain the matrix.

The efficient bacteriostatic paste and the preparation method thereof provided by the invention are described in two specific examples below.

[ EXAMPLES one ]

In this embodiment, the ointment includes 60% by mass of a base, 10% by mass of coconut oil, 5% by mass of vitamins, 10% by mass of plant essence, and 15% by mass of bioactive peptide.

The matrix comprises 50 mass percent of wetting agent, 3 mass percent of adhesive, 5 mass percent of foaming agent, 12 mass percent of friction agent and 30 mass percent of deionized water. Specifically, the wetting agent comprises 30 mass percent of propylene glycol, 20 mass percent of polyethylene glycol, 10 mass percent of cyclohexanol and 40 mass percent of sorbitol; the adhesive comprises 20 mass percent of sodium carboxymethylcellulose, 20 mass percent of hydroxyethyl cellulose and 60 mass percent of carrageenan; the foaming agent comprises lauryl sodium sulfate and surface active peptide in a mass ratio of 40: 60; the friction agent comprises 55 mass percent of calcium bicarbonate, 25 mass percent of silica powder and 20 mass percent of sepiolite.

The vitamins comprise 25% of vitamin A, 20% of vitamin B2, 20% of vitamin B6 and 35% of vitamin E.

The plant essence is prepared from herba Sonchi Oleracei, semen Armeniacae amarum, flos Lonicerae, herba Portulacae, Prunellae Spica, rhizoma Belamcandae, herba Solani Lyrati, Perillae herba, lemon oil and oleum Menthae Dementholatum. Wherein, per 100ml of plant essence, 8g of endive, 8g of bitter celery, 10g of bitter apricot seed, 8g of honeysuckle, 12g of purslane, 10g of selfheal, 10g of blackberry lily, 6g of solanum lyratum, 15g of perilla, 10ml of lemon oil and 6ml of peppermint oil are needed.

The bioactive peptide comprises 40% of nisin, 35% of bacitracin, 15% of cecropin and 10% of endorphin.

Firstly, crushing, decocting, filtering and concentrating preset amounts of endive, bitter celery, bitter almond, honeysuckle, purslane, selfheal, blackberry lily, bittersweet herb and perilla according to the steps, and then adding lemon oil and peppermint oil to obtain plant essence.

Then, propylene glycol, polyethylene glycol, cyclohexanol, sorbitol, sodium carboxymethylcellulose, hydroxyethyl cellulose, carrageenan, sodium lauryl sulfate, surface active peptide, calcium bicarbonate, silica powder, sepiolite and deionized water in preset amounts are used for preparing the matrix according to the steps.

Then, pouring plant essence and vitamins into coconut oil according to a preset proportion, and stirring and mixing uniformly to obtain antibacterial ointment; and pouring the antibacterial ointment into the matrix according to a preset proportion, and stirring and mixing uniformly to obtain the antibacterial matrix.

And then, adding a preset amount of bioactive peptide into the bacteriostatic matrix at the ambient temperature of 20 ℃ and the ambient humidity of 48%, and uniformly stirring and mixing to obtain a semi-finished paste.

And finally, performing vacuum dehumidification on the semi-finished paste until the water content in the semi-finished paste is lower than 35% so as to obtain the high-efficiency antibacterial paste.

The paste provided in this example was used for brushing teeth, and the number of bacteria before and after brushing was counted as shown in table 1 below:

item	Before brushing teeth	After brushing teeth	6 hours after tooth brushing	12h after tooth brushing
					Helicobacter pylori	226	14	26	58
Streptococcus mutans	218	8	12	33
					Porphyromonas gingivalis	308	17	25	60
Breath of mouth	Heavy weight	Is free of	Is free of	Light and slight
					Gum	Slight red and swollen	No inflammation and red swelling	No inflammation and red swelling	No inflammation and red swelling
Tooth enamel	Residual impurities at tooth root	No impurity residue	No impurity residue	No impurity residue

TABLE 1 comparison of the number of bacteria in the oral cavity before and after brushing of the paste provided in example one

The table shows the number of bacteria per unit area (5 × 5mm), and the samples were selected at random. In addition, the number of bacteria is an average value after counting 10 samples; breath, gum and enamel data were selected to compare the worst overall quality of one sample prior to brushing.

