BR112018073750A2 - métodos para gerar proteínas de ligação ao antígeno contra um antígeno estranho de interesse e para produzir um animal não humano geneticamente modificado com tolerância reduzida de um antígeno estranho de interesse - Google Patents

métodos para gerar proteínas de ligação ao antígeno contra um antígeno estranho de interesse e para produzir um animal não humano geneticamente modificado com tolerância reduzida de um antígeno estranho de interesse

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Publication number
BR112018073750A2
BR112018073750A2 BR112018073750-0A BR112018073750A BR112018073750A2 BR 112018073750 A2 BR112018073750 A2 BR 112018073750A2 BR 112018073750 A BR112018073750 A BR 112018073750A BR 112018073750 A2 BR112018073750 A2 BR 112018073750A2
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Brazil
Prior art keywords
interest
antigen
foreign antigen
methods
producing
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BR112018073750-0A
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English (en)
Inventor
Voronina Vera
Macdonald Lynn
Prissette Marine
Venus Lai Ka-Man
Badithe Ashok
J. Murphy Andrew
Droguett Gustavo
Frendewey David
Zambrowicz Brian
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Regeneron Pharmaceuticals, Inc.
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Publication of BR112018073750A2 publication Critical patent/BR112018073750A2/pt

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Abstract

os métodos e composições são fornecidos para produzir animais não humanos com tolerância reduzida de um antígeno estranho de interesse e produzir proteínas de ligação ao antígeno contra esse antígeno estranho de interesse utilizando estes animais. os métodos e composições empregam sistemas crispr/cas9 usando múltiplos rnas guia para reduzir ou eliminar a expressão de um autoantígeno homólogo ou compartilhar um epítopo de interesse com o antígeno estranho de interesse ou para reduzir ou eliminar a expressão de um epítopo no autoantígeno que é compartilhado com o antígeno estranho de interesse.
BR112018073750-0A 2016-05-20 2017-05-19 métodos para gerar proteínas de ligação ao antígeno contra um antígeno estranho de interesse e para produzir um animal não humano geneticamente modificado com tolerância reduzida de um antígeno estranho de interesse BR112018073750A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662339472P 2016-05-20 2016-05-20
US62/339,472 2016-05-20
US201662368604P 2016-07-29 2016-07-29
US62/368,604 2016-07-29
PCT/US2017/033648 WO2017201476A1 (en) 2016-05-20 2017-05-19 Methods for breaking immunological tolerance using multiple guide rnas

Publications (1)

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BR112018073750A2 true BR112018073750A2 (pt) 2019-02-26

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US (2) US20170332610A1 (pt)
EP (2) EP4368637A2 (pt)
JP (2) JP7324583B2 (pt)
KR (2) KR102356542B1 (pt)
CN (2) CN109475109B (pt)
AU (2) AU2017268458B2 (pt)
BR (1) BR112018073750A2 (pt)
CA (1) CA3022997C (pt)
IL (1) IL262888A (pt)
MX (1) MX2018014172A (pt)
NZ (1) NZ747857A (pt)
RU (2) RU2745563C2 (pt)
SG (2) SG11201809552SA (pt)
WO (1) WO2017201476A1 (pt)

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