CN116650466A - Detoxication preparation with blood heat clearing effect and preparation method and application thereof - Google Patents
Detoxication preparation with blood heat clearing effect and preparation method and application thereof Download PDFInfo
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- CN116650466A CN116650466A CN202310851075.XA CN202310851075A CN116650466A CN 116650466 A CN116650466 A CN 116650466A CN 202310851075 A CN202310851075 A CN 202310851075A CN 116650466 A CN116650466 A CN 116650466A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 56
- 230000000694 effects Effects 0.000 title claims abstract description 51
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 32
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 claims abstract description 29
- YEIGUXGHHKAURB-VAMGGRTRSA-N viridin Chemical compound O=C1C2=C3CCC(=O)C3=CC=C2[C@@]2(C)[C@H](O)[C@H](OC)C(=O)C3=COC1=C23 YEIGUXGHHKAURB-VAMGGRTRSA-N 0.000 claims abstract description 27
- 108010086097 viridin Proteins 0.000 claims abstract description 27
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- 239000003814 drug Substances 0.000 claims abstract description 17
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- 238000000034 method Methods 0.000 claims description 9
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- 230000015572 biosynthetic process Effects 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/305—Mercury compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The application discloses a detoxication preparation with a blood heat clearing effect, and a preparation method and application thereof, belonging to the technical field of medicines for treating hyperlipidemia. The application discloses a detoxication preparation with the effect of clearing blood heat, which comprises the following raw materials: viridin, merthiolate and alcohol. The medicine provided by the application has curative effects on diseases such as wasp stings, snake bites which cannot be vaccinated and toxic and discharged or cat and dog bites which cannot be vaccinated, blood fat which is thick throughout the year, hypertension, insomnia, foot odor, urticaria and the like. The detoxication preparation with the blood heat clearing effect has the effects of clearing blood heat and detoxication and sterilization, and is simple and convenient to carry.
Description
Technical Field
The application belongs to the technical field of medicines for treating hyperlipidemia, and particularly relates to a detoxication preparation with a blood heat clearing effect, a preparation method and application thereof.
Background
With the continuous development of society, the living standard of people is further improved. Along with the improvement of living standard, diseases of people are increasing. The hyperlipidemia is caused by excessive fat content in blood and increased blood viscosity due to high blood lipid. People with high blood lipid need to pay more attention to the life rule, stay up night less, reasonably arrange working time, avoid too high working pressure and tension, and cause the rise of blood lipid. In the aspect of diet, the food with high fat and high sugar is also taken less, so that the body is prevented from being completely metabolized, and fat and cholesterol are left in the body, so that the blood fat is thickened.
In general, the main components in blood lipids are triglycerides and cholesterol, where triglycerides are involved in energy metabolism in humans, and cholesterol is mainly used for the synthesis of cytoplasmic membranes, steroid hormones and bile acids. Hyperlipidemia refers to a condition of high blood lipid level, which can directly cause some diseases seriously harming human health, such as atherosclerosis, coronary heart disease, pancreatitis, etc. Meanwhile, hypertension, insomnia, foot odor and hives are all diseases caused by thick blood fat. Therefore, the hyperlipidemia needs to be controlled so that the hyperlipidemia does not cause diseases due to excessive hyperlipidemia. Most of the existing hypolipidemic drugs have side effects on human bodies.
Disclosure of Invention
The application provides a detoxication preparation with the effect of clearing blood heat, a preparation method and application thereof, which has excellent effect of clearing blood heat and has special curative effect on various diseases caused by thick blood fat.
In a first aspect, the application provides a detoxification preparation with a blood heat clearing effect, which comprises the following raw materials: viridin, merthiolate and alcohol.
Preferably, the ratio of the viridin, the merthiolate and the alcohol is 1-3 g to 10-30 mL.
Preferably, the ratio of the viridin, the merthiolate and the alcohol is 1-2 g to 10-20 mL.
Preferably, the ratio of the viridin, the merthiolate and the alcohol is 1.5g to 15mL.
Preferably, the volume fraction of the alcohol is not less than 95%.
In a second aspect, the application provides a method for preparing the detoxication preparation with the effect of clearing blood heat according to any one of the first aspect, wherein after the viridin, the merthiolate and the alcohol are stirred and mixed, stirring is continued for 4-5 min, and sealing and preserving are carried out after melting.
In a third aspect, the present application provides an application of the detoxification preparation with blood heat clearing effect according to any one of the first aspect in preparing a medicament for treating and/or preventing hyperlipidemia, hypertension, urticaria, wasp stings or snake bites.
