CN110302263A - A kind for the treatment of spraying agent for ulcer of oral cavity of the ingredient containing trollflower and preparation method thereof - Google Patents

A kind for the treatment of spraying agent for ulcer of oral cavity of the ingredient containing trollflower and preparation method thereof Download PDF

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CN110302263A
CN110302263A CN201910720177.1A CN201910720177A CN110302263A CN 110302263 A CN110302263 A CN 110302263A CN 201910720177 A CN201910720177 A CN 201910720177A CN 110302263 A CN110302263 A CN 110302263A
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ulcer
extract
oral cavity
added
spraying agent
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高旭华
王一飞
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Guangdong Dapeng Medicine Technology Co Ltd
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Guangdong Dapeng Medicine Technology Co Ltd
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Abstract

The present invention provides a kind for the treatment of spraying agent for ulcer of oral cavity of ingredient containing trollflower, every 1000mL treatment spraying agent for ulcer of oral cavity includes following components: Flos Trollii extract 28-32g, purslane extract 14-16g, bletilla polysaccharide 48-52g, sorbic acid 0.4-0.6g, borneol 4-6g, menthol 4-6g, surfactant 4-6g, rose hip extract 3-5g, remaining is water.The present invention also provides the preparation methods of the treatment spraying agent for ulcer of oral cavity.Treatment spraying agent for ulcer of oral cavity provided by the invention has good curative effect to recurrent aphtha stomatitis and traumatic ulcer, the healing cycle that can effectively mitigate pain, shorten wound.

Description

A kind for the treatment of spraying agent for ulcer of oral cavity of the ingredient containing trollflower and preparation method thereof
Technical field
Spraying agent for ulcer of oral cavity is treated the present invention relates to a kind of, is burst more particularly to a kind for the treatment of oral cavity of ingredient containing trollflower Ulcer spray and preparation method thereof.
Background technique
Canker sore is commonly called as " aphtha ", is a kind of common ulcerative damages illness for betiding mucous membrane of mouth, sick hair phase Between sharp ache, local cusalgia is obvious, and serious person also will affect diet, speak, and causes very big inconvenience to daily life.It faces There are many kinds of bed performances, mainly includes recurrent aphtha stomatitis and traumatic ulcer.
On the market for the pharmaceutical intervention product of above two canker sore mainly have antibiotics or idodine class fungicide, The Chinese materia medica preparation of glucocorticoids anti-inflammatory agent, clearing heat, releasing toxin, removing swelling analgesic class.The potential drug resistance risk of antibiotics, sugared cortical hormone Plain class can inhibit the healing of wound while anti-inflammatory, in contrast compound Chinese medicinal preparation is advantageous in terms of safety.
Application No. is the patents of CN201510466224.6 to disclose " a kind of drug for treating canker sore ", the skill of use Art scheme are as follows: a kind of drug for treating canker sore, it is to be prepared from the following raw materials in parts by weight: 300-400 parts of evodia rutaecarpa, 100-240 parts and borax 60-120 parts of kapur.The patent the problem is that, to recurrent aphtha stomatitis and wound The actual efficacy of property ulcer is bad, and borax has certain harm to human body.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind for the treatment of spraying agent for ulcer of oral cavity of ingredient containing trollflower, to multiple Hair property aphtha stomatitis and traumatic ulcer have good curative effect, the healing cycle that can effectively mitigate pain, shorten wound.
In order to solve the above technical problems, the technical scheme is that
A kind for the treatment of spraying agent for ulcer of oral cavity of the ingredient containing trollflower, every 1000mL treatment spraying agent for ulcer of oral cavity includes following components: Flos Trollii extract 28-32g, purslane extract 14-16g, bletilla polysaccharide 48-52g, sorbic acid 0.4-0.6g, borneol 4-6g, Menthol 4-6g, surfactant 4-6g, rose hip extract 3-5g, remaining is water.
