CN113813319A - Medicine for treating bee venom and preparation method thereof - Google Patents

Medicine for treating bee venom and preparation method thereof Download PDF

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CN113813319A
CN113813319A CN202111164924.1A CN202111164924A CN113813319A CN 113813319 A CN113813319 A CN 113813319A CN 202111164924 A CN202111164924 A CN 202111164924A CN 113813319 A CN113813319 A CN 113813319A
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medicine
bee venom
arrowhead
treating
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林加城
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/884Alismataceae (Water-plantain family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11Pteridophyta or Filicophyta (ferns)
    • A61K36/12Filicopsida or Pteridopsida
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/78Saururaceae (Lizard's-tail family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/31Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Biotechnology (AREA)
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  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention relates to the field of traditional Chinese medicine compositions, in particular to a medicine for treating bee venom and a preparation method thereof, wherein the medicine comprises the following raw materials in parts by weight: 10-20 parts of arrowhead, 10-20 parts of ramie leaf, 10-20 parts of houttuynia cordata and 5-10 parts of paris polyphylla. In the invention, the Chinese medicinal materials are matched with each other, so that the traditional Chinese medicine composition has the effects of clearing heat and removing toxicity, reducing the concentration of bee venom, improving the removal speed of the toxin, and relieving swelling and pain, can quickly relieve pain for patients, and relieves discomfort of the patients.

