CN107496318A - A kind of desensitizing toothpaste of American-cockroach-extract-containing - Google Patents
A kind of desensitizing toothpaste of American-cockroach-extract-containing Download PDFInfo
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The present invention provides a kind of desensitizing toothpaste of American-cockroach-extract-containing, it is characterised in that is made up of the component of following masses percentage：Aluminium hydroxide 45.0%-55.0%, polyethylene glycol 400 20.0%-38.0%, glue 1.0%-2.0%, Aspartame 0-2.0%, foaming agent 2.0%-4.5%, potassium sorbate 0.02%, essence 0-0.3%, strontium chloride 0-1.0%, Radix Zanthoxyli extract 0.5%, sodium chloride 0.8%, American-cockroach-extract 0.5%-3.0%, deionized water surplus, said components sum are 100%.Make full use of antibacterial possessed by American-cockroach-extract, analgesia, antiinflammatory action, aid in utilizing the strontium chloride of antiallergic sense again and Nerve conduction can be reduced, analgesia, the Radix Zanthoxyli extract of stable effect are played, capacity antacid, effectively prevention and the improvement dentine hypersensitivity problem of tooth can be improved.
Description
Technical field
The present invention relates to a kind of desensitizing toothpaste, more particularly to a kind of desensitizing toothpaste and its system containing American-cockroach-extract
Preparation Method, belong to oral cleaning nursing article technical field.
Background technology
In recent years, the reinforcement of the improvement of people's living standards and government's communication and education, the oral health meaning of people is improved
Know.Although the oral health emphasis in many places comes up from the prevention that mouth disease is transferred to based on emergency treatment, but still
The adult for having large scale is perplexed by oral problem, including carious tooth, gingivitis, periodontitis, hypersensitive dentin, oral peculiar smell and
Dna exogenous pigment calmness etc..Another common odontopathy related to carious tooth and periodontitis is dentine hypersensitivity.It is mainly shown as tooth
By environmental stimuli as hot and cold, sour, sweet tea, machinery etc. stimulate when caused by of short duration, rapid and sharp ache.Dentine hypersensitivity
It is not a kind of independent disease, but the symptom that various dental diseases are shared, every enamel integrality that can destroy make dentine
Exposed various dental diseases, which include abrasion, acid etching, dental caries, gingival recession, periodontal treatment etc., can occur dentine hypersensitivity.Mesh
The sensitive definite pathogenesis of predentin there is no final conclusion.Epidemiology survey is shown：The people that China there are about 29.7% has difference
The dentine hypersensitivity problem of degree, the consumer that the whole world there are about 57% are perplexed by dentine hypersensitivity deeply.As generally existing
Make us the disease of puzzlement, it is treated but not enough fully and successfully, larger uncertainty also be present.Its treatment method is roughly divided into
Close dentinal tubule and the major class of calm Intradental nerve two.Desensitizing toothpaste economical and effective, it is currently used for treating dentine hypersensitivity
The most commonly used treatment method.Therefore, the toothpaste of research and development preventing and treating hyperesthesia of dentin is very necessary.
American cockroach Periplaneta americana L. are Insecta Pterigota Blattaria Blattidae Periplaneta elder brother
Worm, it is one of three advantages worm kind of blattaria.Its extract have anti-inflammatory, antibacterial, alleviation because of caused by dentine hypersensitivity pain,
The effect of promotion organization reparation.Having correlative study person to demonstrate American-cockroach-extract with hot plate method in mice analgesic test has significantly
Analgesic activity.
Radix zanthoxyli Zanthoxylum nitidum (Roxb.) are the dry root of rutaceae Radix zanthoxyli.Bitter, pungent, property
It is flat.There is narcotic analgesic, activating blood circulation and reducing swelling, clearing and activating the channels and collaterals.Alkaloid therein directly acts on dentine nerve endings, drop
Low neural conduction function, analgesia, stable effect are played, mitigates patient symptom to a certain extent.Volatile oil component one therein
Part makes the solidification denaturation of dentine internal protein, is covered in dentin surface；A part is penetrated into dentinal tubule, makes tubule
Diameter reduce and even close, reduce the permeability of dentine.In addition, anti-inflammatory antipathogenic composition therein can also suppress bacterial plaque and
The generation of periodontitis.