Further, Flos Trollii extract of the present invention is made by following steps:
Trollflower is added water to cook it is secondary, filtration obtain filtrate one, by filtrate one be concentrated into 60 DEG C of relative densities be 1.18- 1.22, ethyl alcohol, which is added, makes volume fraction of ethanol reach 60%, stirs evenly, stands 24 hours at 0-4 DEG C, and filtration obtains filtrate two, Filtrate two is recycled into ethyl alcohol and is concentrated, adding water to 30 DEG C of relative densities is that 1.05-1.08 obtains mixed liquor one, after active carbon is added It is stirred 40 minutes at 60 DEG C, stirring is cooled to room temperature, and filtration obtains the as Flos Trollii extract of filter residue one after diatomite is added.
Further, in the preparation step of Flos Trollii extract of the present invention, the weight of active carbon is one weight of mixed liquor The 1% of amount, the weight of diatomite are the 3% of one weight of mixed liquor.
Further, purslane extract of the present invention is made by following steps:
Purslane is added water to cook it is secondary, filtration obtain filtrate three, by filtrate three be concentrated into 60 DEG C of relative densities be 1.18- 1.22, ethyl alcohol, which is added, makes volume fraction of ethanol reach 60%, stirs evenly, stands 24 hours at 0-4 DEG C, and filtration obtains filtrate four, Filtrate four is recycled into ethyl alcohol and is concentrated, adding water to 30 DEG C of relative densities is that 1.05-1.08 obtains mixed liquor two, after active carbon is added 40min is stirred at 60 DEG C, stirring is cooled to room temperature, and filtration obtains the as purslane extract of filter residue two after diatomite is added.
Further, in the preparation step of purslane extract of the present invention, the weight of active carbon is that mixed liquor is double The 1% of amount, the weight of diatomite are the 3% of two weight of mixed liquor.
Further, bletilla polysaccharide of the present invention is made by following steps:
The bletilla striata is ground into middle powder one, it is secondary that middle powder one is added to the water constant temperature stirring and leaching at 70-80 DEG C, and one hour every time, Filtration obtains filtrate four, and it is 1.05-1.08 that filtrate four, which is concentrated into 60 DEG C of relative densities, and centrifugation obtains supernatant, by supernatant Continue to be concentrated into 60 DEG C of relative densities to be 1.18-1.22, ethyl alcohol, which is added, makes volume fraction of ethanol reach 70%, stirs evenly, 0-4 24 hours are stood at DEG C, it is bletilla polysaccharide that centrifugation, which obtains precipitating,.
Further, surfactant of the present invention is Tween 80.
Further, rose hip extract of the present invention is made by following steps:
Middle powder two is ground into after cynarrhodion is enucleated, it is 3 that middle powder two, which is added after water, and adjusts pH value, is heated after zytase is added To 55 DEG C, stirring boils enzyme deactivation in 5 minutes and obtains extracting solution after extracting 2.5 hours, will extract solution and is centrifuged to obtain supernatant, adds Entering ethyl alcohol makes volume fraction of ethanol reach 75%, is stored at room temperature filtration after precipitating 2 hours and obtains filter residue three, is by the drying of filter residue three Obtain rose hip extract.
Another technical problem to be solved by the present invention is that the treatment spraying agent for ulcer of oral cavity of the above-mentioned ingredient containing trollflower is provided Preparation method.
In order to solve the above technical problems, technical solution is:
A kind of preparation method of the treatment spraying agent for ulcer of oral cavity of the ingredient containing trollflower, comprising the following steps:
Borneol, menthol are ground to melting, the water grinding that the weight such as surfactant and surfactant are then added is equal It is even, it is mixed under stirring condition with trollflower, purslane extract, bletilla polysaccharide, rose hip extract, is stirring evenly and then adding into mountain Pears acid simultaneously adds water to 1000ml, continues after mixing evenly up to treatment spraying agent for ulcer of oral cavity.
