CN113831407B - 用于使用多个引导rna来破坏免疫耐受性的方法 - Google Patents

用于使用多个引导rna来破坏免疫耐受性的方法 Download PDF

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CN113831407B
CN113831407B CN202111158680.6A CN202111158680A CN113831407B CN 113831407 B CN113831407 B CN 113831407B CN 202111158680 A CN202111158680 A CN 202111158680A CN 113831407 B CN113831407 B CN 113831407B
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mouse
sequence
human
target
guide rna
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CN113831407A (zh
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维拉·沃罗宁那
林恩·麦克唐纳
马林·普里塞特
卡曼·维纳斯·莱
阿肖克·巴迪斯
安德鲁·J.·莫菲
古斯塔沃·德罗格特
大卫·佛伦杜威
布莱恩·扎姆布罗维兹
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Regeneron Pharmaceuticals Inc
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CN202111158680.6A 2016-05-20 2017-05-19 用于使用多个引导rna来破坏免疫耐受性的方法 Active CN113831407B (zh)

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US201662339472P 2016-05-20 2016-05-20
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PCT/US2017/033648 WO2017201476A1 (en) 2016-05-20 2017-05-19 Methods for breaking immunological tolerance using multiple guide rnas
CN202111158680.6A CN113831407B (zh) 2016-05-20 2017-05-19 用于使用多个引导rna来破坏免疫耐受性的方法
CN201780044071.3A CN109475109B (zh) 2016-05-20 2017-05-19 用于使用多个引导rna来破坏免疫耐受性的方法

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US10323236B2 (en) 2011-07-22 2019-06-18 President And Fellows Of Harvard College Evaluation and improvement of nuclease cleavage specificity
US9163284B2 (en) 2013-08-09 2015-10-20 President And Fellows Of Harvard College Methods for identifying a target site of a Cas9 nuclease
US9359599B2 (en) 2013-08-22 2016-06-07 President And Fellows Of Harvard College Engineered transcription activator-like effector (TALE) domains and uses thereof
US9526784B2 (en) 2013-09-06 2016-12-27 President And Fellows Of Harvard College Delivery system for functional nucleases
US9228207B2 (en) 2013-09-06 2016-01-05 President And Fellows Of Harvard College Switchable gRNAs comprising aptamers
US9322037B2 (en) 2013-09-06 2016-04-26 President And Fellows Of Harvard College Cas9-FokI fusion proteins and uses thereof
US20150165054A1 (en) 2013-12-12 2015-06-18 President And Fellows Of Harvard College Methods for correcting caspase-9 point mutations
US10077453B2 (en) 2014-07-30 2018-09-18 President And Fellows Of Harvard College CAS9 proteins including ligand-dependent inteins
KR102531016B1 (ko) 2014-11-21 2023-05-10 리제너론 파마슈티칼스 인코포레이티드 쌍 형성된 가이드 rna를 사용하는 표적화된 유전자 변형을 위한 방법 및 조성물
IL310721B2 (en) 2015-10-23 2025-11-01 Harvard College Nucleobase editors and uses thereof
CN113831407B (zh) 2016-05-20 2024-06-11 瑞泽恩制药公司 用于使用多个引导rna来破坏免疫耐受性的方法
CN110214183A (zh) 2016-08-03 2019-09-06 哈佛大学的校长及成员们 腺苷核碱基编辑器及其用途
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