The content of the invention
It is an object of the invention to provide it is a kind of have to dentine hypersensitivity good prevention effect and can anti-inflammatory toothpaste and its
Preparation method.
To reach this purpose, the technical solution adopted by the present invention is：A kind of desensitizing toothpaste of American-cockroach-extract-containing,
It is characterized in that it is made up of the component of following masses percentage：Aluminium hydroxide 45.0% -55.0%, polyethylene glycol 400
20.0%-38.0%, glue 1.0%-2.0%, Aspartame 0-2.0%, foaming agent 2.0%-4.5%, potassium sorbate
0.02%, essence 0-0.3%, strontium chloride 0-1.0%, Radix Zanthoxyli extract 0.5%, sodium chloride 0.8%, American cockroach extraction
Thing 0.5% -3.0%, deionized water surplus, said components sum are 100%.
Described glue is sodium carboxymethylcellulose and carragheen, and both mass ratioes are：Sodium carboxymethylcellulose:Carragheen
=2:1；
Described foaming agent is lauryl sodium sulfate and sodium lauroyl sarcosine, and both mass ratioes are：Dodecyl
Sodium sulphate:Sodium lauroyl sarcosine=2:1.
The essence is lilac compound, is made into by following component：Caryophyllus oil 35.9%, peppermint oil 7.0%, eucalyptus oil
15.0%, fennel oil 24.0%, spearmint oil 15.0%, cinnamon oil 3.0%, vanillic aldehyde 0.1%.
The optimal manufacture craft of toothpaste of the invention is as follows：
1) weighs raw material by prescription quality fraction；
2) mixes standby sodium carboxymethylcellulose, carragheen, polyethylene glycol 400, adds deionized water mixing
Afterwards, after being heated to 80-90 DEG C, 10-20min is kept, sodium carboxymethylcellulose, carragheen is fully expanded, is cooled to afterwards
Room temperature, obtain mixed liquor；
3) sequentially adds Aspartame, potassium sorbate, strontium chloride, sodium chloride, Radix zanthoxyli in the mixed liquor of step 1)
Extract, lauryl sodium sulfate, sodium lauroyl sarcosine, aluminium hydroxide, are stirred, and obtain mixture；
4) adds American-cockroach-extract and essence in the mixture of step 2), after stirring 10-20min, stands old
Change 6h, obtain aged substance；
5) aged substance of step 3) is ground to after inspection do not measure grit thing by, be evacuated to vacuum not less than-
0.096MPa, it is filling, examine, obtain the desensitizing toothpaste of American-cockroach-extract-containing.
The American-cockroach-extract is as follows using semi-bionic extraction method：
1) after dry American cockroach polypide is crushed, it is put in flask, the mass concentration for adding 6 times of quality is 95%
Ethanol, 4h is handled at normal pressure, 50l DEG C of bath temperature, filtered, filter residue is put into baking oven, is dried in 50 DEG C to constant weight, obtains filter residue I；
2) three kinds of cushioning liquid that pH is respectively 2.0,7.5,8.3 are prepared with citric acid and disodium hydrogen phosphate, it is standby；
3) amount of 20ml cushioning liquid/g filter residues I is pressed, the cushioning liquid that pH is 2.0 is added in filter residue I, in normal pressure, water
1h is handled at 60 DEG C of bath temperature, is filtered, dried with the method for step 1), obtain filter residue II, filtrate I；
4) extracts filter residue II twice with the method for step 3) with the cushioning liquid that pH is 7.5,8.3 successively again, obtains filter residue
III, filtrate II, filter residue IV, filtrate III；
5) merging filtrates I, II, III, is evaporated under reduced pressure that be concentrated into can also at vacuum -0.04MPa, 70 DEG C of bath temperature
Evaporating dish is poured into during flowing, in 80 DEG C of oven dryings to constant weight, produces the American-cockroach-extract of semi-bionic extraction method.
The American-cockroach-extract extracted by this method, it is left special different to eliminate cockroach in general extraction methods
Taste, and the active ingredient of American cockroach is remained to greatest extent, hence it is evident that improve its subjective feeling in the application.