Compared with prior art, the invention has the following advantages:
(1) trollflower, bitter is cold in nature, clearing heat and detoxicating, commonly uses for upper sense, tonsillitis, pharyngitis, otitis media acuta, acute drum Film is scorching, acute conjunctivitis, acute lymphangitis, aphtha, furunculosis；Purslane, it is sour, it is cold in nature, be applied to outside furuncle swelling toxin have it is scattered The function of blood detumescence；Borneol, it is pungent, bitter, it is slightly cold, there is clearing heat and detoxicating, erosion prevention and muscle growing effect；Menthol, aromatic drug, remedium corrigens, is used for Skin or mucous membrane generate refrigerant sense to mitigate uncomfortable and pain；The bletilla striata, it is bitter, it puts down, it is nontoxic, subcutaneous ulcer is lost with myogenic for Carbuncle swells dislikes sore The effect of analgesic；The present invention by trollflower, purslane in the form of extract, by the bletilla striata in the form of polysaccharide, with borneol, peppermint Brain makes an addition in spray together, each component generate synergy so that spray to recurrent aphtha stomatitis and it is traumatic burst Ulcer has good curative effect, the healing cycle that can effectively mitigate pain, shorten wound.
(2) Flos Trollii extract that the present invention uses also has preferable anti-other than having curative effect to canker sore The effect of bacterium, anti-inflammatory analgetic；Purslane extract also has preferable anti-inflammatory analgetic other than having curative effect to canker sore The effect of；.Bletilla polysaccharide also has preferable anti-inflammatory analgetic, inhibits bleeding gums other than having curative effect to canker sore The effect of.
(3) cynarrhodion is the fruit of rosaceous plant, and containing Multiple components such as pectin, citric acid, malic acid, the present invention will Cynarrhodion obtains rose hip extract by Enzymatic Extraction, has effects that preferable anti-inflammatory analgetic, inhibits bleeding gums, this Outside, rose hip extract can also improve the dispersion stabilization of spray.
Specific embodiment
Below in conjunction with specific embodiment, the present invention will be described in detail, herein illustrative embodiments and their description of the invention For explaining the present invention, but it is not as a limitation of the invention.
Embodiment 1
The treatment spraying agent for ulcer of oral cavity of the ingredient containing trollflower, every 1000mL treatment spraying agent for ulcer of oral cavity includes following components: lily feet Flower extract 30g, purslane extract 15g, bletilla polysaccharide 50g, sorbic acid 0.5g, borneol 5g, menthol 5g, Tween 80 5g, Rose hip extract 4g, remaining is water.
The preparation method of the embodiment the following steps are included:
(1) trollflower is added water to cook it is secondary, filtration obtain filtrate one, by filtrate one be concentrated into 60 DEG C of relative densities be 1.18- 1.22, ethyl alcohol, which is added, makes volume fraction of ethanol reach 60%, stirs evenly, stands 24 hours at 0-4 DEG C, and filtration obtains filtrate two, Filtrate two is recycled into ethyl alcohol and is concentrated, adding water to 30 DEG C of relative densities is that 1.05-1.08 obtains mixed liquor one, after active carbon is added It is stirred 40 minutes at 60 DEG C, stirring is cooled to room temperature, and filtration obtains the as Flos Trollii extract of filter residue one after diatomite is added；It is living Property charcoal weight be the 1% of one weight of mixed liquor, the weight of diatomite is the 3% of one weight of mixed liquor；
