CN101829032B - Dual-purpose toothpaste composition and preparation method thereof - Google Patents
Dual-purpose toothpaste composition and preparation method thereof Download PDFInfo
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- CN101829032B CN101829032B CN 201010173263 CN201010173263A CN101829032B CN 101829032 B CN101829032 B CN 101829032B CN 201010173263 CN201010173263 CN 201010173263 CN 201010173263 A CN201010173263 A CN 201010173263A CN 101829032 B CN101829032 B CN 101829032B
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- 239000000203 mixture Substances 0.000 title claims abstract description 48
- 239000000606 toothpaste Substances 0.000 title claims abstract description 31
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 47
- 239000008367 deionised water Substances 0.000 claims abstract description 17
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 17
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims abstract description 16
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000000811 xylitol Substances 0.000 claims abstract description 16
- 229960002675 xylitol Drugs 0.000 claims abstract description 16
- 235000010447 xylitol Nutrition 0.000 claims abstract description 16
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims abstract description 16
- 230000000202 analgesic effect Effects 0.000 claims abstract description 12
- 239000011230 binding agent Substances 0.000 claims abstract description 11
- 239000000080 wetting agent Substances 0.000 claims abstract description 11
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 20
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 20
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 claims description 20
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 18
- 230000000675 anti-caries Effects 0.000 claims description 16
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 16
- 238000000586 desensitisation Methods 0.000 claims description 12
- 229910001631 strontium chloride Inorganic materials 0.000 claims description 11
- AHBGXTDRMVNFER-UHFFFAOYSA-L strontium dichloride Chemical compound [Cl-].[Cl-].[Sr+2] AHBGXTDRMVNFER-UHFFFAOYSA-L 0.000 claims description 11
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 10
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 10
- 239000012459 cleaning agent Substances 0.000 claims description 10
- 235000019264 food flavour enhancer Nutrition 0.000 claims description 10
- 229920000136 polysorbate Polymers 0.000 claims description 10
- 239000004323 potassium nitrate Substances 0.000 claims description 10
- 235000010333 potassium nitrate Nutrition 0.000 claims description 10
- 239000000377 silicon dioxide Substances 0.000 claims description 10
- 235000012239 silicon dioxide Nutrition 0.000 claims description 9
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 8
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 claims description 8
- 229940085605 saccharin sodium Drugs 0.000 claims description 8
- 239000011775 sodium fluoride Substances 0.000 claims description 8
- 235000013024 sodium fluoride Nutrition 0.000 claims description 8
- 229960000414 sodium fluoride Drugs 0.000 claims description 8
- 239000013521 mastic Substances 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 claims description 6
- 108010011485 Aspartame Proteins 0.000 claims description 6
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 6
- 239000002202 Polyethylene glycol Substances 0.000 claims description 6
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims description 6
- 239000000605 aspartame Substances 0.000 claims description 6
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 6
- 235000010357 aspartame Nutrition 0.000 claims description 6
- 229960003438 aspartame Drugs 0.000 claims description 6
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 6
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 6
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 6
- 235000011187 glycerol Nutrition 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 229920000609 methyl cellulose Polymers 0.000 claims description 6
- 239000001923 methylcellulose Substances 0.000 claims description 6
- 229920001223 polyethylene glycol Polymers 0.000 claims description 6
- 229950008882 polysorbate Drugs 0.000 claims description 6
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 6
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 6
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 6
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims description 6
- 229960004711 sodium monofluorophosphate Drugs 0.000 claims description 6
- 229940013618 stevioside Drugs 0.000 claims description 6
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims description 6
- 235000019202 steviosides Nutrition 0.000 claims description 6
- 159000000008 strontium salts Chemical class 0.000 claims description 6
- 239000004376 Sucralose Substances 0.000 claims description 4
- 239000004567 concrete Substances 0.000 claims description 4
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 4
- 239000011698 potassium fluoride Substances 0.000 claims description 4
- 235000003270 potassium fluoride Nutrition 0.000 claims description 4
- 235000019408 sucralose Nutrition 0.000 claims description 4
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims description 4
- -1 abrasive Substances 0.000 claims description 2
- 235000019605 sweet taste sensations Nutrition 0.000 claims description 2
- 230000003266 anti-allergic effect Effects 0.000 abstract description 10
- 230000006870 function Effects 0.000 abstract description 7
- 230000000638 stimulation Effects 0.000 abstract description 3
- 208000002193 Pain Diseases 0.000 abstract description 2
- 239000002537 cosmetic Substances 0.000 abstract description 2
- 230000036407 pain Effects 0.000 abstract description 2