By Radix zanthoxyli pulverizing medicinal materials into 3 μm or so of fine powder；By the amount of 5ml solvents/g medicinal material powders, added in medicinal material powder
The solvent of following masses fraction：The hydrochloric acid solution of 75% ethanol+0.3%, the extraction of micro-boiling condensing reflux is heated to, is poured out after 2.5h
First time extract solution；The amount of 5ml solvents/g medicinal material powders is pressed again, continues to add same solvent in medicinal material, in the same way
Second is carried out to extract；Merge extract solution twice, be concentrated in vacuo at 50 DEG C with crude drug identical amount, produce Radix zanthoxyli and carry
Take thing.
The present invention has following advantages and effect：Using such scheme, make full use of possessed by American-cockroach-extract
Antibacterial, analgesia, antiinflammatory action, then aid in utilizing the strontium chloride of antiallergic sense and Nerve conduction can be reduced, play analgesia, peace
Tailor-made Radix Zanthoxyli extract, capacity antacid, effectively prevention and the improvement dentine hypersensitivity problem of tooth can be improved.
Embodiment
To further illustrate technical scheme, it is described in further details below by embodiment.
Liquid component used in the present invention, is not particularly illustrated, and is technical grade product purchased in market.
Fixation component used in the present invention, is not particularly illustrated, and is technical grade product purchased in market.
American-cockroach-extract as described below is as follows using semi-bionic extraction method：
1) dry American cockroach polypide is crushed with plant pulverizer, weighs 100g in pear-shaped flask, add 6 times of quality
Mass concentration be 95% ethanol, handle 4h at normal pressure, 50l DEG C of bath temperature, filter, filter residue is put into baking oven, in 50 DEG C
Dry to constant weight, obtain filter residue I；
2) 3 kinds of cushioning liquid are prepared with citric acid and disodium hydrogen phosphate, pH is respectively 2.0,7.5,8.3, standby；
3) 10g of filter residue I is weighed, the cushioning liquid that 200ml pH are 2.0 is added, is handled at normal pressure, 60 DEG C of bath temperature
1h, filtered, dried with the method for step 1), obtain filter residue II, filtrate I；
4) filter residue II is extracted twice with the cushioning liquid that pH is 7.5,8.3 successively again with the method for step 3), obtains filter residue
III, filtrate II, filter residue IV, filtrate III；
5) merging filtrate I, II, III, it is evaporated under reduced pressure at vacuum -0.04MPa, 70 DEG C of bath temperature and is concentrated into and can also flow
Evaporating dish is poured into when dynamic, in 80 DEG C of oven dryings to constant weight, produces the American-cockroach-extract of semi-bionic extraction method.
The extracting method of Radix Zanthoxyli extract as described below is as follows：By Radix zanthoxyli pulverizing medicinal materials into 3 μm or so of fine powder；Claim
10.00g is taken, is placed in 100ml volumetric flasks, adds the solvent for the following masses fraction that 50ml is prepared：The salt of 75% ethanol+0.3%
Acid solution, the extraction of micro-boiling condensing reflux is heated to, first time extract solution is poured out to obtain after 2.5h；Same solvent is added in medicinal material
50ml, carry out second by same technique and extract；Merge extract solution twice；The liquid of merging is concentrated in vacuo at 50 DEG C and carried
Take liquid:Medicinal material=1:1 mass ratio, produces Radix Zanthoxyli extract.
Essence as described below is lilac compound, is made into by following component：Caryophyllus oil 35.9%, peppermint oil 7.0%, eucalyptus oil
15.0%, fennel oil 24.0%, spearmint oil 15.0%, cinnamon oil 3.0%, vanillic aldehyde 0.1%.