(2) purslane is added water to cook it is secondary, filtration obtain filtrate three, by filtrate three be concentrated into 60 DEG C of relative densities be 1.18- 1.22, ethyl alcohol, which is added, makes volume fraction of ethanol reach 60%, stirs evenly, stands 24 hours at 0-4 DEG C, and filtration obtains filtrate four, Filtrate four is recycled into ethyl alcohol and is concentrated, adding water to 30 DEG C of relative densities is that 1.05-1.08 obtains mixed liquor two, after active carbon is added 40min is stirred at 60 DEG C, stirring is cooled to room temperature, and filtration obtains the as purslane extract of filter residue two after diatomite is added；It is living Property charcoal weight be the 1% of two weight of mixed liquor, the weight of diatomite is the 3% of two weight of mixed liquor；
(3) bletilla striata is ground into middle powder one, middle powder one is added to the water to constant temperature stirring and leaching at 70-80 DEG C is secondary, and one is small every time When, filtration obtains filtrate four, and it is 1.05-1.08 that filtrate four, which is concentrated into 60 DEG C of relative densities, and centrifugation obtains supernatant, by supernatant Liquid continues to be concentrated into 60 DEG C of relative densities to be 1.18-1.22, and ethyl alcohol, which is added, makes volume fraction of ethanol reach 70%, stirs evenly, 0- 24 hours are stood at 4 DEG C, it is bletilla polysaccharide that centrifugation, which obtains precipitating,；
(4) middle powder two is ground into after being enucleated cynarrhodion, it is 3 that middle powder two, which is added after water, and adjusts pH value, after zytase is added 55 DEG C are heated to, stirring boils enzyme deactivation in 5 minutes and obtains extracting solution after extracting 2.5 hours, will extract solution and be centrifuged to obtain supernatant Liquid, ethyl alcohol, which is added, makes volume fraction of ethanol reach 75%, is stored at room temperature filtration after precipitating 2 hours and obtains filter residue three, filter residue three is dried Dry rose hip extract to obtain the final product；
(5) borneol, menthol are ground to melting, the water grinding that the weight such as Tween 80 and Tween 80 are then added uniformly, is stirred Under the conditions of mixed with trollflower, purslane extract, bletilla polysaccharide, rose hip extract, be stirring evenly and then adding into sorbic acid simultaneously 1000ml is added water to, is continued after mixing evenly up to treatment spraying agent for ulcer of oral cavity.
Embodiment 2
The treatment spraying agent for ulcer of oral cavity of the ingredient containing trollflower, every 1000mL treatment spraying agent for ulcer of oral cavity includes following components: lily feet Flower extract 28g, purslane extract 16g, bletilla polysaccharide 49g, sorbic acid 0.5g, borneol 4g, menthol 6g, Tween 80 6g, Rose hip extract 5g, remaining is water.
The preparation method of the embodiment is same as Example 1.
Embodiment 3
The treatment spraying agent for ulcer of oral cavity of the ingredient containing trollflower, every 1000mL treatment spraying agent for ulcer of oral cavity includes following components: lily feet Flower extract 32g, purslane extract 14g, bletilla polysaccharide 48g, sorbic acid 0.6g, borneol 4.5g, menthol 4.5g, Tween 80 4.5g, rose hip extract 3g, remaining is water.
The preparation method of the embodiment is same as Example 1.
Embodiment 4
The treatment spraying agent for ulcer of oral cavity of the ingredient containing trollflower, every 1000mL treatment spraying agent for ulcer of oral cavity includes following components: lily feet Flower extract 29g, purslane extract 14.5g, bletilla polysaccharide 52g, sorbic acid 0.4g, borneol 6g, menthol 4g, Tween 80 4g, rose hip extract 4.5g, remaining is water.
The preparation method of the embodiment is same as Example 1.
Comparative Examples 1
It does not unlike the first embodiment include Flos Trollii extract in component.
Comparative Examples 2
It does not unlike the first embodiment include purslane extract in component.
Comparative Examples 3
It does not unlike the first embodiment include bletilla polysaccharide in component.
Comparative Examples 4
It does not unlike the first embodiment include rose hip extract in component.
Comparative example
Application No. is the embodiments 1 of the Chinese patent of CN201510466224.6.