As can be seen from table 1, the high-efficiency antibacterial paste provided by the embodiment has a good antibacterial effect, can remove a large amount of bacteria in the oral cavity after tooth cleaning, can effectively improve the problems of bad breath and red and swollen gums, and can be cleaned cleanly to improve oral health. In addition, the number of bacteria in the oral cavity was kept in a low range at 12 hours after brushing, indicating that the cream provided by this example is effective in inhibiting the growth of bacteria.

[ example two ]

In this embodiment, the ointment includes, by mass, 50% of a base, 10% of coconut oil, 5% of vitamins, 18% of plant essence, and 17% of bioactive peptide.

The matrix comprises 60 mass percent of wetting agent, 4 mass percent of adhesive, 6 mass percent of foaming agent, 15 mass percent of friction agent and 15 mass percent of deionized water. Specifically, the wetting agent is sorbitol; the adhesive is xanthan gum; the foaming agent is surface active peptide; the friction agent comprises calcium carbonate and silica powder in a mass ratio of 6: 4.

The vitamins comprise 30% of vitamin A, 25% of vitamin B2, 20% of vitamin B6 and 25% of vitamin E.

The plant essence is prepared from herba Sonchi Oleracei, semen Armeniacae amarum, flos Lonicerae, herba Portulacae, Prunellae Spica, rhizoma Belamcandae, herba Solani Lyrati, Perillae herba, lemon oil and oleum Menthae Dementholatum. Wherein, each 100ml of plant essence needs 6g of endive, 10g of bitter celery, 8g of bitter apricot seed, 8g of honeysuckle, 15g of purslane, 8g of selfheal, 8g of blackberry lily, 8g of solanum lyratum, 12g of perilla, 10ml of lemon oil and 8ml of peppermint oil.

The bioactive peptide comprises 40% of nisin, 40% of bacitracin, 10% of cecropin and 10% of endorphin.

Firstly, crushing, decocting, filtering and concentrating preset amounts of endive, bitter celery, bitter almond, honeysuckle, purslane, selfheal, blackberry lily, bittersweet herb and perilla according to the steps, and then adding lemon oil and peppermint oil to obtain plant essence.

Then, a substrate is prepared by using sorbitol, xanthan gum, surface active peptide, calcium carbonate, silica powder and deionized water in preset amounts according to the steps.

Then, pouring plant essence and vitamins into coconut oil according to a preset proportion, and stirring and mixing uniformly to obtain antibacterial ointment; and pouring the antibacterial ointment into the matrix according to a preset proportion, and stirring and mixing uniformly to obtain the antibacterial matrix.

And then, adding a preset amount of bioactive peptide into the bacteriostatic matrix at the ambient temperature of 22 ℃ and the ambient humidity of 50%, and uniformly stirring and mixing to obtain a semi-finished paste.

And finally, performing vacuum dehumidification on the semi-finished paste until the water content in the semi-finished paste is lower than 35% so as to obtain the high-efficiency antibacterial paste.

The paste provided in this example was used for brushing teeth, and the number of bacteria before and after brushing was counted as shown in table 2 below:

item	Before brushing teeth	After brushing teeth	6 hours after tooth brushing	12h after tooth brushing
					Helicobacter pylori	230	8	19	54
Streptococcus mutans	197	4	8	26
					Porphyromonas gingivalis	256	12	27	64
Breath of mouth	Heavy weight	Is free of	Is free of	Light and slight
					Gum	Bleeding	Slight red swelling after hemostasis	No inflammation and red swelling	No inflammation and red swelling
Tooth enamel	Dental calculus at tooth root	Dental calculus softening	Tartar reduction	Tartar reduction

TABLE 2 comparison of the number of bacteria in the oral cavity before and after brushing of the pastes provided in example two

The table shows the number of bacteria per unit area (5 × 5mm), and the samples were selected at random. In addition, the number of bacteria is an average value after counting 10 samples; breath, gum and enamel data were selected to compare the worst overall quality of one sample prior to brushing.