- 241000295644 Staphylococcaceae Species 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 abstract 1
- 235000019634 flavors Nutrition 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 208000002925 dental caries Diseases 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 4
- 239000000551 dentifrice Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 241000194017 Streptococcus Species 0.000 description 2
- 241000194019 Streptococcus mutans Species 0.000 description 2
- 230000000170 anti-cariogenic effect Effects 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 210000003298 dental enamel Anatomy 0.000 description 2
- 210000004268 dentin Anatomy 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 229940091249 fluoride supplement Drugs 0.000 description 2
- 210000000214 mouth Anatomy 0.000 description 2
- 229940093928 potassium nitrate Drugs 0.000 description 2
- 229940013553 strontium chloride Drugs 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000034659 glycolysis Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000003239 periodontal effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
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- Cosmetics (AREA)
Abstract
The invention discloses a dual-purpose toothpaste composition having antiallergic and anticarious functions and a preparation method thereof, which belong to the technical field of preparation of cosmetic preparations. The toothpaste composition is mainly prepared from an analgesic component, an antiallergic and anticarious component, xylitol, a wetting agent, a cleanser, an abrasive, a binder, a flavor and deionized water. The toothpaste composition can effectively inhibit pains caused by the stimulation of machines, temperature, sugar concentration and the like, obviously reduce the number of staphylococci, Lancefield's streptococci and mutans streptococci in oral liquid, and realize antiallergic and anticarious functions.
Description
Technical field
The invention belongs to the preparing technical field of cosmetic formulations, particularly a kind of dual-purpose toothpaste composition and compound method thereof that has simultaneously antiallergic and preventing caries function.
Background technology
When dental caries mainly referred to contain the confectionery thing and under various oral cavity bacterium effects glycolysis occurs, the acid that produces acted on tooth, so that enamel and dentin are destroyed.Hemodia refers to that mainly enamel is destroyed, the dentin expose portion, when being subject to temperature, chemistry and the stimulation such as mechanical draw the sensation of unusually aching.Dental caries and hemodia are common oral health issue, and it directly affects people's quality of life.About the research of antiallergic toothpaste and anti-caries toothpaste has a lot of reports, but the toothpaste that has simultaneously described two kinds of functions rarely has report.Such as " double antianaphylaxis tooth paste that contains potassium salt and strontium salt " (Chinese patent CN1528260), it significantly reduces the permeability of dental tissue by potassium salt and strontium salt, reduces gum edge periodontal tissue to the sensitivity of various stimulations, thereby reaches the desensitization analgesic activity; " anticariogenic dentifrice composition " (Chinese patent CN1171931) causes the vegetative inhibitory action of dental caries by xylitol boil on the nape opposite the mouth intracavity and plays anti-caries effect.Above-mentioned two kinds of dentifrice composition compositions are simple, function can only hold concurrently one or the deflection one, can not reach simultaneously desensitizing anticarious effect.The proportioning of How to choose toothpaste effective ingredient and each component makes its anti-allergic effects and anti-caries effect maximization, is the problem of oral hygiene industry research always.
Summary of the invention
The invention provides a kind of dual-purpose toothpaste composition and compound method thereof that has simultaneously antiallergic and preventing caries function.
Dual-purpose toothpaste composition provided by the invention comprises the desensitization analgesic composition, treatment is irritated and anti-caries composition, wetting agent, cleaning agent, abrasive, binding agent, flavour enhancer and deionized water, and concrete component and content are as follows:
1) the desensitization analgesic composition of 0.5-20 weight portion, preferred 2-10 weight portion, the desensitization analgesic composition is that strontium salt is or/and potassium salt is specially strontium chloride or/and potassium nitrate;
2) the irritated and anti-caries composition of the treatment of 0.05-2 weight portion, preferred 0.1-1 weight portion, the anti-caries composition is fluoride, is specially in sodium fluoride, potassium fluoride, the sodium monofluorophosphate one or more;
3) wetting agent of 1-10 weight portion, preferred 2-5 weight portion, wetting agent is one or more in glycerol, Polyethylene Glycol, polysorbate, the tween;
4) cleaning agent of 0.5-10 weight portion, preferred 1-7 weight portion, cleaning agent is dodecyl sodium sulfate;
5) abrasive of 5-60 weight portion, preferred 20-45 weight portion, abrasive are that the silicon dioxide of 5-15 micron grain size is or/and calcium carbonate;
6) binding agent of 2-30 weight portion, preferred 2-15 weight portion, binding agent is one or more in polyvinylpyrrolidone, methylcellulose, the carboxymethyl cellulose;
7) flavour enhancer of 0.02-2 weight portion, preferred 0.1-1 weight portion, flavour enhancer is one or more in Mentholum, water solublity Herba Menthae brain, Oleum menthae, fruity essence, saccharin sodium, aspartame, sucralose, the stevioside;
8) deionized water of 2-50 weight portion.