Experimental example one: recurrent aphtha stomatitis curative effect test
Test method: choose 171 ages be 22-60 years old, the recurrent aphtha stomatitis patient that average course of disease is 3 years, with Machine is divided into 9 groups, and every group of patient uses embodiment 1-4, Comparative Examples 1-4, comparative example respectively, uses daily twice, 4 weeks Patient evaluates curative effect after it, and criterion of therapeutical effect is divided into effective, effective, invalid three-level: effective judgment criteria is recurrent aphtha Property break out total intermittent time of stomatitis be obviously prolonged or even do not reaccess, total ulcer number, which significantly reduces, even to disappear；Effective judgement Standard is to extend recurrent aphtha stomatitis breaking-out total intermittent time, and total ulcer number is reduced；Invalid judgment criteria is recurrence Property aphtha stomatitis total intermittent time, total ulcer number do not change.Calculate every group of recurrent aphtha stomatitis treatment Effective percentage, recurrent aphtha stomatitis treated effect=(effective patient numbers+effective patient numbers)/19 × 100%.
Test result is as shown in table 1:
Recurrent aphtha stomatitis treated effect (%)
Embodiment 1 94.7
Embodiment 2 89.5
Embodiment 3 89.5
Embodiment 4 89.5
Comparative Examples 1 68.4
Comparative Examples 2 73.7
Comparative Examples 3 73.7
Comparative Examples 4 89.5
Comparative example 47.4
Table 1
As seen from Table 1, the recurrent aphtha stomatitis treated effect of 1-4 of the embodiment of the present invention is obviously higher than comparison Example shows that the present invention has a better effect recurrent aphtha stomatitis tool.The constituent part of Comparative Examples 1-4 and implementation Example 1 is different, and wherein the recurrent aphtha stomatitis treated effect of Comparative Examples 1-3 is declined, and illustrates trollflower Extract, purslane extract, bletilla polysaccharide can improve spray to the curative effect of recurrent aphtha stomatitis.
Experimental example two: traumatic ulcer curative effect test
Test method: choosing the traumatic ulcer patient that 171 ages are 22-60 years old, and stochastic averagina is divided into 9 groups, every group of patient Embodiment 1-4, Comparative Examples 1-4, comparative example are used respectively, and daily using twice, 4 Zhou Tianhou patients evaluate curative effect, curative effect Standard is divided into effective, effective, invalid three-level: effective judgment criteria is that ulcer surface healing or visible ulcer area substantially reduce； Effective judgment criteria is that visible ulcer area reduces 50% or more；Invalid judgment criteria be visible ulcer area reduce 50% with Under.Every group of traumatic ulcer treated effect is calculated, traumatic ulcer treated effect=(effective patient numbers+effectively trouble Person's number)/19 × 100%.
Test result is as shown in table 2:
Traumatic ulcer treated effect (%)
Embodiment 1 100
Embodiment 2 94.7
Embodiment 3 94.7
Embodiment 4 94.7
Comparative Examples 1 68.4
Comparative Examples 2 78.9
Comparative Examples 3 78.9
Comparative Examples 4 100
Comparative example 52.6
Table 2
As seen from Table 2, the traumatic ulcer treated effect of 1-4 of the embodiment of the present invention shows this obviously higher than comparative example Invention has a better effect traumatic ulcer tool.The constituent part of Comparative Examples 1-4 is different from embodiment 1, wherein reference The traumatic ulcer treated effect of embodiment 1-3 is declined, and illustrates Flos Trollii extract, purslane extract, the bletilla striata Polysaccharide can improve spray to the curative effect of traumatic ulcer.
Experimental example three: antibiotic effect test
Embodiment 1-4, Comparative Examples 1-4, comparative example are measured respectively to the antibiotic rate of staphylococcus aureus, and antibiotic rate is higher Then indicate that antibiotic effect is better, test result is as shown in table 3:
Antibiotic rate (%)
Embodiment 1 99.63
Embodiment 2 99.60
Embodiment 3 99.59
Embodiment 4 99.58
Comparative Examples 1 72.85
Comparative Examples 2 99.62
Comparative Examples 3 99.61
Comparative Examples 4 99.62
Comparative example 88.77
Table 3
As seen from Table 3, it is preferable to show that the present invention has obviously higher than comparative example for the antibiotic rate of 1-4 of the embodiment of the present invention Antibiotic effect.The constituent part of Comparative Examples 1-4 is different from embodiment 1, wherein the antibiotic rate of Comparative Examples 1 substantially under Drop illustrates that Flos Trollii extract is the main cause for improving spray antibiotic effect.