Embodiment 1
Stocked up by following mass ratio：
Aluminium hydroxide 42.0%, polyethylene glycol 400 24.0%, sodium carboxymethylcellulose 0.8%, carragheen 0.4%, Ah
This Ba Tian 0.6%, lauryl sodium sulfate 2.0%, sodium lauroyl sarcosine 1.0%, potassium sorbate 0.02%, strontium chloride
1.0%, Radix Zanthoxyli extract 0.5%, sodium chloride 0.8%, American-cockroach-extract 1.0%, essence 0.3%, more than deionized water
Amount；
By following each step：
1) mixes above-mentioned standby sodium carboxymethylcellulose, carragheen, polyethylene glycol 400, adds deionized water and mixes
After even, after being heated to 80 DEG C, 20min kept, sodium carboxymethylcellulose, carragheen is fully expanded, is cooled to room temperature afterwards, obtain
Mixed liquor；
2) sequentially adds Aspartame, potassium sorbate, strontium chloride, sodium chloride, Radix zanthoxyli in the mixed liquor of step 1)
Extract, lauryl sodium sulfate, sodium lauroyl sarcosine, aluminium hydroxide, are stirred, and obtain mixture；
3) adds American-cockroach-extract and essence in the mixture of step 2), still aging after stirring 20min
6h, obtain aged substance；
4) aged substance of step 3) is ground to after inspection do not measure grit thing by, be evacuated to vacuum not less than-
0.096MPa, it is filling, examine, obtain the desensitizing toothpaste of American-cockroach-extract-containing.
Embodiment 2
Stocked up by following mass ratio：
Aluminium hydroxide 49.0%, polyethylene glycol 400 20.0%, sodium carboxymethylcellulose 0.7%, carragheen 0.35%, Ah
This Ba Tian 0.8%, lauryl sodium sulfate 1.5%, sodium lauroyl sarcosine 0.75%, potassium sorbate 0.02%, strontium chloride
1.0%, Radix Zanthoxyli extract 0.5%, sodium chloride 0.8%, American-cockroach-extract 1.5%, essence 0.3%, more than deionized water
Amount；
By following each step：
1) mixes above-mentioned standby sodium carboxymethylcellulose, carragheen, polyethylene glycol 400, adds deionized water and mixes
After even, after being heated to 90 DEG C, 10min kept, sodium carboxymethylcellulose, carragheen is fully expanded, is cooled to room temperature afterwards, obtain
Mixed liquor；
2) sequentially adds Aspartame, potassium sorbate, strontium chloride, sodium chloride, Radix zanthoxyli in the mixed liquor of step 1)
Extract, lauryl sodium sulfate, sodium lauroyl sarcosine, aluminium hydroxide, are stirred, and obtain mixture；
3) adds American-cockroach-extract and essence in the mixture of step 2), still aging after stirring 13min
6h, obtain aged substance；
4) aged substance of step 3) is ground to after inspection do not measure grit thing by, be evacuated to vacuum not less than-
0.096MPa, it is filling, examine, obtain the desensitizing toothpaste of American-cockroach-extract-containing.
Embodiment 3
Stocked up by following mass ratio：
Aluminium hydroxide 45.0%, polyethylene glycol 400 30.0%, sodium carboxymethylcellulose 1.0%, carragheen 0.5%, Ah
This Ba Tian 0.8%, lauryl sodium sulfate 1.8%, sodium lauroyl sarcosine 0.9%, potassium sorbate 0.02%, strontium chloride
1.0%, Radix Zanthoxyli extract 0.5%, sodium chloride 0.8%, American-cockroach-extract 2.0%, essence 0.2%, more than deionized water
Amount；
By following each step：
1) mixes above-mentioned standby sodium carboxymethylcellulose, carragheen, polyethylene glycol 400, adds deionized water and mixes
After even, after being heated to 85 DEG C, 15min kept, sodium carboxymethylcellulose, carragheen is fully expanded, is cooled to room temperature afterwards, obtain
Mixed liquor；
2) sequentially adds Aspartame, potassium sorbate, strontium chloride, sodium chloride, Radix zanthoxyli in the mixed liquor of step 1)
Extract, lauryl sodium sulfate, sodium lauroyl sarcosine, aluminium hydroxide, are stirred, and obtain mixture；
3) adds American-cockroach-extract and essence in the mixture of step 2), still aging after stirring 17min
6h, obtain aged substance；
4) aged substance of step 3) is ground to after inspection do not measure grit thing by, be evacuated to vacuum not less than-
0.096MPa, it is filling, examine, obtain the desensitizing toothpaste of American-cockroach-extract-containing.