Each above-mentioned component is prepared as follows:
A) deionized water is divided into water component 1 and water component 2;
B) in water component 1, add successively component 1), component 2), component 3), component 7), component 4) dissolving, then add component 6) dissolving;
C) in water component 2, add component 5) be uniformly dispersed;
D) with step b) with c) two components of preparation combine and stir and made into mastic in 10-50 minute, namely get dual-purpose toothpaste composition.
Dual-purpose toothpaste composition provided by the invention can also add xylitol, and concrete component and the content of compositions that contains xylitol is as follows:
1) the desensitization analgesic composition of 0.5-20 weight portion, preferred 2-10 weight portion, the desensitization analgesic composition is that strontium salt is or/and potassium salt is specially strontium chloride or/and potassium nitrate;
2) the irritated and anti-caries composition of the treatment of 0.05-2 weight portion, preferred 0.1-1 weight portion, the anti-caries composition is fluoride, is specially in sodium fluoride, potassium fluoride, the sodium monofluorophosphate one or more;
3) xylitol of 1-20 weight portion, preferred 5-12 weight portion, xylitol have simultaneously anti-caries and increase the function of sweet taste;
4) wetting agent of 1-10 weight portion, preferred 2-5 weight portion, wetting agent is one or more in glycerol, Polyethylene Glycol, polysorbate, the tween;
5) cleaning agent of 0.5-10 weight portion, preferred 1-7 weight portion, cleaning agent is dodecyl sodium sulfate;
6) abrasive of 5-60 weight portion, preferred 20-45 weight portion, abrasive are that the silicon dioxide of 5-15 micron grain size is or/and calcium carbonate;
7) binding agent of 2-30 weight portion, preferred 2-15 weight portion, binding agent is one or more in polyvinylpyrrolidone, methylcellulose, the carboxymethyl cellulose;
8) flavour enhancer of 0.02-2 weight portion, preferred 0.1-1 weight portion, flavour enhancer is one or more in Mentholum, water solublity Herba Menthae brain, Oleum menthae, fruity essence, saccharin sodium, aspartame, sucralose, the stevioside;
9) deionized water of 2-50 weight portion.
The dual-purpose toothpaste composition compound method that contains xylitol is:
(1) deionized water is divided into water component 1 and water component 2;
(2) in water component 1, add successively component 1), component 2), component 3), component 4), component 8), component 5) dissolving, then add component 7) dissolving;
(3) in water component 2, add component 6) be uniformly dispersed;
(4) two components of step (2) and (3) preparation are combined and stir become mastic in 10-50 minute, namely get dual-purpose toothpaste composition.
Dentifrice composition provided by the invention can establishment machinery, temperature, sugared concentration etc. stimulate the pain that produces, and obviously reduces the Staphylococcus aureus number in the oral fluid, blue streptococcus number and Streptococcus mutans number, reaches simultaneously desensitization and anticariogenic effect.
The specific embodiment
Following non-limiting example is further narrated the preferred embodiment in the scope of the invention.In the case without departing from the scope of the present invention, a lot of variations of present embodiment are possible.
Embodiment 1
Form weight portion
Strontium chloride 10.00
Potassium nitrate 5.00
Sodium fluoride 0.20
Xylitol 10.50
Glycerol 3.50
Dodecyl sodium sulfate 4.00
Silicon dioxide 6.00
Calcium carbonate 20.00
Polyvinylpyrrolidone 6.00
Saccharin sodium 0.10
Fructus Citri Limoniae essence 0.15
Deionized water 34.55
Prepare as follows according to each component ratio in the upper table:
1. deionized water is divided into water component 1 and water component 2;
2. in water component 1, add successively strontium chloride, potassium nitrate, sodium fluoride, xylitol, glycerol, saccharin sodium, Fructus Citri Limoniae essence and dodecyl sodium sulfate dissolving, then add the polyvinylpyrrolidone dissolving;
3. in water component 2, add calcium carbonate successively, silicon dioxide is uniformly dispersed;
4. two components with step 2 and 3 preparations combine and stir and made into mastic in 35 minutes, namely get dual-purpose toothpaste composition.