Experimental example four: anti-inflammatory analgetic efficacy test
Test method: choosing the patient for having stomatitis swelling and pain symptom that 171 ages are 22-60 years old, and stochastic averagina is divided into 9 groups, Every group of patient uses embodiment 1-4, Comparative Examples 1-4, comparative example respectively, and daily using twice, 1 Zhou Tianhou patient evaluates mouth The improvement situation of chamber inflammation swelling and pain symptom, be divided into effective, effective, invalid three-level: effective judgment criteria is stomatitis swelling and pain symptom Obvious weaken even disappears；Effective judgment criteria is that stomatitis swelling and pain symptom is weakened；Invalid judgment criteria is oral cavity Inflammation swelling and pain symptom does not change.It is efficient to calculate every group of anti-inflammatory analgetic, anti-inflammatory analgetic effective percentage=(effective patient numbers+have Imitate patient numbers)/19 × 100%.
Test result is as shown in table 4:
Anti-inflammatory analgetic effective percentage (%)
Embodiment 1 100
Embodiment 2 94.7
Embodiment 3 100
Embodiment 4 94.7
Comparative Examples 1 68.4
Comparative Examples 2 78.9
Comparative Examples 3 68.4
Comparative Examples 4 78.9
Comparative example 57.9
Table 4
As seen from Table 4, the anti-inflammatory analgetic effective percentage of 1-4 of the embodiment of the present invention shows tool of the present invention obviously higher than comparative example There is preferable anti-inflammatory analgetic effect.The constituent part of Comparative Examples 1-4 is different from embodiment 1, wherein Comparative Examples 1-4 Anti-inflammatory analgetic effective percentage is declined, and illustrates that Flos Trollii extract, purslane extract, bletilla polysaccharide and cynarrhodion are extracted Object can improve anti-inflammatory analgetic effect of spray.
Experimental example five: inhibit bleeding gums efficacy test
Test method: choosing the patient for having the easy bleeding of gum that 171 ages are 22-60 years old, and stochastic averagina is divided into 9 groups, every group Patient uses embodiment 1-4, Comparative Examples 1-4, comparative example respectively, and daily using twice, 1 Zhou Tianhou patient evaluates gum and goes out The improvement situation of blood situation, be divided into effective, effective, invalid three-level: effective judgment criteria is that bleeding gums situation significantly reduces Even disappear；Effective judgment criteria is that bleeding gums situation is reduced；Invalid judgment criteria is that bleeding gums situation does not have It changes.It is efficient to calculate every group of inhibition bleeding gums, inhibits bleeding gums efficient=(effective patient numbers+effectively suffer from Person's number)/19 × 100%.
Test result is as shown in table 5:
Inhibit bleeding gums efficient (%)
Embodiment 1 94.7
Embodiment 2 94.7
Embodiment 3 89.4
Embodiment 4 89.4
Comparative Examples 1 89.4
Comparative Examples 2 89.4
Comparative Examples 3 68.4
Comparative Examples 4 64.2
Comparative example 36.8
Table 5
As seen from Table 5, the inhibition bleeding gums effective percentage of 1-4 of the embodiment of the present invention shows this hair obviously higher than comparative example It is bright to have effects that preferably to inhibit bleeding gums.The constituent part of Comparative Examples 1-4 is different from embodiment 1, and wherein reference is real The inhibition bleeding gums effective percentage for applying a 3-4 is declined, and illustrates that bletilla polysaccharide and rose hip extract can improve spray Anti-inflammatory analgetic effect of agent.