Description

Medicine for treating bee venom and preparation method thereof
Technical Field
The invention relates to the field of traditional Chinese medicine compositions, and particularly relates to a medicine for treating bee venom and a preparation method thereof.
Background
The bee venom mainly contains histamine, formic acid, neurotoxic component, etc. and is a kind of toxic toxin. When a human or an animal is stinged by bees, symptoms such as hemolysis, bleeding, central nervous system inhibition and toxic liver disease can be caused; in severe cases, multiple organ failure can occur, leading to death.
At present, the Western medicine for treating bee venom is orally taken with chlorpheniramine maleate, diphenhydramine and other medicines, and the curative effect of the medicines is not obvious; the external medicine mainly comprises acyclovir, dermatitis healing cream and the like, and is mainly applied locally to the injured skin, but the long-term local application can cause allergy, contact dermatitis and the like and also has larger side effect; the main injection drugs include adrenalin, pressor, hormone and the like, and the drugs have large side effects and can cause drug resistance after being applied in large quantities for a long time.
The traditional Chinese medicines such as purslane, polygonum hydropiper root, wild taro, ginger and honeycomb are adopted to treat bee venom, and the bee venom has a certain treatment effect, but has the problems of unobvious effect, susceptibility to wound inflammation, poor pain relieving effect and the like.
Disclosure of Invention
The invention aims to provide a medicine for treating bee venom, which contains arrowheads, ramie leaves and houttuynia cordata, wherein the arrowheads have the effects of clearing heat, promoting urination and detoxifying, the ramie leaves have the effect of stopping bleeding and detoxifying, and the houttuynia cordata has the effect of clearing heat and detoxifying, and the three are matched with each other, so that the medicine has an excellent treatment effect on the bee venom.
The invention also aims to provide a preparation method of the medicine for treating bee venom, which takes fresh arrowhead, ramie leaves, houttuynia cordata and paris polyphylla as raw materials, directly extracts cell sap in the raw materials by adopting a pressing mode, protects the effective components and the drug effect of the raw materials to the maximum extent, and improves the treatment effect of the medicine on bee venom.
The technical problem to be solved by the invention is realized by adopting the following technical scheme.
On one hand, the embodiment of the invention provides a medicament for treating bee venom, which comprises the following raw materials in parts by weight: 10-20 parts of arrowhead, 10-20 parts of ramie leaf, 10-20 parts of houttuynia cordata and 5-10 parts of paris polyphylla.
The arrowhead has the effects of clearing heat, stopping bleeding, reducing swelling, resolving masses, detoxifying and the like. Can be used for treating cough, bloody sputum, hematemesis, etc. The arrowhead can be used for treating bite of dog, snake, etc. Cleaning rhizoma Sagittariae Sagittifoliae, pounding, adding small amount of rhizoma Zingiberis recens juice, mixing, and applying to treat toxic swelling or soft tissue, red swelling and pain.
The ramie leaves refer to the leaves of ramie, and fresh ramie leaves contain lutein, alpha-carotene, beta-carotene, rutin, rhoifolin and the like, have the effects of cooling blood, stopping bleeding, dissipating blood stasis, relieving swelling and detoxifying, and have the effects of relieving pain, clearing heat and detoxifying for bee venom.
The cordate houttuynia is pungent in flavor and cold in nature, can clear away heat and toxic materials, relieve swelling and suppuration, promote diuresis for treating stranguria, clear away heat and stop diarrhea, and strengthen stomach to promote digestion, and is used for treating lung abscess, sore and ulcer pyogenic infections, hemorrhoid hematochezia, accumulated heat in spleen and stomach and the like caused by excess heat, heat toxin, damp pathogen and disease heat.
Rhizoma Helminthostachydis Zeylanicae has effects of clearing heat and detoxicating, relieving swelling and pain, calming endogenous wind and cooling, and can be used for treating venomous snake, poisonous insect bite, pyocutaneous disease and pyogenic infections by external application.
In the invention, the four medicines are used in a compatible manner, and the composition can be coated on the skin where the bees sting, so that the pain can be quickly relieved, the toxin can be quickly removed, the discomfort of a patient can be relieved, the concentration of bee venom can be reduced, the toxin removing efficiency can be accelerated, and a good treatment effect can be achieved for the patient.
In some embodiments of the invention, 1-5 parts of dandelion may also be added. The dandelion has the effects of eliminating heat toxin, relieving food toxicity, eliminating swollen nuclei, treating furunculosis, acute mastitis and the like; through adding the dandelion, can improve the effect of relieving pain of medicine, in the use, the patient's discomfort is alleviated in the analgesia that can be quick for patient's comfort increases, and patient's mood is reconciled.
In another aspect, the embodiment of the present invention provides a method for preparing a medicine for treating bee venom, which comprises the following steps:
s1, selecting fresh arrowhead, ramie leaf, houttuynia cordata and paris polyphylla, cleaning, uniformly mixing, squeezing and collecting juice;
s2, selecting dandelion, cleaning, squeezing and collecting juice;
and S3, combining the juices in the step S1 and the step S2, and concentrating.
When the medicine is prepared, fresh arrowhead, ramie leaves, houttuynia cordata and paris polyphylla are selected as raw materials, effective components in the raw materials are obtained in a pressing mode, high-temperature volatilization of the effective components can be reduced, and the content of the effective components in juice is further improved.
Compared with the prior art, the embodiment of the invention has at least the following advantages or beneficial effects:
1. in the invention, the Chinese medicinal materials are matched with each other, so that the traditional Chinese medicine composition has the effects of clearing heat and removing toxicity, cooling blood and stopping bleeding, dissipating blood stasis and reducing swelling, reducing the concentration of bee venom, improving the removal speed of the toxin, also has the effect of relieving pain, can quickly relieve pain and detoxify for patients, and relieves discomfort of the patients.
2. In the invention, effective components are extracted from partial Chinese medicinal raw materials in a pressing mode, so that the loss of the effective components is reduced, and the effective components in the Chinese medicinal herbs can be maintained to the greatest extent.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
It should be noted that the embodiments and features of the embodiments may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.