Embodiment 4
Stocked up by following mass ratio：
Aluminium hydroxide 42.0%, polyethylene glycol 400 28.0%, sodium carboxymethylcellulose 1.0%, carragheen 0.5%, Ah
This Ba Tian 0.6%, lauryl sodium sulfate 2.0%, sodium lauroyl sarcosine 1.0%, potassium sorbate 0.02%, strontium chloride
1.0%, Radix Zanthoxyli extract 0.5%, sodium chloride 0.8%, American-cockroach-extract 2.5%, essence 0.2%, more than deionized water
Amount；
By following each step：
1) mixes above-mentioned standby sodium carboxymethylcellulose, carragheen, polyethylene glycol 400, adds deionized water and mixes
After even, after being heated to 87 DEG C, 14min kept, sodium carboxymethylcellulose, carragheen is fully expanded, is cooled to room temperature afterwards, obtain
Mixed liquor；
2) sequentially adds Aspartame, potassium sorbate, strontium chloride, sodium chloride, Radix zanthoxyli in the mixed liquor of step 1)
Extract, lauryl sodium sulfate, sodium lauroyl sarcosine, aluminium hydroxide, are stirred, and obtain mixture；
3) adds American-cockroach-extract and essence in the mixture of step 2), still aging after stirring 15min
6h, obtain aged substance；
4) aged substance of step 3) is ground to after inspection do not measure grit thing by, be evacuated to vacuum not less than-
0.096MPa, it is filling, examine, obtain the desensitizing toothpaste of American-cockroach-extract-containing.
Embodiment 5
Stocked up by following mass ratio：
Aluminium hydroxide 44.0%, polyethylene glycol 400 32.0%, sodium carboxymethylcellulose 1.2%, carragheen 0.6%, ten
Sodium dialkyl sulfate 2.0%, sodium lauroyl sarcosine 1.0%, potassium sorbate 0.02%, strontium chloride 1.0%, Radix Zanthoxyli extract
0.5%, sodium chloride 0.8%, American-cockroach-extract 3.0%, deionized water surplus.
By following each step：
1) mixes above-mentioned standby sodium carboxymethylcellulose, carragheen, polyethylene glycol 400, adds deionized water and mixes
After even, after being heated to 82 DEG C, 17min kept, sodium carboxymethylcellulose, carragheen is fully expanded, is cooled to room temperature afterwards, obtain
Mixed liquor；
2) sequentially adds potassium sorbate, strontium chloride, sodium chloride, Radix Zanthoxyli extract, ten in the mixed liquor of step 1)
Sodium dialkyl sulfate, sodium lauroyl sarcosine, aluminium hydroxide, are stirred, and obtain mixture；
3) adds American-cockroach-extract in the mixture of step 2), after stirring 19min, still aging 6h, obtains old
Compound；
4) aged substance of step 3) is ground to after inspection do not measure grit thing by, be evacuated to vacuum not less than-
0.096MPa, it is filling, examine, obtain the desensitizing toothpaste of American-cockroach-extract-containing.
Embodiment 6
Stocked up by following mass ratio：
Aluminium hydroxide 46.0%, polyethylene glycol 400 30.0%, sodium carboxymethylcellulose 1.5%, carragheen 0.75%, ten
Sodium dialkyl sulfate 2.0%, sodium lauroyl sarcosine 1.0%, potassium sorbate 0.02%, Radix Zanthoxyli extract 0.5%, sodium chloride
0.8%, American-cockroach-extract 3.2%, deionized water surplus.
By following each step：
1) mixes above-mentioned standby sodium carboxymethylcellulose, carragheen, polyethylene glycol 400, adds deionized water and mixes
After even, after being heated to 88 DEG C, 12min kept, sodium carboxymethylcellulose, carragheen is fully expanded, is cooled to room temperature afterwards, obtain
Mixed liquor；
2) sequentially adds potassium sorbate, sodium chloride, Radix Zanthoxyli extract, dodecyl sulphur in the mixed liquor of step 1)
Sour sodium, sodium lauroyl sarcosine, aluminium hydroxide, are stirred, and obtain mixture；
3) adds American-cockroach-extract in the mixture of step 2), after stirring 11min, still aging 6h, obtains old
Compound；
4) aged substance of step 3) is ground to after inspection do not measure grit thing by, be evacuated to vacuum not less than-
0.096MPa, it is filling, examine, obtain the desensitizing toothpaste of American-cockroach-extract-containing.
The toothpaste described in embodiment 1-6 prepared using the above method can prevent and improve dentine hypersensitivity, have very well
Anti- dentine hypersensitivity, antibacterial, analgesic effect.