Experimental example six: dispersion stabilization test
Test method: embodiment 1-4, Comparative Examples 1-4 are placed in a centrifuge, at room temperature with 3000 revs/min of centrifugation speed Degree centrifugation 10 minutes, standing observation in 5 minutes, whether there is or not turbid phenomenon occur.Test result is as shown in table 6:
Embodiment 1 Do not occur turbid phenomenon
Embodiment 2 Do not occur turbid phenomenon
Embodiment 3 Do not occur turbid phenomenon
Embodiment 4 Do not occur turbid phenomenon
Comparative Examples 1 Do not occur turbid phenomenon
Comparative Examples 2 Do not occur turbid phenomenon
Comparative Examples 3 Do not occur turbid phenomenon
Comparative Examples 4 There is turbid phenomenon
Table 6
As seen from Table 6,1-4 of the embodiment of the present invention does not occur turbid phenomenon after test, and it is preferable to show that the present invention has Dispersion stabilization.The constituent part of Comparative Examples 1-4 is different from embodiment 1, and wherein Comparative Examples 4 occur muddy existing As illustrating that rose hip extract is the key that improve spray dispersion stabilization.
The principle of the present invention and its performance is only illustrated in above-described embodiment, and is not intended to limit the present invention.It is any ripe The personage for knowing this technology all without departing from the spirit and scope of the present invention, carries out modifications and changes to above-described embodiment.Cause This, institute is complete without departing from the spirit and technical ideas disclosed in the present invention by those of ordinary skill in the art such as At all equivalent modifications or change, should be covered by the claims of the present invention.

Claims (9)

1. a kind for the treatment of spraying agent for ulcer of oral cavity of ingredient containing trollflower, it is characterised in that: every 1000mL treats spraying agent for ulcer of oral cavity Including following components: Flos Trollii extract 28-32g, purslane extract 14-16g, bletilla polysaccharide 48-52g, sorbic acid 0.4- 0.6g, borneol 4-6g, menthol 4-6g, surfactant 4-6g, rose hip extract 3-5g, remaining is water.
2. a kind for the treatment of spraying agent for ulcer of oral cavity of ingredient containing trollflower according to claim 1, it is characterised in that: the gold Flos Nelumbinis extract is made by following steps:
Trollflower is added water to cook it is secondary, filtration obtain filtrate one, by filtrate one be concentrated into 60 DEG C of relative densities be 1.18- 1.22, ethyl alcohol, which is added, makes volume fraction of ethanol reach 60%, stirs evenly, stands 24 hours at 0-4 DEG C, and filtration obtains filtrate two, Filtrate two is recycled into ethyl alcohol and is concentrated, adding water to 30 DEG C of relative densities is that 1.05-1.08 obtains mixed liquor one, after active carbon is added It is stirred 40 minutes at 60 DEG C, stirring is cooled to room temperature, and filtration obtains the as Flos Trollii extract of filter residue one after diatomite is added.
3. a kind for the treatment of spraying agent for ulcer of oral cavity of ingredient containing trollflower according to claim 2, it is characterised in that: the gold In the preparation step of Flos Nelumbinis extract, the weight of active carbon is the 1% of one weight of mixed liquor, and the weight of diatomite is mixed liquor one The 3% of weight.
4. a kind for the treatment of spraying agent for ulcer of oral cavity of ingredient containing trollflower according to claim 1, it is characterised in that: the horse Sativa extract is made by following steps:
Purslane is added water to cook it is secondary, filtration obtain filtrate three, by filtrate three be concentrated into 60 DEG C of relative densities be 1.18- 1.22, ethyl alcohol, which is added, makes volume fraction of ethanol reach 60%, stirs evenly, stands 24 hours at 0-4 DEG C, and filtration obtains filtrate four, Filtrate four is recycled into ethyl alcohol and is concentrated, adding water to 30 DEG C of relative densities is that 1.05-1.08 obtains mixed liquor two, after active carbon is added 40min is stirred at 60 DEG C, stirring is cooled to room temperature, and filtration obtains the as purslane extract of filter residue two after diatomite is added.