Embodiment 2
Form weight portion
Strontium chloride 0.40
Potassium nitrate 2.25
Sodium monofluorophosphate 1.80
Xylitol 16.50
Polyethylene Glycol 3.00
Dodecyl sodium sulfate 8.00
Silicon dioxide 9.00
Calcium carbonate 23.00
Methylcellulose 3.00
Saccharin sodium 0.35
Aspartame 0.10
Deionized water 32.60
Prepare as follows according to each component ratio in the upper table:
1. deionized water is divided into water component 1 and water component 2;
2. in water component 1, add successively strontium chloride, potassium nitrate, sodium monofluorophosphate, xylitol, Polyethylene Glycol, saccharin sodium, aspartame and dodecyl sodium sulfate dissolving, then add the methylcellulose dissolving;
3. in water component 2, add calcium carbonate successively, silicon dioxide is uniformly dispersed;
4. two components with step 2 and 3 preparations combine and stir and made into mastic in 20 minutes, namely get dual-purpose toothpaste composition.
Embodiment 3
Form weight portion
Strontium chloride 6.00
Potassium nitrate 3.00
Sodium fluoride 1.10
Xylitol 2.50
Polysorbate 6.50
Dodecyl sodium sulfate 6.00
Silica 1 8.00
Calcium carbonate 10.00
Carboxymethyl cellulose 12.00
Stevioside 0.20
Fructus Citri Limoniae essence 0.25
Deionized water 34.45
Prepare as follows according to each component ratio in the upper table:
1. deionized water is divided into water component 1 and water component 2;
2. in water component 1, add successively strontium chloride, potassium nitrate, sodium fluoride, xylitol, polysorbate, stevioside, Fructus Citri Limoniae essence and dodecyl sodium sulfate dissolving, then add the carboxymethyl cellulose dissolving;
3. in water component 2, add calcium carbonate successively, silicon dioxide is uniformly dispersed;
4. two components with step 2 and 3 preparations combine and stir and made into mastic in 30 minutes, namely get dual-purpose toothpaste composition.
60 patients that suffer from dental caries and the easy allergy of tooth are divided into five groups, three kinds among the embodiment 1-3 fill a prescription dentifrice compositions and general commercially available antiallergic toothpaste and anti-caries toothpaste matched group are tested.They respectively brush one time tooth sooner or later by daily habits, continue to use toothpaste two months, and begin reaction and the Staphylococcus aureus number the oral fluid, blue streptococcus number and the Streptococcus mutans number that every weekly check patient stimulates mechanical stimulus, thermal stimulus, sugared concentration from second month.
| The antiallergic effective percentage | The anti-caries effective percentage | |
| Embodiment 1 | 92％ | 67％ |
| Embodiment 2 | 92％ | 75％ |
| Embodiment 3 | 92％ | 67％ |
| Antiallergic toothpaste matched group | 67％ | 17％ |
| Anti-caries toothpaste matched group | 17％ | 42％ |
Claims (4)
1. a dual-purpose toothpaste composition is characterized in that, described compositions comprises the desensitization analgesic composition, treatment is irritated and anti-caries composition, wetting agent, cleaning agent, abrasive, binding agent, flavour enhancer and deionized water;
The concrete content of each component is as follows:
1) the desensitization analgesic composition of 0.5-20 weight portion, the desensitization analgesic composition be strontium salt or/and potassium salt is specially strontium chloride and potassium nitrate, perhaps use separately strontium chloride;
2) the irritated and anti-caries composition of the treatment of 0.05-2 weight portion is specially one or more in sodium fluoride, potassium fluoride, the sodium monofluorophosphate;
3) wetting agent of 1-10 weight portion, wetting agent are one or more in glycerol, Polyethylene Glycol, polysorbate, the tween;
4) cleaning agent of 0.5-10 weight portion, cleaning agent are dodecyl sodium sulfate;
5) abrasive of 5-60 weight portion, abrasive are the silicon dioxide of calcium carbonate and 5-15 micron grain size;
6) binding agent of 2-30 weight portion, binding agent are one or more in polyvinylpyrrolidone, methylcellulose, the carboxymethyl cellulose;
7) flavour enhancer of 0.02-2 weight portion, flavour enhancer are one or more in Mentholum, Oleum menthae, fruity essence, saccharin sodium, aspartame, sucralose, the stevioside;
8) deionized water of 2-50 weight portion.