As can be seen from table 2, the high-efficiency antibacterial paste provided by the embodiment has a good antibacterial effect, can remove a large amount of bacteria in the oral cavity after tooth cleaning, can effectively improve the problems of bad breath and red and swollen gums, and can be cleaned cleanly to improve oral health. When tartar exists, the toothpaste provided by the embodiment can effectively soften tartar, so that the accumulation of tartar is reduced along with the actions of drinking water, gargling and the like in the later period; the toothpaste provided by the embodiment can be used for a long time, so that tartar can be completely removed, and tartar regeneration can be prevented. In addition, the number of bacteria in the oral cavity was kept in a low range at 12 hours after brushing, indicating that the cream provided by this example is effective in inhibiting the growth of bacteria.

It should be noted that, in the present specification, the embodiments are described in a progressive manner, each embodiment focuses on differences from other embodiments, similar parts between the embodiments may be referred to each other, and different parts between the embodiments may also be used in combination with each other, which is not limited by the present invention.

In summary, the efficient bacteriostatic cream and the preparation method thereof provided by the embodiment include, by mass, 50% to 70% of a base, 5% to 12% of coconut oil, 3% to 6% of vitamins, 8% to 24% of plant essence, and 13% to 25% of bioactive peptide. The coconut oil, the vitamins, the plant essence and the bioactive peptide can effectively remove bacteria in the oral cavity and improve the oral environment; coconut oil can form a protective layer on the surface of enamel, so that the enamel is prevented from being invaded by bacteria; the vitamins can improve the immunity and antibacterial ability of oral mucosa; the plant essence can remove bacteria and simultaneously avoid redness, swelling, inflammation and the like of the gum; the bioactive peptide can kill bacteria and bacteria. The plant essence is extracted from high-concentration effective components, so that the toothpaste has a quick curative effect compared with the existing toothpaste; the coconut oil, the vitamins and the bioactive peptide components added simultaneously can kill various bacteria, inhibit the propagation of the bacteria and improve the oral environment. Solves the problem of poor antibacterial effect of the existing antibacterial toothpaste.

The above description is only for the purpose of describing the preferred embodiments of the present invention, and is not intended to limit the scope of the present invention, and any variations and modifications made by those skilled in the art based on the above disclosure are within the scope of the appended claims.

Claims (10)

1. The efficient bacteriostatic cream is characterized by comprising 50-70% of a matrix, 5-12% of coconut oil, 3-6% of vitamins, 8-24% of plant essence and 13-25% of bioactive peptide by mass.

2. The efficient bacteriostatic paste according to claim 1, wherein the matrix comprises 45-64% by mass of a wetting agent, 2.2-4.6% by mass of an adhesive, 3.6-7.4% by mass of a foaming agent, 8-15% by mass of a friction agent, and the balance of deionized water.

3. The highly effective bacteriostatic cream of claim 2, wherein the humectant comprises one or more of propylene glycol, polyethylene glycol, cyclohexanol and sorbitol; the adhesive comprises one or more of sodium carboxymethylcellulose, hydroxyethyl cellulose, carrageenan, guar gum and xanthan gum; the foaming agent comprises sodium dodecyl sulfate and surface active peptide; the abrasive comprises calcium carbonate, calcium bicarbonate, silica powder and sepiolite.

4. The efficient bacteriostatic cream according to claim 3, wherein the wetting agent comprises 22-35% by mass of propylene glycol, 18-30% by mass of polyethylene glycol, 6-17% by mass of cyclohexanol and 30-45% by mass of sorbitol; the adhesive comprises 12-20% of sodium carboxymethylcellulose, 15-25% of hydroxyethyl cellulose and 60-82% of carrageenan by mass percent; the foaming agent comprises sodium dodecyl sulfate and surface active peptide in a mass ratio of 35: 65-48: 52; the friction agent comprises 55-64% of calcium bicarbonate, 18-32% of silica powder and 12-24% of sepiolite by mass.

5. The highly effective bacteriostatic cream according to claim 3, wherein the wetting agent is sorbitol; the adhesive is xanthan gum; the foaming agent is surface active peptide; the friction agent comprises calcium carbonate and silica powder in a mass ratio of 6: 4-8: 2.