The embodiment of the invention provides a medicament for treating bee venom, which comprises the following raw materials in parts by weight: 10-20 parts of arrowhead, 10-20 parts of ramie leaf, 10-20 parts of houttuynia cordata and 5-10 parts of paris polyphylla.
In some embodiments of the present invention, the composition comprises the following raw materials in parts by weight: 15 parts of arrowhead, 15 parts of ramie leaf, 15 parts of houttuynia cordata and 5 parts of paris polyphylla. In this embodiment, the amount of arrowhead, ramie leaf and houttuynia cordata is the same, and a small amount of paris polyphylla is matched, so that the treatment effect is good, the skin of the affected part is free from infection and inflammation after the use, and the treatment effect on mild patients is obvious.
In some embodiments of the present invention, the composition further comprises 1 to 5 parts by weight of dandelion. The dandelion has the effects of eliminating heat toxin, relieving food toxicity, eliminating swollen nuclei, treating furunculosis, acute mastitis and the like; through adding the dandelion, can improve the effect of relieving pain of medicine, in the use, the patient's discomfort is alleviated in the analgesia that can be quick for patient's comfort increases, and patient's mood is reconciled.
In some embodiments of the present invention, the composition comprises the following raw materials in parts by weight: 15 parts of arrowhead, 15 parts of ramie leaves, 15 parts of houttuynia cordata, 5 parts of paris polyphylla and 5 parts of dandelion. Through adding a small amount of dandelion, the dandelion has the effect of detumescence, and the cooperation of dandelion, arrowhead, ramie leaf and the like improves the detumescence and pain-relieving effects of the medicine, shortens the treatment time, and improves the treatment effect.
After the effective components in the raw materials of the traditional Chinese medicine are extracted, the traditional Chinese medicine can be prepared into different external preparations, such as spray, and the like, so as to be convenient for use in different occasions and different parts.
In some embodiments of the present invention, there is provided a method of preparing the above-described medicament, comprising the steps of: s1, selecting fresh arrowhead, ramie leaf, houttuynia cordata and paris polyphylla, cleaning, uniformly mixing, squeezing and collecting juice;
s2, selecting dandelion, cleaning, squeezing and collecting juice;
s3, combining the juices from step S1 and step S2 and step S2, and concentrating.
In the embodiment of the invention, fresh arrowhead, ramie leaves, houttuynia cordata and paris polyphylla are selected as raw materials, and effective components in the raw materials are obtained in a pressing mode, so that the effective components of the traditional Chinese medicinal materials are effectively maintained, the content of the effective components in the medicine is increased, and the efficacy of the medicine is further improved.
The features and properties of the present invention are described in further detail below with reference to examples.
Examples 1 to 5
The drugs of examples 1-5 were prepared as follows:
s1: preparing raw materials, cleaning fresh arrowhead, ramie leaves, houttuynia cordata and paris polyphylla, cutting, placing in a container, mixing uniformly, grinding and squeezing in the container, and collecting juice;
s2: weighing dandelion, cleaning, squeezing, filtering, and collecting juice;
s3: combining the juices of step S1 and step S2, and concentrating.
Wherein, the proportion of each raw material in examples 1-5 is shown in Table 1, and the weight of each component is Kg.
TABLE 1 proportioning of the raw materials of the drugs of examples 1-5
Figure BDA0003291374550000051
Figure BDA0003291374550000061
Comparative example
Comparative example 1: the difference from example 1 is that in comparative example 1, houttuynia cordata was not added, and the remaining components and the preparation method are the same as those of example 1.
Comparative example 2: except for the difference from example 1, in comparative example 2, no ramie leaf was added, and the remaining components and the preparation method were the same as those of example 1.
Comparative example 3: except for example 1, in comparative example 3, no arrowhead was added, and the remaining components and the preparation method were the same as those of example 1.
Comparative example 4: weighing 1Kg of purslane and 0.2Kg of ginger, grinding, filtering and collecting juice.
Examples of the experiments
Clinical experiments
Patient 1: for a female, the female is 35 years old, and is wounded at most by hornet stings when the male is out of business, wherein the stinged parts of the arms 1, the hand backs 2 and the heads 2 are red, swollen and swollen, and the symptoms of heartache and chest distress appear; the medicine in the embodiment 1 is wetted by gauze or cotton, and then is applied to the affected part, the application frequency and the application area are increased, the medicine is applied to the periphery of the affected part to prevent the peak poison from spreading, and after 15-30 minutes of application, the redness and swelling and pain of the face and the arms are relieved and gradually disappear, and the symptoms of heartache and chest distress are relieved. It indicates that the bee venom in the patient is already removed or the concentration is very low, and the bee venom has no influence on the patient.
Patient 2: the male, 45 years old, is stunted to many parts and injured by the big wasp when going out for business, wherein the symptoms of chest distress and palpitation appear at the arm 1, the hand back 1 and the head 1 after being stunted, and the stunted part shows red swelling and distending pain. The medicine of the example 1 is dipped in the moisture of gauze or cotton and then is smeared on the affected part, and after 20 to 40 minutes of smearing, the redness and swelling, distending pain, chest distress and palpitation are relieved, all the redness and swelling and distending pain of the patient gradually disappear, and the patient returns to normal.
In 1 year, 30 patients suffering from bee sting poisoning are randomly treated by the medicine of the example 1, wherein 22 patients with mild symptoms and 8 patients with severe symptoms are treated, the treatment effect is counted, 22 patients with mild symptoms are cured, the cure rate is 100%, after the patients with severe symptoms use the medicine, the illness state is relieved, and the patients are recovered to be normal.
The medicine for treating bee venom can be carried about, when people enter mountains, are on the spot where more bee colonies come in and go out, such as farmers, and the like, the medicine is carried about, and after being stinged by bees, the medicine is immediately smeared at the sting position, so that pain can be immediately relieved and detoxification can be immediately carried out; for beekeeper, the medicine can also be carried with the bee to treat the affected part which is stinged by the bee in time.
The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Claims (5)