Preferably, the medicine for treating and/or preventing the blood lipid thickening has the efficacy component of a detoxification preparation with the effect of clearing blood heat.
Preferably, the medicine for treating wasp stings has the effective components of a detoxification preparation with the effect of clearing blood heat.
Preferably, the medicine for treating snake bite has the effective components of detoxication preparation with blood heat clearing effect.
Preferably, the medicine for treating and/or preventing hypertension has the effective components of a detoxication preparation with the effect of clearing blood heat.
Preferably, the medicine for treating and/or preventing urticaria has the effective component of detoxication preparation with blood heat clearing effect.
Preferably, the medicine for treating insomnia has the efficacy component of a detoxification preparation with the effect of clearing blood heat.
Preferably, the medicine for treating foot odor has the efficacy component of a detoxification preparation with the effect of clearing blood heat.
Compared with the prior art, the technical scheme provided by the embodiment of the application has at least the following advantages:
1. the detoxication preparation with the blood heat clearing effect disclosed by the application is an external basic prescription, wherein the viridin mainly has the function of sterilization, can kill bacillus and candida, is a medical medicament, and does not cause any harm to the body compared with a chemical preparation. The merthiolate has the effects of activating nerves, removing damp heat and dispelling cold, has fresh-keeping effect, and can kill fungi, so that the detoxication preparation can be stored for a long time, the efficacy is not reduced, and the preparation does not deteriorate in a short time.
2. The detoxication preparation with the blood heat clearing effect disclosed by the application has broad-spectrum treatment effect, and has prevention and treatment effects on diseases such as hypertension, halitosis, foot odor, insomnia, urticaria and the like caused by thick blood fat. It also has therapeutic effect on traumatic infection, such as venomous snake bite, cat and dog scratch or bite, and wasp sting. Meanwhile, the preparation can be packaged, is easy to carry when going out outdoors at ordinary times, can be used for prevention, and can detoxify or delay the diffusion of toxin at critical time.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the application and together with the description, serve to explain the principles of the application.
In order to more clearly illustrate the embodiments of the application or the technical solutions of the prior art, the drawings which are used in the description of the embodiments or the prior art will be briefly described, and it will be obvious to a person skilled in the art that other drawings can be obtained from these drawings without inventive effort.
FIG. 1 is a schematic representation of the change in ear redness before and after the present application case 1 is stinged;
fig. 2 is a diagram showing the color change of the mouth after the present application case 2 was stined.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present application more apparent, the technical solutions of the embodiments of the present application will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present application, and it is apparent that the described embodiments are some embodiments of the present application, but not all embodiments of the present application. All other embodiments, which can be made by those skilled in the art based on the embodiments of the application without making any inventive effort, are intended to be within the scope of the application.
Unless otherwise specifically indicated, the various raw materials, reagents, instruments, equipment and the like used in the present application are commercially available or may be prepared by existing methods.
In a first aspect, the application provides a detoxification preparation with a blood heat clearing effect, which comprises the following raw materials: viridin, merthiolate and alcohol.
Preferably, the ratio of the viridin, the merthiolate and the alcohol is 1-3 g to 10-30 mL.
In the present application, the weight of the viridin may be 1g, 1.1g, 1.2g, 1.3g, 1.4g, 1.5g, 1.6g, 1.7g, 1.8g, 1.9g, 2.0g, 2.1g, 2.2g, 2.3g, 2.4g, 2.5g, 2.6g, 2.7g, 2.8g, 2.9g, 3.0g, etc.
In the present application, the weight of the merthiolate may be 1g, 1.1g, 1.2g, 1.3g, 1.4g, 1.5g, 1.6g, 1.7g, 1.8g, 1.9g, 2.0g, 2.1g, 2.2g, 2.3g, 2.4g, 2.5g, 2.6g, 2.7g, 2.8g, 2.9g, 3.0g, etc.
In the present application, the volume of the alcohol may be 10mL, 11mL, 12mL, 13mL, 14mL, 15mL, 16mL, 17mL, 18mL, 19mL, 20mL, 21mL, 22mL, 23mL, 24mL, 25mL, 26mL, 27mL, 28mL, 29mL, 30mL, or the like.
The proportions of the viridin, the merthiolate and the alcohol can be appropriately adjusted within the range of the proportion of the application.
Preferably, the ratio of the viridin, the merthiolate and the alcohol is 1-2 g to 10-20 mL.