6. The efficient bacteriostatic paste according to claim 1, wherein the vitamins comprise 22-38% by mass of vitamin A, 15-25% by mass of vitamin B2, 18-32% by mass of vitamin B6 and 25-36% by mass of vitamin E; the plant essence is prepared from herba Sonchi Oleracei, semen Armeniacae amarum, flos Lonicerae, herba Portulacae, Prunellae Spica, rhizoma Belamcandae, herba Solani Lyrati, Perillae herba, lemon oil and oleum Menthae Dementholatum; the bioactive peptide comprises nisin, bacitracin, cecropin and endorphin.

7. The efficient bacteriostatic paste according to claim 6, wherein each 100ml of plant essence is prepared from 5-8 g of endive, 6-10 g of bitter celery, 5-10 g of bitter apricot seed, 6-9 g of honeysuckle, 10-15 g of purslane, 6-10 g of selfheal, 8-12 g of blackberry lily, 5-8 g of solanum lyratum, 12-16 g of perilla, 8-10 ml of lemon oil and 5-8 ml of peppermint oil.

8. A preparation method of the high-efficiency bacteriostatic paste, which is used for preparing the high-efficiency bacteriostatic paste as claimed in any one of claims 1-7, and is characterized by comprising the following steps:

preparing raw materials including wetting agent, adhesive, foaming agent, friction agent, coconut oil, vitamins, herba Sonchi Oleracei, semen Armeniacae amarum, flos Lonicerae, herba Portulacae, Prunellae Spica, rhizoma Belamcandae, herba Solani Lyrati, Perillae herba, lemon oil, oleum Menthae Dementholatum, bioactive peptide and deionized water;

preparing plant essence;

pouring the plant essence and the vitamins into coconut oil according to a preset proportion, and stirring and mixing uniformly to obtain an antibacterial ointment;

preparing a matrix by using a wetting agent, an adhesive, a foaming agent, an abrasive and deionized water;

pouring the antibacterial ointment into the matrix according to a preset proportion, and uniformly stirring and mixing to obtain an antibacterial matrix;

adding a preset amount of bioactive peptide into the bacteriostatic matrix at the ambient temperature of 15-23 ℃ and the ambient humidity of 45-60%, and uniformly stirring and mixing to obtain a semi-finished paste;

and (4) performing vacuum dehumidification on the semi-finished paste until the water content in the semi-finished paste is lower than 35% so as to obtain the high-efficiency antibacterial paste.

9. The method for preparing efficient bacteriostatic paste according to claim 8, wherein the method for preparing the plant essence comprises the following steps:

pulverizing herba Sonchi arvensis, herba Ixeritis Sonchifoliae, semen Armeniacae amarum, flos Lonicerae, herba Portulacae, Prunellae Spica, rhizoma Belamcandae, herba Solani Lyrati and Perillae herba, and mixing at a preset ratio to obtain plant powder;

pouring the plant powder into 10-20 times of purified water for boiling, and continuously boiling for 4-8 hours after the water is boiled;

filtering to obtain plant soup and plant ointment, wherein the maximum particle size of the particles in the plant soup is not more than 150 μm;

concentrating the plant soup to obtain a plant concentrated solution, wherein the volume of the plant concentrated solution is 1/10-1/8 of the volume of the original plant soup;

cooling until the temperature of the plant concentrated solution is normal temperature;

adding a preset amount of lemon oil and peppermint oil dropwise into the plant concentrate to obtain plant essence.

10. The method for preparing efficient bacteriostatic paste according to claim 8, wherein the method for preparing the matrix comprises the following steps:

keeping the temperature of the deionized water at 0-15 ℃, adding a preset amount of wetting agent, and uniformly stirring;

keeping the temperature unchanged, adding a preset amount of adhesive and a friction agent, and uniformly stirring;

keeping the temperature unchanged, adding a preset amount of foaming agent, and uniformly stirring to obtain a matrix liquid, wherein the stirring speed is 10-15 r/min;

heating to 40-45 ℃, keeping the stirring speed unchanged, volatilizing the moisture in the matrix liquid, and stopping heating until the water content in the matrix liquid is not higher than 75%;

and keeping the stirring speed unchanged after stopping heating, and continuously stirring for 20-30 min to stop stirring to obtain the matrix.

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