Test example：
First, anti-sensitization test
1) subjects
The sample population 50 of adult's dentine hypersensitivity epidemiology survey.
2) inclusive criterias
1. 20-60 years old ages；
2. the voluntary participation experiment of 8 weeks by a definite date；
3. overall health of patients is good, non-pregnant woman or women breast-feeding their children；
4. to commercial oral product without allergies；In a length of 100mm pre-sifted numerical pain judges (VAS) scale,
The subjective feeling of patient " daily " odonthemodia must be in the range of 10-90mm；
5. patient's at least 2 teeth are blown to cold air stimulates sensitivity, and is marked in a length of 100mm cold stimulation sensitivity VAS
In chi, the subjective feeling of subject's odonthemodia is in the range of 30-80；The position of tested odontogenesis dentine hypersensitivity is buccal surface tooth
Neck, and by visual examination or visit and examine and can clearly judge that suffering from tooth has dentine exposure；
6. tested tooth is labial teeth or premolar teeth；
7. tested tooth splits, without pulp inflammation shape without dental caries, without obturation, without odontagma, without hidden；Movable degree≤1 degree；
8. excluding 1 month used anticonvulsive drug, antidepressants, sedative and sedative person for oral administration before experiment, taken in 1 week
Cross antiphlogistic, anodyne person.
3) test methods
1. primary dcreening operation
Every subject for meeting inclusive criteria, any quadrant, non-adjacent 2 teeth may be selected as tested tooth, according to
Screening criteria records the assessment result of subject and the tooth position of evaluation in primary dcreening operation table.
Ordinary toothpaste and one of the qualified subject without desensitization composition is issued to use fur Toothbrush for adult 2 weeks.This 2
In the elution phase in week, it is desirable to which subject uses the toothpaste and toothbrush, 2 times a day, every time no less than 2min.
2. baseline visit
Two weeks subjective feelings come dentine hypersensitivity pain are assessed with VAS methods after 2 weeks, score value is less than 10mm or higher than 90mm
Person must still exclude.Assessed using VAS and record 2 VAS for including tooth values, operation specific method is consistent when will be with primary dcreening operation.If
Patient is qualified by inspection tooth in the absence of at least 2, then excludes this patient.
Using subject as research unit, include tooth for 2 and carry out VAS scorings respectively, the VAS of 2 teeth of every subject is averaged
It is worth the VAS values for subject.
Random packet：Baseline inspection or selected subject are divided into test group according to sex and age group stratified random
And control group.
Test group：Toothpaste containing American-cockroach-extract prepared by embodiment 3-6；
Control group：Ordinary toothpaste without functional component.
3. 4 weeks, 8 weeks access
After specified toothpaste, toothbrush 4 weeks and 8 weeks, subject is paid a return visit, subject's tooth sheet is assessed using VAS again
The subjective feeling of matter sensitivity pain, oral soft tissue inspection and the sensitive inspection of cold air injection, checking step are carried out by examiner
It is consistent during with method with baseline, it is desirable to which subject forbids any oral hygiene measures or chew gum, 2h before access in 4h
Interior fasting, prohibit water.
4. statistical procedures
Statistical analysis is carried out using SPSS softwares.During with independent samples t test comparative test group and control group baseline
Difference between the VAS value changes of VAS values, test group and control group after intervention, P ＜ 0.05 think that difference has statistics meaning
Justice.
4) result of the tests
48 subjects are included during baseline, wherein 3 during research because flu takes antibiotic, 4 to receive filling quick
Feel the dental care of tooth, these do not meet inclusive criteria.It is respectively 32 and 9 finally to include the test group of analysis and control group
Name, 32 are divided into four groups, respectively with the toothpaste of the embodiment of the present invention 3-6, respectively use once sooner or later for each person every day.Two groups by
The change such as following table of examination person's sensitive VAS values during research.Show that test group subject is quick from baseline to cold stimulation at 4 weeks in table
Sense VAS averages reduce degree (1.02) and are significantly higher than control group (0.34), and difference is statistically significant.Test group subject is from base
Line reduces degree (1.58) to subjective sensitive VAS averages at 8 weeks and is significantly higher than control group (0.23), and difference is statistically significant.
5) experiment conclusions
The toothpaste plays the role of good antiallergic sense.