The inventor finds that the detoxification effect of the detoxification preparation is best under the condition that the ratio of the viridin, the merthiolate and the alcohol is 1.5g to 15mL.
Preferably, the volume fraction of the alcohol is not less than 95%, and is a high alcohol.
In a second aspect, based on an inventive technical concept, the present application provides a method for preparing the detoxication preparation with blood heat clearing effect according to any one of the first aspect, wherein the method comprises stirring and mixing the viridin, the merthiolate and the alcohol, continuing stirring for 4-5 min, melting and sealing for preservation.
In the application, the method for mixing the viridin, the merthiolate and the alcohol can be mechanical stirring or manual stirring, and the stirring space can be sterile or prepared in a conventional space. Meanwhile, the preparation temperature, humidity and the like have no requirements. The detoxification preparation disclosed by the application is simple in preparation method and raw materials, can be prepared by any person, and is especially convenient and effective for people living in the field for a long time.
In a third aspect, based on the technical concept of the application, the application provides an application of the detoxification preparation with the effect of clearing blood heat in any one of the first aspect in preparing a medicament for treating and/or preventing thick blood lipid, hypertension, urticaria, wasp stings or snake bites.
The principles and features of the present application are described below in connection with the following examples, which are set forth to illustrate, but are not to be construed as limiting the scope of the application. The specific conditions are not noted in the examples and are carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or apparatus used were conventional products commercially available without the manufacturer's attention.
Example 1
The embodiment provides a detoxification preparation with the effect of clearing blood heat, which comprises the following raw materials: 1.5g of viridin, 1.5g of merthiolate and 15mL of 95% (v/v) alcohol.
Example 2
The embodiment provides a detoxification preparation with the effect of clearing blood heat, which comprises the following raw materials: 2.0g of viridin, 1.5g of merthiolate and 15mL of 95% (v/v) alcohol.
Example 3
The embodiment provides a detoxification preparation with the effect of clearing blood heat, which comprises the following raw materials: 1.5g of viridin, 2.0g of merthiolate and 15mL of 95% (v/v) alcohol.
Example 4
The embodiment provides a detoxification preparation with the effect of clearing blood heat, which comprises the following raw materials: green mycin 1.5g, merthiolate 1.5g,95% (v/v) alcohol 30mL.
Example 5
The embodiment provides a detoxification preparation with the effect of clearing blood heat, which comprises the following raw materials: green mycin 1.5g, merthiolate 1.5g,95% (v/v) alcohol 20mL.
Example 6
The embodiment provides a detoxification preparation with the effect of clearing blood heat, which comprises the following raw materials: 3.0g of viridin, 3.0g of merthiolate and 30mL of 99% (v/v) alcohol.
Example 7
The embodiment provides a detoxification preparation with the effect of clearing blood heat, which comprises the following raw materials: 1.0g of viridin, 3.0g of merthiolate and 15mL of 97% (v/v) alcohol.
Example 8
The embodiment provides a detoxification preparation with the effect of clearing blood heat, which comprises the following raw materials: 2.0g of viridin, 2.0g of merthiolate and 15mL of 98% (v/v) alcohol.
Example 9
The embodiment provides a detoxification preparation with the effect of clearing blood heat, which comprises the following raw materials: 3.0g of viridin, 1.0g of merthiolate and 20mL of 96% (v/v) alcohol.
The using method comprises the following steps:
(1) The application times of the plaster are not limited, and the plaster can be applied to ears for maintenance and prevention of diseases such as thick blood fat, hypertension, hives and the like all the year round, and has no risk for external use. Can also clean vision and improve memory after treatment.
The medicine-applied and sterilization part on the back of the ear can be subjected to itching and heating, alkaline hydrolysis can be used, the medicine-applied and sterilization part can automatically and completely fall off after scabbing, and in the antibacterial process, the effect of boiling in-vivo microorganisms along with blood is best, and the medicine-applied and sterilization part can be a method for drinking medicinal liquor, for example, health-care brand pine cone snake gall medicinal liquor is matched, and the medicine-applied and sterilization part contains a large amount of vitamin enzymes and can promote blood circulation.