2. prepare the method for dual-purpose toothpaste composition claimed in claim 1, it is characterized in that, each component claimed in claim 1 is prepared as follows:
A. deionized water is divided into water component 1 and water component 2;
B. in water component 1, add successively component 1), component 2), component 3), component 7), component 4) dissolving, then add component 6) dissolving;
C. in water component 2, add component 5) be uniformly dispersed;
D. two components of step B and C preparation are combined and stir and became mastic in 10-50 minute, namely get dual-purpose toothpaste composition.
3. a kind of dual-purpose toothpaste composition according to claim 1 is characterized in that, said composition also contains xylitol, and its concrete component and content are as follows:
1) the desensitization analgesic composition of 0.5-20 weight portion, the desensitization analgesic composition is that strontium salt is or/and potassium salt is specially strontium chloride or/and potassium nitrate;
2) the irritated and anti-caries composition of the treatment of 0.05-2 weight portion is specially one or more in sodium fluoride, potassium fluoride, the sodium monofluorophosphate;
3) xylitol of 1-20 weight portion, xylitol have simultaneously anti-caries and increase the function of sweet taste;
4) wetting agent of 1-10 weight portion, wetting agent are one or more in glycerol, Polyethylene Glycol, polysorbate, the tween;
5) cleaning agent of 0.5-10 weight portion, cleaning agent are dodecyl sodium sulfate;
6) abrasive of 5-60 weight portion, abrasive are the silicon dioxide of calcium carbonate and 5-15 micron grain size;
7) binding agent of 2-30 weight portion, binding agent are one or more in polyvinylpyrrolidone, methylcellulose, the carboxymethyl cellulose;
8) flavour enhancer of 0.02-2 weight portion, flavour enhancer are one or more in Mentholum, Oleum menthae, fruity essence, saccharin sodium, aspartame, sucralose, the stevioside;
9) deionized water of 2-50 weight portion.
4. prepare the method for dual-purpose toothpaste composition claimed in claim 3, it is characterized in that, each component claimed in claim 3 is prepared as follows:
(1) deionized water is divided into water component 1 and water component 2;
(2) in water component 1, add successively component 1), component 2), component 3), component 4), component 8), component 5) dissolving, then add component 7) dissolving;
(3) in water component 2, add component 6) be uniformly dispersed;
(4) two components of step (2) and (3) preparation are combined and stir become mastic in 10-50 minute, namely get dual-purpose toothpaste composition.
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| CN 201010173263 CN101829032B (en) | 2010-05-11 | 2010-05-11 | Dual-purpose toothpaste composition and preparation method thereof |
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| CN 201010173263 CN101829032B (en) | 2010-05-11 | 2010-05-11 | Dual-purpose toothpaste composition and preparation method thereof |
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| CN101829032B true CN101829032B (en) | 2013-02-13 |
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| CN102670457A (en) * | 2012-06-06 | 2012-09-19 | 广州中汉口腔用品有限公司 | Tooth powder and fabrication process thereof |
| CN107496318A (en) * | 2017-07-22 | 2017-12-22 | 李映波 | A kind of desensitizing toothpaste of American-cockroach-extract-containing |
| CN115634162A (en) * | 2022-11-07 | 2023-01-24 | 湖南淼泉生物技术有限公司 | Preparation method of gel for preventing caries and desensitization |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080003187A1 (en) * | 2006-06-30 | 2008-01-03 | Colgate-Palmolive Company | High fluoride ion oral care composition and method for maintaining anticaries activity |
| CN101180099A (en) * | 2005-03-21 | 2008-05-14 | 葛兰素集团有限公司 | Alkyl sulfate free and orthophosphate free dentifrice composition comprising a fluoride source and a silica dental abrasive |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101180099A (en) * | 2005-03-21 | 2008-05-14 | 葛兰素集团有限公司 | Alkyl sulfate free and orthophosphate free dentifrice composition comprising a fluoride source and a silica dental abrasive |
| US20080003187A1 (en) * | 2006-06-30 | 2008-01-03 | Colgate-Palmolive Company | High fluoride ion oral care composition and method for maintaining anticaries activity |
| CN101484123A (en) * | 2006-06-30 | 2009-07-15 | 高露洁-棕榄公司 | High fluoride ion oral care composition and method for maintaining anticaries activity |
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