2nd, bacteriostatic test
The toothpaste containing American-cockroach-extract prepared with embodiment 3-6 acts on porphyromonas gingivalis, white is read
Pearl bacterium, Streptococcus mutans, staphylococcus aureus, Escherichia coli and Bacillus acidi lactici are as test group, not add functional component
Blank toothpaste is as a control group.
1) subjects：Purchase the porphyromonas gingivalis in Institute of Micro-biology of Yunnan University, Candida albicans, variation chain
Coccus, staphylococcus aureus, Escherichia coli and Bacillus acidi lactici.
2) test procedures：Zengjing Granule is first carried out, be then respectively adding the preparation of 1g embodiments 3-6 contains American cockroach
The toothpaste of extract and the control toothpaste for being not added with functional component, the oscillation action through 2min, the number of bacterium before and after detection contrast
Amount.
3) result of the tests：After testing, the bacteriostasis property of toothpaste is up to 91.1%, experimental result such as following table：
4) conclusion (of pressure testing)s：Toothpaste containing American-cockroach-extract prepared by embodiment 3-6 acts on porphyromonas list
The sterilizing rate of born of the same parents bacterium, Streptococcus mutans and Bacillus acidi lactici is up to 91.1%, illustrates that the toothpaste has good fungistatic effect.
Claims (7)
1. a kind of desensitizing toothpaste of American-cockroach-extract-containing, it is characterised in that be made up of the component of following masses percentage：Hydrogen
Aluminum oxide 45.0%-55.0%, polyethylene glycol 400 20.0%-38.0%, glue 1.0%-2.0%, Aspartame 0-2.0%, foaming
Agent 2.0%-4.5%, potassium sorbate 0.02%, essence 0-0.3%, strontium chloride 0-1.0%, Radix Zanthoxyli extract 0.5%, sodium chloride
0.8%, American-cockroach-extract 0.5% -3.0%, deionized water surplus, said components sum is 100%.
2. the desensitizing toothpaste of American-cockroach-extract-containing as claimed in claim 1, it is characterised in that described glue is carboxymethyl
Sodium cellulosate and carragheen, both mass ratioes are：Sodium carboxymethylcellulose:Carragheen=2:1.
3. the desensitizing toothpaste of American-cockroach-extract-containing as claimed in claim 1, it is characterised in that described foaming agent is ten
Sodium dialkyl sulfate and sodium lauroyl sarcosine, both mass ratioes are：Lauryl sodium sulfate:Sodium lauroyl sarcosine=2:
1。
4. the desensitizing toothpaste of American-cockroach-extract-containing as claimed in claim 1, it is characterised in that the essence is that cloves is fragrant
Essence, it is made into by following component：Caryophyllus oil 35.9%, peppermint oil 7.0%, eucalyptus oil 15.0%, fennel oil 24.0%, spearmint oil
15.0%, cinnamon oil 3.0%, vanillic aldehyde 0.1%.
5. the desensitizing toothpaste of American-cockroach-extract-containing as claimed in claim 1, it is characterised in that be made by following steps：
1）Raw material is weighed by following mass fraction：
Aluminium hydroxide 45.0%-55.0%, polyethylene glycol 400 20.0%-38.0%, glue 1.0%-2.0%, Aspartame 0-
2.0%, foaming agent 2.0%-4.5%, potassium sorbate 0.02%, essence 0-0.3%, strontium chloride 0-1.0%, Radix Zanthoxyli extract
0.5%, sodium chloride 0.8%, American-cockroach-extract 0.5% -3.0%, deionized water surplus, said components sum is 100%；
2）Standby sodium carboxymethylcellulose, carragheen, polyethylene glycol 400 are mixed, after adding deionized water mixing, added
After hot to 80-90 DEG C, 10-20 min are kept, sodium carboxymethylcellulose, carragheen is fully expanded, is cooled to room afterwards
Temperature, obtain mixed liquor；
3）In step 1）Mixed liquor in, sequentially add Aspartame, potassium sorbate, strontium chloride, sodium chloride, Radix zanthoxyli extraction
Thing, lauryl sodium sulfate, sodium lauroyl sarcosine, aluminium hydroxide, are stirred, and obtain mixture；
4）In step 2）Mixture in, add American-cockroach-extract and essence, it is still aging after stirring 10-20 min
6 h, obtain aged substance；
5）By step 3）Aged substance be ground to after inspection do not measure grit thing, be evacuated to vacuum not less than -0.096
MPa, it is filling, examine, obtain the desensitizing toothpaste of American-cockroach-extract-containing.