5. a kind for the treatment of spraying agent for ulcer of oral cavity of ingredient containing trollflower according to claim 4, it is characterised in that: the horse In the preparation step of sativa extract, the weight of active carbon is the 1% of two weight of mixed liquor, and the weight of diatomite is mixed liquor two The 3% of weight.
6. a kind for the treatment of spraying agent for ulcer of oral cavity of ingredient containing trollflower according to claim 1, it is characterised in that: described white Splendid achnatherum polysaccharide is made by following steps:
The bletilla striata is ground into middle powder one, it is secondary that middle powder one is added to the water constant temperature stirring and leaching at 70-80 DEG C, and one hour every time, Filtration obtains filtrate four, and it is 1.05-1.08 that filtrate four, which is concentrated into 60 DEG C of relative densities, and centrifugation obtains supernatant, by supernatant Continue to be concentrated into 60 DEG C of relative densities to be 1.18-1.22, ethyl alcohol, which is added, makes volume fraction of ethanol reach 70%, stirs evenly, 0-4 24 hours are stood at DEG C, it is bletilla polysaccharide that centrifugation, which obtains precipitating,.
7. a kind for the treatment of spraying agent for ulcer of oral cavity of ingredient containing trollflower according to claim 1, it is characterised in that: the table Face activating agent is Tween 80.
8. a kind for the treatment of spraying agent for ulcer of oral cavity of ingredient containing trollflower according to claim 1, it is characterised in that: the rose Common vetch berry extract is made by following steps:
Middle powder two is ground into after cynarrhodion is enucleated, it is 3 that middle powder two, which is added after water, and adjusts pH value, is heated after zytase is added To 55 DEG C, stirring boils enzyme deactivation in 5 minutes and obtains extracting solution after extracting 2.5 hours, will extract solution and is centrifuged to obtain supernatant, adds Entering ethyl alcohol makes volume fraction of ethanol reach 75%, is stored at room temperature filtration after precipitating 2 hours and obtains filter residue three, is by the drying of filter residue three Obtain rose hip extract.
9. a kind of preparation side of the treatment spraying agent for ulcer of oral cavity of ingredient containing trollflower according to any one of claims 1 to 8 Method, it is characterised in that: the following steps are included:
Borneol, menthol are ground to melting, the water grinding that the weight such as surfactant and surfactant are then added is equal It is even, it is mixed under stirring condition with trollflower, purslane extract, bletilla polysaccharide, rose hip extract, is stirring evenly and then adding into mountain Pears acid simultaneously adds water to 1000mL, continues after mixing evenly up to treatment spraying agent for ulcer of oral cavity.
CN201910720177.1A 2019-08-06 2019-08-06 A kind for the treatment of spraying agent for ulcer of oral cavity of the ingredient containing trollflower and preparation method thereof Pending CN110302263A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111467278A (en) * 2020-05-22 2020-07-31 奥乌力吉 Jinlian refreshing spray
CN114558072A (en) * 2022-03-02 2022-05-31 长江师范学院 Spray for treating pharyngitis and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110051605A (en) * 2019-05-25 2019-07-26 广东大鹏医药科技有限公司 A kind of oral cleaning anti-inflammation liquid of the ingredient containing trollflower and preparation method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110051605A (en) * 2019-05-25 2019-07-26 广东大鹏医药科技有限公司 A kind of oral cleaning anti-inflammation liquid of the ingredient containing trollflower and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111467278A (en) * 2020-05-22 2020-07-31 奥乌力吉 Jinlian refreshing spray
CN114558072A (en) * 2022-03-02 2022-05-31 长江师范学院 Spray for treating pharyngitis and preparation method thereof

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Application publication date: 20191008