(2) The patient with severe symptoms is matched with sodium benzoate for cleaning, 4-5g of sodium benzoate is firstly melted by boiled water and then the affected part is cleaned, and then the product is matched with the application for use, so that the treatment effect can be achieved after 1 week. Notably, the sodium benzoate can dry the skin, and patients have to drink water to keep the skin moist when the sodium benzoate is matched,
the detoxification preparation is a secret formula of the inventor family, and the inventor family can be used for a long time for preventing and maintaining, so that no thick blood lipid case exists. Meanwhile, as shown in figure 1, a patient with the yang is stinged by hornet, and the lips are purple to form viruses, and after the product is used for 3 days, the hornet venom with normal lip color is relieved. As shown in FIG. 2, a patient's ear was stinged, a large swelling was produced, and the detoxification preparation of the present application was restored to normal after two days.
Various embodiments of the application may exist in a range of forms; it should be understood that the description in a range format is merely for convenience and brevity and should not be construed as a rigid limitation on the scope of the application; it is therefore to be understood that the range description has specifically disclosed all possible sub-ranges and individual values within that range. For example, it should be considered that a description of a range from 1 to 6 has specifically disclosed sub-ranges, such as from 1 to 3, from 1 to 4, from 1 to 5, from 2 to 4, from 2 to 6, from 3 to 6, etc., as well as single numbers within the range, such as 1, 2, 3, 4, 5, and 6, wherever applicable. In addition, whenever a numerical range is referred to herein, it is meant to include any reference number (fractional or integer) within the indicated range.
The foregoing is only a specific embodiment of the application to enable those skilled in the art to understand or practice the application. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the application. Thus, the present application is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (10)
1. A detoxication preparation with the effect of clearing blood heat is characterized by comprising the following raw materials: viridin, merthiolate and alcohol.
2. The detoxication preparation with the effect of clearing heat and blood according to claim 1, wherein the ratio of the viridin, the merthiolate and the alcohol is 1-3 g to 10-30 mL.
3. The detoxication preparation with blood heat clearing effect according to claim 2, wherein the ratio of the viridin, the merthiolate and the alcohol is 1-2 g to 10-20 mL.
4. The detoxication formulation with blood heat clearing effect according to claim 3, wherein the ratio of the viridin, the merthiolate and the alcohol is 1.5g to 15ml.
5. The detoxication preparation with blood heat clearing effect according to any one of claims 1 to 4, wherein the volume fraction of the alcohol is not less than 95%.
6. A method for preparing the detoxication preparation with the effect of clearing blood heat according to any one of claims 1 to 5, which is characterized in that after the viridin, the merthiolate and the alcohol are stirred and mixed, stirring is continued for 4 to 5 minutes, and sealing and preserving are carried out after melting.
7. Use of the detoxication preparation with blood heat clearing effect according to any one of claims 1 to 5 in the preparation of a medicament for treating hyperlipidemia, hypertension, urticaria, wasp stings or snake bites.
8. A medicament for treating hyperlipidemia, which is characterized in that the effective components are detoxification preparations with the blood heat clearing effect according to any one of claims 1 to 5.
9. A medicament for treating wasp stings, which is characterized in that the effective components are detoxification preparations with the effect of clearing blood heat according to any one of claims 1-5.
10. A medicament for treating snake bite, which is characterized in that the effective components are detoxification preparations with the effect of clearing blood heat according to any one of claims 1-5.
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Citations (4)
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|---|---|---|---|---|
| JP2005023242A (en) * | 2003-07-04 | 2005-01-27 | Picaso Cosmetic Laboratory Ltd | Antioxidant and external preparation for skin |
| US20090148512A1 (en) * | 2007-12-07 | 2009-06-11 | Lannett Co Inc | Novel uses of chloramphenicol and analogous thereof |
| US20190125815A1 (en) * | 2016-05-30 | 2019-05-02 | Yuanqiao Fu | Topical Pharmaceutical Composition for Treating Multiple Wounds of Skin and the Preparation Methods Thereof |
| CN113813319A (en) * | 2021-09-30 | 2021-12-21 | 林加城 | Medicine for treating bee venom and preparation method thereof |
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2023
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005023242A (en) * | 2003-07-04 | 2005-01-27 | Picaso Cosmetic Laboratory Ltd | Antioxidant and external preparation for skin |
| US20090148512A1 (en) * | 2007-12-07 | 2009-06-11 | Lannett Co Inc | Novel uses of chloramphenicol and analogous thereof |
| US20190125815A1 (en) * | 2016-05-30 | 2019-05-02 | Yuanqiao Fu | Topical Pharmaceutical Composition for Treating Multiple Wounds of Skin and the Preparation Methods Thereof |
| CN113813319A (en) * | 2021-09-30 | 2021-12-21 | 林加城 | Medicine for treating bee venom and preparation method thereof |
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