6. the desensitizing toothpaste of American-cockroach-extract-containing as claimed in claim 1, it is characterised in that the American cockroach extraction
Thing extracts with the following method：
1）Dry American cockroach polypide is crushed, the mass concentration for adding 6 times of amounts of American cockroach worm silty amount is 95% second
Alcohol, 4 h are handled at normal pressure, 50l DEG C of bath temperature, filtered, filter residue is put into baking oven, is dried in 50 DEG C to constant weight, obtains filter residue I；
2）Three kinds of cushioning liquid that pH is respectively 2.0,7.5,8.3 are prepared with citric acid and disodium hydrogen phosphate, it is standby；
3）By the amount of 20 ml cushioning liquid/g filter residues I, the cushioning liquid that pH is 2.0 is added in filter residue I, in normal pressure, water-bath temperature
1 h is handled at 60 DEG C of degree, with step 1）Method filtering, dry, obtain filter residue II, filtrate I；
4）Filter residue II is pressed into step 3）It is described to be extracted twice with the cushioning liquid that pH is 7.5,8.3 successively, obtain filter residue III, filtrate
II, filter residue IV, filtrate III；
5）Merging filtrate I, II, III, it is evaporated under reduced pressure at the MPa of vacuum -0.04,70 DEG C of bath temperature and is concentrated into and can also flow
Evaporating dish is poured into when dynamic, in 80 DEG C of oven dryings to constant weight, produces American-cockroach-extract.
7. the desensitizing toothpaste of American-cockroach-extract-containing as claimed in claim 1, it is characterised in that the Radix Zanthoxyli extract
Extracting method it is as follows：By Radix zanthoxyli pulverizing medicinal materials into 3 μm or so of fine powder；By the amount of 5 ml solvents/g medicinal material powders, in medicinal material
The solvent of following masses fraction is added in powder：The hydrochloric acid solution of 75% ethanol+0.3%, it is heated to the extraction of micro-boiling condensing reflux, 2.5 h
After pour out to obtain first time extract solution；The amount of 5 ml solvents/g medicinal material powders is pressed again, continues to add same solvent in medicinal material, by same
The method of sample carries out second and extracted；Merge extract solution twice, be concentrated in vacuo at 50 DEG C with crude drug identical amount, i.e.,
Obtain Radix Zanthoxyli extract.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107970199A (en) * | 2018-01-03 | 2018-05-01 | 昆明赛诺制药股份有限公司 | A kind of toothpaste of the extract containing American cockroach |
| CN112569154A (en) * | 2020-12-30 | 2021-03-30 | 柳州两面针股份有限公司 | Plant antibacterial oral care product |
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| CN101829032A (en) * | 2010-05-11 | 2010-09-15 | 李少君 | Dual-purpose toothpaste composition and preparation method thereof |
| CN104188855A (en) * | 2014-08-20 | 2014-12-10 | 广州立白企业集团有限公司 | Traditional Chinese medicine toothpaste with effects of preventing and relieving tooth sensitivity |
| CN105476947A (en) * | 2015-12-28 | 2016-04-13 | 昆明东特农业科技有限公司 | Toothpaste containing periplaneta Americana and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101829032A (en) * | 2010-05-11 | 2010-09-15 | 李少君 | Dual-purpose toothpaste composition and preparation method thereof |
| CN104188855A (en) * | 2014-08-20 | 2014-12-10 | 广州立白企业集团有限公司 | Traditional Chinese medicine toothpaste with effects of preventing and relieving tooth sensitivity |
| CN105476947A (en) * | 2015-12-28 | 2016-04-13 | 昆明东特农业科技有限公司 | Toothpaste containing periplaneta Americana and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107970199A (en) * | 2018-01-03 | 2018-05-01 | 昆明赛诺制药股份有限公司 | A kind of toothpaste of the extract containing American cockroach |
| CN112569154A (en) * | 2020-12-30 | 2021-03-30 | 柳州两面针股份有限公司 | Plant antibacterial oral care product |
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Application publication date: 20171222 |