1. The medicine for treating bee venom is characterized by comprising the following raw materials in parts by weight:
10-20 parts of arrowhead, 10-20 parts of ramie leaf, 10-20 parts of houttuynia cordata and 5-10 parts of paris polyphylla.
2. The medicine for treating bee venom according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 15 parts of arrowhead, 15 parts of ramie leaf, 15 parts of houttuynia cordata and 5 parts of paris polyphylla.
3. The medicine for treating bee venom according to claim 1, further comprising, in parts by weight: 1-5 parts of dandelion.
4. The medicine for treating bee venom according to claim 3, which is characterized by comprising the following raw materials in parts by weight: 15 parts of arrowhead, 15 parts of ramie leaf, 15 parts of houttuynia cordata, 5 parts of paris polyphylla and 5 parts of dandelion.
5. A process for the preparation of a medicament for the treatment of bee venom as claimed in any one of claims 1 to 4, comprising the steps of;
s1, selecting fresh arrowhead, ramie leaf, houttuynia cordata and paris polyphylla, cleaning, uniformly mixing, squeezing and collecting juice;
s2, selecting dandelion, cleaning, squeezing and collecting juice;
and S3, combining the juices in the step S1 and the step S2, and concentrating.
CN202111164924.1A 2021-09-30 2021-09-30 Medicine for treating bee venom and preparation method thereof Pending CN113813319A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116650466A (en) * 2023-07-11 2023-08-29 李天才 Detoxication preparation with blood heat clearing effect and preparation method and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101116700A (en) * 2007-08-14 2008-02-06 马正华 Chinese herbal medicine for treating honeybee sting

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101116700A (en) * 2007-08-14 2008-02-06 马正华 Chinese herbal medicine for treating honeybee sting

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
浙江省中医院研究所 等: "《医方类聚 校点本》", 30 September 1982, 人民卫生出版社 *
湖南省中医药研究所: "《湖南药物志第2辑》", 31 October 1972 *
禤国维: "几种常见昆虫性皮肤病中医治疗", 《实用医学杂志》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116650466A (en) * 2023-07-11 2023-08-29 李天才 Detoxication preparation with blood heat clearing effect and preparation method and application thereof

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